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https://www.readbyqxmd.com/read/28088073/strategies-to-design-clinical-studies-to-identify-predictive-biomarkers-in-cancer-research
#1
REVIEW
Jose Luis Perez-Gracia, Miguel F Sanmamed, Ana Bosch, Ana Patiño-Garcia, Kurt A Schalper, Victor Segura, Joaquim Bellmunt, Josep Tabernero, Christopher J Sweeney, Toni K Choueiri, Miguel Martín, Juan Pablo Fusco, Maria Esperanza Rodriguez-Ruiz, Alfonso Calvo, Celia Prior, Luis Paz-Ares, Ruben Pio, Enrique Gonzalez-Billalabeitia, Alvaro Gonzalez Hernandez, David Páez, Jose María Piulats, Alfonso Gurpide, Mapi Andueza, Guillermo de Velasco, Roberto Pazo, Enrique Grande, Pilar Nicolas, Francisco Abad-Santos, Jesus Garcia-Donas, Daniel Castellano, María J Pajares, Cristina Suarez, Ramon Colomer, Luis M Montuenga, Ignacio Melero
The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs remains one of the key challenges in cancer research. Despite its relevance, no efficient study designs to identify promising candidate biomarkers have been established. This has led to the proliferation of a myriad of exploratory studies using dissimilar strategies, most of which fail to identify any promising targets and are seldom validated. The lack of a proper methodology also determines that many anti-cancer drugs are developed below their potential, due to failure to identify predictive biomarkers...
December 30, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28087016/familial-outbreak-of-eruptive-pseudoangiomatosis-with-dermoscopic-and-histopathologic-correlation
#2
Carlos Gustavo Wambier, Mark Aaron Cappel, Tayza Katelline Danilau Ostroski, Mário Rodrigues Montemor Netto, Sarah Perillo de Farias Wambier, Bruna Lais Santos de Jesus, Eurico Arruda
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28079959/removal-of-multiple-contaminants-from-water-by-polyoxometalate-supported-ionic-liquid-phases-pom-silps
#3
Sven Herrmann, Laura De Matteis, Jesús M de la Fuente, Scott G Mitchell, Carsten Streb
The simultaneous removal of organic, inorganic, and microbial contaminants from water by one material offers significant advantages when fast, facile, and robust water purification is required. Herein, we present a supported ionic liquid phase (SILP) composite where each component targets a specific type of water contaminant: a polyoxometalate-ionic liquid (POM-IL) is immobilized on porous silica, giving the heterogeneous SILP. The water-insoluble POM-IL is composed of antimicrobial alkylammonium cations and lacunary polyoxometalate anions with heavy-metal binding sites...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28078169/a-survey-of-energy-drink-consumption-patterns-among-college-students-at-a-mostly-hispanic-university
#4
Ernesto Cabezas-Bou, Jeidiel De León-Arbucias, Nikol Matos-Vergara, Yocasta Álvarez-Bagnarol, Jesús Ortega-Guzmán, Karla Narváez-Pérez, Nelson D Cruz-Bermúdez, Manuel Díaz-Ríos
Background: The purpose of this study was to determine energy drink (ED) consumption patterns among Hispanic college students. We measured the prevalence and frequency of ED consumption according to gender, degree programs, and specific university-related and social situations. In addition, we assessed the frequency of consumption of EDs mixed with alcoholic beverages. Methods: A total of 508 college students from the University of Puerto Rico, the largest Hispanic institution of higher education statewide, completed an online questionnaire...
December 1, 2016: Journal of Caffeine Research
https://www.readbyqxmd.com/read/28076554/-training-of-health-professionals-in-breastfeeding-and-its-association-with-knowledge-skills-and-practices
#5
Patricia Carvalho de Jesus, Maria Inês Couto de Oliveira, José Rodrigo de Moraes
A cross-sectional study was conducted in the 15 hospitals with over 1000 deliveries/year in Rio de Janeiro, Brazil, to verify the association between training of health professionals in breastfeeding and professional knowledge, skills and practices. Interviews were staged with 215 health professionals, 48.4% working in Baby-Friendly Hospitals, by means of a questionnaire adapted from the revalidation instrument of the initiative. The three dichotomized outcomes were subjected to bivariate and multivariate analysis...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076477/pediatric-liver-transplantation-with-ex-situ-liver-transection-and-the-application-of-the-human-fibrinogen-and-thrombin-sponge-in-the-wound-area
#6
Fernando Pompeu Piza Vicentine, Adriano Miziara Gonzalez, Ramiro Anthero de Azevedo, Barbara Burza Benini, Marcelo Moura Linhares, Gaspar de Jesus Lopes-Filho, Jose Luiz Martins, Alcides Augusto Salzedas-Netto
Background: Surgical strategy to increase the number of liver transplants in the pediatric population is the ex-situ liver transection (reduction or split). However, it is associated with complications such as hemorrhage and leaks. The human fibrinogen and thrombin sponge is useful for improving hemostasis in liver surgery. Aim: Compare pediatric liver transplants with ex-situ liver transection (reduction or split) with or without the human fibrinogen and thrombin sponge...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28076474/growth-factors-and-cox2-in-wound-healing-an-experimental-study-with-ehrlich-tumors
#7
Flávio L L Salgado, Ricardo Artigiani-Neto, Gaspar de Jesus Lopes-Filho
Background: Healing is an innate biological phenomenon, and carcinogenesis acquired, but with common humoral and cellular elements. Carcinogenesis interferes negatively in healing. Aim: To evaluate the histological changes in laparotomy scars of healthy Balb/c mice and with an Ehrlich tumor in its various forms of presentation. Methods: Fifty-four mice were divided into three groups of 18 animals. First group was the control; the second had Ehrlich tumor with ascites; and the third had the subcutaneous form of this tumor...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28073685/obesity-is-the-main-determinant-of-insulin-resistance-more-than-the-circulating-pro-inflammatory-cytokines-levels-in-rheumatoid-arthritis-patients
#8
Jesus Castillo-Hernandez, Martha Imelda Maldonado-Cervantes, Juan Pablo Reyes, Nuria Patiño-Marin, Enrique Maldonado-Cervantes, Claudia Solorzano-Rodriguez, Esperanza de la Cruz Mendoza, Brenda Alvarado-Sanchez
BACKGROUND: Systemic blockade of TNF-α in Rheumatoid arthritis (RA) with insulin resistance (IR) seems to produce more improvement in insulin sensitivity in normal weight patients with RA than in obese patients with RA, suggesting that systemic-inflammation and obesity are independent risk factors for IR in RA patients. OBJECTIVES: To evaluate the insulin resistance in: normal weight patients with RA (RA NW), overweight patients with RA (RA OW), obese RA patients (RA OB), and matched control subjects with normal weight (NW) and obesity (OB); and its association with major cytokines involved in the pathogenesis of the disease...
December 20, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28070765/health-impacts-of-religious-practices-and-beliefs-associated-with-the-church-of-jesus-christ-of-latter-day-saints
#9
Rocío de Diego Cordero, Bárbara Badanta Romero
The aim of the study is to discuss the relationship between lifestyle marked by The Church of Jesus Christ of Latter-day Saints and health. PubMed, CINAHL, PsycINFO, WOS y Scopus were the databases used for this literature review, with these descriptors: "Mormons", "mormons religion", "health". Inclusion criteria were articles with full text available, published between 2005 and 2016, in English or Spanish language. Results show that following the restrictive Mormon doctrine generates beneficial effects for the health...
January 9, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28067899/nitric-oxide-mediates-aortic-disease-in-mice-deficient-in-the-metalloprotease-adamts1-and-in-a-mouse-model-of-marfan-syndrome
#10
Jorge Oller, Nerea Méndez-Barbero, E Josue Ruiz, Silvia Villahoz, Marjolijn Renard, Lizet I Canelas, Ana M Briones, Rut Alberca, Noelia Lozano-Vidal, María A Hurlé, Dianna Milewicz, Arturo Evangelista, Mercedes Salaices, J Francisco Nistal, Luis Jesús Jiménez-Borreguero, Julie De Backer, Miguel R Campanero, Juan Miguel Redondo
Heritable thoracic aortic aneurysms and dissections (TAAD), including Marfan syndrome (MFS), currently lack a cure, and causative mutations have been identified for only a fraction of affected families. Here we identify the metalloproteinase ADAMTS1 and inducible nitric oxide synthase (NOS2) as therapeutic targets in individuals with TAAD. We show that Adamts1 is a major mediator of vascular homeostasis, given that genetic haploinsufficiency of Adamts1 in mice causes TAAD similar to MFS. Aortic nitric oxide and Nos2 levels were higher in Adamts1-deficient mice and in a mouse model of MFS (hereafter referred to as MFS mice), and Nos2 inactivation protected both types of mice from aortic pathology...
January 9, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28065377/prognostic-value-of-computed-tomography-pulmonary-angiography-indices-in-patients-with-cancer-related-pulmonary-embolism-data-from-a-multicenter-cohort-study
#11
Juana María Plasencia-Martínez, Alberto Carmona-Bayonas, David Calvo-Temprano, Paula Jiménez-Fonseca, Francisco Fenoy, Mariana Benegas, Marcelo Sánchez, Carme Font, Diego Varona, David Martínez de la Haza, Jesús Pueyo, Mercè Biosca, Maite Antonio, Carmen Beato, Pilar Solís, Laura Fáez, Irma de Al Haba, Susana Hernández-Muñiz, Olga Madridano, Mar Martín, Eduardo Castañón, Avinash Ramchandani, Pablo Marchena, Manuel Sánchez-Cánovas, María Ángeles Vicente, Mari José Martínez, Ángela Fernández-Plaza, Lourdes Martínez-Encarnación, Alejandro Puerta, Ángel Domínguez, Daniel Rodríguez, Gema Marín, Remedios Otero, Fernando Sánchez-Lasheras, Vicente Vicente
OBJECTIVE: To analyze the prognostic value of pulmonary artery obstruction versus right-ventricle (RV) dysfunction radiologic indices in cancer-related pulmonary embolism (PE). METHODS: We enrolled 303 consecutive patients with paraneoplastic PE, evaluated by computed tomography pulmonary angiography (CTPA) between 2013 and 2014. The primary outcome measure was serious complications at 15days. Multivariate analyses were conducted by using binary logistic and robust regressions...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28062685/development-and-validation-of-the-increment-esbl-predictive-score-for-mortality-in-patients-with-bloodstream-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae
#12
Zaira Raquel Palacios-Baena, Belén Gutiérrez-Gutiérrez, Marina De Cueto, Pierluigi Viale, Mario Venditti, Alicia Hernández-Torres, Antonio Oliver, Luis Martínez-Martínez, Esther Calbo, Vicente Pintado, Oriol Gasch, Benito Almirante, José Antonio Lepe, Johann Pitout, Murat Akova, Carmen Peña-Miralles, Mitchell J Schwaber, Mario Tumbarello, Evelina Tacconelli, Julia Origüen, Nuria Prim, German Bou, Helen Giamarellou, Joaquín Bermejo, Axel Hamprecht, Federico Pérez, Manuel Almela, Warren Lowman, Po-Ren Hsueh, Carolina Navarro-San Francisco, Julián Torre-Cisneros, Yehuda Carmeli, Robert A Bonomo, David L Paterson, Álvaro Pascual, Jesús Rodríguez-Baño
BACKGROUND: Bloodstream infections (BSIs) due to ESBL-producing Enterobacteriaceae (ESBL-E) are frequent yet outcome prediction rules for clinical use have not been developed. The objective was to define and validate a predictive risk score for 30 day mortality. METHODS: A multinational retrospective cohort study including consecutive episodes of BSI due to ESBL-E was performed; cases were randomly assigned to a derivation cohort (DC) or a validation cohort (VC)...
January 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28060766/opposing-roles-of-pik3ca-gene-alterations-to-ezh2-signaling-in-non-muscle-invasive-bladder-cancer
#13
Cristina Segovia, Mónica Martínez-Fernández, Marta Dueñas, Carolina Rubio, Fernando F López-Calderón, Clotilde Costa, Cristina Saiz-Ladera, María Fernández-Grajera, José Duarte, Huberto García Muñoz, Federico de la Rosa, Felipe Villacampa, Daniel Castellano, Jesús M Paramio
The high rates of tumor recurrence and progression represent a major clinical problem in non-muscle invasive bladder cancer. Previous data showed that EZH2-dependent signaling mediates these processes, whereas the frequent alterations of PIK3CA gene (copy gains and mutations) are predictive of reduced recurrence. Here we show, using clinical samples and bladder cancer cell lines, a functional interaction between EZH2- and PIK3CA-dependent signaling pathways. PIK3CA alterations mediated, on the one hand, the increased expression of two miRNAs, miR-101 and miR-138, which posttranscriptionally downregulate EZH2 expression...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28060266/in-vivo-study-of-human-endothelial-pericyte-interaction-using-the-matrix-gel-plug-assay-in-mouse
#14
Ke Yuan, Mark E Orcholski, Ngan F Huang, Vinicio A de Jesus Perez
Angiogenesis is the process by which new blood vessels are formed from existing vessels. New vessel growth requires coordinated endothelial cell proliferation, migration, and alignment to form tubular structures followed by recruitment of pericytes to provide mural support and facilitate vessel maturation. Current in vitro cell culture approaches cannot fully reproduce the complex biological environment where endothelial cells and pericytes interact to produce functional vessels. We present a novel application of the in vivo matrix gel plug assay to study endothelial-pericyte interactions and formation of functional blood vessels using severe combined immune deficiency mutation (SCID) mice...
December 19, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059677/hydrocephalus-in-a-patient-with-an-unruptured-pial-arteriovenous-fistula-hydrodynamic-considerations-endovascular-treatment-and-clinical-course
#15
Jesús A Morales-Gómez, Vicente V Garza-Oyervides, José A Arenas-Ruiz, Mariana Mercado-Flores, C Guillermo Elizondo-Riojas, Frederick A Boop, Ángel Martínez-Ponce de León
Intracranial pial arteriovenous fistulas, also known as nongalenic fistulas, are rare vascular malformations affecting predominantly the pediatric population. Hydrocephalus is an unusual presentation in which the exact pathophysiology is not fully understood. The aim of treatment in these cases is occlusion of the fistula prior to considering ventricular shunting. Here, the authors describe the hydrodynamic considerations of the paravascular pathway and the resolution of hydrocephalus with endovascular treatment of the fistula...
January 6, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28056025/development-of-diagnostics-for-chagas-disease-where-should-we-put-our-limited-resources
#16
Albert Picado, Andrea Angheben, Andrea Marchiol, Belkisyolé Alarcón de Noya, Laurence Flevaud, Maria Jesus Pinazo, Montserrat Gállego, Sheba Meymandi, Silvia Moriana
No abstract text is available yet for this article.
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28055999/-role-of-the-sympathetic-nervous-system-in-vasovagal-syncope-and-rationale-for-beta-blockers-and-norepinephrine-transporter-inhibitors
#17
Manlio F Márquez, Jorge Rafael Gómez-Flores, Jesús A González-Hermosillo, Teresita de Jesús Ruíz-Siller, Manuel Cárdenas
Vasovagal or neurocardiogenic syncope is a common clinical situation and, as with other entities associated with orthostatic intolerance, the underlying condition is a dysfunction of the autonomic nervous system. This article reviews various aspects of vasovagal syncope, including its relationship with orthostatic intolerance and the role of the autonomic nervous system in it. A brief history of the problem is given, as well as a description of how the names and associated concepts have evolved. The response of the sympathetic system to orthostatic stress, the physiology of the baroreflex system and the neurohumoral changes that occur with standing are analyzed...
December 29, 2016: Medwave
https://www.readbyqxmd.com/read/28053973/noninvasive-ventilation-during-the-weaning-process-in-chronically-critically-ill-patients
#18
Jesus Sancho, Emilio Servera, Luis Jara-Palomares, Emilia Barrot, Raquel Sanchez-Oro-Gómez, F Javier Gómez de Terreros, M Jesús Martín-Vicente, Isabel Utrabo, M Belen Núñez, Alicia Binimelis, Ernest Sala, Enrique Zamora, Gonzalo Segrelles, Angel Ortega-Gonzalez, Fernando Masa
Chronically critically ill patients often undergo prolonged mechanical ventilation. The role of noninvasive ventilation (NIV) during weaning of these patients remains unclear. The aim of this study was to determine the value of NIV and whether a parameter can predict the need for NIV in chronically critically ill patients during the weaning process. We conducted a prospective study that included chronically critically ill patients admitted to Spanish respiratory care units. The weaning method used consisted of progressive periods of spontaneous breathing trials...
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/28052954/clinical-features-and-short-term-outcomes-of-cancer-patients-with-suspected-and-unsuspected-pulmonary-embolism-the-epiphany-study
#19
Carme Font, Alberto Carmona-Bayonas, Carmen Beato, Òscar Reig, Antonia Sáez, Paula Jiménez-Fonseca, Juana M Plasencia, David Calvo-Temprano, Marcelo Sanchez, Mariana Benegas, Mercedes Biosca, Diego Varona, Maria Angeles Vicente, Laura Faez, Maria Del Pilar Solís, Irma de la Haba, Maite Antonio, Olga Madridano, Eduardo Castañon, María Jose Martinez, Pablo Marchena, Avinash Ramchandani, Angel Dominguez, Alejandro Puerta, David Martinez de la Haza, Jesus Pueyo, Susana Hernandez, Angela Fernandez-Plaza, Lourdes Martinez-Encarnacion, Mar Martin, Gema Marin, Francisco Ayala, Vicente Vicente, Remedios Otero
The study aimed to identify predictors of overall 30-day mortality in cancer patients with pulmonary embolism including suspected pulmonary embolism (SPE) and unsuspected pulmonary embolism (UPE) events. Secondary outcomes included 30- and 90-day major bleeding and venous thromboembolism (VTE) recurrence.The study cohort included 1033 consecutive patients with pulmonary embolism from the multicentre observational ambispective EPIPHANY study (March 2006-October 2014). A subgroup of 497 patients prospectively assessed for the study were subclassified into three work-up scenarios (SPE, truly asymptomatic UPE and UPE with symptoms) to assess outcomes...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28049064/nanoparticles-for-multi-modality-cancer-diagnosis-simple-protocol-for-self-assembly-of-gold-nanoclusters-mediated-by-gadolinium-ions
#20
Wenxiu Hou, Fangfang Xia, Gabriel Alfranca, Hao Yan, Xiao Zhi, Yanlei Liu, Chen Peng, Chunlei Zhang, Jesus Martinez de la Fuente, Daxiang Cui
It is essential to develop a simple synthetic strategy to improve the quality of multifunctional contrast agents for cancer diagnosis. Herein, we report a time-saving method for gadolinium (Gd(3+)) ions-mediated self-assembly of gold nanoclusters (GNCs) into monodisperse spherical nanoparticles (GNCNs) under mild conditions. The monodisperse, regular and colloidal stable GNCNs were formed via selectively inducing electrostatic interactions between negatively-charged carboxylic groups of gold nanoclusters and trivalent cations of gadolinium in aqueous solution...
December 27, 2016: Biomaterials
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