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https://www.readbyqxmd.com/read/29791660/potential-role-of-sorafenib-as-neoadjuvant-therapy-in-unresectable-papillary-thyroid-cancer
#1
Debora L S Danilovic, Gilberto Castro, Felipe S R Roitberg, Felipe A B Vanderlei, Fernanda A Bonani, Ricardo M C Freitas, George B Coura-Filho, Rosalinda Y Camargo, Marco A Kulcsar, Suemi Marui, Ana O Hoff
Total thyroidectomy, radioiodine (RAI) therapy, and TSH suppression are the mainstay treatment for differentiated thyroid carcinomas (DTCs). Treatments for metastatic disease include surgery, external-beam radiotherapy, RAI, and kinase inhibitors for progressive iodine-refractory disease. Unresectable locoregional disease remains a challenge, as standard therapy with RAI becomes unfeasible. We report a case of a young patient who presented with unresectable papillary thyroid carcinoma (PTC), and treatment with sorafenib allowed total thyroidectomy and RAI therapy...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791652/inflammatory-myopathy-in-the-context-of-an-unusual-overlapping-laminopathy
#2
Cristina Guillín-Amarelle, Sofía Sánchez-Iglesias, Antonio Mera, Elena Pintos, Ana Castro-Pais, Leticia Rodríguez-Cañete, Julio Pardo, Felipe F Casanueva, David Araújo-Vilar
Laminopathies are genetic disorders associated with alterations in nuclear envelope proteins, known as lamins. The LMNA gene encodes lamins A and C, and LMNA mutations have been linked to diseases involving fat (type 2 familial partial lipodystrophy [FPLD2]), muscle (type 2 Emery-Dreifuss muscular dystrophy [EDMD2], type 1B limb-girdle muscular dystrophy [LGMD1B], and dilated cardiomyopathy), nerves (type 2B1 Charcot-Marie-Tooth disease), and premature aging syndromes. Moreover, overlapping syndromes have been reported...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791620/intervention-time-until-discharge-for-newborns-on-transition-from-gavage-to-exclusive-oral-feeding
#3
Andréa Monteiro Correia Medeiros, Blenda Karen Batista Ramos, Déborah Letticia Santana Santos Bomfim, Conceição Lima Alvelos, Talita Cardoso da Silva, Ikaro Daniel de Carvalho Barreto, Felipe Batista Santos, Ricardo Queiroz Gurgel
Purpose Measure the intervention time required for transition from gavage to exclusive oral feeding, comparing newborns exposed exclusively to the mother's breast with those who, in addition to breastfeeding, received supplementation using a cup or baby bottle. Methods Analytical, longitudinal, cohort study conducted with 165 newborns (NB) divided into groups according to severity of medical complications (G1-with no complications; G2-with significant complications), and into subgroups according to feeding mechanism (A and B)...
2018: CoDAS
https://www.readbyqxmd.com/read/29791520/use-of-direct-oral-anticoagulants-for-chronic-thromboembolic-pulmonary-hypertension
#4
Francisca Alexandra Gavilanes-Oleas, Jose Leonidas Alves, Caio Julio Cesar Fernandes, Luis Felipe Lopes Prada, William Salibe Filho, Mario Terra Filho, Luciana Morinaga, Susana Hoette, Carlos Jardim, Rogerio Souza
OBJECTIVES: Chronic thromboembolic pulmonary hypertension is one of the most prevalent forms of pulmonary hypertension and is a major complication of acute pulmonary embolism. One mainstay of chronic thromboembolic pulmonary hypertension treatment is lifelong anticoagulation. The recent advent of direct oral anticoagulants for acute pulmonary embolism treatment has provided a viable and effective alternative for treating this condition. However, little is known about the efficacy of this new class of drugs for treating chronic thromboembolic pulmonary hypertension...
May 17, 2018: Clinics
https://www.readbyqxmd.com/read/29791398/ultralow-chirp-photonic-crystal-fiber-mach-zehnder-interferometer
#5
William O F Carvalho, Danilo H Spadoti, Enrique Silvestre, Felipe Beltran-Mejia
A photonic crystal fiber Mach-Zehnder interferometer design was optimized to obtain high performance and ultralow chirp. Two long-period gratings were used to excite the cladding modes, and the rich structure of the cladding was tailored to obtain a slightly chirped free spectral range, as required by the Telecommunication Standardization Sector of the International Telecommunication Union (ITU-T) Norm G.694.1. Finally, a fabrication tolerance analysis was performed. The advantages of the proposed device are an ultralow chirp, high bandwidth, and fabrication robustness tolerance...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29789978/diauxic-growth-of-clostridium-acetobutylicum-atcc-824-when-grown-on-mixtures-of-glucose-and-cellobiose
#6
Felipe Buendia-Kandia, Emmanuel Rondags, Xavier Framboisier, Guillain Mauviel, Anthony Dufour, Emmanuel Guedon
Clostridium acetobutylicum, a promising organism for biomass transformation, has the capacity to utilize a wide variety of carbon sources. During pre-treatments of (ligno) cellulose through thermic and/or enzymatic processes, complex mixtures of oligo saccharides with beta 1,4-glycosidic bonds can be produced. In this paper, the capability of C. acetobutylicum to ferment glucose and cellobiose, alone and in mixtures was studied. Kinetic studies indicated that a diauxic growth occurs when both glucose and cellobiose are present in the medium...
May 22, 2018: AMB Express
https://www.readbyqxmd.com/read/29789711/physical-activity-but-not-sedentary-time-is-associated-with-vitamin-d-status-in-adolescents-study-of-cardiovascular-risk-in-adolescents-erica
#7
Ana Carla Moreira da Silva, Felipe Vogt Cureau, Cecília Lacroix de Oliveira, Denise Tavares Giannini, Katia Vergetti Bloch, Maria Cristina Caetano Kuschnir, Eliane Said Dutra, Beatriz D Schaan, Kênia Mara Baiocchi de Carvalho
BACKGROUND/OBJECTIVES: The association between active lifestyle components and vitamin D status in adolescents remains relatively unexplored. We aimed to investigate independent and joint associations of moderate-to-vigorous physical activity (MVPA) and screen time with serum 25-hydroxyvitamin D [25(OH)D] concentrations in adolescents. METHODS: This multicenter cross-sectional study involved 1152 Brazilian adolescents (age 12-17 years). Serum 25(OH)D was measured in a single laboratory and categorized as ≤20, 21-29, or ≥30 ng/mL...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29789644/heritability-of-climate-relevant-traits-in-a-rainforest-skink
#8
Felipe Martins, Loeske Kruuk, John Llewelyn, Craig Moritz, Ben Phillips
There is justified concern about the impact of global warming on the persistence of tropical ectotherms. There is also growing evidence for strong selection on climate-relevant physiological traits. Understanding the evolutionary potential of populations is especially important for low dispersal organisms in isolated populations, because these populations have little choice but to adapt. Despite this, direct estimates of heritability and genetic correlations for physiological traits in ectotherms-which will determine their evolutionary responses to selection-are sparse, especially for reptiles...
May 22, 2018: Heredity
https://www.readbyqxmd.com/read/29789413/best-protocol-for-the-sit-to-stand-test-in-subjects-with-copd
#9
Andrea A Morita, Gianna W Bisca, Felipe V C Machado, Nidia A Hernandes, Fabio Pitta, Vanessa S Probst
BACKGROUND: Different protocols for the sit-to-stand test (STS) are available for assessing functional capacity in COPD. We sought to correlate each protocol of the STS (ie, the 5-repetition [5-rep STS], the 30-s STS, and the 1-min STS) with clinical outcomes in subjects with COPD. We also aimed to compare the 3 protocols of the STS, to verify their association and agreement, and to verify whether the 3 protocols are able to predict functional exercise capacity and physical activity in daily life (PADL)...
May 22, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29789162/fatigue-failure-load-of-an-adhesively-cemented-lithium-disilicate-glass-ceramic-conventional-ceramic-etching-vs-etch-prime-one-step-primer
#10
Maitê Munhoz Scherer, Catina Prochnow, Andressa Borin Venturini, Gabriel Kalil Rocha Pereira, Thiago Augusto de Lima Burgo, Marília Pivetta Rippe, Luiz Felipe Valandro
OBJECTIVES: To evaluate the effect of different glass-ceramic surface treatments and aging on the fatigue failure load of a lithium disilicate glass-ceramic adhesively cemented to a dentin analogue material. METHODS: One hundred and twenty (120) disc-shaped lithium disilicate specimens (Ø=10mm, thickness=1.5mm) were produced and randomly allocated (n=20) into 6 groups, considering 2 study factors: "surface treatment" in 3 levels (SIL-silane application only; HF5+SIL-5% hydrofluoric acid etching and silane application; ME&P-etching with an one-step ceramic primer), and "storage" in 2 levels (baseline-storage for 7 days; aging-storage for 90 days+12,000 thermal cycles)...
May 19, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29788140/immune-unreactive-urinary-albumin-as-a-predictor-of-cardiovascular-events-the-hortega-study
#11
Fernando Martínez, Gernot Pichler, Adrian Ruiz, Juan C Martín-Escudero, Felipe J Chaves, Veronica Gonzalez-Albert, Maria Tellez-Plaza, Hiddo J L Heerspink, Dick D E Zeeuw, Josep Redon
Background: We aimed to determine if immune-unreactive albumin excretion (IURAE) is associated with cardiovascular (CV) events in a representative sample of a general population from Spain. Methods: We included 1297 subjects (mean age ± standard error 48.0 ± 0.2 years, 48% females), who participated in the Hortega Follow-Up Study. The primary endpoint was incidence of fatal and non-fatal CV events. Urinary albumin excretion (UAE) was measured in spot voided urine, frozen at -80°C, by immunonephelometry [immune-reactive albumin excretion (IRAE)] and by high-performance liquid chromatography (HPLC) [total albumin excretion (AE)]...
May 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29788115/neuropathology-education-using-social-media
#12
James S Nix, Jerad M Gardner, Felipe Costa, Alexandre L Soares, Fausto J Rodriguez, Brian Moore, Maria Martinez-Lage, Sunita Ahlawat, Murat Gokden, Douglas C Anthony
Social media use continues to grow among pathologists. Discussions of current topics, posts of educational information, and images of pathological entities are commonly found and distributed on popular sites such as Facebook and Twitter. However, little is known about the presence of neuropathology content in social media and the audience for such content. We designed and distributed a survey to assess the demographics of users viewing neuropathology content and their opinions about neuropathology in social media...
June 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29788088/report-nia-workshop-on-measures-of-physiologic-resiliencies-in-human-aging
#13
Evan C Hadley, George A Kuchel, Anne B Newman, Heather G Allore, Jenna M Bartley, Cindy S Bergeman, Michael L Blinov, Cathleen S Colon-Emeric, Firdaus S Dabhar, Laura L Dugan, Chhanda Dutta, Basil A Eldadah, Luigi Ferrucci, James L Kirkland, Stephen B Kritchevsky, Lewis A Lipsitz, Neelesh K Nadkarni, May J Reed, Kenneth E Schmader, Felipe Sierra, Stephanie A Studenski, Ravi Varadhan, Jeremy D Walston, Heather E Whitson, Raymond Yung
No abstract text is available yet for this article.
May 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29785709/four-year-follow-up-of-a-single-arm-phase-ii-clinical-trial-of-ibrutinib-with-rituximab-ir-in-patients-with-relapsed-refractory-mantle-cell-lymphoma-mcl
#14
Preetesh Jain, Jorge Romaguera, Samer A Srour, Hun J Lee, Frederick Hagemeister, Jason Westin, Luis Fayad, Felipe Samaniego, Maria Badillo, Liang Zhang, Lorreta Nastoupil, Rashmi Kanagal-Shamanna, Nathan Fowler, Michael L Wang
Ibrutinib has shown significant activity in patients with relapsed or refractory mantle cell lymphoma (RR-MCL). We report the long-term outcome and safety profile of a single-centre, single arm, open-label, phase 2 study of RR-MCL treated with IR. Overall, the median follow-up time was 47 months (range 1-52 months), median duration on treatment was 16 months (range 1-53 months) and median number of treatment cycles was 17 (range 1-56). Twenty-nine patients (58%) achieved complete remission and of these, 12 patients continue on study...
May 22, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29785565/supplementation-strategies-for-nellore-female-calves-in-creep-feeding-to-improve-the-performance-nutritional-and-metabolic-responses
#15
Daniel Mageste de Almeida, Marcos Inácio Marcondes, Luciana Navajas Rennó, Leandro Soares Martins, David Esteban Contreras Marquez, Faider Castaño Villadiego, Felipe Velez Saldarriaga, Román Maza Ortega, Deilen Paff Sotelo Moreno, Sidnei Antônio Lopes, Manuela Acevedo Cardozo, Mário Fonseca Paulino
The objective of this study was to evaluate the effects of supplementation strategy on performance, nutritional and metabolic characteristics of Nellore suckling female calves, on grazing Urochloa decumbens during the rainy-dry transition period. Forty-four Nellore female calves, averaging 147.6 ± 1.34 kg (4 months), were used. A single supplement 20% of crude protein of dry matter was provided, consisting of daily supplement at 0.0, 0.2, 0.4, or 0.6% of body weight. A positive linear effect (P < 0...
May 21, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29785242/role-of-oxidative-stress-as-key-regulator-of-muscle-wasting-during-cachexia
#16
REVIEW
Johanna Ábrigo, Alvaro A Elorza, Claudia A Riedel, Cristian Vilos, Felipe Simon, Daniel Cabrera, Lisbell Estrada, Claudio Cabello-Verrugio
Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of muscular mass and the contractile capacity of the skeletal muscle as a consequence of muscular weakness and decreased force generation. Cachexia is defined as a pathological condition secondary to illness characterized by the progressive loss of muscle mass with or without loss of fat mass and with concomitant diminution of muscle strength. The molecular mechanisms involved in cachexia include oxidative stress, protein synthesis/degradation imbalance, autophagy deregulation, increased myonuclear apoptosis, and mitochondrial dysfunction...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29785028/the-reference-epigenome-and-regulatory-chromatin-landscape-of-chronic-lymphocytic-leukemia
#17
Renée Beekman, Vicente Chapaprieta, Núria Russiñol, Roser Vilarrasa-Blasi, Núria Verdaguer-Dot, Joost H A Martens, Martí Duran-Ferrer, Marta Kulis, François Serra, Biola M Javierre, Steven W Wingett, Guillem Clot, Ana C Queirós, Giancarlo Castellano, Julie Blanc, Marta Gut, Angelika Merkel, Simon Heath, Anna Vlasova, Sebastian Ullrich, Emilio Palumbo, Anna Enjuanes, David Martín-García, Sílvia Beà, Magda Pinyol, Marta Aymerich, Romina Royo, Montserrat Puiggros, David Torrents, Avik Datta, Ernesto Lowy, Myrto Kostadima, Maša Roller, Laura Clarke, Paul Flicek, Xabier Agirre, Felipe Prosper, Tycho Baumann, Julio Delgado, Armando López-Guillermo, Peter Fraser, Marie-Laure Yaspo, Roderic Guigó, Reiner Siebert, Marc A Martí-Renom, Xose S Puente, Carlos López-Otín, Ivo Gut, Hendrik G Stunnenberg, Elias Campo, Jose I Martin-Subero
Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which underlying epigenetic alterations are only partially understood. Here, we analyze the reference epigenome of seven primary CLLs and the regulatory chromatin landscape of 107 primary cases in the context of normal B cell differentiation. We identify that the CLL chromatin landscape is largely influenced by distinct dynamics during normal B cell maturation. Beyond this, we define extensive catalogues of regulatory elements de novo reprogrammed in CLL as a whole and in its major clinico-biological subtypes classified by IGHV somatic hypermutation levels...
May 21, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29783893/the-effects-of-transcranial-direct-current-stimulation-tdcs-combined-with-group-exercise-treatment-in-subjects-with-chronic-low-back-pain-a-pilot-randomized-control-trial
#18
Sofia Straudi, Sergio Buja, Andrea Baroni, Claudia Pavarelli, Giulia Pranovi, Felipe Fregni, Nino Basaglia
OBJECTIVE: To test the efficacy of transcranial direct current stimulation (tDCS) in addition to group exercise on non-specific chronic low back pain. DESIGN: Double-blinded randomized control trial. SUBJECTS: Patients with non-specific chronic low back pain. METHODS: A total of 35 subjects were recruited and allocated to real- or sham-tDCS followed by a group exercise protocol. Each patient underwent five sessions of brain stimulation followed by 10 sessions of group exercise...
May 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29783629/encapsulation-of-gold-nanostructures-and-oil-in-water-nanocarriers-in-microgels-with-biomedical-potential
#19
Mariela Inostroza-Riquelme, Andrea Vivanco, Pablo Lara, Simón Guerrero, Edison Salas-Huenuleo, Alejandro Chamorro, Lisette Leyton, Karen Bolaños, Eyleen Araya, Andrew F G Quest, Marcelo J Kogan, Felipe Oyarzun-Ampuero
Here we report the incorporation of gold nanostructures (nanospheres or nanorods, functionalized with carboxylate-end PEG) and curcumin oil-in-water (O/W) nanoemulsions (CurNem) into alginate microgels using the dripping technique. While gold nanostructures are promising nanomaterials for photothermal therapy applications, CurNem possess important pharmacological activities as reported here. In this sense, we evaluated the effect of CurNem on cell viability of both cancerous and non-cancerous cell lines (AGS and HEK293T, respectively), demonstrating preferential toxicity in cancer cells and safety for the non-cancerous cells...
May 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29783176/%C3%AF-3-and-folic-acid-act-against-depressive-like-behavior-and-oxidative-damage-in-the-brain-of-rats-subjected-to-early-or-late-life-stress
#20
Gislaine Z Réus, Amanda L Maciel, Helena M Abelaira, Airam B de Moura, Thays G de Souza, Thais R Dos Santos, Ana Caroline Darabas, Murilo Parzianello, Danyela Matos, Mariane Abatti, Ana Carolina Vieira, Vanessa Fucillini, Monique Michels, Felipe Dal-Pizzol, João Quevedo
OBJECTIVES: To investigate the antidepressant and antioxidant effects of omega-3, folic acid and n-acetylcysteine (NAC) in rats which were subjected to early or late life stress. METHODS: Early stress was induced through maternal deprivation (MD), while late life stress was induced using the chronic mild stress (CMS) protocol. Young rats which were subjected to MD and the adult rats which were subjected to CMS were treated with omega-3 fatty acids (0.72 g/kg), NAC (20 mg/kg) or folic acid (50 mg/kg) once/day, for a period of 20 days...
March 30, 2018: Nutrition
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