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Paula Ribeiro Mesquita, Silvia Gonçalves Ricci Neri, Ricardo M Lima, Felipe P Carpes, Ana Cristina de David
BACKGROUND: Obesity is associated with higher foot loading during walking. The impact of this condition on running, however, has yet to be elucidated. RESEARCH QUESTION: The purpose of this study was to examine the association between childhood obesity and plantar pressure distribution during running. METHODS: Forty-two volunteers aged 5-10 years took part in this cross-sectional study. Body mass index (BMI) was assessed for obesity classification...
March 14, 2018: Gait & Posture
Igor Braga Ribeiro, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Elinton Adami Chaim, Everton Cazzo
BACKGROUND: Although the incidence of leaks after Roux-en-Y gastric bypass (RYGB) significantly decreased over time, their detection still remains challenging. OBJECTIVE: This study aimed to determine the usefulness of drain amylase levels to detect leaks after RYGB. METHODS: This is a population-based study which enrolled 170 individuals who underwent RYGB. Drain amylase levels were determined on the first and fourth postoperative days. Two thresholds were evaluated: three times higher than the serum levels (parameter I) and higher than 250 IU/L (parameter II)...
January 2018: Arquivos de Gastroenterologia
Marcelo A Queiroz, Felipe de Galiza Barbosa, Carlos Alberto Buchpiguel, Giovanni Guido Cerri
The new technology of PET/MRI is a prototype of hybrid imaging, allowing for the combination of molecular data from PET scanning and morphofunctional information derived from MRI scanning. Recent advances regarding the technical aspects of this device, especially after the development of MRI-compatible silicon photomultipliers of PET, permitted an increase in the diagnostic performance of PET/MRI translated into dose reduction and higher imaging quality. Among several clinical applications, PET/MRI gains ground initially in oncology, where MRI per se plays an essential role in the assessment of primary tumors (which is limited in the case of PET/CT), including prostate, rectal and gynecological tumors...
January 2018: Revista da Associação Médica Brasileira
Andoni Garitano-Trojaola, Edurne San José-Enériz, Teresa Ezponda, Juan Pablo Unfried, Arantxa Carrasco-León, Nerea Razquin, Marina Barriocanal, Amaia Vilas-Zornoza, Bruno Sangro, Victor Segura, Felipe Prósper, Puri Fortes, Xabier Agirre
Long Non-Coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides in length. Several lncRNAs are involved in cell proliferation and are deregulated in several human tumors. Few lncRNAs have been described to play a role in Acute Lymphoblastic Leukemia (ALL). In this study, we carried out a genome wide lncRNA expression profiling in ALL samples and peripheral blood samples obtained from healthy donors. We detected 43 lncRNAs that were aberrantly expressed in ALL. Interestingly, among them, linc-PINT showed a significant downregulation in T and B-ALL...
February 27, 2018: Oncotarget
Casey A Grover, Jameel Sughair, Sydney Stoopes, Felipe Guillen, Leah Tellez, Tierra M Wilson, Charles Gaccione, Reb J H Close
Introduction: Case management is an effective, short-term means to reduce emergency department (ED) visits in frequent users of the ED. This study sought to determine the effectiveness of case management on frequent ED users, in terms of reducing ED and hospital length of stay (LOS), accrued costs, and utilization of diagnostic tests. Methods: The study consisted of a retrospective chart review of ED and inpatient visits in our hospital's ED case management program, comparing patient visits made in the one year prior to enrollment in the program, to the visits made in the one year after enrollment in the program...
March 2018: Western Journal of Emergency Medicine
Zhichao Wu, Felipe A Medeiros
Visual field testing is an important endpoint in glaucoma clinical trials, and the testing paradigm used can have a significant impact on the sample size requirements. To investigate this, this study included 353 eyes of 247 glaucoma patients seen over a 3-year period to extract real-world visual field rates of change and variability estimates to provide sample size estimates from computer simulations. The clinical trial scenario assumed that a new treatment was added to one of two groups that were both under routine clinical care, with various treatment effects examined...
March 20, 2018: Scientific Reports
Alberto Vergara-Fernández, Sergio Revah, Patricio Moreno-Casas, Felipe Scott
Volatile organic compounds (VOCs) are ubiquitous contaminants that can be found both in outdoor and indoor air, posing risks to human health and the ecosystems. The treatment of air contaminated with VOCs in low concentrations can be effectively performed using biofiltration, especially when VOCs are hydrophilic. However, the performance of biofilters inoculated with bacteria has been found to be low with sparsely water soluble molecules when compared to biofilters where fungi develop. Using conceptual and mathematical models, this review presents an overview of the physical, chemical and biological mechanisms that explain the differences in the performance of fungal and bacterial biofilters...
March 17, 2018: Biotechnology Advances
Marco Aurélio Petroni Montezuma, Felipe Paiva Fonseca, Bernar Monteiro Benites, Ciro Dantas Soares, Gleyson Kleber do Amaral-Silva, Oslei Paes de Almeida, Fernando Augusto Soares, Rosana Lima Pagano, Eduardo Rodrigues Fregnani
Ameloblastoma is a locally aggressive neoplasm with a poorly understood pathogenesis. Therefore, the aim of this study is to investigate whether COX-2 expression is associated with ameloblastoma microvascular density (MVD) and with tumor aggressiveness. Sixty-three cases of primary ameloblastomas arranged in tissue microarray were submitted to immunohistochemistry against cyclooxigenase-2 (COX-2) and CD34. Clinicopathological parameters regarding sex, age, tumour size, tumour duration, tumour location, treatment, recurrences, radiographic features, vestibular/lingual and basal cortical disruption and follow-up data were obtained from patients' medical records and correlated with the proteins expression...
March 15, 2018: Pathology, Research and Practice
Garcia-Chagollan Mariel, Carranza-Torres Irma Edith, Carranza-Rosales Pilar, Guzmán-Delgado Nancy Elena, Ramírez-Montoya Humberto, Martínez-Silva María Guadalupe, Mariscal-Ramirez Ignacio, Barrón-Gallardo Carlos Alfredo, Pereira-Suárez Ana Laura, Aguilar-Lemarroy Adriana, Jave-Suárez Luis Felipe
BACKGROUND: Currently, one of the most used strategies for the treatment of newly diagnosed patients with breast cancer is neoadjuvant chemotherapy based on the application of taxanes and anthracyclines. However, despite the high number of patients who develop a complete pathological clinical response, resistance and relapse following this therapy continue to be a clinical challenge. As a component of the innate immune system, the cytotoxic function of Natural Killer (NK) cells plays an important role in the elimination of tumor cells...
January 1, 2018: Technology in Cancer Research & Treatment
Akim Felipe Santos Nobre, Danilo de Souza Almeida, Louise Canto Ferreira, Deimy Lima Ferreira, Edivaldo Costa Sousa Júnior, Maria de Nazaré do Socorro de Almeida Viana, Ingrid Christiane Silva, Bruna Teles Pinheiro, Stephen Francis Ferrari, Alexandre da Costa Linhares, Edna Aoba Ishikawa, Rita Catarina Medeiros Sousa, Maísa Silva de Sousa
The Human T-cell Lymphotropic Virus (HTLV-1) is a Deltaretrovírus that was first isolated in the 1970s, and associated with Adult T-cell Leucemia-Lymphoma (ATLL), and subsequently to Tropical Spastic Paraparesis-Myelopathy (TSP/HAM). The genetic diversity of the virus varies among geographic regions, although its mutation rate is very low (approximately 1% per thousand years) in comparison with other viruses. The present study determined the genetic diversity of HTLV-1 in the metropolitan region of Belém, in northern Brazil...
2018: PloS One
Mary Freire de Carvalho, Marco A N Vigilato, Julio A Pompei, Felipe Rocha, Alexandra Vokaty, Baldomero Molina Flores, Ottorino Cosivi, Victor J Del Rio Vilas
Through national efforts and regional cooperation under the umbrella of the Regional Program for the Elimination of Rabies, dog and human rabies have decreased significantly in Latin America and Caribbean (LAC) countries over the last three decades. To achieve this decline, LAC countries had to develop national plans, and consolidate capabilities such as regular mass dog vaccination, opportune post-exposure prophylaxis and sensitive surveillance. This paper presents longitudinal data for 21 LAC countries on dog vaccination, PEP and rabies surveillance collected from the biannual regional meeting for rabies directors from 1998-2014 and from the Regional Epidemiologic Surveillance System for Rabies (SIRVERA)...
March 20, 2018: PLoS Neglected Tropical Diseases
Karina Franco-Paredes, Felipe J Díaz-Reséndiz, Carlos Alejandro Hidalgo-Rasmussen, Lilián Elizabeth Bosques-Brugada
The purpose of the present study was to develop and evaluate a causal model of health-related quality of life (HRQoL) in adolescents with different body composition. The participants were 209 adolescents (107 women and 102 men) ranging from 10 to 15 years of age. A model based on that proposed by Wilson and Cleary (JAMA 273(1):59-65, 1995) was elaborated. The body composition of the participants was analyzed. They were asked to complete a battery of questionnaires composed of the following factors: biological status (BS; included body mass index and weight), symptomatic psychological status (SPS; included the variables of drive for thinness and food concerns), functional status (FS; composed of physical activity, food consumption estimation, and socioeconomic status), and HRQoL, which included the dimensions of psychological well-being, autonomy and relationship with parents, social support and peers, and the academic environment...
March 20, 2018: Eating and Weight Disorders: EWD
Letícia Kraft, Victoria Stadler Tasca Ribeiro, Luciana Cristina Wollmann, Paula Hansen Suss, Felipe Francisco Tuon
All cardiac allograft tissues are under potential contamination, requiring a validated terminal sterilization process or a minimal bioburden. The bioburden calculation is important to determine the bacterial burden and further decontamination and disinfection strategies for the valve processing. The aim of this study was to determine the bioburden from transport solution (TS) of heart valves obtained from non-heart-beating and heart-beating donors in different culture methods. The bioburden from TS was determined in 20 hearts donated for valve allograft tissue using membrane filter (MF) and direct inoculation...
March 19, 2018: Cell and Tissue Banking
Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Adalgisa Felippe Wiecikowski, Renato Sampaio Carvalho, Juliana de Lima Castro, Felipe Alves Gomes de Oliveira, Henrique Marcelo Gualberto Pereira, Venicio Feo da Veiga, Marcia Marques Alves Capella, Leandro Rocha, Carla Holandino
Cancer is one of the biggest problems in public health worldwide. Plants have been shown important role in anticancer research. Viscum album L. (Santalaceae), commonly known as mistletoe, is a semi-parasitic plant that grows on different host trees. In complementary medicine, extracts from European mistletoe ( Viscum album L.) have been used in the treatment of cancer. The study was conducted to identify chemical composition and antitumor potential of Viscum album tinctures. Chemical analysis performed by high resolution chromatography equipped with high resolution mass spectrometer identified caffeic acid, chlorogenic acid, sakuranetin, isosakuranetin, syringenin 4-O-glucoside, syringenin 4-O-apiosyl-glucoside, alangilignoside C and ligalbumoside A compounds...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Ubirajara Oliveira, Britaldo Silveira Soares-Filho, Adriano Pereira Paglia, Antonio D Brescovit, Claudio J B de Carvalho, Daniel Paiva Silva, Daniella T Rezende, Felipe Sá Fortes Leite, João Aguiar Nogueira Batista, João Paulo Peixoto Pena Barbosa, João Renato Stehmann, John S Ascher, Marcelo Ferreira de Vasconcelos, Paulo De Marco, Peter Löwenberg-Neto, Viviane Gianluppi Ferro, Adalberto J Santos
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
March 19, 2018: Scientific Reports
Felipe C Albuquerque, Adam S Arthur
No abstract text is available yet for this article.
April 2018: Journal of Neurointerventional Surgery
Thais Mauad, Felipe B P do Nascimento, Marisa Dolhnikoff, Milena C M Picka, Paulo H N Saldiva
BACKGROUND: Mortality related to asthma has decreased worldwide since the introduction of inhaled corticosteroid therapy in the past decades. However, there are still some asthma fatalities identified mainly in populations with less access to regular treatment. Pulmonary interstitial emphysema due to alveolar rupture has been rarely described as a complication of an acute severe asthma attack, and its identification in pathological analysis can be difficult. Previous studies reported the association of pulmonary interstitial emphysema and bronchial ductal gland ectasia in asthma...
March 20, 2018: BMC Pulmonary Medicine
Carla F S Guazelli, Larissa Staurengo-Ferrari, Ana C Zarpelon, Felipe A Pinho-Ribeiro, Kenji W Ruiz-Miyazawa, Fabiana T M C Vicentini, Josiane A Vignoli, Doumit Camilios-Neto, Sandra R Georgetti, Marcela M Baracat, Rubia Casagrande, Waldiceu A Verri
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular lesions, recruitment of inflammatory cells and increased levels of pro-inflammatory cytokine. The intra-articular administration of zymosan is an experimental model that promotes inflammatory parameters resembling RA. Therefore, this model was used to investigate the efficacy of quercetin as a treatment of articular inflammation. Treatment with quercetin dose-dependently reduced zymosan-induced hyperalgesia, articular edema and the recruitment of neutrophils to the knee joint cavity...
March 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Felipe F Conti, Fabiana Q Silva, Sunil K Srivastava, Justis P Ehlers, Andrew P Schachat, Rishi P Singh
BACKGROUND AND OBJECTIVE: In the ASSESS study, patients with neovascular age-related macular degeneration transitioned from other anti-vascular endothelial growth factor therapies to intravitreous aflibercept (Eylea; Regeneron, Tarrytown, NY) injections (IAI). The purpose was to determine the 36-month outcomes following the change from a fixed 24-month IAI dosing regimen to a routine clinical practice regimen. PATIENTS AND METHODS: Patients were treated with a fixed bimonthly regimen for the first 2 years...
March 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Luis Felipe C S Carvalho, Marcelo Saito Nogueira, Lázaro P M Neto, Tanmoy T Bhattacharjee, Airton A Martin
[This corrects the article on p. 5218 in vol. 8, PMID: 29188115.].
February 1, 2018: Biomedical Optics Express
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