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https://www.readbyqxmd.com/read/28806749/defining-the-genetic-susceptibility-to-cervical-neoplasia-a-genome-wide-association-study
#1
Paul J Leo, Margaret M Madeleine, Sophia Wang, Stephen M Schwartz, Felicity Newell, Ulrika Kymmer, Kari Hemminki, Goran Hallmans, Sven Tiews, Winfried Steinberg, Janet S Rader, Felipe Castro, Mahboobeh Safaeian, Eduardo L Franco, François Coutlée, Claes Ohlsson, Adrian Cortes, Mhairi Marshall, Pamela Mukhopadhyay, Katie Cremin, Lisa G Johnson, Suzanne Garland, Sepehr N Tabrizi, Nicolas Wentzensen, Freddy Sitas, Julian Little, Maggie Cruickshank, Ian H Frazer, Allan Hildesheim, Matthew A Brown
A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protective HLA haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of HLA-DRB1 and position 156 in HLA-B...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28806710/foot-strike-pattern-in-children-during-shod-unshod-running
#2
Pedro Ángel Latorre Román, Fernando Redondo Balboa, Felipe García Pinillos
The purpose of this study was to determine the foot strike patterns (FSPs) and neutral support (no INV/EVE and no foot rotation) in children, as well as to determine the influence of shod/unshod conditions and sex. A total of 713 children, aged 6 to 16 years, participated in this study (Age=10.28±2.71years, body mass index [BMI]=19.70±3.91kg/m(2), 302 girls and 411 boys). A sagittal and frontal-plane video (240Hz) was recorded using a high-speed camcorder, to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/eversion (INV/EVE) and foot rotation on initial contact...
August 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28805447/performance-on-naturalistic-virtual-reality-tasks-depends-on-global-cognitive-functioning-as-assessed-via-traditional-neurocognitive-tests
#3
Jorge Oliveira, Pedro Gamito, Daniyal M Alghazzawi, Habib M Fardoun, Pedro J Rosa, Tatiana Sousa, Luís Felipe Picareli, Diogo Morais, Paulo Lopes
This investigation sought to understand whether performance in naturalistic virtual reality tasks for cognitive assessment relates to the cognitive domains that are supposed to be measured. The Shoe Closet Test (SCT) was developed based on a simple visual search task involving attention skills, in which participants have to match each pair of shoes with the colors of the compartments in a virtual shoe closet. The interaction within the virtual environment was made using the Microsoft Kinect. The measures consisted of concurrent paper-and-pencil neurocognitive tests for global cognitive functioning, executive functions, attention, psychomotor ability, and the outcomes of the SCT...
August 14, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28805366/simultaneous-top-and-bottom-perovskite-interface-engineering-by-fullerene-surface-modification-of-titanium-dioxide-as-electron-transport-layer
#4
John Ciro, Santiago Mesa, Juan Felipe Montoya, Jose Ignacio Uribe, Rafael Betancur, Franklin Jaramillo
Optimization of the interface between the electron transport layer (ETL) and hybrid perovskite is crucial to achieve high performance perovskite solar cell (PSC) devices. Fullerene-based compounds have attracted attention as modifiers on the surface properties of TiO2, the archetypal ETL in regular n-i-p PSCs. However, the partial solubility of fullerenes in the aprotic solvents used for perovskite deposition hinders its application to low-temperature solution-processed PSCs. In this work, we introduce a new method for fullerene modification of TiO2 layers derived from nanoparticles (NPs) inks...
August 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28805204/corrigendum-stereocilia-staircase-spacing-is-influenced-by-myosin-iii-motors-and-their-cargos-espin-1-and-espin-like
#5
Seham Ebrahim, Matthew R Avenarius, M'hamed Grati, Jocelyn F Krey, Alanna M Windsor, Aurea D Sousa, Angela Ballesteros, Runjia Cui, Bryan A Millis, Felipe T Salles, Michelle A Baird, Michael W Davidson, Sherri M Jones, Dongseok Choi, Lijin Dong, Manmeet H Raval, Christopher M Yengo, Peter G Barr-Gillespie, Bechara Kachar
This corrects the article DOI: 10.1038/ncomms10833.
August 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28805050/variability-in-spatially-and-temporally-resolved-emissions-and-hydrocarbon-source-fingerprints-for-oil-and-gas-sources-in-shale-gas-production-regions
#6
David Thomas Allen, Felipe J Cardoso Saldaña, Yosuke Kimura
A gridded inventory for emissions of methane, ethane, propane and butanes, from oil and gas sources in the Barnett Shale production region, has been developed. This inventory extends previous spatially resolved inventories of emissions by characterizing the overall variability in emission magnitudes, and the composition of emissions, at an hourly time resolution. The inventory is divided into continuous and intermittent emission sources. Sources are defined as continuous if hourly averaged emissions are greater than zero in every hour, otherwise they are classified as intermittent...
August 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28803714/building-capacity-for-active-surveillance-of-vaccine-adverse-events-in-the-americas-a-hospital-based-multi-country-network
#7
Pamela Bravo-Alcántara, Silvia Pérez-Vilar, Helvert Felipe Molina-León, Miriam Sturkenboom, Steven Black, Patrick L F Zuber, Christine Maure, Jose Luis Castro
New vaccines designed to prevent diseases endemic in low and middle-income countries are being introduced without prior utilization in countries with robust vaccine pharmacovigilance systems. Our aim was to build capacity for active surveillance of vaccine adverse events in the Americas. We describe the implementation of a proof-of-concept study for the feasibility of an international collaborative hospital-based active surveillance system for vaccine safety. The study was developed and implemented in 15 sentinel sites located in seven countries of the region of the Americas, under the umbrella of the World Health Organization (WHO) Global Vaccine Safety Initiative...
August 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28802116/corrigendum-to-physical-activity-and-sedentary-behavior-in-people-with-major-depressive-disorder-a-systematic-review-and-meta-analysis-j-affect-disord-210-2017-139-150
#8
Felipe Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Philip Ward, Thaís Reichert, Natália Carvalho Bagatini, Roberta Bgeginski, Brendon Stubbs
No abstract text is available yet for this article.
August 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28802081/association-between-creativity-and-physical-fitness-in-primary-school-aged-children
#9
Pedro Ángel Latorre Román, Felipe García Pinillos, Antonio Pantoja Vallejo, Beatriz Berrios Aguayo
AIM: To analyse the relationship between creativity and physical fitness in elementary school children. METHOD: Data were collected from 308 primary school students in southern Spain, ranging in age from 8 to 12 years (M=9.72, SD=1.25). They performed a fitness test battery and the PIC-N questionnaire test was used to analyse creativity. RESULTS: Significant differences were found between sexes. Boys showed better physical fitness but there were no sex differences on creativity...
August 12, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28801910/application-of-synthetic-tumor-specific-promoters-responsive-to-the-tumor-microenvironment
#10
Eduardo G Cafferata, Maria Veronica Lopez, Felipe J Nuñez, Maria A R Maenza, Osvaldo L Podhajcer
Activity of endogenous promoters can be altered by including additional responsive elements (REs). These elements can be responsive to features of the tumor environment or alternatively to signaling pathways specifically activated in cancer cells. These REs incorporated into tumor-specific promoters can improve cancer targeting, the replicative capacity, and lytic activity of conditionally replicative adenovirus. Here we outline an approach to incorporate hypoxia and inflammation REs into a specific fragment of the SPARC promoter and the steps to clone a nucleosome positioning sequence (NPS ) identified in the osteocalcin promoter that contains a Wnt RE upstream of a heterologous synthetic promoter...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28801270/immunomodulatory-effects-and-anti-candida-activity-of-lactobacilli-in-macrophages-and-in-invertebrate-model-of-galleria-mellonella
#11
Felipe Eduardo de Oliveira, Rodnei Dennis Rossoni, Patricia Pimentel de Barros, Barbara Evelyn Begnini, Juliana Campos Junqueira, Antonio Olavo Cardoso Jorge, Mariella Vieira Pereira Leão, Luciane Dias de Oliveira
Due to the growing number of multi-resistant Candida spp., adjuvant treatments that may help combat these fungal pathogens are relevant and useful. This study evaluated the immunomodulation and anti-Candida activity of Lactobacillus rhamnosus (LR), Lactobacillus acidophilus and Lactobacillus paracasei suspensions, either single- or multiple-strain, in mouse macrophages (RAW 264.7) and Galleria mellonella (GM). Mouse macrophages were activated by different lactobacilli suspensions and challenged with C. albicans (CA)...
August 8, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28799458/effects-of-an-unsupervised-pedometer-based-physical-activity-program-on-daily-steps-of-adults-with-moderate-to-severe-asthma-a-randomized-controlled-trial
#12
Cristina Martins Coelho, Maycon Moura Reboredo, Felipe Martins Valle, Carla Malaguti, Larissa Almeida Campos, Lucas Mendes Nascimento, Erich Vidal Carvalho, Júlio César Abreu Oliveira, Bruno Valle Pinheiro
Supervised exercise has shown benefits for subjects with asthma, but little is known about the effectiveness of unsupervised physical activity on this population. We investigated the effects of a 12-week unsupervised pedometer-based physical activity program on daily steps and on clinical and psychological parameters of adults with asthma. Clinically stable adults with moderate to severe asthma were encouraged to take daily 30-minute walks and were randomized to pedometer and control groups. The pedometer group received pedometers and individualized daily step targets...
August 11, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28794974/resting-state-functional-connectivity-changes-due-to-acute-and-short-term-valproic-acid-administration-in-the-baboon-model-of-gge
#13
Felipe S Salinas, Charles Ákos Szabó
Resting-state functional connectivity (FC) is altered in baboons with genetic generalized epilepsy (GGE) compared to healthy controls (CTL). We compared FC changes between GGE and CTL groups after intravenous injection of valproic acid (VPA) and following one-week of orally administered VPA. Seven epileptic (2 females) and six CTL (3 females) baboons underwent resting-state fMRI (rs-fMRI) at 1) baseline, 2) after intravenous acute VPA administration (20 mg/kg), and 3) following seven-day oral, subacute VPA therapy (20-80 mg/kg/day)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28794868/feasibility-and-safety-of-surgical-wound-remote-follow-up-by-smart-phone-in-appendectomy-a-pilot-study
#14
Juan José Segura-Sampedro, Inés Rivero-Belenchón, Verónica Pino-Díaz, María Cristina Rodríguez Sánchez, Felipe Pareja-Ciuró, Javier Padillo-Ruiz, Rosa María Jimenez-Rodriguez
INTRODUCTION: The objective of the present study is to assess the safety and feasibility of the use of telemedicine-based services for surgical wound care and to measure patient satisfaction with telemedicine-based follow-up. MATERIAL AND METHODS: 24 patients were included, they were provided with a corporate mail address. On day 7 after surgery patients sent, via email, an image of their surgical wound together with a completed questionnaire in order to obtain an early diagnosis...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28794478/a-method-based-on-artificial-intelligence-to-fully-automatize-the-evaluation-of-bovine-blastocyst-images
#15
José Celso Rocha, Felipe José Passalia, Felipe Delestro Matos, Maria Beatriz Takahashi, Diego de Souza Ciniciato, Marc Peter Maserati, Mayra Fernanda Alves, Tamie Guibu de Almeida, Bruna Lopes Cardoso, Andrea Cristina Basso, Marcelo Fábio Gouveia Nogueira
Morphological analysis is the standard method of assessing embryo quality; however, its inherent subjectivity tends to generate discrepancies among evaluators. Using genetic algorithms and artificial neural networks (ANNs), we developed a new method for embryo analysis that is more robust and reliable than standard methods. Bovine blastocysts produced in vitro were classified as grade 1 (excellent or good), 2 (fair), or 3 (poor) by three experienced embryologists according to the International Embryo Technology Society (IETS) standard...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794254/sex-specific-stroke-incidence-over-time-in-the-greater-cincinnati-northern-kentucky-stroke-study
#16
Tracy E Madsen, Jane Khoury, Kathleen Alwell, Charles J Moomaw, Eric Rademacher, Matthew L Flaherty, Daniel Woo, Jason Mackey, Felipe De Los Rios La Rosa, Sharyl Martini, Simona Ferioli, Opeolu Adeoye, Pooja Khatri, Joseph P Broderick, Brett M Kissela, Dawn Kleindorfer
OBJECTIVE: Recent data suggest stroke incidence is decreasing over time, but it is unknown whether incidence is decreasing in women and men to the same extent. METHODS: Within our population of 1.3 million, all incident strokes among residents ≥20 years old were ascertained at all hospitals during July 1993-June 1994 and calendar years 1999, 2005, and 2010. A sampling scheme was used to ascertain out-of-hospital cases. Sex-specific incidence rates per 100,000 among black and white participants, age- and race-adjusted, were standardized to the 2000 US Census population...
August 9, 2017: Neurology
https://www.readbyqxmd.com/read/28794154/both-brown-adipose-tissue-and-skeletal-muscle-thermogenesis-processes-are-activated-during-mild-to-severe-cold-adaptation-in-mice
#17
Naresh C Bal, Sushant Singh, Felipe C G Reis, Santosh K Maurya, Sunil Pani, Leslie A Rowland, Muthu Periasamy
Thermogenesis is an important homeostatic mechanism, essential for survival and normal physiological functions in mammals. Both brown adipose tissue (BAT) (i.e. uncoupling protein 1 [UCP1]-based) and skeletal muscle (i.e. sarcolipin [SLN]-based) thermogenesis processes play important roles in temperature homeostasis, but their relative contributions differ from small to large mammals. In this study, we investigated the functional interplay between skeletal muscle and BAT-based thermogenesis under mild versus severe cold adaptation employing UCP1-/- and SLN-/- mice...
August 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28794030/the-investigation-of-promoter-sequences-of-marseilleviruses-highlights-a-remarkable-abundance-of-aaatattt-motif-in-intergenic-regions
#18
Graziele Pereira Oliveira, Maurício Teixeira Lima, Thalita Souza Arantes, Felipe Lopes Assis, Rodrigo Araújo Lima Rodrigues, Flávio Guimarães da Fonseca, Cláudio Antônio Bonjardim, Erna Geessien Kroon, Philippe Colson, Bernard La Scola, Jônatas Santos Abrahão
Viruses display a wide range of genomic profiles and, consequently, a variety of gene expression strategies. Specific sequences associated with transcriptional processes have been described in viruses, and putative promoter motifs have been elucidated for some nucleocytoplasmic large DNA viruses (NCLDV). Among NCLDV, the Marseilleviridae is a well-recognized family because of its genomic mosaicism. The marseilleviruses have an ability to incorporate foreign genes, especially from sympatric organisms inhabiting Acanthamoeba, its main known host...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28792260/phase-i-and-randomized-phase-ii-trial-of-panobinostat-in-combination-with-ice-ifosfamide-carboplatin-etoposide-in-relapsed-or-refractory-classical-hodgkin-lymphoma
#19
Bei Hu, Anas Younes, Jason R Westin, Francesco Turturro, Linda Claret, Lei Feng, Nathan Fowler, Sattva Neelapu, Jorge Romaguera, Fredrick B Hagemeister, Maria Alma Rodriguez, Felipe Samaniego, Luis E Fayad, Amanda R Copeland, Loretta J Nastoupil, Yago Nieto, Michelle A Fanale, Yasuhiro Oki
This phase-I/phase-II study evaluated panobinostat in combination with ifosfamide, carboplatin, etoposide (P-ICE) in relapsed/refractory classical Hodgkin lymphoma. During phase I, panobinostat was given daily on Monday/Wednesday/Friday starting one week prior to Cycle 1 (C1) of ICE and during two weeks of C1-2 of ICE (Schedule A). No DLT was observed at 30 mg. However, frequent (84%) grade-4 thrombocytopenia during second week prompted us to omit the second week of panobinostat 30 mg (Schedule B) for phase II, where this regimen was compared to ICE...
August 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28791178/kelp-and-dolphin-gulls-cause-perineal-wounds-in-south-american-fur-seal-pups-arctocephalus-australis-at-guafo-island-chilean-patagonia
#20
Mauricio Seguel, Francisco Muñoz, Felipe Montalva, Diego Perez-Venegas, Héctor Pavés, Nicole Gottdenker
During five reproductive seasons, we documented the presence, extent and origin of perineal wounds in South American fur seal pups (Arctocephalus australis) on Guafo Island, Northern Chilean Patagonia. The seasonal prevalence of perineal wounds ranged from 5 to 9%, and new cases were more common at the end of the breeding season (February), when pups were on average two months old and were actively expelling hookworms (Uncinaria sp). Histologically, wounds corresponded to marked ulcerative lymphoplasmacytic and histiocytic dermatitis with granulation tissue and mixed bacterial colonies...
July 2017: Royal Society Open Science
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