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https://www.readbyqxmd.com/read/28938024/perspectives-on-invasive-amphibians-in-brazil
#1
Lucas Rodriguez Forti, C Guilherme Becker, Leandro Tacioli, Vânia Rosa Pereira, André Cid F A Santos, Igor Oliveira, Célio F B Haddad, Luís Felipe Toledo
Introduced species have the potential to become invasive and jeopardize entire ecosystems. The success of species establishing viable populations outside their original extent depends primarily on favorable climatic conditions in the invasive ranges. Species distribution modeling (SDM) can thus be used to estimate potential habitat suitability for populations of invasive species. Here we review the status of six amphibian species with invasive populations in Brazil (four domestic species and two imported species)...
2017: PloS One
https://www.readbyqxmd.com/read/28937601/humoral-response-of-buffaloes-to-a-recombinant-vaccine-against-botulism-serotypes-c-and-d
#2
Denis Y Otaka, José D Barbosa, Clóvis Moreira, Marcos R A Ferreira, Carlos E P Cunha, Antônio R S Brito, Rafael A Donassolo, Ângela N Moreira, Fabrício R Conceição, Felipe M Salvarani
Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis. The BoNTs C and D are the main serotypes responsible for botulism in animals, including buffaloes. Botulism is one of the leading causes of death in adult ruminants in Brazil due to the high mortality rates, even though botulism in buffaloes is poorly reported and does not reflect the real economic impact of this disease in Brazilian herds. Vaccination is reported as the most important prophylactic measure for botulism control, although there are no specific vaccines commercially available for buffaloes in Brazil...
September 22, 2017: Toxins
https://www.readbyqxmd.com/read/28937505/measuring-outcomes-in-cataract-surgery
#3
Vivian L Qin, Felipe F Conti, Rishi P Singh
PURPOSE OF REVIEW: The article presents a review of recently published studies reporting postcataract surgery outcomes and the use of electronic systems to track them. RECENT FINDINGS: Current publications report several parameters to measure cataract outcomes such as visual acuity, patient-reported visual function, contrast sensitivity, reading speed, residual refractive errors and complications (intraoperative and postoperative). SUMMARY: Cataracts currently afflict an estimated 94 million people worldwide, and surgical removal is the only effective therapy known...
September 20, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28937502/type-iii-interferons-in-systemic-lupus-erythematosus-association-between-interferon-%C3%AE-3-disease-activity-and-anti-ro-ssa-antibodies
#4
Luis M Amezcua-Guerra, Ricardo Márquez-Velasco, Adriana K Chávez-Rueda, Diana Castillo-Martínez, Felipe Massó, Araceli Páez, Juan Colín-Fuentes, Rafael Bojalil
OBJECTIVE: The aim of this study was to assess associations between serum type III (λ) interferons (IFN-λ) and disease activity in systemic lupus erythematosus (SLE). METHODS: Serum levels of IFN-λ1, IFN-λ2, and IFN-λ3 were measured in 93 SLE patients and 67 healthy individuals. The associations with overall disease activity, organ-specific damage, and SLE-related antibodies were assessed. RESULTS: Median IFN-λ1 levels were 0 pg/mL (range, 0-510 pg/mL) and 0 pg/mL (0-171 pg/mL; P = 0...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937472/type-iii-interferons-in-systemic-lupus-erythematosus-association-between-interferon-%C3%AE-3-disease-activity-and-anti-ro-ssa-antibodies
#5
Luis M Amezcua-Guerra, Ricardo Márquez-Velasco, Adriana K Chávez-Rueda, Diana Castillo-Martínez, Felipe Massó, Araceli Páez, Juan Colín-Fuentes, Rafael Bojalil
OBJECTIVE: The aim of this study was to assess associations between serum type III (λ) interferons (IFN-λ) and disease activity in systemic lupus erythematosus (SLE). METHODS: Serum levels of IFN-λ1, IFN-λ2, and IFN-λ3 were measured in 93 SLE patients and 67 healthy individuals. The associations with overall disease activity, organ-specific damage, and SLE-related antibodies were assessed. RESULTS: Median IFN-λ1 levels were 0 pg/mL (range, 0-510 pg/mL) and 0 pg/mL (0-171 pg/mL; P = 0...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937414/rheumatoid-arthritis-and-citrullination
#6
Erika Darrah, Felipe Andrade
PURPOSE OF REVIEW: Dysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). This article reviews recent literature on the origin of citrullinated antigens in RA. RECENT FINDINGS: The study of synovial fluid from patients with RA has provided important insights into the identity of citrullinated proteins that accumulate in the RA joint (the RA citrullinome) and mechanisms that control their generation...
September 21, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28935936/evidence-of-auditory-insensitivity-to-vocalization-frequencies-in-two-frogs
#7
Sandra Goutte, Matthew J Mason, Jakob Christensen-Dalsgaard, Fernando Montealegre-Z, Benedict D Chivers, Fabio A Sarria-S, Marta M Antoniazzi, Carlos Jared, Luciana Almeida Sato, Luís Felipe Toledo
The emergence and maintenance of animal communication systems requires the co-evolution of signal and receiver. Frogs and toads rely heavily on acoustic communication for coordinating reproduction and typically have ears tuned to the dominant frequency of their vocalizations, allowing discrimination from background noise and heterospecific calls. However, we present here evidence that two anurans, Brachycephalus ephippium and B. pitanga, are insensitive to the sound of their own calls. Both species produce advertisement calls outside their hearing sensitivity range and their inner ears are partly undeveloped, which accounts for their lack of high-frequency sensitivity...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935128/quality-of-life-and-sleep-quality-are-similarly-improved-after-aquatic-or-dry-land-aerobic-training-in-patients-with-type-2-diabetes-a-randomized-clinical-trial
#8
Rodrigo S Delevatti, Felipe Barreto Schuch, Ana Carolina Kanitz, Cristine L Alberton, Elisa Corrêa Marson, Salime Chedid Lisboa, Carolina Dertzbocher Feil Pinho, Luciana Peruchena Bregagnol, Maríndia Teixeira Becker, Luiz Fernando M Kruel
OBJECTIVES: To compare the effects of two aerobic training models in water and on dry-land on quality of life, depressive symptoms and sleep quality in patients with type 2 diabetes. DESIGN: Randomized clinical trial. METHODS: Thirty-five patients with type 2 diabetes were randomly assigned to aquatic aerobic training group (n=17) or dry-land aerobic training group (n=18). Exercise training length was of 12 weeks, performed in three weekly sessions (45min/session), with intensity progressing from 85% to 100% of heart rate of anaerobic threshold during interventions...
September 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28934926/irs-1-py612-and-akt-1-pkb-pt308-phosphorylation-and-antiinflammatory-effect-of-diindolylmethane-in-adipocytes-cocultured-with-macrophages
#9
Lopez-Vazquez Alfonso, Garcia B J Javier, Gonzalez G A Sofía, Urzua L P Ernesto, Del T A Susana, Bueno T M Ruth, Sanchez E Sergio, Munoz V J Francisco, Jave S L Felipe, Armendariz B J Socorro, Bastidas R B Estela
BACKGROUND: 3,3'-Diindolylmethane (DIM) is a condensation product of indole-3-carbinol, a glucosinolate naturally occurring in Brassica genus vegetables. The antiinflammatory properties of DIM through the inhibition of NF-κB, as well as its ameliorating effects on glucose tolerance and hyperglicemic states, have been described. A subclinical proinflammatory profile resultant from the interaction of adipocytes and macrophages have been reported in obesity, affecting the insulin signaling pathway, contributing to insulin resistance...
September 21, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28934481/automatic-identification-of-informative-regions-with-epigenomic-changes-associated-to-hematopoiesis
#10
Enrique Carrillo-de-Santa-Pau, David Juan, Vera Pancaldi, Felipe Were, Ignacio Martin-Subero, Daniel Rico, Alfonso Valencia
Hematopoiesis is one of the best characterized biological systems but the connection between chromatin changes and lineage differentiation is not yet well understood. We have developed a bioinformatic workflow to generate a chromatin space that allows to classify 42 human healthy blood epigenomes from the BLUEPRINT, NIH ROADMAP and ENCODE consortia by their cell type. This approach let us to distinguish different cells types based on their epigenomic profiles, thus recapitulating important aspects of human hematopoiesis...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28933615/role-of-dicer1-in-thyroid-cell-proliferation-and-differentiation
#11
Ricardo Cortez Cardoso Penha, Romina Sepe, Marco De Martino, Francesco Esposito, Simona Pellecchia, Maddalena Raia, Luigi Del Vecchio, Myriam Decaussin-Petrucci, Gabriella De Vita, Luis Felipe Ribeiro Pinto, Alfredo Fusco
DICER1 plays a central role in the biogenesis of microRNAs and it is important for normal development. Altered microRNA expression and DICER1 dysregulation have been described in several types of tumors, including thyroid carcinomas. Recently, our group identified a new somatic mutation (c.5438A>G; E1813G) within DICER1 gene of an unknown function. Herein, we show that DICER1 is overexpressed, at mRNA level, in a significant-relative number of papillary (70%) and anaplastic (42%) thyroid carcinoma samples, whereas is drastically downregulated in all the analyzed human thyroid carcinoma cell lines (TPC-1, BCPAP, FRO and 8505c) in comparison with normal thyroid tissue samples...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28931371/vismapper-ultra-fast-exhaustive-cartography-of-viral-insertion-sites-for-gene-therapy
#12
José M Juanes, Asunción Gallego, Joaquín Tárraga, Felipe J Chaves, Pablo Marín-Garcia, Ignacio Medina, Vicente Arnau, Joaquín Dopazo
BACKGROUND: The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the analysis of integration sites of retroviral vectors is a crucial step in developing safer vectors for therapeutic use. RESULTS: Here we present VISMapper, a vector integration site analysis web server, to analyze next-generation sequencing data for retroviral vector integration sites...
September 20, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28930877/the-impact-of-exercise-induced-muscle-damage-on-performance-test-outcomes-in-elite-female-basketball-players
#13
Kenji Doma, Anthony Leicht, Wade Sinclair, Moritz Schumann, Felipe Damas, Dean Burt, Carl Woods
The purpose of this study was two-fold. First, to examine the impact exercise-induced muscle damage (EIMD) on physical fitness qualities following a basketball-specific training session. Secondly, to determine the reproducibility of the sport-specific performance measures in elite female basketball players. Ten elite female basketball players (age 25.6 ± 4.5 years; height 1.8 ± 0.7m; body mass 76.7 ± 8.3kg) undertook a 90-minute training session involving repeated jumping, sprinting and game-simulated training...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28928628/axonal-degeneration-during-aging-and-its-functional-role-in-neurodegenerative-disorders
#14
REVIEW
Natalia Salvadores, Mario Sanhueza, Patricio Manque, Felipe A Court
Aging constitutes the main risk factor for the development of neurodegenerative diseases. This represents a major health issue worldwide that is only expected to escalate due to the ever-increasing life expectancy of the population. Interestingly, axonal degeneration, which occurs at early stages of neurodegenerative disorders (ND) such as Alzheimer's disease, Amyotrophic lateral sclerosis, and Parkinson's disease, also takes place as a consequence of normal aging. Moreover, the alteration of several cellular processes such as proteostasis, response to cellular stress and mitochondrial homeostasis, which have been described to occur in the aging brain, can also contribute to axonal pathology...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28928159/bmp4-induces-m2-macrophage-polarization-and-favors-tumor-progression-in-bladder-cancer
#15
Víctor G Martínez, Carolina Rubio, Mónica Martínez-Fernández, Cristina Segovia, Fernando López-Calderón, Marina Garín, Alicia Teijeira, Ester Munera-Maravilla, Alberto Varas, Rosa Sacedón, Felix Guerrero-Ramos, Felipe Villacampa, Federico de la Rosa, Daniel Castellano, Eduardo López-Collazo, Jesus M Paramio, Ángeles Vicente, Marta Dueñas
PURPOSE: Bladder cancer (BC) is a current clinical and social problem. At diagnosis, most patients present non-muscle invasive tumors, characterized by a high recurrence rate, which could progress to muscle invasive disease and metastasis. Bone morphogenetic protein (BMP)-dependent signaling arising from stromal bladder tissue mediates urothelial homeostasis by promoting urothelial cell differentiation. However, the possible role of BMP ligands in BC is still unclear. EXPERIMENTAL DESIGN: Tumor and normal tissue from 68 patients with urothelial cancer were prospectively collected and analyzed for expression of BMP and macrophage markers...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28926992/the-native-fruit-geoffroea-decorticans-from-arid-northern-chile-phenolic-composition-antioxidant-activities-and-in-vitro-inhibition-of-pro-inflammatory-and-metabolic-syndrome-associated-enzymes
#16
Felipe Jiménez-Aspee, Cristina Theoduloz, Maria Del Pilar C Soriano, Maider Ugalde-Arbizu, Maria Rosa Alberto, Iris Catiana Zampini, Maria Inés Isla, Mario J Simirigiotis, Guillermo Schmeda-Hirschmann
The native tree Geoffroea decorticans (chañar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean chañar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92...
September 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925880/antileukemic-properties-of-sesquiterpene-lactones-a-systematic-review
#17
Elaine da Silva Castro, Lívia Azeredo Alves Antunes, Jonathas Felipe Revoredo Lobo, Norman Arthur Ratcliffe, Ricardo Moreira Borges, Leandro Rocha, Patrícia Federal Burth, Lidia Maria Fonte Amorim
This review summarizes the reported molecular mechanisms underlying the antileukemic property of Sesquiterpene Lactones (SLs). This systematic review was registered in the PROSPERO database and conducted following the PRISMA Statements. The MeSH terms, Sesquiterpenes, Lactones and Leukemia were used in four databases (Pubmed, Web of Science, Scopus and Bireme). There were 281 studies selected, but after exclusions, due to replication (n = 172) or not following PECOS criteria (n = 24), 148 studies remained. Of the 148 articles, only 22 were submitted to quality assessment and were scored in high level if more than two techniques, to elucidate antileukemic proprieties, were described, and then data were extracted...
September 18, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28925032/susceptibility-of-malassezia-pachydermatis-to-aminoglycosides
#18
Freddy Alejandro Silva, Magnolia Conde-Felipe, Inmaculada Rosario, Otilia Ferrer, Fernando Real, Soraya Déniz, Félix Acosta, Daniel Padilla, Begoña Acosta-Hernández
Previous studies have evaluated the action of gentamicin against Malassezia pachydermatis. The aim of this study was to evaluate in vitro susceptibility of M. pachydermatis to the aminoglycosides- gentamicin, tobramycin, netilmicin and framycetin. The minimum inhibitory concentration (MIC) of gentamicin was determined following methods M27-A3 microdilution and Etest(®) . The Etest(®) was used to determine the minimum inhibitory concentration (MIC) of the tobramycin and netilmicin. The Kirby-Bauer test was used to determine the antibiotic susceptibility to the framycetin...
September 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28923297/quick-analysis-of-organic-matter-in-soil-by-energy-dispersive-x-ray-fluorescence-and-multivariate-analysis
#19
Franslley Morona, Felipe R Dos Santos, André M Brinatti, Fábio L Melquiades
The rapid, simple and accurate determination of soil quality indicators is fundamental for improvements in precision agriculture and consequently in production efficiency. The objectives of this study were to determine the organic matter (OM) and total organic carbon (TOC) concentrations in agricultural soil and to discriminate soil provenance by energy-dispersive X-ray fluorescence (EDXRF) combined with principal component analysis and partial least square regression. The conventional methods used for the determination of OM and TOC concentrations are the gravimetric and Walkley-Black methods, respectively...
September 8, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28923048/implementation-of-a-smartphone-application-in-medical-education-a-randomised-trial-istart
#20
Felipe Martínez, Catalina Tobar, Carla Taramasco
No abstract text is available yet for this article.
September 18, 2017: BMC Medical Education
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