Peter Tougaard, Mario R Pérez, Wolf Steels, Jelle Huysentruyt, Bruno Verstraeten, Jessica Vetters, Tatyana Divert, Amanda Gonçalves, Ria Roelandt, Nozomi Takahashi, Sophie Janssens, Terkild B Buus, Tom Taghon, Georges Leclercq, Peter Vandenabeele
Acute thymic atrophy occurs following type 1 inflammatory conditions such as viral infection and sepsis, resulting in cell death and disruption of T cell development. However, the impact type 1 immunity has on thymic-resident innate lymphoid cells (ILCs) remains unclear. Single-cell RNA sequencing revealed neonatal thymic-resident type 1 ILCs (ILC1s) as a unique and immature subset compared to ILC1s in other primary lymphoid organs. Culturing murine neonatal thymic lobes with the type 1 cytokines interleukin-12 (IL-12) and IL-18 resulted in a rapid expansion and thymic egress of KLRG1+ CXCR6+ cytotoxic ILC1s...
January 19, 2024: Science Advances