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Cytomegalovirus infection neonatal

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https://www.readbyqxmd.com/read/28225480/nmda-receptor-subunit-and-camkii-changes-in-rat-hippocampus-by-congenital-hcmv-infection-a-mechanism-for-learning-and-memory-impairment
#1
De Wu, Li Yang, Xiaosong Bu, Jiulai Tang, Xiaocheng Fan
The aim of this study was to investigate the effects of congenital human cytomegalovirus infection on the expression levels of N-methyl-D-aspartate receptors (NRs) and Ca/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal neurons of neonatal Sprague-Dawley (SD) rats. Pregnant SD rats were divided into an experimental group and a control group (n=10 in each group). Spatial learning and memory of the offspring of SD rats were evaluated using the Morris water-maze test. Pathological studies of hippocampus sections were carried out...
February 20, 2017: Neuroreport
https://www.readbyqxmd.com/read/28223455/acute-fetal-demise-with-first-trimester-maternal-infection-resulting-from-listeria-monocytogenes-in-a-nonhuman-primate-model
#2
Bryce Wolfe, Gregory J Wiepz, Michele Schotzko, Gennadiy I Bondarenko, Maureen Durning, Heather A Simmons, Andres Mejia, Nancy G Faith, Emmanuel Sampene, Marulasiddappa Suresh, Sophia Kathariou, Charles J Czuprynski, Thaddeus G Golos
Infection with Listeria monocytogenes during pregnancy is associated with miscarriage, preterm birth, and neonatal complications, including sepsis and meningitis. While the risk of these conditions is thought to be greatest during the third trimester of pregnancy, the determinants of fetoplacental susceptibility to infection, the contribution of gestational age, and the in vivo progression of disease at the maternal-fetal interface are poorly understood. We developed a nonhuman primate model of listeriosis to better understand antecedents of adverse pregnancy outcomes in early pregnancy...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28222150/polymorphisms-and-features-of-cytomegalovirus-ul144-and-ul146-in-congenitally-infected-neonates-with-hepatic-involvement
#3
Gangqiang Guo, Liang Zhang, Sisi Ye, Yingying Hu, Baoqing Li, Xiangwei Sun, Chenchen Mao, Jianfeng Xu, Yiping Chen, Lifang Zhang, Xiangyang Xue
Human cytomegalovirus is a significant agent of hepatic involvement in neonates. In this study, we investigated the polymorphisms and features of the viral genes UL144 and UL146 as well as their significance to congenital hepatic involvement. In 79 neonates with congenital cytomegalovirus infection and hepatic involvement, full length UL144 and UL146 were successfully amplified in 73.42% and 60.76% of cases, respectively. Sequencing indicated that both genes were hypervariable. Notably, UL144 genotype B was highly associated with aspartate aminotransferase (P = 0...
2017: PloS One
https://www.readbyqxmd.com/read/28219832/the-role-of-single-nucleotide-polymorphisms-contained-in-proinflammatory-cytokine-genes-in-the-development-of-congenital-infection-with-human-cytomegalovirus-in-fetuses-and-neonates
#4
Wioletta Wujcicka, Jan Wilczyński, Dorota Nowakowska
PURPOSE: The research project targeted the distribution of genotypes, alleles and haplotypes in single nucleotide polymorphisms (SNPs) within the interleukin (IL) 1A, IL1B, IL6, IL12B and TNFA genes, in fetuses and neonates, congenitally infected with human cytomegalovirus (HCMV), and among uninfected controls. METHODS: The study included 20 fetuses and neonates with congenital HCMV infection and 31 control individuals. The genotypes in SNPs of the studied cytokine genes were identified by a self-designed nested PCR-RFLP assays...
February 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28211317/primary-human-cytomegalovirus-hcmv-infection-in-pregnancy
#5
Horst Buxmann, Klaus Hamprecht, Matthias Meyer-Wittkopf, Klaus Friese
BACKGROUND: In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain, leading to motor and mental retardation, cerebral palsy, epilepsy, retinal defects, and progressive hearing loss. METHODS: This review is based on pertinent publications from January 2000 to October 2016 that were retrieved by a selective search in PubMed employing the terms "cytomegalovirus and pregnancy" and "congenital cytomegalovirus...
January 27, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28195113/congenital-cytomegalovirus-infection-in-a-neonate-born-to-hiv-infected-mother-a-case-report
#6
Dhaneshwar Namdeorao Lanjewar, Sushma Nagsen Ramraje
No abstract text is available yet for this article.
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28179532/a-murine-herpesvirus-closely-related-to-ubiquitous-human-herpesviruses-causes-t-cell-depletion
#7
Swapneel J Patel, Guoyan Zhao, Vinay R Penna, Eugene Park, Elvin J Lauron, Ian B Harvey, Wandy L Beatty, Beatrice Plougastel-Douglas, Jennifer Poursine-Laurent, Daved H Fremont, David Wang, Wayne M Yokoyama
Mouse models of human herpesvirus infections The human roseoloviruses HHV6A, HHV6B, and HHV7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many diseases; however, it has been challenging to establish infections with Roseoloviruses as direct drivers of pathology because they are nearly ubiquitous and display species-specific tropism. Furthermore, controlled study of infection has been hampered by the lack of experimental models, and until now, a mouse roseolovirus has not been identified...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28168206/passive-immunoprophylaxis-for-the-protection-of-the-mother-and-her-baby-insights-from-in-vivo-models-of-antibody-transport
#8
Yanqun Xu, Iftekhar Mahmood, Lilin Zhong, Pei Zhang, Evi B Struble
Pregnant women are at high risk for infection by pathogens. Vertical transmission of infectious agents, such as Zika, hepatitis B, and cytomegalovirus during pregnancy, remains a public health problem, associated with dire outcomes for the neonate. Thus, a safe prophylactic and therapeutic approach for protecting the mother and the neonate from infections remains a high priority. Our work is focused on better understanding the safety and efficacy determinants of IgG antibody preparations when used during pregnancy to benefit the mother and her baby...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28118851/tlr2-2258-g-a-single-nucleotide-polymorphism-and-the-risk-of-congenital-infection-with-human-cytomegalovirus
#9
Wioletta Wujcicka, Edyta Paradowska, Mirosława Studzińska, Jan Wilczyński, Dorota Nowakowska
BACKGROUND: Human cytomegalovirus (HCMV) is responsible for the most common intrauterine infections, which may be acquired congenitally from infected pregnant woman to fetus. The research was aimed to estimate the role of three single nucleotide polymorphisms (SNPs) located in TLR2 gene, and the common contribution of TLR2, and previously studied TLR4 and TLR9 SNPs, to the occurrence of congenital HCMV infection in fetuses and newborns. METHODS: The study was performed in 20 Polish fetuses and newborns, congenitally infected with HCMV, and in 31 uninfected controls, as well as with participation of pregnant women, the mothers of 16 infected and 14 uninfected offsprings...
January 24, 2017: Virology Journal
https://www.readbyqxmd.com/read/28081328/cytomegalovirus-hepatitis-in-49-pediatric-patients-with-normal-immunity
#10
Hasan Tezer, Saliha Kanık Yüksek, Belgin Gülhan, Aslı Nur Özkaya Parlakay, Ceyda Tuna Kırsaçlıoğlu
BACKGROUND/AIM: Cytomegalovirus (CMV) hepatitis is generally asymptomatic or rarely can lead to severe complications in immunocompetent hosts. This study aims to evaluate CMV hepatitis in immunocompetent young children, which is discussed relatively rarely in the literature. MATERIALS AND METHODS: A retrospective review of 49 pediatric patients with CMV hepatitis from January 2005 to December 2010 was performed. RESULTS: The median age of the patients was 5...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079113/congenital-hearing-loss
#11
REVIEW
Anna M H Korver, Richard J H Smith, Guy Van Camp, Mark R Schleiss, Maria A K Bitner-Glindzicz, Lawrence R Lustig, Shin-Ichi Usami, An N Boudewyns
Congenital hearing loss (hearing loss that is present at birth) is one of the most prevalent chronic conditions in children. In the majority of developed countries, neonatal hearing screening programmes enable early detection; early intervention will prevent delays in speech and language development and has long-lasting beneficial effects on social and emotional development and quality of life. A diagnosis of hearing loss is usually followed by a search for an underlying aetiology. Congenital hearing loss might be attributed to environmental and prenatal factors, which prevail in low-income settings; congenital infections, particularly cytomegalovirus infection, are also a common risk factor for hearing loss...
12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28056855/symptomatic-congenital-cytomegalovirus-disease-following-non-primary-maternal-infection-a-retrospective-cohort-study
#12
Eran Hadar, Elizabeta Dorfman, Ron Bardin, Rinat Gabbay-Benziv, Jacob Amir, Joseph Pardo
BACKGROUND: Scarce data exist about screening, diagnosis and prognosis of non-primary Cytomegalovirus (CMV) during pregnancy. We aimed to examine antenatal diagnosis of maternal non-primary CMV infection and to identify risk factors for congenial CMV disease. METHODS: Retrospective cohort of 107 neonates with congenital symptomatic CMV infection, following either primary (n = 95) or non-primary (n = 12) maternal CMV infection. We compared the groups for the manifestations and severity of congenial CMV disease, as well as for possible factors associated with the risk of developing CMV related infant morbidity...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28049114/a-targeted-approach-for-congenital-cytomegalovirus-screening-within-newborn-hearing-screening
#13
Karen B Fowler, Faye P McCollister, Diane L Sabo, Angela G Shoup, Kris E Owen, Julie L Woodruff, Edith Cox, Lisa S Mohamed, Daniel I Choo, Suresh B Boppana
BACKGROUND AND OBJECTIVE: Congenital cytomegalovirus (cCMV) infection remains a leading cause of childhood hearing loss. Currently universal CMV screening at birth does not exist in the United States. An alternative approach could be testing infants who do not pass their newborn hearing screening (NHS) for cCMV. This study was undertaken to evaluate whether a targeted approach will identify infants with CMV-related sensorineural hearing loss (SNHL). METHODS: Infants born at 7 US medical centers received NHS and were also screened for cCMV while in the newborn nursery...
February 2017: Pediatrics
https://www.readbyqxmd.com/read/28034524/maternal-immunoglobulin-g-avidity-as-a-diagnostic-tool-to-identify-pregnant-women-at-risk-of-congenital-cytomegalovirus-infection
#14
Masatoki Kaneko, Masanao Ohhashi, Toshio Minematsu, Junsuke Muraoka, Kazumi Kusumoto, Hiroshi Sameshima
BACKGROUND: The immunoglobulin (Ig) G avidity index (AI) is useful to detect primary cytomegalovirus (CMV) infection. However, because IgG matures with time, this index is not useful to detect a primary infection, unless measured at an appropriate time. OBJECTIVES: We aimed to clarify the difference between using IgG AI and IgM positivity according to the stage of pregnancy to identify congenital CMV infection risk. STUDY DESIGN: We collected the serum samples from 1115 pregnant women who underwent maternal screening for primary infection (n = 956) and were referred to our hospital because of CMV IgM positivity (n = 155) or had abnormal fetal ultrasonography findings (n = 4)...
December 26, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28033238/congenital-cytomegalovirus-infection-and-permanent-hearing-loss-in-rural-north-indian-children
#15
Lalit Dar, Divya Namdeo, Pankaj Kumar, Alok Thakar, Shashi Kant, Sanjay Rai, Pawan K Singh, Madhulika Kabra, Karen B Fowler, Suresh B Boppana
BACKGROUND: Congenital cytomegalovirus infection (cCMV) is a leading non-genetic cause of permanent congenital or early-onset hearing loss (PCEHL). Although cCMV rates are high despite near-universal seroimmunity, the contribution of cCMV to PCEHL in the developing world is unclear. METHODS: Neonates at a rural north Indian hospital were screened for cCMV by saliva PCR and hearing by distortion product otoacoustic emission (DPOAE) testing. CMV positive infants and those not passing newborn hearing screening (NHS) were evaluated by auditory brainstem response to confirm PCEHL...
December 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28009139/neonatal-gastrointestinal-involvement-and-congenital-cytomegalovirus
#16
Alessandro Porta, Adriana Avanzini, Marta Bellini, Rosa Maria Crossignani, Stefano Fiocchi, Stefano Martinelli, Luciana Parola
Cytomegalovirus (CMV) is the most common cause of congenital viral infection, affecting 0.2 to 2.3% of all live births in developed countries. Very low birth weight and extremely low birth weight newborns are at higher risk of symptomatic CMV infection, most commonly secondary and acquired through breast milk. Gastrointestinal involvement is rare in acquired CMV infections, but it could be an important manifestation of postnatal infection in preterm infants admitted to neonatal intensive care units. Early onset of CMV gastrointestinal signs/symptoms is very rare...
November 28, 2016: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/28008743/fatal-cytomegalovirus-infection-following-cardiac-surgery-in-a-neonate-with-asplenia
#17
Tomomi Hasegawa, Yoshihiro Oshima, Mayuko Yamamoto, Yumi Sato
No abstract text is available yet for this article.
December 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28006975/positive-igm-in-congenital-cmv-infection
#18
Efraim Bilavsky, Salmas Watad, Itzhak Levy, Nehama Linder, Joseph Pardo, Haim Ben-Zvi, Joseph Attias, Jacob Amir
Neonatal serum detection of cytomegalovirus (CMV) immunoglobulin M (IgM) has low sensitivity in identifying congenital cytomegalovirus (cCMV). Several reports have endeavored to associate the presence/absence of IgM to disease severity. Data were collected for all infants with cCMV followed in our clinic. Infant outcome after birth was compared between infants who tested positive or negative. Sensitivity of positive IgM in diagnosing cCMV was 40.7%. The rate of symptomatic disease in those who tested positive was statistically higher (67...
December 1, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27999698/necrotizing-retinitis-secondary-to-congenital-cytomegalovirus-infection-associated-with-severe-combined-immunodeficiency
#19
Pehmen Yasin Ozcan, Hasan Tolga Celik, Kenan Sonmez, Melda Celik
A 20-day-old male infant who was born at 39 weeks of gestation was admitted to neonatal intensive care unit due to severe respiratory insufficiency. In retinal examination, peripheric retinal white-black color areas that correspond to necrotizing retinitis, moderate vitritis, macular and optic nerve head involvement, vascular leakage, and sheathing indicating perivasculitis were revealed. Despite the fact that CMV specific IgM was undetectable, CMV DNA with high viral load was found in his blood sample by means of real-time polymerase chain reaction assay...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27931021/a-retrospective-analysis-of-neonatal-encephalocele-predisposing-factors-and-outcomes
#20
Seyho Cem Yucetas, Necati Uçler
OBJECTIVE: This study evaluates the predisposing factors and outcomes of surgical management of encephaloceles at our institution. MATERIALS AND METHODS: A retrospective analysis of 32 occipital encephaloceles managed operatively at the Neurosurgery Department Clinics of the Faculty of Medicine, Adıyaman University, was performed between 2011 and 2015. RESULTS: Among the study population, 19 mothers had been exposed to TORCH infections (toxoplasma, rubella, cytomegalovirus, herpes simplex virus), 18 were in consanguineous marriages, and 3 had regular prenatal screening...
December 9, 2016: Pediatric Neurosurgery
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