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Neutropenia newborn

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https://www.readbyqxmd.com/read/29451309/antibodies-to-human-neutrophil-antigen-hna-3b-implicated-in-cases-of-neonatal-alloimmune-neutropenia
#1
Larissa Barbosa Lopes, Samira Ali Abbas, Elyse Moritz, Juliana Oliveira Martins, Akemi Kuroda Chiba, Dante Mário Langhi, José O Bordin
BACKGROUND: Neonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a; however, to date, antibodies specific to HNA-3b have not been reported. STUDY DESIGN AND METHODS: Blood samples from 10,000 unselected neonates were analyzed, resulting in the selection of 88 neutropenic newborns (neutrophil count <1...
February 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29113524/how-does-preeclampsia-affect-neonates-highlights-in-the-disease-s-immunity
#2
Lina R Marins, Leonardo B Anizelli, Mariana D Romanowski, Ana L Sarquis
INTRODUCTION: Preeclampsia (PE) is the primary obstetrical cause in one of the four perinatal deaths. Although the etiology and pathogenesis of preeclampsia is not fully known, a proinflammatory immune state prevails and can disrupt fetal hematopoiesis. Some of the effects on the newborn include neonatal thrombocytopenia, neutropenia, a reduction in T regulatory cells, and an increased cytotoxic natural killer cell profile. METHODS: Electronic databases were searched, and defined criteria were applied to select articles for review...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28969890/lactobacillus-reuteri-for-infants-with-colic-a-double-blind-placebo-controlled-randomized-clinical-trial
#3
RANDOMIZED CONTROLLED TRIAL
Nicole Y Fatheree, Yuying Liu, Christopher M Taylor, Thomas K Hoang, Chunyan Cai, Mohammad H Rahbar, Manouchehr Hessabi, Michael Ferris, Valarie McMurtry, Christine Wong, Ta Vu, Theresa Dancsak, Ting Wang, Wallace Gleason, Vinay Bandla, Fernando Navarro, Dat Q Tran, J Marc Rhoads
OBJECTIVE: To assess the safety of probiotic Lactobacillus reuteri strain Deutsche Sammlung von Mikroorganismen (DSM) 17938 with daily administration to healthy infants with colic and to determine the effect of L reuteri strain DSM 17938 on crying, fussing, inflammatory, immune, and microbiome variables. STUDY DESIGN: We performed a controlled, double-blinded, phase 1 safety and tolerability trial in healthy breast-fed infants with colic, aged 3 weeks to 3 months, randomly assigned to L reuteri strain DSM 17938 (5 × 108 colony-forming units daily) or placebo for 42 days and followed for 134 days...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28892906/changes-in-haematological-parameters-in-newborns-born-to-preeclamptic-mothers-a-case-control-study-in-a-rural-hospital
#4
Kalavakuru Mouna, Shilpa Manigatta Doddagowda, Krishnappa Junjegowda, Latha Krishnamurthy
INTRODUCTION: Pregnancy is a physiological phenomenon. However, some women develop problems during pregnancy period, which puts both the mother's and the foetus health at risk. Hypertensive disorders of pregnancy are the type of the maternal diseases that can cause the most detrimental effects to the mother and foetus. AIMS: To determine the haematological parameters in neonates born to preeclamptic mothers. MATERIALS AND METHODS: It was a prospective case control study carried out on neonates born to preeclamptic mothers in our institute from March 2016 to November 2016...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28685094/treatment-of-high-grade-osteoblastic-osteosarcoma-of-the-humerus-in-a-5-year-old-boy-with-cystic-fibrosis-a-case-report
#5
Kenichi V Okuda, Jutta Hammermann, Björn S Lange, Jana C Fischer, Falk Thielemann, Ralf Knöfler, Meinolf Suttorp
Antineoplastic treatment of osteoblastic osteosarcoma in a patient with cystic fibrosis (CF) may harbor a high risk of neutropenia-associated complications, and, to the best of our knowledge, has not been previously reported. Diagnosis of CF was confirmed in a 6-week-old boy following pathological newborn screening. The patient had a stable course of CF under standardized continuous therapy. At the age of 5 years, osteosarcoma of the left proximal humerus was diagnosed without evidence of metastases. Neoadjuvant chemotherapy, including doxorubicin, cisplatin and methotrexate, was administered for 10 weeks...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28168815/descriptive-study-of-the-complete-blood-count-in-newborn-infants-with-down-syndrome
#6
Francisco Javier Martínez-Macías, Lucina Bobadilla-Morales, Janet González-Cruz, Moisés Quiles-Corona, Alfredo Corona-Rivera, Christian Peña-Padilla, Mireya Orozco-Vela, Rocío Silva-Cruz, Fernando Velarde-Rivera, Jorge Román Corona-Rivera
The usefulness of the complete blood count (CBC) during the first week of life in infants with Down syndrome (DS) has been recognized; however, studies are limited and have evaluated only some of the parameters of the CBC. Here, we report a prospective study of 135 infants with cytogenetically confirmed DS and a reference group of 226 infants without birth defects all born during the period 2009-2015 at the Dr. Juan I. Menchaca Civil Hospital of Guadalajara (Guadalajara, Mexico). The goal was to evaluate hematological findings in the CBC during the first 7 days of life, interpreted according to gestational and postnatal age...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28151845/high-frequency-of-bone-marrow-depression-during-congenital-toxoplasmosis-therapy-in-a-cohort-of-children-identified-by-neonatal-screening-in-minas-gerais-brazil
#7
Ericka Viana Machado Carellos, Juliana Queiroz de Andrade, Roberta Maia Castro Romanelli, Jacqueline Domingos Tibúrcio, José Nélio Januário, Daniel Vítor Vasconcelos-Santos, Rosângela Maria Figueiredo, Gláucia Manzan Queiroz de Andrade
BACKGROUND: There are few studies reporting frequency and control of adverse events associated with congenital toxoplasmosis treatment. The objective of this study is to describe treatment adherence and adverse hematologic events in a cohort of children identified with congenital toxoplasmosis in Minas Gerais, Brazil. METHODS: Children were treated with sulfadiazine, pyrimethamine and folinic acid and were evaluated clinically and by laboratory tests at regular intervals...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27754968/a-unique-case-of-shwachman-diamond-syndrome-presenting-with-congenital-hypopituitarism
#8
Nurin Jivani, Carmen Torrado-Jule, Sarah Vaiselbuh, Eleny Romanos-Sirakis
Shwachman-Diamond syndrome (SDS) is an autosomal recessive bone marrow failure syndrome typically characterized by neutropenia and pancreatic dysfunction, although phenotypic presentations vary, and the endocrine phenotype is not well-described. We report a unique case of a patient with SDS who initially presented with hypoglycemia and micropenis in the newborn period and was diagnosed with congenital hypopituitarism. We are not aware of any other cases of SDS documented with this combination of complex endocrinopathies...
November 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27751427/successful-treatment-with-granulocyte-colony-stimulating-factor-for-ritodrine-induced-neutropenia-in-a-twin-pregnancy
#9
Chen-Yu Wang, Yu-Ju Lai, Kwei-Shuai Hwang, Chi-Huang Chen, Mu-Hsien Yu, Huei-Tsung Chen, Her-Young Su
OBJECTIVE: Neutropenia developed after continuous intravenous infusion of ritodrine hydrochloride (Yutopar) for preterm uterine contractions in a twin pregnancy. We successfully returned the low neutrophil count to the normal range after discontinuation of infusion of ritodrine and treatment with granulocyte colony stimulating factor (G-CSF). CASE REPORT: A 34-year-old woman with twin pregnancy was treated with ritodrine for preterm uterine contractions at 27 weeks and 6 days gestation...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27638133/management-of-neutropenic-patients-in-the-intensive-care-unit-newborns-excluded-recommendations-from-an-expert-panel-from-the-french-intensive-care-society-srlf-with-the-french-group-for-pediatric-intensive-care-emergencies-gfrup-the-french-society-of-anesthesia
#10
REVIEW
David Schnell, Elie Azoulay, Dominique Benoit, Benjamin Clouzeau, Pierre Demaret, Stéphane Ducassou, Pierre Frange, Matthieu Lafaurie, Matthieu Legrand, Anne-Pascale Meert, Djamel Mokart, Jérôme Naudin, Frédéric Pene, Antoine Rabbat, Emmanuel Raffoux, Patricia Ribaud, Jean-Christophe Richard, François Vincent, Jean-Ralph Zahar, Michael Darmon
Neutropenia is defined by either an absolute or functional defect (acute myeloid leukemia or myelodysplastic syndrome) of polymorphonuclear neutrophils and is associated with high risk of specific complications that may require intensive care unit (ICU) admission. Specificities in the management of critically ill neutropenic patients prompted the establishment of guidelines dedicated to intensivists. These recommendations were drawn up by a panel of experts brought together by the French Intensive Care Society in collaboration with the French Group for Pediatric Intensive Care Emergencies, the French Society of Anesthesia and Intensive Care, the French Society of Hematology, the French Society for Hospital Hygiene, and the French Infectious Diseases Society...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27374781/acr-appropriateness-criteria-fever-without-source-or-unknown-origin-child
#11
Sjirk J Westra, Boaz K Karmazyn, Adina L Alazraki, Molly E Dempsey, Jonathan R Dillman, Matthew Garber, Sheila G Moore, Molly E Raske, Henry E Rice, Cynthia K Rigsby, Nabile Safdar, Stephen F Simoneaux, Peter J Strouse, Andrew T Trout, Sandra L Wootton-Gorges, Brian D Coley
The cause of fever in a child can often be determined from history, physical examination, and laboratory tests; infections account for the majority of cases. Yet in 20%, no apparent cause can be found, designated as fever without source (FWS). The yield of chest radiography in children with FWS is low, and it is usually not appropriate. However, in children with respiratory signs, high fever (>39°C), or marked leukocytosis (≥20,000/mm(3)), chest radiography is usually appropriate, as it has a higher yield in detecting clinically occult pneumonia...
August 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27116911/diagnostic-value-of-soluble-triggering-receptor-expressed-on-myeloid-cells-in-paediatric-sepsis-a-systematic-review
#12
REVIEW
Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Francesca Calò Carducci, Alessandro Jenkner, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Alessandra Simonetti, Elena Ferretti, Martina Della Corte, Luca Gramatica, Susanna Livadiotti, Paolo Rossi
BACKGROUND: Differential diagnosis between sepsis and non-infectious inflammatory disorders demands improved biomarkers. Soluble Triggering Receptor Expression on Myeloid cells (sTREM-1) is an activating receptor whose role has been studied throughout the last decade. We performed a systematic review to evaluate the accuracy of plasma sTREM-1 levels in the diagnosis of sepsis in children with Systemic Inflammatory Response Syndrome (SIRS). METHODS: A literature search of PubMed, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and ISI Web of Knowledge databases was performed using specific search terms...
April 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26906163/treatment-of-congenital-toxoplasmosis-safety-of-the-sulfadoxine-pyrimethamine-combination-in-children-based-on-a-method-of-causality-assessment
#13
Julie Teil, Damien Dupont, Bruno Charpiat, Stéphane Corvaisier, Thierry Vial, Gilles Leboucher, Martine Wallon, François Peyron
BACKGROUND: The treatment of newborns and infants with congenital toxoplasmosis is standard practice. Some observational studies have examined safety in newborns, but most of these failed to provide sufficient details for a provisional assessment of causality. The aim of this study was to evaluate the clinical and biological adverse effects of the combination of sulfadoxine-pyrimethamine. METHODS: Sixty-five children treated for 1 year with a combination of sulfadoxine-pyrimethamine (1 dose every 10 days) for congenital toxoplasmosis were followed up to evaluate abnormal hematological values and potential adverse events using a standardized method of causality assessment...
June 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26642867/challenges-in-vaccinating-infants-born-to-mothers-taking-immunoglobulin-biologicals-during-pregnancy
#14
REVIEW
Juejing Ling, Gideon Koren
While immunoglobulin biologicals are increasingly used during pregnancy, there have been concerns on the immune function and vaccination of infants born to mothers taking immunoglobulin biologicals. In addition to the detection of biologicals in cord blood, cases of severe neonatal neutropenia and fatal dissemination of Bacillus Calmette-Guérin (BCG) have been reported. With increasing number of infants exposed to immunoglobulin biologicals in utero, there is a need to address the challenges in vaccinating these infants...
2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/26500973/evaluation-of-cord-blood-haematological-scoring-system-as-an-early-predictive-screening-method-for-the-detection-of-early-onset-neonatal-sepsis
#15
Vamseedhar Annam, Vijayashree Medarametla, Nalinimohan Chakkirala
BACKGROUND: Sepsis is one of the major causes of neonatal morbidity and mortality. Early recognition and diagnosis of neonatal sepsis are difficult because of the variable and non-specific clinical presentation of this condition. Hence, there is a need for early predictive screening method for neonatal sepsis. OBJECTIVES: To evaluate the role of Cord blood Haematological Scoring System as an early predictive screening method for detection of early onset neonatal sepsis and also to identify the neonates who are at risk of developing neonatal sepsis using cord blood...
September 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26195545/recurrence-of-neonatal-lupus-post-cord-blood-transplant-for-severe-congenital-neutropenia
#16
Ashley K Shaver, Kelly Walkovich, James A Connelly
Neonatal lupus erythematosus (NLE) is a rare autoimmune disorder associated with transplacental migration of maternal autoantibodies against SS-A (Ro) or SS-B (La) antigens that results in cardiac, hepatic, cutaneous, and hematologic manifestations. Although NLE-associated neutropenia is considered transient and benign, neutropenia caused by severe congenital neutropenia (SCN) is life-threatening. Diagnosing a complicated picture of neonatal neutropenia can be challenging because there are many overlapping features between the acquired and inherited etiologies...
August 2015: Pediatrics
https://www.readbyqxmd.com/read/25984613/-cytomegalovirus-congenital-infection-and-clinical-presentation-in-infants-with-respiratory-distress-syndrome
#17
Angélica Martínez-Contreras, Rosalía Lira, Carmen Soria-Rodríguez, Sawako Hori-Oshima, Angélica Maldonado-Rodríguez, Othón Rojas-Montes, Rafael Ayala-Figueroa, Julia Estrada-Guzmán, Ma Teresa Álvarez-Muñoz
BACKGROUND: Respiratory distress syndrome (RDS) is a multifactorial and common disease that varies from 15 to 50 % in the newborn, causing 50 % of mortality. The RDS may be associated with bacterial and viral infections, and one of the most common viral agents is the cytomegalovirus (CMV). In the neonatal period the virus incidence goes from 0.4 to 2.5 % with a seroprevalence of 50 to 75 %; the incidence of infection in newborn with RDS is unknown. The objective was to determine the frequency of CMV infection in neonates with RDS and identify the risk factors associated with infection...
May 2015: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/25975324/timing-of-optimal-surgical-intervention-for-neonates-with-necrotizing-enterocolitis
#18
Anthony J Munaco, Michelle A Veenstra, Evan Brownie, Logan A Danielson, Kartheek B Nagappala, Michael D Klein
Up to half of all patients with necrotizing enterocolitis require acute surgical treatment. Determining when to operate on these patients can be challenging. Utilizing a combination of clinical and metabolic indicators, we sought to identify the optimal timing of surgical intervention. A retrospective chart review was conducted on patients with necrotizing enterocolitis from 2001 to 2010. Previously validated clinical (abdominal erythema, palpable abdominal mass, hypotension), radiographic (pneumoperitoneum, portal venous gas, fixed bowel loop, severe pneumatosis intestinalis), and laboratory (acidosis, bacteremia, hyponatremia, bandemia, neutropenia, thrombocytopenia) indicators were assessed for the ability to predict the need for acute surgical intervention as a simple indicator score, based on the sum of the indicators listed above...
May 2015: American Surgeon
https://www.readbyqxmd.com/read/25810932/methimazole-associated-neutropenia-in-a-preterm-neonate-treated-for-hyperthyroidism
#19
Dimitrios Angelis, Rita Ann Kubicky, Alan B Zubrow
Maternal Graves' disease is relatively uncommon with an estimated incidence of 0.4%-1% of all pregnancies, but only 1-5% of newborns delivered to mothers with Graves' disease develop overt clinical signs and symptoms of hyperthyroidism. Here, we describe a case of a 1380-gram female neonate who was born at 30-week gestation to a mother with Graves' disease. Our patient presented with hyperthyroidism followed by transient hypothyroidism requiring treatment with levothyroxine. While hyperthyroid, she was treated with methimazole, iodine, and a beta-blocker...
2015: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/25738669/valganciclovir-for-symptomatic-congenital-cytomegalovirus-disease
#20
RANDOMIZED CONTROLLED TRIAL
David W Kimberlin, Penelope M Jester, Pablo J Sánchez, Amina Ahmed, Ravit Arav-Boger, Marian G Michaels, Negar Ashouri, Janet A Englund, Benjamin Estrada, Richard F Jacobs, José R Romero, Sunil K Sood, M Suzanne Whitworth, Mark J Abzug, Mary T Caserta, Sandra Fowler, Jorge Lujan-Zilbermann, Gregory A Storch, Roberta L DeBiasi, Jin-Young Han, April Palmer, Leonard B Weiner, Joseph A Bocchini, Penelope H Dennehy, Adam Finn, Paul D Griffiths, Suzanne Luck, Kathleen Gutierrez, Natasha Halasa, James Homans, Andi L Shane, Michael Sharland, Kari Simonsen, John A Vanchiere, Charles R Woods, Diane L Sabo, Inmaculada Aban, Huichien Kuo, Scott H James, Mark N Prichard, Jill Griffin, Dusty Giles, Edward P Acosta, Richard J Whitley
BACKGROUND: The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time. METHODS: We conducted a randomized, placebo-controlled trial of valganciclovir therapy in neonates with symptomatic congenital CMV disease, comparing 6 months of therapy with 6 weeks of therapy. The primary end point was the change in hearing in the better ear ("best-ear" hearing) from baseline to 6 months...
March 5, 2015: New England Journal of Medicine
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