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Eosinophilic meningitis

Céline Dard, Jean-Eudes Piloquet, Yvonne Qvarnstrom, LeAnne M Fox, Helmi M'kada, Jean-Christophe Hebert, Didier Mattera, Dorothée Harrois
Infection by the rat lungworm Angiostrongylus cantonensis represents the most common cause of infectious eosinophilic meningitis in humans, causing central nervous system (CNS) angiostrongyliasis. Most of CNS angiostrongyliasis cases were described in Asia, Pacific Basin, Australia, and some limited parts of Africa and America. CNS angiostrongyliasis has been reported in the Caribbean but never in the Lesser Antilles. The primary objectives of this study were to depict the first case of CNS angiostrongyliasis in the Lesser Antilles and investigate the environmental presence of A...
January 9, 2017: American Journal of Tropical Medicine and Hygiene
Sirilak Dusitsittipon, Charles D Criscione, Serge Morand, Chalit Komalamisra, Urusa Thaenkham
Delimitation of species is still a necessity among parasitic pathogens especially where morphological characters provide limited discernibility. Identification of cryptic lineages (independently evolving lineages that are morphologically similar) is critical as there could be lineage-specific traits that are of epidemiological importance. Angiostrongylus cantonensis is a zoonotic pathogen that can cause eosinophilic meningitis in humans. Recent reports of single marker sequence divergence hint at the potential for cryptic diversity in this lungworm...
December 8, 2016: Molecular Phylogenetics and Evolution
Kathryn Y Bray, Karen R Muñana, Kristina Meichner, Laura A White, Gabriela Seiler
A 12-year-old cat was presented for evaluation of progressive tetraparesis. Magnetic resonance imaging of the cervical spine demonstrated T2-hyperintensity, and contrast enhancement within the C4-C7 spinal cord, with marked meningeal contrast enhancement and segmental nerve root thickening. Lumbar cerebrospinal fluid contained 407 total nucleated cells/μL, with 99% eosinophils. The cat transiently improved with prednisolone, clindamycin, and ivermectin therapy, but subsequently worsened and was euthanized...
December 2016: Veterinary Clinical Pathology
Ai-Ling Chen, Xi Sun, Wei Wang, Jin-Feng Liu, Xin Zeng, Jing-Fan Qiu, Xin-Jian Liu, Yong Wang
BACKGROUND: Immunosuppression has been described as a consequence of brain injury and infection by different mechanisms. Angiostrongylus cantonensis can cause injury to the central nervous system and eosinophilic meningitis to human. Both T cell and B cell immunity play an essential role in the resistance of the infection. However, whether brain injury caused by A. cantonensis infection can lead to immunosuppression is not clear. Therefore, the present study sought to observe the alteration of immune responses in mice infected with A...
October 12, 2016: Journal of Neuroinflammation
Catherine E Foster, Erin G Nicholson, Angela C Chun, Maya Gharfeh, Sara Anvari, Filiz O Seeborg, Michael A Lopez, Judith R Campbell, Lucila Marquez, Jeffrey R Starke, Debra L Palazzi
Fever of unknown origin (FUO) in children is frequently caused by infectious diseases. Angiostrongylus cantonensis, while a primary cause of eosinophilic meningitis, is rarely a cause of FUO. We present 2 pediatric cases of FUO caused by Angiostrongylus cantonensis acquired in Houston, Texas, outside its usual geographic distribution.
December 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Rutchanee Rodpai, Pewpan M Intapan, Tongjit Thanchomnang, Oranuch Sanpool, Lakkhana Sadaow, Sakhone Laymanivong, Win Papa Aung, Issarapong Phosuk, Porntip Laummaunwai, Wanchai Maleewong
Angiostrongylus cantonensis is a zoonotic nematode parasite causing human eosinophilic meningitis (or meningoencephalitis) worldwide. A closely related species, Angiostrongylus malaysiensis, might also be a human pathogen. Larvae were obtained from land snails in Lao PDR, Cambodia, Myanmar and Thailand. We sequenced two nuclear gene regions (nuclear ribosomal ITS2 and SSU rRNA) and a portion of one mitochondrial gene (COI) from these larvae. Angiostrongylus cantonensis and A. malaysiensis were identified. This is the first report of the molecular identification of the two Angiostrongylus species in Lao PDR, Cambodia and Myanmar...
2016: PloS One
Charles Langelier, Michael J Reid, Cathra Halabi, Natalie Witek, Alejandro LaRiviere, Maulik Shah, Michael R Wilson, Peter Chin-Hong, Vanja Douglas, Kevin R Kazacos, Jennifer M Babik
After severe neurocognitive decline developed in an otherwise healthy 63-year-old man, brain magnetic resonance imaging showed eosinophilic meningoencephalitis and enhancing lesions. The patient tested positive for antibodies to Baylisascaris spp. roundworms, was treated with albendazole and dexamethasone, and showed improvement after 3 months. Baylisascariasis should be considered for all patients with eosinophilic meningitis.
2016: Emerging Infectious Diseases
Apichat Vitta, Paron Dekumyoy, Chalit Komalamisra, Thareerat Kalambaheti, Timothy P Yoshino
Angistrongylus cantonensis is a zoonotic nematode parasite and causative agent of human angiostrongyliasis, which clinically presents as eosinophilic meningitis or meningoencephalitis. Diagnosis of the disease is problematic since parasitologic findings are infrequent, and infection determinations must be based on the clinical symptoms and serological tests with limited specificities and sensitivities. The aim of the present study was to identify and generate a novel recombinant protein from A. cantonensis and evaluate its efficacy in the diagnosis of human angiostrongyliasis when incorporated into a Western blot serodiagnostic system...
July 13, 2016: Parasitology Research
Vitta Apichat, Srisongcram Narongrit, Thiproaj Jittranuch, Wongma Anucha, Polsut Wilaiwan, Fukruksa Chamaiporn, Yimthin Thatcha, Mangkit Bandid, Thanwisai Aunchalee, Dekumyoy Paron
Angiostrongylus cantonensis is an emerging infectious agent causing eosinophilic meningitis or meningoencephalitis in humans with clinical manifestation of severe headache. Molecular genetic studies on classification and phylogeny of A. cantonensis in Thailand are limited. This study surveyed A. cantonensis larvae prevalence in natural intermediate hosts across Thailand and analyzed their phylogenetic relationships. A total of 14,032 freshwater and land snails were collected from 19 provinces of Thailand. None of Filopaludina sp, Pomacea sp, and Cyclophorus sp were infected with Angiostrongylus larvae, whereas Achatina fulica, Cryptozona siamensis, and Megaustenia siamensis collected from Kalasin, Kamphaeng Phet, Phetchabun, Phitsanulok, and Tak Provinces were infected, with C...
May 2016: Southeast Asian Journal of Tropical Medicine and Public Health
Mamdouh M M El-Bahnasawy, Mohammad Reda El Feky, Ayman T A Morsy, Mousa A M Ismail, Tosson A Morsy
Meningoencephalitis is an acute inflammation of the brain and spinal cord & their covering protective membranes. Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency. The commonest symptoms of meningitis are headache and neck stiffness associated with fever, confusion or altered consciousness, vomiting, and an inability to tolerate light (photophobia) or loud noises (phonophobia). Children often exhibit only nonspecific symptoms, such as irritability and drowsiness...
April 2016: Journal of the Egyptian Society of Parasitology
C A Waugh, J F Lindo, J Lorenzo-Morales, R D Robinson
The infection status of angiostrongylosis in Jamaica was assessed in wild rats and molluscs in the 5 years following the major outbreak of eosinophilic meningitis (EM) in 2000. Parasitological analyses of 297 Rattus rattus and 140 Rattus norvegicus, and 777 terrestrial molluscs from all 14 Parishes on the island revealed Angiostrongylus cantonensis in 32·0% of the rats and in 12·5% of the molluscs. Multivariate analyses confirmed that A. cantonensis occurred significantly more frequently in R. rattus (Odds Ratio [OR] = 1·76), while mean infection intensity in R...
August 2016: Parasitology
Kiyotaka Saito, Kouji Yamasaki, Kiyotaka Yokogami, Asya Ivanova, Go Takeishi, Yuichiro Sato, Hideo Takeshima
Although carmustine (Gliadel) wafers improve local tumor control and extend the overall survival in patients with malignant glioma, adverse effects have been documented. The authors report the first case of eosinophilic meningitis triggered by the placement of Gliadel wafers. A 61-year-old man with a history of alimentary allergy and glioblastoma in the right frontal lobe underwent resection followed by the implantation of Gliadel wafers. Three weeks later he suffered the sudden onset of headache, vomiting, and progressive consciousness disturbance...
June 10, 2016: Journal of Neurosurgery
Hasan Al-Hakami, Abdurhman S Al-Arfaj, Mohammed Al-Sohaibani, Najma A Khalil
Granulomatosis with polyangiitis (GPA) formerly called Wegener's granulomatosis is a chronic necrotizing granulomatous inflammatory disease with systemic vasculitis involving the upper and lower respiratory tract, and kidneys. The typical histopathology is that of necrotizing granulomatous inflammation with palisading histiocytes, neutrophils, and lymphocytes. We report a case of a 57-year-old lady presenting with left eye swelling, left ear pain and discharge, but with no pulmonary or renal symptoms. Investigations revealed positive cytoplasmic antineutrophil cytoplasmic antibodies  and proteinase 3 antibodies...
June 2016: Saudi Medical Journal
Mahdis Aghazadeh, Marina C Harvie, Helen C Owen, Carolina Veríssimo, Kieran V Aland, Simon A Reid, Rebecca J Traub, Donald P McMANUS, James S McCARTHY, Malcolm K Jones
This study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with Angiostrongylus mackerrasae and the closely related species A. cantonensis. Time course analyses showed that A. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. Both A. mackerrasae and the genetically similar A. cantonensis caused eosinophilic meningitis in mice at two time points of 14 and 21 days post infection (dpi)...
September 2016: Parasitology
Feng Wu, Jie Wei, Zhen Liu, Xin Zeng, Zilong Yu, Zhiyue Lv, Xi Sun, Zhongdao Wu
Angiostrongyliasis caused by Angiostrongylus cantonensis (A. cantonensis) is an emerging food-borne parasitic disease, which refers basically to eosinophilic meningitis. Chitinase-like protein 3 (Chil3), a member of chitinase-like protein family which has chemotactic activity for eosinophils, is reported to be highly upregulated in brain of mouse infected with A. cantonensis. The mechanisms of high expression of Chil3 and the association between A. cantonensis and Chil3 are rarely reported. In order to understand the mechanism of high expression of Chil3 in A...
October 2016: Parasitology Research
Joel Barratt, Douglas Chan, Indy Sandaradura, Richard Malik, Derek Spielman, Rogan Lee, Deborah Marriott, John Harkness, John Ellis, Damien Stark
Angiostrongylus cantonensis is a metastrongyloid nematode found widely in the Asia-Pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. Rattus rats are definitive hosts of A. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs. Humans are dead-end hosts that usually become infected upon ingestion of infected molluscs. A presumptive diagnosis is often made based on clinical features, a history of mollusc consumption, eosinophilic pleocytosis in cerebral spinal fluid, and advanced imaging such as computed tomography...
August 2016: Parasitology
Ze-Xun Mo, Jin-Qiang Guo, Dan She, Xin Zhang, Santhosh Puthiyakunnon, Xiao-Guang Chen, Zhong-Dao Wu, Jyh-Wei Shin, Li-Wang Cui, Hua Li
BACKGROUND: The parasitic nematode Angiostrongylus cantonensis is the primary pathogen causing eosinophilic meningitis and meningoencephalitis in nonpermissive hosts. The larval parasites are eliminated by the host's immune responses in the central nervous system (CNS) through infiltration of eosinophils and lymphocytes. This study aimed to determine primary alterations of microRNA (miRNA) during A. cantonensis infection in mice. METHODS: miRNA array was used to analyze the expression of miRNA in uninfected and A...
March 16, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Loïc Epelboin, Renaud Blondé, Abdourahim Chamouine, Alexandra Chrisment, Laure Diancourt, Nicolas Villemant, Agnès Atale, Claire Cadix, Valérie Caro, Denis Malvy, Louis Collet
INTRODUCTION: Human angiostrongyliasis (HA) is a neurological helminthic disease caused by the lung worm Angiostrongylus cantonensis. It is suspected in the combination of travel or a residence in an endemic area and eosinophilic meningitis. In Mayotte, an island in the Indian Ocean, cases are rare but regular. The main objective of our study was to describe the epidemiological and diagnosis clues of HA in Mayotte. The secondary objectives were to evaluate the contribution of Real-Time Polymerase Chain Reaction (RT- PCR) for the diagnosis of HA, delineate the characteristics of the local transmission and ascertain the presence of A...
May 2016: PLoS Neglected Tropical Diseases
Hao-Hung Tsai, Ling-Yuh Shyu, Seong Yong Lim, Yeu-Sheng Tyan, Jun-Cheng Weng
Angiostrongylus cantonensis has become a global source of infection in recent years, and the differential diagnosis and timely follow-up are crucial in the management of the infection. Magnetic resonance imaging (MRI) has been suggested as a non-invasive technique in characterizing and localizing lesions during the parasitic infections in the brain. Non-invasive diffusion tensor imaging (DTI) can be used to distinguish microscopic cerebral structures but cannot resolve the more complicated neural structure...
May 2016: Acta Tropica
Hiba Hadid, Paul Nona, Muhammad Usman, David Paje
A 51-year-old African-American man with underlying pulmonary, hepatic and splenic sarcoidosis, reported a 3-day history of headache, neck stiffness and photophobia. He was not using medication for chronic sarcoidosis. Physical examination was significant for nuchal rigidity. Lumbar puncture revealed marked eosinophilia in the cerebrospinal fluid, which, on further analysis, demonstrated a positive cryptococcal antigen. HIV antibody and PCR tests were negative. Bronchoscopy and fungal blood cultures were also negative...
2015: BMJ Case Reports
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