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https://www.readbyqxmd.com/read/28694301/helminth-antigens-counteract-a-rapid-high-fat-diet-induced-decrease-in-adipose-tissue-eosinophils
#1
Susan M van den Berg, Andrea D van Dam, Pascal J Kusters, Linda Beckers, Myrthe den Toom, Saskia van der Velden, Jan Van den Bossche, Irma van Die, Mariëtte R Boon, Patrick C N Rensen, Esther Lutgens, Menno P de Winther
Brown adipose tissue (BAT) activation and white adipose tissue (WAT) beiging can increase energy expenditure and have the potential to reduce obesity and associated diseases. The immune system is a potential target in mediating brown and beige adipocyte activation. Type 2 and anti-inflammatory immune cells contribute to metabolic homeostasis within lean WAT, with a prominent role for eosinophils and interleukin (IL)-4 induced anti-inflammatory macrophages. We determined eosinophil numbers in epididymal WAT (EpAT), subcutaneous WAT (ScAT) and BAT after 1 day, 3 days or 1 week of high-fat diet (HFD) feeding in C57Bl/6 mice...
July 10, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28646347/alendronate-treatment-induces-il-1b-expression-and-apoptosis-in-glioblastoma-cell-line
#2
Paola Maura Tricarico, Angeladine Epate, Fulvio Celsi, Sergio Crovella
Alendronate (ALD), one among the nitrogen-containing bisphosphonates (NBPs), is currently used for the treatment of many pathological conditions. Unfortunately, although generally tolerated, NBPs treatment has been associated with central nervous system (CNS) adverse outcomes, such as amnesia, hallucinations and visual disturbances. So, we analyzed the effect of ALD treatment in glial cells, the main sources of cholesterol for neurons and principal cells involved in the immunological defense of the brain. We treated a glial cell line (U87-MG) with increasing doses of ALD (0...
June 23, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28497388/first-experience-with-electronic-feedback-of-the-psychosocial-assessment-tool-in-pediatric-cancer-care
#3
Sasja A Schepers, Simone M Sint Nicolaas, Heleen Maurice-Stam, Elisabeth M van Dijk-Lokkart, Esther M M van den Bergh, Nienke de Boer, Chris M Verhaak, Martha A Grootenhuis
PURPOSE: The Psychosocial Assessment Tool (PAT) is a brief family screener, identifying families at universal or elevated risk for psychosocial problems. This study aimed to determine the feasibility and usability of the electronic PAT (ePAT) in pediatric cancer care. METHODS: Eighty-six parents of newly diagnosed children with cancer (0-18 years) agreed to participate and registered at the website www.hetklikt.nu (58%). Seventy-five families completed the ePAT at approximately 1 month post-diagnosis...
May 11, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28191635/the-role-of-epicardial-adipose-tissue-in-cardiac-biology-classic-concepts-and-emerging-roles
#4
Alexios S Antonopoulos, Charalambos Antoniades
Classic concepts about the role of epicardial adipose tissue (EpAT) in heart physiology include its role in cardiac metabolism, mechanical protection of coronaries, innervation and possibly cryoprotection of the heart too. Nevertheless, recent evidence has revealed that epicardial adipose tissue regulates multiple aspects of cardiac biology including myocardial redox state, intracellular Ca(2+) cycling, the electrophysiological and contractile properties of cardiomyocytes, cardiac fibrosis as well as coronary atherosclerosis progression...
June 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28092336/construction-of-expanded-prefabricated-adipose-tissue-using-an-external-volume-expansion-device
#5
Yi Yuan, Shuifa Yang, Yangyan Yi, Jianhua Gao, Feng Lu
BACKGROUND: Multiple studies have demonstrated that mechanical forces promote the growth of adipose tissue. However, the mechanism of adipose tissue regeneration induced by mechanical forces remains unclear. METHODS: In an experiment using rats, prefabricated adipose tissue with a vessel pedicle was expanded using an external volume expansion device. The volume of fat flaps was tested at different time points. Cell proliferation and angiogenesis were analyzed using immunofluorescence...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27996218/association-of-early-physical-activity-time-with-pain-activities-of-daily-living-and-progression-of-vertebral-body-collapse-in-patients-with-vertebral-compression-fractures-an-observational-study-at-single-institution
#6
Hideki Kataoka, Tatsunori Ikemoto, Ayana Yoshimura, Mihoko Shibuya, Kyo Goto, Jyunichirou Yamashita, Kaoru Morita, Jyunya Sakamoto, Jiro Nakano, Minoru Okita
BACKGROUND: Physical activity can reduce pain and improve the ability to perform daily activities in patients with acute low back pain (LBP) due to various non-specific causes. The association between physical activity during the early phase of acute vertebral compression fractures (VCFs) and rehabilitation outcomes is unknown. AIM: To investigate the effects of early physical activity time (EPAT) on pain following acute VCFs, recovery of the ability to perform activities of daily living (ADLs), and progression of fractured vertebral body collapse...
December 19, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27888441/comparison-of-conventional-incision-and-drainage-for-pilonidal-abscess-versus-novel-endoscopic-pilonidal-abscess-treatment-epat
#7
M A Javed, H Fowler, Y Jain, S Singh, M Scott, R Rajaganeshan
No abstract text is available yet for this article.
December 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/27858291/molecular-characterization-of-a-novel-ssrna-ourmia-like-virus-from-the-rice-blast-fungus-magnaporthe-oryzae
#8
Adriana Illana, Marco Marconi, Julio Rodríguez-Romero, Ping Xu, Tamas Dalmay, Mark D Wilkinson, Maria Ángeles Ayllón, Ane Sesma
In this study we characterize a novel positive and single stranded RNA (ssRNA) mycovirus isolated from the rice field isolate of Magnaporthe oryzae Guy11. The ssRNA contains a single open reading frame (ORF) of 2,373 nucleotides in length and encodes an RNA-dependent RNA polymerase (RdRp) closely related to ourmiaviruses (plant viruses) and ourmia-like mycoviruses. Accordingly, we name this virus Magnaporthe oryzae ourmia-like virus 1 (MOLV1). Although phylogenetic analysis suggests that MOLV1 is closely related to ourmia and ourmia-like viruses, it has some features never reported before within the Ourmiavirus genus...
March 2017: Archives of Virology
https://www.readbyqxmd.com/read/27734350/measurement-of-mrna-poly-a-tail-lengths-in-drosophila-female-germ-cells-and-germ-line-stem-cells
#9
Aymeric Chartier, Willy Joly, Martine Simonelig
mRNA regulation by poly(A) tail length variations plays an important role in many developmental processes. Recent advances have shown that, in particular, deadenylation (the shortening of mRNA poly(A) tails) is essential for germ-line stem cell biology in the Drosophila ovary. Therefore, a rapid and accurate method to analyze poly(A) tail lengths of specific mRNAs in this tissue is valuable. Several methods of poly(A) test (PAT) assays have been reported to measure mRNA poly(A) tail lengths in vivo. Here, we describe two of these methods (PAT and ePAT) that we have adapted for Drosophila ovarian germ cells and germ-line stem cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27551895/endoscopic-pilonidal-abscess-treatment-a-novel-approach-for-the-treatment-of-pilonidal-abscess
#10
Y Jain, M A Javed, S Singh, S Rout, H Joshi, R Rajaganeshan
INTRODUCTION Pilonidal abscess is a common surgical emergency. Conventional treatment with incision and drainage is associated with significant postoperative morbidity. We report our initial experience of using minimally invasive endoscopic technique for the treatment of pilonidal abscesses, referred to as endoscopic pilonidal abscess treatment (EPAT). MATERIALS AND METHODS A prospective database of all patients undergoing EPAT between January 2015 and March 2016 at Whiston Hospital was maintained. Data regarding patient demographics, peroperative variables and postoperative follow-up were recorded...
February 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27490291/durability-of-expanded-physician-assistant-training-positions-following-the-end-of-health-resources-and-services-administration-expansion-of-physician-assistant-training-funding
#11
Joanne Rolls, David Keahey
PURPOSE: The purpose of this study was to assess the number of Health Resources and Services Administration Expansion of Physician Assistant Training (EPAT)-funded physician assistant (PA) programs planning to maintain class size at expanded levels after grant funds expire and to report proposed financing methods. The 5-year EPAT grant expired in 2015, and the effect of this funding on creating a durable expansion of PA training seats has not yet been investigated. METHODS: The study used an anonymous, 9-question, Web-based survey sent to the program directors at each of the PA programs that received EPAT funding...
September 2016: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/27330780/successful-desensitization-therapy-involving-fluoroquinolone-for-the-treatment-of-a-solitary-tuberculoma-a-case-report-and-literature-review
#12
Hidehiro Watanabe, Tomonori Uruma, Ikuo Seita, Yushi Chikasawa, Ryota Kikuchi, Masayuki Itoh, Kazutetsu Aoshiba, Hiroyuki Nakamura, Tsuyoshi Oishi
The patient was a 31-year-old female with no previous health problems; however, during a health checkup in 2013, a nodule (2.5 cm in diameter) was identified in the S10 area of the left lung. No clinical symptoms were apparent. Positron emission tomography/computed tomography revealed an accumulation in the same region. The patient was suspected of having lung cancer, and video-assisted thoracoscopic surgery was performed. A histopathological examination of the resected specimen revealed epithelioid granulomas accompanied by caseous necrosis in the lesion...
July 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27170021/incident-hepatitis-c-virus-genotype-distribution-and-multiple-infection-in-australian-prisons
#13
Melanie R Walker, Hui Li, Suzy Teutsch, Brigid Betz-Stablein, Fabio Luciani, Andrew R Lloyd, Rowena A Bull
Hepatitis C virus (HCV) is a highly diverse pathogen that is classified into seven distinct genotypes. Simultaneous or sequential reinfection with multiple HCV genotypes is recognized in high-risk populations, such as injecting drug users (IDUs). Multiple infection is of clinical concern as different genotypes have various sensitivities to current antiviral therapies. Therefore, a better understanding of the frequency of multiple infection and of the genotypes currently being transmitted is clinically relevant...
July 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26838789/mutual-regulation-of-epicardial-adipose-tissue-and-myocardial-redox-state-by-ppar-%C3%AE-adiponectin-signalling
#14
Alexios S Antonopoulos, Marios Margaritis, Sander Verheule, Alice Recalde, Fabio Sanna, Laura Herdman, Costas Psarros, Hussein Nasrallah, Patricia Coutinho, Ioannis Akoumianakis, Alison C Brewer, Rana Sayeed, George Krasopoulos, Mario Petrou, Akansha Tarun, Dimitris Tousoulis, Ajay M Shah, Barbara Casadei, Keith M Channon, Charalambos Antoniades
RATIONALE: Adiponectin has anti-inflammatory effects in experimental models, but its role in the regulation of myocardial redox state in humans is unknown. Although adiponectin is released from epicardial adipose tissue (EpAT), it is unclear whether it exerts any paracrine effects on the human myocardium. OBJECTIVE: To explore the cross talk between EpAT-derived adiponectin and myocardial redox state in the human heart. METHODS AND RESULTS: EpAT and atrial myocardium were obtained from 306 patients undergoing coronary artery bypass grafting...
March 4, 2016: Circulation Research
https://www.readbyqxmd.com/read/26808028/early-propranolol-after-traumatic-brain-injury-is-associated-with-lower-mortality
#15
Ara Ko, Megan Y Harada, Galinos Barmparas, Gretchen M Thomsen, Rodrigo F Alban, Matthew B Bloom, Rex Chung, Nicolas Melo, Daniel R Margulies, Eric J Ley
BACKGROUND: β-Adrenergic receptor blockers (BBs) administered after trauma blunt the cascade of immune and inflammatory changes associated with injury. BBs are associated with improved outcomes after traumatic brain injury (TBI). Propranolol may be an ideal BB because of its nonselective inhibition and ability to cross the blood-brain barrier. We determined if early administration of propranolol after TBI is associated with lower mortality. METHODS: All adults (age ≥ 18 years) with moderate-to-severe TBI (head Abbreviated Injury Scale [AIS] score, 3-5) requiring intensive care unit (ICU) admission at a Level I trauma center from January 1, 2013, to May 31, 2015, were prospectively entered into a database...
April 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26188959/prospective-evaluation-of-early-propranolol-after-traumatic-brain-injury
#16
Jason S Murry, David M Hoang, Galinos Barmparas, Megan Y Harada, Marko Bukur, Matthew B Bloom, Kenji Inaba, Daniel R Margulies, Ali Salim, Eric J Ley
BACKGROUND: Although beta-adrenergic receptor blockade may improve outcomes after traumatic brain injury (TBI), its early use is not routine. We hypothesize that judicious early low-dose propranolol after TBI (EPAT) will improve outcomes without altering bradycardia or hypotensive events. METHODS: We conducted a prospective, observational study on all patients who presented with moderate-to-severe TBI from March 2010-August 2013. Ten initial patients did not receive propranolol (control)...
January 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/24686684/diffuse-photon-density-wavefront-speed-as-a-contrast-for-tomographic-imaging-of-heterogeneous-diffusive-media
#17
Julien Pichette, Simon Boucher, George Bouza Domínguez, Yves Bérubé-Lauzière
An imaging algorithm is implemented for tomographically reconstructing contrast maps of the space variant speed of diffuse photon density wavefronts (DPDWFs) propagating in biological tissue-like diffusing media. This speed serves as a novel contrast not previously exploited in the literature. The algorithm employs early photon arrival times (EPATs) extracted from a set of time domain measurements. A relationship between EPATs and the speed of DPDWFs is exploited as the forward model. The forward model and its use in an inverse problem are supported by experimental results...
April 1, 2014: Optics Letters
https://www.readbyqxmd.com/read/24599323/feasibility-of-noninvasive-diagnosis-and-treatment-planning-in-a-case-series-with-carotid-cavernous-fistula-using-high-resolution-time-resolved-mr-angiography-with-stochastic-trajectories-twist-and-extended-parallel-acquisition-technique-epat-6-at-3-t
#18
A Seeger, U Kramer, F Bischof, F Schuettauf, F Ebner, S Danz, U Ernemann, T-K Hauser
PURPOSE: The evaluation of carotid-cavernous fistulas (CCFs) and the intracranial vasculature has been predominantly carried out using conventional digital subtraction angiography (DSA). Recent developments in time-resolved magnetic resonance angiography (MRA) provide the opportunity to assess both multiple arterial and venous phases with high temporal and spatial resolution. Here, we investigated the feasibility of this technique to functionally assess CCF prior to intervention. METHODS: Six consecutive patients with clinical symptoms of a CCF were scheduled for clinically indicated MRA and underwent a protocol that comprised conventional imaging sequences and high resolution time-resolved MRA with interleaved stochastic trajectories (TWIST)...
September 2015: Clinical Neuroradiology
https://www.readbyqxmd.com/read/24526206/increased-sensitivity-and-accuracy-of-a-single-stranded-dna-splint-mediated-ligation-assay-spat-reveals-poly-a-tail-length-dynamics-of-developmentally-regulated-mrnas
#19
Ryuji Minasaki, David Rudel, Christian R Eckmann
Poly(A) tail length is a readout of an mRNA's translatability and stability, especially in developmental systems. PolyAdenylation Test (PAT) assays attempt to quickly measure the average poly(A) tail length of RNAs of experimental interest. Here we present sPAT, splint-mediated PAT, a procedure that uses a DNA splint to aid in the ligation of an RNA-tag to the poly(A) tail of an mRNA. In comparison to other PAT methodologies, including ePAT, sPAT is highly sensitive to low-abundance mRNAs, gives a more accurate profile of the poly(A) tail distribution, and requires little starting material...
2014: RNA Biology
https://www.readbyqxmd.com/read/24201038/%C3%AE-epatitis-a-and-enteric-fever-in-greece-2004-2011-a-cross-sectional-analysis
#20
Helena C Maltezou, Stavros Patrinos, Labrini Veneti, Kassiani Gkolfinopoulou, Androula Pavli, Kassiani Mellou, Theologia Sideroglou, Athina Spilioti, Theano Georgakopoulou
BACKGROUND: In Greece the number of international travellers has increased significantly the past decade. AIM: To study the impact of international travels on the epidemiology of hepatitis A and enteric fever in Greece. METHODS: We studied cases of hepatitis A and enteric fever notified through the National Surveillance System from January 1, 2004 through December 31, 2011. RESULTS: A total of 921 cases of hepatitis A and 106 cases of enteric fever were notified; of them, 88 (9...
March 2014: Travel Medicine and Infectious Disease
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