Samuel J E Lucas, William L Malein, Owen D Thomas, Kimberly M Ashdown, Carla A Rue, Kelsey E Joyce, Charles Newman, Patrick Cadigan, Brian Johnson, Stephen D Myers, Fiona A Myers, Alexander D Wright, John Delamere, Chris H E Imray, Arthur R Bradwell, Mark Edsell
OBJECTIVE: Altitude-related and exercise-related elevations in blood pressure (BP) increase the likelihood of developing pulmonary hypertension and high-altitude illness during high-altitude sojourn. This study examined the antihypertensive effect and potential exercise benefit of the angiotensin II receptor antagonist losartan when taken at altitude. METHODS: Twenty participants, paired for age and ACE genotype status, completed a double-blinded, randomised study, where participants took either losartan (100 mg/day) or placebo for 21 days prior to arrival at 5035 m (Whymper Hut, Mt Chimborazo, Ecuador)...
2021: BMJ Open Sport & Exercise Medicine