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David J Anderson

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https://www.readbyqxmd.com/read/29649935/polyurethane-nano-hydroxyapatite-composite-films-as-osteogenic-platforms
#1
Bailey K Barnes, Austin J Bow, Ganesh Kannarpady, Alexandru S Biris, David E Anderson, Madhu Dhar, Shawn E Bourdo
A wide variety of biomaterials are utilized in tissue engineering to generate living cells in vitro or to promote tissue growth in vivo. Regeneration of living tissue from biocompatible materials may make it possible to grow tissues ranging from bone to nerve cells. In bone regeneration, polymeric scaffolds can be enhanced by the addition of bioactive materials. To this end, this study designed several ratios of polyurethane (PU) and nano-hydroxyapatite (nHA) composites (PU-nHA ratios: 100/0, 90/10, 80/20, 70/30, 60/40 w/w)...
April 13, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29643510/intra-tumour-diversification-in-colorectal-cancer-at-the-single-cell-level
#2
Sophie F Roerink, Nobuo Sasaki, Henry Lee-Six, Matthew D Young, Ludmil B Alexandrov, Sam Behjati, Thomas J Mitchell, Sebastian Grossmann, Howard Lightfoot, David A Egan, Apollo Pronk, Niels Smakman, Joost van Gorp, Elizabeth Anderson, Stephen J Gamble, Chris Alder, Marc van de Wetering, Peter J Campbell, Michael R Stratton, Hans Clevers
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from three colorectal cancers as well as from adjacent normal intestinal crypts. Colorectal cancer cells showed extensive mutational diversification and carried several times more somatic mutations than normal colorectal cells...
April 11, 2018: Nature
https://www.readbyqxmd.com/read/29625057/tumor-evolution-and-drug-response-in-patient-derived-organoid-models-of-bladder-cancer
#3
Suk Hyung Lee, Wenhuo Hu, Justin T Matulay, Mark V Silva, Tomasz B Owczarek, Kwanghee Kim, Chee Wai Chua, LaMont J Barlow, Cyriac Kandoth, Alanna B Williams, Sarah K Bergren, Eugene J Pietzak, Christopher B Anderson, Mitchell C Benson, Jonathan A Coleman, Barry S Taylor, Cory Abate-Shen, James M McKiernan, Hikmat Al-Ahmadie, David B Solit, Michael M Shen
Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulates the histopathological and molecular diversity of human bladder cancer. Organoid lines can be established efficiently from patient biopsies acquired before and after disease recurrence and are interconvertible with orthotopic xenografts. Notably, organoid lines often retain parental tumor heterogeneity and exhibit a spectrum of genomic changes that are consistent with tumor evolution in culture...
April 5, 2018: Cell
https://www.readbyqxmd.com/read/29621622/outcomes-of-the-arterial-switch-operation-in-%C3%A2-2-5kg-neonates
#4
Michael Salna, Paul J Chai, David Kalfa, Yuki Nakamura, Ganga Krishnamurthy, Jan M Quaegebeur, Marc Najjar, Amee Shah, Stephanie Levasseur, Brett R Anderson, Emile A Bacha
OBJECTIVES: While low birth weight is a known risk factor for mortality in congenital heart lesions and may consequently delay surgical repair, outcomes in low weight neonates undergoing the arterial switch operation have not been well described. Our objective was to assess the safety of this procedure in infants weighing ≤2.5kg at the time of surgery. METHODS: We retrospectively analyzed outcomes for all neonates undergoing the arterial switch operation at our institution from 2005 to 2015...
April 2, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29618054/influence-of-residual-disease-following-surgical-resection-in-newly-diagnosed-glioblastoma-on-clinical-neurocognitive-and-patient-reported-outcomes
#5
William A Hall, Stephanie L Pugh, Jeffrey S Wefel, Terri S Armstrong, Mark R Gilbert, David G Brachman, Maria Werner-Wasik, Merideth M Wendland, Paul D Brown, Samuel T Chao, Kevin S Roof, H Ian Robins, Minesh P Mehta, Walter J Curran, Benjamin Movsas
BACKGROUND: The influence of subtotal resection (STR) on neurocognitive function (NCF), quality of life, and symptom burden in glioblastoma is unknown. If bevacizumab preferentially benefits patients with STR is unknown. OBJECTIVE: To examine these uncertainties. METHODS: NCF and patient reported outcomes (PRO) were prospectively collected in NRG Oncology RTOG 0525 and 0825. Changes in NCF and PRO measures from baseline to prespecified times were examined by Wilcoxon test, and mixed effects longitudinal modeling, to assess differences between patients who received STR vs gross-total resection...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29615503/genomic-analysis-of-a-pan-resistant-isolate-of-klebsiella-pneumoniae-united-states-2016
#6
Tom J B de Man, Joseph D Lutgring, David R Lonsway, Karen F Anderson, Julia A Kiehlbauch, Lei Chen, Maroya Spalding Walters, Maria Sjölund-Karlsson, J Kamile Rasheed, Alexander Kallen, Alison Laufer Halpin
Antimicrobial resistance is a threat to public health globally and leads to an estimated 23,000 deaths annually in the United States alone. Here, we report the genomic characterization of an unusual Klebsiella pneumoniae , nonsusceptible to all 26 antibiotics tested, that was isolated from a U.S. PATIENT: The isolate harbored four known beta-lactamase genes, including plasmid-mediated bla NDM-1 and bla CMY-6 , as well as chromosomal bla CTX-M-15 and bla SHV-28 , which accounted for resistance to all beta-lactams tested...
April 3, 2018: MBio
https://www.readbyqxmd.com/read/29610509/ileocecal-anastomosis-type-significantly-influences-long-term-functional-status-quality-of-life-and-healthcare-utilization-in-postoperative-crohn-s-disease-patients-independent-of-inflammation-recurrence
#7
Mahesh Gajendran, Anthony J Bauer, Bettina M Buchholz, Andrew R Watson, Ioannis E Koutroubakis, Jana G Hashash, Claudia Ramos-Rivers, Nilesh Shah, Kenneth K Lee, Ruy J Cruz, Miguel Regueiro, Brian Zuckerbraun, Marc Schwartz, Jason Swoger, Arthur Barrie, Janet Harrison, Douglas J Hartman, Javier Salgado, William M Rivers, Benjamin Click, Alyce M Anderson, Chandraprakash Umapathy, Dmitriy Babichenko, Michael A Dunn, David G Binion
OBJECTIVES: Anastomotic reconstruction following intestinal resection in Crohn's disease (CD) may employ side-to-side anastomosis (STSA; anti-peristaltic orientation) or end-to-end anastomosis (ETEA). Our aim was to determine the impact of these two anastomotic techniques on long-term clinical status in postoperative CD patients. METHODS: We performed a comparative effectiveness study of prospectively collected observational data from consented CD patients undergoing their first or second ileocolonic bowel resection and re-anastomosis between 2008 and 2012, in order to assess the association between anastomosis type and 2-year postoperative quality of life (QoL), healthcare utilization, disease clinical or endoscopic recurrence, use of medications, and need for repeat resection...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29607251/pseudotumor-from-metal-on-metal-total-hip-arthroplasty-causing-unilateral-leg-edema-case-presentation-and-literature-review
#8
REVIEW
Caleb W Grote, Paul C Cowan, David W Anderson, Kimberly J Templeton
Metal-on-metal (MoM) total hip arthroplasty (THA) can be associated with adverse metal reactions, including pseudotumors. This case report describes a 58-year-old female with an MoM THA-related pseudotumor that caused unilateral leg edema from compression of her external iliac vein. After thorough preoperative workup to rule out infection and deep vein thrombosis and consultation with a vascular surgeon, the patient underwent revision THA and excision of her pseudotumor. She had complete resolution of her swelling at 4 years after surgery...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29603730/forc-a-global-database-of-forest-carbon-stocks-and-fluxes
#9
Kristina J Anderson-Teixeira, Maria M H Wang, Jennifer C McGarvey, Valentine Herrmann, Alan J Tepley, Ben Bond-Lamberty, David S LeBauer
Forests play an influential role in the global carbon (C) cycle, storing roughly half of terrestrial C and annually exchanging with the atmosphere more than ten times the carbon dioxide (CO2 ) emitted by anthropogenic activities. Yet, scaling up from field-based measurements of forest C stocks and fluxes to understand global scale C cycling and its climate sensitivity remains an important challenge. Tens of thousands of forest C measurements have been made, but these data have yet to be integrated into a single database that makes them accessible for integrated analyses...
March 30, 2018: Ecology
https://www.readbyqxmd.com/read/29600726/aerobic-with-resistance-training-or-aerobic-training-alone-poststroke-a-secondary-analysis-from-a-randomized-clinical-trial
#10
Susan Marzolini, Dina Brooks, Paul Oh, David Jagroop, Bradley J MacIntosh, Nicole D Anderson, David Alter, Dale Corbett
BACKGROUND: Stroke is associated with muscle atrophy and weakness, mobility deficits, and cardiorespiratory deconditioning. Aerobic and resistance training (AT and RT) each have the potential to improve deficits, yet there is limited evidence on the utility of combined training. OBJECTIVE: To examine the effects of AT+RT versus AT on physiological outcomes in chronic stroke with motor impairments. METHODS: Participants (n = 73) were randomized to 6 months of AT (5 d/wk) or AT+RT (3 and 2 d/wk, respectively)...
March 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29599166/tramadol-breast-feeding-and-safety-in-the-newborn
#11
Greta M Palmer, Brian J Anderson, David K Linscott, Michael J Paech, Karel Allegaert
No abstract text is available yet for this article.
March 29, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29590547/ibrutinib-plus-venetoclax-for-the-treatment-of-mantle-cell-lymphoma
#12
COMPARATIVE STUDY
Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts
BACKGROUND: Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma. Complete response rates of 21% have been observed for each agent when administered as long-term continuous therapy. Preclinical models predict synergy in combination. METHODS: We conducted a single-group, phase 2 study of daily oral ibrutinib and venetoclax in patients, as compared with historical controls. Patients commenced ibrutinib monotherapy at a dose of 560 mg per day...
March 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29590412/screening-spirometry-in-military-personnel-correlates-poorly-with-exercise-tolerance-and-asthma-history
#13
David M F Anderson, Nicholas R Ondrasik, Frederic A Rawlins, Joshua A Lospinoso, Thomas B Zanders, Michael J Morris
BACKGROUND: Spirometry is an easy-to-perform test for evaluating pulmonary symptoms but has several limitations to include adequate test performance for valid results. Spirometry is not recommended to screen a general population for evidence of pulmonary disease unless symptoms are present or longitudinal screening is done for potential occupational exposures. METHODS: A single-spirometry examination was performed on 900 active duty Army soldiers, ages 18-35 yr, without documented respiratory disease...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29588842/factors-associated-with-the-efficacy-of-polyp-detection-during-routine-flexible-sigmoidoscopy
#14
Akash J Maliampurakal, Donald C McMillan, John H Anderson, Paul G Horgan, David Mansouri
Objective: Flexible sigmoidoscopy reduces the incidence of colonic cancer through the detection and removal of premalignant adenomas. However, the efficacy of the procedure is variable. The aim of the present study was to examine factors associated with the efficacy of detecting polyps during flexible sigmoidoscopy. Design and patients: Retrospective observational cohort study of all individuals undergoing routine flexible sigmoidoscopy in NHS Greater Glasgow and Clyde from January 2013 to January 2016...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588023/managing-soft-tissues-in-severe-lower-limb-trauma-in-an-ageing-population
#15
Timothy M Noblet, Philippa C Jackson, Patrick Foster, David Martin Taylor, Paul J Harwood, Jay D Wiper
PURPOSE: With an ageing population, the incidence of trauma in those aged over 65 years is increasing. Strategies for dealing with these patients must be developed. At present the standard management of open tibial fractures in the UK is described by the BOAST4 guidelines (from the British Orthopaedic Association and British Association of Plastic & Aesthetic Surgeons). It is not clear to what extent these are appropriate for older patients. We describe our experience of managing elderly patients presenting with open tibial fractures...
March 13, 2018: Injury
https://www.readbyqxmd.com/read/29587490/the-impact-of-social-support-and-partner-relationship-dynamics-on-engagement-in-hiv-care-and-antiretroviral-treatment-adherence-among-msm-in-latin-america
#16
Kelsey Anderson, Katie Biello, Joshua G Rosenberger, David Novak, Kenneth Mayer, Kate Carey, Matthew J Mimiaga
In Latin America (LA), HIV prevalence among MSM is estimated at thirty times greater than in the general male population. Little is known about the role of social support or disclosure status in relation to the HIV care continuum among LA MSM. Using multivariable logistic generalized estimation equations, we assessed the impact of social support satisfaction and disclosure status on engagement in HIV care, ART initiation, and ART adherence with data from an online, multinational sample of HIV infected MSM in Latin America (N = 2,350)...
March 27, 2018: AIDS Care
https://www.readbyqxmd.com/read/29572325/prevalence-causes-and-predictors-of-30-day-readmissions-following-hospitalization-with-acute-myocardial-infarction-complicated-by-cardiogenic-shock-findings-from-the-2013-2014-national-readmissions-database
#17
Ahmed N Mahmoud, Islam Y Elgendy, Mohammad K Mojadidi, Siddharth A Wayangankar, Anthony A Bavry, R David Anderson, Hani Jneid, Carl J Pepine
BACKGROUND: Prior studies have shown that survivors of acute myocardial infarction (AMI) complicated by cardiogenic shock are likely to have increased risk of readmissions in the early post-discharge period. However, the contemporary prevalence, reasons, and predictors of 30-day readmissions are not well known. METHODS AND RESULTS: Hospitalizations for a primary diagnosis of AMI complicated by cardiogenic shock, and discharged alive, were identified in the 2013 and 2014 Nationwide Readmissions Databases...
March 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29570296/micelle-formation-in-alkyl-sulphate-surfactants-using-dissipative-particle-dynamics
#18
Richard L Anderson, David J Bray, Annalaura Del Regno, Michael A Seaton, Andrea S Ferrante, Patrick B Warren
We use dissipative particle dynamics (DPD) to study micelle formation in alkyl sulphate surfactants, with alkyl chain lengths ranging six to twelve carbon atoms. We extend our recent DPD force-field [J. Chem. Phys., 2017, 147, 094503] to include a charged sulphate chemical group, and aqueous sodium ions. With this model we achieve good agreement with the experimental reported critical micelle concentrations (CMCs) and can match the trend in mean aggregation numbers versus alkyl chain length. We determine the CMC by fitting a charged pseudo-phase model to the dependence of the free surfactant on the total surfactant concentration above the CMC, and compare it with a direct operational definition of the CMC as the point at which half the surfactant is classed as micellar and half as monomers and sub-micellar aggregates...
March 23, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29559475/germline-mutations-in-lysine-specific-demethylase-1-lsd1-kdm1a-confer-susceptibility-to-multiple-myeloma
#19
Xiaomu Wei, M Nieves Calvo-Vidal, Siwei Chen, Gang Wu, Maria V Revuelta, Jian Sun, Jinghui Zhang, Michael F Walsh, Kim E Nichols, Vijai Joseph, Carrie Snyder, Celine M Vachon, James D McKay, Shu-Ping Wang, David S Jayabalan, Lauren M Jacobs, Dina Becirovic, Rosalie G Waller, Mykyta Artomov, Agnes Viale, Jayeshkumar Patel, Jude M Phillip, Selina Chen-Kiang, Karen Curtin, Mohamed Salama, Djordje Atanackovic, Ruben Niesvizky, Ola Landgren, Susan L Slager, Lucy A Godley, Jane Churpek, Judy E Garber, Kenneth C Anderson, Mark J Daly, Robert G Roeder, Charles Dumontet, Henry T Lynch, Charles G Mullighan, Nicola J Camp, Kenneth Offit, Robert J Klein, Haiyuan Yu, Leandro Cerchietti, Steven M Lipkin
Given the frequent and largely incurable occurrence of multiple myeloma (MM), identification of germline genetic mutations that predispose cells to MM may provide insight into disease etiology and the developmental mechanisms of its cell of origin, the plasma cell. Here we identified familial and early-onset MM kindreds with truncating mutations in lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic transcriptional repressor that primarily demethylates histone H3 on lysine 4 and regulates hematopoietic stem cell self-renewal...
March 20, 2018: Cancer Research
https://www.readbyqxmd.com/read/29555928/altered-dna-methylation-associated-with-a-translocation-linked-to-major-mental-illness
#20
Daniel L McCartney, Rosie M Walker, Stewart W Morris, Susan M Anderson, Barbara J Duff, Riccardo E Marioni, J Kirsty Millar, Shane E McCarthy, Niamh M Ryan, Stephen M Lawrie, Andrew R Watson, Douglas H R Blackwood, Pippa A Thomson, Andrew M McIntosh, W Richard McCombie, David J Porteous, Kathryn L Evans
Recent work has highlighted a possible role for altered epigenetic modifications, including differential DNA methylation, in susceptibility to psychiatric illness. Here, we investigate blood-based DNA methylation in a large family where a balanced translocation between chromosomes 1 and 11 shows genome-wide significant linkage to psychiatric illness. Genome-wide DNA methylation was profiled in whole-blood-derived DNA from 41 individuals using the Infinium HumanMethylation450 BeadChip (Illumina Inc., San Diego, CA)...
March 19, 2018: NPJ Schizophrenia
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