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David Anderson

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https://www.readbyqxmd.com/read/28644499/methods-for-the-detection-and-identification-of-pathogenic-bacteria-past-present-and-future
#1
Linda Váradi, Jia Lin Luo, David E Hibbs, John D Perry, Rosaleen J Anderson, Sylvain Orenga, Paul W Groundwater
In order to retard the rate of development of antibacterial resistance, the causative agent must be identified as rapidly as possible, so that directed patient treatment and/or contact precautions can be initiated. This review highlights the challenges associated with the detection and identification of pathogenic bacteria, by providing an introduction to the techniques currently used, as well as newer techniques that are in development. Focusing on the chemical basis for these techniques, the review also provides a comparison of their advantages and disadvantages...
June 23, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28643330/muc1-c-is-a-target-in-lenalidomide-resistant-multiple-myeloma
#2
Li Yin, Ashujit Tagde, Reddy Gali, Yu-Tzu Tai, Teru Hideshima, Kenneth Anderson, David Avigan, Donald Kufe
Lenalidomide (LEN) acts directly on multiple myeloma (MM) cells by inducing cereblon-mediated degradation of interferon regulatory factor 4, Ikaros (IKZF)1 and IKZF3, transcription factors that are essential for MM cell survival. The mucin 1 (MUC1) C-terminal transmembrane subunit (MUC1-C) oncoprotein is aberrantly expressed by MM cells and protects against reactive oxygen species (ROS)-mediated MM cell death. The present studies demonstrate that targeting MUC1-C with GO-203, a cell-penetrating peptide inhibitor of MUC1-C homodimerization, is more than additive with LEN in downregulating the WNT/β-catenin pathway, suppressing MYC, and inducing late apoptosis/necrosis...
June 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28642965/erratum-to-development-of-a-unifying-target-and-consensus-indicators-for-global-surgical-systems-strengthening-proposed-by-the-global-alliance-for-surgery-obstetric-trauma-and-anaesthesia-care-the-g4-alliance
#3
Adil Haider, John W Scott, Colin D Gause, Mira Meheš, Grace Hsiung, Albulena Prelvukaj, Dana Yanocha, Lauren M Baumann, Faheem Ahmed, Na'eem Ahmed, Sara Anderson, Herve Angate, Lisa Arfaa, Horacio Asbun, Tigistu Ashengo, Kisembo Asuman, Ruben Ayala, Stephen Bickler, Saul Billingsley, Peter Bird, Matthijs Botman, Marilyn Butler, Jo Buyske, Angelo Capozzi, Kathleen Casey, Charles Clayton, James Cobey, Michael Cotton, Dan Deckelbaum, Miliard Derbew, Catherine deVries, Jeanne Dillner, Max Downham, Natalie Draisin, David Echinard, Sohier Elneil, Ahmed ElSayed, Abigail Estelle, Allen Finley, Erica Frenkel, Philip K Frykman, Florin Gheorghe, Julian Gore-Booth, Richard Henker, Jaymie Henry, Orion Henry, Laura Hoemeke, David Hoffman, Iko Ibanga, Eric V Jackson, Pankaj Jani, Walter Johnson, Andrew Jones, Zeina Kassem, Asuman Kisembo, Abbey Kocan, Sanjay Krishnaswami, Robert Lane, Asad Latif, Barbara Levy, Dimitrios Linos, Peter Linz, Louis A Listwa, Declan Magee, Emmanuel Makasa, Michael L Marin, Claude Martin, Kelly McQueen, Jamie Morgan, Richard Moser, Robert Neighbor, William M Novick, Stephen Ogendo, Akinyinka Omigbodun, Bisola Onajin-Obembe, Neil Parsan, Beverly K Philip, Raymond Price, Shahnawaz Rasheed, Marjorie Ratel, Cheri Reynolds, Steven M Roser, Jackie Rowles, Lubna Samad, John Sampson, Harshadkumar Sanghvi, Marchelle L Sellers, David Sigalet, Bruce C Steffes, Erin Stieber, Mamta Swaroop, John Tarpley, Asha Varghese, Julie Varughese, Richard Wagner, Benjamin Warf, Neil Wetzig, Susan Williamson, Joshua Wood, Anne Zeidan, Lewis Zirkle, Brendan Allen, Fizan Abdullah
No abstract text is available yet for this article.
June 22, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28640655/usual-interstitial-pneumonia-can-be-detected-in-transbronchial-biopsies-using-machine-learning
#4
Daniel G Pankratz, Yoonha Choi, Urooj Imtiaz, Grażyna M Fedorowicz, Jessica D Anderson, Thomas V Colby, Jeffrey L Myers, David A Lynch, Kevin K Brown, Kevin R Flaherty, Mark P Steele, Steve D Groshong, Ganesh Raghu, Neil M Barth, P Sean Walsh, Jing Huang, Giulia C Kennedy, Fernando J Martinez
RATIONALE: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis. While UIP can be detected by high-resolution computed tomography (HRCT) of the chest, HRCT results are frequently inconclusive, and pathology from transbronchial biopsy (TBB) has poor sensitivity. Surgical lung biopsy (SLB) may be necessary for a definitive diagnosis. OBJECTIVES: To develop a genomic classifier in tissue obtained by TBB that distinguishes UIP from non-UIP, trained against central pathology as the reference standard...
June 22, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28639995/recovery-of-bone-mineral-density-following-discontinuation-of-tenofovir-based-hiv-pre-exposure-prophylaxis
#5
David V Glidden, Kathleen Mulligan, Vanessa McMahan, Peter L Anderson, Juan Guanira, Suwat Chariyalertsak, Susan P Buchbinder, Linda Gail Bekker, Mauro Schechter, Beatriz Grinsztejn, Robert M Grant
BACKGROUND: Oral tenofovir disoproxil fumarate (TDF) for HIV prevention and treatment is associated with decreases in bone mineral density (BMD). Previous reports suggest that these changes may be reversible after discontinuation of TDF. SETTING: A metabolic substudy of 498 participants in a randomized, placebo-controlled HIV prevention trial of oral co-formulated TDF with emtricitabine (TDF/FTC, Truvada®) for HIV preexposure prophylaxis (PrEP) enrolling a global sample of men who have sex with men and trans women...
June 19, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28639624/nearest-neighbour-resonating-valence-bonds-in-ybmggao4
#6
Yuesheng Li, Devashibhai Adroja, David Voneshen, Robert I Bewley, Qingming Zhang, Alexander A Tsirlin, Philipp Gegenwart
Since its proposal by Anderson, resonating valence bonds (RVB) formed by a superposition of fluctuating singlet pairs have been a paradigmatic concept in understanding quantum spin liquids. Here, we show that excitations related to singlet breaking on nearest-neighbour bonds describe the high-energy part of the excitation spectrum in YbMgGaO4, the effective spin-1/2 frustrated antiferromagnet on the triangular lattice, as originally considered by Anderson. By a thorough single-crystal inelastic neutron scattering study, we demonstrate that nearest-neighbour RVB excitations account for the bulk of the spectral weight above 0...
June 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28638364/impact-of-neuronal-membrane-damage-on-the-local-field-potential-in-a-large-scale-simulation-of-cerebral-cortex
#7
David L Boothe, Alfred B Yu, Pawel Kudela, William S Anderson, Jean M Vettel, Piotr J Franaszczuk
Within multiscale brain dynamics, the structure-function relationship between cellular changes at a lower scale and coordinated oscillations at a higher scale is not well understood. This relationship may be particularly relevant for understanding functional impairments after a mild traumatic brain injury (mTBI) when current neuroimaging methods do not reveal morphological changes to the brain common in moderate to severe TBI such as diffuse axonal injury or gray matter lesions. Here, we created a physiology-based model of cerebral cortex using a publicly released modeling framework (GEneral NEural SImulation System) to explore the possibility that performance deficits characteristic of blast-induced mTBI may reflect dysfunctional, local network activity influenced by microscale neuronal damage at the cellular level...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28637689/elevation-of-tp53-autoantibody-prior-to-ca125-in-preclinical-invasive-epithelial-ovarian-cancer
#8
Wei-Lei Yang, Aleksandra Gentry-Maharaj, Archana R Simmons, Andy Ryan, Evangelia O Fourkala, Zhen Lu, Keith A Baggerly, Yang Zhao, Karen Lu, David D L Bowtell, Ian Jacobs, Steven J Skates, Wei-Wu He, Usha Menon, Robert C Bast
Purpose: The TP53 tumor suppressor gene is mutated in >95% of high grade serous ovarian cancers. Detecting an autologous antibody response to TP53 might improve early detection. <p>Experimental design: An immunoassay was developed to measure TP53 autoantibody in sera from 378 cases of invasive epithelial ovarian cancer and in 944 age-matched healthy controls from the United States, Australia and the United Kingdom. Serial preclinical samples from cases and controls were also assayed from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)...
June 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28629638/editorial-overview-cardiovascular-and-renal-putting-the-brake-on-heart-breaks-emerging-targets-and-treatment-strategies-for-cardiovascular-and-renal-disorders
#9
EDITORIAL
David A Taylor, Robert J Theobald, Abdel A Abdel-Rahman, Ethan J Anderson
No abstract text is available yet for this article.
April 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28629428/study-protocol-evaluation-of-an-online-father-inclusive-universal-parenting-intervention-to-reduce-child-externalising-behaviours-and-improve-parenting-practices
#10
Lucy A Tully, Patrycja J Piotrowska, Daniel A J Collins, Kathleen S Mairet, David J Hawes, Eva R Kimonis, Rhoshel K Lenroot, Caroline Moul, Vicki Anderson, Paul J Frick, Mark R Dadds
BACKGROUND: Parenting interventions that focus on enhancing the quality and consistency of parenting are effective for preventing and reducing externalising problems in children. There has been a recent shift towards online delivery of parenting interventions in order to increase their reach and impact on the population prevalence of child externalising problems. Parenting interventions have low rates of father participation yet research suggests that father involvement may be critical to the success of the intervention...
June 19, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28624207/identification-of-novel-fibrosis-modifiers-by-in%C3%A2-vivo-sirna-silencing
#11
Elisabeth H Vollmann, Lizhi Cao, Aldo Amatucci, Taylor Reynolds, Stefan Hamann, Isin Dalkilic-Liddle, Thomas O Cameron, Markus Hossbach, Kevin J Kauffman, Faryal F Mir, Daniel G Anderson, Tatiana Novobrantseva, Victor Koteliansky, Tatiana Kisseleva, David Brenner, Jeremy Duffield, Linda C Burkly
Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed. We aimed to identify novel modifiers of tissue fibrosis expressed by myofibroblasts and their progenitors in their disease microenvironment through RNA silencing in vivo. We leveraged novel biology, targeting genes upregulated during liver and kidney fibrosis in this cell lineage, and employed small interfering RNA (siRNA)-formulated lipid nanoparticles technology to silence these genes in carbon-tetrachloride-induced liver fibrosis in mice...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28619815/complete-genome-sequence-of-a-legionella-longbeachae-serogroup-1-strain-isolated-from-a-patient-with-legionnaires-disease
#12
Sandy Slow, Trevor Anderson, James Miller, Siddharth Singh, David Murdoch, Patrick J Biggs
Legionella longbeachae serogroup 1, predominantly found in soil and composted plant material, causes the majority of cases of Legionnaires' disease (LD) in New Zealand. Here, we report the complete genome sequence of an L. longbeachae serogroup 1 (sg1) isolate derived from a patient hospitalized with LD in Christchurch, New Zealand.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28619620/development-of-a-solid-dosage-platform-for-the-oral-delivery-of-bilayer-vesicles
#13
Jitinder S Wilkhu, Sarah E Mcneil, David E Anderson, Marc Kirchmeier, Yvonne Perrie
Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10% mannitol and 10% dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen...
June 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28617321/evolving-identification-of-blood-cells-associated-with-clinically-isolated-syndrome-importance-of-time-since-clinical-presentation-and-diagnostic-mri
#14
Stephanie Trend, Anderson P Jones, Sian Geldenhuys, Scott N Byrne, Marzena J Fabis-Pedrini, David Nolan, David R Booth, William M Carroll, Robyn M Lucas, Allan G Kermode, Prue H Hart
It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling...
June 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28616888/firefighter-perceptions-of-cancer-risk-results-of-a-qualitative-study
#15
David A Anderson, Tyler R Harrison, Fan Yang, Jessica Wendorf Muhamad, Susan E Morgan
BACKGROUND: Recent epidemiological research on firefighters indicates an increased incidence of specific types of cancer. Intervention is needed in the fire service yet little is known about how firefighters perceive their cancer risk. METHODS: Participant observation (150 h, n = 100) and focus group (n = 17) data were collected from 15 fire stations in South Florida. Firefighters had at least 3 years of experience, ranks included drivers, captains, lieutenants, and specialty captains, with a median age of 51 years...
July 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28614553/a-model-for-military-civilian-collaboration-in-academic-surgery-beyond-trauma-care
#16
Jamie E Anderson, Elizabeth A David, Hilary B Loge, Diana L Farmer, Joseph M Galante
No abstract text is available yet for this article.
June 14, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28610179/two-new-species-of-callanthiid-fishes-of-the-genus-i-grammatonotus-i-%C3%A2-percoidei-callanthiidae-from-pohnpei-western-pacific
#17
William D Jr Anderson, G David Johnson
In late July/early August 2015, ichthyologists from the Bishop Museum collecting fishes off Pohnpei in the Caroline Islands group, western Pacific Ocean, obtained specimens of two undescribed species of Grammatonotus. One of the new species, G. xanthostigma, closely resembles the recently described G. brianne, differing most strikingly in the shape of the caudal fin. The other, G. pelipel, is distinctive in having the following combination of characters: disjunct lateral line, barred pattern of coloration (most distinctive in small individuals), and caudal fin truncate to slightly emarginate in small specimens, but with upper and lower lobes produced in largest example known...
March 13, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608405/revisiting-the-specificity-of-the-mhc-class%C3%A2-ii-transactivator-ciita-in-classical-murine-dendritic-cells-in-vivo
#18
David A Anderson, Gary E Grajales-Reyes, Ansuman T Satpathy, Carlos E Vasquez Hueichucura, Theresa L Murphy, Kenneth M Murphy
Ciita was discovered for its role in regulating transcription of major histocompatibility complex class II (MHCII) genes. Subsequently, CIITA was predicted to control many other genes based on reporter and ChIP-seq analysis but few such predictions have been verified in vivo using Ciita(-/-) mice. Testing these predictions for classical dendritic cells (cDCs) has been particularly difficult, since Ciita(-/-) mice lack MHCII expression required to identify cDCs. However, recent identification of the cDC-specific transcription factor Zbtb46 allows identification of cDCs independently of MHCII expression...
June 13, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28608328/towards-accurate-and-precise-t-1-and-extracellular-volume-mapping-in-the-myocardium-a-guide-to-current-pitfalls-and-their-solutions
#19
REVIEW
Donnie Cameron, Vassilios S Vassiliou, David M Higgins, Peter D Gatehouse
Mapping of the longitudinal relaxation time (T 1) and extracellular volume (ECV) offers a means of identifying pathological changes in myocardial tissue, including diffuse changes that may be invisible to existing T 1-weighted methods. This technique has recently shown strong clinical utility for pathologies such as Anderson-Fabry disease and amyloidosis and has generated clinical interest as a possible means of detecting small changes in diffuse fibrosis; however, scatter in T 1 and ECV estimates offers challenges for detecting these changes, and bias limits comparisons between sites and vendors...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28607946/it-s-only-a-matter-of-time-longevity-of-cocaine-induced-changes-in-dendritic-spine-density-in-the-nucleus-accumbens
#20
Ethan M Anderson, David W Self
Many reports show that repeated cocaine administration increases dendritic spine density in medium spiny neurons of the nucleus accumbens, but there is less agreement regarding the persistence of these changes. In this review we examine these discrepancies by systematically categorizing papers that measured cocaine-induced changes in accumbal spine density. We compare published reports based on withdrawal time, short versus long duration of cocaine administration, environmental pairing with cocaine, and core/shell subregion specificity...
February 2017: Current Opinion in Behavioral Sciences
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