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David Anderson

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https://www.readbyqxmd.com/read/29341831/role-of-bone-modifying-agents-in-multiple-myeloma-american-society-of-clinical-oncology-clinical-practice-guideline-update
#1
Kenneth Anderson, Nofisat Ismaila, Patrick J Flynn, Susan Halabi, Sundar Jagannath, Mohammed S Ogaily, Jim Omel, Noopur Raje, G David Roodman, Gary C Yee, Robert A Kyle
Purpose To update guideline recommendations on the role of bone-modifying agents in multiple myeloma. Methods An update panel conducted a targeted systematic literature review by searching PubMed and the Cochrane Library for randomized controlled trials, systematic reviews, meta-analyses, clinical practice guidelines, and observational studies. Results Thirty-five relevant studies were identified, and updated evidence supports the current recommendations. Recommendations For patients with active symptomatic multiple myeloma that requires systemic therapy with or without evidence of lytic destruction of bone or compression fracture of the spine from osteopenia on plain radiograph(s) or other imaging studies, intravenous administration of pamidronate 90 mg over at least 2 hours or zoledronic acid 4 mg over at least 15 minutes every 3 to 4 weeks is recommended...
January 17, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29340649/optic-nerve-regeneration-after-crush-remodels-the-injury-site-molecular-insights-from-imaging-mass-spectrometry
#2
David T Stark, David M G Anderson, Jacky M K Kwong, Nathan Heath Patterson, Kevin L Schey, Richard M Caprioli, Joseph Caprioli
Purpose: Mammalian central nervous system axons fail to regenerate after injury. Contributing factors include limited intrinsic growth capacity and an inhibitory glial environment. Inflammation-induced optic nerve regeneration (IIR) is thought to boost retinal ganglion cell (RGC) intrinsic growth capacity through progrowth gene expression, but effects on the inhibitory glial environment of the optic nerve are unexplored. To investigate progrowth molecular changes associated with reactive gliosis during IIR, we developed an imaging mass spectrometry (IMS)-based approach that identifies discriminant molecular signals in and around optic nerve crush (ONC) sites...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29334828/an-unusual-combination-of-double-inlet-left-ventricle-with-discordant-ventriculoarterial-connections-and-bilateral-arterial-ducts
#3
Safak Alpat, Adrian Crucean, Tarak Desai, Simon McGuirk, Robert H Anderson, Phil Botha, David Barron
The presence of bilaterally persistent arterial ducts is an uncommon abnormality. Here, we describe the anatomy and successful management of an unusual patient with bilateral ducts in the setting of double inlet left ventricle, discordant ventriculoarterial connections, aortic atresia, and a severely hypoplastic and serpentine aortic arch.
January 1, 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29331170/implementation-lessons-learned-from-the-benefits-of-enhanced-terminal-room-betr-disinfection-study-process-and-perceptions-of-enhanced-disinfection-with-ultraviolet-disinfection-devices
#4
Deverick J Anderson, Lauren P Knelson, Rebekah W Moehring, Sarah S Lewis, David J Weber, Luke F Chen, Patricia F Triplett, Michael Blocker, R Marty Cooney, J Conrad Schwab, Yuliya Lokhnygina, William A Rutala, Daniel J Sexton
OBJECTIVE To summarize and discuss logistic and administrative challenges we encountered during the Benefits of Enhanced Terminal Room (BETR) Disinfection Study and lessons learned that are pertinent to future utilization of ultraviolet (UV) disinfection devices in other hospitals DESIGN Multicenter cluster randomized trial SETTING AND PARTICIPANTS Nine hospitals in the southeastern United States METHODS All participating hospitals developed systems to implement 4 different strategies for terminal room disinfection...
January 14, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29330460/enhanced-skeletal-muscle-ribosome-biogenesis-yet-attenuated-mtorc1-and-ribosome-biogenesis-related-signalling-following-short-term-concurrent-versus-single-mode-resistance-training
#5
Jackson J Fyfe, David J Bishop, Jonathan D Bartlett, Erik D Hanson, Mitchell J Anderson, Andrew P Garnham, Nigel K Stepto
Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training versus RT alone. Twenty-three males underwent eight weeks of RT, either performed alone (RT group, n = 8), or combined with either high-intensity interval training (HIT+RT group, n = 8), or moderate-intensity continuous training (MICT+RT group, n = 7)...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330241/primary-care-physician-involvement-in-shared-decision-making-for-critically-ill-patients-and-family-satisfaction-with-care
#6
Kevin B Huang, Urs Weber, Jennifer Johnson, Nathanial Anderson, Andrea K Knies, Belinda Nhundu, Cynthia Bautista, Kelly Poskus, Kevin N Sheth, David Y Hwang
PURPOSE: An intensive care unit (ICU) patient's primary care physician (PCP) may be able to assist family with certain ICU shared medical decisions. We explored whether families of patients in nonopen ICUs who nevertheless report involvement of a patient's PCP in medical decision making are more satisfied with ICU shared decision making than families who do not. METHODS: Between March 2013 and December 2015, we administered the Family Satisfaction in the ICU 24 survey to family members of adult neuroscience ICU patients...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29327655/accuracy-between-optical-and-inertial-motion-capture-systems-for-assessing-trunk-speed-during-preferred-gait-and-transition-periods
#7
Martin Kokholm Fleron, Niels Christian Hauerbach Ubbesen, Francesco Battistella, David Leandro Dejtiar, Anderson Souza Oliveira
Motion capture through inertial sensors is becoming popular, but its accuracy to describe kinematics during changes in walking speed is unknown. The aim of this study was to determine the accuracy of trunk speed extracted using an inertial motion system compared to a gold standard optical motion system, during steady walking and stationary periods. Eleven participants walked on pre-established paths marked on the floor. Between each lap, a 1-second stationary transition period at the initial position was included prior to the next lap...
January 12, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29324630/perforated-meckel-diverticulum-a-rare-cause-of-acute-abdomen-in-children
#8
Saurabh Talathi, David Kelly, Scott Anderson, Yoginder Vaid, Jose Mestre
Meckel diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract and the most common cause of gastrointestinal bleeding in children. Although it usually follows the rule of 2's, exceptions to this rule are reported in the literature. Often asymptomatic, MD is commonly an incidental finding during surgical interventions. When symptomatic, the most common presentation of this condition is painless rectal bleeding. A myriad of other nonspecific symptoms are however possible, especially in adults, thus making this diagnosis difficult...
January 11, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29321637/detection-of-american-football-head-impacts-using-biomechanical-features-and-support-vector-machine-classification
#9
Lyndia C Wu, Calvin Kuo, Jesus Loza, Mehmet Kurt, Kaveh Laksari, Livia Z Yanez, Daniel Senif, Scott C Anderson, Logan E Miller, Jillian E Urban, Joel D Stitzel, David B Camarillo
Accumulation of head impacts may contribute to acute and long-term brain trauma. Wearable sensors can measure impact exposure, yet current sensors do not have validated impact detection methods for accurate exposure monitoring. Here we demonstrate a head impact detection method that can be implemented on a wearable sensor for detecting field football head impacts. Our method incorporates a support vector machine classifier that uses biomechanical features from the time domain and frequency domain, as well as model predictions of head-neck motions...
December 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29321248/early-life-maltreatment-predicts-adult-stress-response-in-a-long-lived-wild-bird
#10
Jacquelyn K Grace, David J Anderson
Persistent phenotypic changes due to early-life stressors are widely acknowledged, but their relevance for wild, free-living animals is poorly understood. We evaluated effects of two natural stressors experienced when young (maltreatment by adults and nutritional stress) on stress physiology in wild Nazca boobies (Sula granti) 6-8 years later, an exceptionally long interval for such studies. Maltreatment as a nestling, but not nutritional stress, was associated years later with depressed baseline corticosterone in females and elevated stress-induced corticosterone concentration [CORT] in males...
January 2018: Biology Letters
https://www.readbyqxmd.com/read/29320313/acute-radiologic-manifestations-of-america-s-opioid-epidemic
#11
David D B Bates, Katherine Gallagher, HeiShun Yu, Jennifer Uyeda, Akira M Murakami, Bindu N Setty, Stephan W Anderson, Mariza O Clement
The United States is in the midst of an opioid use epidemic, which has severe medical, social, and economic consequences. Addictions to and abuse of prescription and illicit opioids are increasing, and emergency department radiologists are increasingly being faced with the task of examining patients who present with opioid-related complications. These complications may be the result of direct drug toxicity or nonsterile injection of the drugs. Neurologic, musculoskeletal, cardiopulmonary, genitourinary, and gastrointestinal complications may be evident at diagnostic imaging in emergent settings...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29313954/phase-1-2-trial-of-temsirolimus-and-sorafenib-in-the-treatment-of-patients-with-recurrent-glioblastoma-north-central-cancer-treatment-group-study-alliance-n0572
#12
David Schiff, Kurt A Jaeckle, S Keith Anderson, Evanthia Galanis, Caterina Giannini, Jan C Buckner, Phillip Stella, Patrick J Flynn, Bradley J Erickson, John F Schwerkoske, Vesna Kaluza, Erin Twohy, Janet Dancey, John Wright, Jann N Sarkaria
BACKGROUND: Mitogen-activated protein kinase (MAPK) activation and mammalian target of rapamycin (mTOR)-dependent signaling are hallmarks of glioblastoma. In the current study, the authors conducted a phase 1/2 study of sorafenib (an inhibitor of Raf kinase and vascular endothelial growth factor receptor 2 [VEGFR-2]) and the mTOR inhibitor temsirolimus in patients with recurrent glioblastoma. METHODS: Patients with recurrent glioblastoma who developed disease progression after surgery or radiotherapy plus temozolomide and with ≤2 prior chemotherapy regimens were eligible...
January 3, 2018: Cancer
https://www.readbyqxmd.com/read/29311715/the-bone-marrow-niche-in-mds-and-mgus-implications-for-aml-and-mm
#13
REVIEW
Irene M Ghobrial, Alexandre Detappe, Kenneth C Anderson, David P Steensma
Several haematological malignancies, including multiple myeloma (MM) and acute myeloid leukaemia (AML), have well-defined precursor states that precede the development of overt cancer. MM is almost always preceded by monoclonal gammopathy of undetermined significance (MGUS), and at least a quarter of all patients with myelodysplastic syndromes (MDS) have disease that evolves into AML. In turn, MDS are frequently anteceded by clonal haematopoiesis of indeterminate potential (CHIP). The acquisition of additional genetic and epigenetic alterations over time clearly influences the increasingly unstable and aggressive behaviour of neoplastic haematopoietic clones; however, perturbations in the bone-marrow microenvironment are increasingly recognized to have key roles in initiating and supporting oncogenesis...
January 9, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29311093/characterization-of-the-preclinical-pharmacology-of-the-new-2-aminomethylphenol-jpc-3210-for-malaria-treatment-and-prevention
#14
Geoffrey W Birrell, Gavin D Heffernan, Guy A Schiehser, John Anderson, Arba L Ager, Pablo Morales, Donna MacKenzie, Karin van Breda, Marina Chavchich, Laura R Jacobus, G Dennis Shanks, David P Jacobus, Michael D Edstein
The new 2-aminomethylphenol JPC-3210 has potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity and high in vivo efficacy against murine malaria. Here we report on the pharmacokinetics of JPC-3210 in mice and monkeys and in vitro screening assays including the inhibition of cytochrome (CYP) P450 isozymes. In mice JPC-3210 is rapidly absorbed, has extensive tissue distribution with a brain tissue to plasma concentration ratio of about 5.4 and a lengthy plasma elimination half-life of about 4...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29305582/publisher-correction-natural-and-directed-antigenic-drift-of-the-h1-influenza-virus-hemagglutinin-stalk-domain
#15
Christopher S Anderson, Sandra Ortega, Francisco A Chaves, Amelia M Clark, Hongmei Yang, David J Topham, Marta L DeDiego
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
January 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29301076/solid-parahydrogen-infrared-matrix-isolation-and-computational-studies-of-lin-c2h4-m-complexes
#16
Laura F Pinelo, Elsbeth R Klotz, William R Wonderly, Leif Oscar Paulson, Sharon C Kettwich, Jan Kubelka, David Todd Anderson
Complexes of lithium atoms with ethylene have been identified as potential hydrogen storage materials. As a Li atom approaches an ethylene molecule two distinct low lying electronic states are established; one is the 2A1 electronic state (for C2v geometries) that is repulsive but supports a shallow van der Waals well and correlates with the Li 2s atomic state and the second is a 2B2 electronic state that correlates with the Li 2p atomic orbital and is a strongly bound charge transfer state. Only the 2B2 charge transfer state would be advantageous for hydrogen storage because the strong electric dipole created in the Li-(C2H4) complex due to charge transfer can bind molecular hydrogen through dipole-induced dipole and dipole-quadrupole electrostatic interactions...
January 4, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29300237/dedicated-afternoon-rounds-for-icu-patients-families-and-family-satisfaction-with-care
#17
Urs Weber, Jennifer Johnson, Nathanial Anderson, Andrea K Knies, Belinda Nhundu, Cynthia Bautista, Kevin B Huang, Muhammad Hamza, Jessica White, Anna Coppola, Kathleen M Akgün, David M Greer, Evie G Marcolini, Emily J Gilmore, Nils H Petersen, Nona Timario, Kelly Poskus, Kevin N Sheth, David Y Hwang
OBJECTIVE: It was hypothesized that adding dedicated afternoon rounds for patients' families to supplement standard family support would improve overall family satisfaction with care in a neuroscience ICU. DESIGN: Pre- and postimplementation (pre-I and post-I) design. SETTING: Single academic neuroscience ICU. PATIENTS: Patients in the neuroscience ICU admitted for longer than 72 hours or made comfort measures only at any point during neuroscience ICU admission...
January 3, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29299369/pretreatment-albumin-may-aid-in-patient-selection-for-intrahepatic-y-90-microsphere-transarterial-radioembolization-tare-for-malignancies-of-the-liver
#18
Kelly P Orwat, Thomas H Beckham, Samuel Lewis Cooper, Michael S Ashenafi, Michael Bret Anderson, Marcelo Guimaraes, Ricardo Yamada, David T Marshall
Background: Hepatic malignancies are common including primary malignancies and metastases. Transarterial radioembolization (TARE) is an important treatment option. We reviewed safety and efficacy of (TARE) in our patients to identify factors that may impact treatment outcomes in a heterogeneous population. Methods: All patients that received TARE at the Medical University of South Carolina from March 2006 through May of 2014 were included. Kaplan-Meier estimates on overall survival (OS) from date of first procedure are reported...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29297819/serum-chemistry-of-free-ranging-nazca-boobies-sula-granti
#19
Terri J Maness, David J Anderson
This study reports body mass and serum chemistry reference values of 121 male and 57 female Nazca boobies (Sulidae: Sula granti) from a colony on Isla Española, Galápagos Islands, Ecuador. Circulating aspartate aminotransferase, creatine kinase, lactate dehydrogenase, total protein, immunoglobulin Y, uric acid, blood urea nitrogen, triglycerides, cholesterol, and creatinine were quantified and analyzed by sex. Sex explained little variance in all examined variables except mass; females were heavier than males, as expected for sulids...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29295930/identification-of-a-ubiquitin-binding-interface-using-rosetta-and-deer
#20
Maxx H Tessmer, David M Anderson, Adam M Pickrum, Molly O Riegert, Rocco Moretti, Jens Meiler, Jimmy B Feix, Dara W Frank
ExoU is a type III-secreted cytotoxin expressing A2 phospholipase activity when injected into eukaryotic target cells by the bacterium Pseudomonas aeruginosa The enzymatic activity of ExoU is undetectable in vitro unless ubiquitin, a required cofactor, is added to the reaction. The role of ubiquitin in facilitating ExoU enzymatic activity is poorly understood but of significance for designing inhibitors to prevent tissue injury during infections with strains of P. aeruginosa producing this toxin. Most ubiquitin-binding proteins, including ExoU, demonstrate a low (micromolar) affinity for monoubiquitin (monoUb)...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
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