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https://www.readbyqxmd.com/read/29457776/free-anchored-nb2o5-graphene-networks-for-ultrafast-stable-lithium-storage
#1
Qinglin Deng, Mengjiao Li, Junyong Wang, Kai Jiang, Zhigao Hu, Junhao Chu
Orthorhombic Nb$_2$O$_5$ (T-Nb$_2$O$_5$) has structural merit but poor electrical conductivity, limiting their applications in energy storage. Although graphene is frequently adopted to effectively improve its electrochemical properties, the ordinary modified methods cannot meet the growing demands for high-performance. Here, we demonstrate that different graphene modified routes play a vital role in affecting the electrochemical performances of T-Nb$_2$O$_5$. By only manual shaking within one minute, Nb$_2$O$_5$ nano-particles can be rapidly adsorbed onto graphene, then the free-anchored T-Nb$_2$O$_5$@graphene three-dimensional networks (NG-3D) can be successfully prepared based on hydrogel method...
February 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29457126/using-predictive-evaluation-to-design-evaluate-and-improve-training-for-polio-volunteers
#2
Denise A Traicoff, Dave Basarab, Derek T Ehrhardt, Sandi Brown, Martin Celaya, Dennis Jarvis, Elizabeth H Howze
Background: Predictive Evaluation (PE) uses a four-step process to predict results then designs and evaluates a training intervention accordingly. In 2012, the Sustainable Management Development Program (SMDP) at the Centers for Disease Control and Prevention used PE to train Stop Transmission of Polio (STOP) program volunteers. Methods: Stakeholders defined specific beliefs and practices that volunteers should demonstrate. These predictions and adult learning practices were used to design a curriculum to train four cohorts...
March 2018: Pedagogy in Health Promotion
https://www.readbyqxmd.com/read/29456751/cannulated-screw-versus-kirschner-wire-fixation-for-milch-ii-lateral-condyle-fractures-in-a-paediatric-sawbone-model-a-biomechanical-comparison
#3
D Franks, J Shatrov, M Symes, D G Little, T L Cheng
Purpose: Lateral condyle fractures of the humerus are common in the paediatric population, accounting for up to 20% of elbow fractures. Traditional management involves internal fixation with Kirschner (K)-wires, however, this has been associated with complications and insufficiently rigid fixation. Recently, cannulated screws have been proposed as a more stable method of fixation. While cannulated screws have been thought to allow earlier range of movement and shorten time to union, data regarding the biomechanical performance and optimal screw placement is scarce...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456731/analysis-of-middle-and-long-term-efficacy-of-thoracoscope-assisted-segmental-resection-of-the-lung-on-non-small-cell-lung-cancer-in-the-early-stage
#4
Ning Ding, Ning Zhou, Qinglin Li, Guangming Ren, Min Zhou
We investigated the short- and long-term efficacy of thoracoscope-assisted segmental resection of lung of non-small cell lung cancer (NSCLC). We selected a total of 94 patients with lung cancer in the early stage who were admitted to The First People's Hospital of Xuzhou for treatment between March 2011 and February 2012. Patients were divided randomly into either the control group (n=47) or the observation group (n=47). In the observation group, patients received thoracoscope-assisted segmental resection of lung, while in the control group, the conventional thoracic surgery was performed for treatment...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456538/an-uncoupling-of-canonical-phenotypic-markers-and-functional-potency-of-ex-vivo-expanded-natural-killer-cells
#5
Nicole A P Lieberman, Kole DeGolier, Kristen Haberthur, Harrison Chinn, Kara W Moyes, Myriam N Bouchlaka, Kirsti L Walker, Christian M Capitini, Courtney A Crane
Recent advances in cellular therapies for patients with cancer, including checkpoint blockade and ex vivo -expanded, tumor-specific T cells, have demonstrated that targeting the immune system is a powerful approach to the elimination of tumor cells. Clinical efforts have also demonstrated limitations, however, including the potential for tumor cell antigenic drift and neoantigen formation, which promote tumor escape and recurrence, as well as rapid onset of T cell exhaustion in vivo . These findings suggest that antigen unrestricted cells, such as natural killer (NK) cells, may be beneficial for use as an alternative to or in combination with T cell based approaches...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29456158/autologous-ipsc-based-vaccines-elicit-anti-tumor-responses-in-vivo
#6
Nigel G Kooreman, Youngkyun Kim, Patricia E de Almeida, Vittavat Termglinchan, Sebastian Diecke, Ning-Yi Shao, Tzu-Tang Wei, Hyoju Yi, Devaveena Dey, Raman Nelakanti, Thomas P Brouwer, David T Paik, Idit Sagiv-Barfi, Arnold Han, Paul H A Quax, Jaap F Hamming, Ronald Levy, Mark M Davis, Joseph C Wu
Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antigens, and we show here a proof of principle for using irradiated iPSCs in autologous anti-tumor vaccines. In a prophylactic setting, iPSC vaccines prevent tumor growth in syngeneic murine breast cancer, mesothelioma, and melanoma models...
February 8, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29452585/beta-2-adrenergic-receptors-increase-treg-cell-suppression-in-an-ova-induced-allergic-asthma-mouse-model-when-mice-are-moderate-aerobically-exercised
#7
Kari J Dugger, Taylor Chrisman, Sarah L Sayner, Parker Chastain, Kacie Watson, Robert Estes
BACKGROUND: The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven allergic asthma mouse model, moderate aerobic exercise increases TREG cell function in a contact-dependent manner that leads to a significant reduction in chronic inflammation and restoration of lung function. However, the mechanism, whereby exercise increases TREG function, remains unknown and was the focus of these investigations...
February 17, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29451959/network-analysis-an-innovative-framework-for-understanding-eating-disorder-psychopathology
#8
Kathryn E Smith, Ross D Crosby, Stephen A Wonderlich, Kelsie T Forbush, Tyler B Mason, Markus Moessner
Network theory and analysis is an emerging approach in psychopathology research that has received increasing attention across fields of study. In contrast to medical models or latent variable approaches, network theory suggests that psychiatric syndromes result from systems of causal and reciprocal symptom relationships. Despite the promise of this approach to elucidate key mechanisms contributing to the development and maintenance of eating disorders (EDs), thus far, few applications of network analysis have been tested in ED samples...
February 16, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29450641/chronic-lymphocytic-leukemia-cells-acquire-regulatory-b-cell-properties-in-response-to-tlr9-and-cd40-activation
#9
Shimrit Ringelstein-Harlev, Irit Avivi, Mona Fanadka, Netanel A Horowitz, Tami Katz
Circulating chronic lymphocytic leukemia (CLL) cells share phenotypic features with certain subsets of regulatory B-cells (Bregs). The latter cells have been reported to negatively regulate immune cell responses, mostly by provision of IL-10. The purpose of the current study was to identify and delineate Breg properties of CLL cells. B-cells and T-cells were obtained from the peripheral blood of untreated CLL patients diagnosed according to the 2008 Guidelines of the International Workshop on Chronic Lymphocytic Leukemia...
February 15, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29449556/cd1d-dependent-immune-suppression-mediated-by-regulatory-b-cells-through-modulations-of-inkt-cells
#10
K Oleinika, E C Rosser, D E Matei, K Nistala, A Bosma, I Drozdov, C Mauri
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d-lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and ameliorate experimental arthritis...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29449531/car-t-cells-the-long-and-winding-road-to-solid-tumors
#11
REVIEW
Maria Michela D'Aloia, Ilaria Grazia Zizzari, Benedetto Sacchetti, Luca Pierelli, Maurizio Alimandi
Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29449515/-therapeutic-effects-of-low-dose-bevacizumab-for-the-treatment-of-recurrent-brain-metastases
#12
Etsuko Hattori, Akinori Miyakoshi, Kohichi Go, Toshiharu Aotake, Yoshiyuki Kawakami, Masato Sakamoto, Takeshi Kawauchi, Yuuki Oichi, Noritaka Sano, Makoto Hayase, Makoto Ohta, Yuki Hirose, Hiroki Toda
OBJECTIVE: Molecularly targeted therapy has been adopted to treat a number of cancers. Bevacizumab, a recombinant humanized monoclonal antibody against vascular endothelial growth factor, is a representative agent used in molecularly targeted therapeutic regimens. However, the therapeutic effect of bevacizumab for the treatment of brain metastases remains unknown. We report the clinical effects of low dose bevacizumab(≤2.5mg/kg/week)to treat recurrent brain metastases. METHODS: We retrospectively analyzed patients with brain metastases who had been treated with bevacizumab between 2012 and 2016 at our institution...
February 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29449509/predicting-reaction-performance-in-c-n-cross-coupling-using-machine-learning
#13
Derek T Ahneman, Jesús G Estrada, Shishi Lin, Spencer D Dreher, Abigail G Doyle
Machine learning methods are becoming integral to scientific inquiry in numerous disciplines. Here we demonstrate that machine learning can be used to predict the performance of a synthetic reaction in multidimensional chemical space using data obtained via high-throughput experimentation. We created scripts to compute and extract atomic, molecular, and vibrational descriptors for the components of a palladium-catalyzed Buchwald-Hartwig cross-coupling of aryl halides with 4-methylaniline in the presence of various potentially inhibitory additives...
February 15, 2018: Science
https://www.readbyqxmd.com/read/29449085/the-simultaneous-isolation-of-multiple-high-and-low-frequent-t-cell-populations-from-donor-peripheral-blood-mononuclear-cells-using-the-major-histocompatibility-complex-i-streptamer-isolation-technology
#14
Marthe C J Roex, Lois Hageman, Matthias T Heemskerk, Sabrina A J Veld, Ellis van Liempt, Michel G D Kester, Lothar Germeroth, Christian Stemberger, J H Frederik Falkenburg, Inge Jedema
BACKGROUND: Adoptive transfer of donor-derived T cells can be applied to improve immune reconstitution in immune-compromised patients after allogeneic stem cell transplantation. The separation of beneficial T cells from potentially harmful T cells can be achieved by using the major histocompatibility complex (MHC) I-Streptamer isolation technology, which has proven its feasibility for the fast and pure isolation of T-cell populations with a single specificity. We have analyzed the feasibility of the simultaneous isolation of multiple antigen-specific T-cell populations in one procedure by combining different MHC I-Streptamers...
February 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29448959/impaired-t-cell-mediated-hepatitis-in-peroxisome-proliferator-activated-receptor-alpha-ppar%C3%AE-deficient-mice
#15
Ian N Hines, Michael Kremer, Sherri M Moore, Michael D Wheeler
BACKGROUND: Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation. The purpose of this study was to determine whether PPARα plays a role in T cell-mediated hepatitis induced by Concanavalin A (ConA). METHODS: Wild type (wt) or PPARα-deficient (PPARα -/- ) mice were treated with ConA (15 mg/kg) by intravenous injection 0, 10 or 24 h prior to sacrifice and serum and tissue collection for analysis of tissue injury, cytokine response, T cell activation and characterization...
February 15, 2018: Biological Research
https://www.readbyqxmd.com/read/29448181/effect-of-beach-management-policies-on-recreational-water-quality
#16
Elizabeth A Kelly, Zhixuan Feng, Maribeth L Gidley, Christopher D Sinigalliano, Naresh Kumar, Allison G Donahue, Adrianus J H M Reniers, Helena M Solo-Gabriele
When beach water monitoring programs identify poor water quality, the causes are frequently unknown. We hypothesize that management policies play an important role in the frequency of fecal indicator bacteria (FIB) exceedances (enterococci and fecal coliform) at recreational beaches. To test this hypothesis we implemented an innovative approach utilizing large amounts of monitoring data (n > 150,000 measurements per FIB) to determine associations between the frequency of contaminant exceedances and beach management practices...
February 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29445372/robust-phenotypic-activation-of-eosinophils-during-experimental-toxocara-canis-infection
#17
Joice Margareth de Almeida Rodolpho, Luciana Camillo, Márcio Sobreira Silva Araújo, Elaine Speziali, Jordana Grazziela Coelho-Dos-Reis, Ricardo de Oliveira Correia, Débora Meira Neris, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, Fernanda de Freitas Anibal
Eosinophils are multifunctional cells that have cytotoxic proinflammatory activities and stimulate CD4 + T-cells in experimental models of allergy and parasitic infections. Eosinophils, when exposed to antigens, are activated, expressing the CD38/CD69 molecules and exhibited increased expression of major histocompatibility complex (MHC-II), CD80 and CD86, suggesting they play a role upon Toxocara canis antigen stimulation. In the present study, we evaluated the profile of eosinophils using conventional and image flow cytometry upon experimental T...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29445371/effects-of-microrna-on-regulatory-t-cells-and-implications-for-adoptive-cellular-therapy-to-ameliorate-graft-versus-host-disease
#18
REVIEW
Keli L Hippen, Michael Loschi, Jemma Nicholls, Kelli P A MacDonald, Bruce R Blazar
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29445007/highly-efficient-and-versatile-plasmid-based-gene-editing-in-primary-t-cells
#19
Mara Kornete, Romina Marone, Lukas T Jeker
Adoptive cell transfer is an important approach for basic research and emerges as an effective treatment for various diseases, including infections and blood cancers. Direct genetic manipulation of primary immune cells opens up unprecedented research opportunities and could be applied to enhance cellular therapeutic products. In this article, we report highly efficient genome engineering in primary murine T cells using a plasmid-based RNA-guided CRISPR system. We developed a straightforward approach to ablate genes in up to 90% of cells and to introduce precisely targeted single nucleotide polymorphisms in up to 25% of the transfected primary T cells...
February 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29444931/complete-remission-with-reduction-of-high-risk-clones-following-haploidentical-nk-cell-therapy-against-mds-and-aml
#20
Andreas T Björklund, Mattias Carlsten, Ebba Sohlberg, Lisa L Liu, Trevor Clancy, Mohsen Karimi, Sarah Cooley, Jeffrey S Miller, Monika Klimkowska, Marie Schaffer, Emma Watz, Kristina I Wikstrom, Pontus Blomberg, Bjorn E Wahlin, Marzia Palma, Lotta Hansson, Per Ljungman, Eva Hellström-Lindberg, Hans-Gustaf Ljunggren, Karl-Johan Malmberg
PURPOSE: To evaluate the safety, efficacy and immunobiological correlates of allogeneic NK cell-based therapy in primary chemotherapy-refractory or relapsed high-risk myelodysplastic syndrome (MDS), secondary AML (MDS/AML), and de novo AML patients. EXPERIMENTAL DESIGN: Sixteen patients received fludarabine/cyclophosphamide conditioning combined with total lymphoid irradiation followed by adoptive immunotherapy with IL-2-activated haploidentical NK cells. RESULTS: NK cell infusions were well tolerated with only transient adverse events observed in the 16 patients...
February 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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