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https://www.readbyqxmd.com/read/28927229/creation-and-evaluation-of-a-laboratory-administration-curriculum-for-pathology-residents
#1
Jeannette Guarner, Charles E Hill, Timothy Amukele
Objectives: A clinical laboratory management (CLM) curriculum that can objectively assess the Accreditation Council for Graduate Medical Education pathology systems-based practice milestones and can provide consistent resident training across institutions is needed. Methods: Faculty at Emory University created a curriculum that consists of assay verification exercises and interactive, case-based online modules. Beta testing was done at Emory University and Johns Hopkins...
September 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28927151/microrna-320-suppresses-cervical-cancer-cell-viability-migration-and-invasion-via-directly-targeting-foxm1
#2
Can Shi, Zhenyu Zhang
Cervical cancer is one of the most common types of gynecological cancer worldwide. MicroRNA-320 (miR-320) has been reported to be downregulated in a number of types of human cancer. However, the expression level and functions of miR-320 in cervical cancer remain unknown. In the present study, miR-320 was identified to be markedly downregulated in cervical cancer tissues and cell lines. For the functional studies, miR-320 mimic or miR-320 inhibitor was introduced into cervical cancer cell lines. The effects of miR-320 on cervical cancer cell viability, migration and invasion were evaluated using MTT, migration and invasion assays, respectively...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926957/combining-a-multi-agent-system-and-communication-middleware-for-smart-home-control-a-universal-control-platform-architecture
#3
Song Zheng, Qi Zhang, Rong Zheng, Bi-Qin Huang, Yi-Lin Song, Xin-Chu Chen
In recent years, the smart home field has gained wide attention for its broad application prospects. However, families using smart home systems must usually adopt various heterogeneous smart devices, including sensors and devices, which makes it more difficult to manage and control their home system. How to design a unified control platform to deal with the collaborative control problem of heterogeneous smart devices is one of the greatest challenges in the current smart home field. The main contribution of this paper is to propose a universal smart home control platform architecture (IAPhome) based on a multi-agent system and communication middleware, which shows significant adaptability and advantages in many aspects, including heterogeneous devices connectivity, collaborative control, human-computer interaction and user self-management...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28926922/potential-use-and-the-energy-conversion-efficiency-analysis-of-fermentation-effluents-from-photo-and-dark-fermentative-bio-hydrogen-production
#4
Zhiping Zhang, Yameng Li, Huan Zhang, Chao He, Quanguo Zhang
Effluent of bio-hydrogen production system also can be adopted to produce methane for further fermentation, cogeneration of hydrogen and methane will significantly improve the energy conversion efficiency. Platanus Orientalis leaves were taken as the raw material for photo- and dark-fermentation bio-hydrogen production. The resulting concentrations of acetic, butyric, and propionic acids and ethanol in the photo- and dark-fermentation effluents were 2966mg/L and 624mg/L, 422mg/L and 1624mg/L, 1365mg/L and 558mg/L, and 866mg/L and 1352mg/L, respectively...
September 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28926701/forensic-sampling-and-analysis-from-a-single-substrate-for-surface-enhanced-raman-spectroscopy-followed-by-paper-spray-mass-spectrometry
#5
Patrick W Fedick, Brandon J Bills, Nicholas E Manicke, R Graham Cooks
Sample preparation is the most common bottle-neck in the analysis and processing of forensic evidence. Time-consuming steps in many forensic tests involve complex separations such as liquid and gas chromatography or various types of extraction techniques, typically coupled with mass spectrometry (e.g. LC-MS). Ambient ionization ameliorates these slow steps by reducing or even eliminating sample preparation. While some ambient ionization techniques have been adopted by the forensic community, there is significant resistance to discarding chromatography as most forensic analyses require both an identification and a confirmation technique...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926645/alterations-in-regional-homogeneity-of-resting-state-cerebral-activity-in-patients-with-chronic-prostatitis-chronic-pelvic-pain-syndrome
#6
Yusong Lin, Yan Bai, Peng Liu, Xuejuan Yang, Wei Qin, Jianqin Gu, Degang Ding, Jie Tian, Meiyun Wang
The purpose of this study was to explore the neural mechanism in Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) using resting-state functional magnetic resonance imaging. The functional magnetic resonance imaging was performed on 31 male CP/CPPS-patients and 31 age and education matched male healthy controls on a 3-T magnetic resonance imaging unit. A two-sample t-test was adopted to reveal the regional homogeneity between the patients and healthy controls. The mean regional homogeneity values in the alerted brain regions of patients were correlated with the clinical measurements by using Pearson's correlation analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28926612/correction-efficacy-of-peer-education-for-adopting-preventive-behaviors-against-head-lice-infestation-in-female-elementary-school-students-a-randomised-controlled-trial
#7
Mahdi Moshki, Fereshteh Zamani-Alavijeh, Mehdi Mojadam
[This corrects the article DOI: 10.1371/journal.pone.0169361.].
2017: PloS One
https://www.readbyqxmd.com/read/28926539/the-immunology-of-the-allergy-epidemic-and-the-hygiene-hypothesis
#8
Bart N Lambrecht, Hamida Hammad
The immunology of the hygiene hypothesis of allergy is complex and involves the loss of cellular and humoral immunoregulatory pathways as a result of the adoption of a Western lifestyle and the disappearance of chronic infectious diseases. The influence of diet and reduced microbiome diversity now forms the foundation of scientific thinking on how the allergy epidemic occurred, although clear mechanistic insights into the process in humans are still lacking. Here we propose that barrier epithelial cells are heavily influenced by environmental factors and by microbiome-derived danger signals and metabolites, and thus act as important rheostats for immunoregulation, particularly during early postnatal development...
September 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28926023/the-political-economy-of-bovine-tuberculosis-in-great-britain
#9
R M Bennett
A brief history of bovine tuberculosis (bTB) and its control in Great Britain (GB) is presented. Numerous diverse policies to control the disease in humans, cattle and wildlife have been pursued over the last 100 years and many millions of pounds have been spent. After notable success in reducing the incidence and prevalence of bTB in cattle in GB from the 1950s to the mid-1980s, the geographical spread of the disease and the number of cattle slaughtered have increased continually since that time, with a high point of bTB incidence in 2008...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926019/dalys-dollars-and-dogs-how-best-to-analyse-the-economics-of-controlling-zoonoses
#10
A P M Shaw, J Rushton, F Roth, P R Torgerson
Decision-makers increasingly require comprehensive economic metrics summarising and comparing the benefits and costs of controlling zoonotic diseases. The impact of disease in people is conventionally quantified in non-monetary terms, usually a disability-adjusted life year (DALY), whereas the losses due to disease in animals, particularly livestock, are quantified in monetary terms. The potential for the development of a non-monetary metric for ill health in animals, based on life years lost and disability, is discussed and rejected...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926016/policy-analysis-for-delivery-of-contagious-bovine-pleuropneumonia-control-strategies-in-sub-saharan-africa
#11
J O Onono, B Wieland, A Suleiman, J Rushton
This paper presents a policy analysis for the implementation of contagious bovine pleuropneumonia (CBPP) control strategies in pastoral regions of sub-Saharan Africa, where the disease is endemic. A framework for policy analysis was adapted for this review. The framework has eight principal steps: defining the context of the policy, identifying the problem to be addressed by the policy, searching for evidence of the problem, identifying policy options, projecting policy outcomes, evaluating the potential policy options, weighing their outcomes and making the policy decision...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926011/the-economic-impact-of-peste-des-petits-ruminants-in-india
#12
D Bardhan, S Kumar, G Anandsekaran, J K Chaudhury, M Meraj, R K Singh, M R Verma, D Kumar, N Kumar P T, S Ahmed Lone, V Mishra, B S Mohanty, N Korade, U K De
Peste des petits ruminants (PPR) is an economically important livestock disease which affects a vast section of the small ruminant population in India. However, data on the incidence of PPR are limited and scant literature is available on the economic losses caused by the disease. In the present study, a structured sampling design was adopted, which covered the major agro-climatic regions of the country, to ascertain the morbidity and mortality rates of PPR. Available estimates of the economic losses in India due to various livestock diseases are based on single values of various epidemiological and economic parameters...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925994/chimeric-antigen-receptor-t-cell-therapy-assessment-and-management-of-toxicities
#13
REVIEW
Sattva S Neelapu, Sudhakar Tummala, Partow Kebriaei, William Wierda, Cristina Gutierrez, Frederick L Locke, Krishna V Komanduri, Yi Lin, Nitin Jain, Naval Daver, Jason Westin, Alison M Gulbis, Monica E Loghin, John F de Groot, Sherry Adkins, Suzanne E Davis, Katayoun Rezvani, Patrick Hwu, Elizabeth J Shpall
Immunotherapy using T cells genetically engineered to express a chimeric antigen receptor (CAR) is rapidly emerging as a promising new treatment for haematological and non-haematological malignancies. CAR-T-cell therapy can induce rapid and durable clinical responses, but is associated with unique acute toxicities, which can be severe or even fatal. Cytokine-release syndrome (CRS), the most commonly observed toxicity, can range in severity from low-grade constitutional symptoms to a high-grade syndrome associated with life-threatening multiorgan dysfunction; rarely, severe CRS can evolve into fulminant haemophagocytic lymphohistiocytosis (HLH)...
September 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28925983/structure-dependent-interfacial-properties-of-chaplin-f-from-streptomyces-coelicolor
#14
Mina Dokouhaki, Emma L Prime, Andrew Hung, Greg G Qiao, Li Day, Sally L Gras
Chaplin F (Chp F) is a secreted surface-active peptide involved in the aerial growth of Streptomyces. While Chp E demonstrates a pH-responsive surface activity, the relationship between Chp F structure, function and the effect of solution pH is unknown. Chp F peptides were found to self-assemble into amyloid fibrils at acidic pH (3.0 or the isoelectric point (pI) of 4.2), with ~99% of peptides converted into insoluble fibrils. In contrast, Chp F formed short assemblies containing a mixture of random coil and β-sheet structure at a basic pH of 10...
September 19, 2017: Biomolecules
https://www.readbyqxmd.com/read/28925981/a-new-first-break-picking-for-three-component-vsp-data-using-gesture-sensor-and-polarization-analysis
#15
Huailiang Li, Xianguo Tuo, Tong Shen, Ruili Wang, Jérémie Courtois, Minhao Yan
A new first break picking for three-component (3C) vertical seismic profiling (VSP) data is proposed to improve the estimation accuracy of first arrivals, which adopts gesture detection calibration and polarization analysis based on the eigenvalue of the covariance matrix. This study aims at addressing the problem that calibration is required for VSP data using the azimuth and dip angle of geophones, due to the direction of geophones being random when applied in a borehole, which will further lead to the first break picking possibly being unreliable...
September 19, 2017: Sensors
https://www.readbyqxmd.com/read/28925681/enhanced-coalescence-induced-droplet-jumping-on-nanostructured-superhydrophobic-surfaces-in-the-absence-of-microstructures
#16
Peng Zhang, Yota Maeda, Fengyong Lv, Yasuyuki Takata, Daniel Orejon
Superhydrophobic surfaces are receiving increasing attention due to the enhanced condensation heat transfer, self-cleaning and anti-icing properties by easing droplet self-removal. Despite the extensive research carried out in this topic, the presence or absence of microstructures on droplet adhesion during condensation has not been addressed yet. In this work we, therefore, address the condensation behavior on engineered superhydrophobic copper oxide surfaces with different structural finishes. More specifically, we investigate the coalescence-induced droplet-jumping performance on superhydrophobic surfaces with structures varying from the micro- to the nano-scale...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925677/polypeptide-composite-particle-assisted-organization-of-%C3%AF-conjugated-polymers-into-highly-crystalline-coffee-stains
#17
Cornelia Rosu, Ping-Hsun Chu, Christopher J Tassone, Katherine Park, Paul L Balding, Jung Ok Park, Mohan Srinivasarao, Elsa Reichmanis
We demonstrate that homopolypeptides covalently tethered to anisotropically shaped silica particles induce crystalline ordering of representative semiconducting polymers. Films drop-cast from chloroform dispersions of poly(γ-stearyl-l-glutamate) (PSLG) composite particles and poly(3-hexythiophene) (P3HT) led to highly ordered crystalline structures of P3HT. Hydrophobic-hydrophobic interactions between the alkyl side chains of P3HT and PSLG were the main driving force for P3HT chain ordering into the crystalline assemblies...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925554/monitoring-of-sesamia-nonagrioides-resistance-to-mon%C3%A2-810-maize-in-the-european-union-lessons-from-a-long-term-harmonized-plan
#18
Gema P Farinós, Pedro Hernández-Crespo, Félix Ortego, Pedro Castañera
BACKGROUND: MON 810 maize, which expresses the insecticidal protein Cry1Ab, is a highly effective method to control Sesamia nonagrioides (Lefèbvre), a key maize pest in Mediterranean countries. Monitoring programs to assess the potential development of resistance of target pests to Bt maize are mandatory in the European Union (EU). Here we report the results of the S. nonagrioides resistance monitoring plan implemented for MON 810 maize in the EU between 2004-2015 and reassess the different components of this long-term harmonized plan...
September 19, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28925552/in-situ-bone-tissue-engineering-with-an-endogenous-stem-cell-mobilizer-and-osteoinductive-nanofibrous-polymeric-scaffolds
#19
Jong Seung Lee, Yoonhee Jin, Hyun-Ji Park, Kisuk Yang, Min Suk Lee, Hee Seok Yang, Seung-Woo Cho
Classical bone tissue engineering involves the use of culture-expanded cells and scaffolds to produce tissue constructs for transplantation. Despite promising results, clinical adoption of these constructs has been limited due to various drawbacks, including extensive cell expansion steps, low cell survival rate upon transplantation, and the possibility of immuno-rejection. To bypass the ex vivo cell culture and transplantation process, we exploited the regenerative capacity of the host by mobilizing endogenous stem cells to the site of injury...
September 19, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28925532/the-interplay-between-regulatory-focus-and-temporal-distance-in-the-health-context
#20
Aleksandra Berezowska, Arnout R H Fischer, Hans C M van Trijp
OBJECTIVES: This study identifies how the interaction between temporal distance, regulatory focus, and framing of health outcomes affects individuals' intention to adopt a personalized nutrition service. DESIGN: A 2 (temporal distance: immediate health outcomes vs. delayed health outcomes) × 2 (regulatory focus: prevention vs. promotion) × 2 (health outcome framing: illness prevention vs. health promotion) full-factorial between-subjects design. METHODS: In two experiments with samples of 236 and 242 students, regulatory focus was manipulated by asking participants to describe which academic outcomes they want to either achieve or prevent and how they aim to do this...
September 19, 2017: British Journal of Health Psychology
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