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https://www.readbyqxmd.com/read/28212580/network-pharmacology-based-and-clinically-relevant-prediction-of-the-active-ingredients-and-potential-targets-of-chinese-herbs-in-metastatic-breast-cancer-patients
#1
Yu Mao, Jian Hao, Zi-Qi Jin, Yang-Yang Niu, Xue Yang, Dan Liu, Rui Cao, Xiong-Zhi Wu
Chinese Herbal Medicine (CHM) plays a significant role in breast cancer treatment. We conduct the study to ascertain the relative molecular targets of effective Chinese herbs in treating stage IV breast cancer.Survival benefit of CHM was verified by Kaplan-Meier method and Cox regression analysis. A bivariate correlation analysis was used to find and establish the effect of herbs in complex CHM formulas. A network pharmacological approach was adopted to explore the potential mechanisms of CHM.Patients in the CHM group had a median survival time of 55 months, which was longer than the 23 months of patients in the non-CHM group...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212329/enzyme-assisted-discovery-of-antioxidant-peptides-from-edible-marine-invertebrates-a-review
#2
REVIEW
Tsun-Thai Chai, Yew-Chye Law, Fai-Chu Wong, Se-Kwon Kim
Marine invertebrates, such as oysters, mussels, clams, scallop, jellyfishes, squids, prawns, sea cucumbers and sea squirts, are consumed as foods. These edible marine invertebrates are sources of potent bioactive peptides. The last two decades have seen a surge of interest in the discovery of antioxidant peptides from edible marine invertebrates. Enzymatic hydrolysis is an efficient strategy commonly used for releasing antioxidant peptides from food proteins. A growing number of antioxidant peptide sequences have been identified from the enzymatic hydrolysates of edible marine invertebrates...
February 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28212327/a-robust-random-forest-based-approach-for-heart-rate-monitoring-using-photoplethysmography-signal-contaminated-by-intense-motion-artifacts
#3
Yalan Ye, Wenwen He, Yunfei Cheng, Wenxia Huang, Zhilin Zhang
The estimation of heart rate (HR) based on wearable devices is of interest in fitness. Photoplethysmography (PPG) is a promising approach to estimate HR due to low cost; however, it is easily corrupted by motion artifacts (MA). In this work, a robust approach based on random forest is proposed for accurately estimating HR from the photoplethysmography signal contaminated by intense motion artifacts, consisting of two stages. Stage 1 proposes a hybrid method to effectively remove MA with a low computation complexity, where two MA removal algorithms are combined by an accurate binary decision algorithm whose aim is to decide whether or not to adopt the second MA removal algorithm...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28212121/identification-and-evaluation-of-clinically-significant-prostate-cancer-a-step-towards-personalized-diagnosis
#4
Adnan Ali, Alexander Hoyle, Esther Baena, Noel W Clarke
PURPOSE OF REVIEW: Prostate cancer (PCa) diagnostics are evolving rapidly. The quest to differentiate 'clinically significant' from 'clinically insignificant' disease has gathered momentum, leading to substantial change in traditional diagnostic approaches. Herein, we review the relevant information on currently available biomarkers and assess their ability to help physicians and patients in making a shared and personalized decision based on their individual risk of harbouring clinically significant disease...
February 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28212118/role-of-chronic-exercise-on-pelvic-floor-support-and-function
#5
Janet M Shaw, Ingrid E Nygaard
PURPOSE OF REVIEW: To summarize recent literature about the potential role of chronic exercise on pelvic floor support and function. RECENT FINDINGS: Stress urinary incontinence is common during physical activity. Scant evidence suggests a dose-response association between higher volumes of exercise and urinary incontinence. Athletes do not appear to have greater pelvic floor muscle strength or worse pelvic floor support compared to nonathletes. Pelvic floor muscle electromyographic activity increases substantially as running speeds increase...
February 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28212109/sustainable-exposure-prevention-through-innovative-detection-and-remediation-technologies-from-the-niehs-superfund-research-program
#6
Heather F Henry, William A Suk
Innovative devices and tools for exposure assessment and remediation play an integral role in preventing exposure to hazardous substances. New solutions for detecting and remediating organic, inorganic, and mixtures of contaminants can improve public health as a means of primary prevention. Using a public health prevention model, detection and remediation technologies contribute to primary prevention as tools to identify areas of high risk (e.g. contamination hotspots), to recognize hazards (bioassay tests), and to prevent exposure through contaminant cleanups...
February 17, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28212085/contextual-noise-reduction-for-domain-adaptive-near-duplicate-retrieval-on-merchandize-images
#7
Zhen-Qun Yang, Xiao-Yong Wei, Zhang Yi, Gerald Friedland
In this paper, we have proposed a novel method which utilizes the contextual relationship among visual words for reducing the Quantization errors in near-duplicate image retrieval (NDR). Instead of following the track of conventional NDR techniques which usually search new solutions by borrowing ideas from the text domain, we propose to model the problem back to image domain, which results in a more natural way of solution search. The idea of the proposed method is to construct a context graph that encapsulates the contextual relationship within an image and treat the graph as a pseudo-image, so that classical image filters can be adopted to reduce the mismapped visual words which are contextually inconsistent with others...
February 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28212084/objective-quality-assessment-of-screen-content-images-by-uncertainty-weighting
#8
Yuming Fang, Jiebin Yan, Jiaying Liu, Shiqi Wang, Qiaohong Li, Zongming Guo
In this paper, we propose a novel full-reference objective quality assessment metric for screen content images (SCIs) by structure features and uncertainty weighting (SFUW). The input SCI is first divided into textual and pictorial regions. The visual quality of textual regions is estimated based on perceptual structural similarity, where the gradient information is adopted as the structural feature. To predict the visual quality of pictorial regions in SCIs, we extract the structural features and luminance features for similarity computation between the reference and distorted pictorial patches...
February 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28212081/a-comparative-analysis-of-cmut-receiving-architectures-for-design-optimization-of-integrated-transceiver-front-ends
#9
Marco Sautto, Alessandro Stuart Savoia, Fabio Quaglia, Giosue Caliano, Andrea Mazzanti
A formal comparison between fundamental RX amplifier configurations for Capacitive Micromachined Ultrasonic Transducers (CMUT) is proposed in this paper. The impact on both RX and the pulse-echo frequency response and on the output SNR are thoroughly analysed and discussed. It is shown that the resistive-feedback amplifier yields a band-pass RX frequency response, while both open-loop voltage and capacitivefeedback amplifiers exhibit a low-pass frequency response. For a given power dissipation, it is formally proved that a capacitivefeedback amplifier provides a remarkable SNR improvement against the commonly adopted resistive feedback stage, achieved at the expense of a reduced pulse-echo center frequency, making its use convenient in low and mid-frequency ultrasound imaging applications...
February 13, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28211932/nanostructured-material-based-biofuel-cells-recent-advances-and-future-prospects
#10
REVIEW
Cui-E Zhao, Panpan Gai, Rongbin Song, Ying Chen, Jianrong Zhang, Jun-Jie Zhu
During the past decade, biofuel cells (BFCs) have emerged as an emerging technology on account of their ability to directly generate electricity from biologically renewable catalysts and fuels. Due to the boost in nanotechnology, significant advances have been accomplished in BFCs. Although it is still challenging to promote the performance of BFCs, adopting nanostructured materials for BFC construction has been extensively proposed as an effective and promising strategy to achieve high energy production. In this review, we presented the major novel nanostructured materials applied for BFCs and highlighted the breakthroughs in this field...
February 17, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28211812/recent-progress-in-alzheimer-s-disease-research-part-2-genetics-and-epidemiology
#11
Morgan Robinson, Brenda Y Lee, Francis T Hane
This is the second part of a three-part review series reviewing the most important advances in Alzheimer's disease (AD) research since 2010. This review covers the latest research on genetics and epidemiology. Epidemiological and genetic studies are revealing important insights into the etiology of, and factors that contribute to AD, as well as areas of priority for research into mechanisms and interventions. The widespread adoption of genome wide association studies has provided compelling evidence of the genetic complexity of AD with genes associated with such diverse physiological function as immunity and lipid metabolism being implicated in AD pathogenesis...
February 16, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28211745/superdense-coding-over-optical-fiber-links-with-complete-bell-state-measurements
#12
Brian P Williams, Ronald J Sadlier, Travis S Humble
Adopting quantum communication to modern networking requires transmitting quantum information through a fiber-based infrastructure. We report the first demonstration of superdense coding over optical fiber links, taking advantage of a complete Bell-state measurement enabled by time-polarization hyperentanglement, linear optics, and common single-photon detectors. We demonstrate the highest single-qubit channel capacity to date utilizing linear optics, 1.665±0.018, and we provide a full experimental implementation of a hybrid, quantum-classical communication protocol for image transfer...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211644/healthcare-professionals-and-pharmacovigilance-of-pediatric-adverse-drug-reactions-a-5-year-analysis-of-adverse-events-reporting-system-database-of-the-food-and-drug-administration
#13
Caterina Bigi, Marco Tuccori, Guido Bocci
BACKGROUND: To analyze the Adverse Events Reporting System (AERS) database of the Food and Drug Administration (FDA), investigating the characteristics of pediatric adverse drug reactions (ADRs) and describing the effective participation of healthcare professionals in the reporting activity. METHODS: Reports of ADRs were obtained from the FDA website. Only ADRs in pediatric subjects (divided by age, by country and by professional category) were included into the analysis...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28211226/supramolecularly-engineered-amphiphilic-macromolecules-molecular-interaction-overrules-packing-parameters
#14
Prithankar Pramanik, Debes Ray, Vinod K Aswal, Suhrit Ghosh
We report molecular interaction-driven self-assembly of supramolecularly engineered amphiphilic macromolecules (SEAM) containing a single supramolecular structure-directing unit (SSDU) consisting of an H-bonding group connected to a naphthalene diimide chromophore. Two such SEAMs, P1-50 and P2-50, having the identical chemical structure and hydrophobic/hydrophilic balance, exhibit distinct self-assembled structures (polymersome and cylindrical micelle, respectively) due to a difference in the H-bonding group (hydrazide or amide, respectively) of the single SSDU...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28211211/circulating-fibrocyte-mobilization-in-negative-pressure-wound-therapy
#15
Dezhi Chen, Yong Zhao, Zonghuan Li, Kangquan Shou, Xun Zheng, Pengcheng Li, Baiwen Qi, Aixi Yu
Non-healing diabetic wounds are difficult to treat. They also create heavy financial burdens for both patients and society. Negative pressure wound therapy (NPWT) has been adopted to treat intractable wounds and has proved to be effective. However, the mechanisms that underlie the effects of this treatment are not entirely understood. Circulating fibrocytes are unique haematopoietic-derived stem cells that have been reported to play a pivotal role in wound healing. Here, we have investigated the effect of NPWT on fibrocyte mobilization and the role of fibrocyte mobilization in the healing of diabetic wounds during NPWT...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28211183/a-comparison-of-the-self-reported-dry-eye-practices-of-new-zealand-optometrists-and-ophthalmologists
#16
Ally L Xue, Laura E Downie, Susan E Ormonde, Jennifer P Craig
PURPOSE: The aim of this cross-sectional survey was to evaluate the self-reported clinical practices of New Zealand optometrists and ophthalmologists with respect to the diagnosis and management of dry eye disease. It also sought to compare these behaviours with the current research evidence base. METHODS: An anonymous survey was distributed electronically to New Zealand eye care clinicians (optometrists n = 614, ophthalmologists n = 113) to determine practitioner interest in dry eye disease, practice experience, practice modality, preferred diagnostic and management strategies, and information used to guide patient care...
March 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28210965/techniques-of-single-stage-laparoscopic-conversion-of-roux-en-y-gastric-bypass-to-single-anastomosis-bilio-pancreatic-diversion-with-duodenal-switch
#17
Muhammad A Jawad, Lars Nelson, Rena C Moon, Andre F Teixeira
BACKGROUND: Conversion of Roux-en-Y gastric bypass (RYGB) to single anastomosis duodenal switch can be a complicated and time-consuming operation for surgeons. PURPOSE: The purpose of this article is to present our technique of single-step laparoscopic conversion of RYGB to single anastomosis duodenal switch bilio-pancreatic diversion and vertical sleeve gastrectomy, creating a 250-cm common channel. MATERIAL AND METHODS: A laparoscopic technique was utilized in the conversion...
February 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28210964/exploring-partners-experiences-in-living-with-patients-who-undergo-bariatric-surgery
#18
Anna Wallwork, Lynn Tremblay, Monica Chi, Sanjeev Sockalingam
BACKGROUND: Bariatric surgery is effective in assisting persons with severe obesity in achieving significant weight loss and improved health; however, success depends on one's lifelong commitment to lifestyle modifications post-operatively. Life partners can be essential to the success of bariatric patients as they can serve as a primary resource to patients and healthcare teams. This study aimed to explore bariatric patients' partner's experiences in order to help inform clinical practice in bariatric care to better address patient and partner needs...
February 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28210618/an-optimized-procedure-for-the-site-directed-labeling-of-ngf-and-prongf-for-imaging-purposes
#19
Pierluigi Di Matteo, Mariantonietta Calvello, Stefano Luin, Laura Marchetti, Antonino Cattaneo
Neurotrophins are growth factors of fundamental importance for the development, survival and maintenance of different neuronal and non-neuronal populations. Over the years, the use of labeled neurotrophins has helped in the study of their biological functions, leading to a better understanding of the processes that regulate their transport, traffic, and signaling. However, the diverse and heterogeneous neurotrophin labeling strategies adopted so far have often led to poorly reproducible protocols and sometimes conflicting conclusions...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28210367/academic-primer-series-eight-key-papers-about-education-theory
#20
Michael Gottlieb, Megan Boysen-Osborn, Teresa M Chan, Sara M Krzyzaniak, Nicolas Pineda, Jordan Spector, Jonathan Sherbino
INTRODUCTION: Many teachers adopt instructional methods based on assumptions of best practices without attention to or knowledge of supporting education theory. Familiarity with a variety of theories informs education that is efficient, strategic, and evidence-based. As part of the Academic Life in Emergency Medicine Faculty Incubator Program, a list of key education theories for junior faculty was developed. METHODS: A list of key papers on theories relevant to medical education was generated using an expert panel, a virtual community of practice synthetic discussion, and a social media call for resources...
February 2017: Western Journal of Emergency Medicine
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