keyword
MENU ▼
Read by QxMD icon Read
search

Adoptive

keyword
https://www.readbyqxmd.com/read/28454401/safety-and-effectiveness-of-localized-lung-resection-combined-with-neoadjuvant-chemotherapy-in-the-treatment-of-stage-i-ii-non-small-cell-lung-cancer
#1
Bing Zhu, Jianru Yang, Pei Zhang, Lin Shen, Xiaolong Li, Jing Li
This study was conducted to evaluate the safety and effectiveness of localized lung resection combined with neoadjuvant chemotherapy in the treatment of stage I-II non-small cell lung cancer (NSCLC). A total of 88 patients, who were admitted to our hospital for first diagnosis and treatment, were selected. The patients were divided into control group (n=40 cases) and observation group (n=48 cases) according to the last digit of the admission number. The control group was treated with minimally invasive localized lung resection by thoracoscope...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454356/harnessing-antitumor-immunity-employment-of-tumor-recall-antigens-to-optimize-the-inflammatory-response-to-cancer
#2
Kimberly A Silverio, Shyam A Patel
The advent of immunotherapy for cancer has contributed to the era of personalized medicine for cancer. The various immunotherapy-based treatments that have been explored thus far include monoclonal antibody therapy, tumor vaccines, immune checkpoint blockade and adoptive T cell transfer, among others. The groundwork for all these immunotherapeutic modalities rests within the tumor microenvironment, specifically the immune factors that influence the tumor-drug interface. Prior to therapeutic design, the tumor microenvironmental interactions and the current barriers to successful treatment must first be understood...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454021/reactive-mineral-removal-relative-to-soil-organic-matter-heterogeneity-and-implications-for-organic-contaminant-sorption
#3
Fangfang Li, Bo Pan, Ni Liang, Zhaofeng Chang, Yuwei Zhou, Lin Wang, Hao Li, Baoshan Xing
Soil organic matter (SOM) is generally treated as a static compartment of soil in pollutant fate studies. However, SOM might be altered or fractionated in soil systems, and the details of SOM property/composition changes when coupled with contaminant behavior are unknown. In this study, a mild acid treatment was adopted to remove reactive minerals and partially remove SOM components. After acid treatment, biomarker signatures showed that lignin-derived phenols were released and black carbon (as suggested by benzene-polycarboxylic acids) and lipids were enriched...
April 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28453986/facilitating-smallholder-tree-farming-in-fragmented-tropical-landscapes-challenges-and-potentials-for-sustainable-land-management
#4
Syed Ajijur Rahman, Terry Sunderland, James M Roshetko, John Robert Healey
Under changing land use in tropical Asia, there is evidence of forest product diversification through implementation of tree-based farming by smallholders. This paper assesses in two locations, West Java, Indonesia and eastern Bangladesh, current land use conditions from the perspective of smallholder farmers, the factors that facilitate their adoption of tree farming, and the potential of landscape-scale approaches to foster sustainable land management. Data were collected through rapid rural appraisals, focus group discussions, field observations, semi-structured interviews of farm households and key informant interviews of state agricultural officers...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28453867/syndecan-1-regulates-dendritic-cell-migration-in-cutaneous-hypersensitivity-to-haptens
#5
Marco Averbeck, Stephanie Kuhn, Johannes Bühligen, Martin Götte, Jan C Simon, Tobias Polte
In human dendritic cells (DC), we previously demonstrated in vitro that syndecan-1 (SDC1) is downregulated during maturation correlating with enhanced motility. We investigated the effects of SDC1 on DC migration in vivo during TNCB(2,4,6-trinitro-1-chlorobenzene)-induced cutaneous hypersensitivity reaction (CHS) in mice. We show that DC in SDC1-deficient mice migrated faster and at a higher rate to lymph nodes draining the hapten-painted skin. Adoptive transfer of SDC1-deficient hapten- and fluorochrome-labelled DC into wild type (WT) mice led to increased and faster migration of DC to paracortical lymph nodes, and to a stronger CHS compared to WT DC...
April 28, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28453854/the-dynamics-of-the-monomeric-restriction-endonuclease-bcni-during-its-interaction-with-dna
#6
Georgij Kostiuk, Jasmina Dikic, Friedrich W Schwarz, Giedrius Sasnauskas, Ralf Seidel, Virginijus Siksnys
Endonucleases that generate DNA double strand breaks often employ two independent subunits such that the active site from each subunit cuts either DNA strand. Restriction enzyme BcnI is a remarkable exception. It binds to the 5΄-CC/SGG-3΄ (where S = C or G, '/' designates the cleavage position) target as a monomer forming an asymmetric complex, where a single catalytic center approaches the scissile phosphodiester bond in one of DNA strands. Bulk kinetic measurements have previously shown that the same BcnI molecule cuts both DNA strands at the target site without dissociation from the DNA...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453715/the-inequity-of-inpatient-services-in-rural-areas-and-the-new-type-rural-cooperative-medical-system-nrcms-in-china-repeated-cross-sectional-analysis
#7
Bingbing Pan, Samuel D Towne, Yuxing Chen, ZhaoKang Yuan
Objective : The main aim of the New-type Rural Cooperative Medical System (NRCMS) put into effect in 2003 was to reduce financial barriers in accessing health care services among vulnerable populations. The aim of this study was to assess the association between NRCMS and income related inequality in hospital utilization among rural inhabitants in Jiangxi Province, China. Methods : A multistage stratified random cluster sampling method was adopted to select 1838, 1879, and 1890 households as participants in 2003/2004, 2008 and 2014, respectively...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453688/edlib-a-c-c%C3%A2-library-for-fast-exact-sequence-alignment-using-edit-distance
#8
Martin Šošic, Mile Šikic
Summary: We present Edlib, an open-source C/C ++ library for exact pairwise sequence alignment using edit distance. We compare Edlib to other libraries and show that it is the fastest while not lacking in functionality and can also easily handle very large sequences. Being easy to use, flexible, fast and low on memory usage, we expect it to be easily adopted as a building block for future bioinformatics tools. Availability and Implementation: Source code, installation instructions and test data are freely available for download at https://github...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453681/sphinx-merging-knowledge-based-and-ab-initio-approaches-to-improve-protein-loop-prediction
#9
Claire Marks, Jaroslaw Nowak, Stefan Klostermann, Guy Georges, James Dunbar, Jiye Shi, Sebastian Kelm, Charlotte M Deane
Motivation: Loops are often vital for protein function, however, their irregular structures make them difficult to model accurately. Current loop modelling algorithms can mostly be divided into two categories: knowledge-based, where databases of fragments are searched to find suitable conformations and ab initio, where conformations are generated computationally. Existing knowledge-based methods only use fragments that are the same length as the target, even though loops of slightly different lengths may adopt similar conformations...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453526/with-whom-do-you-feel-most-intimate-exploring-the-quality-of-facebook-friendships-in-relation-to-similarities-and-interaction-behaviors
#10
Jieun Wee, Joonhwan Lee
It is widely accepted that people tend to associate more and feel closer to those who share similar attributes with themselves. Most of the research on the phenomenon has been carried out in face-to-face contexts. However, it is necessary to study the phenomenon in computer-mediated contexts as well. Exploring Facebook is important in that friendships within the network indicate a broader spectrum of friends, ranging from complete strangers to confiding relations. Also, since diverse communication methods are available on Facebook, which method a user adopts to interact with a "friend" could influence the quality of the relationship, i...
2017: PloS One
https://www.readbyqxmd.com/read/28453508/viable-options-for-fertility-preservation-in-breast-cancer-patients-a-focus-on-latin-america
#11
Matteo Lambertini, Oranite Goldrat, Regina Barragan-Carrillo, Giulia Viglietti, Isabelle Demeestere, Cynthia Villarreal-Garza
Thanks to the improved survival outcomes observed in recent years, a growing attention has been given to the quality of life issues faced by young women with breast cancer such as fertility preservation and concerns related to future pregnancies. However, several challenges remain for young women with breast cancer considering undergoing fertility preservation strategies. Further specific issues on this regard should be taken into account in Latin America, where patients and physicians face particular barriers that hinder the routine adoption of this practice...
March 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28453404/effects-of-biofilter-media-depth-and-moisture-content-on-removal-of-gases-from-a-swine-barn
#12
Tongshuai Liu, Hongmin Dong, Zhiping Zhu, Bin Shang, Fubin Yin, Wanqin Zhang, Tanlong Zhou
Media depth (MD) and moisture content (MC) are two important factors that greatly influence biofilters performance. The purpose of this study was to investigate the combined effect of MC and MD on removing ammonia (NH3), hydrogen sulfide (H2S), and nitrous oxide (N2O) from swine barns. Biofiltration performance of different MDs and MCs combination based on the mixed medium of wood chips and compost were monitored. A 3×3 factorial design was adopted, which included three levels of the two factors (MC: 45%, 55%, and 67% (wet basis); MD: 0...
April 28, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28453390/the-torments-of-the-cohesin-ring
#13
Alap P Chavda, Keven Ang, Dmitri Ivanov
Cohesin is a ring-shaped protein complex which comprises the Smc1, Smc3 and Scc1 subunits. It topologically embraces chromosomal DNA to connect sister chromatids and stabilize chromatin loops. It is required for proper chromosomal segregation, DNA repair and transcriptional regulation. We have recently reported that cohesin rings can adopt a "collapsed" rod-like conformation which is driven by the interaction between the Smc1 and Smc3 coiled coil arms and is regulated by post-translational modifications. The "collapsed" conformation plays a role in cohesin ring assembly and its loading on the DNA...
February 27, 2017: Nucleus
https://www.readbyqxmd.com/read/28453279/monte-carlo-simulations-of-the-uptake-of-chiral-compounds-on-solid-surfaces
#14
Stavros Karakalos, Francisco Zaera
A Monte Carlo algorithm was developed and used to describe and explain previous experimental results associated with the kinetics of the uptake of chiral molecules on solid surfaces. The specific system simulated in this study is the adsorption of propylene oxide (PO) on Pt(111) surfaces. The surface was represented by a square lattice, and the time evolution of the adsorption, starting from a clean surface, was simulated via a number of sequential events chosen using a stochastic approach based on the so-called Master equation and derived from the formalism advanced by Gillespie...
April 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28449400/a-novel-implementation-strategy-in-residential-care-settings-to-promote-ebp-direct-care-provider-perceptions-and-development-of-a-conceptual-framework
#15
Susan E Slaughter, Erin Bampton, Daniel F Erin, Carla Ickert, C Allyson Jones, Carole A Estabrooks
BACKGROUND: Innovative approaches are required to facilitate the adoption and sustainability of evidence-based care practices. We propose a novel implementation strategy, a peer reminder role, which involves offering a brief formal reminder to peers during structured unit meetings. AIMS: This study aims to (a) identify healthcare aide (HCA) perceptions of a peer reminder role for HCAs, and (b) develop a conceptual framework for the role based on these perceptions...
April 27, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28449396/exploring-guideline-adaptation-strategy-for-turkey-is-adapte-feasible-or-does-it-need-adaptation-as-well
#16
Duygu Ayhan Baser, Rabia Kahveci, Aylin Baydar Artantas, İlknur Yasar, Hilal Aksoy, Esra Meltem Koc, İsmail Kasim, Ilkka Kunnamo, Adem Özkara
RATIONALE, AIMS, OBJECTIVES: Clinical Practice Guidelines are mostly developed by 3 methods; namely, de novo, adoption, and adaptation. Nonpublished studies and authors experience shows that most guidelines in Turkey are either by adoption or by adaptation. There is no available local tool for adaptation, so the process is not standardized and most of the time not explicitly defined. The objective of this study is to search for international guideline adaptation tools and test their feasibility in Turkish context, to serve a final goal of developing a unique local strategic tool for guideline adaptation...
April 27, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28449392/osmotic-stress-decreases-complexity-underlying-the-electrophysiological-dynamic-in-soybean
#17
G F R Saraiva, A S Ferreira, G M Souza
Research rationale: Studies on plant electrophysiology are mostly focused on specific traits of single cells. Inspired by the complexity of the signaling network in plants and by analogies with neurons in human brains, we have sought for evidences of high complexity in the electrical dynamics of plant signaling and a likely relation with environmental cues. Central methods: An EEG-like standard protocol was adopted for high-resolution measurements of the electrical signal in Glycine max seedlings. The signals were continuously recorded in the same plants before and after the osmotic stimuli with a -2 MPa mannitol solution...
April 27, 2017: Plant Biology
https://www.readbyqxmd.com/read/28449310/rational-design-of-nanobody80-loop-peptidomimetics-towards-biased-%C3%AE-2-adrenergic-receptor-ligands
#18
Charlotte Martin, Samuel Moors, Mia Danielsen, Cecilia Betti, Cecilia Fabris, Daniel Sejer Pedersen, Els Pardon, Marion Peyressatre, Krisztina Fehér, Jose C Martins, Jesper Mosolff Mathiesen, May Morris, Nick Devoogdt, Vicky Caveliers, Frank De Proft, Jan Steyaert, Steven Ballet
G protein-coupled receptors (GPCRs) play an important role for many cellular responses, and as such their mechanism of action is of utmost interest. To gain insight into the active conformation of GPCRs, the X-ray crystal structures of Nanobody(Nb)-stabilized β2-adrenergic receptor (β2AR) have been reported. Nb80 in particular is able to bind the intracellular G protein binding site of β2AR and stabilize the receptors in an active conformation. Within Nb80, the complementarity-determining region 3 (CDR3) is responsible for most of the binding interactions...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28449097/creating-a-culture-of-collaboration-a-brief-history-of-academic-neurosurgery-in-washington-dc
#19
Alan Siu, Christopher J Neal, Hasan R Syed, Daniel R Felbaum, M Nathan Nair, Kevin M McGrail, Anthony J Caputy, Donald C Shields
Clinical neurosurgery has been practiced in the US capital for just over 100 years. As former residents and fellows of Drs. Harvey Cushing and Walter Dandy moved to the region, hospitals at Georgetown and George Washington Universities became early adopters of this new surgical discipline. Later academic neurosurgery programs were established at the National Institutes of Health, Walter Reed Medical Center, and Children's National Medical Center. Neurosurgical pioneers at these institutions developed new technologies and diagnostic procedures which continue to inform our current practice...
April 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28448939/environmental-impacts-of-producing-bioethanol-and-biobased-lactic-acid-from-standalone-and-integrated-biorefineries-using-a-consequential-and-an-attributional-life-cycle-assessment-approach
#20
Ranjan Parajuli, Marie Trydeman Knudsen, Morten Birkved, Sylvestre Njakou Djomo, Andrea Corona, Tommy Dalgaard
This study evaluates the environmental impacts of biorefinery products using consequential (CLCA) and attributional (ALCA) life cycle assessment (LCA) approaches. Within ALCA, economic allocation method was used to distribute impacts among the main products and the coproducts, whereas within the CLCA system expansion was adopted to avoid allocation. The study seeks to answer the questions (i) what is the environmental impacts of process integration?, and (ii) do CLCA and ALCA lead to different conclusions when applied to biorefinery?...
April 24, 2017: Science of the Total Environment
keyword
keyword
88660
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"