Read by QxMD icon Read

Cancer survivor fertility

Yuki Ito, Eriko Shiraishi, Atsuko Kato, Takayuki Haino, Kouhei Sugimoto, Aikou Okamoto, Nao Suzuki
PURPOSE: To identify the utility and issues associated with the use of decision trees in oncofertility patient care in Japan. METHODS: A total of 35 women who had been diagnosed with cancer, but had not begun anticancer treatment, were enrolled. We applied the oncofertility decision tree for women published by Gardino et al. to counsel a consecutive series of women on fertility preservation (FP) options following cancer diagnosis. Percentage of women who decided to undergo oocyte retrieval for embryo cryopreservation and the expected live-birth rate for these patients were calculated using the following equation: expected live-birth rate = pregnancy rate at each age per embryo transfer × (1 - miscarriage rate) × No...
October 20, 2016: Journal of Adolescent and Young Adult Oncology
Yong Jin Kim, Yoon Young Kim, Byeong-Cheol Kang, Moon Suk Kim, In Kap Ko, Hung Ching Liu, Zev Rosenwaks, Seung-Yup Ku
In vitro culture of ovarian follicles is a promising bioengineering technique for retrieving fertilizable oocytes from preserved ovarian tissues of cancer survivors. However, current in vitro follicle culture techniques are labour-intensive and of low efficiency, as only single follicle culture (SFC) has been possible to date. The present study investigated the feasibility of multifollicular cluster culture (MFCC) system using angiotensin II receptor (ATII-Rc) analogues. Ovarian pre-antral follicles isolated from 2-week-old C57BL6 mice were cultured with ATII-Rc agonist or antagonist and their maturation outcomes were compared with control group...
September 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
Stephania Casco, Elena Soto-Vega
Long-term childhood cancer survivors are at great risk of developing late adverse effects after treatment, such as, reduced growth, obesity, decreased fertility, high blood pressure, cardiovascular diseases, impaired glucose, another form of cancer, among others organ dysfunctions, some of them are part of the metabolic syndrome. Metabolic syndrome and cancer connection is still not entirely understood, but there are some notions about it. Metabolic alterations produced during childhood cancer are more likely determined by treatments like radiotherapy, chemotherapy, glucocorticoids therapy, and surgery...
October 4, 2016: Hormones & Cancer
Janine Vetsch, Joanna E Fardell, Claire E Wakefield, Christina Signorelli, Gisela Michel, Jordana K McLoone, Thomas Walwyn, Heather Tapp, Jo Truscott, Richard J Cohn
OBJECTIVE: This mixed-method study assessed 1) survivors' and parents' information needs; and 2) associations between unmet information needs and clinical and socio-demographic characteristics. METHODS: Stage 1: CCS and parents of CCS, >5years post-diagnosis completed a questionnaire on information needs, overall health and perceived risk. Predictors for unmet information needs were assessed by multivariable regression. Stage 2: participants were interviewed in-depth on these topics...
September 22, 2016: Patient Education and Counseling
Francesca Filippi, Cristina Meazza, Alessio Paffoni, Francesco Raspagliesi, Monica Terenziani, Edgardo Somigliana
Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an iatrogenic insult to the ovarian reserve, and there is no guarantee of use because not all girls will undergo re-implantation. Moreover, it is impossible to respect all the requested conditions for a valid informed consent...
September 29, 2016: Pediatrics
Javier Domingo, Juan A Garcia-Velasco
PURPOSE OF REVIEW: It is necessary to clarify the fertility preservation-related points of concern that often frighten patients or physicians when it comes to deciding about oocyte cryopreservation for fertility preservation, which are often perceived as procedure limitations, are sometimes real and often theoretical and may make the prognosis worse. RECENT FINDINGS: Letrozole added to gonadotrophins for controlled ovarian stimulation is safe when applied to hormone-sensitive cancer patients as it avoids associated high estradiol levels...
September 28, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
Helen B Chin, Penelope P Howards, Michael R Kramer, Ann C Mertens, Jessica B Spencer
OBJECTIVE: To assess which characteristics are associated with failure to receive fertility counseling among a cohort of young women diagnosed with cancer. DESIGN: Population-based cohort study. SETTING: Not applicable. PATIENT(S): A total of 1,282 cancer survivors, of whom 1,116 met the inclusion criteria for the analysis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The main outcome in this study was whether or not women reported receiving any information at the time of their cancer diagnosis on how cancer treatment might affect their ability to become pregnant...
September 24, 2016: Fertility and Sterility
Seline Tam, Natasha Puri, Derek Stephens, Laura Mitchell, Meredith Giuliani, Janet Papadakos, Abha A Gupta
Adolescent and young adult (AYA) cancer patients under 40 should be made aware of their fertility risks and preservation options throughout their care. However, discussions on fertility preservation (FP) do not routinely occur. With a dearth of FP resources, oncology providers may lack knowledge around FP. Thus, informational needs can be unmet, leading to anxiety and distress in patients. Provision of pertinent and timely information can help patients cope better with their diagnosis. FP pamphlets were developed for men and women with cancer...
September 27, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
P Rema, Iqbal Ahmed
There is a rising incidence of early cervical cancer in young patients as a result of screening and early detection. Treatment of cervical cancer by surgery or radiotherapy results in permanent infertility which affects the quality of life of cancer survivors. Now with improved survival rates among early cervical cancer patients, conservative surgery aiming at fertility preservation in those desiring future pregnancy is an accepted treatment. Conservative surgery is possible in early cervical cancer including micro invasive cancer and stage IB cancers less than 2 cm...
September 2016: Indian Journal of Surgical Oncology
C E Dunlop, B M Brady, M McLaughlin, E E Telfer, J White, F Cowie, S Zahra, W H B Wallace, R A Anderson
With the improvement of long-term cancer survival rates, growing numbers of female survivors are suffering from treatment-related premature ovarian insufficiency (POI). Although pre-treatment embryo and oocyte storage are effective fertility preservation strategies, they are not possible for pre-pubertal girls or women who cannot delay treatment. In these cases, the only available treatment option is ovarian cortex cryopreservation and subsequent re-implantation. A 32-year-old woman had ovarian cortex cryopreserved 10 years previously before commencing high-dose chemotherapy and undergoing a haematopoietic stem cell transplant for recurrent adult Wilms tumour, which resulted in POI...
September 17, 2016: Journal of Assisted Reproduction and Genetics
Ahmed A Hussein, Pamela Yango, Youseff Ezz, James F Smith, Nam D Tran
Infertility is a common disease affecting 10-15% of reproductive couples with significant psychological and financial impacts to both patients and society. Approximately 80 million people worldwide are infertile, with an increasing incidence of male infertility. Semen cryopreservation in adults is a proven method of fertility preservation for male patients undergoing gonadal toxic therapies. Unlike adults who can cryopreserve sperm at any time prior to gonadal toxic treatments, there are no effective fertility preservation options for children undergoing cancer treatment, a time when semen cryopreservation is not feasible...
December 2016: Minerva Ginecologica
Deepa Bhartiya, Ambreen Shaikh, Sandhya Anand, Hiren Patel, Sona Kapoor, Kalpana Sriraman, Seema Parte, Sreepoorna Unni
BACKGROUND: Both pluripotent very small embryonic-like stem cells (VSELs) and induced pluripotent stem (iPS) cells were reported in 2006. In 2012, a Nobel Prize was awarded for iPS technology whereas even today the very existence of VSELs is not well accepted. The underlying reason is that VSELs exist in low numbers, remain dormant under homeostatic conditions, are very small in size and do not pellet down at 250-280g. The VSELs maintain life-long tissue homeostasis, serve as a backup pool for adult stem cells and are mobilized under stress conditions...
September 10, 2016: Human Reproduction Update
H Irene Su, Meghan W Connell, Lyudmila A Bazhenova
OBJECTIVE: To describe a clinical approach to and outcomes of IVF in reproductive-aged cancer survivors receiving targeted cancer therapies. DESIGN: Case report. SETTING: Academic fertility preservation program. PATIENT(S): The first case is of a female patient with metastatic lung cancer receiving long-term crizotinib, an anaplastic lymphoma kinase inhibitor. The second case is of a female patient with metastatic colon cancer receiving long-term denosumab, a RANKL antibody...
August 23, 2016: Fertility and Sterility
Lauren Matheson, Mary Boulton, Verna Lavender, Graham Collins, Tracy Mitchell-Floyd, Eila Watson
PURPOSE/OBJECTIVES: To explore the experiences of young adults with Hodgkin lymphoma during the first year following the end of initial treatment. 
. RESEARCH APPROACH: A qualitative grounded theory study.
. SETTING: Interviews with patients recruited from three cancer centers in England.
. PARTICIPANTS: 10 Hodgkin lymphoma survivors (four men and six women aged 21-39 years) recruited as part of a larger study of 28 young adult cancer survivors...
September 1, 2016: Oncology Nursing Forum
Dina M Flink, Jeanelle Sheeder, Laxmi A Kondapalli
PURPOSE: The American Society of Clinical Oncology issued practice guidelines in 2006 to provide critical information about fertility impact to adolescents and young adults (AYA) at the time of cancer diagnosis. Survivors continue to express concerns about their long-term reproductive health after cancer therapy even as treatment options for fertility preservation evolve. An underutilization of fertility preservation methods by cancer patients continues to persist. A review of the literature cites barriers and challenges that limit fertility information and preservation options for AYA cancer patients...
August 16, 2016: Journal of Adolescent and Young Adult Oncology
Jessica L Chan, Joseph Letourneau, Wael Salem, Aylin Pelin Cil, Sai-Wing Chan, Lee-May Chen, Mitchell P Rosen
PURPOSE: Data have demonstrated an association between regret and lack of fertility counseling among patients undergoing treatment for non-gynecologic cancers. We sought to determine if fertility-related regret is reduced with pre-treatment counseling or fertility-sparing surgery (FSS) in patients with gynecologic cancers. METHODS: A cross-sectional survey was administered to 593 reproductive-age survivors (18-40 years old at diagnosis) of localized cervix, ovarian, or endometrial cancers that were eligible for FSS...
August 1, 2016: Journal of Cancer Survivorship: Research and Practice
Jennifer Gass, Beth Dupree, Sandhya Pruthi, Diane Radford, Irene Wapnir, Reza Antoszewska, Audrey Curtis, Nathalie Johnson
Survivorship medicine is fairly new in the realm of oncology. As we broaden our focus from treatment and prevention to include survivorship there is substantial opportunity to enhance the care of the patient. Important in successful management of recovery after cancer treatment is managing the side effects of therapy and improving quality of life. This ranges from sexual dysfunction, depression to lymphedema. Guideline-based surveillance after treatment with clear communication of care plans to the patient and their providers, especially primary care, is paramount...
October 2016: Annals of Surgical Oncology
Giuliano Bedoschi, Paula Andrea Navarro, Kutluk Oktay
Cancer is a major public health problem around the world. Currently, about 5% of women diagnosed with cancer are of reproductive age. These young survivors may face compromised fertility. The effects of chemotherapeutic agents on ovarian reserve and its clinical consequences are generally inferred from a variety of surrogate markers of ovarian reserve, all aiming to provide prognostic information on fertility or the likelihood of success of infertility treatment. Until recently, the mechanisms that are responsible for chemotherapy-induced ovarian damage were not fully elucidated...
October 2016: Future Oncology
Akiko Abe, Akira Kuwahara, Takeshi Iwasa, Masato Nishimura, Minoru Irahara
BACKGROUND: Treatment-related infertility is an important issue for cancer survivors of reproductive age. We aimed to determine the understanding and management of fertility issues in cancer survivors by health care providers. METHODS: We studied 112 patients aged 15-40 years who underwent chemotherapy in Tokushima University Hospital. The gynecologists and oncologists who treated these patients were surveyed regarding their concerns about infertility issues in young cancer survivors...
July 11, 2016: International Journal of Clinical Oncology
Juan J Tarín, Miguel A García-Pérez, Antonio Cano
BACKGROUND: Literature shows the effects of type of cancer and/or anticancer treatment on live birth percentages and/or pregnancy and neonatal complications in female cancer survivors. However, studies analyzing the obstetric and offspring risks of the morbid conditions associated with previous anti-cancer treatments are missing. The present review aims to uncover these risks. METHODS: A literature search based on publications up to March 2016 identified by PubMed and references cited in relevant articles...
2016: Reproductive Biology and Endocrinology: RB&E
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"