Read by QxMD icon Read

Cancer survivor fertility

Marie-Estelle Gaignard, Julie Bénard, Noémie Lang
Every year, cancer affects more than a million adolescents and young adults (AYA) in high-income countries. AYA patients represent a heterogeneous but distinct population, aged from 15 to 39 (-45) years old, among which different types of cancer are found compared to the ones affecting children and older adults. Although these pathologies remain the leading cause of death in the AYA age range, the survival rate in this population has significantly improved in recent years, averaging 85%. The aim of this article is to review one major issue in AYA survivors, which is the risk of impaired fertility due to oncological treatments, and the different strategies available to address this problem...
March 14, 2018: Revue Médicale Suisse
Leena Nahata, Nicole M Caltabellotta, Nicholas D Yeager, Vicky Lehmann, Stacy L Whiteside, Sarah H O'Brien, Gwendolyn P Quinn, Cynthia A Gerhardt
Infertility is a common and distressing late effect of cancer treatment among male survivors. Investigators examined desire for parenthood, prioritization of fertility compared to other life goals, and reports of fertility-related discussions among a cohort of male adolescent and young adult survivors. Eighty percent desired a biological child, yet only 31% ranked having a child among their "top 3" life goals. Only 40% reported fertility-related discussions with their health care providers in survivorship...
March 14, 2018: Pediatric Blood & Cancer
Esther L Finney, Emilie K Johnson
No abstract text is available yet for this article.
March 12, 2018: Pediatric Blood & Cancer
Maria Olsson, Gunnar Steineck, Karin Enskär, Ulrica Wilderäng, Marianne Jarfelt
PURPOSE: Previous research has established that treatments for cancer can result in short- and long-term effects on sexual function in adult cancer patients. The purpose was to investigate patient-reported physical and psychosexual complications in adolescents and young adults after they have undergone treatment for cancer. METHODS: In this population-based study, a study-specific questionnaire was developed by a method used in several previous investigations carried out by our research group, Clinical Cancer Epidemiology...
March 5, 2018: Journal of Cancer Survivorship: Research and Practice
Asma Javed, Zaraq Khan, Siobhan T Pittock, Jani R Jensen
Fertility preservation therapies can conserve future reproductive potential for persons facing serious medical diagnoses. With cure rates for childhood cancer reaching almost 80%, quality-of-life concerns for long-term survivors, including future parenting, are becoming more pertinent. Late effects of childhood cancer can be divided into physical, social, psychological, and spiritual domains. Potential loss of fertility threatens the well-being of these children in all these domains. Providers often hesitate to discuss fertility preservation with the patients...
March 2018: Pediatric Endocrinology Reviews: PER
Vicky Lehmann, Leena Nahata, Amanda C Ferrante, Jennifer A Hansen-Moore, Nicholas D Yeager, James L Klosky, Cynthia A Gerhardt
PURPOSE: To present an overview of fertility-related perceptions and describe the perceived negative/positive impact of (potential) infertility on romantic relationships among childhood cancer survivors. METHODS: Male and female long-term childhood cancer survivors (N = 92) aged 22-43 and 7-37 years postdiagnosis, completed an online survey about fertility-related perceptions (i.e., knowledge, beliefs, uncertainty, concern, and attitudes toward testing) and romantic relationships...
February 21, 2018: Journal of Adolescent and Young Adult Oncology
F Cappuccio, S Rossetti, C Cavaliere, G Iovane, R Taibi, C D'Aniello, C Imbimbo, S Facchini, V Abate, D Barberio, G Facchini
OBJECTIVE: In this review, we focused our attention on Quality of Life (QoL) of testicular cancer survivors (TCSs), in general and in the most relevant areas. Several key findings have been highlighted in our review. MATERIALS AND METHODS: PubMed, MEDLINE and PsycINFO databases were consulted to find published studies, from 1980 to May 2017, that met our inclusion criteria. RESULTS: The majority of studies investigated older adult TCSs, while few studies on adolescent and young adult patients were available...
February 2018: European Review for Medical and Pharmacological Sciences
Lisa M Shandley, Amy Fothergill, Jessica B Spencer, Ann C Mertens, Hanh N Cottrell, Penelope P Howards
OBJECTIVE: To compare markers of fertility and ovarian reserve between cancer survivors and cancer-free women with and without polycystic ovary syndrome (PCOS). DESIGN: Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women's Study-a population-based cohort study. SETTING: Not applicable. PATIENT(S): Female cancer survivors (n = 1,090) aged 22-45 years, diagnosed between ages 20 and 35 years, and at least 2 years after diagnosis; 369 participated in a clinic visit...
February 7, 2018: Fertility and Sterility
Taryn Sandheinrich, Sarah B Wondmeneh, Caroline Mohrmann, Katie Gettinger, Jennifer Henry, Robert J Hayashi
PURPOSE: The purpose of this study was to assess knowledge and perceptions of infertility, reproductive concerns, quality of life, and emotional burden of fertility concerns in adolescent female cancer survivors and their parents. METHODS: A cross-sectional design was used to investigate reproductive knowledge and concerns among female childhood cancer survivors and their parents. The instruments administered at a single, routine visit were the 13-item knowledge instrument, Adolescent Fertility Values Clarification Tool (VCT), Impact of Event Scale (IES), and Pediatrics Quality of Life Assessment (PedsQL)...
February 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Parathan Karunakaran, Pankaj Malhotra, Deepesh Lad
For cancer survivors, social parenthood buffers distress and improves quality of life. It is important that physicians dealing with treatment of malignancies are aware of this patient perspective. This review deals with risks of infertility with hematological malignancies and chemotherapy, modes of fertility preservation interventions, time and barriers to referral to specialists offering these interventions. This review aims to guide the hemato-oncologist to make an informed decision with the patient and the partner about fertility preservation at the right time...
January 2018: Indian Journal of Hematology & Blood Transfusion
Catherine Benedict, Bridgette Thom, Danielle N Friedman, Elaine Pottenger, Nirupa Raghunathan, Joanne F Kelvin
BACKGROUND: Cancer treatment may lead to premature menopause and infertility. Young adult female cancer survivors (YAFCS) are often concerned about their fertility and future family-building options, but research is limited on how concerns may affect more general quality of life (QOL) domains. This study examined how fertility factors relate to QOL among YAFCS who received gonadotoxic therapy. METHOD: A national sample of YAFCS completed an online, anonymous survey...
February 1, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ellie Smart, Federica Lopes, Siobhan Rice, Boglarka Nagy, Richard A Anderson, Rod T Mitchell, Norah Spears
Long term survival rates for childhood cancers is steadily increasing, however cancer survivors can experience fertility problems as a consequence of chemotherapy treatment. This is particularly problematic for young boys, for whom no fertility preservation treatment is yet established. Here, we have determined the effects on prepubertal mouse testis of three commonly used chemotherapy drugs; cyclophosphamide (using its active metabolite phosphoramide mustard), cisplatin and doxorubicin, exposing testicular fragments to a clinically relevant range of concentrations in vitro...
January 29, 2018: Scientific Reports
Hoon Kim, Seul Ki Kim, Jung Ryeol Lee, Kyung Joo Hwang, Chang Suk Suh, Seok Hyun Kim
With advances in the methods of cancer treatment used in modern medicine, the number of breast cancer survivors has been consistently rising. As the number of women who wish to become pregnant after being diagnosed with breast cancer increases, it is necessary to consider fertility preservation in these patients. However, medical doctors may be unaware of the importance of fertility preservation among cancer patients because most patients do not share their concerns about fertility with their doctors. Considering the time spent choosing and undergoing treatment, an early referral to a reproductive specialist is the best way to prevent a delay in cancer treatment...
December 2017: Clinical and Experimental Reproductive Medicine
Maria Olsson, Karin Enskär, Gunnar Steineck, Ulrica Wilderäng, Marianne Jarfelt
OBJECTIVE: Cancer treatment may result in various effects that last long after treatment has been concluded. The purpose of this study was to explore to what extent scars affect adolescents and young adults postcancer treatment. METHODS: In this population-based study, a study-specific questionnaire was developed by a method used in several previous investigations carried out by our research group, Clinical Cancer Epidemiology. Question development involved expert validation by professionals from oncology units, midwives, epidemiologists, and statisticians...
January 26, 2018: Journal of Adolescent and Young Adult Oncology
Karen C Burns, Holly Hoefgen, Andrew Strine, Roshni Dasgupta
The incidence of childhood cancer has steadily increased since the 1950s, with approximately 16,000 children diagnosed each year. However, with the advent of more effective multimodal therapies, childhood cancer survival rates have continued to improve over the past 40 years, with >80% of patients now surviving into adulthood. Fertility preservation (FP) has become an important quality-of-life issue for many survivors of childhood cancer. As a result, the therapeutic options have become less gonadotoxic over time and more patients are being offered FP options...
January 25, 2018: Cancer
Ines Vaz-Luis, Ann H Partridge
Considerable controversy exists regarding the safety of elective exogenous hormonal exposure among breast cancer survivors and women at high risk of developing the disease (referred to herein as 'previvors'). We performed a qualitative analysis focused on four areas of potential exogenous exposure to hormones among previvors and survivors: hormonal contraception; systemic hormone-replacement therapy (HRT); localized HRT; and hormonal manipulation for fertility preservation or enhancement. Herein, we discuss the available data and present clinical recommendations regarding the safety of hormonal exposure for both previvors and survivors...
January 23, 2018: Nature Reviews. Clinical Oncology
Molly B Moravek, Rafael Confino, Kristin N Smith, Ralph R Kazer, Susan C Klock, Angela K Lawson, William J Gradishar, Mary Ellen Pavone
OBJECTIVE: To compare long-term outcomes of cancer patients who pursued fertility preservation (FP) with those who did not and compare random-start (RS) and menstrual cycle-specific (CS) protocols for FP. DESIGN: Retrospective cohort. SETTING: Single urban academic institution. PATIENT(S): Oncology patients who contacted the FP patient navigator, 2005-2015. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Time to cancer treatment, disease-free survival, and reproductive outcomes in FP versus no-FP patients and cycle outcomes for RS versus CS protocols...
January 12, 2018: Fertility and Sterility
Jennifer M Levine, John A Whitton, Jill P Ginsberg, Daniel M Green, Wendy M Leisenring, Marilyn Stovall, Leslie L Robison, Gregory T Armstrong, Charles A Sklar
BACKGROUND: Survivors of childhood cancer are at risk of nonsurgical premature menopause (NSPM). To the authors' knowledge, risk factors for NSPM and its impact on reproduction remain poorly defined. METHODS: The menopausal status of 2930 survivors diagnosed between 1970 and 1986 (median age, 6 years [range, birth-20 years]) who were aged > 18 years at the time of the current study (median age, 35 years [range, 18-58 years]) was compared with 1399 siblings...
January 16, 2018: Cancer
Jane Ireson, Georgina Jones, Matthew C Winter, Stephen C Radley, Barry W Hancock, John A Tidy
Gestational trophoblastic disease is a rare complication of pregnancy that can develop into cancer. Medical outcomes of gestational trophoblastic disease are well researched, but the effect of the disease on health-related quality of life (HRQOL) requires attention if care is to be improved. This systematic review was designed to establish the effect of gestational trophoblastic disease and its treatment on HRQOL and to identify the appropriateness of HRQOL measures. Quantitative studies found HRQOL in long-term survivors of gestational trophoblastic disease to be at or above population norms...
January 2018: Lancet Oncology
Asif Husain Osmani, Ghulam Haider, Shaharzad Ali, Faiza Ali, Munazza Irfan, Dur e Fatima
Introduction: Infertility after cancer treatment can cause significant emotional stress and grief for cancer survivors. In this study we assessed knowledge and perceptions among young cancer patients regarding the topic of cancer and infertility related to different treatment options. Material and Methods: This cross-sectional study was conducted on young cancer patients in the Clinical Oncology Department, JPMC, Karachi, from January to August 2013. Patients were requested to fill in questionnaires. Comparisons between gender and age groups were performed using the Student’s t test and Pearson’s Chi-squared...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"