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Cancer survivor fertility

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https://www.readbyqxmd.com/read/28526012/the-pregnancy-and-fertility-prefer-study-an-italian-multicenter-prospective-cohort-study-on-fertility-preservation-and-pregnancy-issues-in-young-breast-cancer-patients
#1
Matteo Lambertini, Paola Anserini, Valeria Fontana, Francesca Poggio, Giuseppina Iacono, Annalisa Abate, Alessia Levaggi, Loredana Miglietta, Claudia Bighin, Sara Giraudi, Alessia D'Alonzo, Eva Blondeaux, Davide Buffi, Francesco Campone, Domenico F Merlo, Lucia Del Mastro
BACKGROUND: Fertility and pregnancy issues are of key importance for young breast cancer patients. Despite several advances in the field, there are still multiple unmet needs and barriers in discussing and dealing with these concerns. To address the significant challenges related to fertility and pregnancy issues, the PREgnancy and FERtility (PREFER) study was developed as a national comprehensive program aiming to optimize care and improve knowledge around these topics. METHODS: The PREFER study is a prospective cohort study conducted across several Italian institution affiliated with the Gruppo Italiano Mammella (GIM) group evaluating patterns of care and clinical outcomes of young breast cancer patients dealing with fertility and pregnancy issues...
May 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28515261/life-after-treatment-quality-of-life-concerns-in-patients-treated-for-cancer
#2
Mindy E Goldman
Traditionally, the physical, psychological, and psychosocial long-term needs of cancer survivors have received little attention compared with screening for cancer recurrence and secondary cancers. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Survivorship offer recommendations for various survivorship concerns, and those for improving menopausal symptoms were presented at the NCCN 22nd Annual Conference. Key considerations in managing menopausal symptoms in cancer survivors were reviewed, with chemotherapy-induced amenorrhea, fertility concerns, and both hormonal and nonhormonal therapeutic options featured...
May 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28503254/management-of-potential-long-term-toxicities-in-breast-cancer-patients
#3
C C O'Sullivan, K J Ruddy
Breast cancer is the most common non-cutaneous malignancy among women, and there are over 3 million breast cancer survivors living in the United States today. Excellent cure rates with modern therapies are associated with substantial toxicities for many women; it is important that health care providers attend to the resulting symptoms and issues to optimize quality of life in this population. In this article, we review management options for potential long term toxicities in breast cancer survivors, with a particular focus on bone health, fertility preservation, premature menopause, cardiac dysfunction, and cognitive impairment...
December 2016: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28490359/cryopreservation-of-reproductive-material-before-cancer-treatment-a-qualitative-study-of-health-care-professionals-views-about-ways-to-enhance-clinical-care
#4
Karin Hammarberg, Maggie Kirkman, Catharyn Stern, Robert I McLachlan, Debra Gook, Luk Rombauts, Beverley Vollenhoven, Jane R W Fisher
BACKGROUND: Cancer treatment can diminish fertility in women and men. The need for fertility preservation is growing as increasing numbers of people survive cancer. Cryostorage of reproductive material to preserve potential for conception for cancer survivors has moved from being experimental to being a part of clinical management of women and men who are diagnosed with cancer in their reproductive years. There is little existing evidence about how fertility preservation services can be enhanced to meet the complex needs of patients who are diagnosed with cancer in their reproductive years...
May 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28463858/physical-long-term-side-effects-in-young-adult-cancer-survivors-germ-cell-tumors-model
#5
Hampig Raphael Kourie, Jean Klastersky
PURPOSE OF REVIEW: After the important advances in the treatment of germ cell tumors (GCTs) leading to high cure rates, physical long-term side-effects represent an important cause of death in these young adult survivors. Highlighting these physical long-term side-effects, their monitoring and their prevention modalities is necessary for a better management of these cancer survivors. RECENT FINDINGS: Impaired fertility, increased risk of developing a second cancer, cardiac, pulmonary, renal and neural toxicity, hearing and vision impairment are the major physical side-effects in young adult cancer survivors...
April 29, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28458460/childbirth-and-fertility-preservation-in-childhood-and-adolescent-cancer-patients-a-second-national-survey-of-japanese-pediatric-endocrinologists
#6
Yoko Miyoshi, Tohru Yorifuji, Reiko Horikawa, Ikuko Takahashi, Keisuke Nagasaki, Hiroyuki Ishiguro, Ikuma Fujiwara, Junko Ito, Mari Oba, Hiroyuki Fujisaki, Masashi Kato, Chikako Shimizu, Tomoyasu Kato, Kimikazu Matsumoto, Haruhiko Sago, Tetsuya Takimoto, Hiroshi Okada, Nao Suzuki, Susumu Yokoya, Tsutomu Ogata, Keiichi Ozono
Although existing guidelines recommend long-term follow-up of childhood cancer survivors (CCSs), their fertility has not been fully investigated in Japan. To address this issue, we organized a working panel consisting of medical specialists in foundation hospitals. We conducted questionnaire surveys targeting pediatric endocrinologists regarding reproduction in pediatric and adolescent cancer patients in collaboration with the CCS committee of the Japanese Society for Pediatric Endocrinology (JSPE). The first questionnaire was sent to 178 directors or councilors of the JSPE, and the second was sent to those who had provided answers on their experience with childbirth or fertility preservation...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28453508/viable-options-for-fertility-preservation-in-breast-cancer-patients-a-focus-on-latin-america
#7
Matteo Lambertini, Oranite Goldrat, Regina Barragan-Carrillo, Giulia Viglietti, Isabelle Demeestere, Cynthia Villarreal-Garza
Thanks to the improved survival outcomes observed in recent years, a growing attention has been given to the quality of life issues faced by young women with breast cancer such as fertility preservation and concerns related to future pregnancies. However, several challenges remain for young women with breast cancer considering undergoing fertility preservation strategies. Further specific issues on this regard should be taken into account in Latin America, where patients and physicians face particular barriers that hinder the routine adoption of this practice...
March 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28444134/characterization-of-foxo1-3-and-4-transcription-factors-in-ovaries-of-fetal-prepubertal-and-adult-rhesus-macaques
#8
Alison Y Ting, Mary B Zelinski
The phosphoinositide 3-kinase/AKT signaling pathway negatively regulates follicle activation via the forkhead box O (FOXO) transcription factor in rodents. FOXO3 knockout mice exhibit global activation of primordial follicles leading to early depletion of ovarian follicles and subsequent infertility. Whether a similar mechanism for follicle activation exists in the primate ovary is unclear. In the current study, protein localization of FOXO1, 3 and 4 as well as their upstream regulator, AKT/p-AKT, were examined in rhesus macaque ovaries of 3 developmental stages: fetal, prepubertal and adult...
April 22, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28408620/oncofertility-fertile-ground-for-conflict-between-patient-autonomy-and-medical-values
#9
Sarah K Walsh, Elizabeth S Ginsburg, Lisa Soleymani Lehmann, Ann H Partridge
Oncofertility is a unique, multidisciplinary field that serves to bridge the gap between available fertility resources and the special reproductive needs of cancer patients. Oncofertility is a growing field due to the increasing number of survivors, development of new oncologic therapies, extension of duration of therapies, and development and refinement of reproductive therapies. While the technologies and demand for services expand, clinicians need to be appropriately prepared for dealing with various clinical scenarios that may require ethical deliberation...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28398024/gonadotropin-releasing-hormone-analogues-for-the-prevention-of-chemotherapy-induced-premature-ovarian-failure-in-breast-cancer-patients
#10
Benedetta Conte, Lucia Del Mastro
Since the survival of patients with cancer has significantly improved, chemotherapy-related premature ovarian failure (POF) in young cancer survivors has become a major issue in oncology. POF is associated with several health-related negative consequences, including menopausal symptoms, increased risk of cardiovascular diseases, osteoporosis, sexual disfunction, and infertility1-5. According to the major international guidelines, embryo/oocyte cryopreservation are the standard procedures for fertility preservation in young cancer women6,7...
April 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28376233/a-call-for-fertility-preservation-coverage-for-breast-cancer-patients-the-cost-of-consistency
#11
Jessica R Walter, Shuai Xu, Teresa K Woodruff
In 1998, the passage of the Women's Health and Cancer Rights Act required insurance health plans nationwide covering breast cancer treatments to also reimburse for subsequent breast reconstructive surgery and prostheses. In response to low utilization of breast reconstructive services, particularly among racial minorities, plastic surgery interest groups successfully advocated for the passage of the Breast Cancer Patient Education Act, which provides a timely opportunity to reconsider patient accessibility to other equally important quality of life issues for cancer survivors...
May 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28369566/providing-written-information-increases-patient-satisfaction-a-web-based-questionnaire-survey-of-japanese-cancer-survivors
#12
Hitomi Sakai, Noriyuki Katsumata, Miyako Takahashi
Purpose: The Institute of Medicine (IOM) of the United States recommends that all cancer survivors be provided with a survivorship care plan (SCP), which includes a patient treatment summary and a follow-up care plan. However, SCPs have not been widely adopted in Japan. To provide basic data necessary for implementing SCPs in Japan, we aimed to investigate the forms of clinical and survivorship-related information that Japanese cancer survivors receive from their healthcare providers, and to examine whether written information increases their satisfaction...
March 23, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28368472/premature-ovarian-insufficiency-in-childhood-cancer-survivors-a-report-from-the-st-jude-lifetime-cohort
#13
Wassim Chemaitilly, Zhenghong Li, Matthew J Krasin, Russell J Brooke, Carmen L Wilson, Daniel M Green, James L Klosky, Nicole Barnes, Karen L Clark, Jonathan B Farr, Israel Fernandez-Pineda, Michael W Bishop, Monika Metzger, Ching-Hon Pui, Sue C Kaste, Kirsten K Ness, Deo Kumar Srivastava, Leslie L Robison, Melissa M Hudson, Yutaka Yasui, Charles A Sklar
Context: Long-term follow-up data on premature ovarian insufficiency (POI) in childhood cancer survivors are limited. Context: To describe the prevalence of POI, its risk factors and associated long-term adverse health outcomes. Design: Cross-sectional. Setting: The St. Jude Lifetime Cohort Study - established cohort in a tertiary care center. Patients: 921 participants (median age 31.7 years) were evaluated at a median of 24...
March 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28364312/physical-and-social-characteristics-and-support-needs-of-adult-female-childhood-cancer-survivors-who-underwent-hormone-replacement-therapy
#14
Akiko Tomioka, Mitsue Maru, Kenichi Kashimada, Hideya Sakakibara
BACKGROUND: Female childhood cancer survivors who develop gonadal dysfunction require female hormone replacement therapy (HRT) from puberty until menopause. However, the support provided in such cases has not been studied. We investigated the physical and social characteristics and support needs of adult female childhood cancer survivors who underwent HRT. METHODS: Forty-nine adult female childhood cancer survivors completed self-administered questionnaires. We compared the clinical characteristics, health status, and social conditions between a group that underwent HRT and a group that did not, and we surveyed support needs of the group that underwent HRT...
March 31, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28357785/patterns-of-unmet-needs-in-adolescent-and-young-adult-aya-cancer-survivors-in-their-own-words
#15
Alex W K Wong, Ting-Ting Chang, Katrina Christopher, Stephen C L Lau, Lynda K Beaupin, Brad Love, Kim L Lipsey, Michael Feuerstein
PURPOSE: Categorization of the needs of AYA cancer survivors is primarily based on quantitative analyses of epidemiological and observational research. The present study classified the phenomenological experiences of AYA survivors based on their own language. METHODS: A systematic approach for selecting qualitative studies of unmet needs in AYA cancer survivors was used. Following selection based on quality, survivor statements were entered verbatim and thematic analysis was conducted using NVivo qualitative research software...
March 29, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28339338/fertility-treatments-among-female-cancer-survivors-giving-birth-a-finnish-register-based-study
#16
Johanna Melin, Laura Madanat-Harjuoja, Sirpa Heinävaara, Nea Malila, Mika Gissler, Aila Tiitinen
BACKGROUND: Long-term survival rates for most types of childhood cancers have improved dramatically over the past decades. However, because of advances in multimodality treatments, cancer survivors nowadays more often face long-term complications, including diminished gonadal and reproductive function. The aim of this study was to identify whether the use of fertility treatments among early onset (0-34 years) cancer survivors giving birth differed from that among siblings giving birth and to identify the subgroups of cancer survivors that were most likely to require fertility treatments...
March 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28333312/establishment-maintenance-and-functional-integrity-of-the-blood-testis-barrier-in-organotypic-cultures-of-fresh-and-frozen-thawed-prepubertal-mouse-testes
#17
C Rondanino, A Maouche, L Dumont, A Oblette, N Rives
STUDY QUESTION: Can the spatio-temporal formation of an intact blood-testis barrier (BTB), which is essential for the progression of spermatogenesis, be reproduced in cultures of fresh or frozen/thawed prepubertal mouse testes? SUMMARY ANSWER: Organotypic cultures allow the establishment and maintenance of major BTB components and the formation of a functional BTB in mouse testicular tissues. WHAT IS KNOWN ALREADY: In vitro maturation of prepubertal testicular tissues is a promising approach to restore fertility in adult survivors of childhood cancer...
May 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333032/ethical-moral-and-other-aspects-related-to-fertility-preservation-in-cancer-patients
#18
Bruno Ramalho de Carvalho, Jhenifer Kliemchen, Teresa K Woodruff
Post-treatment fertility emerges as an important issue in the early counseling of individuals with cancer, since survivors may have their quality of life affected by the occurrence of functional failure of the gonads because of antineoplastic therapies. In the context, oncofertility has been developed as an interdisciplinary field of study that combines expertise in reproductive medicine and oncology, to provide strategies aiming to maintain the possibility of future procreation. Today, we have many options and techniques available for the preservation of gametes in men and women...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28278533/fertility-preservation-in-2016-where-are-we
#19
Anu David, Lisa Jeannette Green, Ariella Shikanov
This review focuses on advances in the field of fertility preservation achieved over the past few decades. The main purpose of fertility preservation is to help young cancer survivors retain their fertility by restoring either their ability to procreate or simply their reproductive endocrine function. Although different options are available in this regard, successful fertility preservation is yet to reach its full potential. Herein, we review the most significant work conducted over the past five decades and present new methodologies...
March 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28275393/psychological-impact-of-fertility-preservation-techniques-in-women-with-gynaecological-cancer
#20
EDITORIAL
Antonio Simone Laganà, Valentina Lucia La Rosa, Agnese Maria Chiara Rapisarda, Alessio Platania, Salvatore Giovanni Vitale
Gynaecological cancer is a very stressful experience for women and treatments can compromise fertility and reproductive capacity. Fertility preservation techniques in women with gynaecological cancer can play an important role in improving the quality of life of these patients but, in many cases, the information about this type of treatment is not adequate. It is important to further investigate this topic in order to reduce the impact of gynaecological cancer on the quality of life of survivors as much as possible...
2017: Ecancermedicalscience
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