Third party

Off-label use of pharmaceuticals involves a wide array of aspects ranging from legal and regulatory ones to clinical to safety considerations. Access to off-label therapies is particularly relevant question for patients in areas of unmet medical need. Simultaneously, off-label use also triggers wider considerations relating to social and economic sustainability of health care systems and access to health. National authorities have adapted different regulatory approaches to off-label use of pharmaceuticals, ranging from (1) "regulatory silence"; to (2) allowing off-label use at the discretion of the treating physician; and to (3) a more stringent approach in which off-label use is subject to third party approval...

Super-resolution and single-molecule microscopies have been increasingly applied to complex biological systems. A major challenge of these approaches is that fluorescent puncta must be detected in the low signal, high noise, heterogeneous background environments of cells and tissue. We present RASP, Radiality Analysis of Single Puncta, a bioimaging-segmentation method that solves this problem. RASP removes false-positive puncta that other analysis methods detect and detects features over a broad range of spatial scales: from single proteins to complex cell phenotypes...

Retraction: "Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q10 on hippocampal injury in mouse" by Mansoureh Soleimani, Fereshteh Golab, Akram Alizadeh, Sara Rigi, Zeinab Nazarian Samani, Gelareh Vahabzadeh, Tahmineh Peirovi, Maryam Sarbishegi, Majid Katebi, Fereshteh Azedi, J Cell Physiol 2019, 234: 18720-18730. The above article, published online on 1 April 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.28512) has been retracted by agreement between the journal's Editor in Chief, Alexander Hutchison, and the Wiley Periodicals LLC...

Retraction: "Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway", by Teng Zhao, Ying Ding, Min Li, Chunkui Zhou, and Weihong Lin, J Cell Physiol. 2019; 234: 16054-16067: The above article, published online on 25 February 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1002/jcp.28264) has been retracted by agreement between the journal's Editor in Chief, Alexander Hutchison, and Wiley Periodicals LLC...

(https://onlinelibrary.wiley.com/doi/10.1002/jcb.24742) has been retracted by agreement between the journal's Editor in Chief, Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. Several flaws and inconsistencies between results presented and experimental methods described were found. Thus, the editors consider the conclusions of this article to be invalid. The authors were not available for a final confirmation of the retraction...

Single Sign-On (SSO) methods are the primary solution to authenticate users across multiple web systems. These mechanisms streamline the authentication procedure by avoiding duplicate developments of authentication modules for each application. Besides, these mechanisms also provide convenience to the end-user by keeping the user authenticated when switching between different contexts. To ensure this cross-application authentication, SSO relies on an Identity Provider (IdP), which is commonly set up and managed by each institution that needs to enforce SSO internally...

The above article, published online on 28 March 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.28599) has been retracted by agreement between the journal's Editor in Chief, Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. Several flaws and inconsistencies between results presented and experimental methods described were found. Thus, the editors consider the conclusions of this article to be invalid...

BACKGROUND AND AIMS: Multiple sources of medical oxygen, namely liquid medical oxygen (LMO) tanks, pressure swing adsorption (PSA) plants, concentrators, and gaseous cylinders, are available at different healthcare facilities. These sources of oxygen have varying installation and operational costs. In low-resource settings, it is imperative to utilise these assets optimally. This study investigated the operational costs of multiple oxygen sources available at a healthcare facility. METHODS: A Microsoft (MS) Excel-based model was developed to analyse and compare the oxygen manufacturing costs (in ₹/m3 ) using PSA plants and procurement costs (in ₹/m3 ) of LMO and third-party vendor-refilled cylinders...

This is a case report of a 6-year-old girl with relapsed B cell acute lymphoblastic leukemia in which adoptive cell therapy was applied successfully to treat refractory human parvovirus (HPV) B19 infection. Allogenic chimeric antigen receptor (CAR) T-cell therapy (bispecific CD19/CD22) was bridged to hematopoietic stem cell transplantation (HSCT) using a haploidentical paternal donor. However, HPV B19 DNAemia progressed and transfusion-related graft versus host disease occurred. After finding a third-party related donor with a better HLA match, haploidentical HPV B19-seropositive CD45RA+ depleted cells (16...

BACKGROUND: Landmark clinical trials have expended the indications for the direct oral anticoagulants (DOACs), but contemporary data on usage and expenditure patterns are lacking. OBJECTIVE: This study aimed to assess annual trends in oral anticoagulant (OAC) utilization and expenditure across the United States (US) from 2014 to 2020. METHODS: We utilized the Medical Expenditure Panel Survey (MEPS) to study the trends of use and expenditures of warfarin, dabigatran, rivaroxaban, apixaban, and edoxaban between 2014 and 2020 in the US...

People experiencing incarceration (PEI) have poorer COVID-19 clinical outcomes compared with the general population. Many interventions were implemented in incarceration facilities to mitigate the burden of COVID-19. This systematic review seeks to analyze the effectiveness of these interventions. Twenty-two studies were included. Reduction of the incarcerated population/interfacility transfers, cohorting of new and infectious incarcerated people, mass asymptomatic testing (despite often low uptake), hygiene measures, and prioritization of PEI in vaccine policy had some evidence of effectiveness at reducing transmission and risk of COVID-19 in incarceration facilities...

BACKGROUND: Musculoskeletal injuries are common after road traffic crash (RTC) and can lead to poor work-related outcomes. This review evaluated the impact of interventions on work-related (e.g. sick leave), health, and functional outcomes in individuals with a RTC-related musculoskeletal injury, and explored what factors were associated with work-related outcomes. METHODS: Searches of seven databases were conducted up until 9/03/2023. Eligible interventions included adults with RTC-related musculoskeletal injuries, a comparison group, and a work-related outcome, and were in English...

Downregulation of miR-218 by nicotine promotes cell proliferation through targeting CDK6 in non-small cell lung cancer, by Zhen Liu, Cuiling Lu, Guanren Zhao, Xue Han, Kaisheng Dong, Chuanhai Wang, Jing-Zhi Guan, Zhongyuan Wang, J Cell Biochem. 2019; 120: 18370-18377: The above article, published online on 12 June 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.29148) has been retracted by agreement between the authors, the journal's Editor in Chief, Christian Behl, and Wiley Periodicals LLC...

This study takes Shanghai's restaurants as a case study of urban soft infrastructure, employing big data sets from third-party website platforms for multi-source data fusion, to deeply analyze the impact of urban land expansion and population dynamics on the availability, affordability, acceptability, and accessibility of restaurants. The case study reveals that, despite the Shanghai municipal authorities' focus on mitigating overcrowding in the central urban areas, soft infrastructure such as restaurants in new urban districts remains at a relative disadvantage...

Transcriptomic analyses across large scales of evolutionary distance have great potential to shed light on regulatory evolution but are complicated by difficulties in establishing orthology and limited availability of accessible software. We introduce here a method and a graphical user interface wrapper, called Annotator-RNAtor, for performing interspecies transcriptomic analysis and studying intragenus evolution. The pipeline uses third-party software to infer homologous genes in various species and highlight differences in the expression of the core-genes...

Retraction: "Small Interfering RNA Effectively Inhibits Protein Expression and Negative Strand RNA Synthesis From a Full-Length Hepatitis C Virus Clone" by Prabhu, R., Vittal, P., Yin, Q., Flemington, E., Garry, R., Robichaux, W.H. and Dash, S, J. Med. Virol 2005, 76: 511-519. The above article, published online on 23 June 2005, in Wiley Online Library (https://doi.org/10.1002/jmv.20391), has been retracted by agreement between the journal Editor-in-Chief, Shou-Jiang Gao, and Wiley Periodicals, LLC. The retraction has been agreed due to following publication concerns which were raised by third parties regarding Figure 3...

BACKGROUND: This study aimed to investigate the turnover intention among nurses in eastern China and explore the association between turnover intention and personal characteristics, family factors, and work-related factors. METHODS: A total of 2504 nurses participated in a cross-sectional survey administered in 26 hospitals in Eastern China from October to November 2017. In December 2021, a survey was conducted on nurses who resigned between December 2017 and November 2021...

The rapid growth of clean energy technologies is driving a rising demand for critical minerals. In 2022 at the 15th Conference of the Parties to the Convention on Biological Diversity (COP15), seven major economies formed an alliance to enhance the sustainability of mining these essential decarbonization minerals. However, there is a scarcity of studies assessing the threat of mining to global biodiversity. By integrating a global mining dataset with great ape density distribution, we estimated the number of African great apes that spatially coincided with industrial mining projects...

The literature has confirmed that when managers increase profits through earnings management, the readability of annual reports may be reduced Lo (2017), Ye (2018). Whether this conclusion is suitable for Chinese corporate social responsibility (CSR) reports, however, is still unclear. Based on the panel data of 5083 Chinese non-financial listed companies from 2010 to 2019, this paper adopts multiple linear regression to investigate the impact of earnings management on the readability of Chinese CSR reports...

Retraction: "MicroRNA-205 affects mouse granulosa cell apoptosis and estradiol synthesis by targeting CREB1," by Pengju Zhang, Jun Wang, Hongyan Lang, Weixia Wang, Xiaohui Liu, Haiyan Liu, Chengcheng Tan, Xintao Li, Yumin Zhao, Xinghong Wu, J Cell Biochem. 2018; 120: 8466-8474: The above article, published online on 16 December 2018 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.28133) has been retracted by agreement between the journal's Editor in Chief, Christian Behl, and Wiley Periodicals LLC...