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https://www.readbyqxmd.com/read/28920018/neonatal-sex-assignment-in-disorders-of-sex-development-a-philosophical-introspection
#1
REVIEW
V Raveenthiran
Management of ambiguous genitalia is highly controversial. This condition was known previously as intersex and presently as disorders of sex development (DSD). There is no consensus regarding the choice, timing and method of sex assignment in neonates with DSD. Consensus conferences could not unify the views of various stakeholders and third parties. This article philosophically examines the nature and origin of such controversies. Misconception, bias and conflicting priorities are identified as the three cardinal sources of controversies...
July 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28919591/the-establishment-and-operation-of-longjing-medical-college-the-history-of-longjing-medical-college-as-frontier-history-focusing-on-its-disconnection-and-continuity
#2
Mira Moon, Young-Jeon Shin
Longjing Medial College, established in Longjing, Yanbian, China on September 12, 1945, existed for about 1 year and 6 months until it was renamed as the Medical Department of Dongbei Junzheng Daxue Jilin Fenxiao in April 1947. However, there are only few records and studies on Longjing Medical College in Yanbian as well as in Korea. In order to fill the gap, this study attempted to restore the history of Longjing Medical College built in Yanbian, China immediately after the liberation. In particular, it analyzed how and why the Longjing Medical College was founded and operated, and which relations the college had with the post-war medical educational institutions, focusing on the 'disconnection' and 'continuity' in the historical sense...
August 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28919171/immunomodulatory-mechanisms-of-mesenchymal-stem-cells-and-their-therapeutic-applications
#3
Don K Lee, Sun U Song
In the recent years, many studies have shown that MSCs must be stimulated by pro-inflammatory cytokines or other immune mediators before they can modulate immune cells in inflamed and damaged tissues. MSCs appear to be involved in inducing several regulatory immune cells, such as Tregs, Bregs, and regulatory NK cells. This new immune milieu created by MSCs may establish a tolerogenic environment that leads to an optimal condition for the treatment of immune diseases. The mechanisms of MSC action to treat immune disorders need to be further investigated in more detail...
September 11, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28916004/telemedicine-for-child-collaborative-or-integrated-care
#4
REVIEW
Robert J Hilt
Telemedicine with child psychiatry specialists is a useful tool for collaborative and integrated care systems. This article reviews the workforce and care process rationale for using child psychiatric telemedicine for collaborative care, and discusses practical ways to address the technical challenges that arise when using telemedicine. Different systems of using telemedicine discussed include child psychiatry access programs, collaborative and integrated care use of telephone consultations, televideo consultations, and televideo care delivery...
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28905411/joint-arterial-input-function-and-tracker-kinetic-parameter-estimation-from-undersampled-dynamic-contrast-enhanced-mri-using-a-model-consistency-constraint
#5
Yi Guo, Sajan Goud Lingala, Yannick Bliesener, R Marc Lebel, Yinghua Zhu, Krishna S Nayak
PURPOSE: To develop and evaluate a model-based reconstruction framework for joint arterial input function (AIF) and kinetic parameter estimation from undersampled brain tumor dynamic contrast-enhanced MRI (DCE-MRI) data. METHODS: The proposed method poses the tracer-kinetic (TK) model as a model consistency constraint, enabling the flexible inclusion of different TK models and TK solvers, and the joint estimation of the AIF. The proposed method is evaluated using an anatomic realistic digital reference object (DRO), and nine retrospectively down-sampled brain tumor DCE-MRI datasets...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28901342/-the-recognition-of-peer-reviewers-activity-the-potential-promotion-of-a-virtuous-circle
#6
Alessandro Pierno, Robert Fruscio, Giacomo Bellani
Since several decades, peer review has become the standard to evaluate quality and priority of manuscripts submitted to scientific journals. During this process, manuscript is reviewed by scientists from the same field of the authors, with a competency on the topic of the manuscript (peer reviewers). Peer reviewers submit their comments to the journal editor, who then takes a decision on manuscript acceptance, need for revision of rejection. Several models for peer review exist, such as double-blind, single-blind, open, post publication...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28900753/fertility-treatment-for-the-transgender-community-a-public-opinion-study
#7
Randi H Goldman, Daniel J Kaser, Stacey A Missmer, Leslie V Farland, Scout, Rachel K Ashby, Elizabeth S Ginsburg
PURPOSE: The purposes of this study were to evaluate public opinion regarding fertility treatment and gamete cryopreservation for transgender individuals and identify how support varies by demographic characteristics. METHODS: This is a cross-sectional web-based survey study completed by a representative sample of 1111 US residents aged 18-75 years. Logistic regression was used to calculate odd ratios (ORs) and 95% confidence intervals (CIs) of support for/opposition to fertility treatments for transgender people by demographic characteristics, adjusting a priori for age, gender, race, and having a biological child...
September 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28889935/sociocultural-determinants-of-us-women-s-ethical-views-on-various-fertility-treatments
#8
Stephen C Collins, Esther Chan
Ethical concerns over treatments for infertility can discourage patients from pursuing fertility healthcare. This study aims to evaluate the sociocultural factors that influence the ethical views of reproductive-aged women regarding various fertility treatments. A publicly available cross-sectional survey of 4792 nationally representative US women aged 25-52 years was analysed to identify the frequency of ethical concerns over such interventions. Concerns were most common for treatments that increase the chance of twins (54%), followed by third-party reproductive strategies (48-51%), IVF (30%) and partner insemination (14%)...
August 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28885746/pseudo-extravasation-rate-constant-of-dynamic-susceptibility-contrast-mri-determined-from-pharmacokinetic-first-principles
#9
Xin Li, Csanad G Varallyay, Seymur Gahramanov, Rongwei Fu, William D Rooney, Edward A Neuwelt
Dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) is widely used to obtain informative perfusion imaging biomarkers, such as the relative cerebral blood volume (rCBV). The related post-processing software packages for DSC-MRI are available from major MRI instrument manufacturers and third-party vendors. One unique aspect of DSC-MRI with low-molecular-weight gadolinium (Gd)-based contrast reagent (CR) is that CR molecules leak into the interstitium space and therefore confound the DSC signal detected...
September 8, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28884585/analysis-of-the-cost-effectiveness-of-carbetocin-for-the-prevention-of-hemorrhage-following-cesarean-delivery-in-ecuador
#10
Aquiles Rodrigo Henríquez-Trujillo, Ruth Alicia Lucio-Romero, Kerlly Bermúdez-Gallegos
AIM: To compare the cost of carbetocin with that of oxytocin for the prevention and management of hemorrhage following cesarean delivery in Ecuador. MATERIALS & METHODS: We developed a decision tree based cost-effectiveness model to compare carbetocin with oxytocin in the prevention of hemorrhage following cesarean delivery in Ecuador. Our model was run from a third party payer perspective and was validated by local experts in the field. The efficacy of the interventions was determined based on a systematic review of the literature...
September 8, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28882727/newer-glycopeptide-antibiotics-for-treatment-of-complicated-skin-and-soft-tissue-infections-a-systematic-review-network-meta-analysis-and-cost-analysis
#11
REVIEW
Rajender Agarwal, Sarah M Bartsch, Brendan J Kelly, Malinda Prewitt, Yulun Liu, Yong Chen, Craig A Umscheid
OBJECTIVES: Skin and soft tissue infections (SSTIs) carry significant economic burden, as well as morbidity and mortality, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Several new MRSA-active antibiotics have been developed, including semisynthetic glycopeptides (telavancin, dalbavancin and oritavancin). Of these, dalbavancin and oritavancin offer extended dosing intervals. METHODS: We performed a systematic review, network meta-analysis and cost analysis to compare the newer glycopeptides to standard care and each other for the treatment of complicated SSTIs (cSSTI)...
September 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28881902/frequency-of-endoscopic-surveillance-for-barrett-s-esophagus-is-influenced-by-health-insurance-status-results-from-a-population-based-analysis
#12
A Faqih, K K Broman, L-C Huang, S E Phillips, M D Holzman, R A Pierce, B K Poulose, P S Yachimski
Factors that influence the frequency of surveillance endoscopy for nondysplastic Barrett's esophagus are not well understood. The objective of this study is to assess factors which influence the frequency of endoscopic surveillance for Barrett's esophagus, including health insurance/third-party payer status. Cases of nondysplastic Barrett's esophagus undergoing esophagogastroduodenoscopy with biopsy were identified using longitudinal data from the Healthcare Utilization Project database in 2005-2006 and followed through 2011...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28880050/effects-of-nanotechnologies-based-devices-on-postural-control-in-healthy-subjects
#13
Giovanna Malchiodi Albedi, Stefano Corna, Valentina Aspesi, Daniela Clerici, Cinzia Parisio, Jonathan Seitanidis, Nicola Cau, Luigia Brugliera, Paolo Capodaglio
BACKGROUND: The aim of the present preliminary randomized controlled study was to ascertain whether the use of newly developed nanotechnologies-based patches can influence posture control of healthy subjects. METHODS: Thirty healthy female subjects (age 39.4 years, BMI 22.74 kg/m2) were randomly assigned to two groups: one with active patches and a control group with sham patches. Two patches were applied with a tape: one on the subject's sternum and the other on the C7 apophysis...
September 5, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28878830/caesarean-birth-in-romania-safe-motherhood-between-ethical-medical-and-statistical-arguments
#14
Anca A Simionescu, Erika Marin
The number of caesarean sections increased significantly in Romania. In 2012, caesarean sections accounted for 41.2% of total births, according to a study of the Romanian National School for Public Health. This estimation is in agreement with the statistical data on caesarean sections recorded in one of the most important hospitals in Bucharest, Romania, Filantropia Hospital. Many factors have influenced the large number and sharply increasing trend of caesarean sections, from the historical ones, with roots in the communist regime, when abortions were outlawed, to current day doctors' medical practices and mothers' beliefs and fears related to the process of labor and the newborn's health...
January 2017: Mædica
https://www.readbyqxmd.com/read/28878770/changes-in-reactivity-in-vitro-of-cd4-cd25-and-cd4-cd25-t-cell-subsets-in-transplant-tolerance
#15
Bruce M Hall, Catherine M Robinson, Karren M Plain, Nirupama D Verma, Giang T Tran, Masaru Nomura, Nicole Carter, Rochelle Boyd, Suzanne J Hodgkinson
Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4(+)CD25(+) T cells, yet in many models, proliferation of CD4(+) T cells from hosts tolerant to specific-alloantigen in vitro is not impaired. To identify changes that may diagnose tolerance, changes in the patterns of proliferation of CD4(+), CD4(+)CD25(+), and CD4(+)CD25(-) T cells from DA rats tolerant to Piebald Virol Glaxo rat strain (PVG) cardiac allografts and from naïve DA rats were examined. Proliferation of CD4(+) T cells from both naïve and tolerant hosts was similar to both PVG and Lewis stimulator cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28877603/the-use-of-psychosocial-services-post-hand-and-upper-limb-injury-and-trauma-a-pilot-study
#16
Gregory Chown, Mary Beckwold, Heather Chernosky, Jonathan Lozoskie, Allison Yerkes
BACKGROUND: Research demonstrates that hand injuries may cause psychological difficulties. To enhance recovery, therapists must provide appropriate referrals. The purpose of this study was to explore the use of psychosocial services by occupational therapists (OTs) and certified hand therapists (CHTs) post hand and upper limb injury or trauma. METHODS: A quantitative survey design was implemented using a self-made questionnaire, which consisted of questions regarding demographic information, types and frequency of hand and upper limb injuries, psychiatric diagnoses, frequency of psychosocial service referrals, frames of references used, types of psychosocial assessments and interventions employed, and barriers to psychosocial services...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28869031/cost-analysis-of-bariatric-surgery-in-denmark-made-with-a-decision-analytic-model
#17
Oleg Borisenko, Vasily Lukyanov, Søren Paaske Johnsen, Peter Funch-Jensen
INTRODUCTION: Bariatric surgery offers effective obesity treatment. The aim of this study was to evaluate the cost-effectiveness of bariatric surgery in Denmark from a third-party payer perspective in the mid- (ten years) and long-term (lifetime). METHODS: A state-transition Markov model was developed in which patients may experience surgery, post-surgery complications, diabetes mellitus type 2, cardiovascular diseases or die. Transition probabilities, costs and utilities were informed by the literature...
August 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28863317/mediator-or-moderator-the-role-of-mindfulness-in-the-association-between-child-behavior-problems-and-parental-stress
#18
Tim Oi Chan, Shui-Fong Lam
BACKGROUND: Raising a child with intellectual disability (ID) may be stressful for parents. Previous studies have suggested the mediating role of mindfulness in the association between child behavior problems and parental stress. AIMS: The present study examined whether this mediating role is a result of parents' self-report bias. It also explored whether mindfulness has a moderating role instead when child behavior problems are reported by teachers. METHODS: In a questionnaire survey, 271 Chinese parents of children with ID in 6 Hong Kong special schools reported their levels of stress and mindfulness, as well as their children's behavior problems...
August 29, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28862661/the-effect-of-taichi-practice-on-attenuating-bone-mineral-density-loss-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
REVIEW
Liye Zou, Chaoyi Wang, Kevin Chen, Yankai Shu, Xiaoan Chen, Lin Luo, Xitang Zhao
Objective: The purpose of this study was to determine the effects of practicing Taichi on attenuating bone mineral density (BMD) loss. Methods: Both electronic and manual searches were performed for randomized controlled trials (RCTs) examining Taichi for bone health. Two review authors independently performed study selection and data extraction according to inclusion criteria. A third party (Lin Luo) emerged to discuss with the two review authors and resolve a disagreement. Results: Twenty RCTs were found to meet the inclusion criteria and used for meta-analysis with a total effective sample of 1604...
September 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28858770/the-early-emergence-of-sociomoral-evaluation-infants-prefer-prosocial-others
#20
REVIEW
Julia W Van de Vondervoort, Jane Kiley Hamlin
Humans readily evaluate third-parties' prosocial and antisocial acts. Recent evidence reveals that this tendency emerges early in development-even preverbal infants selectively approach prosocial others and avoid antisocial ones. Rather than reflecting attraction toward or away from low-level characteristics of the displays or simple behavioral rules, infants are sensitive to characteristics of both the agents and recipients of prosocial and antisocial acts. Specifically, infants' preferences require that the recipients of positive and negative acts be social agents with clear unfulfilled goals, who have not previously harmed others...
August 12, 2017: Current Opinion in Psychology
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