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https://www.readbyqxmd.com/read/28306738/comparative-evaluation-of-the-minimally-invasive-karyotyping-mink-algorithm-for-non-invasive-prenatal-testing
#1
Tianjiao Chu, Patricia A Shaw, Suveyda Yeniterzi, Mary Dunkel, Aleksander Rajkovic, W Allen Hogge, Kimberly D Bunce, David G Peters
Minimally Invasive Karyotyping (MINK) was communicated in 2009 as a novel method for the non-invasive detection of fetal copy number anomalies in maternal plasma DNA. The original manuscript illustrated the potential of MINK using a model system in which fragmented genomic DNA obtained from a trisomy 21 male individual was mixed with that of his karyotypically normal mother at dilutions representing fetal fractions found in maternal plasma. Although it has been previously shown that MINK is able to non-invasively detect fetal microdeletions, its utility for aneuploidy detection in maternal plasma has not previously been demonstrated...
2017: PloS One
https://www.readbyqxmd.com/read/28301397/the-michigan-trauma-quality-improvement-program-results-from-a-collaborative-quality-initiative
#2
Mark R Hemmila, Jill L Jakubus, Anne H Cain-Nielsen, John P Kepros, Wayne E Vander Kolk, Wendy L Wahl, Judy N Mikhail
BACKGROUND: American College of Surgeons verified trauma centers and a third party payer within the state of Michigan built a regional collaborative quality initiative (CQI). The Michigan Trauma Quality Improvement Program began as a pilot in 2008 and expanded to a formal program in 2011. Here, we examine the performance of the collaborative over time with regard to patient outcomes, resource utilization, and process measures. METHODS: Data from the initial 23 hospitals that joined the CQI in 2011 were analyzed...
March 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28301365/preserving-the-legitimacy-of-board-certification
#3
Michael S Hanemann, Holly C Wall, John A Dean
OBJECTIVES: The aims of this discussion were to inform the medical community about the American Board of Cosmetic Surgery's ongoing attempts in Louisiana to achieve equivalency to American Board of Medical Specialties (ABMS) member boards so that its diplomates may use the term "board certified" in advertising and to ensure public safety by upholding the standards for medical board certification. BACKGROUND: In 2011, Louisiana passed a truth in medical advertising law, which was intended to protect the public by prohibiting the use of the term "board certified" by improperly credentialed physicians...
March 16, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28301363/the-plastic-surgeon-as-employee-a-pilot-survey-of-the-california-society-of-plastic-surgeons
#4
Nirav Bipin Patel, Demetrius M Coombs, Mena Arsalai, Chin-Shang Li, Yu Liu, Thomas R Stevenson, Lee L Q Pu
INTRODUCTION: Plastic surgeons endure years of training yet remain poorly equipped to negotiate first employment contracts. Our aims were to evaluate typical plastic surgeon employment contracts and assess contract comprehensiveness. We sought elements that should be included to better preserve varied interests. METHODS: A brief, anonymous, e-mailed survey was sent to California Society of Plastic Surgeons members and responses collected over 2 months. We collected information such as years in practice, geographic area, types of practices and number of surgeons within them, and legal standing of partnerships...
March 16, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28296983/comparing-the-fracture-resistance-of-alternatively-engineered-zirconia-abutments-with-original-equipment-manufactured-abutments-with-different-implant-connection-designs
#5
Joseph M Jarman, Techkouhie Hamalian, Anthony P Randi
PURPOSE: Aftermarket computer-aided design/computer-assisted manufacture (CAD/CAM) milled zirconia (Zr) abutments were recently introduced with minimal independent research regarding their fracture resistance. Third-party manufacturers often alter the original equipment manufacturers' (OEM) design with unknown effects on fracture resistance. These alterations include elimination of the titanium insert with subsequent introduction of Zr into the implant, changes to connection designs and shapes, and/or alterations to prosthetic screw design...
March 15, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28294209/tooth-supported-surgical-guides-for-guided-placement-of-%C3%A2-single-tooth-implants
#6
Andreas Kurbad
Computer-assisted technologies open up new possibilities for significantly improving the planning and realization of implant-supported dental restorations. Three-dimensional (3D) data acquired with an intraoral sensor can be merged with comparable data acquired by various radiographic imaging techniques. Implant planning with this type of support can generate data for the manufacture of surgical guides for dental implants. The guides can then be fabricated either by a third-party provider or by the implantologist directly, by using time- and cost-saving in-office systems...
2017: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28291924/a-method-for-confirming-a-third-party-assay-of-i-125-seeds-used-for-prostate-implants
#7
John S Muryn, D Allan Wilkinson
The purpose of this work is to describe a method and apparatus that can be used to confirm the source strength of a large number of I-125 seeds while maintaining sterility, accuracy, reproducibility, and time efficiency. Source strengths ranging from 0.395 to 0.504 U/seed were available for this study. Three different seed configurations were measured: loose, linked, and loaded needles. A third-party 10% assay (NIST traceable) was provided. A custom stand was built out of aluminum to hold an exposure meter [Inovision (Fluke) 451P pressurized ion chamber] at 25 cm above the I-125 sources to measure the exposure rate...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28289548/the-comparative-effectiveness-and-cost-effectiveness-of-ranibizumab-for-neovascular-macular-degeneration-revisited
#8
Gary C Brown, Melissa M Brown, Heidi B Lieske, Adam Turpcu, Yamina Rajput
BACKGROUND: To compare a near decade of follow-up, newer control cohort data, use of both the societal and third party insurer cost perspectives, and integration of unilateral/bilateral therapy on the comparative effectiveness and cost-effectiveness of intravitreal ranibizumab therapy for neovascular, age-related macular degeneration (AMD). METHODS: Value-Based Medicine(®), 12-year, combined-eye model, cost-utility analysis employing MARINA and HORIZON clinical trial data...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28288475/cochlear-implantation-in-children-with-congenital-single-sided-deafness
#9
Jan Peter Thomas, Katrin Neumann, Stefan Dazert, Christiane Voelter
OBJECTIVE: To determine audiological and clinical results of cochlear implantation in children with congenital single sided deafness (SSD), with an emphasis on children implanted before and after 6 years of age. STUDY DESIGN: Retrospective study. SETTING: Tertiary referral center. SUBJECTS: Twenty one children with congenital SSD who were implanted aged 10 months to 11;3 years. INTERVENTION: Unilateral cochlear implantation...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28286594/locking-it-down-the-privacy-and-security-of-mobile-medication-apps
#10
Kelly Grindrod, Jonathan Boersema, Khrystine Waked, Vivian Smith, Jilan Yang, Catherine Gebotys
OBJECTIVE: To explore the privacy and security of free medication applications (apps) available to Canadian consumers. METHODS: The authors searched the Canadian iTunes store for iOS apps and the Canadian Google Play store for Android apps related to medication use and management. Using an Apple iPad Air 2 and a Google Nexus 7 tablet, 2 reviewers generated a list of apps that met the following inclusion criteria: free, available in English, intended for consumer use and related to medication management...
January 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28285046/children-use-partial-resource-sharing-as-a-cue-to-friendship
#11
Zoe Liberman, Alex Shaw
Resource sharing is an important aspect of human society, and how resources are distributed can provide people with crucial information about social structure. Indeed, a recent partiality account of resource distribution suggested that people may use unequal partial resource distributions to make inferences about a distributor's social affiliations. To empirically test this suggestion derived from the theoretical argument of the partiality account, we presented 4- to 9-year-old children with distributors who gave out resources unequally using either a partial procedure (intentionally choosing which recipient would get more) or an impartial procedure (rolling a die to determine which recipient would get more) and asked children to make judgments about whom the distributor was better friends with...
March 9, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28284916/infusion-of-mesenchymal-stromal-cells-after-deceased-liver-transplantation-a-phase-i-ii-open-label-clinical-study
#12
Olivier Detry, Morgan Vandermeulen, Marie-Hélène Delbouille, Joan Somja, Noella Bletard, Alexandra Briquet, Chantal Lechanteur, Olivier Giet, Etienne Baudoux, Muriel Hannon, Frederic Baron, Yves Beguin
BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the feasibility, safety and tolerability of a single infusion of MSCs in liver transplant recipients. METHODS: Ten liver transplant recipients under standard immunosuppression received 1.5-3x10(6)/kg third-party unrelated MSCs on post-operative day 3±2, and were prospectively compared to a control group of 10 liver transplant recipients...
March 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28281785/disclosing-mental-illness-information-to-a-friend-exploring-how-the-disclosure-decision-making-model-informs-strategy-selection
#13
Maria K Venetis, Skye Chernichky-Karcher, Patricia E Gettings
Within the context of mental illness disclosure between friends, this study tested the disclosure decision-making model (DD-MM; Greene, 2009) to comprehensively investigate factors that predict disclosure enactment strategies. The DD-MM describes how individuals determine whether they will reveal or conceal non-visible health information. Processes of revealing, called disclosures, take various forms including preparation and rehearsal, directness, third-party disclosure, incremental disclosures, entrapment, and indirect mediums (Afifi & Steuber, 2009)...
March 10, 2017: Health Communication
https://www.readbyqxmd.com/read/28275937/-re-disclosing-physician-financial-interests-rebuilding-trust-or-making-unreasonable-burdens-on-physicians
#14
Daniel Sperling
Recent professional guidelines published by the General Medical Council instruct physicians in the UK to be honest and open in any financial agreements they have with their patients and third parties. These guidelines are in addition to a European policy addressing disclosure of physician financial interests in the industry. Similarly, In the US, a national open payments program as well as Federal regulations under the Affordable Care Act re-address the issue of disclosure of physician financial interests in America...
March 8, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28274267/controlling-corporate-influence-in-health-policy-making-an-assessment-of-the-implementation-of-article-5-3-of-the-world-health-organization-framework-convention-on-tobacco-control
#15
Gary Jonas Fooks, Julia Smith, Kelley Lee, Chris Holden
BACKGROUND: The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) stands to significantly reduce tobacco-related mortality by accelerating the introduction of evidence-based tobacco control measures. However, the extent to which States Parties have implemented the Convention varies considerably. Article 5.3 of the FCTC, is intended to insulate policy-making from the tobacco industry's political influence, and aims to address barriers to strong implementation of the Convention associated with tobacco industry political activity...
March 8, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28273330/interventions-for-hereditary-haemochromatosis-an-attempted-network-meta-analysis
#16
REVIEW
Elena Buzzetti, Maria Kalafateli, Douglas Thorburn, Brian R Davidson, Emmanuel Tsochatzis, Kurinchi Selvan Gurusamy
BACKGROUND: Hereditary haemochromatosis is a genetic disorder related to proteins involved in iron transport, resulting in iron load and deposition of iron in various tissues of the body. This iron overload leads to complications including liver cirrhosis (and related complications such as liver failure and hepatocellular carcinoma), cardiac failure, cardiac arrhythmias, impotence, diabetes, arthritis, and skin pigmentation. Phlebotomy (venesection or 'blood letting') is the currently recommended treatment for hereditary haemochromatosis...
March 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28272533/paternity-testing-under-the-cloak-of-recreational-genetics
#17
Nathalie Moray, Katherina E Pink, Pascal Borry, Maarten Hd Larmuseau
Direct-to-consumer (DTC) internet companies are selling widely advertised and highly popular genetic ancestry tests to the broad public. These tests are often classified as falling within the scope of so-called 'recreational genetics', but little is known about the impact of using these services. In this study, a particular focus is whether minors (and under what conditions) should be able to participate in the use of these DTC tests. Current ancestry tests are easily able to reveal whether participants are related and can, therefore, also reveal misattributed paternity, with implications for the minors and adults involved in the testing...
March 8, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28271822/crystal-diagnostics-xpress-s-kit-for-the-rapid-detection-of-salmonella-spp-in-selected-food-matrixes
#18
Brian Bullard, Curtis H Stumpf, Weidong Zhao, Stephanie Kuzenko, Gary Niehaus
The Crystal Diagnostics (CDx) Xpress S Kit is a rapid- screening assay for <i>Salmonella</i> spp. in whole raw tomatoes, whole chicken c`arcasses, raw ground beef, raw beef trim, and whole liquid pasteurized eggs with citric acid when present at levels of 1 CFU/portion size. The Xpress S system comprises an automatic CDx Xpress Reader and a single-use CDx BioCassette that incorporates antibody-coupled microspheres and liquid crystal for the selective identification of the intended microbe. In internal evaluations, the CDx Xpress S Kit detected all 142 <i>Salmonella</i> strains tested, including non-<i>enterica</i> subspecies, and excluded all non-<i>Salmonella</i> species assayed...
March 7, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28266742/shadow-analysis-via-the-c-k-visioline-a-technical-note
#19
T Houser, C Zerweck, G Grove, R Wickett
BACKGROUND/PURPOSE: This research investigated the ability of shadow analysis (via the Courage + Khazaka Visioline and Image Pro Premiere 9.0 software) to accurately assess the differences in skin topography associated with photo aging. METHODS: Analyses were performed on impressions collected from a microfinish comparator scale (GAR Electroforming) as well a series of impressions collected from the crow's feet region of 9 women who represent each point on the Zerweck Crow's Feet classification scale...
March 7, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28263281/-where-s-my-choice-an-examination-of-veteran-and-provider-experiences-with-hepatitis-c-treatment-through-the-veteran-affairs-choice-program
#20
Jack Tsai, Vera Yakovchenko, Natalie Jones, Avy Skolnik, Amanda Noska, Allen L Gifford, D Keith McInnes
BACKGROUND: The Department of Veterans Affairs (VA) is the country's largest provider for chronic hepatitis C virus (HCV) infection. The VA created the Choice Program, which allows eligible veterans to seek care from community providers, who are reimbursed by the VA. OBJECTIVES: This study aimed to examine perspectives and experiences with the VA Choice Program among veteran patients and their HCV providers. RESEARCH DESIGN: Qualitative study based on semistructured interviews with veteran patients and VA providers...
March 3, 2017: Medical Care
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