keyword
https://read.qxmd.com/read/38534240/highly-sensitive-and-wide-range-detection-of-thiabendazole-via-surface-enhanced-raman-scattering-using-bimetallic-nanoparticle-functionalized-nanopillars
#1
JOURNAL ARTICLE
Hyunjun Park, Gayoung Kim, Woochang Kim, Eugene Park, Joohyung Park, Jinsung Park
Thiabendazole (TBZ) is a benzimidazole; owing to its potent antimicrobial properties, TBZ is extensively employed in agriculture as a fungicide and pesticide. However, TBZ poses environmental risks, and excessive exposure to TBZ through various leakage pathways can cause adverse effects in humans. Therefore, a method must be developed for early and sensitive detection of TBZ over a range of concentrations, considering both human and environmental perspectives. In this study, we used silver nanopillar structures (SNPis) and Au@Ag bimetallic nanoparticles (BNPs) to fabricate a BNP@SNPi substrate...
March 4, 2024: Biosensors
https://read.qxmd.com/read/38530399/improving-predictions-of-compound-amenability-for-liquid-chromatography-mass-spectrometry-to-enhance-non-targeted-analysis
#2
JOURNAL ARTICLE
Nathaniel Charest, Charles N Lowe, Christian Ramsland, Brian Meyer, Vicente Samano, Antony J Williams
Mass-spectrometry-based non-targeted analysis (NTA), in which mass spectrometric signals are assigned chemical identities based on a systematic collation of evidence, is a growing area of interest for toxicological risk assessment. Successful NTA results in better identification of potentially hazardous pollutants within the environment, facilitating the development of targeted analytical strategies to best characterize risks to human and ecological health. A supporting component of the NTA process involves assessing whether suspected chemicals are amenable to the mass spectrometric method, which is necessary in order to assign an observed signal to the chemical structure...
March 26, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38530234/development-and-validation-of-bioanalytical-methods-to-support-clinical-study-of-disitamab-vedotin
#3
JOURNAL ARTICLE
Baiyang Wu, Qiaoning Li, Ling Wang, Fang Chen, Jing Jiang
Disitamab vedotin (RC48), a humanized anti-HER2 antibody conjugated with monomethyl auristatin E (MMAE), is the first antibody-drug conjugate in China with an approved biological license application. A bioanalytical method was established for three analytes (total antibody, conjugate antibody and free payload) to help characterize their pharmacokinetic behavior in clinical settings. The bioanalytical methods were validated according to M10 guidance. Electrochemiluminescence assay methods were used for the quantitative measurement of total antibody and conjugated antibody in human serum...
March 26, 2024: Bioanalysis
https://read.qxmd.com/read/38530226/an-interview-with-bioanalysis-speaking-with-the-2023-reid-bursary-award-winners-part-2
#4
JOURNAL ARTICLE
Olga Begou, Artemis Lioupi, Georgina Page, Shwan Ahmed, Svenja Stiltz, Rebecca Dowell, Jack Lodge
The 25th edition of the International Reid Bioanalytical Forum (REID) was held at the Cambridge Belfry (Cambourne, UK) between 4 and 7 September 2023 and hosted approximately 100 delegates, the majority of whom were attending the event for their first time. REID encourages early-career researchers to present their work and have a bursary program to help provide them support. At the 2023 event, REID welcomed 15 bursary winners to provide them with the opportunity to participate in their first international meeting, network with their peers and make their first oral, or poster presentation...
March 26, 2024: Bioanalysis
https://read.qxmd.com/read/38530219/the-challenges-for-implementing-good-clinical-practices-in-the-bioanalytical-laboratory-a-discussion-paper-from-the-european-bioanalysis-forum
#5
JOURNAL ARTICLE
Philip Timmerman, Tsvetelina Ivanova, Cecilia Arfvidsson, Matthew Barfield, Floris Bove, Lea Dalby Brown, Jo Goodman, Stuart McDougall, Lee Monk, Steve White
This manuscript reports back from the discussion in the European Bioanalysis Forum community on the challenges observed when implementing Good Clinical Practices in the bioanalytical laboratory. It is not intended to challenge any regulatory requirements but to open a discussion on where the bioanalytical community sees ambiguities on implementing Good Clinical Practices or areas where expectations are either felt not being owned by Bioanalysis or where Good Clinical Practices requirements are at risk of getting contaminated with requirements originating from Good Laboratory Practices...
March 26, 2024: Bioanalysis
https://read.qxmd.com/read/38530141/mn-2-mediated-modulation-of-pfago-activity-for-biosensing
#6
JOURNAL ARTICLE
Ruijie Fu, Jinjie Hou, Zexiang Wang, Yunlei Xianyu
Argonaute (Ago) as a powerful enzyme has provided new insights into biosensing due to its programmability, high sensitivity, and user-friendly operation. However, current strategies mainly rely on phosphorylated guide DNA to modulate the cleavage activity of Ago, which are limited in versatility and simplicity. Herein, we reported Mn2+ -enhanced cleavage activity of Ago and employed Mn ions with variable valence to regulate the activity of Pyrococcus furiosus Ago (PfAgo) for biosensing applications. The conversion of Mn ions with different valence states through MnO2 nanoflowers enables the sensitive detection of ascorbic acid, alkaline phosphatase, and arsenic with limits of detection of 2...
March 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38529928/therapeutic-drug-monitoring-of-vancomycin-in-surgical-patients-through-a-validated-hplc-method
#7
JOURNAL ARTICLE
Muhammad Noman Akram, Muhammad Imran Khokhar, Mateen Abbas, Muhammad Khurram Waqas, Mian Waqar Mustafa, Abdulhakeem S Alamri, Majid Alhomrani, Walaa F Alsanie, Muhammad Usman
BACKGROUND: Vancomycin is being used for the treatment of a variety of infections caused by methicillin resistant Staphylococcus aureus and methicillin susceptible Staphylococcus aureus . Therapeutic drug monitoring (TDM) is highly recommended for ensuring the safe and effective therapy with vancomycin. A reliable and cost-effective bioanalytical method is required for TDM as well as pharmacokinetic studies of vancomycin. MATERIALS AND METHODS: A selective, sensitive, and cost effective HPLC method was developed and validated for quantification of vancomycin concentrations in human plasma...
March 26, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38526017/an-interview-with-bioanalysis-speaking-with-the-2023-international-reid-bioanalytical-forum-bursary-award-winners-part-1
#8
JOURNAL ARTICLE
Esther May, Sam Morris, Afeefa Kiran Chaudhary, Sahand Shams, Thanyaporn Tengsuttiwat, Rajit Kolamunne, Jack Lodge
No abstract text is available yet for this article.
April 2024: Bioanalysis
https://read.qxmd.com/read/38523160/electrochemical-microfluidic-sensing-platforms-for-biosecurity-analysis
#9
REVIEW
Zhaowei Guan, Quanyi Liu, Chong-Bo Ma, Yan Du
Biosecurity encompasses the health and safety of humans, animals, plants, and the environment. In this article, "biosecurity" is defined as encompassing the comprehensive aspects of human, animal, plant, and environmental safety. Reliable biosecurity testing technology is the key point for effectively assessing biosecurity risks and ensuring biosecurity. Therefore, it is crucial to develop excellent detection technologies to detect risk factors that can affect biosecurity. An electrochemical microfluidic biosensing platform integrates fluid control, target recognition, signal transduction, and output and incorporates the advantages of electrochemical analysis technology and microfluidic technology...
March 25, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38523159/presenting-the-2023-awardees-of-robert-kellner-and-dac-euchems-lectures-congratulations-to-abc-s-chair-editor-antje-baeumner-and-long-term-abc-supporter-dami%C3%A3-barcel%C3%A3
#10
EDITORIAL
Nicola Oberbeckmann-Winter
No abstract text is available yet for this article.
March 24, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38523158/development-of-a-rapid-fire-drug-screening-method-by-probe-electrospray-ionization-tandem-mass-spectrometry-for-human-urine-radpi-u
#11
JOURNAL ARTICLE
Kazuaki Hisatsune, Tasuku Murata, Masaru Taniguchi, Tomomi Asano, Koretsugu Ogata, Akira Iguchi, Kei Zaitsu
Drug screening tests are mandatory in the search for drugs in forensic biological samples, and immunological methods and mass spectrometry (e.g., gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry) are commonly used for that purpose. However, these methods have some drawbacks, and developing new screening methods is required. In this study, we develop a rapid-fire drug screening method by probe electrospray ionization tandem mass spectrometry (PESI-MS/MS), which is an ambient ionization mass spectrometry method, for human urine, named RaDPi-U...
March 25, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38520676/plasma-instead-of-serum-avoids-critical-confounding-of-clinical-metabolomics-studies-by-platelets
#12
JOURNAL ARTICLE
Gerhard Hagn, Samuel M Meier-Menches, Günter Plessl-Walder, Gaurav Mitra, Thomas Mohr, Karin Preindl, Andreas Schlatter, Doreen Schmidl, Christopher Gerner, Gerhard Garhöfer, Andrea Bileck
Metabolomics is an emerging and powerful bioanalytical method supporting clinical investigations. Serum and plasma are commonly used without rational prioritization. Serum is collected after blood coagulation, a complex biochemical process involving active platelet metabolism. This may affect the metabolome and increase the variance, as platelet counts and function may vary substantially in individuals. A multiomics approach systematically investigating the suitability of serum and plasma for clinical studies demonstrated that metabolites correlated well ( n = 461, R 2 = 0...
March 23, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38520589/inorganic-arsenic-in-seaweed-a-fast-hplc-icp-ms-method-without-coelution-of-arsenosugars
#13
JOURNAL ARTICLE
Rebecca Sim, Marta Weyer, Ásta H Pétursdóttir
Seaweed is becoming increasingly popular in the Western diet as consumers opt for more sustainable food sources. However, seaweed is known to accumulate high levels of arsenic-which may be in the form of carcinogenic inorganic arsenic (iAs). Here we propose a fast method for the routine measurement of iAs in seaweed using HPLC-ICP-MS without coelution of arsenosugars that may complicate quantification. The developed method was optimised using design of experiments (DOE) and tested on a range of reference materials including TORT-3 (0...
March 23, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38520588/the-tightest-self-assembled-ruthenium-metal-organic-framework-combined-with-proximity-hybridization-for-ultrasensitive-electrochemiluminescence-analysis-of-paraquat
#14
JOURNAL ARTICLE
Ling Qin, Wenbin Liang, Weiguo Yang, Shenghan Tang, Ruo Yuan, Jun Yang, Yan Li, Shanshan Hu
Metal-organic frameworks (MOFs), as porous materials, have great potential for exploring high-performance electrochemiluminescence (ECL) probes. However, the constrained applicability of MOFs in the realm of ECL biosensing is primarily attributed to their inadequate water stability, which consequently impairs the overall ECL efficiency. Herein, we developed a competitive ECL biosensor based on a novel tightest structural ruthenium-based organic framework emitter combining the proximity hybridization-induced catalytic hairpin assembly (CHA) strategy and the quenching effect between the Ru-MOF and ferrocene for detecting paraquat (PQ)...
March 23, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38517490/advanced-tools-for-molecular-characterization-of-bio-based-and-biodegradable-polymers
#15
REVIEW
Ndumiso Sibanda, Helen Pfukwa, Paul Eselem Bungu, Harald Pasch
Bio-based and biodegradable materials play a vital role in a sustainable and green economy. These materials must exhibit properties that are similar to or better than the properties of oil- or coal-based materials and require sophisticated synthesis technologies and detailed knowledge of structure-property correlations. For comprehensive molecular structure elucidation, advanced analytical methods, including coupled and hyphenated techniques that combine advanced fractionation and information-rich spectroscopic detectors, are an indispensable tool...
March 22, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38516978/silver-induced-chirality-controlled-spin-filtration-observed-in-ss-dna-functionalized-with-mos2
#16
JOURNAL ARTICLE
Abhinandan Kumar, Subrata Majumder
Chiral molecules can exhibit strong spin-orbit coupling, which can result in a large spin polarization. This is due to the fact that the energy levels of the electrons in a chiral molecule are strongly influenced by the chiral structure of the molecule, which can result in the separation of the energy levels for electrons with different spin orientations. We report a controlled spin-selective transmission of electrons through 20 base-paired poly-cytosine molecules functionalized with MoS2 flakes on ITO glass via the quantum mechanical tunneling effect...
March 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38516084/topological-effect-of-an-intramolecular-split-g-quadruplex-on-thioflavin-t-binding-and-fluorescence-light-up
#17
JOURNAL ARTICLE
Mengmeng Lv, Jiangtao Ren, Erkang Wang
In this work, the topological effect on binding interaction between a G-quadruplex and thioflavin T (ThT) ligand was systematically investigated on a platform of an intramolecular split G-quadruplex (Intra-SG). Distinct fluorescence changes from ThT were presented in the presence of distinct split modes of Intra-SG structures and an intriguing phenomenon of target-induced fluorescence light-up occurred for split modes 2 : 10, 5 : 7 and 8 : 4. It was validated that hybridization between the Intra-SG spacer and target did not unfold the G-quadruplex, but facilitated the ThT binding...
March 20, 2024: Chemical Science
https://read.qxmd.com/read/38514583/simultaneous-determination-of-diquat-paraquat-glufosinate-and-glyphosate-in-plasma-by-liquid-chromatography-tandem-mass-spectrometry-from-method-development-to-clinical-application
#18
JOURNAL ARTICLE
Maozhu Liu, Fei Fan, Jing Zhang, Shiyong Fang, Yangjuan Bai, Yamei Li, Yuangao Zou, Yunfei An, Xinhua Dai
Diquat (DQ), paraquat (PQ), glufosinate (GLU), and glyphosate (GLYP) are commonly used herbicides that have been confirmed to be toxic to humans. Rapid and accurate measurements of these toxicants in clinical practice are beneficial for the correct diagnosis and timely treatment of herbicide-poisoned patients. The present study aimed to establish an efficient, convenient, and reliable method to achieve the simultaneous quantification of DQ, PQ, GLU, and GLYP in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS) without using derivatization or ion-pairing reagents...
March 22, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38512384/ratiometric-electrochemiluminescence-sensing-and-intracellular-imaging-of-clo-via-resonance-energy-transfer
#19
JOURNAL ARTICLE
Cheng Ma, Yujing Zhu, Zhichen Zhang, Xuan Chen, Zhengping Ji, Lu-Nan Zhang, Qin Xu
Electrochemiluminescence resonance energy transfer (ECL-RET) is a versatile signal transduction strategy widely used in the fabrication of chem/biosensors. However, this technique has not yet been applied in visualized imaging analysis of intracellular species due to the insulating nature of the cell membrane. Here, we construct a ratiometric ECL-RET analytical method for hypochlorite ions (ClO- ) by ECL luminophore, with a luminol derivative (L-012) as the donor and a fluorescence probe (fluorescein hydrazide) as the acceptor...
March 21, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38509355/correction-to-a-new-methodology-to-reveal-potential-nucleic-acid-modifications-associated-with-the-risk-of-endometrial-cancer-through-dispersive-solid%C3%A2-phase-extraction-coupled-with-uhplc%C3%A2-qe%C3%A2-orbitrap%C3%A2-ms-ms-and-hplc-uv
#20
Huanhuan Zhao, Xiaoguang Zhang, Lujie Zuo, Li Li, Hongfang Yang, Mengyu Zhang, Na Wang, Qingzhong Jia, Yan Liu
No abstract text is available yet for this article.
March 21, 2024: Analytical and Bioanalytical Chemistry
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