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https://www.readbyqxmd.com/read/29777832/novel-cysteine-and-albumin-adduct-biomarkers-to-prove-human-poisoning-with-the-pesticide-oxydemeton-s-methyl
#1
Harald John, Markus Siegert, Florian Eyer, Franz Worek, Horst Thiermann, Andreas Kranawetvogl
We herein report on the forensic analysis of plasma samples to prove human poisoning with oxydemeton-S-methyl (ODM), S-(2-(ethylsulfinyl)ethyl)-O,O-dimethyl phosphorothioate. This organophosphorus pesticide is the active ingredient of Metasystox® , that was swallowed by a 77-year-old woman to commit suicide. ODM belongs to the class of dimethyl phosphoryl (DMP) pesticides, contains a 2-(ethylsulfinyl)ethanethiol (ESOET) leaving group and undergoes adduct formation with endogenous molecules as elaborated herein with human serum exposed to pesticides in vitro...
May 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29772250/development-and-validation-of-a-novel-semi-homogenous-clinical-assay-for-quantitation-of-ranibizumab-in-human-serum
#2
John Lowe, Eric Wakshull, Theresa Shek, Anan Chuntharapai, Rebecca Elliott, Jeriza Rusit, Mauricio Maia
Ranibizumab (Lucentis®), a humanized antigen-binding fragment (Fab) monoclonal antibody that blocks VEGF-A activity is currently approved for the treatment of several retinal degenerative diseases. The assessment of drug pharmacokinetics (PK) is essential for evaluating exposure as it relates to drug safety and efficacy. For drugs administered intravitreally, systemic drug levels during the course of clinical studies are typically 100 to 1000-fold lower than those of similar therapeutics dosed intravenously, posing a significant bioanalytical challenge for PK measurements...
May 14, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29771154/bioanalytical-and-methodological-challenges-in-the-evaluation-of-fetal-cannabis-exposure
#3
Jefferson Pereira Silva, Mauricio Yonamine
No abstract text is available yet for this article.
May 17, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29768033/endogenous-probes-for-human-liver-organic-anion-transporting-polypeptides-the-intersection-of-bioanalytical-and-adme-science
#4
A David Rodrigues
No abstract text is available yet for this article.
May 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29763745/analysis-of-malondialdehyde-in-human-plasma-samples-through-derivatization-with-2-4-dinitrophenylhydrazine-by-ultrasound-assisted-dispersive-liquid-liquid-microextraction-gc-fid-approach
#5
Reyhane Malaei, Amir M Ramezani, Ghodratollah Absalan
A sensitive and reliable ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) procedure was developed and validated for extraction and analysis of malondialdehyde (MDA) as an important lipids-peroxidation biomarker in human plasma. In this methodology, to achieve an applicable extraction procedure, the whole optimization processes were performed in human plasma. To convert MDA into readily extractable species, it was derivatized to hydrazone structure-base by 2,4-dinitrophenylhydrazine (DNPH) at 40 °C within 60 min...
May 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29751688/cmos-compatible-silicon-nanowire-field-effect-transistor-biosensor-technology-development-toward-commercialization
#6
REVIEW
Duy Phu Tran, Thuy Thi Thanh Pham, Bernhard Wolfrum, Andreas Offenhäusser, Benjamin Thierry
Owing to their two-dimensional confinements, silicon nanowires display remarkable optical, magnetic, and electronic properties. Of special interest has been the development of advanced biosensing approaches based on the field effect associated with silicon nanowires (SiNWs). Recent advancements in top-down fabrication technologies have paved the way to large scale production of high density and quality arrays of SiNW field effect transistor (FETs), a critical step towards their integration in real-life biosensing applications...
May 11, 2018: Materials
https://www.readbyqxmd.com/read/29748758/how-to-accurately-predict-solution-phase-gold-nanostar-stability
#7
Wenjing Xi, Hoa T Phan, Amanda J Haes
Unwanted nanoparticle aggregation and/or agglomeration may occur when anisotropic nanoparticles are dispersed in various solvents and matrices. While extended Derjaguin-Landau-Verwey-Overbeek (DLVO) theory has been successfully applied to predict nanoparticle stability in solution, this model fails to accurately predict the physical stability of anisotropic nanostructures; thus limiting its applicability in practice. Herein, DLVO theory was used to accurately predict gold nanostar stability in solution by investigating how the choice of the nanostar dimension considered in calculations influences the calculated attractive and repulsive interactions between nanostructures...
May 11, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29748684/recent-advances-in-merging-photonic-crystals-and-plasmonics-for-bioanalytical-applications
#8
Bing Liu, Hosein Monshat, Zhongze Gu, Meng Lu, Xiangwei Zhao
Photonic crystals (PhCs) and plasmonic nanostructures offer the unprecedented capability to control the interaction of light and biomolecules at the nanoscale. Based on PhC and plasmonic phenomena, a variety of analytical techniques have been demonstrated and successfully implemented in many fields, such as biological sciences, clinical diagnosis, drug discovery, and environmental monitoring. During the past decades, PhC and plasmonic technologies have progressed in parallel with their pros and cons. The merging of photonic crystals with plasmonics will significantly improve biosensor performances and enlarge the linear detection range of analytical targets...
May 11, 2018: Analyst
https://www.readbyqxmd.com/read/29747155/manual-punch-versus-automated-flow-through-sample-desorption-for-dried-blood-spot-lc-ms-ms-analysis-of-voriconazole
#9
Lisa C Martial, Erik van den Hombergh, Cornelis Tump, Otto Halmingh, David M Burger, Erik M van Maarseveen, Roger J Brüggemann, Rob E Aarnoutse
Dried blood spot (DBS) sampling is a patient-friendly alternative for plasma sampling for the purpose of therapeutic drug monitoring (TDM). To speed up the analysis time, an automated flow-through desorption method of DBS samples may be beneficial. This article describes the cross-validation of a manual punch DBS method with an automated desorption (DBS autosampler, DBSA) method for the DBS analysis of the antifungal drug voriconazole, followed by cross-validation of both DBS methods with a plasma-based method, and an assessment of agreement between DBS/DBSA and regular plasma concentration measurements (gold standard) in samples from patients on voriconazole treatment...
April 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29746726/formulation-and-in-vitro-in-vivo-correlation-between-two-candesartan-cilexetil-tablets
#10
Abdel Naser Zaid, Asma Radwan, Nidal Jaradat, Ayman Mousa, Nadia Ghazal, Rana Bustami
In this study, the in vitro and in vivo interchangeability between generic candesartan 16 mg and the branded formulation was assessed. The in vitro release of these products was conducted in 3 pH media (1.2, 5.0, and 6.8), and similarity factors (f2 ) were calculated. This bioequivalence study was a randomized, 2-period crossover study that included 42 healthy adult male subjects under fasting conditions with a 9-day washout. The pharmacokinetic (PK) parameters AUC0-last , AUC0-∞ , and Cmax , tmax , and the elimination half-life time were assessed based on the plasma concentrations of candesartan, using a newly developed and validated liquid chromatography-tandem mass spectrometry bioanalytical method with acceptable degrees of linearity, sensitivity, precision, and accuracy...
May 10, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29746395/a-liquid-chromatography-mass-spectrometry-assay-for-determination-of-perampanel-and-concomitant-antiepileptic-drugs-in-the-plasma-of-patients-with-epilepsy-compared-with-a-fluorescent-hplc-assay
#11
Ugo de Grazia, Annachiara D'Urso, Federica Ranzato, Valentina De Riva, Giorgia Contarato, Giuseppe Billo, Francesco Perini, Elisabetta Galloni
BACKGROUND: Perampanel is a novel non-competitive selective antagonist at the postsynaptic ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) glutamate receptor, approved as an adjunctive agent for the treatment of partial-onset seizure with or without secondary generalization and for primary generalized tonic-clonic seizure in patients with epilepsy who are at least 12 years of age. Limited information is available about the clinical utility of therapeutic drug monitoring of perampanel and therapeutic ranges are so far not established...
May 9, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29746100/combining-ion-mobility-and-cryogenic-spectroscopy-for-structural-and-analytical-studies-of-biomolecular-ions
#12
Michael Z Kamrath, Thomas R Rizzo
Ion mobility spectrometry (IMS) has become a valuable tool in biophysical and bioanalytical chemistry because of its ability to separate and characterize the structure of gas-phase biomolecular ions on the basis of their collisional cross section (CCS). Its importance has grown with the realization that in many cases, biomolecular ions retain important structural characteristics when produced in the gas phase by electrospray ionization (ESI). While a CCS can help distinguish between structures of radically different types, one cannot expect a single number to differentiate similar conformations of a complex molecule...
May 10, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29739124/verification-of-bioanalytical-method-for-quantification-of-exogenous-insulin-insulin-aspart-by-the-analyser-advia-centaur%C3%A2-xp
#13
Rossen Mihailov, Dilyana Stoeva, Blagovesta Pencheva, Eugeni Pentchev
BACKGROUND: In a number of cases the monitoring of patients with type I diabetes mellitus requires measurement of the exogenous insulin levels. For the purpose of a clinical investigation of the efficacy of a medical device for application of exogenous insulin aspart, a verification of the method for measurement of this synthetic analogue of the hormone was needed. The information in the available medical literature for the measurement of the different exogenous insulin analogs is insufficient...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738000/silver-nanowires-as-infrared-active-materials-for-surface-enhanced-raman-scattering
#14
Maurizio Becucci, Monica Bracciali, Giacomo Ghini, Cristiana Lofrumento, Giangaetano Pietraperzia, Marilena Ricci, Lorenzo Tognaccini, Silvana Trigari, Cristina Gellini, Alessandro Feis
Surface-enhanced Raman scattering (SERS) is increasing in significance as a bioanalytical tool. Novel nanostructured metal substrates are required to improve performances and versatility of SERS spectroscopy. In particular, as biological tissues are relatively transparent in the infrared wavelength range, SERS-active materials suitable for infrared laser excitation are needed. Nanowires appear interesting in this respect as they show a very broad localized surface plasmon resonance band, ranging from near UV to near infrared wavelengths...
May 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29733891/-connecting-worlds-a-view-on-microfluidics-for-a-wider-application
#15
REVIEW
Ana C Fernandes, Krist V Gernaey, Ulrich Krühne
From its birth, microfluidics has been referenced as a revolutionary technology and the solution to long standing technological and sociological issues, such as detection of dilute compounds and personalized healthcare. Microfluidics has for example been envisioned as: (1) being capable of miniaturizing industrial production plants, thereby increasing their automation and operational safety at low cost; (2) being able to identify rare diseases by running bioanalytics directly on the patient's skin; (3) allowing health diagnostics in point-of-care sites through cheap lab-on-a-chip devices...
May 4, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29733349/lc-ms-ms-determination-of-oxcarbazepine-and-an-active-metabolite-in-human-plasma-for-clinical-application
#16
Yuji Mano
A bioanalytical method for the simultaneous determination of oxcarbazepine (OXC) and its pharmacologically active metabolite, 10, 11-dihydro-10-hydroxycarbamazepine (HOXC), in human plasma was developed using a high-performance liquid chromatography with tandem mass spectrometry. After protein precipitation by acetonitrile, the analytes (OXC and HOXC) and a stable-labeled isotope of OXC as an internal standard (IS) were chromatographed on a Synergi Hydro-RP column (2.0 mm × 50 mm, 4 μm) with a gradient elution at a flow rate 0...
May 4, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29727780/an-lc-ms-ms-method-for-simultaneous-determination-of-curcumin-curcumin-glucuronide-and-curcumin-sulfate-in-a-phase-ii-clinical-trial
#17
Sandeep R Kunati, Shuming Yang, Basem M William, Yan Xu
Curcumin, a principal curcuminoid of turmeric, gained a lot of attention recently due to its wide spectrum of pharmacological activities in prevention and treatment of various human conditions. The current clinical study is focused on the determination of efficacy and tolerability of curcumin and vitamin D3 combination in patients with early-stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). To support this work, an LC-MS/MS method has been developed for simultaneous determination of curcumin and its metabolites, curcumin glucuronide (COG) and curcumin sulfate (COS), in human plasma using curcumin-d6 as an internal standard for curcumin and BPAG-d6 as an internal standard for COG and COS...
April 23, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29726619/development-and-validation-of-a-uplc-ms-method-for-the-determination-of-galantamine-in-guinea-pig-plasma-and-its-application-to-a-pre-clinical-bioavailability-study-of-novel-galantamine-formulations
#18
Jiang Wang, Naresh Pavurala, Xiaoming Xu, Yellela S R Krishnaiah, Patrick J Faustino
To evaluate the bioavailability and pharmacokinetic profiles of two novel galantamine formulations as medical countermeasure products, an ultra-performance liquid chromatography-single quadrupole mass spectrometry (UPLC-MS) method was developed and validated for quantifying galantamine in guinea pig plasma using solid phase extraction with a mixed mode strong cation exchange reversed phase cartridge. Chromatographic separation was achieved on a Waters Acquity UPLC BEH C18 column maintained at 40 °C. The mobile phases were solution-A acetonitrile-water (5:95, v/v) and solution-B acetonitrile-water (90:10, v/v), which both contain 2 mM ammonium formate and 0...
May 4, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29726023/the-determination-of-capreomycin-in-human-plasma-by-lc-ms-ms-using-ion-pairing-chromatography-and-solid-phase-extraction
#19
Blessings Thuboy, Tracy Kellermann, Sandra Castel, Jennifer Norman, Anton Joubert, Anthony J Garcia-Prats, Anneke C Hesseling, Lubbe Wiesner
A bioanalytical method was developed and validated for the quantification of Capreomycin (Cm) analogues, Cm IA and Cm IB, in human plasma. This implemented ion-pairing solid phase extraction (IP-SPE), followed by ion-pairing high performance liquid chromatography (IP-HPLC), with tandem mass spectrometry detection. Chromatographic separation was achieved using a Discovery C18, 5μm, 4.6 mm x 50 mm analytical column. An isocratic mobile phase consisting of water and acetonitrile with 0.1% formic acid and 4 mM Heptafluorobutyric acid (80,20; v/v), was used at a flow-rate of 500 μl per minute...
May 3, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29722051/liquid-chromatographic-tandem-mass-spectrometry-assay-for-the-quantification-of-mdt-637-in-human-nasal-wash
#20
Shane C Karnik, Robert Cook, Steve H Gorman, Ray Bakhtiar
MDT-637 is a new chemical entity (NCE) that shows potent and selective antiviral activity against Respiratory Syncytial Virus (RSV). As part of the new drug development program, a method for quantitating MDT-637 in nasal wash collected from human subjects was required. This article describes the method development, validation and application of a bioanalytical assay for MDT-637 in human nasal wash using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sample pretreatment utilized supported liquid extraction and final extracts were injected onto an Agilent Poroshell 120 EC-C18 column and eluted under isocratic conditions of 65/35 (v/v) 10 mM ammonium formate in water and acetonitrile Detection was performed on an API 5000 tandem mass spectrometer operating in negative electrospray ionization mode applying multiple reaction monitoring (MRM)...
May 2, 2018: Biomedical Chromatography: BMC
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