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Diabetes Type 3

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https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#1
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and favourably influence lipoprotein metabolism. The impact of BPD-DS surgery on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS surgery on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS surgery-associated caloric restriction (CR)...
August 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938465/serum-insulin-bioassay-reflects-insulin-sensitivity-and-requirements-in-type-1-diabetes
#2
Joseph A M J L Janssen, Gemma Llauradó, Aimee J Varewijck, Per-Henrik Groop, Carol Forsblom, Sonia Fernández-Veledo, Elisabeth S R van den Dungen, Joan Vendrell, Leo J Hofland, Hannele Yki-Järvinen
Background: Insulin resistance could increase insulin requirements in type 1 diabetes (TD1). Current insulin immunoassays do not detect insulin analogues. Kinase Insulin Receptor Activation (KIRA) bioassays specific for human insulin receptor isoforms A and B (IR-A and IR-B) permit assessment of all circulating insulin bioactivity. We studied whether IR-A and IR-B KIRA assays are related to direct measures of insulin sensitivity or insulin doses in TD1. Methods: We evaluated 31 adult patients with TD1 (age 45...
August 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938447/development-and-risk-factors-of-type-2-diabetes-in-a-nationwide-population-of-women-with-polycystic-ovary-syndrome
#3
Katrine Hass Rubin, Dorte Glintborg, Mads Nybo, Bo Abrahamsen, Marianne Andersen
Objective: Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Prospective population-based data regarding development and possible predictors of type 2 diabetes (T2D) in PCOS are limited. Design: National Register-based study. Methods: Patients with PCOS (PCOS Denmark and embedded cohort; PCOS OUH) and a control population with no previous diagnosis of T2D. PCOS OUH (N=1,162) included premenopausal women with PCOS and standardized clinical and biochemical examination...
August 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938142/insulin-regimens-and-glycemic-control-in-different-parts-of-europe-over-4years-after-starting-insulin-in-people-with-type-2-diabetes-data-from-the-credit-non-interventional-study
#4
Lawrence Blonde, Michel Marre, Maya Vincent, Sandrine Brette, Valerie Pilorget, Nicholas Danchin, Giacomo Vespasiani, Philip Home
AIMS: A number of insulin regimens are used in type 2 diabetes. This analysis aims to better understand the evolution of insulin therapy in different regions of Europe. METHODS: Data from people starting any insulin were collected in eastern Europe (EEur: Croatia, Russia, Ukraine), northern Europe (NEur: Finland, Germany, UK) and southern Europe (SEur: France, Italy, Portugal, Spain). Retrospective data on starting insulin and prospective follow-up data were extracted from clinical records...
August 31, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28937039/safety-and-necessity-of-antiplatelet-therapy-on-patients-underwent-endovascular-aortic-repair-with-both-stanford-type-b-aortic-dissection-and-coronary-heart-disease
#5
Rui-Xia He, Lei Zhang, Tie-Nan Zhou, Wen-Jie Yuan, Yan-Jie Liu, Wen-Xia Fu, Quan-Min Jing, Hai-Wei Liu, Xiao-Zeng Wang
BACKGROUND: Acute aortic dissection is known as the most dangerous aortic disease, with management and prognosis determined as the disruption of the medial layer provoked by intramural bleeding. The objective of this study was to evaluate the safety and necessity of antiplatelet therapy on patients with Stanford Type B aortic dissection (TBAD) who underwent endovascular aortic repair (EVAR). METHODS: The present study retrospectively analyzed 388 patients with TBAD who underwent EVAR and coronary angiography...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936841/-determination-of-six-alkaloids-in-six-types-of-coptidis-rhizoma-pieces-by-rp-hplc-and-spectrum-effect-relationships-with-anti-diabetes-pharmacodynamics-data
#6
Xian-Rong Lai, Bang-Hua Zhou, Ming-Sheng Du, Hai-Jie Zheng, Zhi-Peng Geng, Jia-Chuan Li, Xian-Li Meng, Yi Zhang, Jing Zhang
To establish a method for determining the contents of six alkaloids (jatrorrhizine hydrochloride, columbamine hydrochloride, epiberberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride, berberine hydrochloride) in six types of Coptidis Rhizoma pieces (crude pieces, ginger juice stir-fried pieces, vinegar stir-fried pieces, wine steamed pieces, wine stir-fried pieces, evodiae juice stir-fried pieces) by RP-HPLC, and explore the relationship with the curative effect of traditional Chinese medicine (TCM) and pharmacodynamics results...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936587/metabolite-ratios-as-potential-biomarkers-for-type-2-diabetes-a-direct-study
#7
Sophie Molnos, Simone Wahl, Mark Haid, E Marelise W Eekhoff, René Pool, Anna Floegel, Joris Deelen, Daniela Much, Cornelia Prehn, Michaela Breier, Harmen H Draisma, Nienke van Leeuwen, Annemarie M C Simonis-Bik, Anna Jonsson, Gonneke Willemsen, Wolfgang Bernigau, Rui Wang-Sattler, Karsten Suhre, Annette Peters, Barbara Thorand, Christian Herder, Wolfgang Rathmann, Michael Roden, Christian Gieger, Mark H H Kramer, Diana van Heemst, Helle K Pedersen, Valborg Gudmundsdottir, Matthias B Schulze, Tobias Pischon, Eco J C de Geus, Heiner Boeing, Dorret I Boomsma, Anette G Ziegler, P Eline Slagboom, Sandra Hummel, Marian Beekman, Harald Grallert, Søren Brunak, Mark I McCarthy, Ramneek Gupta, Ewan R Pearson, Jerzy Adamski, Leen M 't Hart
AIMS/HYPOTHESIS: Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabetes...
September 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/28936576/improvement-of-continuous-subcutaneous-insulin-infusion-on-patients-with-type-2-diabetes-mellitus-by-3-dimensional-speckle-tracking-echocardiography
#8
Hong-Xia Luo, Xiao-Ling Zhou, Hong-Ju Kou, Xian-Wei Ni, Qing Wu, Chun-Peng Zou, Dao-Zhu Wu, Yong-Fang Liu
Three-dimensional speckle tracking echocardiography (3D-STE) was used to evaluate the improvement of continuous subcutaneous insulin infusion on the left ventricular (LV) systolic function of patients with type 2 diabetes mellitu (T2DM). We recruited T2DM patients (38 cases, diabetic group) and healthy volunteers (35 cases, control group) to collect LV full volume imaging. TomTec software was used for calculating LV global longitudinal strain (LVGLS), global circumferential strain (LVGCS), peak twist (LVTW), peak apical rotation (LVPAR), ejection fraction (LVEF), and torsion (LVT)...
September 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28936434/prevalence-of-diabetic-foot-ulceration-and-associated-risk-factors-an-old-and-still-major-public-health-problem-in-khartoum-sudan
#9
Ahmed O Almobarak, Heitham Awadalla, Mugtaba Osman, Mohamed H Ahmed
BACKGROUND: Diabetic foot ulceration (DFU) is a major health problem across the globe. The objective of this study is to determine the prevalence of DFU and its associated risk factors in Sudanese individuals with diabetes. METHODS: Three hundred and ten individuals with type 2 diabetes, who have been on treatment for DM for at least 1 year and volunteered to participate, were enrolled in this study. Participants were interviewed using standardized pretested questionnaire to record medical history, socio-demographic, life style characteristics and presence of DFU...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28936426/comparison-of-diabetic-and-non-diabetic-human-leukocytic-responses-to-different-capsule-types-of-klebsiella-pneumoniae-responsible-for-causing-pyogenic-liver-abscess
#10
I Russel Lee, Ethel Sng, Kok-Onn Lee, James S Molton, Monica Chan, Shirin Kalimuddin, Ezlyn Izharuddin, David C Lye, Sophia Archuleta, Yunn-Hwen Gan
The major risk factor for Klebsiella liver abscess (KLA) is type 2 diabetes mellitus (DM), but the immunological mechanisms involved in the increased susceptibility are poorly defined. We investigated the responses of neutrophils and peripheral blood mononuclear cells (PBMCs) to hypervirulent Klebsiella pneumoniae (hvKP), the causative agent of KLA. DNA and myeloperoxidase levels were elevated in the plasma of KLA patients compared to uninfected individuals indicating neutrophil activation, but diabetic status had no effect on these neutrophil extracellular trap (NET) biomarkers in both subject groups...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28936050/comparative-evaluation-of-corneal-endothelium-in-patients-with-diabetes-undergoing-phacoemulsification
#11
Pramod K Sahu, Gopal K Das, Sumeet Agrawal, Sabitabh Kumar
PURPOSE: The purpose of this study is to determine if phacoemulsification with posterior chamber foldable intraocular lens implantation has a greater impact on the corneal endothelium of type 2 diabetic patients as compared to nondiabetic controls. MATERIALS AND METHODS: This study compared the corneal endothelial status in sixty patients with diabetes with good glycemic control and sixty nondiabetic controls before and after (1 week, 1 month, 2 month, and 3 month) uneventful phacoemulsification...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28935934/serum-uric-acid-to-creatinine-ratio-and-risk-of-metabolic-syndrome-in-saudi-type-2-diabetic-patients
#12
Nasser M Al-Daghri, Omar S Al-Attas, Kaiser Wani, Shaun Sabico, Majed S Alokail
This study aimed to investigate whether uric acid to creatinine (UA/Cr) ratio is associated with higher risk of metabolic syndrome (MetS) and its components. 332 adult Saudi type 2 diabetes mellitus (T2DM) patients were divided into UA/Cr tertiles. Risk for full MetS was significantly highest in individuals that constitutes the uppermost serum UA/Cr tertile [Odds ratio (OR): 1.80, 95% confidence interval (CI): 1.0-3.3; p < 0.001) after adjustment for age, gender and BMI. Similarly, risk for individual components of MetS like central obesity, hypertriglyceridemia, low HDL-cholesterol and hypertension was significantly highest in this tertile with OR's of 2...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935628/effect-of-exercise-induced-lactate-elevation-on-brain-lactate-levels-during-hypoglycemia-in-patients-with-type-1-diabetes-and-impaired-awareness-of-hypoglycemia
#13
Evita C Wiegers, Hanne M Rooijackers, Cees J Tack, Hans J M M Groenewoud, Arend Heerschap, Bastiaan E de Galan, Marinette van der Graaf
Since altered brain lactate handling has been implicated in the development of impaired awareness of hypoglycemia (IAH) in type 1 diabetes, the capacity to transport lactate into the brain during hypoglycemia may be relevant in its pathogenesis. High-intensity interval training (HIIT) increases plasma lactate levels. We compared the effect of HIIT-induced hyperlacticacidemia on brain lactate during hypoglycemia between 1) patients with type 1 diabetes and IAH, 2) patients with type 1 diabetes and normal awareness of hypoglycemia (NAH), and 3) healthy non-diabetic participants (n=6 per group)...
September 21, 2017: Diabetes
https://www.readbyqxmd.com/read/28935081/efficacy-and-safety-of-the-absorb-bioresorbable-vascular-scaffold-in-females-and-males-results-of-an-individual-patient-level-pooled-meta-analysis-of-randomized-controlled-trials
#14
Satya Shreenivas, Dean J Kereiakes, Stephen G Ellis, Runlin Gao, Takeshi Kimura, Yoshinobu Onuma, Karine Piard-Ruster, Yunlong Zhang, Kai Koo, Minh-Thien Vu, Patrick W Serruys, Gregg W Stone
OBJECTIVES: Because females are under-represented in coronary trials, this study sought to assess the relative safety and efficacy of Absorb bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) and the Xience everolimus-eluting stent in females compared with males. BACKGROUND: The Absorb everolimus-eluting BVS provides drug delivery and mechanical support similar to a metallic drug-eluting stent, followed by resorption and restoration of more normal vascular structure with the potential to improve late clinical outcomes...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28935073/incidence-clinical-presentation-and-predictors-of-clinical-restenosis-in-coronary-bioresorbable-scaffolds
#15
Alberto Polimeni, Melissa Weissner, Katharina Schochlow, Helen Ullrich, Ciro Indolfi, Jouke Dijkstra, Remzi Anadol, Thomas Münzel, Tommaso Gori
OBJECTIVES: The aim of this study was to describe the incidence and clinical characteristics, including intracoronary imaging features, of clinical restenosis in bioresorbable coronary scaffolds (BRS). Further, the authors searched for clinical and procedural predictors of scaffold restenosis (ScR) and report on the clinical outcomes after treatment of ScR in a cohort of consecutive all-comer patients. BACKGROUND: Data from randomized controlled trials demonstrate a higher rate of target lesion failure in patients treated with BRS as compared with those treated with metal drug-eluting stents...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28934940/human-development-index-hdi-of-the-maternal-country-of-origin-as-a-predictor-of-perinatal-outcomes-a-longitudinal-study-conducted-in-spain
#16
S Garcia-Tizon Larroca, J Arevalo-Serrano, A Duran Vila, M P Pintado Recarte, I Cueto Hernandez, A Solis Pierna, S Lizarraga Bonelli, J De Leon-Luis
BACKGROUND: In an era of worldwide population displacement, recent studies have identified strong associations between social situations and perinatal outcomes among immigrants. Little is known about the effect of maternal social background on pregnancy outcomes. The Human Development Index (HDI) assesses the following dimensions of human development: life expectancy, education level and income. The objective of our study was to determine if maternal HDI may be used to identify women at increased odds of poor pregnancy outcomes...
September 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28934671/the-hnf1a-mutant-ala180val-clinical-challenges-in-determining-causality-of-a-rare-hnf1a-variant-in-familial-diabetes
#17
J V Sagen, L Bjørkhaug, B I Haukanes, L Grevle, J Molnes, B G Nedrebø, O Søvik, P R Njølstad, S Johansson, A Molven
AIMS: Heterozygous mutations in hepatocyte nuclear factor-1A (HNF1A) cause maturity-onset diabetes of the young type 3 (MODY3). Our aim was to compare two families with suspected dominantly inherited diabetes and a new HNF1A variant of unknown clinical significance. METHODS: The HNF1A gene was sequenced in two independently recruited families from the Norwegian MODY Registry. Both familes were phenotyped clinically and biochemically. Microsatellite markers around and within the HNF1A locus were used for haplotyping...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934670/conflicting-interactions-of-apolipoprotein-a-and-high-density-lipoprotein-cholesterol-with-microvascular-complications-of-type-2-diabetes
#18
Zahra Aryan, Mohsen Afarideh, Alireza Ghajar, Sadaf Esteghamati, Alireza Esteghamati, Manouchehr Nakhjavani
AIMS: This study is amid at investigating the associations, and interactions of serum lipid biomarkers with microvascular complications of type 2 diabetes (T2D). METHODS: A nested case-control study was conducted within an ongoing prospective study on patients with T2D. Microvascular complications of T2D including diabetic neuropathy, diabetic retinopathy and diabetic nephropathy were investigated. A total of 444 cases with at least one of the microvascular complications of T2D and 439 age- and gender-matched controls free of any of the chronic microvascular complications of T2D were included...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934557/a-safety-evaluation-of-empagliflozin-plus-linagliptin-for-treating-type-2-diabetes
#19
Baptist Gallwitz
Dipeptidyl-peptidase-IV inhibitors (DPP-4i) and sodium-glucose-transporter-2 inhibitors (SGLT-2i) are oral antidiabetic drugs that improve glycemic parameters and possess a very low intrinsic hypoglycemia risk and favorable cardiovascular data. Areas covered: An overview on the clinical studies investigating the combination therapy with the DPP-4i linagliptin and the SGLT-2i empagliflozin is given. The clinical evidence for the efficacy and safety of free combinations as well as for their fixed dose combinations is presented...
September 21, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28933769/a-lanosteryl-triterpene-from-protorhus-longifolia-improves-glucose-tolerance-and-pancreatic-beta-cell-ultrastructure-in-type-2-diabetic-rats
#20
Sihle E Mabhida, Rebamang A Mosa, Dambudzo Penduka, Foluso O Osunsanmi, Phiwayinkosi V Dludla, Tryana G Djarova, Andy R Opoku
Type 2 diabetes remains one of the leading causes of death worldwide. Persistent hyperglycemia within a diabetic state is implicated in the generation of oxidative stress and aggravated inflammation that is responsible for accelerated modification of pancreatic beta cell structure. Here we investigated whether a lanosteryl triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA-3), isolated from Protorhus longifolia can improve glucose tolerance and pancreatic beta cell ultrastructure by reducing oxidative stress and inflammation in high fat diet and streptozotocin-induced type 2 diabetes in rats...
July 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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