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Microvascular disease

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https://www.readbyqxmd.com/read/28239641/macrovascular-and-microvascular-cerebral-blood-flow-in-adults-at-risk-for-alzheimer-s-disease
#1
Lindsay R Clark, Sara E Berman, Leonardo A Rivera-Rivera, Siobhan M Hoscheidt, Burcu F Darst, Corinne D Engelman, Howard A Rowley, Cynthia M Carlsson, Sanjay Asthana, Patrick Turski, Oliver Wieben, Sterling C Johnson
INTRODUCTION: Capillary hypoperfusion is reported in asymptomatic adults at-risk for Alzheimer's disease (AD), but the extent that can be explained by reduced flow in intracranial arteries is unknown. METHODS: One hundred fifty-five asymptomatic adults enriched for AD risk (mean age 61 years) completed arterial spin labeling (pcASL) and 4D-flow MRI sequences. Voxel-wise regression models investigated the relationship between mean flow in bilateral cerebral arteries and capillary perfusion, and tested potential moderators of this relationship...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28238066/crocin-inhibits-oxidative-stress-and-pro-inflammatory-response-of-microglial-cells-associated-with-diabetic-retinopathy-through-the-activation-of-pi3k-akt-signaling-pathway
#2
Xinguang Yang, Fuquan Huo, Bei Liu, Jing Liu, Tao Chen, Junping Li, Zhongqiao Zhu, Bochang Lv
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus that is closely associated with the degeneration and loss of retinal ganglion cells (RGCs) caused by diabetic microangiopathy and subsequent oxidative stress and an inflammatory response. Microglial cells are classed as neurogliocytes and play a significant role in neurodegenerative diseases. Over-activated microglial cells may cause neurotoxicity and induce the death and apoptosis of RGCs. Crocin is one of the two most pharmacologically bioactive constituents in saffron...
February 25, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28237964/vulnerability-to-oxygen-glucose-deprivation-of-primary-neurons-derived-from-tg2576-alzheimer-mice-role-of-intraneuronal-abeta-accumulation-and-astrocytes
#3
Vito Antonio Baldassarro, Alessandra Marchesini, Luciana Giardino, Laura Calzà
Microvascular dysfunction is considered an integral part of Alzheimer disease (AD) pathogenesis, but the possible relationship between amyloid pathology, microvascular dysfunction and cell death is still unclear. In order to investigate the influence of intraneuronal Abeta (Aβ) accumulation on vulnerability to hypoxia, we isolated primary cortical neurons from Tg2576 (carrying the APPSwe mutation) and Wt fetal mice. We first demonstrated that neurons isolated from Tg2576 new-born mice show an increase in VEGFa mRNA expression and a decrease in the expression of the two VEGF receptors, i...
February 24, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28237791/long-term-incidence-of-microvascular-disease-after-bariatric-surgery-or-usual-care-in-patients-with-obesity-stratified-by-baseline-glycaemic-status-a-post-hoc-analysis-of-participants-from-the-swedish-obese-subjects-study
#4
Lena M S Carlsson, Kajsa Sjöholm, Cecilia Karlsson, Peter Jacobson, Johanna C Andersson-Assarsson, Per-Arne Svensson, Ingrid Larsson, Stephan Hjorth, Martin Neovius, Magdalena Taube, Björn Carlsson, Markku Peltonen
BACKGROUND: Bariatric surgery is associated with remission of diabetes and prevention of diabetic complications in patients with obesity and type 2 diabetes. Long-term effects of bariatric surgery on microvascular complications in patients with prediabetes are unknown. The aim of this study was to examine the effects of bariatric surgery on incidence of microvascular complications in patients with obesity stratified by baseline glycaemic status. METHODS: Patients were recruited to the Swedish Obese Subjects (SOS) study between Sept 1, 1987, and Jan 31, 2001...
February 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28237138/optical-coherence-tomography-angiography-in-chorioretinal-disorders
#5
REVIEW
Paulo Ricardo Chaves De Oliveira, Alan Richard Berger, David Robert Chow
Optical coherence tomography angiography (OCTA) is a novel imaging modality that incorporates blood motion contrast to create angiograms of the retinal vasculature in a noninvasive manner, without the use of dye. It is a safe procedure and can be repeated as frequently as desired. The use of OCTA for delineation of choroidal neovascular membranes, for the study of microvascular abnormalities in diabetic patients, to assess nonperfused areas in retinal occlusions and vascular changes in macular telangiectasia are some of the potential OCTA applications...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28236373/insidious-incrementalism-the-silent-failure-of-the-microcirculation-with-increasing-peripheral-vascular-disease-risk
#6
REVIEW
Kent Lemaster, Dwayne Jackson, Daniel Goldman, Jefferson C Frisbee
This review summarizes material presented in "Adaptive Outcomes of Microvascular Networks to Obesity and Type II Diabetes/Insulin Resistance" on July 30, 2016, at the Joint Meeting of the American Physiological Society and the Physiological Society, in Dublin, Ireland. We discuss the poor predictive power of traditional markers of vascular dysfunction for functional outcomes of muscle fatigue-resistance and active hyperemia within the setting of elevated peripheral vascular disease risk. Using the obese Zucker rat model of the metabolic syndrome, we describe how blood flow distribution at arteriolar bifurcations (γ) is altered with PVD risk reflecting increased spatial heterogeneity of distribution within networks...
February 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28236166/alteration-of-regional-homogeneity-and-white-matter-hyperintensities-in-amnestic-mild-cognitive-impairment-subtypes-are-related-to-cognition-and-csf-biomarkers
#7
Xiao Luo, Yerfan Jiaerken, Peiyu Huang, Xiao Jun Xu, Tiantian Qiu, Yunlu Jia, Zhujing Shen, Xiaojun Guan, Jiong Zhou, Minming Zhang
Amnestic mild cognitive impairment can be further classified as single-domain aMCI (SD-aMCI) with isolated memory deficit, or multi-domain aMCI (MD-aMCI) if memory deficit is combined with impairment in other cognitive domains. Prior studies reported these clinical subtypes presumably differ in etiology. Thus, we aimed to explore the possible mechanisms between different aMCI subtypes by assessing alteration in brain activity and brain vasculature, and their relations with CSF AD biomarkers. 49 healthy controls, 32 SD-aMCI, and 32 MD-aMCI, who had undergone structural scans, resting-state functional MRI (rsfMRI) scans and neuropsychological evaluations, were identified...
February 24, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28230445/benchmarking-insulin-treatment-persistence-among-patients-with-type-2-diabetes-across-different-u-s-payer-segments
#8
Wenhui Wei, Jenny Jiang, Youbei Lou, Sohini Ganguli, Mark S Matusik
BACKGROUND: Treatment persistence with basal insulins is crucial to achieving sustained glycemic control, which is associated with a reduced risk of microvascular disease and other complications of type 2 diabetes (T2D). However, studies suggest that persistence with basal insulin treatment is often poor. OBJECTIVE: To measure and benchmark real-world basal insulin treatment persistence among patients with T2D across different payer segments in the United States...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28229127/the-application-of-retinal-fundus-camera-imaging-in-dementia-a-systematic-review
#9
REVIEW
Sarah McGrory, James R Cameron, Enrico Pellegrini, Claire Warren, Fergus N Doubal, Ian J Deary, Baljean Dhillon, Joanna M Wardlaw, Emanuele Trucco, Thomas J MacGillivray
INTRODUCTION: The ease of imaging the retinal vasculature, and the evolving evidence suggesting this microvascular bed might reflect the cerebral microvasculature, presents an opportunity to investigate cerebrovascular disease and the contribution of microvascular disease to dementia with fundus camera imaging. METHODS: A systematic review and meta-analysis was carried out to assess the measurement of retinal properties in dementia using fundus imaging. RESULTS: Ten studies assessing retinal properties in dementia were included...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28228905/calciphylaxis-on-bone-scan-correlation-between-molecular-and-cross-sectional-findings
#10
Malak Itani, Manuela Matesan, Sanaz Behnia, Saeed Elojeimy
Calciphylaxis is a rare devastating medical condition commonly associated with end-stage renal disease and characterized by extensive microvascular calcifications. We describe a case of calciphylaxis presenting on Tc-99m MDP bone scan imaging with asymmetric radiotracer uptake within the lower extremities corresponding to extensive soft tissue calcifications on Computed tomography. Familiarity with the classic clinical presentation and imaging features of this rare entity may help its early identification and treatment...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228373/statins-and-fibrates-for-diabetic-retinopathy-protocol-for-a-systematic-review
#11
Vania Mozetic, Carolina Gomes Freitas, Rachel Riera
BACKGROUND: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus, and more than 75% of patients who have had diabetes for more than 20 years will have some degree of DR. This disease is highly destructive to self-esteem and puts a high burden on public health and pension systems due to the effects that it has on people of working age. The current mainstay of treatment is laser photocoagulation, which causes impairment of vision and discomfort to patients...
February 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28226574/a-temperature-controlled-glove-with-non-invasive-arterial-pulse-sensing-for-active-neuro-vascular-assessment
#12
Andrew M Carek, Omer T Inan, Andrew M Carek, Omer T Inan, Andrew M Carek, Omer T Inan
A non-invasive, active neuro-vascular assessment system was developed using a modified temperature-controlled glove and feedback techniques. The glove incorporates local heating and cooling of the hand using multi-point skin temperature measurements as feedback, and thereby induces local and central mechanisms involved in thermoregulation. Electrocardiogram (ECG), photoplethysmogram (PPG) and non-invasive finger-cuff based blood pressure (BP) measurements were used to monitor electrophysiology and hemodynamic changes in response to temperature modulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225900/chronic-chagas-cardiomyopathy-a-review-of-the-main-pathogenic-mechanisms-and-the-efficacy-of-aetiological-treatment-following-the-benznidazole-evaluation-for-interrupting-trypanosomiasis-benefit-trial
#13
Anis Rassi, José Antonio Marin, Anis Rassi
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America. Although the pathogenesis of Chagas cardiomyopathy is incompletely understood, it may involve several mechanisms, including parasite-dependent myocardial damage, immune-mediated myocardial injury (induced by the parasite itself and by self-antigens), and microvascular and neurogenic disturbances. In the past three decades, a consensus has emerged that parasite persistence is crucial to the development and progression of Chagas cardiomyopathy...
March 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28225894/chronic-chagas-cardiomyopathy-a-review-of-the-main-pathogenic-mechanisms-and-the-efficacy-of-aetiological-treatment-following-the-benznidazole-evaluation-for-interrupting-trypanosomiasis-benefit-trial
#14
Anis Rassi, José Antonio Marin, Anis Rassi
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America. Although the pathogenesis of Chagas cardiomyopathy is incompletely understood, it may involve several mechanisms, including parasite-dependent myocardial damage, immune-mediated myocardial injury (induced by the parasite itself and by self-antigens), and microvascular and neurogenic disturbances. In the past three decades, a consensus has emerged that parasite persistence is crucial to the development and progression of Chagas cardiomyopathy...
February 16, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28221677/cardiovascular-disease-in-relation-to-placental-abruption-a%C3%A2-population-based-cohort-study-from-denmark
#15
Cande V Ananth, Anne Vinkel Hansen, Michelle A Williams, Anne-Marie Nybo Andersen
BACKGROUND: Cardiovascular (CVD) complications stemming from vascular dysfunction have been widely explored in the setting of preeclampsia. However, the impact of abruption, a strong indicator of microvascular disturbance, on the risk of CVD mortality and morbidity remains poorly characterised. METHODS: We designed a cohort analysis of 828 289 women who delivered singletons in Denmark between 1978 and 2010. We linked the National Patient Registry and the Registry of Causes of Death to the Danish Birth Registry to ascertain CVD events...
February 21, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28220848/elevated-expression-of-placental-growth-factor-is-associated-with-airway-wall-vascular-remodelling-and-thickening-in-smokers-with-asthma
#16
Dong Wu, Tianwen Lai, Yalian Yuan, Min Chen, Jun Xia, Wen Li, Guihai Pan, Binfan Yuan, Quanchao Lv, Yanyu Li, Dongmin Li, Bin Wu
The increased expression of placental growth factor (PlGF) in chronic obstructive pulmonary disease and allergy-related asthma suggests its role in the pathogenesis of these diseases. In asthmatic smokers, airway remodelling is accompanied by an accelerated decline in lung function. However, whether PlGF contributes to the persistent airflow obstruction and vascular remodelling typically seen in asthmatic smokers is unknown. In this study we measured lung function, airway-wall thickening, and PlGF levels in serum and induced sputum in 74 asthmatic and 42 healthy smokers and never-smokers...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219921/predictive-value-of-dobutamine-stress-perfusion-echocardiography-in-contemporary-end-stage-liver-disease
#17
Bipul Baibhav, Chetaj A Mahabir, Feng Xie, Valerie K Shostrom, Timothy M McCashland, Thomas R Porter
BACKGROUND: The assessment of cardiac risk in contemporary liver transplantation (LT) has required more sensitive testing for the detection of occult coronary artery disease as well as microvascular and functional cardiac abnormalities. Because dobutamine stress perfusion echocardiography provides an assessment of both regional systolic and diastolic function as well as microvascular perfusion (MVP), we sought to examine its incremental value in this setting. METHODS AND RESULTS: We evaluated the predictive value of dobutamine stress perfusion echocardiography in 296 adult patients with end-stage liver disease and preserved systolic function who underwent LT between 2008 and 2014...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28216818/limb-salvage-with-microvascular-free-fibula-following-primary-bone-sarcoma-resection
#18
Sahasrabudhe Parag, Panchwagh Yogesh, Jesal Rathod, Panse Nikhil, Jadhav Amit
BACKGROUND: Extremity sarcomas are challenging to manage. Total eradication of tumour has to be balanced with restoration of limb function to prevent mortality and morbidity. Disease-free survival with maximum limb function is the ultimate goal in these patients. MATERIALS AND METHODS: We present a series of ten cases of extremity malignancies, where limb salvage was attempted with microvascular free fibula for limb reconstruction from the period of 2008 to 2015...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28216508/-idiopathic-mesenteric-phlebosclerosis-one-case-report-and-literature-review
#19
Yonghong Jiang, Shan Huang, Kequan Chen, Xueqing Chen
Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease and it is easy to be misdiagnosed, which is characterized by intestinal obstruction symptoms, such as abdominal pain, bloating and vomiting. In this study, a case of IMP was observed and the literatures were reviewed. Computed tomography shows funicular high-density shadow and vascular calcification shadow along the vessels around the bowels. Narrow band imaging (M-NBI) endoscopy revealed the disappeared honeycomb capillary, the disordered microvascular structure and the increased density of blood vessels...
January 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28215575/fibronectin-connecting-segment-1-peptide-inhibits-pathogenic-leukocyte-trafficking-and-inflammatory-demyelination-in-experimental-models-of-chronic-inflammatory-demyelinating-polyradiculoneuropathy
#20
Chaoling Dong, Kelsey M Greathouse, Rebecca L Beacham, Steven P Palladino, E Scott Helton, Eroboghene E Ubogu
The molecular determinants of pathogenic leukocyte migration across the blood-nerve barrier (BNB) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are unknown. Specific disease modifying therapies for CIDP are also lacking. Fibronectin connecting segment-1 (FNCS1), an alternatively spliced fibronectin variant expressed by microvascular endothelial cells at sites of inflammation in vitro and in situ, is a counterligand for leukocyte α4 integrin (also known as CD49d) implicated in pathogenic leukocyte trafficking in multiple sclerosis and inflammatory bowel disease...
February 16, 2017: Experimental Neurology
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