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Macrovascular disease

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https://www.readbyqxmd.com/read/28921256/relation-between-different-measures-of-glycemic-exposure-and-microvascular-and-macrovascular-complications-in-patients-with-type-2-diabetes-mellitus-an-observational-cohort-study
#1
Rients P T van Wijngaarden, Jetty A Overbeek, Edith M Heintjes, Agata Schubert, Joris Diels, Huub Straatman, Ewout W Steyerberg, Ron M C Herings
INTRODUCTION: This retrospective cohort study investigated the relation between different measures of glycemic exposure and micro- and macrovascular complications among patients with type 2 diabetes. METHODS: The analysis included patients receiving oral antihyperglycemic agents between 1 January 2006 and 31 December 2014 from the General Practitioner Database from the PHARMO Database Network. All recorded HbA1c levels during follow-up were used to express glycemic exposure in four ways: index HbA1c, time-dependent HbA1c, exponential moving average (EMA) and glycemic burden...
September 18, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28915818/the-impact-of-cardiovascular-co-morbidities-and-duration-of-diabetes-on-the-association-between-microvascular-function-and-glycaemic-control
#2
F Casanova, D D Adingupu, F Adams, K M Gooding, H C Looker, K Aizawa, F Dove, S Elyas, J J F Belch, P E Gates, R C Littleford, M Gilchrist, H M Colhoun, A C Shore, F Khan, W D Strain
BACKGROUND: Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest glycaemic targets be relaxed in advanced diabetes. We explored whether disease duration or pre-existing macrovascular complications attenuated the association between hyperglycaemia and microvascular function. METHODS: 743 participants with T2DM (n = 222), cardiovascular disease (CVD = 183), both (n = 177) or neither (controls = 161) from two centres in the UK, underwent standard clinical measures and endothelial dependent (ACh) and independent (SNP) microvascular function assessment using laser Doppler imaging...
September 15, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28912211/body-mass-index-is-associated-with-microvascular-endothelial-dysfunction-in-patients-with-treated-metabolic-risk-factors-and-suspected-coronary-artery-disease
#3
Dirk J van der Heijden, Maarten A H van Leeuwen, Gladys N Janssens, Mattie J Lenzen, Peter M van de Ven, Etto C Eringa, Niels van Royen
BACKGROUND: Obesity is key feature of the metabolic syndrome and is associated with high cardiovascular morbidity and mortality. Obesity is associated with macrovascular endothelial dysfunction, a determinant of outcome in patients with coronary artery disease. Here, we compared the influence of obesity on microvascular endothelial function to that of established cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolemia, and smoking in patients with suspected coronary artery disease...
September 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28911684/a-randomized-double-blind-clinical-study-to-determine-the-effect-of-ankascin-568-plus-on-blood-glucose-regulation
#4
Yin-Ruei Wang, Sheng-Fu Liu, You-Cheng Shen, Chien-Li Chen, Chine-Ning Huang, Tzu-Ming Pan, Chin-Kun Wang
Diabetes is the fourth major cause of death in Taiwan. High blood glucose can lead to macrovascular diseases, small vessel diseases (retinopathy, kidney disease), and neuropathy. This study aimed to investigate whether Monascus-fermented products (ANKASCIN 568 plus) can regulate blood glucose and blood lipids. This study enrolled 39 patients with a fasting blood glucose level between 100 mg/dL and 180 mg/dL, and a glycated hemoglobin (HbA1c) level of <9%. All patients were randomly divided into placebo (n=20) and experimental (n=19) groups...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28906481/insights-into-the-diagnostic-potential-of-extracellular-vesicles-and-their-mirna-signature-from-liquid-biopsy-as-early-biomarkers-of-diabetic-micro-macrovascular-complications
#5
REVIEW
Valeria La Marca, Alessandra Fierabracci
Extracellular vesicles (EVs) represent a heterogeneous population of small vesicles, consisting of a phospholipidic bilayer surrounding a soluble interior cargo. Almost all cell types release EVs, thus they are naturally present in all body fluids. Among the several potential applications, EVs could be used as drug delivery vehicles in disease treatment, in immune therapy because of their immunomodulatory properties and in regenerative medicine. In addition to general markers, EVs are characterized by the presence of specific biomarkers (proteins and miRNAs) that allow the identification of their cell or tissue origin...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28904002/assessing-microvascular-function-in-humans-from-a-chronic-disease-perspective
#6
Alfons J H M Houben, Remy J H Martens, Coen D A Stehouwer
Microvascular dysfunction (MVD) is considered a crucial pathway in the development and progression of cardiometabolic and renal disease and is associated with increased cardiovascular mortality. MVD often coexists with or even precedes macrovascular disease, possibly due to shared mechanisms of vascular damage, such as inflammatory processes and oxidative stress. One of the first events in MVD is endothelial dysfunction. With the use of different physiologic or pharmacologic stimuli, endothelium-dependent (micro)vascular reactivity can be studied...
September 13, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28898609/-diabetes-screening-in-patients-with-macrovascular-coronary-disease-are-the-new-european-guidelines-a-step-backwards
#7
Andreia Ribeiro, Sérgio Bravo Baptista, Mariana Faustino, Paulo Alves, Pedro Farto Abreu, Victor Machado Gil, Carlos Morais
BACKGROUND: The new European guidelines on diabetes mellitus and cardiovascular diseases propose that the FINnish Diabetes RIsk SCore should be used to evaluate the risk of diabetes mellitus and that diabetes mellitus screening in coronary artery disease patients should be based on fasting glucose and HbA1c. The 2 hour oral glucose tolerance test, recommended for all pts in the previous guidelines, is now only recommended for 'inconclusive' cases. We aimed to evaluate this new strategy...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28898558/combination-of-capillaroscopic-and-ultrasonographic-evaluations-in-systemic-sclerosis-results-of-a-cross-sectional-study
#8
Alain Lescoat, Guillaume Coiffier, Marine de Carlan, Catherine Droitcourt, Alice Ballerie, Cazalets Claire, Aleth Perdriger, Jégo Patrick
OBJECTIVES: To compare microvascular damages on nailfold capillaroscopy (NC) with macrovascular manifestations evaluated by hand power doppler ultrasonography (PDUS) in Systemic Sclerosis (SSc) patients, and to assess the associations of these damages with the main digital manifestations of the disease: digital ulcers (DU), acro-osteolysis and Calcinosis. METHODS: NC, hand X-Rays and PDUS were systematically performed in 64 unselected SSc patients. PDUS evaluation with assessment of ulnar artery occlusion (UAO) and finger pulp blood flow (FPBF) was performed blinded for the results of X-Rays and NC...
September 12, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28895276/osteoporotic-fractures-may-impair-life-as-much-as-the-complications-of-diabetes
#9
Zoltán Vokó, Katalin Gáspár, András Inotai, Csaba Horváth, Katalin Bors, Gábor Speer, Zoltán Kaló
RATIONALE, AIMS, AND OBJECTIVES: To compare the effect of osteoporotic fractures and complications of diabetes mellitus on quality of life (QoL). METHOD: A cross-sectional study was performed in 840 patients with osteoporosis and in 943 patients with diabetes in Hungary to estimate the effect of osteoporotic fractures and microvascular and macrovascular complications of diabetes on QoL using the EQ-5D questionnaire. Ordinary least-squares regression was performed for the analysis to control for age and gender...
September 12, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28894793/infiltrative-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-treated-with-a-single-high-dose-y90-radioembolization-and-subsequent-liver-transplantation-without-a-recurrence
#10
Meaghan S Dendy, Juan C Camacho, Johannes M Ludwig, Alyssa M Krasinskas, Stuart J Knechtle, Hyun S Kim
BACKGROUND: Infiltrative hepatocellular carcinoma with macrovascular invasion is a relatively rare presentation and usually fatal disease. METHODS: Both patients exceeded Milan and University of California-San Francisco (UCSF) criteria, and per Barcelona Clinic Liver Cancer group guidelines, they were enrolled in a prospective open-label radioembolization phase II trial that gave them optimized lobar doses of Yttrium-90 as solely the first-line therapy without concomitant or additional pharmacological or locoregional therapies...
September 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28890350/thioredoxin-interacting-protein-promotes-high-glucose-induced-macrovascular-endothelial-dysfunction
#11
Xiaoyu Li, Karen L Kover, Daniel P Heruth, Dara J Watkins, Yanchun Guo, Wayne V Moore, Luke G He, Mengwei Zang, Mark A Clements, Yun Yan
Thioredoxin-interacting protein (TXNIP) emerges as a central regulator for glucose homeostasis, which goes awry in diabetic subjects. Endothelial dysfunction is considered the earliest detectable stage of cardiovascular disease (CVD), a major complication of diabetes. Here, we hypothesize that TXNIP may promote endothelial dysfunction seen in Type 1 diabetes mellitus (T1D). Using a T1D-like rat model, we found that diabetic rats showed significantly higher TXNIP mRNA and protein levels in peripheral blood, compared to their non-diabetic counterparts...
September 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28887409/longitudinal-change-in-fasting-blood-glucose-and-myocardial-infarction-risk-in-a-population-without-diabetes
#12
Cheng Jin, Shuohua Chen, Anand Vaidya, Yuntao Wu, Zhijun Wu, Frank B Hu, Penny Kris-Etherton, Shouling Wu, Xiang Gao
OBJECTIVE: To examine the change in fasting blood glucose (FBG) during repeated assessments over time and its potential impact on the risk of developing myocardial infarction (MI). RESEARCH DESIGN AND METHODS: This prospective cohort study included 68,297 participants without diabetes (mean age 49 years) who were free of MI, stroke, and cancer prior to or in 2010 (baseline of the current analysis). FBG concentrations were measured in 2006, 2008, and 2010. The FBG trajectories during 2006-2010, the primary exposure of the current study, were identified by latent mixture modeling...
September 8, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28881497/therapies-for-advanced-stage-hepatocellular-carcinoma-with-macrovascular-invasion-or-metastatic-disease-a-systematic-review-and-meta-analysis
#13
REVIEW
Richard S Finn, Andrew X Zhu, Farah Wigdan, Jehad Almasri, Feras Zaiem, Larry J Prokop, Mohammad Hassan Murad, Khaled Mohammed
Hepatocellular carcinoma (HCC) is a complex disease most commonly arising in the background of chronic liver disease. In the past two decades there has been a significant increase in our understanding of both the clinical and molecular heterogeneity of HCC. There has been a robust increase in clinical trial activity in patients with poor prognostic factors such as macrovascular invasion and extrahepatic spread. We aimed to synthesize the evidence for the treatment of patients with advanced HCC based on these baseline characteristics including patients with both Child-Pugh scores of A and B...
September 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28878941/clinical-profiles-comorbidities-and-complications-of-type-2-diabetes-mellitus-in-patients-from-united-arab-emirates
#14
Herbert F Jelinek, Wael M Osman, Ahsan H Khandoker, Kinda Khalaf, Sungmun Lee, Wael Almahmeed, Habiba S Alsafar
OBJECTIVE: To assess clinical profiles of patients with type 2 diabetes in the United Arab Emirates (UAE), including patterns, frequencies, and risk factors of microvascular and macrovascular complications. RESEARCH DESIGN AND METHODS: Four hundred and ninety patients with type 2 diabetes were enrolled from two major hospitals in Abu Dhabi. The presence of microvascular and macrovascular complications was assessed using logistic regression, and demographic, clinical and laboratory data were collected...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28869249/glp-1-and-the-kidney-from-physiology-to-pharmacology-and-outcomes-in-diabetes
#15
REVIEW
Marcel H A Muskiet, Lennart Tonneijck, Mark M Smits, Michaël J B van Baar, Mark H H Kramer, Ewout J Hoorn, Jaap A Joles, Daniël H van Raalte
The gastrointestinal tract - the largest endocrine network in human physiology - orchestrates signals from the external environment to maintain neural and hormonal control of homeostasis. Advances in understanding entero-endocrine cell biology in health and disease have important translational relevance. The gut-derived incretin hormone glucagon-like peptide 1 (GLP-1) is secreted upon meal ingestion and controls glucose metabolism by modulating pancreatic islet cell function, food intake and gastrointestinal motility, amongst other effects...
September 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28842165/chronic-kidney-disease-basal-insulin-glargine-and-health-outcomes-in-people-with-dysglycemia-the-origin-study
#16
Vasilios Papademetriou, Eric S Nylen, Michael Doumas, Jeff Probstfield, Johannes F E Mann, Richard E Gilbert, Hertzel C Gerstein
BACKGROUND: Early stages of chronic kidney disease are associated with an increased cardiovascular risk in patients with established type 2 diabetes and macrovascular disease. The role of early stages of chronic kidney disease on macrovascular outcomes in prediabetes and early type two diabetes mellitus is not known. In the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial, the introduction of insulin had no effect on cardiovascular outcomes compared to standard therapy...
August 22, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28837695/a-physiological-model-for-interpretation-of-arterial-spin-labeling-reactive-hyperemia-of-calf-muscles
#17
Hou-Jen Chen, Graham A Wright
To characterize and interpret arterial spin labeling (ASL) reactive hyperemia of calf muscles for a better understanding of the microcirculation in peripheral arterial disease (PAD), we present a physiological model incorporating oxygen transport, tissue metabolism, and vascular regulation mechanisms. The model demonstrated distinct effects between arterial stenoses and microvascular dysfunction on reactive hyperemia, and indicated a higher sensitivity of 2-minute thigh cuffing to microvascular dysfunction than 5-minute cuffing...
2017: PloS One
https://www.readbyqxmd.com/read/28829810/extracellular-overhydration-linked-with-endothelial-dysfunction-in-the-context-of-inflammation-in-haemodialysis-dependent-chronic-kidney-disease
#18
Nicos Mitsides, Tom Cornelis, Natascha J H Broers, Nanda M P Diederen, Paul Brenchley, Frank M van der Sande, Casper G Schalkwijk, Jeroen P Kooman, Sandip Mitra
BACKGROUND: Haemodialysis (HD) patients are predisposed to dysregulated fluid balance leading to extracellular water (ECW) expansion. Fluid overload has been closely linked with outcome in these patients. This has mainly been attributed to cardiac volume overload, but the relation between abnormalities in fluid status with micro- and macrovascular dysfunction has not been studied in detail. We studied the interaction of macro- and microvascular factors in states of normal and over- hydration in HD-dependent CKD...
2017: PloS One
https://www.readbyqxmd.com/read/28822958/therapeutic-molecules-against-type-2-diabetes-what-we-have-and-what-are-we-expecting
#19
REVIEW
Ashwini Kumar, Sudhanshu Kumar Bharti, Awanish Kumar
World Health Organization (WHO) has identified diabetes as one of the fastest growing non-communicable diseases with 422 million patients around the world in 2014. Diabetes, a metabolic disease, is characterized primarily by hyperglycemia which results in various macrovascular and microvascular complications like cardiovascular disease and neuropathies which can significantly deteriorate the quality of life. The body either does not manufactures enough insulin (type 1 diabetes or T1DM) or becomes insensitive to physiologically secreted insulin or both (type 2 diabetes or T2DM)...
April 9, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28816594/consensus-statement-on-current-and-emerging-methods-for-the-diagnosis-and-evaluation-of-cerebrovascular-disease
#20
Manus J Donahue, Eric Achten, Petrice M Cogswell, Frank-Erik De Leeuw, Colin P Derdeyn, Rick M Dijkhuizen, Audrey P Fan, Rashid Ghaznawi, Jeremy J Heit, M Arfan Ikram, Peter Jezzard, Lori C Jordan, Eric Jouvent, Linda Knutsson, Richard Leigh, David S Liebeskind, Weili Lin, Thomas W Okell, Adnan I Qureshi, Charlotte J Stagg, Matthias Jp van Osch, Peter Cm van Zijl, Jennifer M Watchmaker, Max Wintermark, Ona Wu, Greg Zaharchuk, Jinyuan Zhou, Jeroen Hendrikse
Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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