keyword
MENU ▼
Read by QxMD icon Read
search

Macrovascular disease

keyword
https://www.readbyqxmd.com/read/29773079/effects-of-linagliptin-on-endothelial-function-and-postprandial-lipids-in-coronary-artery-disease-patients-with-early-diabetes-a-randomized-placebo-controlled-double-blind-trial
#1
Norbert J Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner, Harald Sourij
BACKGROUND: Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovascular outcome trials are performed in subjects with manifest atherosclerosis and long-standing diabetes. Therefore, the aim of this study is to investigate the effects of the dipeptidylpeptidase-4 inhibitor linagliptin in subjects with coronary artery disease (CAD) but early type 2 diabetes mellitus (T2DM) on a set of cardiovascular surrogate measurements...
May 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29772547/role-of-alpha1-adrenergic-receptor-antibodies-in-alzheimer-s-disease
#2
Peter Karczewski, Petra Hempel, Marion Bimmler
Agonistic autoantibodies (agAAB) for alpha-1 adrenoceptor were found in approx. 50% of patients with Alzheimer's disease. These antibodies activate the receptor and trigger the signal cascades similarly to how natural agonists do. The agAAB bond to the receptor is persistent and prolonged. This results in a non-physiological elevation of intracellular calcium. An animal model has shown that agAAB causes macrovascular and microvascular impairment in the vessels of the brain. Reduction in blood flow and the density of intact vessels was significantly demonstrated...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29753399/cardiovascular-disease-and-diabetic-kidney-disease
#3
REVIEW
Muhammad Maqbool, Mark E Cooper, Karin A M Jandeleit-Dahm
Diabetic kidney disease commonly is associated with an increased risk of cardiovascular disease. There are traditional common risk factors for both conditions including hypertension and poor glycemic control. However, it is likely that there are other pathophysiological mechanisms that explain the clinical phenomenon of increased cardiovascular disease in diabetic patients with chronic kidney and vice versa. Current management of both conditions includes aggressive glucose and blood pressure control. The protective role of treating dyslipidemia has been shown for cardiovascular disease, but the results for renal disease are not as clear...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29738868/bsmi-single-nucleotide-polymorphism-in-vitamin-d-receptor-gene-is-associated-with-decreased-circulatory-levels-of-serum-25-hydroxyvitamin-d-among-micro-and-macrovascular-complications-of-type-2-diabetes-mellitus
#4
Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay
Vitamin D Receptor (VDR) gene single nucleotide polymorphism (SNP) in the intron 8 is a well characterized SNP which has previously been linked to various diseases including Type 2 Diabetes Mellitus (T2DM). However, the association of this SNP with micro and macrovascular complications of T2DM remains poorly studied. Hence, the present study was designed to investigate the association of VDR gene SNP with complications of T2DM (disease phenotype) and correlated it with the serum levels of (25[OH]D) (intermediate phenotype) along with other clinical risk factors of T2DM...
May 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29737267/role-of-ampk-in-diabetic-cardiovascular-complications-an-overview
#5
Ashutosh Kumar, Karthika Nellaiappan, Veera Ganesh Yerra
Macrovascular complications of diabetes like cardiovascular diseases appear to be one of the leading causes of mortality. Current therapies aimed at counteracting the adverse effects of diabetes on cardiovascular system are found to be inadequate. Hence, there is growing need in search of novel targets. Adenosine monophosphate activated protein kinase (AMPK) is one such promising target, as a plethora of evidences point to its cardioprotective role in pathological milieu like cardiac hypertrophy, atherosclerosis and heart failure...
May 7, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29737256/cardiovascular-effects-of-liraglutide
#6
Nasser Mikhail
BACKGROUND: Liraglutide is a glucagon-like 1 (GLP-1) agonist approved for treatment of type 2 diabetes and obesity. OBJECTIVE: To review the cardiovascular effects of liraglutide including macrovascular and microvascular events, its use in heart failure, and its effects on heart rate and blood pressure. RESULTS: The impact of liraglutide on cardiovascular outcomes was examined in a large well-designed study published in 2016, the LEADER trial...
May 7, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29731925/serum-apelin-a-new-marker-of-early-atherosclerosis-in-children-with-type-1-diabetes-mellitus
#7
Rania N Sabry, Maged A El Wakeel, Ghada M El-Kassas, Ahmed F Amer, Wael H El Batal, Salwa Refat El-Zayat, Mohamed Abou-El-Asrar
INTRODUCTION: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be complicated by micro or macrovascular complications. Measurement of the carotid intima-media thickness (CIMT) allows the early detection of atherosclerotic alterations of blood vessels that may complicate T1DM. SUBJECTS AND METHODS: This study is a case-control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29728717/circulating-amino-acids-and-the-risk-of-macrovascular-microvascular-and-mortality-outcomes-in-individuals-with-type-2-diabetes-results-from-the-advance-trial
#8
Paul Welsh, Naomi Rankin, Qiang Li, Patrick B Mark, Peter Würtz, Mika Ala-Korpela, Michel Marre, Neil Poulter, Pavel Hamet, John Chalmers, Mark Woodward, Naveed Sattar
AIMS/HYPOTHESES: We aimed to quantify the association of individual circulating amino acids with macrovascular disease, microvascular disease and all-cause mortality in individuals with type 2 diabetes. METHODS: We performed a case-cohort study (N = 3587), including 655 macrovascular events, 342 microvascular events (new or worsening nephropathy or retinopathy) and 632 all-cause mortality events during follow-up, in a secondary analysis of the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) study...
May 4, 2018: Diabetologia
https://www.readbyqxmd.com/read/29726089/diabetic-foot-syndrome-dfs-in-patients-with-diabetes-a-multicenter-german-austrian-dpv-analysis-on-33-870-dfs-patients-among-358-986-adult-subjects-with-diabetes
#9
Barbara Bohn, Arthur Grünerbel, Marcus Altmeier, Carsten Giesche, Martin Pfeifer, Christian Wagner, Nikolai Heise, Frank Best, Peter Fasching, Reinhard W Holl
AIMS: The diabetic foot syndrome (DFS) is a serious complication in patients with diabetes increasing the risk for minor/major amputations. This analysis aimed to examine differences in diabetes patients with or without DFS stratified by type 1 (T1D) or type 2 diabetes (T2D). MATERIAL AND METHODS: Adult patients (≥20y of age) with diabetes from the German/Austrian DPV-registry were included. The cross-sectional study comprised 45,722 subjects with T1D (nDFS =2,966) and 313,264 with T2D (nDFS =30,904)...
May 3, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29724198/the-synergistic-effects-of-saxagliptin-and-metformin-on-cd34-endothelial-progenitor-cells-in-early-type-2-diabetes-patients-a-randomized-clinical-trial
#10
Fiona J Dore, Cleyton C Domingues, Neeki Ahmadi, Nabanita Kundu, Yana Kropotova, Sara Houston, Carol Rouphael, Aytan Mammadova, Linda Witkin, Anamil Khiyami, Richard L Amdur, Sabyasachi Sen
AIMS: Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be used as a cardiovascular disease risk biomarker. This study investigated whether the addition of saxagliptin, a DPP-IV inhibitor, to metformin, may reduce cardiovascular disease risk in addition to improving glycemic control in Type 2 diabetes patients. METHODS: In 12 week, double-blind, randomized placebo-controlled trial, 42 subjects already taking metformin 1-2 grams/day were randomized to placebo or saxagliptin 5 mg...
May 3, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29723866/prognostic-factors-associated-with-postprogression-survival-in-advanced-hepatocellular-carcinoma-patients-treated-with-sorafenib-not-eligible-for-second-line-regorafenib-treatment
#11
Teiji Kuzuya, Masatoshi Ishigami, Yoji Ishizu, Takashi Honda, Kazuhiko Hayashi, Tetsuya Ishikawa, Isao Nakano, Yoshiki Hirooka, Hidemi Goto
OBJECTIVES: The aim of this study was to investigate the prognostic factors associated with postprogression survival (PPS) in advanced hepatocellular carcinoma (HCC) patients treated with sorafenib, who were not eligible for second-line treatment with regorafenib. METHODS: A total of 103 patients with radiological confirmation of progressive disease (PD) were enrolled. RESULTS: The median PPS (n = 67) was 6.1 months. Significant and independent prognostic factors at initial radiological PD associated with good PPS were an Eastern Cooperative Oncology Group Performance Status (ECOG-PS) score of 0, the absence of macrovascular invasion (MVI), and time to progression (TTP) ≥4 months...
May 3, 2018: Oncology
https://www.readbyqxmd.com/read/29713471/recent-novel-approaches-to-limit-oxidative-stress-and-inflammation-in-diabetic-complications
#12
REVIEW
Raelene J Pickering, Carlos J Rosado, Arpeeta Sharma, Shareefa Buksh, Mitchel Tate, Judy B de Haan
Diabetes is considered a major burden on the healthcare system of Western and non-Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro- and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism-based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29707902/the-impact-of-cognitive-impairment-in-dementia-on-self-care-domains-in-diabetes-mellitus-a-systematic-search-and-narrative-review
#13
REVIEW
Tamsin Santos, Janaka Lovell, Kerrie Shiell, Marilyn Johnson, Joseph E Ibrahim
INTRODUCTION: Self-management is integral to effective chronic disease management. Cognitive impairments (CogImp) associated with dementia have not previously been reviewed in diabetes mellitus (DM) self-care. AIM: (i) Whether CogImp associated with dementia impact self-care. (ii) Whether specific CogImp affects key DM self-care processes. METHOD: A systematic literature search with a narrative review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
April 29, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29705998/photoacoustic-imaging-system-visualizes-restoration-of-peripheral-oxygenation-in-psoriatic-lesions
#14
Y Ishida, A Otsuka, T Honda, Y Asao, H Sekiguchi, A Yoshikawa, T Yagi, K Kabashima
Photoacoustic imaging (PAI) is an emerging technology that enables visualization of vasculatures and pigmented tissue in vivo1 . PAI has been used for the detection of cancers such as melanoma, thyroid cancer and breast cancer in pre-clinical studies2,3 . To date, no study has used PAI to assess a systemic, internal disease. Many systemic diseases such as hypertension and diabetes cause atherosclerosis (a macrovascular disease) and arteriosclerosis (a microvascular disease). While atherosclerosis is readily evaluated by clinical tests such as sonographic study of the common carotid arteries, arteriosclerosis cannot be readily assessed...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29704920/hypertension-in-patients-with-type-2-diabetes-mellitus-targets-and-management
#15
REVIEW
Dimitra I Pavlou, Stavroula Α Paschou, Panagiotis Anagnostis, Michael Spartalis, Eleftherios Spartalis, Andromachi Vryonidou, Nicholas Tentolouris, Gerasimos Siasos
Two-thirds of patients with type 2 diabetes mellitus (T2DM) have arterial hypertension. Hypertension increases the incidence of both micro- and macrovascular complications in these patients, while the co-existence of these two major risk factors leads to a four-fold increased risk for cardiovascular disease (CVD) compared with normotensive non-diabetic controls. The aim of this article is to comprehensively review the literature and present updated information on targets for blood pressure (BP) and on the management of hypertension in patients with T2DM...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29694948/baseline-high-sensitivity-c-reactive-protein-predicts-macrovascular-and-microvascular-complications-of-type-2-diabetes-a-population-based-study
#16
Zahra Aryan, Alireza Ghajar, Sara Faghihi-Kashani, Mohsen Afarideh, Manouchehr Nakhjavani, Alireza Esteghamati
BACKGROUND/AIMS: This prospective study is aimed at examining the predictive value of high-sensitivity C-reactive protein (hs-CRP) for coronary heart disease (CHD) events and microvascular complications of type 2 diabetes mellitus (T2DM). METHODS: A population-based study (NCT02958579) was conducted on 1,301 participants with T2DM (mean follow-up of 7.5 years). Risk assessment for vascular events was done at baseline, and serum hs-CRP was measured. End points of this study include CHD events, diabetic retinopathy, neuropathy, and diabetic kidney disease...
April 25, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29682103/cardiovascular-disease-in-japanese-patients-with-type-2-diabetes-mellitus
#17
REVIEW
Kazuya Fujihara, Hirohito Sone
Individuals with diabetes have a two- to four-fold increased risk of coronary artery disease (CAD) and higher mortality rates than those without diabetes. Because not only microvascular but also macrovascular disease in patients with diabetes are known to predispose patients to a lower quality of life as well as lead to higher mortality rates, identifying and managing risk factors of CAD is of clinical relevance in diabetes care. A number of antihyperglycemic drugs are currently approved for the treatment of hyperglycemia in patients with type 2 diabetes mellitus (T2DM), with several new drugs having been developed during the last decade...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29678824/metabolic-karma-the-atherogenic-legacy-of-diabetes-the-2017-edwin-bierman-award-lecture
#18
Mark Emmanuel Cooper, Assam El-Osta, Terri Jean Allen, Anna Margareta Dorothea Watson, Merlin Christopher Thomas, Karin Agnes Maria Jandeleit-Dahm
Cardiovascular disease, despite all the recent advances in treatment of the various risk factors, remains the major cause of mortality in both type 1 and type 2 diabetes. Experimental models of diabetes-associated atherosclerosis, despite their limitations in recapitulating the human context, have assisted in the elucidation of molecular and cellular pathways implicated in the development and progression of macrovascular injury in diabetes. Our own studies have emphasized the role of oxidative stress and advanced glycation and identified potential targets for vasoprotective therapies in the setting of diabetes...
May 2018: Diabetes
https://www.readbyqxmd.com/read/29677463/a-role-for-collagen-iv-in-cardiovascular-disease
#19
Lasse Bach Steffensen, Lars M Rasmussen
Over the past decade, studies have repeatedly found single nucleotide polymorphisms located in the COL4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of approximately 160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the ⍺1- and ⍺2-chains of collagen IV, a major component of basement membranes in various tissues including arteries. In spite of the growing body of evidence indicating a role for collagen IV in CVD, remarkably few studies aim at directly investigating such a role...
April 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29675479/associations-of-diabetic-retinopathy-with-retinal-neurodegeneration-on-the-background-of-diabetes-mellitus-overview-of-recent-medical-studies-with-an-assessment-of-the-impact-on-healthcare-systems
#20
Rafał Muc, Agnieszka Saracen, Iwona Grabska-Liberek
Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Diabetes Mellitus, Diabetic Retinopathy and Diabetic Retinal Neuropathy are closely related diseases - originating from incorrectly controlled glycemia, blood pressure and lipid levels in the course of increasing resistance of the body tissues to insulin...
2018: Open Medicine (Warsaw, Poland)
keyword
keyword
88641
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"