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Interrupted Time Series

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https://www.readbyqxmd.com/read/29792971/impact-of-active-surveillance-and-infection-control-measures-on-carbapenem-resistant-gram-negative-bacterial-colonization-and-infections-in-intensive-care
#1
T Karampatakis, K Tsergouli, E Iosifidis, C Antachopoulos, A Karapanagiotou, A Karyoti, N Gritsi-Gerogianni, A Tsakris, E Roilides
BACKGROUND: Carbapenem-resistant Gram-negative bacteria (CRGNB) infections constitute a global threat for critically ill patients and the outcome of their hospitalization. Early identification of CRGNB through rectal surveillance cultures and routine infection control measures including contact precautions, use of appropriate disinfectants, staff education on cleaning, and hand hygiene may reduce the dissemination of CRGNB. AIM: To assess the impact of enhanced infection control measures on CRGNB infections in a nine-bed polyvalent intensive care unit in a tertiary level hospital in an endemic area...
May 21, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29788455/a-10-yr-analysis-of-chronic-pelvic-pain-and-chronic-opioid-therapy-in-the-women-veteran-population
#2
Sara B Cichowski, Rebecca G Rogers, Yuko Komesu, Erin Murata, Clifford Qualls, Allison Murata, Glen Murata
Introduction: Chronic pelvic pain (CPP) affects an estimated 30% of women Veterans. Previous research shows high rates of narcotic abuse in the women Veteran population. Narcotics are not recommended for the treatment of CPP. Understanding how CPP impacts narcotic prescribing in the women Veteran population is critical to addressing the public health crisis of opioid abuse. Our objective was to compare chronic opioid therapy (COT) prescribed 5 yr prior to and following CPP diagnosis and to identify predictors of COT as well as adverse events associated with COT...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29788203/do-cost-containment-policies-save-money-and-influence-physicians-prescribing-behavior-lessons-from-south-korea-s-drug-policy-for-diabetes-medication
#3
Shin-On Kang, Seung Ju Kim, Sohee Park, Sung-In Jang, Eun-Cheol Park
Objective: We evaluate the effects of drug price reduction policy on pharmaceutical expenditure and prescription patterns in diabetes medication. Design: An interrupted time series study design using generalized estimating equations. Setting: This study used National Health Insurance claim data from 2010 to 2013. Participants: A total of 68 127 diabetes patients and 12 465 hospitals. Intervention(s): The drug price reduction policy...
May 17, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29785569/association-between-firearm-laws-and-homicide-in-urban-counties
#4
Cassandra K Crifasi, Molly Merrill-Francis, Alex McCourt, Jon S Vernick, Garen J Wintemute, Daniel W Webster
Laws related to the sale, use, and carrying of firearms have been associated with differences in firearm homicide rates at the state level. Right-to-carry (RTC) and stand your ground (SYG) laws are associated with increases in firearm homicide; permit-to-purchase (PTP) laws and those prohibiting individuals convicted of violent misdemeanors (VM) have been associated with decreases in firearm homicide. Evidence for the effect of comprehensive background checks (CBC) not tied to PTP is inconclusive. Because firearm homicide tends to concentrate in urban areas, this study was designed to test the effects of firearm laws on homicide in large, urban U...
May 21, 2018: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29778769/mandatory-review-of-a-prescription-drug-monitoring-program-and-impact-on-opioid-and-benzodiazepine-dispensing
#5
Erin L Winstanley, Yifan Zhang, Rebecca Mashni, Sydney Schnee, Jonathan Penm, Jill Boone, Cameron McNamee, Neil J MacKinnon
BACKGROUND: The purpose of this study is to determine whether Ohio House Bill 341, which mandated the use of Ohio's Prescription Drug Monitoring Program (PDMP), was an effective regulatory strategy to reduce opioid and benzodiazepine dispensing. METHOD: Secondary analysis of Ohio's PDMP data on prescription opioids and benzodiazepines dispensed from November 2014 to March 2017. An interrupted time series analysis was conducted to determine if there was a significant change in the quantity of opioids and benzodiazepines dispensed...
May 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29770874/electronic-voting-to-improve-morbidity-and-mortality-conferences
#6
Joel Zindel, Reto M Kaderli, Manuel O Jakob, Michel Dosch, Franziska Tschan, Daniel Candinas, Guido Beldi
BACKGROUND: It is of major importance in clinical surgery to identify potential patterns and specific causes of complications. Therefore, morbidity and mortality meetings (M&M) are widely used to discuss and evaluate deviations from expected outcomes in order to improve surgical practice. Moreover, M&M represent an important tool for continuous medical education. In this study, we introduced an electronic voting system to assess whether anonymity during M&M could limit potential biases due to hierarchical structures or opinion leaders...
May 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29768584/mortality-from-type-2-diabetes-and-implementation-of-the-prevenimss-program-a-time-series-study-in-mexico-1998-2015
#7
Oswaldo Sinoe Medina-Gómez, Ismael Seth Medina-Reyes
Type 2 diabetes is the leading cause of morbidity and mortality in the world. In Mexico it is the first cause of mortality, disability, and potential years of life lost due to premature death. The Mexican Institute of Social Security (IMSS) implemented the PREVENIMSS strategy. The aim of the current study was to estimate the program's effect on the mortality trend from type 2 diabetes, based on an interrupted time series analysis. At the beginning of the target period, the diabetes mortality rate was higher in IMSS beneficiaries than in the control population...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29767700/effects-of-iodized-salt-and-iodine-supplements-on-prenatal-and-postnatal-growth-a-systematic-review
#8
Jessica Farebrother, Celeste E Naude, Liesl Nicol, Zhongna Sang, Zhenyu Yang, Pieter L Jooste, Maria Andersson, Michael B Zimmermann
Hypothyroidism due to iodine deficiency can impair physical development, most visibly in the marked stunting of myxedematous cretinism caused by severe in utero iodine deficiency. Whether iodine repletion improves growth in noncretinous children is uncertain. Therefore, the aim of our systematic review was to assess the effects of iodine fortification or supplementation on prenatal and postnatal growth outcomes in noncretinous children. Following Cochrane methods and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) reporting guidelines, we searched 10 databases including 2 Chinese databases (latest search February 2017)...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29767478/the-effect-of-share-35-on-biliary-complications-an-interrupted-time-series-analysis
#9
J N Fleming, D J Taber, D Axelrod, K D Chavin
The purpose of the Share 35 allocation policy was to improve liver transplant waitlist mortality, targeting high MELD waitlisted patients. However, policy changes may also have unintended consequences that must be balanced with the primary desired outcome. We performed an interrupted time series assessing the impact of Share 35 on biliary complications in a select national liver transplant population using the Vizient CDB/RM™ database. Liver transplants that occurred between October 2012 and September 2015 were included...
May 16, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29763508/withdrawn-nursing-record-systems-effects-on-nursing-practice-and-healthcare-outcomes
#10
REVIEW
Christine Urquhart, Rosemary Currell, Maria J Grant, Nicholas R Hardiker
BACKGROUND: A nursing record system is the record of care that was planned or given to individual patients and clients by qualified nurses or other caregivers under the direction of a qualified nurse. Nursing record systems may be an effective way of influencing nurse practice. OBJECTIVES: To assess the effects of nursing record systems on nursing practice and patient outcomes. SEARCH METHODS: For the original version of this review in 2000, and updates in 2003 and 2008, we searched: the Cochrane Effective Practice and Organisation of Care (EPOC) Group Specialised Register; MEDLINE, EMBASE, CINAHL, BNI, ISI Web of Knowledge, and ASLIB Index of Theses...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29759380/impact-of-a-clinical-interventions-bundle-on-uptake-of-hpv-vaccine-at-an-ob-gyn-clinic
#11
Uma Deshmukh, Carlos R Oliveira, Susan Griggs, Emily Coleman, Lital Avni-Singer, Shefali Pathy, Eugene D Shapiro, Sangini S Sheth
INTRODUCTION: HPV vaccine uptake is lowest among young adults. Little is known about the most effective way to decrease missed opportunities (MO) and increase uptake of the vaccine in this vulnerable population. OBJECTIVES: To determine the impact of a clinical intervention bundle on the rate of MO and uptake of the vaccine among young adult women. METHODS: From 2/2014 to 7/2015, an intervention bundle (designating physician and nurse champions, pre-screening patients' charts, empowering nurses to recommend immunization, providing no-cost vaccinations, placing prompts in clinic note templates, eliminating requirement for pre-vaccination pregnancy test) was implemented at an urban, hospital-based OB/GYN clinic...
May 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29755704/breastfeeding-in-patients-with-chronic-myeloid-leukaemia-case-series-with-measurements-of-drug-concentrations-in-maternal-milk-and-literature-review
#12
Ekaterina Chelysheva, Sergey Aleshin, Evgenia Polushkina, Roman Shmakov, Igor Shokhin, Ghermes Chilov, Anna Turkina
Breastfeeding in patients with chronic myeloid leukaemia (CML) during tyrosine kinase inhibitors (TKIs) therapy is not recommended but interruption of TKI treatment may cause the loss of remission. We studied the 3 cases of pregnancy and breastfeeding in women with CML and observed that stopping treatment without major molecular response may end in haematological relapse. The concentrations of nilotinib and imatinib in maternal milk were measured and nilotinib distribution in human breast milk was demonstrated for the first time...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29754458/integrating-point-of-care-testing-into-a-community-emergency-department-a-mixed-methods-evaluation
#13
Jesse M Pines, Mark S Zocchi, Caitlin Carter, Charles Z Marriott, Matthew Bernard, Leah H Warner
STUDY OBJECTIVE: Point-of-care testing (POCT) is a commonly used technology that hastens the time to laboratory results in emergency departments (ED). We evaluated an ED-based POCT program on ED length of stay and time to care, coupled with qualitative interviews of local ED stakeholders. METHODS: We conducted a mixed-methods study (2012-16) to examine the impact of point-of-care testing in a single, community ED. The quantiative analysis involved an observational before-after study comparing time to laboratory test result (POC troponin or POC chemistry) and ED length of stay after implementation of POCT, using a propensity-weighted interrupted time series analysis (ITSA)...
May 13, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29749091/using-forecast-modelling-to-evaluate-treatment-effects-in-single-group-interrupted-time-series-analysis
#14
Ariel Linden
RATIONALE, AIMS, AND OBJECTIVES: Interrupted time series analysis (ITSA) is an evaluation methodology in which a single treatment unit's outcome is studied serially over time and the intervention is expected to "interrupt" the level and/or trend of that outcome. ITSA is commonly evaluated using methods which may produce biased results if model assumptions are violated. In this paper, treatment effects are alternatively assessed by using forecasting methods to closely fit the preintervention observations and then forecast the post-intervention trend...
May 11, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29737522/interventions-for-improving-adherence-to-iron-chelation-therapy-in-people-with-sickle-cell-disease-or-thalassaemia
#15
REVIEW
Patricia M Fortin, Sheila A Fisher, Karen V Madgwick, Marialena Trivella, Sally Hopewell, Carolyn Doree, Lise J Estcourt
BACKGROUND: Regularly transfused people with sickle cell disease (SCD) and people with thalassaemia (who are transfusion-dependent or non-transfusion-dependent) are at risk of iron overload. Iron overload can lead to iron toxicity in vulnerable organs such as the heart, liver and endocrine glands; which can be prevented and treated with iron chelating agents. The intensive demands and uncomfortable side effects of therapy can have a negative impact on daily activities and well-being, which may affect adherence...
May 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29728447/investigating-the-association-of-alerts-from-a-national-mortality-surveillance-system-with-subsequent-hospital-mortality-in-england-an-interrupted-time-series-analysis
#16
Elizabeth Cecil, Alex Bottle, Aneez Esmail, Samantha Wilkinson, Charles Vincent, Paul P Aylin
OBJECTIVE: To investigate the association between alerts from a national hospital mortality surveillance system and subsequent trends in relative risk of mortality. BACKGROUND: There is increasing interest in performance monitoring in the NHS. Since 2007, Imperial College London has generated monthly mortality alerts, based on statistical process control charts and using routinely collected hospital administrative data, for all English acute NHS hospital trusts...
May 4, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29727997/from-floodplain-to-aquatic-sediments-radiogeochronological-fingerprints-in-a-sediment-core-from-the-mining-impacted-sancho-reservoir-sw-spain
#17
J M Abril, E G San Miguel, C Ruiz-Canovas, M Casas-Ruiz, J P Bolívar
The Sancho Reservoir (SW Spain) was built in 1962, about the time of maximum 137 Cs fallout, and it has been affected by acid mine drainage (AMD) particularly since the mining cease in 2001. This is a unique scenario for studying the radiogeochronological fingerprints in AMD-affected sediments deposited over the former flood plain. A sediment core sampled in 2011 was analysed for bulk density, 137 Cs, 239 Pu, 240 Pu, 210 Pb, 226 Ra, 228 Ra, 234 Th (238 U) and 40 K, and studied with various radiometric dating models...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29724205/impact-of-a-direct-to-consumer-information-campaign-on-prescription-patterns-for-overactive-bladder
#18
Masayoshi Zaitsu, Byung-Kwang Yoo, Jun Tomio, Fumiaki Nakamura, Satoshi Toyokawa, Yasuki Kobayashi
BACKGROUND: Direct-to-consumer information (DTCI) campaign is a new medium to inform and empower patients in their decision-making without directly promoting specific drugs. However, little is known about the impact of DTCI campaigns, expanding rapidly in developed countries, on changes in prescription patterns. We sought to determine whether a DTCI campaign on overactive bladder increases the prescription rate for overactive bladder treatment drugs. METHODS: We performed a 3-year retrospective cohort study of 1332 participants who were diagnosed overactive bladder but not prescribed treatment drugs prior to the examined DTCI campaign (exposure), using the health insurance claims dataset of the Japan Medical Data Center (November 19, 2010 to November 18, 2013)...
May 3, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29720908/implementation-and-impact-of-an-antimicrobial-stewardship-program-at-a-non-freestanding-children-s-hospital
#19
J Michael Klatte, Kathleen Kopcza, Alexander Knee, Evan R Horton, Erica Housman, Donna J Fisher
OBJECTIVES: Pediatric Antimicrobial Stewardship Programs (ASP) have been associated with improvements in antibiotic utilization and patient outcomes; however, ASP studies originating from non-freestanding children's hospitals are lacking. In this study, we present the implementation and impact of a multidisciplinary ASP that employs a collaborative physician and pharmacist driven thrice-weekly prospective audit-with-feedback approach at a non-freestanding children's hospital. METHODS: Implementation was assessed via descriptive design...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29720247/interventions-for-improving-pharmacist-led-patient-counselling-in-the-community-setting-a-systematic-review
#20
Sinaa Al Aqeel, Norah Abanmy, Hiba AlShaya, Albatoul Almeshari
BACKGROUND: Pharmacist counselling is an important service that has been associated with improved outcomes. The primary aim of this review was to identify, describe, and determine the effectiveness of interventions for improving the counselling practice of community pharmacists. METHODS: We searched PubMed (from January 1990 to June 2017) and the Cochrane Library (June 2017). To supplement our database searches, we searched Google Scholar for papers that cited the identified studies...
May 2, 2018: Systematic Reviews
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