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Interrupted Time Series

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https://www.readbyqxmd.com/read/28726973/heart-rate-variability-biofeedback-stress-relief-program-for-depression-a-replicated-single-subject-design
#1
Bregje M A Hartogs, Agna Bartels-Velthuis, Karen Van der Ploeg, Elske H Bos
BACKGROUND: Depressive disorders often have a chronic course and the efficacy of evidence-based treatments may be overestimated. OBJECTIVE: To examine the effectiveness of the Heart Rate Variability Stress Reduction Program (SRP) as a supplement to standard treatment in patients with depressive disorders. METHODS: The SRP was individually administered in eight weekly sessions. Seven participants completed the full protocol and were enrolled in a single-subject ABA multiple baseline experimental design...
July 19, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28725791/quality-improvement-intervention-for-reduction-of-redundant-testing
#2
Alan M Ducatman, Danyel H Tacker, Barbara S Ducatman, Dustin Long, Peter L Perrotta, Hannah Lawther, Kelly Pennington, Owen Lander, Mary Warden, Conard Failinger, Kevin Halbritter, Ronald Pellegrino, Marney Treese, Jeffrey A Stead, Eric Glass, Lauren Cianciaruso, Konrad C Nau
Laboratory data are critical to analyzing and improving clinical quality. In the setting of residual use of creatine kinase M and B isoenzyme testing for myocardial infarction, we assessed disease outcomes of discordant creatine kinase M and B isoenzyme +/troponin I (-) test pairs in order to address anticipated clinician concerns about potential loss of case-finding sensitivity following proposed discontinuation of routine creatine kinase and creatine kinase M and B isoenzyme testing. Time-sequenced interventions were introduced...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28715182/revisiting-the-helical-cooperativity-of-synthetic-polypeptides-in-solution
#3
Yuan Ren, Ryan Baumgartner, Hailin Fu, Paul van der Schoot, Jianjun Cheng, Yao Lin
Using synthetic polypeptides as a model system, the theories of helix-coil transition were developed into one of the most beautiful and fruitful subjects in macromolecular science. The classic models proposed by Schellman and Zimm-Bragg more than 50 years ago, differ in the assumption on whether the configuration of multiple helical sequences separated by random coil sections is allowed in a longer polypeptide chain. Zimm also calculated the critical chain lengths that facilitate such interrupted helices in different solvent conditions...
July 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28711691/effects-of-the-2009-medical-cannabinoid-legalization-policy-on-hospital-use-for-cannabinoid-dependency-and-persistent-vomiting
#4
Mustafa Al-Shammari, Karina Herrera, Xibei Liu, Brandon Gisi, Takashi Yamashita, Kyu-Tae Han, Mohamed Azab, Harmeet Mashiana, Muthena Maklad, Muhammad Talha Farooqui, Ranjit Makar, Ji Won Yoo
BACKGROUND & AIMS: In year of 2009, the United States federal Department of Justice issued a memo stating that it would not prosecute users and sellers who complied with the state laws allowing for medical use of marijuana. There are growing concerns about legalization of marijuana use and its related public health effects. We performed an interrupted time series analysis to evaluate these effects. METHODS: We collected a representative sample of hospital discharge data from the healthcare cost and utilization project, from January 1993 through December 2014...
July 12, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28710221/trends-in-readmission-rates-for-safety-net-hospitals-and-non-safety-net-hospitals-in-the-era-of-the-us-hospital-readmission-reduction-program-a-retrospective-time-series-analysis-using-medicare-administrative-claims-data-from-2008-to-2015
#5
Amy M Salerno, Leora I Horwitz, Ji Young Kwon, Jeph Herrin, Jacqueline N Grady, Zhenqiu Lin, Joseph S Ross, Susannah M Bernheim
OBJECTIVE: To compare trends in readmission rates among safety net and non-safety net hospitals under the US Hospital Readmission Reduction Program (HRRP). DESIGN: A retrospective time series analysis using Medicare administrative claims data from January 2008 to June 2015. SETTING: We examined 3254 US hospitals eligible for penalties under the HRRP, categorised as safety net or non-safety net hospitals based on the hospital's proportion of patients with low socioeconomic status...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28707876/fluorescence-light-up-biosensor-for-microrna-based-on-the-distance-dependent-photoinduced-electron-transfer
#6
Shasha Lu, Shuang Wang, Jiahui Zhao, Jian Sun, Xiurong Yang
It is demonstrated that miRNAs exhibit significant regulatory roles in a series of biological processes and associated with diverse human diseases. Herein, we report a convenient fluorescent biosensor for the quantitative determination of miR-21, a key miRNA related to the cardio-cerebrovascular diseases. Our proposal involves not only the rational design of single stranded DNA as the probe, successively including a C-rich sequence as the synthetic template of DNA/Ag nanoclusters (DNA/AgNCs), a complementary (Com) sequence to hybridize with the miR-21 and a G-rich sequence to form complex of G-quadruplex/hemin, but also the distance-dependent property of photoinduced electron transfer (PET) between the preformed DNA/AgNCs (electron donor) and G-quadruplex/hemin complex (electron acceptor)...
July 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28705023/helping-hospitals-improve-patient-centeredness-assessing-the-impact-of-feedback-following-a-best-practices-workshop
#7
Christoph Kowalski, William H Yeaton, Kathrin Kuhr, Holger Pfaff
Regularly reported patient surveys are an important dimension of hospital quality management. This study investigates whether providing hospital staff with interim feedback on patient survey results following a best practices workshop can help hospitals improve patient centeredness. Standardized surveys with consecutive patient samples were administered in accredited breast cancer center (BCC) hospitals in one German state (18 million inhabitants), over a 6-month period, in 2012. Two studies were conducted by applying a combination of regression point displacement (RPD) and interrupted time series (ITS) designs...
June 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/28698191/manual-versus-semiautomatic-rhythm-analysis-and-defibrillation-for-out-of-hospital-cardiac-arrest
#8
Ziad Nehme, Emily Andrew, Resmi Nair, Stephen Bernard, Karen Smith
BACKGROUND: Although manual and semiautomatic external defibrillation (SAED) are commonly used in the management of out-of-hospital cardiac arrest, the optimal strategy is not known. We hypothesized that SAED would reduce the time to first shock and lead to higher rates of cardioversion and survival compared with a manual strategy. METHODS AND RESULTS: Between July 2005 and June 2015, we included adult out-of-hospital cardiac arrest of presumed cardiac pathogenesis...
July 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28697765/deregulation-of-sale-of-over-the-counter-drugs-outside-of-pharmacies-in-the-republic-of-korea-interrupted-time-series-analysis-of-outpatient-visits-before-and-after-the-policy
#9
Sung-Youn Chun, Hye-Ki Park, Kyu-Tae Han, Woorim Kim, Hyo-Jung Lee, Eun-Cheol Park
BACKGROUND: We evaluated the effectiveness of a policy allowing for the sale of over-the-counter drugs outside of pharmacies by examining its effect on number of monthly outpatient visits for acute upper respiratory infections, dyspepsia, and migraine. METHOD: We used medical claims data extracted from the Korean National Health Insurance Cohort Database from 2009 to 2013. The Korean National Health Insurance Cohort Database comprises a nationally representative sample of claims - about 2% of the entire population - obtained from the medical record data held by the Korean National Health Insurance Corporation (which has data on the entire nation)...
July 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28694268/the-effect-of-changes-in-cervical-cancer-screening-guidelines-on-chlamydia-testing
#10
Michelle S Naimer, Jeffrey C Kwong, Deepit Bhatia, Rahim Moineddin, Michael Whelan, Michael A Campitelli, Liane Macdonald, Aisha Lofters, Ashleigh Tuite, Tali Bogler, Joanne A Permaul, Warren J McIsaac
PURPOSE: Many chlamydia infections are identified through screening, which is frequently offered to females concomitantly with cervical cancer screening. Recent cervical cancer screening guidelines recommend screening less frequently and starting later. We sought to evaluate the impact of the May 2012 Ontario, Canada, cervical cancer screening guideline change on Papanicolaou (Pap) and chlamydia trachomatis (chlamydia) testing and incidence. METHODS: We extracted population-based physician billing claims data to identify Pap and chlamydia tests and public health surveillance data to identify chlamydia cases...
July 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28694121/quasi-experimental-study-designs-series-paper-1-history-and-introduction
#11
Till Bärnighausen, John-Arne Røttingen, Peter Rockers, Ian Shemilt, Peter Tugwell
OBJECTIVE: To contrast the historical development of experiments and quasi-experiments and provide the motivation for a journal series on quasi-experimental designs in health research STUDY DESIGN: A short historical narrative, with concrete examples, and arguments based on an understanding of the practice of health research and evidence synthesis RESULTS: Health research has played a key role in developing today's gold standard for causal inference - the randomized controlled multiply blinded trial...
July 7, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28693347/improving-physician-communication-with-patients-as-measured-by-hcahps-using-a-standardized-communication-model
#12
Devin J Horton, Peter M Yarbrough, Nathan Wanner, Ryan D Murphy, Polina V Kukhareva, Kensaku Kawamoto
Physicians often fail to communicate well with patients. The objective of this retrospective controlled interrupted time series study was to evaluate the impact of a standardized communication intervention to improve physician communication. All patients ages 18 years or older (N = 7739 visits) admitted to University of Utah Health Care in Salt Lake City, Utah, from July 1, 2012, to June 31, 2014, were included. Obstetrics, rehabilitation, and psychiatric patients were excluded. The primary outcome was the percentage of patients who answered "Always" to all HCAHPS questions regarding physician-patient communication...
February 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28686555/heat-related-mortality-in-japan-after-the-2011-fukushima-disaster-an-analysis-of-potential-influence-of-reduced-electricity-consumption
#13
Yoonhee Kim, Antonio Gasparrini, Masahiro Hashizume, Yasushi Honda, Chris Fook Sheng Ng, Ben Armstrong
BACKGROUND: In March 2011, the Great East Japan Earthquake devastated several power stations and caused severe electricity shortages. This accident was followed by the implementation of policies to reduce summer electricity consumption in the affected areas, for example, by limiting air-conditioning (AC) use. This provided a natural experimental scenario to investigate if these policies were associated with an increase in heat-related mortality. OBJECTIVES: We examined whether the reduced electricity consumption in warm season modified heat-related mortality from 2008 to 2012...
July 6, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28685503/interventions-to-prevent-occupational-noise-induced-hearing-loss
#14
REVIEW
Christina Tikka, Jos H Verbeek, Erik Kateman, Thais C Morata, Wouter A Dreschler, Silvia Ferrite
BACKGROUND: This is the second update of a Cochrane Review originally published in 2009. Millions of workers worldwide are exposed to noise levels that increase their risk of hearing disorders. There is uncertainty about the effectiveness of hearing loss prevention interventions. OBJECTIVES: To assess the effectiveness of non-pharmaceutical interventions for preventing occupational noise exposure or occupational hearing loss compared to no intervention or alternative interventions...
July 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28685038/user-fee-removal-improves-equity-of-children-s-health-care-utilization-and-reduces-families-financial-burden-evidence-from-jamaica
#15
Zhihui Li, Mingqiang Li, Günther Fink, Paul Bourne, Till Bärnighausen, Rifat Atun
BACKGROUND: The impact of user-fee policies on the equity of health care utilization and households' financial burdens has remained largely unexplored in Latin American and the Caribbean, as well as in upper-middle-income countries. This paper assesses the short- and long-term impacts of Jamaica's user-fee-removal for children in 2007. METHODS: This study utilizes 14 rounds of data from the Jamaica Survey of Living Conditions (JSLC) for the periods 1996 to 2012...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28682689/regionalization-and-outcomes-of-lung-cancer-surgery-in-ontario-canada
#16
Anna M Bendzsak, Nancy N Baxter, Gail E Darling, Peter C Austin, David R Urbach
Purpose Regionalization of complex surgery to high-volume hospitals has been advocated based on cross-sectional volume-outcome studies. In April 2007, the agency overseeing cancer care in Ontario, Canada, implemented a policy to regionalize lung cancer surgery at 14 designated hospitals, enforced by economic incentives and penalties. We studied the effects of implementation of this policy. Methods Using administrative health data, we used interrupted time series models to analyze the immediate and delayed effects of implementation of the policy on the distribution of lung cancer surgery among hospitals, surgical outcomes, and health services use...
July 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28679491/effectiveness-of-adaptive-e-learning-environments-on-knowledge-competence-and-behavior-in-health-professionals-and-students-protocol-for-a-systematic-review-and-meta-analysis
#17
Guillaume Fontaine, Sylvie Cossette, Marc-André Maheu-Cadotte, Tanya Mailhot, Marie-France Deschênes, Gabrielle Mathieu-Dupuis
BACKGROUND: Adaptive e-learning environments (AEEs) can provide tailored instruction by adapting content, navigation, presentation, multimedia, and tools to each user's navigation behavior, individual objectives, knowledge, and preferences. AEEs can have various levels of complexity, ranging from systems using a simple adaptive functionality to systems using artificial intelligence. While AEEs are promising, their effectiveness for the education of health professionals and health professions students remains unclear...
July 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28674142/methods-applications-interpretations-and-challenges-of-interrupted-time-series-its-data-protocol-for-a-scoping-review
#18
Joycelyne E Ewusie, Erik Blondal, Charlene Soobiah, Joseph Beyene, Lehana Thabane, Sharon E Straus, Jemila S Hamid
OBJECTIVES: Interrupted time series (ITS) design involves collecting data across multiple time points before and after the implementation of an intervention to assess the effect of the intervention on an outcome. ITS designs have become increasingly common in recent times with frequent use in assessing impact of evidence implementation interventions. Several statistical methods are currently available for analysing data from ITS designs; however, there is a lack of guidance on which methods are optimal for different data types and on their implications in interpreting results...
July 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28670711/later-school-start-times-for-supporting-the-education-health-and-well-being-of-high-school-students
#19
REVIEW
Robert Marx, Emily E Tanner-Smith, Colleen M Davison, Lee-Anne Ufholz, John Freeman, Ravi Shankar, Lisa Newton, Robert S Brown, Alyssa S Parpia, Ioana Cozma, Shawn Hendrikx
BACKGROUND: A number of school systems worldwide have proposed and implemented later school start times as a means of avoiding the potentially negative impacts that early morning schedules can have on adolescent students. Even mild sleep deprivation has been associated with significant health and educational concerns: increased risk for accidents and injuries, impaired learning, aggression, memory loss, poor self-esteem, and changes in metabolism. Although researchers have begun to explore the effects of delayed school start time, no one has conducted a rigorous review of evidence to determine whether later school start times support adolescent health, education, and well-being...
July 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28665882/continuous-quality-improvement-intervention-for-adolescent-and-young-adult-hiv-testing-services-in-kenya-improves-hiv-knowledge
#20
Anjuli D Wagner, Cyrus Mugo, Shay Bluemer-Miroite, Peter M Mutiti, Dalton C Wamalwa, David Bukusi, Jillian Neary, Irene N Njuguna, Gabrielle O'Malley, Grace C John-Stewart, Jennifer A Slyker, Pamela K Kohler
OBJECTIVES: To determine whether continuous quality improvement (CQI) improves quality of HIV testing services for adolescents and young adults (AYA). DESIGN: CQI was introduced at two HIV testing settings: Youth Centre and Voluntary Counseling and Testing (VCT) Center, at a national referral hospital in Nairobi, Kenya. METHODS: Primary outcomes were AYA satisfaction with HIV testing services, intent to return, and accurate HIV prevention and transmission knowledge...
July 1, 2017: AIDS
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