keyword
MENU ▼
Read by QxMD icon Read
search

HS cTnI

keyword
https://www.readbyqxmd.com/read/29770799/heart-type-fatty-acid-binding-protein-h-fabp-as-a-biomarker-for-acute-myocardial-injury-and-long-term-post-ischemic-prognosis
#1
REVIEW
Xiao-Dong Ye, Yi He, Sheng Wang, Gordon T Wong, Michael G Irwin, Zhengyuan Xia
Acute myocardial infarction (AMI) is a life-threatening event. Even with timely treatment, acute ischemic myocardial injury and ensuing ischemia reperfusion injury (IRI) can still be difficult issues to tackle. Apart from radiological and other auxiliary examinations, laboratory tests of applicable cardiac biomarkers are also necessary for early diagnosis and close monitoring of this disorder. Heart-type fatty acid binding protein (H-FABP), which mainly exists inside cardiomyocytes, has recently emerged as a potentially promising biomarker for myocardial injury...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#2
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29750940/the-importance-of-low-level-qc-for-high-sensitivity-troponin-assays
#3
Peter E Hickman, Gus Koerbin, Tony Badrick, Carmen Oakman, Julia M Potter
BACKGROUND: With the advent of the new high-sensitivity troponin assays, it is becoming critical to measure troponin accurately to low concentrations. To ensure assay performance is acceptable, appropriate QC must be run. METHODS: In addition to the routine use of commercial QC material, we prepared pools of human QC material with low troponin concentrations close to the limit of quantitation, and ran these regularly on our laboratory analysers. RESULTS: Over 3 years we found no drift or shift in our hs-cTnI assay...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29750939/first-high-sensitivity-cardiac-troponin-i-assay-cleared-by-the-united-states-food-and-drug-administration-validation-and-implications
#4
Robert H Christenson, Kristin Mullins, Show-Hong Duh
BACKGROUND: High-Sensitivity (hs) cardiac troponin (cTn) assays are categorized by two criteria: (i) cTn values above the limit of detection (LoD) for >50% of male and female healthy cohorts of ≥300 individuals; (ii) imprecision ≤10% total %CV for sex-specific 99th-percentile clinical decision values (CDVs). No documented hs-Tn assay has yet been FDA-cleared. METHODS: The PATHFAST cTnI-II assay's LoD was 2.3 ng/L using CLSI EP-17. The AACC Universal Sample Bank of 847 healthy men (50...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29750937/the-potential-role-of-a-turbidimetric-heart-type-fatty-acid-binding-protein-assay-to-aid-in-the-interpretation-of-persistently-elevated-non-changing-cardiac-troponin-i-concentrations
#5
Peter A Kavsak, Craig Ainsworth, Donald M Arnold, Terry Scott, Lorna Clark, Josko Ivica, Katharine Mackett, Richard Whitlock, Andrew Worster
BACKGROUND: Elevated and non-changing high-sensitivity cardiac troponin (hs-cTn) concentrations may suggest a process other than acute injury, possibly due to chronic condition(s) causing the elevation, an analytical error/interference or the formation of macrocomplexes. Heart-type fatty acid binding protein (H-FABP) might be useful in this setting to identify the etiology of abnormally high and non-changing cTn concentrations which could aid clinical decision making in the hospital setting...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29746826/high-sensitivity-cardiac-troponin-i-and-risk-of-incident-atrial-fibrillation-hospitalisation-in-an-australian-community-based-cohort-the-busselton-health-study
#6
Kun Zhu, Joseph Hung, Mark Divitini, Kevin Murray, Ee Mun Lim, Andrew St John, John P Walsh, Matthew Knuiman
OBJECTIVE: The identification of individuals at risk of atrial fibrillation (AF) remains a challenge. We investigated whether high-sensitive cardiac troponin I (hs-cTnI) is an independent predictor of incident atrial fibrillation (AF) hospitalisation in an Australian community-based cohort. METHODS: Serum hs-cTnI was measured in 1641 men and 2189 women in the Busselton Health Study 1994/1995 Cohort aged 25-84 years at baseline. Data on incident AF hospitalisation over 20 years follow-up were obtained by data linkage...
May 7, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29691270/combining-high-sensitivity-cardiac-troponin-i-and-cardiac-troponin-t-in-the-early-diagnosis-of-acute-myocardial-infarction
#7
Noreen van der Linden, Karin Wildi, Raphael Twerenbold, John W Pickering, Martin Than, Louise Cullen, Jaimi Greenslade, William Parsonage, Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Maria Rubini Giménez, Lieke J J Klinkenberg, Otto Bekers, Aline Schöni, Dagmar I Keller, Zaid Sabti, Christian Puelacher, Janosch Cupa, Lukas Schumacher, Nikola Kozhuharov, Karin Grimm, Samyut Shrestha, Dayana Flores, Michael Freese, Claudia Stelzig, Ivo Strebel, Òscar Miró, Katharina Rentsch, Beata Morawiec, Damian Kawecki, Wanda Kloos, Jens Lohrmann, A Mark Richards, Richard Troughton, Christopher Pemberton, Stefan Osswald, Marja P van Dieijen-Visser, Alma M Mingels, Tobias Reichlin, Steven J R Meex, Christian Mueller
Background -Combining two signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction (AMI) with a single blood draw. We aimed to evaluate the diagnostic performance of combinations of high sensitivity (hs) cTnI and hs-cTnT for the early diagnosis of AMI. Methods -The diagnostic performance of combining hs-cTnI (Architect, Abbott) and hs-cTnT (Elecsys, Roche) concentrations (sum, product, ratio and a combination algorithm) obtained at the time of presentation was evaluated in a large multicenter diagnostic study of patients with suspected AMI...
April 24, 2018: Circulation
https://www.readbyqxmd.com/read/29672821/a-rapid-differential-effect-of-rosuvastatin-and-atorvastatin-on-high-sensitivity-cardiac-troponin-i-in-subjects-with-stable-cardiovascular-disease
#8
Mathijs C Bodde, Paul Welsh, Sandrin C Bergheanu, Willem M Lijfering, Bart Mertens, An-Ho Liem, Arnoud van der Laarse, Naveed Sattar, J Wouter Jukema
Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high-sensitivity troponin -I (hs-cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized, to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up-titrated in 6 week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs-cTnI concentrations were measured at baseline and at 6 and 18 weeks of follow-up...
April 19, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29607894/high-cardiac-troponin-i-is-associated-with-transesophageal-echocardiographic-risk-of-thromboembolism-and-ischemic-stroke-events-in-non-valvular-atrial-fibrillation-patients
#9
Shuhei Tanaka, Tadakazu Hirai, Kyoko Inao, Nobuyuki Fukuda, Keiko Nakagawa, Hiroshi Inoue, Koichiro Kinugawa
BACKGROUND: Abnormalities in the left atrium (LA) detected on transesophageal echocardiography (TEE) are reliable predictors of thromboembolism in patients with atrial fibrillation (AF). Cardiac troponin I, a marker of subclinical myocardial damage, may also be a predictor of thromboembolic events in patients with AF. The relationship between cardiac troponin I and thromboembolic risk on TEE, however, remains unclear.Methods and Results:TEE and laboratory data, including high sensitivity cardiac troponin I (hs-cTnI) and CHA2 DS2 -VASc score, were analyzed in 199 patients with non-valvular AF (NVAF)...
March 31, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29554376/high-sensitivity-cardiac-troponin-i-is-a-biomarker-for-occult-coronary-plaque-burden-and-cardiovascular-events-in-patients-with-rheumatoid-arthritis
#10
George A Karpouzas, Joel Estis, Panteha Rezaeian, John Todd, Matthew J Budoff
Objectives: Patients with RA display greater occult coronary atherosclerosis burden and experience higher cardiovascular morbidity and mortality compared with controls. We here explored whether pro-inflammatory cytokines and high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, correlated with plaque burden and cardiovascular events (CVEs) in RA. Methods: We evaluated 150 patients with 64-slice coronary CT angiography. Coronary artery calcium, number of segments with plaque (segment involvement score), stenotic severity and plaque burden were assessed...
March 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29533903/assessing-matrix-interferences-and-comparability-between-the-abbott-diagnostics-and-the-beckman-coulter-high-sensitivity-cardiac-troponin-i-assays
#11
Peter A Kavsak, Paul Malinowski, Chantele Roy, Lorna Clark, Shana Lamers
BACKGROUND: Analytical evaluation of high-sensitivity cardiac troponin (hs-cTn) assays, with particular attention to imprecision, interferences and matrix effects, at normal cTn concentrations, is of utmost importance as many different clinical algorithms use concentration cutoffs <10 ng/L for decision-making. The objective for the present analytical study was to compare the new Beckman Coulter hs-cTnI assay (Access hsTnI) to Abbott's hs-cTnI assay in different matrices and for different interferences, with a focus on concentrations <10 ng/L...
March 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29477263/high-sensitivity-cardiac-troponin-t-is-superior-to-troponin-i-in-the-prediction-of-mortality-in-patients-without-acute-coronary-syndrome
#12
Ásthildur Árnadóttir, Kirstine Roll Vestergaard, Jannik Pallisgaard, György Sölétormos, Rolf Steffensen, Jens P Goetze, Kasper Iversen
BACKGROUND: Differences in prevalence and prognostic information of cardiac troponin T (cTnT) and I (cTnI) concentrations in patients without acute coronary syndrome (ACS) are insufficiently investigated. High-sensitivity assays (hs-cTn) have led to an increased interest in hs-cTn for risk stratification. Here, we compare hs-cTnT and hs-cTnI in prediction of mortality patients without ACS. METHOD AND RESULTS: Patients aged >18 years, consecutively admitted to an emergency department (ED) were included...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29421020/effects-of-hyperoxia-on-myocardial-injury-following-cardioversion-a-randomized-clinical-trial
#13
Kasper Glerup Lauridsen, Anders Sjørslev Schmidt, Kasper Adelborg, Leif Bach, Nete Hornung, Simon Munkesø Jepsen, Charles D Deakin, Hans Rickers, Bo Løfgren
Oxygen has long been assumed beneficial for all ill and injured patients. However, hyperoxia may be harmful and aggravate myocardial injury such as that caused by myocardial infarction. We aimed to investigate if hyperoxia increases myocardial injury following direct current cardioversion compared with room air. METHODS: Patients undergoing elective biphasic cardioversion for atrial fibrillation or atrial flutter were randomized to receive room air or oxygen (10-15 L/min) during the procedure...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29419380/evaluating-rapid-rule-out-of-acute-myocardial-infarction-using-a-high-sensitivity-cardiac-troponin-i-assay-at-presentation
#14
Jaimi Greenslade, Elizabeth Cho, Christopher Van Hise, Tracey Hawkins, William Parsonage, Jacobus Ungerer, Jillian Tate, Carel Pretorius, Martin Than, Louise Cullen
BACKGROUND: Low concentrations of cardiac troponin (cTn) have been recommended for rapid rule-out of acute myocardial infarction (AMI). We examined the Beckman Coulter Access high-sensitivity cardiac troponin I (hs-cTnI) assay to identify a single test threshold that can safely rule out AMI. METHODS: This analysis used stored samples collected in 2 prospective observational studies. In all, 1871 patients presenting to a tertiary emergency department with symptoms of acute coronary syndrome had blood taken for measurement of cTnI on presentation...
May 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29401554/prognostic-role-of-high-sensitivity-cardiac-troponin-i-and-soluble-suppression-of-tumorigenicity-2-in-surgical-intensive-care-unit-patients-undergoing-non-cardiac-surgery
#15
Hyun Suk Yang, Mina Hur, Ahram Yi, Hanah Kim, Jayoun Kim
BACKGROUND: The prognostic utility of cardiac biomarkers, high-sensitivity cardiac troponin I (hs-cTnI) and soluble suppression of tumorigenicity-2 (sST2), in non-cardiac surgery is not well-defined. We evaluated hs-cTnI and sST2 as predictors of 30-day major adverse cardiac events (MACE) in patients admitted to the surgical intensive care unit (SICU) following major non-cardiac surgery. METHODS: hs-cTnI and sST2 concentrations were measured in 175 SICU patients immediately following surgery and for three days postoperatively...
May 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29398998/postoperative-myocardial-injury-and-inflammation-is-not-blunted-by-a-trial-of-atorvastatin-in-orthopedic-surgery-patients
#16
Anne R Bass, Jackie D Szymonifka, Matthew T Rondina, Margaret Bogardus, Mitchell G Scott, Scott C Woller, Scott M Stevens, Charles Eby, Kerri Merritt, Alejandro Gonzalez Della Valle, Gerard Moskowitz, Eva Flores, Brian F Gage
Background: Orthopedic patients are at risk for adverse postoperative cardiovascular outcomes. Questions/Purposes: This pilot randomized controlled trial (RCT) of atorvastatin vs. placebo in orthopedic surgery patients was performed in order to assess: (1) the prevalence of perioperative myocardial injury; (2) the effect of atorvastatin on perioperative inflammation; and (3) the feasibility of performing a large RCT of statin therapy in orthopedic patients. Methods: Hip fracture (hip Fx) and total hip and knee replacement (THR and TKR) patients were randomized 1:1 to atorvastatin 40 mg daily vs...
February 2018: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/29378734/myocardial-injury-in-patients-with-sepsis-and-its-association-with-long-term-outcome
#17
Jos F Frencken, Dirk W Donker, Cristian Spitoni, Marlies E Koster-Brouwer, Ivo W Soliman, David S Y Ong, Janneke Horn, Tom van der Poll, Wilton A van Klei, Marc J M Bonten, Olaf L Cremer
BACKGROUND: Sepsis is frequently complicated by the release of cardiac troponin, but the clinical significance of this myocardial injury remains unclear. We studied the associations between troponin release during sepsis and 1-year outcomes. METHODS AND RESULTS: We enrolled consecutive patients with sepsis in 2 Dutch intensive care units between 2011 and 2013. Subjects with a clinically apparent cause of troponin release were excluded. High-sensitivity cardiac troponin I (hs-cTnI) concentration in plasma was measured daily during the first 4 intensive care unit days, and multivariable Cox regression analysis was used to model its association with 1-year mortality while adjusting for confounding...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29366992/differential-effects-of-brachial-and-central-blood-pressures-on-circulating-levels-of-high-sensitivity-cardiac-troponin-i-in-the-general-population
#18
Tomonori Sugiura, Yasuaki Dohi, Hiroyuki Takase, Atsushi Ito, Satoshi Fujii, Nobuyuki Ohte
BACKGROUND AND AIMS: Severe cardiac load increases circulating concentrations of high-sensitivity cardiac troponin I (hs-cTnI) through non-ischemic mechanisms. The present study was designed to investigate the effect of central blood pressure (BP), which reflects cardiac load rather than peripheral BP, on serum concentrations of hs-cTnI in subjects with or without increased arterial stiffness. METHODS: We enrolled 1210 participants taking part in a yearly health checkup program...
February 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29366835/performance-of-high-sensitivity-cardiac-troponin-in-the-emergency-department-for-myocardial-infarction-and-a-composite-cardiac-outcome-across-different-estimated-glomerular-filtration-rates
#19
Peter A Kavsak, Andrew Worster, Colleen Shortt, Jinhui Ma, Natasha Clayton, Jonathan Sherbino, Stephen A Hill, Matthew McQueen, Lauren E Griffith, Shamir R Mehta, Andrew D McRae, P J Devereaux
BACKGROUND: Clinicians regularly observe increased high-sensitivity cardiac troponin (hs-cTn) concentrations in patients with low estimated glomerular filtration rate (eGFR). The challenge is to differentiate acute coronary syndrome (ACS) from increased hs-cTn results across a range of eGFR. The objective of this study was to determined the optimal hs-cTn concentrations for acute myocardial infarction (MI) and a composite cardiovascular outcome across different eGFR ranges and to assess the utility of a low hs-cTn cutoff to rule-out events...
April 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29366834/the-cardiac-troponin-response-following-physical-exercise-in-relation-to-biomarker-criteria-for-acute-myocardial-infarction-the-north-sea-race-endurance-exercise-study-needed-2013
#20
Øyvind Skadberg, Øyunn Kleiven, Stein Ørn, Magnus F Bjørkavoll-Bergseth, Tor H Melberg, Torbjørn Omland, Kristin M Aakre
BACKGROUND: The aim of this study was to investigate troponin (cTn) dynamics for both genders, compared the different release patterns to the gender specific 99th percentile and to current biomarker criteria for diagnosing myocardial infarction (MI). METHODS: Serum was collected from 97 recreational cyclists 24 h before and immediately, 3 and 24 h following a 91-km bike race. hs-cTnI (Abbott) and hs-cTnT (Roche) were measured. Conventional or CT coronary angiography was performed in the 13 participants with the highest hs-cTnI (>140 ng/L)...
April 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
keyword
keyword
88639
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"