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https://www.readbyqxmd.com/read/29331272/high-sensitivity-cardiac-troponin-and-new-onset-heart-failure-a-systematic-review-and-meta-analysis-of-67-063-patients-with-4-165-incident-heart-failure-events
#1
Jonathan D W Evans, Stephen J H Dobbin, Stephen J Pettit, Emanuele Di Angelantonio, Peter Willeit
OBJECTIVES: The aim of this study was to systematically collate and appraise the available evidence regarding the association between high-sensitivity cardiac troponin (hs-cTn) and incident heart failure (HF) and the added value of hs-cTn in HF prediction. BACKGROUND: Identification of subjects at high risk for HF and early risk factor modification with medications such as angiotensin-converting enzyme inhibitors may delay the onset of HF. Hs-cTn has been suggested as a prognostic marker for the incidence of first-ever HF in asymptomatic subjects...
January 3, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29303766/no-additional-value-of-conventional-and-high-sensitivity-cardiac-troponin-over-clinical-scoring-systems-in-the-differential-diagnosis-of-type-1-versus-type-2-myocardial-infarction
#2
Luciano Consuegra-Sánchez, Juan José Martínez-Díaz, Luis García de Guadiana-Romualdo, Samantha Wasniewski, Patricia Esteban-Torrella, Francisco Guillermo Clavel-Ruipérez, Alfredo Bardají, Juan Antonio Castillo-Moreno, Juan Carlos Kaski
BACKGROUND: The distinction of type 1 and type 2 myocardial infarction (MI) is of major clinical importance. Our aim was to evaluate the diagnostic ability of absolute and relative conventional cardiac troponin I (cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the distinction between type 1 and type 2 MI in patients presenting at the emergency department with non-ST-segment elevation acute chest pain within the first 12 h. METHODS: We measured cTnI (Dimension Vista) and hs-cTnT (Cobas e601) concentrations at presentation and after 4 h in 200 patients presenting with suspected acute MI...
January 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29298237/elevated-high-sensitivity-troponin-i-during-living-donor-liver-transplantation-is-associated-with-postoperative-adverse-outcomes
#3
Jungchan Park, Seung Hwa Lee, Sangbin Han, Ki Yoon Kim, Go Eun Kim, Myungsoo Park, Suk-Koo Lee, Gyu-Seong Choi, Soohyun Ahn, Hyeon Seon Ahn, Gaab Soo Kim
BACKGROUND: This study aimed to evaluate risk factors and postoperative clinical outcome associated with myocardial injury detected by an elevated high-sensitivity cardiac troponin I (hs-cTnI) immediately after living donor liver transplantation (LDLT). METHODS: Between January 2011 and December 2016, 313 adult recipients undergoing LDLT, with normal preoperative hs-cTnI were selected. Hs-cTnI level above 0.04 ng/mL according to 99th percentile reference limit was defined as myocardial injury...
January 2, 2018: Transplantation
https://www.readbyqxmd.com/read/29285227/effects-of-trimetazidine-on-periprocedural-microrna-21-expression-by-cd4-t-lymphocytes-in-patients-with-unstable-angina-pectoris
#4
Qiang Su, Lang Li, Jinmin Zhao, Yuhan Sun, Huafeng Yang
Objective: Post-percutaneous coronary intervention (PCI) myocardial injury is related to the CD4+ T lymphocyte-mediated inflammatory response. microRNA-21 expression is associated with CD4+ T lymphocyte activation. The pre-PCI use of trimetazidine prevents periprocedural myocardial injury and reduces inflammatory cytokine levels. This study aimed to assess the effects of trimetazidine on periprocedural microRNA-21 expression by CD4+ T lymphocytes in patients with unstable angina pectoris...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29246240/myocardial-inflammation-injury-and-infarction-during-on-pump-coronary-artery-bypass-graft-surgery
#5
Shirjel R Alam, Colin Stirrat, Nick Spath, Vipin Zamvar, Renzo Pessotto, Marc R Dweck, Colin Moore, Scott Semple, Ahmed El-Medany, Divya Manoharan, Nicholas L Mills, Anoop Shah, Saeed Mirsadraee, David E Newby, Peter A Henriksen
BACKGROUND: Myocardial inflammation and injury occur during coronary artery bypass graft (CABG) surgery. We aimed to characterise these processes during routine CABG surgery to inform the diagnosis of type 5 myocardial infarction. METHODS: We assessed 87 patients with stable coronary artery disease who underwent elective CABG surgery. Myocardial inflammation, injury and infarction were assessed using plasma inflammatory biomarkers, high-sensitivity cardiac troponin I (hs-cTnI) and cardiac magnetic resonance imaging (CMR) using both late gadolinium enhancement (LGE) and ultrasmall superparamagnetic particles of iron oxide (USPIO)...
December 16, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29232768/modification-of-the-thrombolysis-in-myocardial-infarction-risk-score-for-patients-presenting-with-chest-pain-to-the-emergency-department
#6
Jaimi H Greenslade, Kimberly Chung, William A Parsonage, Tracey Hawkins, Martin Than, John W Pickering, Louise Cullen
OBJECTIVE: To develop a modified Thrombolysis in Myocardial Infarction (TIMI) score to effectively risk stratify patients presenting to the ED with chest pain. METHODS: A prospective observational study was conducted at two metropolitan EDs. Data were obtained during patient interview. The primary outcome was major adverse cardiovascular events (MACE) within 30 days of presentation. Two separate modifications of the TIMI score were developed. These scores were compared to the original TIMI in terms of the area under the receiver operating characteristic curve and diagnostic accuracy statistics (sensitivity, specificity, positive and negative predictive values)...
December 12, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29226754/cardiac-troponins-25-years-on-the-stage-and-still-improving-their-clinical-value
#7
Aitor Alquézar-Arbé, Alessandro Sionis, Jorge Ordoñez-Llanos
Twenty-five years ago, non-isotopic immunoassays for measuring the cardiac specific isoforms of troponin I (cTnI) and T (cTnT) were developed. Both biomarkers radically changed the diagnosis, prognosis, and therapy indication of acute coronary syndromes (ACS) and, particularly, of myocardial infarction (MI). However, cardiac troponins (cTn) rapidly demonstrated their usefulness in other cardiac and non-cardiac conditions, a part of the ischemic coronary diseases. Consequently, the number of patients to be tested for cTn and the number of tests requested to clinical laboratories sharply increased...
December 11, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29170106/one-year-in-vitro-stability-of-cardiac-troponins-and-galectin-3-in-different-sample-types
#8
Margot Egger, Benjamin Dieplinger, Thomas Mueller
BACKGROUND: We assessed the long-term in vitro stability of cardiac troponins and galectin-3 under different storage conditions. METHODS: We used high-sensitivity cardiac troponin I (hs-cTnI) and galectin-3 assays from Abbott and a high-sensitivity cardiac troponin T (hs-cTnT) assay from Roche. The analyte concentrations of 30 patients were measured in heparin-treated plasma, EDTA-treated plasma and serum samples after the following storage conditions: 1) samples used immediately after blood collection for baseline measurements; 2) samples stored for 0...
November 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29169757/hs-ctroponins-for-the-prediction-of-recurrent-cardiovascular-events-in-patients-with-established-chd-a-comparative-analysis-from-the-karola-study
#9
Henning Jansen, Andrea Jänsch, Lutz P Breitling, Liesa Hoppe, Dhayana Dallmeier, Roman Schmucker, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
BACKGROUND: High-sensitivity Troponins (hs-cTnT and hs-cTnI) are established biomarkers to identify patients with an acute myocardial infarction. However, data comparing the capacity of these two subtypes in predicting recurrent cardiovascular disease (CVD) events in a population with stable coronary heart disease (CHD) after adjustment for several other modern biomarkers are lacking. METHODS: We measured both troponins at baseline in 1068 CHD patients, followed them for 13years, assessed a combined CVD endpoint, and adjusted for multiple traditional and novel risk factors...
January 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29169258/high-sensitivity-cardiac-troponin-concentrations-at-emergency-department-presentation-in-females-and-males-with-an-acute-cardiac-outcome
#10
Peter A Kavsak, Andrew Worster, Colleen Shortt, Jinhui Ma, Natasha Clayton, Jonathan Sherbino, Stephen A Hill, Matthew McQueen, Lauren Griffith, Shamir R Mehta, P J Devereaux
Background There is interest in utilizing different cut-offs per sex for high-sensitivity cardiac troponin I (hs-cTnI) but less so for high-sensitivity cardiac troponin T (hs-cTnT) for patient management in the acute setting. Our objective was to assess if differences in hs-cTn concentrations exist between males and females for an acute cardiac outcome following the presentation measurement in the emergency department. Methods An observational emergency department population with hs-cTn measurements (Roche Diagnostics and Abbott Diagnostics) at presentation with seven-day outcomes for a composite acute cardiac outcome (i...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29145895/comparative-analysis-of-high-sensitivity-cardiac-troponin-i-and-t-for-their-association-with-coronary-computed-tomography-assessed-calcium-scoring-represented-by-the-agatston-score
#11
Jonas Rusnak, Michael Behnes, Thomas Henzler, Nadine Reckord, Nils Vogler, Mathias Meyer, Ursula Hoffmann, Michele Natale, Julia Hoffmann, Sonja Hamed, Kathrin Weidner, Siegfried Lang, Agnibh Mukherji, Holger Haubenreisser, Stefan O Schoenberg, Martin Borggrefe, Thomas Bertsch, Ibrahim Akin
BACKGROUND: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). METHODS: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD...
November 16, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29131477/a-risk-assessment-score-and-initial-high-sensitivity-troponin-combine-to-identify-low-risk-of-acute-myocardial-infarction-in-the-emergency-department
#12
John W Pickering, Dylan Flaws, Stephen W Smith, Jaimi Greenslade, Louise Cullen, William Parsonage, Edward Carlton, A Mark Richards, Richard Troughton, Christopher Pemberton, Peter M George, Martin P Than
OBJECTIVES: Early discharge of patients with presentations triggering assessment for possible acute coronary syndrome is safe when clinical assessment indicates low-risk, biomarkers are negative, and electrocardiograms (ECGs) are non-ischemic. We hypothesized that the Emergency Department Assessment of Chest Pain Score (EDACS) combined with a single measurement of high-sensitivity cardiac troponin (hs-cTn) could allow early discharge of a clinically meaningful proportion of patients. METHODS: We pooled data from 4 patient cohorts from New Zealand and Australia presenting to an ED with symptoms suggestive of ACS...
November 13, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29131250/effects-of-remote-ischemic-preconditioning-on-myocardial-injury-and-endothelial-function-and-prognosis-after-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndrome
#13
F-Z Zhou, W Song, L-H Yin, Z-F Song, S Yang, F-B Yang, J-F Liu, Y-G Song, H-Y Zhang, Z-M Zhang
OBJECTIVE: To explore the effects of remote ischemic preconditioning on myocardial injury and prognosis after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome. PATIENTS AND METHODS: The study was a single center, prospective, randomized, controlled study. A total of 184 patients with unstable angina undergoing elective PCI were randomly assigned to remote ischemic preconditioning group (induced by four times of 5-min inflations of a blood pressure cuff to 200 mmHg around the upper arm, followed by 5-min intervals of reperfusion at 1 h before PCI therapy) or control group (an uninflated cuff around the arm)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29121498/cardiac-involvement-in-myotonic-dystrophy-the-role-of-troponins-and-n-terminal-pro-b-type-natriuretic-peptide
#14
Rea Valaperta, Claudia De Siena, Rosanna Cardani, Fortunata Lombardia, Edina Cenko, Benedetta Rampoldi, Barbara Fossati, Elisa Brigonzi, Roberta Rigolini, Paola Gaia, Giovanni Meola, Elena Costa, Raffaele Bugiardini
BACKGROUND AND AIMS: Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are dominant inherited muscular dystrophies with multiple systemic involvement, often producing cardiac injury. This study sought to determine the clinical significance of elevated high sensitivity cardiac troponin T and I (hs-cTnT and hs-cTnI), and N-terminal pro B-type natriuretic peptide (NT-pro-BNP) in this population. METHODS: Sixty DM patients (35 men and 25 women; mean age: 45.1 years, range: 12-73 years) underwent clinical cardiac investigations and measurements of serum hs-cTnT, hs-cTnI, creatine kinase (CK), and NT-proBNP...
October 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29107010/combining-high-sensitivity-cardiac-troponin-and-b-type-natriuretic-peptide-in-the-detection-of-inducible-myocardial-ischemia
#15
Christian Puelacher, Max Wagener, Ursina Honegger, Mustafa Assadian, Nicolas Schaerli, Deborah Mueller, Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Karin Wildi, Zaid Sabti, Lorraine Sazgary, Patrick Badertscher, Jeanne du Fay de Lavallaz, Stella Marbot, Christoph Kaiser, Damian Wild, Michael J Zellweger, Tobias Reichlin, Christian Mueller
BACKGROUND: Single biomarker approaches provide only moderate accuracy in the non-invasive detection of exercise-induced myocardial ischemia. We therefore assessed the combination of the two most promising single biomarkers: high-sensitivity cardiac troponin I (hs-cTnI) and B-type natriuretic peptide (BNP). METHODS: Consecutive patients with suspected myocardial ischemia referred to stress myocardial perfusion single-photon emission tomography imaging (MPI) were enrolled...
November 8, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29101287/0-1-hour-triage-algorithm-for-myocardial-infarction-in-patients-with-renal-dysfunction
#16
Raphael Twerenbold, Patrick Badertscher, Jasper Boeddinghaus, Thomas Nestelberger, Karin Wildi, Christian Puelacher, Zaid Sabti, Maria Rubini Gimenez, Sandra Tschirky, Jeanne du Fay de Lavallaz, Nikola Kozhuharov, Lorraine Sazgary, Deborah Mueller, Tobias Breidthardt, Ivo Strebel, Dayana Flores Widmer, Samyut Shrestha, Òscar Miró, F Javier Martín-Sánchez, Beata Morawiec, Jiri Parenica, Nicolas Geigy, Dagmar I Keller, Katharina Rentsch, Arnold von Eckardstein, Stefan Osswald, Tobias Reichlin, Christian Mueller
Background -The European Society of Cardiology (ESC) recommends a 0/1h-algorithm for rapid rule-out and rule-in of Non-ST-Segment-Elevation Myocardial Infarction (NSTEMI) using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective of renal function. As patients with renal dysfunction (RD) frequently present with increased hs-cTn concentrations even in absence of NSTEMI, concern has been raised regarding the performance of the 0/1h-algorithm in RD. Methods -In a prospective multicenter diagnostic study enrolling unselected patients presenting with suspected NSTEMI to the emergency department, we assessed the diagnostic performance of the ESC 0/1h-algorithm using hs-cTnT and hs-cTnI in patients with RD, defined as an estimated glomerular filtration rate below 60mL/min/1...
November 3, 2017: Circulation
https://www.readbyqxmd.com/read/29095967/effects-of-defibrillation-shock-in-patients-implanted-with-a-subcutaneous-defibrillator-a-biomarker-study
#17
Antonio D'Onofrio, Vincenzo Russo, Valter Bianchi, Ciro Cavallaro, Silvia Leonardi, Stefano De Vivo, Filippo Vecchione, Anna Rago, Ernesto Ammendola, Vincenzo Tavoletta, Luigi Atripaldi, Paola Elvira Mocavero, Gerardo Nigro
Aims: Implantable cardioverter defibrillator (ICD) shocks are associated with a subsequent increased risk of death, and an elevation of cardiac enzymes has been measured after defibrillation testing (DFT). In an experimental swine study, subcutaneous ICD (S-ICD) shocks caused less myocardial damage than traditional ICD shocks. The aim of our study was to investigate the association between S-ICD shock and acute cardiac damage in humans, as evaluated by means of sensitive and highly specific circulating biomarkers...
October 31, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29079658/renal-dysfunction-influences-the-diagnostic-and-prognostic-performance-of-high-sensitivity-cardiac-troponin-i
#18
Ian Gunsolus, Yader Sandoval, Stephen W Smith, Anne Sexter, Karen Schulz, Charles A Herzog, Fred S Apple
Measures of cardiac troponin (cTn) may have lower specificity for myocardial infarction in patients with CKD. We examined the diagnostic accuracy of baseline and serial high-sensitivity cTnI (hs-cTnI) measurements for myocardial infarction and 30- and 180-day mortality according to renal function. hs-cTnI was measured (Abbott assay) using sex-specific 99th percentiles (women, 16 ng/L; men, 34 ng/L) in 1555 adults presenting to the emergency department with symptoms suggesting ischemia (NCT02060760). Myocardial infarction was adjudicated along universal definition classification...
October 27, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29079359/the-copeptin-response-after-physical-activity-is-not-associated-with-cardiac-biomarkers-or-asymptomatic-coronary-artery-disease
#19
Kristin M Aakre, Øyunn Kleiven, Øyvind Skadberg, Magnus F Bjørkavoll-Bergseth, Tor Melberg, Heidi Strand, Tor-Arne Hagve, Stein Ørn
BACKGROUND: Copeptin concentrations increase both during acute coronary syndrome and following physical exercise. The relationship between copeptin increase following physical exercise and coronary artery disease (CAD) is uncertain. The aim of this study was to 1) describe the copeptin response following strenuous physical exercise, and 2) investigate the determinants of exercise induced copeptin concentrations, particularly in relation to cardiac biomarkers and CAD. METHODS: Serum samples were collected from 97 recreational cyclists 24h before, and immediately, 3 and 24h after a 91-km bike race...
October 25, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29066610/high-sensitivity-cardiac-troponin-i-and-risk-of-cardiovascular-disease-in-an-australian-population-based-cohort
#20
Kun Zhu, Matthew Knuiman, Mark Divitini, Kevin Murray, Ee Mun Lim, Andrew St John, John P Walsh, Joseph Hung
OBJECTIVE: High-sensitivity cardiac troponin I (hs-cTnI) is an emerging biomarker for cardiovascular risk. We examined hs-cTnI as a predictor of mortality and cardiovascular outcomes in an Australian population-based cohort and evaluated if a sex difference exists. METHODS: Serum hs-cTnI was measured in the Busselton Health Study 1994/1995 Cohort (n=3939). Outcome measures were total and cardiovascular mortality, cardiovascular disease (CVD) and coronary heart disease (CHD) events, heart failure and stroke...
October 24, 2017: Heart: Official Journal of the British Cardiac Society
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