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Inflammatory factors

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https://www.readbyqxmd.com/read/28938560/inflammatory-factor-tnf-%C3%AE-promotes-the-growth-of-breast-cancer-via-the-positive-feedback-loop-of-tnfr1-nf-%C3%AE%C2%BAb-and-or-p38-p-stat3-hbxip-tnfr1
#1
Xiaoli Cai, Can Cao, Jiong Li, Fuquan Chen, Shuqin Zhang, Bowen Liu, Weiying Zhang, Xiaodong Zhang, Lihong Ye
In the connection between inflammation and cancer development, tumor necrosis factor-alpha (TNF-α) contributes to the tumorigenesis. However, the underlying mechanism remains poorly understood. In this study, we report that TNF-α enhances the growth of breast cancer through up-regulation of oncoprotein hepatitis B X-interacting protein (HBXIP). Our data showed that the levels of TNF-α were positively related to those of HBXIP in clinical breast cancer tissues. Moreover, TNF-α could up-regulate HBXIP in breast cancer cells...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938340/paediatric-traumatic-brain-injury-prognostic-insights-and-outlooks
#2
Alicia K Au, Robert S B Clark
PURPOSE OF REVIEW: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Prognostication of outcome following TBI is challenging in this population and likely requires complex, multimodal models to achieve clinically relevant accuracy. This review highlights injury characteristics, physiological indicators, biomarkers and neuromonitoring modalities predictive of outcome that may be integrated for future development of sensitive and specific prognostic models...
September 21, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28938336/arterial-stiffness-induced-by-carotid-calcification-leads-to-cerebral-gliosis-mediated-by-oxidative-stress
#3
Nataliya Sadekova, M Florencia Iulita, Diane Vallerand, Gervais Muhire, Mohamed Bourmoum, Audrey Claing, Hélène Girouard
BACKGROUND: Arterial stiffness is a risk factor for cognitive decline and dementia. However, its precise effects on the brain remain unexplored. Using a mouse model of carotid stiffness, we investigated its effect on glial activation and oxidative stress. METHODS: Arterial stiffness was induced by the application of calcium chloride to the adventitial region of the right carotid. Superoxide anion production, NADPH activity and levels, as well as glial activation were examined with immunohistochemical and biochemical approaches, 2-week postcalcification...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28938326/progress-on-botulinum-toxin-type-a-induced-pain-relief-in-the-field-of-plastics
#4
Xiaona Lu, Guocheng Chen, Pengjie Ren, Yan Yang, Fei Fan
OBJECTIVE: To retrospectively evaluate the effectiveness of Botulinum Toxin Type A (BTX-A) injections relieve pain in the field of plastic surgery and postoperative rehabilitation, and discuss the analgesic mechanism of BTX- A in plastics and related research progress. METHODS: From appearance to September 1, 2016, PUBMED, EMBASE, and Web of Science were searched, using the key words related to "Botulinum Toxin Type A" and "Pain." Furtherly, nonplastic surgery-related literature was excluded by manual screening...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938189/the-potent-suppressive-effect-of-%C3%AE-d-mannuronic-acid-m2000-on-molecular-expression-of-the-tlr-nf-kb-signaling-pathway-in-ankylosing-spondylitis-patients
#5
Maryam Roozbehkia, Mahdi Mahmoudi, Somaye Aletaha, Nima Rezaei, Mohammad Javad Fattahi, Fahimeh Jafarnezhad-Ansariha, Anis Barati, Abbas Mirshafiey
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by the inflammation of sacroiliac joints and axial skeleton. A combination of genetic, environmental and immunological factors are involved in AS's pathogenesis. TLRs are type I transmembrane glycoproteins that play a crucial role in the innate immune responses against invading pathogens. Observational studies have demonstrated a possible association between TLR dysregulation and AS. The β-d-mannuronic acid (M2000), as a novel NSAID with immunosuppressive property, has shown an inhibitory effect on Toll-like receptor (TLR) 2, 4 signaling in HEK293 cells...
September 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28938136/systemic-inflammatory-response-syndrome-in-the-course-of-status-epilepticus-7-year-two-center-observational-study
#6
Sebastian Szklener, Agnieszka Korchut, Magdalena Godek, Luiza Balicka-Adamik, Dariusz Bielecki, Robert Rejdak, Konrad Rejdak
OBJECTIVES: This study was aimed at identifying patients with systemic inflammatory response syndrome (SIRS) and determining whether the presence of SIRS on admission was associated with drug resistance and poor outcome in status epilepticus (SE) patients. METHODS: We conducted a prospective review of patients consecutively admitted to two territory centers over a 7-year period. SIRS was considered present if the necessary criteria persisted for 12h. Other potential outcome predictors in a cohort of patients with SE were also collected...
September 14, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28938131/characterization-of-the-changes-in-eicosanoid-profiles-of-activated-macrophages-treated-with-20-s-ginsenoside-rg3
#7
Jae Won Lee, Yu Ri Choi, Hyuck Jun Mok, Hyun-A Seong, Dae Young Lee, Geum-Soog Kim, Ji Hye Yoon, Kwang Pyo Kim, Hyung Don Kim
In this study, we used ultra-performance liquid chromatography coupled with tandem mass spectrometry to assess the levels of eicosanoids from RAW264.7 macrophages treated with lipopolysaccharides (LPS) and 20(S)-ginsenoside Rg3 (Rg3). The production of nitric oxide (NO) and the secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were increased in inflammatory macrophages treated with LPS. Rg3 treatment, however, decreased the levels of NO, TNF-α, and IL-6 in activated macrophages. Eicosanoids, known as major metabolites correlated with inflammation, have pro- or anti-inflammatory activities...
September 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28938125/selective-immuno-modulatory-effect-of-prolactin-upon-pro-inflammatory-response-in-human-fetal-membranes
#8
Pilar Flores-Espinosa, Eduardo Preciado-Martínez, Araceli Mejía-Salvador, Gabriela Sedano-González, Luisa Bermejo-Martínez, Adalberto Parra-Covarruvias, Guadalupe Estrada-Gutiérrez, Rodrigo Vega-Sánchez, Isabel Méndez, Braulio Quesada-Reyna, Andrea Olmos-Ortiz, Veronica Zaga-Clavellina
During pregnancy, prolactin (PRL) is a neuro-immuno-cytokine that contributes actively to the crosstalk between the immune and endocrine systems and, thus, to the creation of an immune-privileged milieu. This work aims to analyze the capacity of PRL to modulate the synthesis and secretion of pro-inflammatory markers associated with labor. Studies were conducted using human fetal membranes at term mounted in a model of two independent chambers. The choriodecidual region was stimulated with 500-ng/mL lipopolysaccharide (LPS), and the amnion and choriodecidual region were co-simulated with different concentrations of PRL that can arise during pregnancy: 250, 500, 1000, and 4000ng/mL...
September 14, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28938100/exposure-to-phthalates-in-patients-with-diabetes-and-its-association-with-oxidative-stress-adiponectin-and-inflammatory-cytokines
#9
Yishuang Duan, Lei Wang, Liping Han, Bin Wang, Hongwen Sun, Liming Chen, Lingyan Zhu, Yi Luo
Epidemiologic studies have revealed higher concentrations of the metabolites of phthalic acid esters (mPAEs) in patients with type 2 diabetes. On the other hand, oxidative stress, adiponectin, and inflammatory cytokines play important roles in the pathogenesis of diabetes and its complications. However, little information is known about the association between exposure to PAEs and these physiological parameters. Hence, paired urine and blood samples were collected from a total of 329 volunteers, and 11 main mPAEs and malondialdehyde (MDA), as a biomarker of oxidative stress, were measured in the urine samples...
September 19, 2017: Environment International
https://www.readbyqxmd.com/read/28937875/multiplex-cytokine-analysis-of-aqueous-humor-from-the-patients-with-chronic-primary-angle-closure-glaucoma
#10
Roopam Duvesh, George Puthuran, Kavitha Srinivasan, Venkatesh Rengaraj, S R Krishnadas, Sharmila Rajendrababu, Vijayakumar Balakrishnan, Pradeep Ramulu, Periasamy Sundaresan
PURPOSE: To compare the levels of cytokines and growth factor in aqueous humor of the patients with chronic primary angle closure glaucoma (PACG) and cataract. METHODS: Aqueous humor samples were collected from 19 chronic PACG patients and compared with 14 nonglaucomatous controls presenting for cataract surgery. The levels of 27 cytokines and growth factors were measured in the aqueous samples using multiplex bead immunoassay and compared across groups. RESULTS: Significantly higher levels of interleukin (IL)-8 (p < 0...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937867/coenzyme-q10-for-the-protection-of-lacrimal-gland-against-high-dose-radioiodine-therapy-associated-oxidative-damage-histopathologic-and-tissue-cytokine-level-assessments-in-an-animal-model
#11
Mehmet Yakin, Umit Eksioglu, Murat Sadic, Gokhan Koca, Guner Ozkan-Uney, Nihat Yumusak, Hande Husniye Telek, Ayten Demir, Nuray Yazihan, Firdevs Ornek, Meliha Korkmaz
PURPOSE: To evaluate protective effect of coenzyme Q10 (CoQ10) in lacrimal glands against high-dose radioactive iodine (RAI)-associated oxidative damage. MATERIALS AND METHODS: Thirty Wistar albino rats were randomly divided into three groups. Group 1 was the control group. Group 2 received 3 mCi/kg RAI via gastric gavage but no medication. Group 3 received 3 mCi/kg RAI via gastric gavage and 30 mg/kg/day CoQ10 intraperitoneally. CoQ10 was started at day one just before RAI administration and continued for five days...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937704/a-high-concentration-of-fatty-acids-induces-tnf-%C3%AE-as-well-as-no-release-mediated-by-the-p2x4-receptor-and-the-protective-effects-of-puerarin-in-raw264-7-cells
#12
Yun-Ming Tu, Cheng-Xin Gong, Lu Ding, Xing-Zi Liu, Tao Li, Fang-Fang Hu, Shuo Wang, Chao-Peng Xiong, Shang-Dong Liang, Hong Xu
Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses, which has been proposed as a potential mechanism for the development of DM and MS. P2X4 receptor (P2X4R), a ligand-gated cation channel activated by extracellular adenosine triphosphate (ATP), plays a primary role in the regulation of inflammatory responses...
September 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28937602/licochalcone-a-prevents-the-loss-of-dopaminergic-neurons-by-inhibiting-microglial-activation-in-lipopolysaccharide-lps-induced-parkinson-s-disease-models
#13
Bingxu Huang, Juxiong Liu, Chen Ju, Dongxue Yang, Guangxin Chen, Shiyao Xu, Yalong Zeng, Xuan Yan, Wei Wang, Dianfeng Liu, Shoupeng Fu
The neuroprotective effects of Licochalcone A (Lico.A), a flavonoid isolated from the herb licorice, in Parkinson's disease (PD) have not been elucidated. The prominent pathological feature of PD is the loss of dopaminergic neurons. The crucial role of neuroinflammation induced by activated microglia in dopaminergic neurodegeneration has been validated. In this study, we explore the therapeutic effects of Lico.A in lipopolysaccharide (LPS)-induced PD models in vivo and in vitro. We find that Lico.A significantly inhibits LPS-stimulated production of pro-inflammatory mediators and microglial activation by blocking the phosphorylation of extracellular signal-regulated kinase (ERK1/2) and nuclear factor κB (NF-κB) p65 in BV-2 cells...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937598/the-effect-of-rankl-opg-balance-on-reducing-implant-complications
#14
REVIEW
Elizabeth R Kapasa, Peter V Giannoudis, Xiaodong Jia, Paul V Hatton, Xuebin B Yang
Despite the phenomenal success of implants particularly in the realms of dentistry and orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection, prosthetic loosening, and non-union continue to be the most notorious examples. The cascade of fracture healing and bone repair, especially with the presence of an implant, is complex because it involves a multifaceted immune response alongside the intricate process of bone formation and remodelling. Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation, illustrating that there is a convoluted relationship between inflammation and bone erosion...
September 22, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28937552/naspghan-clinical-report-on-postoperative-recurrence-in-pediatric-crohn-disease
#15
Judy B Splawski, Marian D Pffefferkorn, Marc E Schaefer, Andrew S Day, Oliver S Soldes, Todd A Ponsky, Philip Stein, Jess L Kaplan, Shehzad A Saeed
Pediatric Crohn disease is characterized by clinical and endoscopic relapses. The inflammatory process is considered to be progressive and may lead to strictures, fistulas, and penetrating disease that may require surgery. In addition, medically refractory disease may be treated by surgical resection of inflamed bowel in an effort to reverse growth failure. The need for surgery in childhood suggests severe disease and these patients have an increased risk for recurrent disease and potentially more surgery. Data show that up to 55% of patients had clinical recurrence in the first 2 years after initial surgery...
October 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28937434/th17-response-of-borderline-lepromatous-leprosy-inhibits-rash-manifestation-of-dapsone-hypersensitivity-syndrome-case-report
#16
Tamara de Nardo Vanzela, Fred Bernardes Filho, Carlos Gustavo Wambier, Francesca Maia Faria, Norma Tiraboschi Foss, Marco Andrey Cipriani Frade
BACKGROUND: Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. OBJECTIVE: Evaluation of immunological factors involved in the sparing of borderline-lepromatous (BL) leprosy patches by the severe exanthema related to DHS. METHODS: The authors describe a 19-year-old man with borderline-lepromatous leprosy with a recent diffuse rash, sparing only the hypochromic patches of leprosy, generalized lymphadenopathy, hepatomegaly, and jaundice 25 days after the start of multibacillary multidrug therapy...
September 11, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28937237/selective-inhibition-of-nf-kappab-and-surfactant-therapy-in-experimental-meconium-induced-lung-injury
#17
J Kopincova, P Mikolka, M Kolomaznik, P Kosutova, A Calkovska, D Mokra
Meconium aspiration syndrome (MAS) in newborns is characterized mainly by respiratory failure due to surfactant dysfunction and inflammation. Previous meta-analyses did not prove any effect of exogenous surfactant treatment nor glucocorticoid administration on final outcome of children with MAS despite oxygenation improvement. As we supposed there is the need to intervene in both these fields simultaneously, we evaluated therapeutic effect of combination of exogenous surfactant and selective inhibitor of NF-kappaB (IKK-NBD peptide)...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937023/pre-illness-diet-as-risk-factor-in-pediatric-inflammatory-bowel-disease-in-saudi-arabia
#18
Mohammad I El Mouzan, Mohammad A Al Mofarreh, Ahmad A Al Sarkhy, Asaad M Assiri, Yassin M Hamed
BACKGROUND/AIM: Inflammatory bowel disease (IBD) is increasing in Saudi Arabia but there's little knowledge about its risk factors. Our aim is to investigate the dietary risk factors of this disease in Saudi children. PATIENTS AND METHODS: The children investigated for IBD were prospectively enrolled. Those with confirmed IBD were designated cases and the others were controls. The average food frequency intake at least 3 months before onset of illness was obtained by direct interview and recorded on a modified food frequency questionnaire...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28936564/adaptation-to-inflammatory-rheumatic-disease-do-illness-representations-predict-patients-physical-functioning-over-time-a-complex-relationship
#19
Evangelos C Karademas, Georgia Dimitraki, Emmanouil Papastefanakis, Georgia Ktistaki, Argyro Repa, Irini Gergianaki, George Bertsias, Prodromos Sidiropoulos, Panagiotis Simos
Patients with an inflammatory rheumatic disease (IRD), are often faced with significant limitations in physical functioning. Illness representations are a key-factor of their illness-related experience. Our aim was to examine (a) whether illness representations can predict or only reflect IRD patients' physical functioning over time, and (b) the specific pathways through which representations and physical functioning at baseline are associated with representations and functioning at follow-up. Patients with rheumatoid arthritis (N = 54) or systemic lupus erythematosus (N = 58) participated in the two phases of the study, 1 year apart...
September 21, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28936362/albumin-protein-cleavage-affects-the-wear-and-friction-of-ultra-high-molecular-weight-polyethylene
#20
Yasha Dwivedi, Michel P Laurent, Shravan Sarvepalli, Thomas M Schmid, Markus A Wimmer
It is well established that the total protein concentration and albumin-to-globulin ratio influence the wear of ultra-high molecular polyethylene (UHMWPE, "polyethylene") in joint prostheses. A factor on wear not yet studied, but of possible clinical relevance, is protein cleavage. Such cleavage is expected in the presence of an inflammatory response and as a result of wear processes at the articular interface. The aim of this study was to compare the tribological behavior of polyethylene articulated against an orthopedic wrought CoCrMo alloy for three lubricants: cleaved albumin, uncleaved albumin, and newborn calf serum (control)...
September 2017: Lubricants
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