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Keywords Diabetes Type 1.5 (Latent Auto...

Diabetes Type 1.5 (Latent Autoimmune Diabetes of Adults)

https://read.qxmd.com/read/38349399/a-novel-subpopulation-of-monocytes-with-a-strong-interferon-signature-indicated-by-siglec-1-is-present-in-patients-with-in-recent-onset-type-1-diabetes
#1
JOURNAL ARTICLE
Mengqi Guo, Han Guo, Jingjing Zhu, Fei Wang, Jianni Chen, Chuan Wan, Yujie Deng, Fang Wang, Lili Xu, Ying Chen, Ran Li, Shikai Liu, Lin Zhang, Yangang Wang, Jing Zhou, Shufa Li
AIMS/HYPOTHESIS: Type 1 diabetes is a T cell-mediated autoimmune disease characterised by pancreatic beta cell destruction. In this study, we explored the pathogenic immune responses in initiation of type 1 diabetes and new immunological targets for type 1 diabetes prevention and treatment. METHODS: We obtained peripheral blood samples from four individuals with newly diagnosed latent autoimmune diabetes in adults (LADA) and from four healthy control participants...
February 13, 2024: Diabetologia
https://read.qxmd.com/read/38333889/gad65abs-are-not-associated-with-beta-cell-dysfunction-in-patients-with-t2d-in-the-grade-study
#2
JOURNAL ARTICLE
Christiane S Hampe, Ali Shojaie, Barbara Brooks-Worrell, Sepideh Dibay, Kristina Utzschneider, Steven E Kahn, Mary E Larkin, Mary L Johnson, Naji Younes, Neda Rasouli, Cyrus Desouza, Robert M Cohen, Jean Y Park, Hermes J Florez, Willy Marcos Valencia, Robert Stempel, Jerry P Palmer, Ashok Balasubramanyam
CONTEXT: Autoantibodies directed against the 65-kilodalton isoform of glutamic acid decarboxylase (GAD65Abs) are markers of autoimmune type 1 diabetes (T1D) but are also present in patients with Latent Autoimmune Diabetes of Adults and autoimmune neuromuscular diseases, and also in healthy individuals. Phenotypic differences between these conditions are reflected in epitope-specific GAD65Abs and anti-idiotypic antibodies (anti-Id) against GAD65Abs. We previously reported that 7.8% of T2D patients in the GRADE study have GAD65Abs but found that GAD65Ab positivity was not correlated with beta-cell function, glycated hemoglobin (HbA1c), or fasting glucose levels...
January 16, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38181721/association-of-human-leukocyte-antigen-hla-footprints-with-the-comorbidity-of-latent-autoimmune-diabetes-in-adults-lada-and-hepatitis-c-virus-hcv-infection-a-multicenter-cross-sectional-study
#3
JOURNAL ARTICLE
Yujin Ding, Pan Zhang, Tuo Deng, Xiang Yan, Min Zhang, Zhiguo Xie, Gan Huang, Ping Wang, Ting Cai, Xiaoli Zhang, Xinqiang Xiao, Ying Xia, Bingwen Liu, Ya Peng, Xiaohan Tang, Min Hu, Yang Xiao, Xia Li, Erik De Clercq, Guangdi Li, Zhiguang Zhou
AIMS: This study aims to investigate the interplay between hepatitis C virus (HCV) infection and major forms of diabetes: type 1 diabetes (T1D), type 2 diabetes (T2D), and latent autoimmune diabetes in adults (LADA). METHODS: This multicenter study analyzed a cohort of 2699 diabetic and 7344 non-diabetic subjects who visited medical centers in China from 2014 to 2021. T1D, T2D, LADA, and HCV were diagnosed using standard procedures. High-throughput sequencing was conducted to identify genetic footprints of human leukocyte antigen (HLA) alleles and haplotypes at the DRB1, DQA1, and DQB1 loci...
December 29, 2023: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/38103209/does-a-prior-diagnosis-of-infectious-disease-confer-an-increased-risk-of-latent-autoimmune-diabetes-in-adults
#4
JOURNAL ARTICLE
Jessica Edstorp, Marios Rossides, Emma Ahlqvist, Bahareh Rasouli, Tiinamaija Tuomi, Sofia Carlsson
AIMS: Infections are proposed risk factors for type 1 diabetes in children. We examined whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults (LADA). MATERIALS AND METHODS: We used data from a population-based Swedish case-control study with incident cases of LADA (n = 597) and matched controls (n = 2386). The history of infectious disease was ascertained through national and regional patient registers...
December 16, 2023: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38034250/a-review-on-latent-autoimmune-diabetes-in-adults
#5
REVIEW
Vijay Ravikumar, Ariba Ahmed, Ashish Anjankar
Latent autoimmune diabetes (LADA) is an unique form of diabetes that has characteristics of both type 1 and type 2 diabetes. Type 1.5 diabetes also known as LADA is occasionally confused for type 2 diabetes because there is delay in presenting features and early insulin independence. LADA, on the other hand, is an autoimmune disorder that differs from type 2 diabetes in that autoantibodies against pancreatic beta cells are what characterise it. Insulin production eventually diminishes due to the autoimmune destruction of pancreatic beta cells as a result of the pathophysiology of LADA...
October 2023: Curēus
https://read.qxmd.com/read/37814295/clinical-characteristics-of-patients-with-early-onset-diabetes-mellitus-a-single-center-retrospective-study
#6
JOURNAL ARTICLE
Wenjing Dong, Saichun Zhang, Shiju Yan, Zhizhuang Zhao, Zengqiang Zhang, Weijun Gu
BACKGROUND: The prevalence of diabetes mellitus (DM) is dramatically increasing around the world, and patients are getting younger with changes in living standards and lifestyle. This study summarized and analyzed the clinical characteristics of different types of newly diagnosed diabetes mellitus patients with an onset age between 18 and 40 years to provide clinical evidence for the early diagnosis and treatment of diabetes, reduce short-term and long-term complications and offer scientific and personalized management strategies...
October 10, 2023: BMC Endocrine Disorders
https://read.qxmd.com/read/37584857/efficacy-of-regimens-in-the-treatment-of-latent-autoimmune-diabetes-in-adults-a-network-meta-analysis
#7
JOURNAL ARTICLE
Wanqing Wang, Fei Huang, Chunchao Han
INTRODUCTION: Latent autoimmune diabetes in adults (LADA) is a highly heterogeneous autoimmune condition with clinical and genetic characteristics that fall between those of type 1 diabetes mellitus and type 2 diabetes mellitus; therefore, there are no uniform criteria for the selection of therapeutic agents. We conducted a network meta-analysis to evaluate the efficacy of various therapeutic agents for LADA by comparing their effects on various indicators used to reflect LADA. METHODS: We searched the PubMed, Cochrane Library, Embase and Web of Science databases from their inception to March 2023 and collected data from 14 randomized controlled trials on glucose-lowering drugs for LADA, including 23 studies and 15 treatment regimens...
August 16, 2023: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/37580967/a-1-year-pilot-study-of-intralymphatic-injections-of-gad-alum-in-individuals-with-latent-autoimmune-diabetes-in-adults-lada-with-signs-of-high-immunity-no-safety-concerns-and-resemblance-to-juvenile-type-1-diabetes
#8
JOURNAL ARTICLE
Ingrid K Hals, Chandima Balasuriya, Rosaura Casas, Johnny Ludvigsson, Anneli Björklund, Valdemar Grill
AIMS: To test, for the first time in latent autoimmune diabetes in adults (LADA), the effects of autoantigen-specific immunotherapy by intralymphatic administration of aluminium-formulated recombinant human glutamic acid decarboxylase 65 (GAD-alum); specifically, to test if this treatment is safe, to test whether it induces a strong immunological response akin to a similar protocol in type 1 diabetes and to look for associations with preserved beta-cell function. MATERIALS AND METHODS: Three GAD-alum injections, 4 μg each, were administered 1 month apart into an inguinal lymph node in 14 people with newly diagnosed LADA (age 30-62 years) presenting with high levels of antibodies against glutamic acid decarboxylase (GADA)...
August 14, 2023: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/37503491/development-of-islet-antigen-2-ia2-antibodies-post-covid-19-infection-a-sign-of-autoimmunity-or-latent-autoimmune-diabetes-mellitus-in-adults-lada
#9
Nick Lee, Praveen Prabhu, Samyukta Swaminath, Sahar S Amini
Further antibody tests and laboratory studies showed that the patient met the criteria for latent autoimmune diabetes in adults (LADA). In this case report, we will review the diagnostic workup and management of LADA in an individual following his COVID-19 infection.
June 2023: Curēus
https://read.qxmd.com/read/37428296/the-worldwide-prevalence-of-latent-autoimmune-diabetes-of-adults-among-adult-onset-diabetic-individuals-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Deepika Ramu, Selvaraj Ramaswamy, Suresh Rao, Solomon F D Paul
PURPOSE: The actual global burden of Latent Autoimmune Diabetes of Adults (LADA) remains unknown even though its prevalence is almost equal to the type 1 form of diabetes. Hence the present systematic review and meta-analysis were performed to estimate the prevalence of LADA among diabetic individuals using the studies published at global levels. METHODS: A comprehensive literature revival was performed to identify articles on the prevalence of LADA published till 2023...
October 2023: Endocrine
https://read.qxmd.com/read/37421585/prevalence-of-positivity-for-diabetes-associated-autoantibodies-in-individuals-with-type-2-diabetes-and-their-further-characterisation-cross-sectional-study-from-slovakia
#11
JOURNAL ARTICLE
Mariana Rončáková, Arash Davani, Veronika Mikušová, Ivana Ságová, Peter Novodvorský, Emil Martinka
BACKGROUND: Individuals initially diagnosed with type 2 diabetes (T2D) might exhibit positivity for diabetes-associated autoantibodies (DAA +). We investigated the prevalence of DAA positivity in a group of individuals with T2D who were referred to a tertiary diabetes centre within a pre-specified period of time. We aimed to identify characteristics linked with DAA positivity by comparing DAA + individuals with their DAA-negative counterparts. METHODS: This was a cross-sectional study into which all T2D patients referred to the National Institute of Endocrinology and Diabetology, Ľubochňa, Slovakia, between 1 January and 30 June 2016 were included...
July 8, 2023: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/37120620/identification-and-phenotypic-characterization-of-patients-with-lada-in-a-population-of-southeast-mexico
#12
JOURNAL ARTICLE
Germán Alberto Nolasco-Rosales, Dania Ramírez-González, Ester Rodríguez-Sánchez, Ángela Ávila-Fernandez, Guillermo Efrén Villar-Juarez, Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Crystell Guadalupe Guzmán-Priego, Alma Delia Genis-Mendoza, Jorge Luis Ble-Castillo, Alejandro Marín-Medina, Isela Esther Juárez-Rojop
Latent autoimmune diabetes in adults (LADA) has clinical and metabolic features of type 1 and type 2 diabetes. LADA does not have specific features for its diagnosis apart from autoantibody detection; however, these tests are not affordable in clinical settings. In this cross-sectional study, we analyzed clinical criteria, metabolic control, pharmacological treatment, and diabetic complications in two groups of patients with diabetes -LADA and T2D- in order to identify specific characteristic of these clinical entities...
April 29, 2023: Scientific Reports
https://read.qxmd.com/read/36991252/consensus-paper-latent-autoimmune-cerebellar-ataxia-laca
#13
JOURNAL ARTICLE
Mario Manto, Marios Hadjivassiliou, José Fidel Baizabal-Carvallo, Christiane S Hampe, Jerome Honnorat, Bastien Joubert, Hiroshi Mitoma, Sergio Muñiz-Castrillo, Aasef G Shaikh, Alberto Vogrig
Immune-mediated cerebellar ataxias (IMCAs) have diverse etiologies. Patients with IMCAs develop cerebellar symptoms, characterized mainly by gait ataxia, showing an acute or subacute clinical course. We present a novel concept of latent autoimmune cerebellar ataxia (LACA), analogous to latent autoimmune diabetes in adults (LADA). LADA is a slowly progressive form of autoimmune diabetes where patients are often initially diagnosed with type 2 diabetes. The sole biomarker (serum anti-GAD antibody) is not always present or can fluctuate...
March 29, 2023: Cerebellum
https://read.qxmd.com/read/36867461/incidence-of-lada-and-type-2-diabetes-in-relation-to-tobacco-use-and-genetic-susceptibility-to-type-2-diabetes-and-related-traits-findings-from-a-swedish-case-control-study-and-the-norwegian-hunt-study
#14
JOURNAL ARTICLE
Jessica Edstorp, Emma Ahlqvist, Lars Alfredsson, Dina Mansour Aly, Valdemar Grill, Bahareh Rasouli, Elin P Sørgjerd, Tiinamaija Tuomi, Bjørn O Åsvold, Sofia Carlsson
OBJECTIVE: Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) aggravate these associations. RESEARCH DESIGN AND METHODS: We used data from two population-based Scandinavian studies with case subjects with LADA (n = 839) and T2D (n = 5,771), matched control subjects (n = 3,068), and 1,696,503 person-years at risk...
March 3, 2023: Diabetes Care
https://read.qxmd.com/read/36750915/retinal-microvascular-markers-in-type-2-diabetes-subphenotypes-and-latent-autoimmune-diabetes-of-adults
#15
JOURNAL ARTICLE
Frederik N Pedersen, Jacob V Stidsen, Martin N Rasmussen, Henning-Beck Nielsen, Jan Erik Henriksen, Thomas Bastholm Olesen, Michael Hecht Olsen, Jens S Nielsen, Kurt Højlund, Søren Leer Blindbaek, Jakob Grauslund
PURPOSE: To estimate if newly diagnosed patients with different subphenotypes of type 2 diabetes (T2DM) or latent autoimmune diabetes of adults (LADA) differ with respect to subclinical retinal microvascular structure or diabetic retinopathy (DR). METHODS: This population-based, cross-sectional study of 340 patients (675 eyes) classified patients with recently diagnosed T2DM in different subphenotypes according to beta cell function and insulin sensitivity in to; classical (n = 218), hyperinsulinaemic (n = 86), insulinopenic (n = 20), or LADA (n = 16)...
February 7, 2023: Acta Ophthalmologica
https://read.qxmd.com/read/36717991/when-serum-c-peptide-measurement-drives-adequate-diabetes-mellitus-diagnosis-and-therapy-a-case-report
#16
Giuseppe Lisco, Sara Volpe, Domenico Triggiani, Vincenzo Triggiani, Giuseppina Piazzolla
BACKGROUND: Therapeutic targets in type 2 diabetes mellitus (T2D) are oriented towards nephron- and cardio-protection and the prescription of antihyperglycemic agents with proven renal and cardiovascular benefits are increasing over time. Failure to promptly diagnose insulinopenic diabetes may adversely affect the adequacy of treatment and have harmful consequences, including severe hyperglycemia and diabetic ketoacidosis. CASE REPORT: Herein we present the case of a 57-year-old woman referred to our clinic due to poor glycemic control (HbA1c 80 mmol/mol, therapeutic target <53 mmol/mol), class III obesity (BMI 41 kg/m2; normal value <25 kg/m2), and high cardiovascular risk misdiagnosed with T2D several years before...
January 30, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/36627022/correlation-between-hemoglobin-glycation-index-measured-by-continuous-glucose-monitoring-with-complications-in-type-1-diabetes
#17
JOURNAL ARTICLE
Raul Ibarra-Salce, Francisco Javier Pozos-Varela, Nestor Martinez-Zavala, Cesar Ernesto Lam-Chung, Tania Sofia Mena-Ureta, Marcela Janka-Zires, Raquel N Faradji, Juan Ramon Madrigal-Sanroman, Natalia Eloisa de la Garza-Hernandez, Paloma Almeda-Valdes
OBJECTIVE: HbA1C is the "gold standard" parameter to evaluate glycemic control in diabetes; however, its correlation with mean glucose is not always perfect. The objective of this study was to correlate continuous glucose monitoring (CGM)-derived hemoglobin glycation index (HGI) with microvascular complications. METHODS: We conducted a cross-sectional study including permanent users of CGM with type 1 diabetes mellitus or latent autoimmune diabetes of the adult...
January 7, 2023: Endocrine Practice
https://read.qxmd.com/read/36268330/diagnostic-camouflage-a-case-report-on-latent-autoimmune-diabetics-of-adulthood
#18
Sandhya Kiran Neupane, Prakash Paudel Jaishi, Divyaa Koirala, Arjun Kandel, Prabhat Kiran Neupane
INTRODUCTION AND IMPORTANCE: Latent autoimmune diabetes of adulthood is an autoimmune disease sharing similarities of type 1 and type 2 diabetics. It is also known as type 1.5 diabetes in adults. It occurs mostly at the age of 30-35 years. It is usually associated with other autoimmune diseases and patients usually have normal BMI. Patients are positive for glutamic acid dehydrogenase and islets cell autoantibodies with onset in adulthood. CASE: We present a case of a 42 year old female from the capital city of Nepal who presented with chief complaints of excessive thirst and increased frequency of micturition...
October 2022: Annals of Medicine and Surgery
https://read.qxmd.com/read/36111021/thyroid-autoantibody-distribution-in-patients-with-latent-autoimmune-diabetes-in-youth-a-multicenter-national-survey
#19
JOURNAL ARTICLE
Xixi Nan, Xia Li, Yufei Xiang, Xiang Yan, Houde Zhou, Xiaohan Tang, Jin Cheng, Xiaohong Niu, Jing Liu, Qiuhe Ji, Linong Ji, Gan Huang, Zhiguang Zhou
Background: A high seropositive rate of thyroid autoantibodies is often reported in patients with type 1 diabetes mellitus (T1DM), latent autoimmune diabetes in adults (LADA) and type 2 diabetes mellitus (T2DM). However, the positive rate of thyroid autoantibodies in latent autoimmune diabetes in youth (LADY) patients has not been reported in China. Thus, the purpose of the current study was to clarify the thyroid autoantibody distribution in patients with LADY to provide evidence for the clinical screening of autoimmune thyroid diseases (AITD)...
August 2022: Annals of Translational Medicine
https://read.qxmd.com/read/36090989/latent-autoimmune-diabetes-in-adults-in-china
#20
REVIEW
Junlin Qiu, Zilin Xiao, Ziwei Zhang, Shuoming Luo, Zhiguang Zhou
Latent autoimmune diabetes in adults (LADA) is a type of diabetes caused by slow progression of autoimmune damage to pancreatic beta cells. According to the etiological classification, LADA should belong to the autoimmune subtype of type 1 diabetes (T1D). Previous studies have found general immune genetic effects associated with LADA, but there are also some racial differences. Multicenter studies have been conducted in different countries worldwide, but it is still unclear how the Chinese and Caucasian populations differ...
2022: Frontiers in Immunology
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