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https://www.readbyqxmd.com/read/29219636/physiological-effects-of-brominated-flame-retardants-on-nc-nga-mice
#1
Michitaka Tanaka, Ken-Ichiro Inoue, Akinori Shimada, Hirohisa Takano
PURPOSE: Brominated flame retardants (BFRs) are used as an additive or reactive components in various materials. Regarding their health concerns, their immunotoxicity have not been clarified yet. MATERIALS AND METHODS: In the current study, we examined the effects of systemic exposure to two types of BFRs, DE71 and DE79, on pathophysiologic traits of murine atopic dermatitis (AD). Male NC/Nga mice were repeatedly injected intraperitoneally with DE71 and DE79 and/or mite allergen (Dermatophagoides pteronyssinus: Dp) into their right ears...
December 8, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29216539/influence-of-extracellular-environment-on-the-motility-and-structural-properties-of-spermatozoa-collected-from-hormonally-stimulated-panamanian-golden-frog-atelopus-zeteki
#2
Gina Della Togna, Brian Gratwicke, Matthew Evans, Lauren Augustine, Han Chia, Ed Bronikowski, James B Murphy, Pierre Comizzoli
A better understanding of the factors influencing the biology of amphibian spermatozoa after release from the testis is a prerequisite to the development of sperm preservation methods. The objective of the study was to determine the effect of extracellular conditions (exposure to water and different temperatures) over time on the sperm motility and structural properties (including morphology and DNA integrity) collected from hormonally stimulated Atelopus zeteki. Following intraperitoneal injection of gonadotropin-releasing hormone agonist (des-Gly10, D-Ala6, Pro-NHEt9 GnRH; 4 μg/g of body weight), human chorionic gonadotropin (hCG, 10 IU/gbw), or Amphiplex™ (0...
November 29, 2017: Theriogenology
https://www.readbyqxmd.com/read/29146150/the-effect-of-cold-acclimation-on-active-ion-transport-in-cricket-ionoregulatory-tissues
#3
Lauren E Des Marteaux, Soheila Khazraeenia, Gil Y Yerushalmi, Andrew Donini, Natalia G Li, Brent J Sinclair
Cold-acclimated insects defend ion and water transport function during cold exposure. We hypothesized that this is achieved via enhanced active transport. The Malpighian tubules and rectum are likely targets for such transport modifications, and recent transcriptomic studies indicate shifts in Na(+)-K(+) ATPase (NKA) and V-ATPase expression in these tissues following cold acclimation. Here we quantify the effect of cold acclimation (one week at 12°C) on active transport in the ionoregulatory organs of adult Gryllus pennsylvanicus field crickets...
November 13, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29124779/prenatal-diethylstilbestrol-exposure-and-cancer-risk-in-women
#4
Rebecca Troisi, Elizabeth E Hatch, Linda Titus, William Strohsnitter, Mitchell H Gail, Dezheng Huo, Ervin Adam, Stanley J Robboy, Marianne Hyer, Robert N Hoover, Julie R Palmer
In the Diethylstilbestrol [DES] Combined Cohort Follow-up, the age- and calendar-year specific standardized incidence ratio [SIR] for clear cell adenocarcinoma [CCA] was 27.6 (95% confidence interval [CI] 7.51-70.6) for the exposed women. The SIR for breast cancer was 1.17 (95% CI 1.01-1.36) and the hazard ratio [HR] adjusted for birth year and cohort for comparison with the unexposed was 1.05 (95% CI 0.79-1.41). The SIR for pancreatic cancer was 2.43 (95% CI 1.21-4.34) and the adjusted HR for comparison with unexposed women was 7...
November 10, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29081918/seroprevalence-and-risk-factors-for-peste-des-petits-ruminants-and-selected-differential-diagnosis-in-sheep-and-goats-in-tanzania
#5
Emeli Torsson, Mikael Berg, Gerald Misinzo, Ida Herbe, Tebogo Kgotlele, Malin Päärni, Nils Roos, Anne-Lie Blomström, Karl Ståhl, Jonas Johansson Wensman
Introduction: Livestock husbandry is critical for food security and poverty reduction in a low-income country like Tanzania. Infectious disease is one of the major constraints reducing the productivity in this sector. Peste des petits ruminants (PPR) is one of the most important diseases affecting small ruminants, but other infectious diseases may also be present. Objective: The objective of this study was to determine the seroprevalence and risk factors for exposure to PPR, contagious caprine pleuropneumonia (CCPP), foot-and-mouth disease (FMD), bluetongue (BT), and bovine viral diarrhoea (BVD) in sheep and goats in Tanzania...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/29069384/a-prospective-cohort-study-of-prenatal-diethylstilbestrol-exposure-and-cardiovascular-disease-risk
#6
Rebecca Troisi, Linda Titus, Elizabeth E Hatch, Julie R Palmer, Dezheng Huo, William C Strohsnitter, Ervin Adam, Winnie Ricker, Marianne Hyer, Robert N Hoover
Purpose: Prenatal exposure to diethylstilbestrol (DES), a prototype endocrine disrupting chemical, is associated with risk of adverse reproductive outcomes and cancer in women. We investigated whether cardiovascular disease (CVD) risk might also be greater in prenatally DES exposed women. Methods: DES exposed (n=3941) and unexposed (n=1705) women participating in the Diethylstilbestrol Combined Cohort Follow-up Study were followed prospectively from 1994-2013. Prenatal DES exposure (or lack of exposure) was documented in the birth record or physician's note...
October 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29066032/-night-workers-exposure-to-harshness-factors-in-france-lessons-learned-from-the-2010%C3%A2-sumer-survey
#7
N Havet, M Huguet, J Tonietta
BACKGROUND: Despite the fact that French laws state that night work should be exceptional, the number of night workers has sharply increased in the past 20 years. At the same time, empirical and epidemiological studies indicate that night work has negative effects on workers' health. This is why the 2010 French pension act considered night work to be a drudgery. The aim of this study is to investigate whether night workers are more subject to other factors defined as contributing to the drudgery of work than are day workers...
November 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29051608/transcription-factors-and-stress-response-gene-alterations-in-human-keratinocytes-following-solar-simulated-ultra-violet-radiation
#8
Thomas L Des Marais, Thomas Kluz, Dazhong Xu, Xiaoru Zhang, Lisa Gesumaria, Mary S Matsui, Max Costa, Hong Sun
Ultraviolet radiation (UVR) from sunlight is the major effector for skin aging and carcinogenesis. However, genes and pathways altered by solar-simulated UVR (ssUVR), a mixture of UVA and UVB, are not well characterized. Here we report global changes in gene expression as well as associated pathways and upstream transcription factors in human keratinocytes exposed to ssUVR. Human HaCaT keratinocytes were exposed to either a single dose or 5 repetitive doses of ssUVR. Comprehensive analyses of gene expression profiles as well as functional annotation were performed at 24 hours post irradiation...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29028249/a-method-to-quantitatively-assess-dermal-exposure-to-volatile-organic-compounds
#9
Matteo Creta, Katrien Poels, Laurens Thoelen, Karine Vranckx, Peter Collaerts, Fleur Jansen, Michel Vangeel, Lode Godderis, Radu-Corneliu Duca, Jeroen A J Vanoirbeek
Assessing dermal exposure of workers to noxious chemicals becomes increasingly important in industrial settings. Among various chemicals, volatile organic compounds (VOCs) are widely used in industrialized countries, but still there are no validated methodologies able to accurately quantify skin exposure. In this study, we developed a sensitive methodology based on activated charcoal cloth (ACC) to quantitatively assess skin exposure to 181 VOCs. The majority of the VOCs (156) showed a constant desorption efficiency (DE) of ~100% over the studied concentration range...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28990450/revisiting-the-role-of-durable-polymers-in-cardiovascular-devices
#10
Hiroyoshi Mori, Fumiyuki Otsuka, Anuj Gupta, Hiroyuki Jinnouchi, Sho Torii, Emanuel Harari, Renu Virmani, Aloke V Finn
Polymers are an essential component of drug-eluting stents (DES) used to control drug release but remain the most controversial component of DES technology. There are two types of polymers employed in DES: durable polymer based DES (DP-DES) and biodegradable polymer DES (BP-DES). First-generation DES were exclusively composed of DP and demonstrated increased rates of late stent failure due in part to poor polymer biocompatibility. Newer generations DES use more biocompatible durable polymers or biodegradable polymers...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28960386/diethylstilbestrol-impaired-oogenesis-of-yellow-catfish-juveniles-through-disrupting-hypothalamic-pituitary-gonadal-axis-and-germ-cell-development
#11
Yaqin Wang, Yingwen Li, Qiliang Chen, Zhihao Liu
Diethylstilbestrol (DES), a non-steroidal estrogen, has been found to cause altered germ cell development and disordered ovarian development in fish females. However, the mechanisms that might be involved are poorly understood. In this study, female juveniles of yellow catfish (Pelteobagrus fulvidraco) (120 days post-hatching) were exposed to two doses (10 and 100 ng l(-1) ) of DES for 28 days. After the endpoint of exposure, decreased ovary weight and gonadosomatic index, as well as various ovarian impairments were observed in response to DES...
September 28, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28945747/establishment-of-primary-mixed-cell-cultures-from-spontaneous-canine-mammary-tumors-characterization-of-classic-and-new-cancer-associated-molecules
#12
Luciana B Gentile, Marcia K Nagamine, Luiz R Biondi, Daniel S Sanches, Fábio Toyota, Tatiane M Giovani, Isis P de Jesus, Ivone I M da Fonseca, Nicolle Queiroz-Hazarbassanov, Bruno L Diaz, Cristina de O Massoco Salles Gomes, Maria Lucia Z Dagli
There are many factors which make canine cancer like cancer in humans. The occurrence of spontaneous mammary tumors in pet dogs, tumor genetics, molecular targets and exposure to the same environmental risk factors are among these factors. Therefore, the study of canine cancer can provide useful information to the oncology field. This study aimed to establish and characterize a panel of primary mixed cell cultures obtained from spontaneous canine mammary tumors. Eight established cell cultures obtained from one normal mammary gland, one complex adenoma, one mixed adenoma, two complex carcinomas and two mixed carcinomas were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28937961/regulation-of-chromatin-assembly-and-cell-transformation-by-formaldehyde-exposure-in-human-cells
#13
Danqi Chen, Lei Fang, Shenglin Mei, Hongjie Li, Xia Xu, Thomas L Des Marais, Kun Lu, X Shirley Liu, Chunyuan Jin
BACKGROUND: Formaldehyde (FA) is an environmental and occupational chemical carcinogen. Recent studies have shown that exogenous FA causes only a modest increase in DNA adduct formation compared with the amount of adducts formed by endogenous FA, raising the possibility that epigenetic mechanisms may contribute to FA-mediated carcinogenicity. OBJECTIVES: We investigated the effects of FA exposure on histone modifications and chromatin assembly. We also examined the role of defective chromatin assembly in FA-mediated transcription and cell transformation...
September 21, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934727/in-utero-exposure-to-select-phenols-and-phthalates-and-respiratory-health-in-five-year-old-boys-a-prospective-study
#14
Céline Vernet, Isabelle Pin, Lise Giorgis-Allemand, Claire Philippat, Meriem Benmerad, Joane Quentin, Antonia M Calafat, Xiaoyun Ye, Isabella Annesi-Maesano, Valérie Siroux, Rémy Slama
BACKGROUND: Phenols and phthalates may have immunomodulatory and proinflammatory effects and thereby adversely affect respiratory health. OBJECTIVE: We estimated the associations between gestational exposure to select phthalates and phenols and respiratory health in boys. METHODS: Among 587 pregnant women from the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l'Enfant) cohort who delivered a boy, 9 phenols and 11 phthalates metabolites were quantified in spot pregnancy urine samples...
September 8, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28925920/low-radon-exposure-and-mortality-among-jouac-uranium-miners-an-update-of-the-french-cohort-1946-2007
#15
Estelle Rage, Sylvaine Caër-Lorho, Dominique Laurier
After the extension of the French cohort of uranium miners with the inclusion of workers employed in the Jouac mines, this article seeks to describe the new Jouac cohort and to estimate mortality risks, as well as to quantify their relation to radon exposure in this extended cohort. The Jouac cohort includes 458 miners hired by the Société des Mines de Jouac between 1957 and 2001. As there is no measurement of radon exposure before 1978 were unavailable, only the post-1977 Jouac cohort (n=314) has been included in the French cohort, creating an extended cohort of 5400 French uranium miners followed up from 1946 to 2007...
September 19, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28894883/-indoor-air-guide-value-for-propan-1-2-diol-propylene-glycol-communication-from-the-committee-on-indoor-guide-values
#16
(no author information available yet)
The Committee on Indoor Guide Values is issuing indoor air guide values to protect public health. At present, no suitable human studies are available for health evaluation of propan-1,2-diol in indoor air. In a well-documented subchronic inhalation animal study with rats, assessed as reliable, nasal hemorrhages were observed. This study leads to a LOAEC of 28.6 mg/m3 propan-1,2-diol for continuous exposure for the endpoint nasal hemorrhages. By applying a conversion factor of 2 from subchronic to chronic exposure, an interspecies factor of 2...
September 11, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28877873/the-in-vitro-zebrafish-heart-as-a-model-to-investigate-the-chronotropic-effects-of-vapor-anesthetics
#17
Matthew R Stoyek, Michael K Schmidt, Florentin M Wilfart, Roger P Croll, Frank M Smith
In addition to their intended clinical actions, all general anesthetic agents in common use have detrimental intra- and post-surgical side effects on organs and systems including the heart. The major cardiac side effect of anesthesia is bradycardia, which increases the probability of insufficient systemic perfusion during surgery. These side effects also occur in all vertebrate species so far examined, but the underlying mechanisms are not clear. The zebrafish heart is a powerful model for studying cardiac electrophysiology, employing the same pacemaker system and neural control as do mammalian hearts...
September 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28843140/prenatal-and-postnatal-exposure-to-organophosphate-pesticides-and-childhood-neurodevelopment-in-shandong-china
#18
Yiwen Wang, Yan Zhang, Lin Ji, Yi Hu, Jingjing Zhang, Caifeng Wang, Guodong Ding, Limei Chen, Michihiro Kamijima, Jun Ueyama, Yu Gao, Ying Tian
BACKGROUND: Although studies in laboratory animals demonstrate neurodevelopmental deficits caused by prenatal or postnatal organophosphate pesticide (OP) exposure, there is limited evidence on effects induced by not only prenatal but also postnatal exposure of children to OPs. METHODS: We measured diethylphosphate (DE), dimethylphosphate (DM), and total dialkylphosphate (DAP) metabolites in maternal and child urine at 12 and 24months of age and examined their relationship with developmental quotients (DQs) in 12-month-old infants and 24-month-old children in Shandong, China...
August 23, 2017: Environment International
https://www.readbyqxmd.com/read/28838471/risk-of-early-adverse-events-after-clopidogrel-discontinuation-in-patients-undergoing-short-term-dual%C3%A2-antiplatelet%C3%A2-therapy-an-individual-participant-data-analysis
#19
Raffaele Piccolo, Fausto Feres, Alexandre Abizaid, Martine Gilard, Marie-Claude Morice, Myeong-Ki Hong, Hyo-Soo Kim, Antonio Colombo, Deepak L Bhatt, Tullio Palmerini, Gregg W Stone, Stephan Windecker, Marco Valgimigli
OBJECTIVES: The study sought to evaluate the presence of a clinically relevant rebound phenomenon after dual antiplatelet therapy (DAPT) discontinuation in randomized trials. BACKGROUND: It is currently unknown whether clopidogrel discontinuation after short-term DAPT is associated with an early hazard of ischemic events. METHODS: The authors performed an individual participant data analysis and aggregate meta-analysis. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as the composite of cardiac death, myocardial infarction (MI), or stroke...
August 28, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28835173/taking-account-of-gender-differences-when-designing-interventions-in-occupational-health-lessons-from-a-study-of-the-healthy-enterprise-standard-in-qu%C3%A3-bec-les-diff%C3%A3-rences-de-genre-sont-elles-prises-en-compte-lors-de-la-conception-des-interventions-de-pr%C3%A3
#20
Hélène Sultan-Taïeb, France St-Hilaire, Rébecca Lefebvre, Caroline Biron, Michel Vézina, Chantal Brisson
The literature shows substantial differences in occupational exposures between men and women, both between and within occupations, but remains very sparse on whether interventions are tailored to gender differences in the workplace. Our objective was to determine whether gender differences are taken into account when designing prevention interventions. This study is part of a project on the evaluation of interventions implemented in the framework of the "Healthy Enterprise" standard in Quebec organizations...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
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