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DES Exposure

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https://www.readbyqxmd.com/read/29028249/a-method-to-quantitatively-assess-dermal-exposure-to-volatile-organic-compounds
#1
Matteo Creta, Katrien Poels, Laurens Thoelen, Karine Vranckx, Peter Collaerts, Fleur Jansen, Michel Vangeel, Lode Godderis, Radu-Corneliu Duca, Jeroen A J Vanoirbeek
Assessing dermal exposure of workers to noxious chemicals becomes increasingly important in industrial settings. Among various chemicals, volatile organic compounds (VOCs) are widely used in industrialized countries, but still there are no validated methodologies able to accurately quantify skin exposure. In this study, we developed a sensitive methodology based on activated charcoal cloth (ACC) to quantitatively assess skin exposure to 181 VOCs. The majority of the VOCs (156) showed a constant desorption efficiency (DE) of ~100% over the studied concentration range...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28990450/revisiting-the-role-of-durable-polymers-in-cardiovascular-devices
#2
Hiroyoshi Mori, Fumiyuki Otsuka, Anuj Gupta, Hiroyuki Jinnouchi, Sho Torii, Emanuel Harari, Renu Virmani, Aloke V Finn
Polymers are an essential component of drug-eluting stents (DES) used to control drug release but remain the most controversial component of DES technology. There are two types of polymers employed in DES: durable polymer based DES (DP-DES) and biodegradable polymer DES (BP-DES). First-generation DES were exclusively composed of DP and demonstrated increased rates of late stent failure due in part to poor polymer biocompatibility. Newer generations DES use more biocompatible durable polymers or biodegradable polymers...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28960386/diethylstilbestrol-impaired-oogenesis-of-yellow-catfish-juveniles-through-disrupting-hypothalamic-pituitary-gonadal-axis-and-germ-cell-development
#3
Yaqin Wang, Yingwen Li, Qiliang Chen, Zhihao Liu
Diethylstilbestrol (DES), a non-steroidal estrogen, has been found to cause altered germ cell development and disordered ovarian development in fish females. However, the mechanisms that might be involved are poorly understood. In this study, female juveniles of yellow catfish (Pelteobagrus fulvidraco) (120 days post-hatching) were exposed to two doses (10 and 100 ng l(-1) ) of DES for 28 days. After the endpoint of exposure, decreased ovary weight and gonadosomatic index, as well as various ovarian impairments were observed in response to DES...
September 28, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28945747/establishment-of-primary-mixed-cell-cultures-from-spontaneous-canine-mammary-tumors-characterization-of-classic-and-new-cancer-associated-molecules
#4
Luciana B Gentile, Marcia K Nagamine, Luiz R Biondi, Daniel S Sanches, Fábio Toyota, Tatiane M Giovani, Isis P de Jesus, Ivone I M da Fonseca, Nicolle Queiroz-Hazarbassanov, Bruno L Diaz, Cristina de O Massoco Salles Gomes, Maria Lucia Z Dagli
There are many factors which make canine cancer like cancer in humans. The occurrence of spontaneous mammary tumors in pet dogs, tumor genetics, molecular targets and exposure to the same environmental risk factors are among these factors. Therefore, the study of canine cancer can provide useful information to the oncology field. This study aimed to establish and characterize a panel of primary mixed cell cultures obtained from spontaneous canine mammary tumors. Eight established cell cultures obtained from one normal mammary gland, one complex adenoma, one mixed adenoma, two complex carcinomas and two mixed carcinomas were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28937961/regulation-of-chromatin-assembly-and-cell-transformation-by-formaldehyde-exposure-in-human-cells
#5
Danqi Chen, Lei Fang, Shenglin Mei, Hongjie Li, Xia Xu, Thomas L Des Marais, Kun Lu, X Shirley Liu, Chunyuan Jin
BACKGROUND: Formaldehyde (FA) is an environmental and occupational chemical carcinogen. Recent studies have shown that exogenous FA causes only a modest increase in DNA adduct formation compared with the amount of adducts formed by endogenous FA, raising the possibility that epigenetic mechanisms may contribute to FA-mediated carcinogenicity. OBJECTIVES: We investigated the effects of FA exposure on histone modifications and chromatin assembly. We also examined the role of defective chromatin assembly in FA-mediated transcription and cell transformation...
September 21, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934727/in-utero-exposure-to-select-phenols-and-phthalates-and-respiratory-health-in-five-year-old-boys-a-prospective-study
#6
Céline Vernet, Isabelle Pin, Lise Giorgis-Allemand, Claire Philippat, Meriem Benmerad, Joane Quentin, Antonia M Calafat, Xiaoyun Ye, Isabella Annesi-Maesano, Valérie Siroux, Rémy Slama
BACKGROUND: Phenols and phthalates may have immunomodulatory and proinflammatory effects and thereby adversely affect respiratory health. OBJECTIVE: We estimated the associations between gestational exposure to select phthalates and phenols and respiratory health in boys. METHODS: Among 587 pregnant women from the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l'Enfant) cohort who delivered a boy, 9 phenols and 11 phthalates metabolites were quantified in spot pregnancy urine samples...
September 8, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28925920/low-radon-exposure-and-mortality-among-jouac-uranium-miners-an-update-of-the-french-cohort-1946-2007
#7
Estelle Rage, Sylvaine Caër-Lorho, Dominique Laurier
After the extension of the French cohort of uranium miners with the inclusion of workers employed in the Jouac mines, this article seeks to describe the new Jouac cohort and to estimate mortality risks, as well as to quantify their relation to radon exposure in this extended cohort. The Jouac cohort includes 458 miners hired by the Société des Mines de Jouac between 1957 and 2001. As there is no measurement of radon exposure before 1978 were unavailable, only the post-1977 Jouac cohort (n=314) has been included in the French cohort, creating an extended cohort of 5400 French uranium miners followed up from 1946 to 2007...
September 19, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28894883/-indoor-air-guide-value-for-propan-1-2-diol-propylene-glycol-communication-from-the-committee-on-indoor-guide-values
#8
(no author information available yet)
The Committee on Indoor Guide Values is issuing indoor air guide values to protect public health. At present, no suitable human studies are available for health evaluation of propan-1,2-diol in indoor air. In a well-documented subchronic inhalation animal study with rats, assessed as reliable, nasal hemorrhages were observed. This study leads to a LOAEC of 28.6 mg/m3 propan-1,2-diol for continuous exposure for the endpoint nasal hemorrhages. By applying a conversion factor of 2 from subchronic to chronic exposure, an interspecies factor of 2...
September 11, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28877873/the-in-vitro-zebrafish-heart-as-a-model-to-investigate-the-chronotropic-effects-of-vapor-anesthetics
#9
Matthew R Stoyek, Michael K Schmidt, Florentin M Wilfart, Roger P Croll, Frank M Smith
In addition to their intended clinical actions, all general anesthetic agents in common use have detrimental intra- and post-surgical side effects on organs and systems including the heart. The major cardiac side effect of anesthesia is bradycardia, which increases the probability of insufficient systemic perfusion during surgery. These side effects also occur in all vertebrate species so far examined, but the underlying mechanisms are not clear. The zebrafish heart is a powerful model for studying cardiac electrophysiology, employing the same pacemaker system and neural control as do mammalian hearts...
September 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28843140/prenatal-and-postnatal-exposure-to-organophosphate-pesticides-and-childhood-neurodevelopment-in-shandong-china
#10
Yiwen Wang, Yan Zhang, Lin Ji, Yi Hu, Jingjing Zhang, Caifeng Wang, Guodong Ding, Limei Chen, Michihiro Kamijima, Jun Ueyama, Yu Gao, Ying Tian
BACKGROUND: Although studies in laboratory animals demonstrate neurodevelopmental deficits caused by prenatal or postnatal organophosphate pesticide (OP) exposure, there is limited evidence on effects induced by not only prenatal but also postnatal exposure of children to OPs. METHODS: We measured diethylphosphate (DE), dimethylphosphate (DM), and total dialkylphosphate (DAP) metabolites in maternal and child urine at 12 and 24months of age and examined their relationship with developmental quotients (DQs) in 12-month-old infants and 24-month-old children in Shandong, China...
August 23, 2017: Environment International
https://www.readbyqxmd.com/read/28838471/risk-of-early-adverse-events-after-clopidogrel-discontinuation-in-patients-undergoing-short-term-dual%C3%A2-antiplatelet%C3%A2-therapy-an-individual-participant-data-analysis
#11
Raffaele Piccolo, Fausto Feres, Alexandre Abizaid, Martine Gilard, Marie-Claude Morice, Myeong-Ki Hong, Hyo-Soo Kim, Antonio Colombo, Deepak L Bhatt, Tullio Palmerini, Gregg W Stone, Stephan Windecker, Marco Valgimigli
OBJECTIVES: The study sought to evaluate the presence of a clinically relevant rebound phenomenon after dual antiplatelet therapy (DAPT) discontinuation in randomized trials. BACKGROUND: It is currently unknown whether clopidogrel discontinuation after short-term DAPT is associated with an early hazard of ischemic events. METHODS: The authors performed an individual participant data analysis and aggregate meta-analysis. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as the composite of cardiac death, myocardial infarction (MI), or stroke...
August 28, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28835173/taking-account-of-gender-differences-when-designing-interventions-in-occupational-health-lessons-from-a-study-of-the-healthy-enterprise-standard-in-qu%C3%A3-bec-les-diff%C3%A3-rences-de-genre-sont-elles-prises-en-compte-lors-de-la-conception-des-interventions-de-pr%C3%A3
#12
Hélène Sultan-Taïeb, France St-Hilaire, Rébecca Lefebvre, Caroline Biron, Michel Vézina, Chantal Brisson
The literature shows substantial differences in occupational exposures between men and women, both between and within occupations, but remains very sparse on whether interventions are tailored to gender differences in the workplace. Our objective was to determine whether gender differences are taken into account when designing prevention interventions. This study is part of a project on the evaluation of interventions implemented in the framework of the "Healthy Enterprise" standard in Quebec organizations...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28734970/genetic-variation-in-low-dose-effects-of-neonatal-des-exposure-in-female-rats
#13
Hideo Ohmukai, Tsukasa Negura, Shigehiro Tachibana, Ryo Ohta
To confirm genetic variation in low-dose effects of diethylstilbestrol (DES), two inbred strains of rats, which have been selectively bred for high- and low-avoidance learning (HAA and LAA, respectively), were used in this study. LAA rats characteristically show later sexual maturation, earlier reproductive senescence, and lower body weight as compared to HAA rats. Female neonates of each strain were daily administered DES by oral gavage at doses of 0 (vehicle only), 0.05 and 0.5μg/kg for the first 5days after birth...
July 19, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28734242/environmental-estrogen-s-induced-swimming-behavioural-alterations-in-adult-zebrafish-danio-rerio
#14
Basavaraj B Goundadkar, Pancharatna Katti
The present study is an attempt to investigate the effects of long-term (75days) exposure to environmental estrogens (EE) on the swimming behaviour of zebrafish (Danio rerio). Adult zebrafish were exposed semi-statically to media containing commonly detected estrogenic water contaminants (EE2, DES and BPA) at a concentration (5ng/L) much lower than environmentally recorded levels. Time spent in swimming, surface preference, patterns and path of swimming were recorded (6mins) for each fish using two video cameras on day 15, 30 60 and 75...
July 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28731889/stent-thrombosis-with-bioabsorbable-polymer-drug-eluting-stents-insights-from-the-food-and-drug-administration-database
#15
Abdur R Khan, Avnish Tripathi, Talha A Farid, Bilal Abaid, Deepak L Bhatt, Jon R Resar, Michael P Flaherty
BACKGROUND: SYNERGY, a bioabsorbable polymer-based, everolimus-eluting stent (BP-DES), recently received regulatory approval in the USA for use in percutaneous coronary interventions. Yet, information on the safety of BP-DES in routine clinical practice is limited. Our aim was to compare the safety of the recently approved BP-DES with current durable polymer drug-eluting stents (DP-DES) by analyzing adverse events, namely, stent thrombosis (ST), reported to the Manufacturer and User Facility Device Experience (MAUDE) database...
November 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28712077/insecticidal-effect-and-impact-of-fitness-of-three-diatomaceous-earths-on-different-maize-hybrids-for-the-eco-friendly-control-of-the-invasive-stored-product-pest-prostephanus-truncatus-horn
#16
Nickolas G Kavallieratos, Christos G Athanassiou, Gerassimos G Peteinatos, Maria C Boukouvala, Giovanni Benelli
Diatomaceous earths (DEs) are able to successfully protect grain commodities from noxious stored-product insect and mite infestations; however, their effectiveness may be moderated by the grain hybrid or variety they are applied to. There is a gap of information on the comparison of the efficacy of different DEs when are applied on different maize hybrids against Prostephanus truncatus (Horn). Therefore, here we tested three commercially available DEs (DEA-P at 75 and 150 ppm, Protect-It at 500 ppm, and PyriSec at 500 ppm) on five different maize hybrids (Calaria, Doxa, Rio Grande, Sisco, and Studio) for the control of P...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28709042/perinatal-exposure-of-pregnant-rats-to-cypermethrin-delays-testicular-descent-impairs-fertility-in-f1-male-progeny-leading-to-developmental-defects-in-f2-generation
#17
Dipty Singh, Sharad Bhagat, Paula Raijiwala, Vikas Dighe, Geeta Vanage
Cypermethrin (CYP) is a widely used synthetic pyrethroid insecticide and regarded as a potential endocrine disruptor. CYP exposure may pose a great risk to human health including adverse effect on their reproductive functions. This study aimed to delineate the effects of perinatal exposure of rats to CYP on the sexual maturation and fertility of F1 male progeny. Pregnant rats (F0) were gavaged daily with CYP (0, 1, 10, 25 mg/kg BW/day) and Diethylestilbestrol (DES, 10 μg/kg BW/day), as positive control from gestation day 6 to postnatal day 21...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28699575/proposal-to-reclassify-ehrlichia-muris-as-ehrlichia-muris-subsp-muris-subsp-nov-and-description-of-ehrlichia-muris-subsp-eauclairensis-subsp-nov-a-newly-recognized-tick-borne-pathogen-of-humans
#18
Bobbi S Pritt, Michelle E J Allerdice, Lynne M Sloan, Christopher D Paddock, Ulrike G Munderloh, Yasuko Rikihisa, Tomoko Tajima, Susan M Paskewitz, David F Neitzel, Diep K Hoang Johnson, Elizabeth Schiffman, Jeffrey P Davis, Cynthia S Goldsmith, Curtis M Nelson, Sandor E Karpathy
We have previously described a novel taxon of the genus Ehrlichia (type strain WisconsinT), closely related to Ehrlichia muris, that causes human ehrlichiosis among patients with exposures to ticks in the upper midwestern USA. DNA from this bacterium was also detected in Ixodes scapularis and Peromyscus leucopus collected in Minnesota and Wisconsin. To determine the relationship between the E. muris-like agent (EMLA) and other species of the genus Ehrlichia phenotypic, genotypic and epidemiologic comparisons were undertaken, including sequence analysis of eight gene loci (3906 nucleotides) for 39 EMLA DNA samples and the type strain of E...
July 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28689666/incidence-rates-and-risks-of-diethylstilbestrol-related-clear-cell-adenocarcinoma-of-the-vagina-and-cervix-update-after-40-year-follow-up
#19
Dezheng Huo, Diane Anderson, Julie R Palmer, Arthur L Herbst
OBJECTIVE: Women exposed to diethylstilbestrol (DES) in utero are at increased risk for the development of vaginal and cervical clear cell adenocarcinoma (CCA) at younger age. It is unknown if a second peak will occur in later life, the ages when CCA developed spontaneously in the pre-DES era. The complete epidemiologic curve of CCA has not been reported, yet. METHODS: We reviewed 720 cases of CCA from the CCA registry at the University of Chicago through 2014. Incidence rates and cumulative risks for CCA were calculated based on white women born in the U...
September 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28670059/management-of-pelvic-floor-disorder-in-a-diethylstilbestrol-daughter
#20
Christopher P Chung, Suzanne Cao, Grace Wakabayashi, Ernest S Han
Between 1947 and 1971, the synthetic estrogen diethylstilbestrol (DES) was prescribed to pregnant women to prevent spontaneous abortions. Many studies have demonstrated adverse consequences of prenatal DES exposure. This report describes a DES daughter treated for uterine cancer who presented with a foreshortened vagina of 4 cm and stage III pelvic organ prolapse. She underwent successful vaginal native tissue reconstructive surgery with uterosacral colpopexy and anterior and posterior repair to lengthen her vagina and treat her prolapse...
July 2017: Proceedings of the Baylor University Medical Center
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