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DES Exposure

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https://www.readbyqxmd.com/read/29688260/endocrine-disruptor-exposure-during-development-increases-incidence-of-uterine-fibroids-by-altering-dna-repair-in-myometrial-stem-cells
#1
Lauren Prusinski Fernung, Qiwei Yang, Daitoku Sakamuro, Alpana Kumari, Aymara Mas, Ayman Al-Hendy
Despite the major negative impact uterine fibroids (UFs) have on female reproductive health, little is known about early events that initiate development of these tumors. Somatic fibroid-causing mutations in MED12, the most frequent genetic alterations in UFs (up to 85% of tumors), are implicated in transforming normal myometrial stem cells (MSCs) into tumor-forming cells, though the underlying mechanism(s) leading to these mutations remains unknown. It is well-accepted that defective DNA repair increases the risk of acquiring tumor-driving mutations, though defects in DNA repair have not been explored in UF tumorigenesis...
April 24, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29681479/full-pulpotomy-with-biodentine-in-symptomatic-young-permanent-teeth-with-carious-exposure
#2
Nessrin A Taha, Sakhaa Z Abdulkhader
INTRODUCTION: This prospective study evaluated the outcome of Biodentine (Septodont, Saint Maur des Fosses, France) pulpotomy in young permanent teeth with carious exposure. METHODS: Twenty permanent molar teeth in 14 patients with carious pulp exposure were treated with Biodentine pulpotomy. The age of the patients ranged from 9-17 years (12.3 ± 2.7 years). A preoperative pulpal and periapical diagnosis was established. After informed consent, the tooth was anesthetized, isolated via a dental dam, and disinfected with 5% sodium hypochlorite before caries excavation...
April 19, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29666266/dna-methylation-and-transcriptome-aberrations-mediated-by-er%C3%AE-in-mouse-seminal-vesicles-following-developmental-des-exposure
#3
Yin Li, Katherine J Hamilton, Tianyuan Wang, Laurel A Coons, Wendy N Jefferson, Ruifang Li, Yu Wang, Sara A Grimm, J Tyler Ramsey, Liwen Liu, Kevin E Gerrish, Carmen J Williams, Paul A Wade, Kenneth S Korach
Early transient developmental exposure to an endocrine active compound, diethylstilbestrol (DES), a synthetic estrogen, causes late-stage effects in the reproductive tract of adult mice. Estrogen receptor alpha (ERα) plays a role in mediating these developmental effects. However, the developmental mechanism is not well known in male tissues. Here, we present genome-wide transcriptome and DNA methylation profiling of the seminal vesicles (SVs) during normal development and after DES exposure. ERα mediates aberrations of the mRNA transcriptome in SVs of adult mice following neonatal DES exposure...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29658110/prenatal-diethylstilbestrol-des-exposure-and-mammographic-density
#4
William C Strohsnitter, Kimberly A Bertrand, Rebecca Troisi, Christopher G Scott, Andrea L Cheville, Robert N Hoover, Julie R Palmer, Celine M Vachon
In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort of DES-exposed and unexposed women was assembled at the Mayo Clinic in 1975, and followed through 2012 as part of the National Cancer Institute's DES Follow-up Study. Mammographic density from 3,637 mammograms for 332 (222 DES-exposed, 110 unexposed) women in this cohort screened at the Mayo Clinic, Rochester between 1996 and 2015 were determined clinically using the Breast Imaging Reporting and Data System (BI-RADS)...
April 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29648668/widespread-enhancer-activation-via-er%C3%AE-mediates-estrogen-response-in-vivo-during-uterine-development
#5
Wendy N Jefferson, H Karimi Kinyamu, Tianyuan Wang, Adam X Miranda, Elizabeth Padilla-Banks, Alisa A Suen, Carmen J Williams
Little is known regarding how steroid hormone exposures impact the epigenetic landscape in a living organism. Here, we took a global approach to understanding how exposure to the estrogenic chemical, diethylstilbestrol (DES), affects the neonatal mouse uterine epigenome. Integration of RNA- and ChIP-sequencing data demonstrated that ∼80% of DES-altered genes had higher H3K4me1/H3K27ac signal in close proximity. Active enhancers, of which ∼3% were super-enhancers, had a high density of estrogen receptor alpha (ERα) binding sites and were correlated with alterations in nearby gene expression...
April 10, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29628641/effect-of-surface-protection-on-the-permeability-of-eroded-dentin
#6
Vivian Leite Martins, Rodrigo Vitoria da Costa Ramos, Max José Pimenta Lima, Roberto Paulo Correia de Araújo, Andrea Nóbrega Cavalcanti
Context: Eroded dentin might present the opening of dentinal tubules, increasing permeability, and consequently dentinal hypersensitivity. Aims: This study evaluated the permeability of dentin surfaces exposed to different levels of erosion and methods of surface protection. Materials and Methods: Dentine samples (3 mm × 3 mm × 1 mm) were prepared from bovine incisors ( n = 90) and divided into three groups according to the method of controlling erosive challenge: Negative control, topical fluoride application, and glass ionomer sealant...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29609831/birth-defects-in-children-of-men-exposed-in-utero-to-diethylstilbestrol-des
#7
Michel Tournaire, Emmanuel Devouche, Sylvie Epelboin, Anne Cabau, Annabel Dunbavand, Anne Levadou
OBJECTIVE: Prenatal exposure to diethylstilbestrol (DES) is associated with adverse effects, including genital anomalies and cancers in men and women. Animal studies showed birth defects and tumors in the offspring of mice prenatally exposed to DES. In humans, birth defects, such as hypospadias were observed in children of prenatally exposed women. The aim of this research was to assess the birth defects in children of prenatally exposed men. METHODS: In a retrospective study conceived by a patients' association (Réseau DES France), the reports of men prenatally exposed to DES on adverse health effects in their children were compared with those of unexposed controls and general population...
March 3, 2018: Thérapie
https://www.readbyqxmd.com/read/29609105/health-risk-assessment-of-dermal-exposure-to-chlorpyrifos-among-applicators-on-rice-farms-in-ghana
#8
Albert Atabila, Dung Tri Phung, Jonathan N Hogarh, Ross Sadler, Des Connell, Cordia Chu
Generally, there is limited information on pesticide absorbed dose levels and health risk attributable to the dermal route of exposure among applicators. The objective of this study was to evaluate the absorbed dose levels and consequent health risk from dermal exposure to chlorpyrifos among applicators on rice farms in Ghana. The whole-body dosimetry technique was used to capture chlorpyrifos residues penetrating the applicators' clothing and reaching their skin, as well as residues reaching uncovered body areas of the applicators...
March 19, 2018: Chemosphere
https://www.readbyqxmd.com/read/29601844/in-memorium-clara-m-szego-1916-2017
#9
Richard J Pietras
Dr. Clara M. Szego passed away recently at the age of 101. She was a pioneer in the study of steroid hormone action, particularly the role of estrogens in target tissues. She was first to report on steroid hormone binding with proteins in the circulation in 1946. This observation led to a Ciba Foundation Award of the Endocrine Society in 1953. Claire then followed the steroid hormone and reported on interactions with membrane-associated and nuclear proteins in target cells of the reproductive tract and breast...
March 27, 2018: Steroids
https://www.readbyqxmd.com/read/29550005/cytotoxicity-of-a-new-calcium-silicate-endodontic-sealer
#10
Triantafyllia Vouzara, Garyfallia Dimosiari, Elisabeth A Koulaouzidou, Nikolaos Economides
INTRODUCTION: Resin sealers with biocompatible and bioactive additives have been used in clinical practice. Recently, a calcium silicate root canal sealer was introduced under the name BioRoot RCS (Septodont, Saint Maur-des-Fossés, France). The aim of this study was to evaluate the effects of BioRoot RCS on cell survival and proliferation of cultured cells in parallel with an epoxy resin sealer with calcium phosphate and calcium oxide and a salicylate resin sealer with mineral trioxide aggregate filler...
March 14, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29443486/effects-on-patients-of-variations-in-the-implementation-of-a-cardiometabolic-risk-intervention-program-in-montr%C3%A3-al
#11
Marie-Ève Beauregard, Sylvie Provost, Raynald Pineault, Dominique Grimard, José Pérez, Michel Fournier
INTRODUCTION: In 2011, the Agence de la santé et des services sociaux de Montréal (ASSSM), in partnership with the region's Centres de santé et de services sociaux (CSSS), coordinated the implementation of a program on cardiometabolic risk based on the Chronic Care Model. The program, intended for patients suffering from diabetes or hypertension, involved a series of individual follow-up appointments, group classes and exercise sessions. Our study assesses the impact on patient health outcomes of variations in the implementation of some aspects of the program among the six CSSSs taking part in the study...
February 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29409055/effectiveness-of-additional-lead-shielding-to-protect-staff-from-scattering-radiation-during-endoscopic-retrograde-cholangiopancreatography-procedures
#12
Yoshiaki Morishima, Koichi Chida, Takayoshi Meguro
Endoscopic retrograde cholangiopancreatography (ERCP) is often complex and involves long fluoroscopic times, with significant radiation exposure to medical staff. We investigated protective effects of an additional attached lead shielding device. The lead shielding device covered with the X-ray tube table (0.125 mm lead equivalent) during ERCP procedures. Fluoroscopy scatter radiation, with or without the lead shielding device, was measured using an acrylic phantom and a radiation survey meter. Measurements (25 points) were made at 50 cm intervals, at both 90 and 150 cm above the floor...
February 2, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29407680/factors-associated-with-successful-vs-unsuccessful-smoking-cessation-data-from-a-nationally-representative-study
#13
Fabienne El-Khoury Lesueur, Camille Bolze, Maria Melchior
INTRODUCTION: A substantial proportion of smokers who attempt to stop smoking relapse in the first months. Yet to date, there is limited understanding of the predictors of smoking attempts and their success. We examine the role of tobacco use characteristics, other substance-related factors, as well as socio-demographic characteristics in relation to successful and unsuccessful smoking cessation. METHODS: DePICT (Description des Perceptions, Images, et Comportements liés au Tabagisme) is a nationally representative sample of adults aged between 18 and 64years residing in metropolitan France, who were interviewed by telephone survey (n=4342)...
February 1, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29397003/outcome-of-full-pulpotomy-using-biodentine-in-adult-patients-with-symptoms-indicative-of-irreversible-pulpitis
#14
N A Taha, S Z Abdelkhader
AIM: To assess the outcome of full pulpotomy using Biodentine in permanent teeth with carious exposures and symptoms indicative of irreversible pulpitis. METHODOLOGY: Sixty-four permanent molar teeth with symptomatic vital pulps in 52 patients aged 19-69 years were included. Preoperative pulpal and periapical diagnosis was established. After informed consent, the tooth was anaesthetized, isolated using rubber dam and disinfected with 5% NaOCl before caries excavation; subsequently, the pulp was amputated to the level of the canal orifices...
February 3, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29340879/diethylstilbestrol-arrested-spermatogenesis-and-somatic-growth-in-the-juveniles-of-yellow-catfish-pelteobagrus-fulvidraco-a-fish-with-sexual-dimorphic-growth
#15
Zhi-Hao Liu, Qi-Liang Chen, Qiang Chen, Fang Li, Ying-Wen Li
In fish, spermatogenesis and somatic growth are mainly regulated by hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-somatic (HPS) axes, respectively. Xenoestrogens have been reported to impair spermatogenesis in some fishes, and arrest somatic growth in some others, whereas, whether xenoestrogens are capable of disrupting spermatogenesis and somatic growth simultaneously in fish that exhibits sexual dimorphic growth is little known, and the underlying mechanisms remain poorly understood. In this study, male juveniles of yellow catfish (Pelteobagrus fulvidraco), which exhibits a sexual dimorphic growth that favors males, were exposed to diethylstilbestrol (DES) for 28 days...
January 16, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29326091/erratum-regulation-of-chromatin-assembly-and-cell-transformation-by-formaldehyde-exposure-in-human-cells
#16
Danqi Chen, Lei Fang, Shenglin Mei, Hongjie Li, Xia Xu, Thomas L Des Marais, Kun Lu, X Shirley Liu, Chunyuan Jin
[This corrects the article DOI: 10.1289/EHP1275.].
January 3, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29294725/association-of-domestic-violence-against-women-with-sociodemographic-factors-clinical-features-and-dissociative-symptoms-in-patients-who-receive-services-from-psychiatric-outpatient-units-in-turkey
#17
Zeynep Kotan, Vahap Ozan Kotan, Hayriye Dilek Yalvaç, Sibel Demir
Domestic violence (DV) against women is a serious problem with its negative effects on all family members and the society. Women exposed to DV not only have physical but also psychological damage. This study investigates prevalence of DV and its relations with some descriptive and clinical features in a psychiatric outpatient population in Turkey. A total of 277 female outpatients were included in the study. After a semistructured clinical interview, they were assessed by sociodemographic data form, DV questionnaire, Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Dissociative Experiences Scale (DES), and Somatoform Dissociation Questionnaire (SDQ)...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29275294/effects-of-2-3-bis-4-hydroxyphenyl-propionitrile-on-induction-of-polyovular-follicles-in-the-mouse-ovary
#18
Tomomi Sato, Hannah Kim, Hanako Kakuta, Taisen Iguchi
BACKGROUND/AIM: Neonatal diethylstilbestrol (DES) treatment induces polyovular follicles (PFs), which contain more than two oocytes in a follicle, through estrogen receptor (ER) β, not ERα. 2,3-Bis(4-hydroxyphenyl)-propionitrile (DPN) is a specific ERβ agonist; the effects of neonatal DPN exposure on PF induction and gene expression in the mouse ovary were examined. MATERIALS AND METHODS: Histological analysis and real-time reverse transcription-polymerase chain reaction were performed...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29219636/physiological-effects-of-brominated-flame-retardants-on-nc-nga-mice
#19
Michitaka Tanaka, Ken-Ichiro Inoue, Akinori Shimada, Hirohisa Takano
PURPOSE: Brominated flame retardants (BFRs) are used as an additive or reactive components in various materials. Regarding their health concerns, their immunotoxicity have not been clarified yet. MATERIALS AND METHODS: In the current study, we examined the effects of systemic exposure to two types of BFRs, DE71 and DE79, on pathophysiologic traits of murine atopic dermatitis (AD). Male NC/Nga mice were repeatedly injected intraperitoneally with DE71 and DE79 and/or mite allergen (Dermatophagoides pteronyssinus: Dp) into their right ears...
February 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29216539/influence-of-extracellular-environment-on-the-motility-and-structural-properties-of-spermatozoa-collected-from-hormonally-stimulated-panamanian-golden-frog-atelopus-zeteki
#20
Gina Della Togna, Brian Gratwicke, Matthew Evans, Lauren Augustine, Han Chia, Ed Bronikowski, James B Murphy, Pierre Comizzoli
A better understanding of the factors influencing the biology of amphibian spermatozoa after release from the testis is a prerequisite to the development of sperm preservation methods. The objective of the study was to determine the effect of extracellular conditions (exposure to water and different temperatures) over time on the sperm motility and structural properties (including morphology and DNA integrity) collected from hormonally stimulated Atelopus zeteki. Following intraperitoneal injection of gonadotropin-releasing hormone agonist (des-Gly10 , D-Ala6 , Pro-NHEt9 GnRH; 4 μg/g of body weight), human chorionic gonadotropin (hCG, 10 IU/gbw), or Amphiplex™ (0...
March 1, 2018: Theriogenology
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