keyword
https://read.qxmd.com/read/38273649/ror1-expression-in-mature-b-lymphoid-neoplasms-by-flow-cytometry
#21
JOURNAL ARTICLE
Flávia Arandas de Sousa, Nádila Magalhães Millan, Rodolfo Patussi Correia, Andressa da Costa Vaz, Daniela Schimidell, Priscila Carmona Miyamoto, Marilia Sandoval Passaro, Bruna Garcia Nogueira, Elizabeth Xisto Souto, Nydia Strachman Bacal, Laiz Camerão Bento
Immunophenotyping by flow cytometry is an integral part of the diagnosis and classification of leukemias/lymphomas. The expression of ROR1 associated with chronic B lymphocytic leukemia (CLL) is well described in the literature, both in its diagnosis and in the follow-up of minimal residual disease (MRD) research, however, there are few studies regarding the expression pattern of ROR1 in other subtypes of mature B lymphoid neoplasms. With the aim of evaluating the expression of ROR1 and associating it with the expression of other important markers for the differentiation of mature B lymphoid neoplasms (MBLN), 767 samples of cases that entered our laboratory for immunophenotyping with clinical suspicion of MBLN were studied...
January 2024: Cytometry. Part B, Clinical Cytometry
https://read.qxmd.com/read/38269572/essential-thrombocythemia-2024-update-on-diagnosis-risk-stratification-and-management
#22
JOURNAL ARTICLE
Ayalew Tefferi, Alessandro Maria Vannucchi, Tiziano Barbui
OVERVIEW: Essential thrombocythemia is a Janus kinase 2 (JAK2) mutation-prevalent myeloproliferative neoplasm characterized by clonal thrombocytosis; clinical course is often indolent but might be interrupted by thrombotic or hemorrhagic complications, microcirculatory symptoms (e.g., headaches, lightheadedness, and acral paresthesias), and, less frequently, by disease transformation into myelofibrosis (MF) or acute myeloid leukemia. DIAGNOSIS: In addition to thrombocytosis (platelets ≥450 × 109 /L), formal diagnosis requires the exclusion of other myeloid neoplasms, including prefibrotic MF, polycythemia vera, chronic myeloid leukemia, and myelodysplastic syndromes with ring sideroblasts and thrombocytosis...
January 25, 2024: American Journal of Hematology
https://read.qxmd.com/read/38255996/expression-pattern-and-prognostic-significance-of-the-long-non-coding-rna-metastasis-associated-lung-adenocarcinoma-transcript-1-in-chronic-lymphocytic-leukemia
#23
JOURNAL ARTICLE
Kristina Tomic Vujovic, Milena Ugrin, Natasa Tosic, Vojin Vukovic, Irena Marjanovic, Tatjana Kostic, Sanja Stankovic, Vladimir Otasevic, Sofija Sarac, Darko Antic, Sonja Pavlovic, Teodora Karan-Djurasevic
Dysregulated expression of the long non-coding RNA MALAT1 has been implicated in the pathogenesis and progression of a variety of cancers, including hematological malignancies, but it has been poorly investigated in chronic lymphocytic leukemia (CLL). In this study, the expression of MALAT1 was measured using a quantitative reverse-transcriptase polymerase chain reaction in the peripheral blood mononuclear cells of 114 unselected, newly diagnosed CLL patients in order to analyze its association with clinical, laboratory, and molecular patients' characteristics at diagnosis, as well as its prognostic relevance...
January 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38241957/leukemic-pulmonary-infiltrates-in-chronic-lymphocytic-leukemia-clinical-and-imaging-features
#24
JOURNAL ARTICLE
Vasilios Tzilas, Thomas E Hartman, Jay H Ryu
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries. Although various patterns of lung involvement with CLL have been reported, data on clinicoradiologic presentation are sparse. METHODS: A computer-assisted search was conducted to identify patients encountered at Mayo Clinic from 1998 to 2022 and had leukemic pulmonary infiltrates (LPI) with CLL demonstrated on lung biopsy. Medical records and chest imaging studies were reviewed to identify clinical and radiologic features...
January 18, 2024: Respiratory Investigation
https://read.qxmd.com/read/38239546/corneal-copper-deposition-secondary-to-monoclonal-gammopathy-in-a-patient-with-chronic-lymphocytic-leukemia-a-case-report
#25
Koichiro Shinji, Tai-Ichiro Chikama, Taka-Aki Moriguchi, Atsuhiko Fukuto, Yoshiaki Kiuchi
Hypercupremia-induced corneal copper deposition secondary to monoclonal gammopathy is rare and shows a characteristic corneal opacity quite different from other causes of hypercupremia, such as Wilson's disease. This report describes a case of corneal copper deposition in a patient with monoclonal gammopathy associated with chronic lymphocytic leukemia. An 84-year-old man with slowly progressive corneal opacity was referred to our hospital. The corneal opacity was present at least five years ago. The patient's best-corrected visual acuity was 20/25 OU (in both eyes) at the initial visit to our hospital...
December 2023: Curēus
https://read.qxmd.com/read/38236391/prediction-of-severe-infections-in-chronic-lymphocytic-leukemia-a-simple-risk-score-to-stratify-patients-at-diagnosis
#26
JOURNAL ARTICLE
Roberta Murru, Andrea Galitzia, Luca Barabino, Roberta Presicci, Giorgio La Nasa, Giovanni Caocci
Chronic Lymphocytic Leukemia (CLL) is well-known for increasing susceptibility to infections. Factors such as immune dysregulation, IGHV status, hypogammaglobulinemia, and patient comorbidity and treatment, contribute to higher infection rates and mortality. However, the impact of hypogammaglobulinemia on infection rates is controversial. We aimed to identify clinical and biological parameters linked to the risk of severe infectious events. Additionally, we set up a straightforward risk infection score to stratify CLL patients at diagnosis, thereby enabling the development of suitable infection prevention strategies...
January 18, 2024: Annals of Hematology
https://read.qxmd.com/read/38214879/prolymphocytic-leukaemia-an-update-on-biology-and-treatment
#27
REVIEW
Dima El-Sharkawi, Claire Dearden
PURPOSE OF REVIEW: This review summarises the recent advances in knowledge regarding the biology and treatment of prolymphocytic leukaemias. RECENT FINDINGS: Both B-PLL and T-PLL are genetically complex, and the molecular landscape of these diseases has been well characterised recently. Diagnostic criteria for T-PLL have been refined with the publication of the first international consensus criteria, whereas the diagnosis of B-PLL has been thrown into question by the most recent WHO classification...
January 2, 2024: Current Oncology Reports
https://read.qxmd.com/read/38196816/unusual-presentation-of-b-cell-chronic-lymphocytic-leukemia-accompanied-by-pure-red-cell-aplasia-case-report
#28
Jane Atallah, Yarub Al Alousi, Nehemias Guevara, Iurii Statnii, Sameh Nassar, Ivette Vigoda
INTRODUCTION: Pure red cell aplasia (PRCA) is a rare bone marrow failure characterized by normocytic anemia and severe reticulocytopenia. CASE PRESENTATION: We describe the case of a 38-year-old female who presented with severe anemia. Further investigation revealed the etiology of anemia to be PRCA. She was subsequently diagnosed with chronic lymphocytic leukemia (CLL) B-cell type on bone marrow biopsy. The patient refused blood transfusion support. She failed to improve and expired despite treatment with rituximab and steroids...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38188906/severe-hyperglycemia-due-to-protein-kinase-inhibitor-therapy-in-a-patient-with-poorly-controlled-diabetes-mellitus
#29
Isabel Sontag, Laura Bergmann, Henning Ernst Adamek
The efficacy and safety of zanubrutinib, a highly selective next-generation Bruton's tyrosine kinase (BTK) inhibitor, in chronic lymphocytic leukemia and lymphoplasmocytoides immunocytoma seems favorable. Adverse events comprise neutropenia, thrombocytopenia, infection, anemia, and atrial fibrillation. This report describes a 75-year-old man suffering from polydipsia, polyuria, and blurred vision for 10 days. He was diagnosed with lymphoplasmocytoides immunocytoma in 2003. After various therapies, he was started on zanubrutinib in October 2022...
January 2024: JCEM Case Rep
https://read.qxmd.com/read/38188472/cryocrystalglobulinemia-leading-to-multi-organ-failure-in-chronic-lymphocytic-leukemia-achieving-complete-renal-recovery
#30
Ashley Dunton, Shivi Jain
Cryocrystalglobulinemia (CCG) is a rare and fatal subset of type I cryoglobulinemia that is classically associated with an underlying monoclonal gammopathy. Cryocrystalglobulins are created when immunoglobulins self-assemble into extracellular crystal arrays, which often leads to severe systemic hypoperfusion and occlusive vasculopathy that culminates in multi-organ failure. Most commonly, the resultant ischemia manifests as cutaneous lesions and renal insufficiency, which can progress to fulminant kidney failure requiring renal replacement therapy...
December 2023: Journal of Hematology (Brossard, Quebec)
https://read.qxmd.com/read/38186023/immunophenotype-of-leukemic-cells-in-chronic-lymphocytic-leukemia-patients-with-notch1-and-sf3b1-gene-mutations
#31
JOURNAL ARTICLE
N Golyarnik, І Абраменко, G Movchan, Z Martina, I Dyagil, A Chumak, D Bazyka
BACKGROUND: The typical chronic lymphocytic leukemia (CLL) immunophenotype is vital for diagnosis, but the expression of some antigens varies and has prognostic value. There are data that reduced CD20 expression is associated with NOTCH1 and SF3B1 gene mutations. AIM: To determine a high-risk group of CLL patients for prediction of unfavorable NOTCH1 and SF3B1 gene mutations based on immunophenotyping of leukemic cells. MATERIALS AND METHODS: Flow cytometric and molecular-genetic analysis (mutations of NOTCH1, SF3B1, and TP53 genes using the polymerase chain reaction followed by direct sequencing) was performed in a group of 86 previously untreated CLL patients...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38185521/-clinical-and-molecular-biological-characterization-of-patients-with-accelerated-chronic-lymphocytic-leukemia
#32
JOURNAL ARTICLE
Z Y Zhou, L M J Dai, Y Q Sha, T L Qiu, S C Qin, Y Miao, Y Xia, W Wu, H N Tang, W Xu, J Y Li, H Y Zhu
Objective: To investigate the clinical and molecular biological characteristics of patients with accelerated chronic lymphocytic leukemia (aCLL) . Methods: From January 2020 to October 2022, the data of 13 patients diagnosed with aCLL at The First Affiliated Hospital of Nanjing Medical University were retrospectively analyzed to explore the clinical and molecular biological characteristics of aCLL. Results: The median age of the patients was 54 (35-72) years. Prior to aCLL, five patients received no treatment for CLL/small lymphocytic lymphoma (SLL), while the other patients received treatment, predominantly with BTK inhibitors...
November 14, 2023: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38179708/identifying-cll-patients-at-high-risk-of-atrial-fibrillation-on-treatment-using-machine-learning
#33
JOURNAL ARTICLE
Mehdi Parviz, Rudi Agius, Emelie Curovic Rotbain, Noomi Vainer, Kathrine Aarup, Carsten U Niemann
An increased risk of developing atrial fibrillation (AF) has been observed in patients with chronic lymphocytic leukemia (CLL) who were treated with ibrutinib and other BTK inhibitors. Previous studies have explored the prevalence of AF in CLL and the risk of developing AF at time of diagnosis. However, the interaction between treatment type with other risk factors on risk of developing atrial fibrillation at the time of treatment initiation has not been investigated. This becomes particularly crucial in CLL, as there is often a substantial time gap between diagnosis and treatment, unlike many other cancers...
January 5, 2024: Leukemia & Lymphoma
https://read.qxmd.com/read/38166067/acquired-von-willebrand-s-syndrome-in-a-patient-with-concomitant-chronic-lymphocytic-lymphoma-and-smoldering-multiple-myeloma
#34
JOURNAL ARTICLE
Nirav Haribhakti, Hyun Lee, Matthew Quesenberry, John Reagan
An African-American female in her sixties presented to the hospital with intermittent gum bleeding for the past two years along with severe anemia. This case details the differential and workup that lead to the diagnosis of acquired von Willebrand's syndrome (AvWS). A thorough investigation in the possible etiologies of AvWS revealed that the patient had concomitant chronic lymphocytic lymphoma (CLL) and smoldering multiple myeloma (SMM). Due to the concomitant diagnosis of CLL and SMM, there was a dilemma regarding whether CLL, SMM, or both was driving this patient's AvWS...
January 4, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38163644/intraocular-sarcoid-like-reaction-in-patients-with-chronic-lymphocytic-leukemia
#35
JOURNAL ARTICLE
Ali R Salman, Wendy M Smith, Timothy W Olsen, Lauren A Dalvin
OBJECTIVE: To investigate the frequency and clinical features of intraocular paraneoplastic sarcoid-like reaction (SLR) in patients with chronic lymphocytic leukemia (CLL). METHODS: Retrospective review of patients with CLL from January 1, 1980, to December 31, 2020. Eye examinations were searched for 22 keywords suggestive of SLR, and charts were manually reviewed. RESULTS: Of 4209 unique patients with CLL, 1021 (24%) had at least 1 eye examination on record, and 324 (8%) had 1 or more keyword eye examination findings...
December 29, 2023: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/38158953/-exudative-pericarditis-with-tamponade-after-covid-19-case-report
#36
JOURNAL ARTICLE
L I Dvoretsky, S A Rachina, M G Poltavskaya, D A Andreev, E V Tarykina, N A Plaksina, V V Minaev, A V Terekhova
A description of a COVID-19 patient with the development of exudative pericarditis complicated by cardiac tamponade is provid. A peculiarity of this case is the presence of an underlying disease in the patient (chronic lymphocytic leukemia), which was in remission for 1.5 years after chemotherapy. Another feature of the patient was the relatively small area of lung damage and the hemorrhagic nature of the pericardial effusion, which persisted for a long time. The insignificant activity of inflammatory markers was noteworthy...
December 22, 2023: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/38158353/quality-and-quantity-of-nucleic-acids-extracted-from-formalin-fixed-paraffin-embedded-lymphoma-biopsies-from-nigerian-archived-biopsy
#37
JOURNAL ARTICLE
I C Uzoma, I A Taiwo, N I Ugwu, M A Durosinmi, O Akinloye
BACKGROUND: Integrity of nucleic acids derived from archived formalin-fixed paraffin-embedded (FFPE) cancer specimens affects diagnosis, prognosis, and therapy. Several factors affect the quality and quantity of extracted nucleic acids and one of such factors is storage period. AIM: We investigated the impact of storage duration on the quality and quantity of nucleic acids extracted from archived FFPE lymphoma biopsies in Nigeria. MATERIALS AND METHODS: A total of 53 FFPE biopsies diagnosed as lymphoma stored over several years (2008-2019) were analyzed...
December 1, 2023: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38155128/the-course-of-chronic-lymphocytic-leukemia-after-sars-cov-2-virus-infection
#38
JOURNAL ARTICLE
I S Dyagil, I V Abramenko, Z V Martina, N A Golyarnic, V V Brychenko, A V Movchan, A A Chumak, D A Bazyka
Objective - to investigate the course of B-cell chronic lymphocytic leukemia (CLL) in patients after SARS-CoV-2 virus infection taking into account anamnestic exposure to the ionizing radiation (IR).Methods. The study was performed in a group of 51 CLL patients who were admitted to the Department of Radiation hematology of the National Research Center for Radiation Medicine of NAMS of Ukraine, Kyiv, from January 2020 (the beginning of SARS-CoV-2 epidemic) to August 2023. The group included 19 (37.3 %) clean-up workers of the Chornobyl NPP accident, 15 (29...
December 2023: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://read.qxmd.com/read/38150112/investigation-of-fatty-acid-metabolism-in-chronic-lymphocytic-leukemia-to-guide-clinical-outcome-and-therapy
#39
JOURNAL ARTICLE
Bihui Pan, Zhangdi Xu, Kaixin Du, Rui Gao, Jiale Zhang, Hua Yin, Haorui Shen, Jinhua Liang, Yue Li, Li Wang, Jianyong Li, Wei Xu, Jiazhu Wu
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the West. With CLL's heterogeneity, some people still develop disease refractory and relapse despite advances in treatment. Thus, early diagnosis and treatment of high-risk CLL patients is critical. Fatty acid (FA) metabolism contributes to tumorigenesis, progression, and therapy resistance through enhanced lipid synthesis, storage, and catabolism. In this study, we aimed to construct a prognostic model to improve the risk stratification of CLL and reveal the link between FA metabolism and CLL...
December 27, 2023: Annals of Hematology
https://read.qxmd.com/read/38148012/treatment-patterns-in-patients-with-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-post-covalent-bruton-tyrosine-kinase-inhibitor-treatment-a-japanese-claims-database-study
#40
JOURNAL ARTICLE
Dai Maruyama, Chaochen Wang, Yoshinori Tanizawa, Zhihong Cai, Yujing Huang, Masaomi Tajimi, Shigeru Kusumoto
Standard treatment has not been established for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) after discontinuation of covalent Bruton tyrosine kinase inhibitor (cBTKi) therapy. This retrospective, administrative database (Medical Data Vision) study described the patient characteristics, treatment patterns, and factors associated with receiving post-first-cBTKi treatment in Japanese patients with CLL/SLL. Patients aged ≥18 years with confirmed CLL/SLL diagnosis and treated with anti-neoplastic drugs indicated for CLL/SLL between March 2013 and February 2022 were included...
2023: Journal of Clinical and Experimental Hematopathology: JCEH
keyword
keyword
88632
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.