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https://www.readbyqxmd.com/read/28651327/alpha-klotho-and-fibroblast-growth-factor-23-among-alcoholics
#1
Geraldine Quintero-Platt, Emilio González-Reimers, Melchor Rodríguez-Gaspar, Candelaria Martín-González, Onán Pérez-Hernández, Lucía Romero-Acevedo, Elisa Espelosín-Ortega, María José de la Vega-Prieto, Francisco Santolaria-Fernández
Aims: Alcoholism may be a cardiovascular risk factor. Osteocyte derived molecules such as fibroblast growth factor 23 (FGF-23) and soluble α Klotho have recently been associated with cardiovascular disease, but their role in alcoholics is unknown. We here analyze the behavior of FGF23 and α Klotho in alcoholics. Methods: Ninety-seven alcoholic patients were assessed for liver function, presence of hypertension, diabetes, atrial fibrillation, left ventricular hypertrophy (LVH), vascular calcifications (assessed by chest X-ray) and nutritional status (lean and fat mass measured by densitometry)...
June 23, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28651187/association-of-ectopic-fat-with-abdominal-aorto-illiac-and-coronary-artery-calcification-in-african-ancestry-men
#2
Allison L Kuipers, Joseph M Zmuda, J Jeffrey Carr, James G Terry, Sangeeta Nair, Ryan Cvejkus, Clareann H Bunker, Alan L Patrick, Christina L Wassel, Iva Miljkovic
BACKGROUND AND AIMS: There is strong evidence that fat accumulating in non-adipose sites, "ectopic fat", is associated with cardiovascular disease (CVD), including vascular calcification. Most previous studies of this association have assessed only a single ectopic fat depot. Therefore, our aim was to assess the association of total, regional, and ectopic fat with abdominal aorto-illiac calcification (AAC) and coronary artery calcification (CAC) in 798 African ancestry men. METHODS: Participants (mean age 62) were from the Tobago Bone Health Study cohort...
June 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28651186/circulating-malondialdehyde-modified-low-density-lipoprotein-mda-ldl-as-a-novel-predictor-of-clinical-outcome-after-endovascular-therapy-in-patients-with-peripheral-artery-disease-pad
#3
Taka-Aki Takamura, Taketsugu Tsuchiya, Minako Oda, Makoto Watanabe, Ryuhei Saito, Ryoko Sato-Ishida, Hironobu Akao, Yasuyuki Kawai, Michihiko Kitayama, Kouji Kajinami
BACKGROUND AND AIMS: Despite advances in the treatment of peripheral artery disease (PAD), cardiovascular events and death rates remain high. This study aimed at identifying markers of outcome in patients with PAD undergoing endovascular therapy (EVT). METHODS: Consecutive patients undergoing EVT were recruited. Markers of oxidative stress (malondialdehyde-modified low-density lipoprotein [MDA-LDL]), inflammation (IL-6; high-sensitivity C-reactive protein [hsCRP]) and fibrinolysis (D-dimer) were measured pre-EVT and at post-EVT time-points to 36 h...
June 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28650667/gender-specific-association-between-fgfr4-gly388arg-gene-variants-and-hypertension
#4
Nasser M Al-Daghri, Abdul Khader Mohammed, Omar S Al-Attas, Hossam M Draz, Majed S Alokail
AIMS: Variations in fibroblast growth factor (FGF) levels have been associated with alterations in blood pressure. FGFs mediate their function through binding to their FGF receptor (FGFR). FGFR4 Gly388Arg polymorphism is associated with cancer and cardiovascular diseases, but its association with hypertension is unclear. Here, we aimed to investigate the association between FGFR4 Gly388Arg polymorphism and hypertension. MATERIALS AND METHODS: Three hundred Saudi individuals (150 normotensive controls and 150 hypertensive subjects) were genotyped for FGFR4 Gly388Arg (G/A) polymorphism using polymerase chain reaction-restriction fragment length polymorphism method...
June 26, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28650207/epicardial-pericardial-and-total-cardiac-fat-and-cardiovascular-disease-in-type-2-diabetic-patients-with-elevated-urinary-albumin-excretion-rate
#5
Regitse H Christensen, Bernt J von Scholten, Christian S Hansen, Sarah E Heywood, Jaya B Rosenmeier, Ulrik B Andersen, Peter Hovind, Henrik Reinhard, Hans-Henrik Parving, Bente K Pedersen, Marit E Jørgensen, Peter K Jacobsen, Peter Rossing
Background We evaluated the association of cardiac adipose tissue including epicardial adipose tissue and pericardial adipose tissue with incident cardiovascular disease and mortality, coronary artery calcium, carotid intima media thickness and inflammatory markers. Design A prospective study of 200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER). Methods Cardiac adipose tissue was measured from baseline echocardiography. The composite endpoint comprised incident cardiovascular disease and all-cause mortality...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28649567/effect-of-dark-chocolate-extracts-on-phorbol-12-myristate-13-acetate-induced-oxidative-burst-in-leukocytes-isolated-by-normo-weight-and-overweight-obese-subjects
#6
Francesca Ioannone, Giampiero Sacchetti, Mauro Serafini
Oxidative and inflammatory stress represents a major risk factor for cardiovascular disease (CVD) in overweight and obese subjects. Between the different plant foods, chocolate has been shown to decrease CVD risk due to its antioxidant and anti-inflammatory properties. However, as we recently showed in epidemiological studies, meta-analyses, and human trials, dietary antioxidants resulted more effective in subjects characterized by an ongoing oxidative stress, than in healthy people. Aim of this work was to investigate the effect of different concentrations of chocolate phenolic extract (CPE) on in vitro free radical production, stimulated by phorbol 12-myristate 13-acetate (PMA), in leukocytes extracted from blood of normo-weight and overweight/obese subjects...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28649465/dietary-and-cardio-metabolic-risk-factors-in-patients-with-obstructive-sleep-apnea-cross-sectional-study
#7
Marta Stelmach-Mardas, Marcin Mardas, Khalid Iqbal, Magdalena Kostrzewska, Tomasz Piorunek
BACKGROUND: Little is known about the role of dietary intake in obstructive sleep apnea (OSA), which could prove important in improving clinical outcomes for people with obesity and/or cardiovascular disease within these populations. Reduction in energy intake typically results in weight loss, markedly improving metabolic parameters and ameliorating OSA severity. The aim of this study was to evaluate the association of dietary and cardio-metabolic risk factors with OSA severity. METHODS: This was a cross-sectional study...
2017: PeerJ
https://www.readbyqxmd.com/read/28648967/glans-necrosis-following-penile-prosthesis-implantation-prevention-and-treatment-suggestions
#8
Steven K Wilson, Cesar Mora-Estaves, Paulo Egydio, David Ralph, Mohamad Habous, Christopher Love, Ahmad Shamsodini, Robert Valenzuela, Faysal A Yafi
OBJECTIVE: To examine possible etiology and treatment outcomes in 21 patients with glans necrosis following penile prosthesis implantation. METHODS: Glans necrosis typically presented with a dusky glans on first post-operative day following prosthesis implantation. RESULTS: The blood supply to the glans penis consists of the dorsal arteries and the terminal branches of the spongiosal arteries. Using this cohort, we compiled pre-operative comorbidities and adjunctive surgical maneuvers that might compromise glans vascularity leading to glans necrosis...
June 22, 2017: Urology
https://www.readbyqxmd.com/read/28648423/evaluation-of-gamma-glutamyl-transferase-as-a-marker-of-cardiovascular-risk-in-200-angiographically-proven-coronary-artery-disease-patients
#9
Vani Bharani, V Ramesh, Ram Nawal Rao, Satyendra Tewari
Gamma glutamyl transferase (GGT) is emerging as a promising marker for assessing cardiovascular risk. GGT predicts cardiovascular mortality in the population and is positively associated with traditional risk factors for coronary artery disease (CAD). This study was undertaken on 200 north Indian CAD patients diagnosed with coronary angiography to study relation of GGT with risk factors for CAD and severity of CAD. GGT values ranged from 5 to 69U/L and were divided in 4 quartiles. GGT was positively associated with triglyceride (p=0...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28648098/the-effect-of-perceived-control-on-self-reported-cardiovascular-disease-incidence-across-adulthood-and-old-age
#10
Frank J Infurna, Axel Mayer, Kaarin J Anstey
OBJECTIVE: To examine whether rates of change in perceived control are predictive of cardiovascular disease (CVD) incidence across adulthood and old age. DESIGN: We used the PATH Through Life Project (n = 7103, M = 40, SD = 16; 52% women), a longitudinal panel survey that encompasses three cohorts at Time 1, ages 20-24, 40-44 and 60-64, who have been assessed three times at four-year intervals. METHOD: We examined whether rates of change in perceived control were associated with CVD incidence over 8 years of time, over and above that of baseline levels of perceived control and known risk factors for CVD...
June 26, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28647711/down-syndrome-and-moyamoya-disease-unusual-cause-of-stroke
#11
Carlos Tavares Bello, Catarina Barreiros, Inês Gil, Carlos Vasconcelos
Down syndrome is a frequent clinical entity, being considered one of the most frequent chromosomal aberrations. It is characterised by a typical clinical phenotype and is associated with a heterogeneous group of organ and system-specific abnormalities. The cardiovascular system is commonly affected and if so, it may be associated with an increased morbidity and mortality. Cerebrovascular events in patients with Down syndrome are multifactorial, being possibly related to congenital heart disease, vascular malformations and traditional cardiovascular risk factors...
June 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28647686/increased-risk-of-acute-arterial-events-in-young-patients-and-severely-active-ibd-a-nationwide-french-cohort-study
#12
Julien Kirchgesner, Laurent Beaugerie, Fabrice Carrat, Nynne Nyboe Andersen, Tine Jess, Michaël Schwarzinger
OBJECTIVE: Magnitude and independent drivers of the risk of acute arterial events in IBD are still unclear. We addressed this question in patients with IBD compared with the general population at a nationwide level. DESIGN: Using the French National Hospital Discharge Database from 2008 to 2013, all patients aged 15 years or older and diagnosed with IBD were identified and followed up until 31 December 2013. The rates of incident acute arterial events were calculated and the impact of time with active disease (period around hospitalisation for IBD flare or IBD-related surgery) on the risk was assessed by Cox regression adjusted for traditional cardiovascular risk factors...
June 24, 2017: Gut
https://www.readbyqxmd.com/read/28646716/histopathologic-differences-partially-distinguish-syndromic-aortic-diseases
#13
Kevin M Waters, Lisa M Rooper, Andrew Guajardo, Marc K Halushka
A variety of syndromic diseases such as Marfan syndrome, Loeys-Dietz syndrome, and bicuspid aortic valve with aneurysm along with risk factors of smoking and hypertension result in ascending aortic aneurysms and dissections. Historically, a complicated variety of terms have been used to describe a range of histopathologies that are present in resected specimens. As a result, no consistent patterns of histopathology have been reported. We used the recent Society for Cardiovascular Pathology/Association for European Cardiovascular Pathology consensus statement on nomenclature and diagnostic criteria for noninflammatory aortic disease to blindly evaluate 148 surgically resected specimens...
June 15, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28646427/tanshinone-iia-attenuates-atherosclerosis-in-apolipoprotein-e-knockout-mice-infected-with-porphyromonas-gingivalis
#14
Yan Xuan, Yue Gao, Hao Huang, Xiaoxuan Wang, Yu Cai, Qing Xian Luan
Tanshinone IIA (TSA), a pharmacologically active component isolated from Danshen, may prevent cardiovascular diseases due to its anti-inflammatory, anti-oxidative, and anti-adipogenic effects. Porphyromonas gingivalis, a major periodontal pathogen, may contribute to the progression of atherosclerosis. Here, we studied the effects of TSA on atherosclerosis in ApoE(-/-) mice with P. gingivalis infection. Eight-week-old ApoE(-/-) mice were randomized to (a) phosphate-buffered saline (PBS), (b) P. gingivalis, and (c) P...
June 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28646237/insulin-like-growth-factor-1-in-relation-to-future-hearing-impairment-findings-from-the-english-longitudinal-study-of-ageing
#15
Camille Lassale, G David Batty, Andrew Steptoe, Paola Zaninotto
Insulin-like Growth Factor 1 (IGF-1) is associated with cardiovascular disease, itself a risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for IGF-1 in hearing function. However, the link between IGF-1 and the occurrence of hearing impairment is untested in population-based studies of humans. A total of 4390 participants aged ≥50 y (mean [SD] age 64.2 [8.0] years at baseline, 55% women) from the English Longitudinal Study of Ageing provided serum levels of IGF-1 in 2008 and again in 2012...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645730/the-relation-of-digital-vascular-function-to-cardiovascular-risk-factors-in-african-americans-using-digital-tonometry-the-jackson-heart-study
#16
Eric E McClendon, Solomon K Musani, Tandaw E Samdarshi, Sushant Khaire, Donny Stokes, Naomi M Hamburg, Koby Sheffy, Gary F Mitchell, Herman R Taylor, Emelia J Benjamin, Ervin R Fox
Digital vascular tone and function, as measured by peripheral arterial tonometry (PAT), are associated with cardiovascular risk and events in non-Hispanic whites. There are limited data on relations between PAT and cardiovascular risk in African-Americans. PAT was performed on a subset of Jackson Heart Study participants using a fingertip tonometry device. Resting digital vascular tone was assessed as baseline pulse amplitude. Hyperemic vascular response to 5 minutes of ischemia was expressed as the PAT ratio (hyperemic/baseline amplitude ratio)...
June 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28645467/citreoviridin-induces-triglyceride-accumulation-in-hepatocytes-through-inhibiting-ppar-%C3%AE-in-vivo-and-in-vitro
#17
Chang Feng, Dandan Li, Liping Jiang, Xiaofang Liu, Qiujuan Li, Chengyan Geng, Xiance Sun, Guang Yang, Xiaofeng Yao, Min Chen
Citreoviridin (CIT) is a mycotoxin produced by Penicillum citreonigrum, Aspergillus terreus and Eupenicillium ochrosalmoneum. CIT occurs naturally in moldy rice and corn. CIT is associated with the development of atherosclerosis in the general population. Alteration in hepatic lipid metabolism is a pathogenic factor in atherosclerosis. However the effect and the underlying mechanism of CIT on hepatic lipid metabolism are largely unknown. In this study, we reported that CIT induced triglyceride accumulation in mice liver and human liver HepG2 cells as shown in oil red O staining...
June 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28645284/healthcare-expenditure-on-indigenous-and-non-indigenous-australians-at-high-risk-of-cardiovascular-disease
#18
Blake Angell, Tracey-Lea Laba, Tom Lung, Alex Brown, Sandra Eades, Tim Usherwood, David Peiris, Laurent Billot, Graham Hillis, Ruth Webster, Andrew Tonkin, Christopher Reid, Barbara Molanus, Natasha Rafter, Alan Cass, Anushka Patel, Stephen Jan
BACKGROUND: In spite of bearing a heavier burden of death, disease and disability, there is mixed evidence as to whether Indigenous Australians utilise more or less healthcare services than other Australians given their elevated risk level. This study analyses the Medicare expenditure and its predictors in a cohort of Indigenous and non-Indigenous Australians at high risk of cardiovascular disease. METHODS: The healthcare expenditure of participants of the Kanyini Guidelines Adherence with the Polypill (GAP) pragmatic randomised controlled trial was modelled using linear regression methods...
June 23, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28645072/association-of-the-serum-myeloperoxidase-high-density-lipoprotein-particle-ratio-and-incident-cardiovascular-events-in-a-multi-ethnic-population-observations-from-the-dallas-heart-study
#19
Htet W Khine, John F Teiber, Robert W Haley, Amit Khera, Colby R Ayers, Anand Rohatgi
BACKGROUND AND AIMS: Myeloperoxidase (MPO), a product of systemic inflammation, promotes oxidation of lipoproteins; whereas, high-density lipoprotein (HDL) exerts anti-oxidative effects in part via paraoxonase-1 (PON1). MPO induces dysfunctional HDL particles; however, the interaction of circulating levels of these measures in cardiovascular disease (CVD) has not been studied in humans. We tested whether serum levels of MPO indexed to HDL particle concentration (MPO/HDLp) are associated with increased CVD risk in a large multiethnic population sample, free of CVD at baseline...
June 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28645071/television-viewing-and-risk-of-mortality-exploring-the-biological-plausibility
#20
Mark Hamer, Thomas Yates, Panayotes Demakakos
BACKGROUND AND AIMS: Television (TV) viewing is a major component of leisure sedentary time, and has been consistently associated with cardiovascular disease. We examined the extent to which metabolic biomarkers explain the association between TV viewing and mortality. METHODS: Participants (N = 8,451, aged 64.8 ± 9.9 yrs) were drawn from The English Longitudinal Study of Ageing (ELSA), a national prospective cohort study of community-dwelling men and women living in England...
June 9, 2017: Atherosclerosis
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