Ella Burchill, Cameron James Watson, Jack B Fanshawe, James Brunton Badenoch, Emma Rengasamy, Dory Anthony Ghanem, Constantine Holle, Isabella Conti, Mohammed Ahmed Sadeq, Aman Saini, Abdelilah Lahmar, Ben Cross, Gareth McGuigan, Amar Nandrha, Edward J Kane, Julia Wozniak, Reem Mohamed Farouk Ghorab, Jia Song, Andrew Sommerlad, Andrew Lees, Michael S Zandi, Anthony S David, Glyn Lewis, Ben Carter, Jonathan P Rogers
BACKGROUND: The burden of psychiatric symptoms in Parkinson's disease includes depression, anxiety, apathy, psychosis, and impulse control disorders. However, the relationship between psychiatric comorbidities and subsequent prognosis and neurological outcomes is not yet well understood. In this systematic review and meta-analysis, in individuals with Parkinson's disease, we aimed to characterise the association between specific psychiatric comorbidities and subsequent prognosis and neurological outcomes: cognitive impairment, death, disability, disease progression, falls or fractures and care home admission...
April 2024: The Lancet regional health. Europe