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https://www.readbyqxmd.com/read/28433952/what-chickens-might-tell-us-about-the-mhc-class-ii-system
#1
REVIEW
Aimée Parker, Jim Kaufman
Almost all knowledge about the structure and function of MHC class II molecules outside of mammals comes from work with chickens. Most of the genes implicated in the class II system are present in chickens, so it is likely that the machinery of antigen processing and peptide-loading is similar to mammals. However, there is only one isotype (lineage) of classical class II genes, with one monomorphic DR-like BLA gene and two polymorphic BLB genes, located near one DMA and two DMB genes. The DMB2 and BLB2 genes are widely expressed at high levels, whereas the DMB1 and BLB1 genes are only expressed at highest levels in spleen and intestine, suggesting the possibility of two class II systems in chickens...
April 20, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28432633/synthesis-spectral-properties-and-dft-calculations-of-new-ruthenium-ii-polypyridyl-complexes-dna-binding-affinity-and-in-vitro-cytotoxicity-activity
#2
Rajender Reddy Mallepally, Nagamani Chintakuntla, Venkat Reddy Putta, Nagasuryaprasad K, Ravi Kumar Vuradi, Madhuri P, Satyanarayana Singh S, Ramesh Kumar Chitumalla, Joonkyung Jang, Nagababu Penumaka, Satyanarayana Sirasani
In this paper a novel ligand debip (2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f] [1, 10]phenanthroline) and its Ru(II) polypyridyl complexes [Ru(L)2(debip)](2+), (L = phen (1), bpy (2) and dmb (3)) have been synthesized and characterized by spectroscopic techniques. The DNA binding studies for all these complexes were examined by absorption, emission, quenching studies, viscosity measurements and cyclic voltammetry. The light switching properties of complexes 1-3 have been evaluated. Molecular docking, Density Functional Theory (DFT) and time dependent DFT calculations were performed...
April 22, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28379113/comparison-of-health-parameters-in-normal-cats-fed-a-limited-iodine-prescription-food-vs-a-conventional-diet
#3
Inke Paetau-Robinson, Lynda D Melendez, S Dru Forrester, Laura J Armbrust, Kent R Refsal, Patricia A Burris
Objectives The objective was to compare the effect on thyroid function in healthy, adult cats fed a limited iodine food or conventional diet for 24 months. Methods Cats in the limited iodine group (n = 14) were fed a commercial, dry food containing 0.2 ppm iodine on a dry-matter basis (DMB). Cats in the conventional diet group (n = 12) were fed an identical diet except that the iodine content was 3.2 ppm on a DMB. Both groups were maintained on their respective diets for 24 months. The median age of the cats at baseline was 3...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28377725/gut-microbiota-dependent-metabolite-trimethylamine-n-oxide-contributes-to-cardiac-dysfunction-in-western-diet-induced-obese-mice
#4
Kui Chen, Xiaoqian Zheng, Mingchen Feng, Dongliang Li, Hongqi Zhang
Excessive consumption of diets high in sugars and saturated fat, frequently known as western diet (WD), may lead to obesity and metabolic syndrome. Recent evidence shows that WD-induced obesity impairs cardiac function, but the underlying mechanisms are not fully understood. Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite of specific dietary nutrients, has emerged as a key contributor to cardiovascular disease pathogenesis. We tested the hypothesis that elevated circulating TMAO levels contribute to cardiac dysfunction in WD-induced obesity...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28356347/leukocyte-phosphodiesterase-expression-after-lipopolysaccharide-and-during-sepsis-and-its-relationship-with-hla-dr-expression
#5
Christophe Lelubre, Hayfa Medfai, Israa Akl, Jenneke Leentjens, Matthijs Kox, Peter Pickkers, Alexandre Rousseau, Patrick Biston, Michael Piagnerelli, Michel Vanhaeverbeek, Pierrick Uzureau, Jean-Louis Vincent, Luc Vanhamme, Karim Zouaoui Boudjeltia
Phosphodiesterases (PDEs) may modulate inflammatory pathways, but PDE expression is poorly documented in humans with sepsis. Using quantitative PCR on whole blood leukocytes, we characterized PDE mRNA expression in healthy volunteers (n = 20), healthy volunteers given lipopolysaccharide (LPS; n = 18), and critically ill patients with (n = 20) and without (n = 20) sepsis. PDE4B protein expression was also studied in magnetic-activated cell sorting (MACS)-isolated CD15(+) neutrophils (from 7 healthy volunteers, 5 patients without and 5 with sepsis)...
March 29, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28280812/photo-driven-electron-transfer-from-the-highly-reducing-excited-state-of-naphthalene-diimide-radical-anion-to-a-co2-reduction-catalyst-within-a-molecular-triad
#6
Jose F Martinez, Nathan T La Porte, Catherine M Mauck, Michael R Wasielewski
The naphthalene-1,4:5,8-bis(dicarboximide) radical anion (NDI(-)˙), which is easily produced by mild chemical or electrochemical reduction (-0.5 V vs. SCE), can be photoexcited at wavelengths as long as 785 nm, and has an excited state (NDI(-)˙*) oxidation potential of -2.1 V vs. SCE, making it a very attractive choice for artificial photosynthetic systems that require powerful photoreductants, such as CO2 reduction catalysts. However, once an electron is transferred from NDI(-)˙* to an acceptor directly bound to it, a combination of strong electronic coupling and favorable free energy change frequently make the back electron transfer rapid...
March 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28181616/na-k-atpase-as-a-target-for-anticancer-metal-based-drugs-insights-into-molecular-interactions-with-selected-gold-iii-complexes
#7
Aleksandra M Bondžić, Goran V Janjić, Miroslav D Dramićanin, Luigi Messori, Lara Massai, Tatjana N Parac Vogt, Vesna M Vasić
Na/K-ATPase is emerging as an important target for a variety of anticancer metal-based drugs. The interactions of Na/K-ATPase (in its E1 state) with three representative and structurally related cytotoxic gold(iii) complexes, i.e. [Au(bipy)(OH)2][PF6], bipy = 2,2'-bipyridine; [Au(py(dmb)-H)(CH3COO)2], py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine and [Au(bipy(dmb)-H)(OH)][PF6], bipy(c)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,2'-bipyridine, are investigated here in depth using a variety of spectroscopic methods, in combination with docking studies...
February 9, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28160119/synthesis-characterization-and-luminescence-sensitivity-with-variance-in-ph-dna-and-bsa-binding-studies-of-ru-ii-polypyridyl-complexes
#8
Ravi Kumar Vuradi, Srishailam Avudoddi, Venkat Reddy Putta, Laxma Reddy Kotha, Praveen Kumar Yata, Satyanarayana Sirasani
Three ruthenium(II) polypyridyl complexes, [Ru(phen)2(mip)](ClO4)2 (1) (phen =1,10-Phenanthroline), [Ru(bpy)2(mip)](ClO4)2 (2) (bpy = 2,2'bipyridyl) and [Ru(dmb)2(mip)](ClO4)2 (3) (dmb = 4, 4'-dimethyl 2, 2'-bipyridine), were synthesized with an intercalative ligand mip (2-morpholino-1H-imidazo[4,5-f][1, 10]phenanthroline) and characterized by (1)H, (13)C-NMR, IR, UV-vis, mass spectra and elemental analysis. pH effect, ion selectivity (cations, anions) and solvent sensitivity of complexes were studied. The interaction of these complexes with DNA was performed using absorption, emission spectroscopy and viscosity measurements...
February 3, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28060386/concentrations-of-a-triplet-excited-state-are-enhanced-in-illuminated-ice
#9
Zeyuan Chen, Cort Anastasio
Photochemical reactions influence the fates and lifetimes of organic compounds in snow and ice, both through direct photoreactions and via photoproduced transient species such as hydroxyl radical (˙OH) and, perhaps, triplet excited states of organic compounds (i.e., triplets). While triplets can be important oxidants in atmospheric drops and surface waters, little is known of this class of oxidants in frozen samples. To investigate this, we examined the photoreaction of phenol with the triplet state of 3,4-dimethoxybenzaldehyde ((3)DMB*), a product from biomass combustion, in illuminated laboratory ices...
January 25, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/27924438/correlation-between-molecular-modelling-and-spectroscopic-techniques-in-investigation-with-dna-binding-interaction-of-ruthenium-ii-complexes
#10
REVIEW
B Thulasiram, C Shobha Devi, Yata Praveen Kumar, Rajeshwar Rao Aerva, S Satyanarayana, Penumaka Nagababu
The DNA binding studies of rutheniumu(II) polypyridyl complexes {[Ru(phen)2Mipc](2+), [Ru(bpy)2Mipc](2+), [Ru(dmb)2Mipc](2+), [Ru(phen)2BrIPC](2+), [Ru(bpy)2BrIPC](2+), [Ru(dmb)2BrIPC](2+), [Ru(phen)2PIP-Cl](2+), [Ru(bpy)2PIP-Cl](2+), [Ru(dmb)2PIP-Cl](2+), [Ru(phen)2IPPBA](2+), [Ru(bpy)2IPPBA](2+), [Ru(dmb)2IPPBA](2+)} with DNA investigated by electronic absorption titration, emission and molecular modelling studies to identify the binding interactions. All these complexes are showing good binding constant values ~10(4) to 10(5)...
December 6, 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27900412/demethyleneberberine-alleviates-inflammatory-bowel-disease-in-mice-through-regulating-nf-%C3%AE%C2%BAb-signaling-and-t-helper-cell-homeostasis
#11
Ying-Ying Chen, Rui-Yan Li, Mei-Jing Shi, Ya-Xing Zhao, Yan Yan, Xin-Xin Xu, Miao Zhang, Xiao-Tong Zhao, Yu-Bin Zhang
OBJECTIVE: The activation of NF-κB signaling and unbalance of T-helper (Th) cells have been reported to play a key role in the pathogenesis of colitis. Cortex Phellodendri Chinensis (CPC) is commonly used to treat inflammation and diarrhea. Demethyleneberberine (DMB), a component of CPC, was reported to treat alcoholic liver disease as a novel natural mitochondria-targeted antioxidant in our previous study. In this study, we investigated whether DMB could protect against dextran sulfate sodium (DSS)-induced inflammatory colitis in mice by regulation of NF-κB pathway and Th cells homeostatis...
February 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27864098/screening-for-mucopolysaccharidoses-in-the-turkish-population-analytical-and-clinical-performance-of-an-age-range-specific-dye-based-urinary-glycosaminoglycan-assay
#12
Khaled El Moustafa, Serap Sivri, Sevilay Karahan, Turgay Coşkun, Filiz Akbıyık, İncilay Lay
Comprehensive analytical and diagnostic performance of urinary quantitative GAG analysis with dimethylmethylene blue (DMB) and the age-specific reference ranges were determined in Turkish population, which has a high incidence of MPSs. Precision, linearity, recovery and accuracy/trueness, limits, stability, and effect of interferents were tested according to CLSI guideline. Clinical performance was evaluated with ROC analyses including 45 MPS patients. Intra-day and inter-day precisions were <5% and <11% (CV), respectively...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27776613/do-dichromats-see-colours-in-this-way-assessing-simulation-tools-without-colorimetric-measurements
#13
Julio A Lillo Jover, Leticia Álvaro Llorente, Humberto Moreira Villegas, Anna Melnikova
BACKGROUND: Simulcheck evaluates Colour Simulation Tools (CSTs, they transform colours to mimic those seen by colour vision deficients). Two CSTs (Variantor and Coblis) were used to know if the standard Simulcheck version (direct measurement based, DMB) can be substituted by another (RGB values based) not requiring sophisticated measurement instruments. METHOD: Ten normal trichromats performed the two psychophysical tasks included in the Simulcheck method. The Pseudoachromatic Stimuli Identification task provided the h uv (hue angle) values of the pseudoachromatic stimuli: colours seen as red or green by normal trichromats but as grey by colour deficient people...
November 2016: Psicothema
https://www.readbyqxmd.com/read/27775635/polymorphisms-of-hla-dm-on-treatment-response-to-interferon-ribavirin-in-patients-with-chronic-hepatitis-c-virus-type-1-infection
#14
Hongbo Chen, Yinan Yao, Yifan Wang, Hua Zhou, Tianxiang Xu, Jing Liu, Guocheng Wang, Yongfeng Zhang, Xiang Chen, Qingwei Liu, Peng Huang, Rongbin Yu
BACKGROUND: HLA-DM gene, which is related to antigen processing and presentation and located in the non-classical class-II region of human leukocyte antigen (HLA) region, may play a crucial role in chronic hepatitis C virus (HCV) infection treatment outcomes. The study was conducted to evaluate the role of the variant of several single nucleotide polymorphisms (SNPs) in HLA-DM gene in HCV treatment outcomes. METHODS: We genotyped four SNPs from the candidate genes (HLA-DMA and DMB) in 336 patients who were treated with pegylated interferon-alpha and ribavirin (PEG IFN-α/RBV)...
October 20, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27748967/salmonella-enterica-synthesizes-5-6-dimethylbenzimidazolyl-dmb-%C3%AE-riboside-why-some-firmicutes-do-not-require-the-canonical-dmb-activation-system-to-synthesize-adenosylcobalamin
#15
Theodoric A Mattes, Jorge C Escalante-Semerena
5,6-Dimethylbenzimidazolyl-(DMB)-α-ribotide [α-ribazole-5'-phosphate (α-RP)] is an intermediate in the biosynthesis of adenosylcobalamin (AdoCbl) in many prokaryotes. In such microbes, α-RP is synthesized by nicotinate mononucleotide (NaMN):DMB phosphoribosyltransferases (CobT in Salmonella enterica), in a reaction that is considered to be the canonical step for the activation of the base of the nucleotide present in adenosylcobamides. Some Firmicutes lack CobT-type enzymes but have a two-protein system comprised of a transporter (i...
January 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/27665764/homogeneous-electrochemical-biosensor-for-melamine-based-on-dna-triplex-structure-and-exonuclease-iii-assisted-recycling-amplification
#16
Caili Fu, Chang Liu, Ying Li, Yajing Guo, Fang Luo, Peilong Wang, Longhua Guo, Bin Qiu, Zhenyu Lin
Abasic site (AP site) in the triplex structure can recognize specific target with high selectivity. In this study, this character was first applied to develop a simple, sensitive, and selective homogeneous electrochemical biosensor for melamine determination. The assay combines the advantage of the high selectivity of the DNA triplex structure containing an AP site to melamine and high efficiency of exonuclease (Exo) III-assisted recycling amplification. DNA-1 (T1), DNA-2 (T2), poly[dA] probe containing an AP site (8A) and methylene blue-labeled DNA probe (dMB probe) were carefully designed...
October 3, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27644852/brominated-flame-retardants-and-perfluoroalkyl-acids-in-groundwater-tile-drainage-soil-and-crop-grain-following-a-high-application-of-municipal-biosolids-to-a-field
#17
N Gottschall, E Topp, M Edwards, M Payne, S Kleywegt, D R Lapen
Dewatered municipal biosolids (DMB) were applied at a rate of 22Mgdwha(-1) to an agricultural field in fall 2008. Concentrations of polybrominated diphenyl ethers (PBDEs; BDE-47, -99, -100, -153, -154, -183, -197, -207, -209), other brominated flame retardants (BFRs; HBB, PBEB, DBDPE, BTBPE) and perfluoroalkyl acids (PFAAs; PFHxS, PFOS, PFDS, PFOSA, PFHpA, PFOA, PFNA, PFDA, PFUnA, PFDoA, PFTA) were monitored in tile drainage, groundwater (2m, 4m and 6m depth), soil cores (0-0.3m) pre- and post-application, DMB aggregates incorporated into the soil post-application, and in wheat (Triticum spp...
September 16, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27643733/non-isothermal-pyrolysis-of-de-oiled-microalgal-biomass-kinetics-and-evolved-gas-analysis
#18
Rahulkumar Maurya, Tonmoy Ghosh, Hitesh Saravaia, Chetan Paliwal, Arup Ghosh, Sandhya Mishra
Non-isothermal (β=5, 10, 20, 35°C/min) pyrolysis of de-oiled microalgal biomass (DMB) of Chlorella variabilis was investigated by TGA-MS (30-900°C, Argon atmosphere) to understand thermal decomposition and evolved gas analysis (EGA). The results showed that three-stage thermal decomposition and three volatilization zone (100-400°C, 400-550°C and 600-750°C) of organic matters during pyrolysis. The highest rate of weight-loss is 8.91%/min at 302°C for 35°C/min heating-rate. Kinetics of pyrolysis were investigated by iso-conversional (KAS, FWO) and model-fitting (Coats-Redfern) method...
December 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27634654/advantages-of-day-before-lymphoscintigraphy-and-undiluted-methylene-blue-dye-injections-for-sentinel-lymph-node-biopsies-for-melanoma
#19
COMPARATIVE STUDY
Kate H Dinh, Ariana F Harris, Jennifer LaFemina, Giles F Whalen, Mary Sullivan, Robert Licho, Thomas Hill, Laura A Lambert
BACKGROUND AND OBJECTIVES: Lymphatic mapping (LM) and blue dye injections are essential to identification of sentinel lymph nodes (SLN) for melanoma. LM is performed the day before (DB) or the same day (SD) of surgery, but the optimal timing is unknown. Similarly, methylene blue (MB), used during SLN biopsy (SLNB), is administered diluted (dMB) or undiluted (uMB), but the relative efficacies are unknown. METHODS: Patients who underwent SLNB for melanoma from 2009 to 2013 at our institution were evaluated...
December 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27589976/studies-on-photocleavage-dna-binding-cytotoxicity-and-docking-studies-of-ruthenium-ii-mixed-ligand-complexes
#20
Yata Praveen Kumar, C Shobha Devi, A Srishailam, N Deepika, V Ravi Kumar, P Venkat Reddy, K Nagasuryaprasad, Surya S Singh, Penumaka Nagababu, S Satyanarayana
This article describes the synthesis and characterization of three new Ru(II) polypyridyl complexes including [Ru(phen)2(dpphz)](2+) (1), [Ru(bpy)2(dpphz)](2+) (2) and [Ru(dmb)2(dpphz)](2+) (3) where dpphz = dipyrido[3,2-a:2',3'-c] phenazine-11-hydrazide, phen =1,10-phenanthroline, bpy = 2,2'-bipyridine and dmb = 4,4'-dimethyl2,2'-bipyridine. The binding behaviors of these complexes to calf thymus DNA (CT-DNA) were explored by spectroscopic titrations, viscosity measurements. Results suggest that these complexes can bind to CT-DNA through intercalation...
September 2, 2016: Journal of Fluorescence
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