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Uric acid AND cognition

Maria Teresa Pellecchia, Riccardo Savastano, Marcello Moccia, Marina Picillo, Pietro Siano, Roberto Erro, Annamaria Vallelunga, Marianna Amboni, Carmine Vitale, Gabriella Santangelo, Paolo Barone
Cognitive deficits are common in Parkinson's disease (PD) and many patients eventually develop dementia; however, its occurrence is unpredictable. Serum uric acid (UA) has been proposed as a biomarker of PD, both in the preclinical and clinical phase of the disease. The aim of this pilot study was to evaluate relationships between baseline serum UA levels and occurrence of mild cognitive impairment (MCI) at 4-year follow-up in a cohort of early PD patients. Early PD patients, not presenting concomitant diseases, cognitive impairment or treatment possibly interfering with UA levels, underwent neuropsychological testing at baseline and 4-year follow-up...
September 28, 2016: Journal of Neural Transmission
Linli Zhou, Ying Jiang, Cansheng Zhu, Lili Ma, Qiling Huang, Xiaohong Chen
OBJECTIVE: Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA). The aim of this study is to examine oxidant biomarkers including homocysteine (Hcys), bilirubin, uric acid, lipids, and potential environmental risk factors and to ascertain whether these data correlate with MSA in a Chinese population. METHODS: In this study, serum levels of Hcys, bilirubin, uric acid, and lipids were studied in 55 MSA patients and 76 healthy controls (HCs)...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Wei-Dong Hu, Jing Chen, Cheng-Jie Mao, Ping Feng, Ya-Ping Yang, Wei-Feng Luo, Chun-Feng Liu
OBJECTIVE: We investigated the relationship between serum cystatin C (CysC) levels and cognitive dysfunction and disease progression in patients with Parkinson disease. BACKGROUND: Previous studies have reported altered CysC levels in neurodegenerative disorders, but only a few studies have explored the role of CysC and its relationship to cognitive dysfunction in Parkinson disease. METHODS: We measured serum levels of CysC, creatinine, urea, and uric acid in 142 patients with Parkinson disease and 146 healthy controls...
September 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
G Desideri, R Gentile, A Antonosante, E Benedetti, D Grassi, L Cristiano, A Manocchio, S Selli, R Ippoliti, C Ferri, Claudio Borghi, A Giordano, Annamaria Cimini
There is still a considerable debate concerning whether uric acid is neuroprotective or neurotoxic agent. To clarify this topic we tested the effects of uric acid on neuronal cells biology by using differentiated SHSY5Y neuroblastoma cells incubated with amyloid ß to reproduce an in vitro model of Alzheimer's disease. The incubation of cells with uric acid at the dose of 40 µM or higher significantly reduced cell viability and potentiated the proapoptotic effect of amyloid ß. Finally, uric acid enhanced the generation of 4-hydroxynonenal and the expression of PPARβ/δ promoted by amyloid β, indicating a prooxidant effects...
July 30, 2016: Journal of Cellular Physiology
Yin Ting Cheung, Michelle N Edelmann, Daniel A Mulrooney, Daniel M Green, Wassim Chemaitilly, Neena John, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Hyperuricemia is implicated in cardiovascular and cerebrovascular diseases. This study evaluated associations between uric acid (UA), cardiovascular health, and neurocognitive function in adolescent and adult survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. METHODS: 126 adolescent [mean (SD) age 14.6 (5.0); 7.8 (1.7) years postdiagnosis] and 226 adult survivors [age 25.4 (4.2) years; 18.1 (4.4) years postdiagnosis] completed comprehensive neurocognitive testing...
August 2016: Cancer Epidemiology, Biomarkers & Prevention
Manuel Delgado-Alvarado, Belén Gago, Irene Navalpotro-Gomez, Haritz Jiménez-Urbieta, María C Rodriguez-Oroz
Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's disease. Around 30% of patients with Parkinson's disease experience mild cognitive impairment, a well-established risk factor for the development of dementia. However, mild cognitive impairment in patients with Parkinson's disease is a heterogeneous entity that involves different types and extents of cognitive deficits. Because it is not currently known which type of mild cognitive impairment confers a higher risk of progression to dementia, it would be useful to define biomarkers that could identify these patients to better study disease progression and possible interventions...
June 2016: Movement Disorders: Official Journal of the Movement Disorder Society
Laura Perna, Ute Mons, Ben Schöttker, Hermann Brenner
BACKGROUND: Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whether uric acid is an independent risk factor for cognitive dysfunction. METHODS: A population-based study was conducted in the German State of Saarland...
August 2016: Experimental Gerontology
May A Beydoun, Jose-Atilio Canas, Gregory A Dore, Hind A Beydoun, Ola S Rostant, Marie T Fanelli-Kuczmarski, Michele K Evans, Alan B Zonderman
Uric acid, a waste metabolite among humans, was linked to various cognitive outcomes. We describe sex and age-group specific associations of baseline serum uric acid (SUAbase) and significant change in SUA (ΔSUA: 1 versus 0 = decrease versus no change; 2 versus 0 = increase versus no change) with longitudinal annual rate of cognitive change among a large sample of urban adults. Data from the Healthy Aging in Neighborhoods of Diversity across the Life Span study, 2004-2009 (visit 1) and 2009-2013 (visit 2) were used...
April 21, 2016: Journal of Alzheimer's Disease: JAD
Qian Yao, Guo-Xin Jiang, Zhi-Ming Zhou, Jin-Mei Chen, Qi Cheng
BACKGROUND: Metabolic syndrome (MetS) maybe associated with mild cognitive impairment (MCI). OBJECTIVE: To investigate the relationship between MetS, with its individual or combined components, and MCI among elderly. METHODS: A case-control study was conducted among the elderly aged 65 years and over in a community located in the southwestern suburb of Shanghai, China. The Chinese version of the Mini-Mental Status Examination (C-MMSE) was used to screen subjects with MCI...
2016: Journal of Alzheimer's Disease: JAD
Tanya Khasnavis, Gail Reiner, Barbara Sommerfeld, William L Nyhan, Richard Chipkin, H A Jinnah
Lesch-Nyhan disease (LND) is an inherited metabolic disorder characterized by the overproduction of uric acid and distinct behavioral, cognitive, and motor abnormalities. The most challenging clinical problem is self-injurious behavior (SIB), which includes self-biting, self-hitting, self-abrasion, and other features. Currently, these behaviors are managed by behavioral extinction, sedatives, physical restraints, and removal of teeth. More effective treatments are needed. Pre-clinical studies have led to the hypothesis that D1-dopamine receptor antagonists may provide useful treatments for SIB in LND...
April 2016: Molecular Genetics and Metabolism
B S Ye, W W Lee, J H Ham, J J Lee, P H Lee, Y H Sohn
BACKGROUND AND PURPOSE: The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database. METHODS: In 271 healthy subjects, 596 mild cognitive impairment patients and 197 AD patients, serum uric acid and CSF AD biomarkers were measured at baseline, and Mini-Mental State Examination and AD Assessment Scale - Cognitive Subscale (ADAS-cog) were assessed serially (mean duration, 2...
May 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Diego Santos-García, Pablo Mir, Esther Cubo, Lydia Vela, Mari Cruz Rodríguez-Oroz, Maria José Martí, José Matías Arbelo, Jon Infante, Jaime Kulisevsky, Pablo Martínez-Martín
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms that can affect independence, social adjustment and the quality of life (QoL) of both patients and caregivers. Studies designed to find diagnostic and/or progression biomarkers of PD are needed. We describe here the study protocol of COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), an integral PD project based on four aspects/concepts: 1) PD as a global disease (motor and non-motor symptoms); 2) QoL and caregiver issues; 3) Biomarkers; 4) Disease progression...
2016: BMC Neurology
Aamir A Khan, Terence J Quinn, Jonathan Hewitt, Yuhua Fan, Jesse Dawson
Serum uric acid (sUA) level may be associated with cognitive impairment/dementia. It is possible this relationship varies with dementia subtype, particularly between vascular dementias (VaD) and Alzheimer's (AD) or Parkinson's disease (PDD)-related dementia. We aimed to present a synthesis of all published data on sUA and relationship with dementia/cognition through systematic review and meta-analysis. We included studies that assessed the association between sUA and any measure of cognitive function or a clinical diagnosis of dementia...
February 2016: Age (2005-)
Li Feng, Hong-wei Wu, Guang-qing Song, Cong Lu, Ying-hui Li, Li-na Qu, Shan-guang Chen, Xin-min Liu, Qi Chang
Good sleep is necessary for optimal health, especially for mental health. Insomnia, sleep deprivation will make your ability to learn and memory impaired. Nevertheless, the underlying pathophysiological mechanism of sleep disorders-induced cognitive decline is still largely unknown. In this study, the sleep deprivation of animal model was induced by chronical sleep interruption (CSI), the behavioral tests, biochemical index determinations, and a liquid chromatography-mass spectrometry (LC-MS) based serum metabolic profiling analysis were performed to explore the effects of CSI on cognitive function and the underlying mechanisms...
April 1, 2016: Behavioural Brain Research
Marina Picillo, Gabriella Santangelo, Marcello Moccia, Roberto Erro, Marianna Amboni, Elio Prestipino, Katia Longo, Carmine Vitale, Emanuele Spina, Giuseppe Orefice, Paolo Barone, Maria Teresa Pellecchia
Both low serum uric acid (UA) levels and apathy are considered biomarkers of cognitive decline and dementia in Parkinson's disease (PD). There is an urgent need to combine different biomarkers to predict disease course in PD. Data on the relationship between serum UA levels and apathy in PD are lacking. The aim of this study is to evaluate the relationship between serum UA levels and pure apathy in early, drug-naïve PD patients. Forty-nine early, drug-naïve PD patients were enrolled and stratified into two groups using the median serum UA levels at diagnosis (Group 1 serum UA ≤ 4...
April 2016: Journal of Neural Transmission
Hui Gao, Lijun Chen, Jianjun Xu, Fang Yang, Xiaoqi Wang, Dongzhou Liu
OBJECTIVE: To study the compliance and its related factors of gout patients during the intercritical period. METHODS: A total of 218 gout patients were recruited. Compliance and cognition of gout were evaluated via telephone interview. Case control study was performed between compliance patients and non-compliance ones to explore the factors affecting patients' compliance. The association between compliance scores and cognition scores was evaluated by linear regression and correlation analysis...
July 21, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Hirokuni Hatanaka, Haruo Hanyu, Raita Fukasawa, Kentaro Hirao, Soichiro Shimizu, Hidekazu Kanetaka, Toshihiko Iwamoto
AIMS: We determined whether the possible roles of oxidative stress differ in the pathophysiology and cognitive decline of Alzheimer's disease (AD), vascular dementia (VaD) and mixed Alzheimer's/vascular dementia (MD). METHODS: We measured the levels of diacron reactive oxygen metabolite (dROM), reflecting the amount of organic hydroperoxides, and biological anti-oxidant potential (BAP), measuring the ferric reducing ability of blood plasma, in 72 patients with AD, 27 with VaD, 24 with MD and 53 non-demented outpatients (control group)...
December 2015: Geriatrics & Gerontology International
Bei Cao, Qian-Qian Wei, Ruwei Ou, Jing Yang, Hui-Fang Shang
BACKGROUND AND OBJECTIVE: Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA) and cognitive impairment. Uric acid has an anti-oxidative effect. Our objective is to clarify the correlations between serum uric acid and cognitive function as well as frontal lobe function in Chinese MSA patients. METHODS: All of MSA patients were evaluated using Addenbrooke's Cognitive Examination-Revised (ACE-R), Frontal Assessment Battery (FAB), and Unified MSA Rating Scale (UMSARS)...
December 15, 2015: Journal of the Neurological Sciences
Hirokuni Hatanaka, Haruo Hanyu, Raita Fukasawa, Tomohiko Sato, Soichiro Shimizu, Hirofumi Sakurai
AIMS: We previously found that there was a dementia subgroup with characteristics predominantly associated with diabetes mellitus (DM)-related metabolic abnormalities, referred to as "diabetes-related dementia (DrD)." We determined the possible role of oxidative stress in the pathophysiology of DrD. METHODS: In a 2013 study, we classified 175 patients with clinically diagnosed Alzheimer's disease (AD) and DM into four subgroups based on brain imaging. Among them, we measured endogenous plasma anti-oxidants, such as albumin, unconjugated bilirubin and uric acid, and urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in 58 patients of an AD group showing decreased regional cerebral blood flow of the parietotemporal lobe on single-photon emission computed tomography (AD+DM group), and in 35 patients of a DrD group showing neither decreased regional cerebral blood flow of the parietotemporal lobe nor cerebrovascular disease on magnetic resonance imaging, which is strongly associated with DM-related factors...
November 4, 2015: Geriatrics & Gerontology International
Min Yuan, Lijun Xu, Xiaoping Yin
Alzheimer's disease (AD) is a very common neurodegenerative disorder of the central nervous system, characterized by dementia, cognitive impairment, and memory loss, and the global prevalence is increasing. Many epidemiologic studies have considered the association between uric acid and AD, yet the relationship remains elusive. The objective of this study was to validate whether or not uric acid is indeed associated with AD. We compared different prospective studies and ultimately found that it is also a controversial issue...
May 2016: American Journal of Alzheimer's Disease and Other Dementias
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