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Uric acid AND cognition

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https://www.readbyqxmd.com/read/28529242/hyperuricemia-as-a-protective-factor-for-mild-cognitive-impairment-in-non-obese-elderly
#1
Feng Wang, Minghui Zhao, Zhaoli Han, Dai Li, Shishuang Zhang, Yongqiang Zhang, Xiaodong Kong, Ning Sun, Qiang Zhang, Ping Lei
Mild cognitive impairment (MCI) is regarded as incipient dementia. Patients with MCI have increased risk of later progressing to dementia. Blood uric acid (UA) is an important non-enzymatic antioxidant in peripheral circulation, and plays an unconfirmed protective role in MCI. Furthermore, obesity-induced inflammation, which affects UA metabolism and MCI onset, might regulate such protective role. Thus, the aim of the study was to determine the relationship of UA to MCI and the potential effect from inflammation...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28489814/diagnostic-values-of-serum-levels-of-homocysteine-and-uric-acid-for-predicting-vascular-mild-cognitive-impairment-in-patients-with-cerebral-small-vessel-disease
#2
Ting Wang, Zhong-Wu Sun, Liang-Qing Shao, Xiao-Bin Xu, Yang Liu, Mao Qin, Xiang Weng, Yong-Xiang Zhang
BACKGROUND This study aimed to investigate the diagnostic values of serum levels of Hcy and UA for predicting vascular mild cognitive impairment (VMCI) in patients with cerebral small vessel disease (SVD). MATERIAL AND METHODS We selected 172 cerebral SVD patients and divided them into a VMCI group and a non-VMCI group. Eighty-six healthy individuals without nervous system diseases were selected as the control group. Enzymatic cycling method was performed to detect serum Hcy and UA levels. Serum levels of folic acid (FOA) and vitamin B12 (VitB12) were detected by chemiluminescence immunoassay...
May 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28420204/fructose-intake-serum-uric-acid-and-cardiometabolic-disorders-a-critical-review
#3
REVIEW
Cristiana Caliceti, Donato Calabria, Aldo Roda, Arrigo F G Cicero
There is a direct relationship between fructose intake and serum levels of uric acid (UA), which is the final product of purine metabolism. Recent preclinical and clinical evidence suggests that chronic hyperuricemia is an independent risk factor for hypertension, metabolic syndrome, and cardiovascular disease. It is probably also an independent risk factor for chronic kidney disease, Type 2 diabetes, and cognitive decline. These relationships have been observed for high serum UA levels (>5.5 mg/dL in women and >6 mg/dL in men), but also for normal to high serum UA levels (5-6 mg/dL)...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28387669/a-prospective-study-on-the-association-between-uric-acid-and-cognitive-function-among-middle-aged-and-older-chinese
#4
Tong Wang, Yili Wu, Yongye Sun, Long Zhai, Dongfeng Zhang
BACKGROUND: Uric acid (UA) is a powerful antioxidant that may have neuroprotective properties, yet it is also a risk factor of vascular disease that predisposes individuals to cognitive impairment. Results from longitudinal studies on UA and cognitive decline remain controversial. OBJECTIVE: We examined the associations of baseline plasma UA level with follow-up cognitive function as well as cognitive decline over time among a large sample of middle-aged and older Chinese...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28300627/serum-uric-acid-is-associated-with-better-executive-function-in-men-but-not-in-women-baseline-assessment-of-the-elsa-brasil-study
#5
Cristina Pellegrino Baena, Claudia Kimie Suemoto, Sandhi Maria Barreto, Paulo Andrade Lotufo, Isabela Benseñor
BACKGROUND: Serum uric acid (SUA) may protect against free radical stress damage and was previously linked to cognitive impairment in older adults, but evidence in middle-aged adults is scarce. PURPOSE: We sought to analyze whether SUA is associated with cognitive performance in apparently healthy middle-aged participants in the ELSA-Brasil cohort study. METHODS: We excluded participants older than age 65, those taking allopurinol, benzbromarone, or medications that could impair cognitive performance, those with previous stroke, and those with incomplete data on cognitive tests or SUA...
June 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28251464/serum-uric-acid-levels-and-freezing-of-gait-in-parkinson-s-disease
#6
Ruwei Ou, Bei Cao, Qianqian Wei, Yanbing Hou, Yaqian Xu, Wei Song, Bi Zhao, Huifang Shang
Uric acid (UA) is a natural antioxidant and iron scavenger in the human body, which has been hypothesized to exert an anti-oxidative effect in Parkinson's disease (PD). This study aimed to investigate the relationship between serum UA levels and freezing of gait (FOG) in PD. A total of 321 Chinese PD patients with fasting serum UA evaluated were included in the cross-sectional study. Demographics, clinical features, and therapeutic regimen were collected. The Unified PD Rating Scale (UPDRS) III and Hoehn and Yahr (H and Y) stage were used to evaluate the severity of disease, and the Frontal Assessment Battery (FAB) and Montreal Cognitive Assessment (MoCA) scales were used to assess the cognitive function...
March 1, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28239527/uric-acid-is-associated-with-vascular-dementia-in-chinese-population
#7
Yuzhen Xu, Qian Wang, Ruiting Cui, Kaili Lu, Yunlin Liu, Yuwu Zhao
OBJECTIVE: Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD. MATERIALS AND METHODS: There were altogether 127 VD subjects and 81 nondemented controls enrolled in our study...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28203247/elevated-serum-uric-acid-levels-are-related-to-cognitive-deterioration-in-an-elderly-japanese-population
#8
Kazushi Suzuki, Daisuke Koide, Kurumi Fujii, Tsutomu Yamazaki, Shoji Tsuji, Atsushi Iwata
AIMS: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. METHODS: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsychological test results, clinical data as well as brain magnetic resonance imaging data. PATIENTS: Overall, 64 participants were diagnosed with cognitive deterioration...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28062372/uric-acid-may-be-protective-against-cognitive-impairment-in-older-adults-but-only-in-those-without-cardiovascular-risk-factors
#9
Busra Tuven, Pinar Soysal, Gulcin Unutmaz, Derya Kaya, Ahmet Turan Isik
Uric acid (UA) may not only prevent development of cognitive dysfunction owing to its antioxidant efficacy, but also may worsen cognitive functions by gaining pro-oxidant character. The present study attempts to uncover this paradoxical association between UA and cognitive impairment in elderly. 1374 elderly patients were retrospectively evaluated and included in the study. Participants underwent determination of circulating UA levels and comprehensive geriatric assessment. A serum UA concentration≥7.0mg/dL in males and ≥5...
January 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/27916816/blueberry-consumption-affects-serum-uric-acid-concentrations-in-older-adults-in-a-sex-specific-manner
#10
Carol L Cheatham, Itzel Vazquez-Vidal, Amanda Medlin, V Saroja Voruganti
Blueberries are rich in antioxidants and may protect against disease. Uric acid accounts for about 50% of the antioxidant properties in humans. Elevated levels of serum uric acid (SUA) or hyperuricemia is a risk factor for cardiovascular disease (CVD). The aim was to determine the effect of blueberries on SUA in older adults. Participants (n = 133, 65-80 years) experiencing mild cognitive impairment (MCI) were randomized in a double-blind 6-month clinical trial to either blueberry or placebo. A reference group with no MCI received no treatment...
November 29, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27913745/the-association-of-uric-acid-with-leukoaraiosis
#11
Jun-Jing Li, Yin-Hui Huang, You-Yu Lin, Mi-Mi Li, Ya-Fang Chen, Ruo-Wei Cai
Objective To explore the possible correlation between uric acid levels and leukoaraiosis (LA). Methods This cross-sectional study enrolled patients who presented with some neurological discomfort (e.g. dizziness, headache, mild cognitive impairment). Potential demographic and clinical risk factors associated with LA, including sex, age, hypertension, diabetes mellitus, smoking, alcohol consumption, dyslipidaemia, plasma fibrinogen, D-dimer, uric acid, and homocysteine, were investigated using univariate and multivariate logistic regression analyses...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/27890742/serum-uric-acid-and-impaired-cognitive-function-in-community-dwelling-elderly-in-beijing
#12
Shuangling Xiu, Zheng Zheng, Shaochen Guan, Jin Zhang, Jinghong Ma, Piu Chan
The relationship between serum uric acid (sUA) and cognitive function is contradictory. This study assessed the association between sUA and cognitive impairment in 10,039 community-dwelling subjects aged ≥55years living in Beijing, China. Participants underwent determination of sUA and an evaluation of cognitive function using the scholarship-adjusted Mini-Mental State Examination (MMSE): MMSE ≤17 for illiterates; MMSE≤20 for primary school graduates (≥6years of education); and MMSE≤24 for junior school graduates or above (≥9years of education)...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27798180/uric-acid-induces-cognitive-dysfunction-through-hippocampal-inflammation-in-rodents-and-humans
#13
Xiaoni Shao, Wenjie Lu, Fabao Gao, Dandan Li, Jing Hu, Yan Li, Zeping Zuo, Hui Jie, Yinglan Zhao, Xiaobo Cen
Uric acid (UA) is a purine metabolite that in most mammals is degraded by the hepatic enzyme uricase to allantoin. Epidemiological studies have shown that an elevated UA level predicts the development of cognition and memory deficits; however, there is no direct evidence of this relationship, and the underlying mechanism is largely undefined. Here, we show that a high-UA diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB pathway, and increases gliosis in the hippocampus of Wistar rats...
October 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27785947/increased-non-protein-bound-iron-in-down-syndrome-contribution-to-lipid-peroxidation-and-cognitive-decline
#14
Caterina Manna, Arbace Officioso, Francesca Trojsi, Gioacchino Tedeschi, Silvia Leoncini, Cinzia Signorini, Lucia Ciccoli, Claudio De Felice
Down syndrome (DS, trisomy 21) is the leading cause of chromosomal-related intellectual disability. At an early age, adults with DS develop with the neuropathological hallmarks of Alzheimer's disease, associated with a chronic oxidative stress. To investigate if non-protein bound iron (NPBI) can contribute to building up a pro-oxidative microenvironment, we evaluated NPBI in both plasma and erythrocytes from DS and age-matched controls, together with in vivo markers of lipid peroxidation (F2-isoprostanes, F2-dihomo-isoprostanes, F4-neuroprostanes) and in vitro reactive oxygen species (ROS) formation in erythrocytes...
December 2016: Free Radical Research
https://www.readbyqxmd.com/read/27682634/lower-serum-uric-acid-is-associated-with-mild-cognitive-impairment-in-early-parkinson-s-disease-a-4-year-follow-up-study
#15
Maria Teresa Pellecchia, Riccardo Savastano, Marcello Moccia, Marina Picillo, Pietro Siano, Roberto Erro, Annamaria Vallelunga, Marianna Amboni, Carmine Vitale, Gabriella Santangelo, Paolo Barone
Cognitive deficits are common in Parkinson's disease (PD) and many patients eventually develop dementia; however, its occurrence is unpredictable. Serum uric acid (UA) has been proposed as a biomarker of PD, both in the preclinical and clinical phase of the disease. The aim of this pilot study was to evaluate relationships between baseline serum UA levels and occurrence of mild cognitive impairment (MCI) at 4-year follow-up in a cohort of early PD patients. Early PD patients, not presenting concomitant diseases, cognitive impairment or treatment possibly interfering with UA levels, underwent neuropsychological testing at baseline and 4-year follow-up...
December 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27670212/oxidative-stress-and-environmental-exposures-are-associated-with-multiple-system-atrophy-in-chinese-patients
#16
Linli Zhou, Ying Jiang, Cansheng Zhu, Lili Ma, Qiling Huang, Xiaohong Chen
OBJECTIVE: Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA). The aim of this study is to examine oxidant biomarkers including homocysteine (Hcys), bilirubin, uric acid, lipids, and potential environmental risk factors and to ascertain whether these data correlate with MSA in a Chinese population. METHODS: In this study, serum levels of Hcys, bilirubin, uric acid, and lipids were studied in 55 MSA patients and 76 healthy controls (HCs)...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27662452/elevated-cystatin-c-levels-are-associated-with-cognitive-impairment-and-progression-of-parkinson-disease
#17
Wei-Dong Hu, Jing Chen, Cheng-Jie Mao, Ping Feng, Ya-Ping Yang, Wei-Feng Luo, Chun-Feng Liu
OBJECTIVE: We investigated the relationship between serum cystatin C (CysC) levels and cognitive dysfunction and disease progression in patients with Parkinson disease. BACKGROUND: Previous studies have reported altered CysC levels in neurodegenerative disorders, but only a few studies have explored the role of CysC and its relationship to cognitive dysfunction in Parkinson disease. METHODS: We measured serum levels of CysC, creatinine, urea, and uric acid in 142 patients with Parkinson disease and 146 healthy controls...
September 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27474828/uric-acid-amplifies-a%C3%AE-amyloid-effects-involved-in-the-cognitive-dysfunction-dementia-evidences-from-an-experimental-model-in-vitro
#18
Giovambattista Desideri, Roberta Gentile, Andrea Antonosante, Elisabetta Benedetti, Davide Grassi, Loredana Cristiano, Antonello Manocchio, Sara Selli, Rodolfo Ippoliti, Claudio Ferri, Claudio Borghi, Antonio Giordano, Annamaria Cimini
There is still a considerable debate concerning whether uric acid is neuroprotective or neurotoxic agent. To clarify this topic, we tested the effects of uric acid on neuronal cells biology by using differentiated SHSY5Y neuroblastoma cells incubated with amyloid β to reproduce an in vitro model of Alzheimer's disease. The incubation of cells with uric acid at the dose of 40 µM or higher significantly reduced cell viability and potentiated the proapoptotic effect of amyloid β. Finally, uric acid enhanced the generation of 4-hydroxynonenal and the expression of PPARβ/δ promoted by amyloid β, indicating a prooxidant effects...
May 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27345588/uric-acid-and-neurocognitive-function-in-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-chemotherapy-only
#19
Yin Ting Cheung, Michelle N Edelmann, Daniel A Mulrooney, Daniel M Green, Wassim Chemaitilly, Neena John, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Hyperuricemia is implicated in cardiovascular and cerebrovascular diseases. This study evaluated associations between uric acid (UA), cardiovascular health, and neurocognitive function in adolescent and adult survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. METHODS: 126 adolescent [mean (SD) age 14.6 (5.0); 7.8 (1.7) years postdiagnosis] and 226 adult survivors [age 25.4 (4.2) years; 18.1 (4.4) years postdiagnosis] completed comprehensive neurocognitive testing...
August 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27193487/biomarkers-for-dementia-and-mild-cognitive-impairment-in-parkinson-s-disease
#20
REVIEW
Manuel Delgado-Alvarado, Belén Gago, Irene Navalpotro-Gomez, Haritz Jiménez-Urbieta, María C Rodriguez-Oroz
Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's disease. Around 30% of patients with Parkinson's disease experience mild cognitive impairment, a well-established risk factor for the development of dementia. However, mild cognitive impairment in patients with Parkinson's disease is a heterogeneous entity that involves different types and extents of cognitive deficits. Because it is not currently known which type of mild cognitive impairment confers a higher risk of progression to dementia, it would be useful to define biomarkers that could identify these patients to better study disease progression and possible interventions...
June 2016: Movement Disorders: Official Journal of the Movement Disorder Society
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