Thitima Benjachat Suttichet, Monpat Chamnanphon, Monnat Pongpanich, Sarun Chokyakorn, Pawinee Kupatawintu, Chalurmpon Srichomthong, Wanna Chetruengchai, Hathaichanok Chuntakaruk, Thanyada Rungrotmongkol, Pajaree Chariyavilaskul, Vorasuk Shotelersuk, Kearkiat Praditpornsilpa
Treatment of anemia in patients with chronic kidney disease (CKD) with recombinant human erythropoietin (rHuEPO) can be disrupted by a severe complication, anti-rHuEPO-induced pure red cell aplasia (PRCA). Specific HLA genotypes may have played a role in the high incidence of PRCA in Thai patients (1.7/1,000 patient years vs. 0.03/10,000 patient years in Caucasians). We conducted a case-control study in 157 CKD patients with anti-rHuEPO-induced PRCA and 56 controls. The HLA typing was determined by sequencing using a highly accurate multiplex single-molecule, real-time, long-read sequencing platform...
December 20, 2023: Scientific Reports