keyword
MENU ▼
Read by QxMD icon Read
search

visual pharmacology

keyword
https://www.readbyqxmd.com/read/29450484/neurological-manifestations-among-us-government-personnel-reporting-directional-audible-and-sensory-phenomena-in-havana-cuba
#1
Randel L Swanson, Stephen Hampton, Judith Green-McKenzie, Ramon Diaz-Arrastia, M Sean Grady, Ragini Verma, Rosette Biester, Diana Duda, Ronald L Wolf, Douglas H Smith
Importance: From late 2016 through August 2017, US government personnel serving on diplomatic assignment in Havana, Cuba, reported neurological symptoms associated with exposure to auditory and sensory phenomena. Objective: To describe the neurological manifestations that followed exposure to an unknown energy source associated with auditory and sensory phenomena. Design, Setting, and Participants: Preliminary results from a retrospective case series of US government personnel in Havana, Cuba...
February 15, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29428822/intranasal-bdnf-administration-promotes-visual-function-recovery-in-adult-amblyopic-rats
#2
REVIEW
Gabriele Sansevero, Laura Baroncelli, Manuela Scali, Alessandro Sale
Amblyopia is the most common cause of visual impairment in one eye, with a prevalence of 1-5% in the world population. While amblyopia can be efficiently treated in children, it becomes irreversible in adults, due to the decline in neural plasticity past the end of the visual cortex critical period. Accordingly, no pharmacological approaches are available to rescue visual functions in adult amblyopic subjects. We report that non-invasive intranasal infusion of BDNF increased levels of this neurotrophic factor in V1 and induced a recovery of visual acuity, ocular dominance and visual depth perception in adult amblyopic rats, both in reverse-occluded animals and in those with unrestricted binocular sight...
February 8, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29425263/determinants-of-optogenetic-cortical-spreading-depolarizations
#3
David Y Chung, Homa Sadeghian, Tao Qin, Sevda Lule, Hang Lee, Fahri Karakaya, Stacy Goins, Fumiaki Oka, Mohammad A Yaseen, Thijs Houben, Else A Tolner, Arn M J M van den Maagdenberg, Michael J Whalen, Sava Sakadžic, Cenk Ayata
Cortical spreading depolarization (SD) is the electrophysiological event underlying migraine aura, and a critical contributor to secondary damage after brain injury. Experimental models of SD have been used for decades in migraine and brain injury research; however, they are highly invasive and often cause primary tissue injury, diminishing their translational value. Here we present a non-invasive method to trigger SDs using light-induced depolarization in transgenic mice expressing channelrhodopsin-2 in neurons (Thy1-ChR2-YFP)...
February 7, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29422437/effect-of-cold-pack-therapy-for-management-of-burn-scar-pruritus-a-pilot-study
#4
So Young Joo, June-Bum Kim, Yoon Soo Cho, Yong Suk Cho, Cheong Hoon Seo
PURPOSE: Pruritus, a common, chronically disabling condition is often refractory to treatment. The pruritus sensation is mediated in the spinal cord and post-burn pruritus is considered a form of neuropathic pain. We investigated cold pack therapy as a treatment modality for post-burn pruritus. METHODS: We studied 23 patients with severe pruritus scoring at least 5 on the visual analogue scale (VAS) and refractory to antihistamine and gabapentin administration. Each cold pack therapy lasted more than 20min...
February 5, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29422164/understanding-how-patients-use-visualization-during-ablation-of-atrial-fibrillation-in-reducing-their-experience-of-pain-anxiety-consumption-of-pain-medication-and-procedure-length-integrating-quantitative-and-qualitative-results
#5
Marianne W Nørgaard, Preben U Pedersen, Merete Bjerrum
BACKGROUND: Patients who undergo radiofrequency ablation of atrial fibrillation with a light conscious sedation often feel pain during the procedure which can be difficult to relieve with pharmacological pain treatment alone. In a quasi-experimental study, it was found that visualization together with usual pain medication reduced the amount of analgesics used. In addition, patients spontaneously expressed pain significantly fewer times outside the scheduled measurements. No difference was found in the perception of pain intensity or anxiety and procedure length in the study...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29420565/catecholamines-alter-the-intrinsic-variability-of-cortical-population-activity-and-perception
#6
Thomas Pfeffer, Arthur-Ervin Avramiea, Guido Nolte, Andreas K Engel, Klaus Linkenkaer-Hansen, Tobias H Donner
The ascending modulatory systems of the brain stem are powerful regulators of global brain state. Disturbances of these systems are implicated in several major neuropsychiatric disorders. Yet, how these systems interact with specific neural computations in the cerebral cortex to shape perception, cognition, and behavior remains poorly understood. Here, we probed into the effect of two such systems, the catecholaminergic (dopaminergic and noradrenergic) and cholinergic systems, on an important aspect of cortical computation: its intrinsic variability...
February 8, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29414666/dexamethasone-restores-transforming-growth-factor-%C3%AE-activated-kinase-1-expression-and-phagocytosis-activity-of-kupffer-cells-in-cholestatic-liver-injury
#7
Chih-Sung Hsieh, Jiin-Haur Chuang, Ming-Huei Chou, Ying-Hsien Kao
The role of transforming growth factor-β activated kinase 1 (TAK1) in modulating the function of Kupffer cells (KCs) within cholestatic livers remains unclear. This study examined the immunopharmacological action of dexamethasone (DEX) in modulating hepatic TAK1 expression and related signaling activity in a rat model of bile duct ligation-mimicked obstructive jaundice. The in vitro effects of DEX on porcine biliary extract (PBE)-modulated gene expression and phagocytosis of KCs were examined using a rat alveolar macrophage cell line (NR8383 cells)...
February 4, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29410359/modulation-of-the-zebrafish-optokinetic-reflex-by-pharmacologic-agents-targeting-gabaa-receptors
#8
Enhua Shao, Seth D Scheetz, Wenting Xie, Edward A Burton
Optokinetic reflex (OKR) responses provide a convenient means to evaluate visual, integrative and oculomotor function in larval zebrafish. We measured multiple aspects of the OKR response in zebrafish exposed systemically to compounds altering signaling at GABAA receptors in order to derive quantitative concentration-response relationships. The GABAA antagonist picrotoxin caused concentration-dependent decreases in reflex gain, saccade velocity, saccade amplitude, interocular concordance and interocular gain...
February 2, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29408282/pharmacological-manipulation-of-gaba-activity-in-nucleus-subpretectalis-interstitio-pretecto-subpretectalis-sp-ips-impairs-figure-ground-discrimination-in-pigeons-running-head-sp-ips-in-figure-ground-segregation
#9
Martin J Acerbo, Olga F Lazareva
Figure-ground segregation is a fundamental visual ability that allows an organism to separate an object from its background. Our earlier research has shown that nucleus rotundus (Rt), a thalamic nucleus processing visual information in pigeons, together with its inhibitory complex, nucleus subpretectalis/interstitio-pretecto-subpretectalis (SP/IPS), are critically involved in figure-ground discrimination (Acerbo et al., 2012; Scully et al., 2014). Here, we further investigated the role of SP/IPS by conducting bilateral microinjections of GABAergic receptor antagonist and agonists (bicuculline and muscimol, respectively) and non-NMDA glutamate receptor antagonist (CNQX) after the pigeons mastered figure-ground discrimination task...
February 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29407363/society-of-family-planning-clinical-guidelines-pain-control-in-surgical-abortion-part-1-local-anesthesia-and-minimal-sedation
#10
REVIEW
Rebecca H Allen, Rameet Singh
Satisfactory pain control for women undergoing surgical abortion is important for patient comfort and satisfaction. Clinicians ought to be aware of the safety and efficacy of different pain control regimens. This document will focus on nonpharmacologic modalities to reduce pain and pharmacologic interventions up to the level of minimal sedation. For surgical abortion without intravenous medications, a multimodal approach to pain control may combine a dedicated emotional-support person, visual or auditory distraction, administration of local anesthesia to the cervix with buffered lidocaine, and a preoperative nonsteroidal anti-inflammatory drug...
January 30, 2018: Contraception
https://www.readbyqxmd.com/read/29403261/maximum-human-objectively-measured-pharmacologically-stimulated-accommodative-amplitude
#11
Andrzej Grzybowski, Ronald A Schachar, Magdalena Gaca-Wysocka, Ira H Schachar, Barbara K Pierscionek
Purpose: To measure the maximum, objectively measured, accommodative amplitude, produced by pharmacologic stimulation. Methods: Thirty-seven healthy subjects were enrolled, with a mean age of 20.2±1.1 years, corrected visual acuity of 20/20, and mean spherical equivalent refraction (SER) =-0.83±1.60 diopters. For each subject, the right pupil was dilated with phenylephrine 10%. After 30 minutes, the pupil was measured, the left eye was patched, and the right eye was autorefracted...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29392311/effect-of-anti-c5a-therapy-in-a-murine-model-of-early-intermediate-dry-age-related-macular-degeneration
#12
Christopher B Toomey, Michael Landowski, Mikael Klingeborn, Una Kelly, John Deans, Holly Dong, Ons Harrabi, Thomas Van Blarcom, Yik Andy Yeung, Ruslan Grishanin, John C Lin, Daniel R Saban, Catherine Bowes Rickman
Purpose: A large body of evidence supports a central role for complement activation in the pathobiology of age-related macular degeneration (AMD), including plasma complement component 5a (C5a). Interestingly, C5a is a chemotactic agent for monocytes, a cell type also shown to contribute to AMD. However, the role monocytes play in the pathogenesis of "dry" AMD and the pharmacologic potential of targeting C5a to regulate these cells are unclear. We addressed these questions via C5a blockade in a unique model of early/intermediate dry AMD and large panel flow cytometry to immunophenotype monocytic involvement...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29390337/linezolid-associated-optic-neuropathy-in-a-pediatric-patient-with-mycobacterium-nonchromogenicum-a-case-report
#13
Napoleón González Saldaña, Diego Mauricio Galvis Trujillo, Ana Maria Borbolla Pertierra, Ana Ivette Mondragón Pineda, Hugo Juárez Olguín
BACKGROUND: Toxic optic neuropathies are alterations of the optic nerve and can be caused by environmental, pharmacological, or nutritional agents. CASE: It is about a 7-year-old male patient, a native of the State of Mexico, Mexico who was diagnosed with cervical mycobacterial lymphadenitis that required management with linezolid. OBSERVATIONS: After 7 months of treatment, visual acuity of the left eye decreased and was accompanied by headache...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390089/physical-activity-behaviour-in-men-with-inflammatory-joint-disease-a-cross-sectional-register-based-study
#14
Nanna Maria Hammer, Julie Midtgaard, Merete Lund Hetland, Niels Steen Krogh, Bente Appel Esbensen
Objectives: Physical activity is recommended as an essential part of the non-pharmacological management of inflammatory joint disease, but previous research in this area has predominantly included women. The aim of this study was to examine physical activity behaviour in men with inflammatory joint disease. Methods: The study was conducted as a cross-sectional register-based study. Data on physical activity behaviour in men with RA, PsA and AS were matched with sociodemographic and clinical variables extracted from the DANBIO registry...
January 29, 2018: Rheumatology
https://www.readbyqxmd.com/read/29386432/-adverse-effect-predictions-based-on-computational-toxicology-techniques-and-large-scale-databases
#15
Yoshihiro Uesawa
 Understanding the features of chemical structures related to the adverse effects of drugs is useful for identifying potential adverse effects of new drugs. This can be based on the limited information available from post-marketing surveillance, assessment of the potential toxicities of metabolites and illegal drugs with unclear characteristics, screening of lead compounds at the drug discovery stage, and identification of leads for the discovery of new pharmacological mechanisms. This present paper describes techniques used in computational toxicology to investigate the content of large-scale spontaneous report databases of adverse effects, and it is illustrated with examples...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29386244/in-vivo-imaging-of-emerging-endocrine-cells-reveals-a-requirement-for-pi3k-regulated-motility-in-pancreatic-islet-morphogenesis
#16
Julia Freudenblum, José A Iglesias, Martin Hermann, Tanja Walsen, Armin Wilfinger, Dirk Meyer, Robin A Kimmel
The three-dimensional architecture of the pancreatic islet is critical for beta cell function, but the process of islet formation remains poorly understood due to the difficulties of imaging internal organs with cellular resolution. Within transparent zebrafish larvae, the developing pancreas is relatively superficial and thus amenable to live imaging approaches. We performed in vivo time lapse and longitudinal imaging studies to follow islet develoment, visualizing both naturally occuring islet cells and cells arising with an accelerated time course following an induction approach...
January 31, 2018: Development
https://www.readbyqxmd.com/read/29379312/intra-articular-ozone-or-hyaluronic-acid-injection-which-one-is-superior-in-patients-with-knee-osteoarthritis-a-6-month-randomized-clinical-trial
#17
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Bijan Forogh, Porya Hassan Abadi, Mahsa Moridnia, Shahram Rahimi Dehgolan
Purpose: Knee osteoarthritis (OA) is a common disease, imposing a great burden through pain and decreased function. There are many therapeutic modalities including non-pharmacologic choices and oral, topical, and intra-articular medications. New studies have shown promising results for ozone application in knee OA. Our aim was to compare the effects of ozone therapy versus hyaluronic acid (HA) intra-articular injection in knee OA patients. Methods: In this randomized clinical trial, a total of 174 patients with more than 3 months of chronic pain or swelling in the knee joints along with consistent imaging findings were enrolled and randomly allocated into two groups of HA and ozone, which were planned to undergo 3 weekly injections of HA (Hyalgan®) and 10 mL of a 30 μg/mL ozone solution, respectively...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29376822/suppression-and-facilitation-of-human-neural-responses
#18
Michael-Paul Schallmo, Alexander M Kale, Rachel Millin, Anastasia V Flevaris, Zoran Brkanac, Richard Ae Edden, Raphael A Bernier, Scott Murray
Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining 5 different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression and facilitation. We show that: 1) both suppression and facilitation can emerge from a single, computational principle - divisive normalization; there is no need to invoke separate neural mechanisms, 2) neural suppression and facilitation in the motion-selective area MT mirror perception, but strong suppression also occurs in earlier visual areas, and 3) suppression is not primarily driven by GABA-mediated inhibition...
January 29, 2018: ELife
https://www.readbyqxmd.com/read/29365005/recommendations-for-the-pharmacological-treatment-of-copd-questions-and-answers
#19
Frederico Leon Arrabal Fernandes, Alberto Cukier, Aquiles Assunção Camelier, Carlos Cezar Fritscher, Cláudia Henrique da Costa, Eanes Delgado Barros Pereira, Irma Godoy, José Eduardo Delfini Cançado, José Gustavo Romaldini, Jose Miguel Chatkin, José Roberto Jardim, Marcelo Fouad Rabahi, Maria Cecília Nieves Maiorano de Nucci, Maria da Penha Uchoa Sales, Maria Vera Cruz de Oliveira Castellano, Miguel Abidon Aidé, Paulo José Zimermann Teixeira, Renato Maciel, Ricardo de Amorim Corrêa, Roberto Stirbulov, Rodrigo Abensur Athanazio, Rodrigo Russo, Suzana Tanni Minamoto, Fernando Luiz Cavalcanti Lundgren
The treatment of COPD has become increasingly effective. Measures that range from behavioral changes, reduction in exposure to risk factors, education about the disease and its course, rehabilitation, oxygen therapy, management of comorbidities, and surgical and pharmacological treatments to end-of-life care allow health professionals to provide a personalized and effective therapy. The pharmacological treatment of COPD is one of the cornerstones of COPD management, and there have been many advances in this area in recent years...
July 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29364513/n-palmitoyl-ethanol-amide-pharmacological-treatment-in-patients-with-nonsurgical-lumbar-radiculopathy
#20
Domenico Chirchiglia, Saverio Paventi, Paolo Seminara, Erika Cione, Luca Gallelli
Palmitoyl ethanol amide (PEA) is an endogenous substance that plays a role in neuropathic pain. In this article, we evaluated both the safety and the efficacy of ultramicronized PEA (um-PEA) in the treatment of low back pain related to nonsurgical lumbar radiculopathy. In this prospective single-blind study, patients with low back pain related to nonsurgical lumbar radiculopathy received the fixed combination acetaminophen/codeine (500 mg + 30 mg/d) for 7 days, and then it was stopped and changed to um-PEA (1200 mg/d) for 30 days...
January 24, 2018: Journal of Clinical Pharmacology
keyword
keyword
88574
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"