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https://www.readbyqxmd.com/read/28931169/effect-of-educational-package-on-lifestyle-of-primiparous-mothers-during-postpartum-period-a-randomized-controlled-clinical-trial
#1
Farzaneh Khodabandeh, Mojgan Mirghafourvand, Mahin KamaliFard, Sakineh Mohammad-Alizadeh-Charandabi, Mohammad Asghari Jafarabadi
A healthy lifestyle is important for mothers during the postpartum period. This study was conducted to determine the effects of a lifestyle educational package in primiparous women. This randomized clinical trial was conducted on 220 mothers assigned to two groups using block randomization. In the intervention group, the mothers received face-to-face, phone and SMS counseling and a booklet in addition to routine postpartum training; in the control group, the mothers received only routine training. The Health Behaviors Questionnaire, a Food Frequency Questionnaire and the International Physical Activity Questionnaire were used for data collection...
October 1, 2017: Health Education Research
https://www.readbyqxmd.com/read/28931087/microbial-analysis-of-zetaproteobacteria-and-co-colonizers-of-iron-mats-in-the-troll-wall-vent-field-arctic-mid-ocean-ridge
#2
Jan Vander Roost, Ingunn Hindenes Thorseth, Håkon Dahle
Over the last decade it has become increasingly clear that Zetaproteobacteria are widespread in hydrothermal systems and that they contribute to the biogeochemical cycling of iron in these environments. However, how chemical factors control the distribution of Zetaproteobacteria and their co-occurring taxa remains elusive. Here we analysed iron mats from the Troll Wall Vent Field (TWVF) located at the Arctic Mid-Ocean Ridge (AMOR) in the Norwegian-Greenland Sea. The samples were taken at increasing distances from high-temperature venting chimneys towards areas with ultraslow low-temperature venting, encompassing a large variety in geochemical settings...
2017: PloS One
https://www.readbyqxmd.com/read/28931050/saxs-and-stability-studies-of-iron-induced-oligomers-of-bacterial-frataxin-cyay
#3
Mostafa Fekry, Wessen Alshokry, Przemysław Grela, Marek Tchórzewski, Eva-Christina Ahlgren, Christopher A Söderberg, Oleksandr Gakh, Grazia Isaya, Salam Al-Karadaghi
Frataxin is a highly conserved protein found in both prokaryotes and eukaryotes. It is involved in several central functions in cells, which include iron delivery to biochemical processes, such as heme synthesis, assembly of iron-sulfur clusters (ISC), storage of surplus iron in conditions of iron overload, and repair of ISC in aconitase. Frataxin from different organisms has been shown to undergo iron-dependent oligomerization. At least two different classes of oligomers, with different modes of oligomer packing and stabilization, have been identified...
2017: PloS One
https://www.readbyqxmd.com/read/28931034/primary-care-physicians-are-under-testing-for-celiac-disease-in-patients-with-iron-deficiency-anemia-results-of-a-national-survey
#4
Marisa Spencer, Adrienne Lenhart, Jason Baker, Joseph Dickens, Arlene Weissman, Andrew J Read, Seema Saini, Sameer D Saini
BACKGROUND: Iron deficiency anemia (IDA) is a common extra-intestinal manifestation of celiac disease (CD). Little is known about the frequency with which primary care physicians (PCPs) test for CD in patients with IDA. We aimed to describe how PCPs approach testing for CD in asymptomatic patients with IDA. METHODS: We electronically distributed a survey to PCPs who are members of the American College of Physicians. Respondents were asked whether they would test for CD (serologic testing, refer for esophagogastroduodenoscopy [EGD], or refer to GI) in hypothetical patients with new IDA, including: (1) a young Caucasian man, (2) a premenopausal Caucasian woman, (3) an elderly Caucasian man, and (4) a young African American man...
2017: PloS One
https://www.readbyqxmd.com/read/28930842/type-4b-hereditary-hemochromatosis-associated-with-a-novel-mutation-in-the-slc40a1-gene-a-case-report-and-a-review-of-the-literature
#5
Wei Zhang, Tingxia Lv, Jian Huang, Xiaojuan Ou
RATIONALE: Hereditary hemochromatosis can be divided into HFE- and non-HFE-related based on genetic mutations in different genes. HFE-related hemochromatosis is the most common inherited genetic disease in European populations but rare in Asia-pacific region. Recently, non-HFE-related hemochromatosis has been reported in patients from the Asian countries. PATIENT CONCERNS: We report the case of a 48-year-old Chinese Han woman who presented with abnormal liver function, diabetes mellitus, hyperferritinemia, and high transferrin saturation, with severe iron overload in parenchymal cells, Kupffer cells, and periportal fibrosis on liver biopsy...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930590/chelation-protocols-for-the-elimination-and-prevention-of-iron-overload-in-thalassaemia
#6
Annita Kolnagou, George John Kontoghiorghes
Iron overload toxicity is the main cause of mortality and morbidity in thalassaemia patients. The complete elimination and prevention of iron overload is the main aim of chelation therapy, which can be achieved by chelation protocols that can effectively remove excess iron load and maintain body iron at normal levels. Deferiprone and selected combinations with deferoxamine can be designed, adjusted and used effectively for removing all excess stored iron and for maintaining normal iron stores (NIS) in different categories of thalassaemia patients...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930516/new-targeted-therapies-and-diagnostic-methods-for-iron-overload-diseases
#7
Annita Kolnagou, Christina N Kontoghiorghe, George John Kontoghiorghes
Millions of people worldwide suffer from iron overload toxicity diseases such as transfusional iron overload in thalassaemia and hereditary haemochromatosis. The accumulation and presence of toxic focal iron deposits causing tissue damage can also be identified in Friedreich's ataxia, Alzheimer's, Parkinson's, renal and other diseases. Different diagnostic criteria of toxicity and therapeutic interventions apply to each disease of excess or misplaced iron. Magnetic resonance imaging relaxation times T2 and T2* for monitoring iron deposits in organs and iron biomarkers such as serum ferritin and transferrin iron saturation have contributed in the elucidation of iron toxicity mechanisms and pathways, and also the evaluation of the efficacy and mode of action of chelating drugs in the treatment of diseases related to iron overload, toxicity and metabolism...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28930448/direct-observation-of-oxygen-rebound-with-an-iron-hydroxide-complex
#8
Jan Paulo T Zaragoza, Timothy H Yosca, Maxime A Siegler, Pierre Moënne-Loccoz, Michael T Green, David P Goldberg
The rebound mechanism for alkane hydroxylation was invoked over 40 years ago to help explain reactivity patterns in cytochrome P450, and subsequently has been used to provide insight into a range of biological and synthetic systems. Efforts to model the rebound reaction in a synthetic system have been unsuccessful, in part because of the challenge in preparing a suitable metal-hydroxide complex at the correct oxidation level. Herein we report the synthesis of such a complex. The reaction of this species with a series of substituted radicals allows for the direct interrogation of the rebound process, providing insight into this uniformly invoked, but previously unobserved process...
September 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28930186/the-effect-of-copper-addition-on-the-activity-and-stability-of-iron-based-co%C3%A2-hydrogenation-catalysts
#9
Matthew J Bradley, Ramagopal Ananth, Heather D Willauer, Jeffrey W Baldwin, Dennis R Hardy, Frederick W Williams
Iron-based CO₂ catalysts have shown promise as a viable route to the production of olefins from CO₂ and H₂ gas. However, these catalysts can suffer from low conversion and high methane selectivity, as well as being particularly vulnerable to water produced during the reaction. In an effort to improve both the activity and durability of iron-based catalysts on an alumina support, copper (10-30%) has been added to the catalyst matrix. In this paper, the effects of copper addition on the catalyst activity and morphology are examined...
September 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28929923/rethinking-brain-cancer-therapy-tumor-enzyme-activatable-theranostic-nanoparticles
#10
Heike E Daldrup-Link
This invited commentary discusses a recent article by Mohanty et al in Molecular Cancer Therapeutics about significant therapeutic efficacies of novel theranostic nanoparticles (TNPs) for the treatment of human brain cancers in mouse models. The TNPs were cleaved by enzymes in the tumor tissue, matrix metalloproteinase (MMP-14), which lead to release of a highly potent therapeutic drug, azademethylcolchicine. Data showed that the TNPs caused selective toxic effects in MMP-14-expressing glioblastoma and not normal brain...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28929800/microcosm-investigation-of-growth-and-phytoremediation-potential-of-azolla-japonica-along-nitrogen-gradients
#11
Hun Park, Uhram Song
Although Azolla species are among the most promising plants for use in phytoremediation, more studies on their growth and nitrogen (N) uptake along the N gradients of growing media are required. In this study, N concentration-dependent growth in growing media and phosphorus (P) and N accumulation by Azolla japonica were studied by estimating direct N uptake from media by molybdenum-iron proteins. The doubling time of A. japonica was less than a week, regardless of the N concentration (0, 5, and 25 mg N/L) present in the growth media, indicating that this plant is suitable for remediation...
October 3, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28929623/influence-of-combined-iron-supplementation-and-simulated-hypoxia-on-the-haematological-module-of-the-athlete-biological-passport
#12
Laura A Garvican-Lewis, Victor L Vuong, Andrew D Govus, Yorck Olaf Schumacher, David Hughes, Greg Lovell, Daniel Eichner, Christopher J Gore
The integrity of Athlete Biological Passport (ABP) is underpinned by understanding normal fluctuations of its biomarkers to environmental or medical conditions, e.g. altitude training or iron deficiency. The combined impact of altitude and iron supplementation on the ABP was evaluated in endurance-trained athletes (n=34) undertaking 3-weeks of simulated live-high: train-low (14 h.d(-1) , 3000m). Athletes received either oral, intravenous (IV) or placebo iron supplementation, commencing two weeks prior and continuing throughout hypoxic exposure...
September 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28929548/an-fe-iii-aza-macrocyclic-complex-as-ph-tunable-catholyte-and-anolyte-for-redox-flow-battery-applications
#13
Pavel B Tsitovich, Anjula M Kosswattaarachchi, Matthew R Crawley, Timothy Y Tittiris, Timoth R Cook, Janet Ruth Morrow
A reversible Fe3+/Fe2+ redox couple of an aza-macrocyclic complex is evaluated as an electrolyte with a pH-tunable potential range for aqueous redox-flow batteries (RFBs). The Fe(III) complex is formed by 1,4,7-triazacyclononane (TACN) appended with three 2-methyl-imidazole donors, denoted as Fe(Tim). This complex exhibits pH-sensitive redox couples that span E1/2(Fe3+/Fe2+)=317 to -270 mV vs. NHE at pH 3.3 and pH 12.8, respectively. The 590 mV shift in potential and kinetic inertness are driven by ionization of the imidazoles at various pH values...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28929515/treatment-of-hepatitis-c-virus-infection-with-direct-acting-antiviral-drugs-is-safe-and-effective-in-patients-with-hemoglobinopathies
#14
Raffaella Origa, Maria Laura Ponti, Aldo Filosa, Alfonso Galeota Lanza, Antonio Piga, Giorgio Maria Saracco, Valeria Pinto, Antonino Picciotto, Paolo Rigano, Salvatore Madonia, Rosamaria Rosso, Domenico D'Ascola, Maria Domenica Cappellini, Roberta D'Ambrosio, Immacolata Tartaglione, Lucia De Franceschi, Barbara Gianesin, Vito Di Marco, Gian Luca Forni
Progression of liver fibrosis in patients with hemoglobinopathies is strongly related to the severity of iron overload and the presence of chronic hepatitis C virus (HCV) infection. Effective iron chelation therapy and HCV infection eradication may prevent liver complications. The European Association for the Study of the Liver guidelines recommend interferon-free regimens for the treatment of HCV infection in patients with hemoglobinopathies. However, data regarding the use of direct-acting antiviral drugs (DAAs) in this patient population are few...
September 20, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28929467/erratum-to-hfe-mrna-expression-is-responsive-to-intracellular-and-extracellular-iron-loading-short-communication
#15
Kosha J Mehta, Sebastien Farnaud, Vinood B Patel
The original article shows an error the co-author name: Sebastien Farnaud. The original article was corrected.
September 19, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28929355/post-treatment-method-for-the-synthesis-of-monodisperse-binary-fept-fe3o4-nanoparticles
#16
Zhilu Liu, Chun Wu, Liang Niu, Ganting Yang, Kai Wang, Wenli Pei, Qiang Wang
To obtain the optimal 1:1 composition of FePt alloy nanomaterials by polyol synthesis, the iron precursor (iron pentacarbonyl, Fe(CO)5) must be used in excess, because the Fe(CO)5 exists in the vapor phase at the typical temperatures used for FePt synthesis and cannot be consumed completely. Fabrication of Fe3O4 nanoparticles by consuming the excess iron precursor was an effective strategy to make full use of the iron precursor. In this paper, a facile post-treatment method was applied to consume the excess iron, which was oxidized to Fe3O4 after post-treatment at 150 and 200 °C, and a monodisperse binary FePt-Fe3O4 nanoparticle system was generated...
September 19, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28928729/high-throughput-genetic-screen-reveals-that-early-attachment-and-biofilm-formation-are-necessary-for-full-pyoverdine-production-by-pseudomonas-aeruginosa
#17
Donghoon Kang, Natalia V Kirienko
Pseudomonas aeruginosa is a re-emerging, multidrug-resistant, opportunistic pathogen that threatens the lives of immunocompromised patients, patients with cystic fibrosis, and those in critical care units. One of the most important virulence factors in this pathogen is the siderophore pyoverdine. Pyoverdine serves several critical roles during infection. Due to its extremely high affinity for ferric iron, pyoverdine gives the pathogen a significant advantage over the host in their competition for iron. In addition, pyoverdine can regulate the production of multiple bacterial virulence factors and perturb host mitochondrial homeostasis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28928531/recovery-from-dietary-iron-deficiency-anaemia-in-rats-by-the-intake-of-microencapsulated-ferric-saccharate
#18
Elisabet Lázaro, Jonathan Santas, Magda Rafecas
This study examined the bioavailability of iron contained in microencapsulated ferric saccharate in a rat model of iron deficiency anaemia. Three groups of male Sprague-Dawley rats with induced iron deficiency anaemia were subsequently treated with a control Fe-deficient diet (2-6 mg Fe/Kg of diet) with or without the addition of 10 mg Fe/Kg of diet (in form of ferrous sulphate or microencapsulated ferric saccharate) for 2 weeks. The bioavailability of microencapsulated ferric saccharate was examined by measuring body weight gain, feed efficiency and reticulocyte parameters, and compared with the bioavailability of ferrous sulphate...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28928514/component-analysis-of-nutritionally-rich-chloroplasts-recovery-from-conventional-and-unconventional-green-plant-species
#19
Mohamed A Gedi, Rhianna Briars, Felius Yuseli, Noorazwani Zainol, Randa Darwish, Andrew M Salter, David A Gray
A study of the literature indicates that chloroplasts synthesise a range of molecules, many of which have nutritional value for humans, but the nutritional credentials of chloroplasts recovered from plant cells are not established. Chloroplast-rich-fractions (CRFs) were prepared from green plant species and the macro- and micro-nutrient composition compared with the whole leaf materials (WLMs). The results indicated that, on a dry weight basis, CRF material from a range of green biomass was enriched in lipids and proteins, and in a range of micronutrients compared with the WLM...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28928510/co-extrusion-of-food-grains-banana-pulp-for-nutritious-snacks-optimization-of-process-variables
#20
D Mridula, Swati Sethi, Surya Tushir, Sheetal Bhadwal, R K Gupta, S K Nanda
Present study was undertaken to optimize the process conditions for development of food grains (maize, defatted soy flour, sesame seed)-banana based nutritious expanded snacks using extrusion processing. Experiments were designed using Box-Behnken design with banana pulp (8-24 g), screw speed (300-350 rpm) and feed moisture (14-16% w.b.). Seven responses viz. expansion ratio (ER), bulk density (BD), water absorption index (WAI), protein, minerals, iron and sensory acceptability were considered for optimizing independent parameters...
August 2017: Journal of Food Science and Technology
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