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serin protease inhibitor

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https://www.readbyqxmd.com/read/28427999/serpinb1-ameliorates-acute-lung-injury-in-liver-transplantation-through-erk1-2-mediated-stat3-dependent-ho-1-induction
#1
Weifeng Yao, Haobo Li, Gangjian Luo, Xiang Li, Chaojin Chen, Dongdong Yuan, Xinjin Chi, Zhengyuan Xia, Ziqing Hei
BACKGROUND: Postoperative acute lung injury(ALI) is a severe complication after liver transplantation, which severely affects postoperative patients' survival. The underlying mechanism is largely unknown and effective treatment limited. We explored the role of serpin protease inhibitor B1(SERPINB1), a potent inhibitor of neutrophil serine proteases, in ALI in liver transplantation and its interplay with signal transducer and activator of transcription 3(STAT3) and heme oxygenase-1(HO-1)...
April 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28424376/serpinc1-antithrombin-iii-in-kidney-related-diseases
#2
REVIEW
Zeyuan Lu, Feng Wang, Mingyu Liang
The gene SerpinC1 encodes a serine protease inhibitor named antithrombin III (ATIII). This protease demonstrates both anticoagulant and anti-inflammatory action. ATIII is the most important coagulation factor inhibitor, and even minor changes in ATIII can significantly alter the risk of thromboembolism. ATIII can also suppress inflammation via a coagulation-dependent or -independent effect. Moreover, apart from ATIII deficiency, ATIII and its gene SerpinC1 may also be related to many diseases (e.g. hypertension, kidney diseases)...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28417942/protein-discovery-combined-transcriptomic-and-proteomic-analyses-of-venom-from-the-endoparasitoid-cotesia-chilonis-hymenoptera-braconidae
#3
Zi-Wen Teng, Shi-Jiao Xiong, Gang Xu, Shi-Yu Gan, Xuan Chen, David Stanley, Zhi-Chao Yan, Gong-Yin Ye, Qi Fang
Many species of endoparasitoid wasps provide biological control services in agroecosystems. Although there is a great deal of information on the ecology and physiology of host/parasitoid interactions, relatively little is known about the protein composition of venom and how specific venom proteins influence physiological systems within host insects. This is a crucial gap in our knowledge because venom proteins act in modulating host physiology in ways that favor parasitoid development. Here, we identified 37 possible venom proteins from the polydnavirus-carrying endoparasitoid Cotesia chilonis by combining transcriptomic and proteomic analyses...
April 12, 2017: Toxins
https://www.readbyqxmd.com/read/28414992/airway-proteases-an-emerging-drug-target-for-influenza-and-other-respiratory-virus-infections
#4
REVIEW
Manon Laporte, Lieve Naesens
To enter into airway epithelial cells, influenza, parainfluenza- and coronaviruses rely on host cell proteases for activation of the viral protein involved in membrane fusion. One protease, transmembrane protease serine 2 (TMPRSS2) was recently proven to be crucial for hemagglutinin cleavage of some human influenza viruses. Since the catalytic sites of the diverse serine proteases linked to influenza, parainfluenza- and coronavirus activation are structurally similar, active site inhibitors of these airway proteases could have broad therapeutic applicability against multiple respiratory viruses...
April 14, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28411181/monoclonal-antibodies-to-the-reactive-centre-loop-rcl-of-human-corticosteroid-binding-globulin-cbg-can-protect-against-proteolytic-cleavage
#5
John G Lewis, Peter A Elder
Corticosteroid-binding globulin (CBG) binds most of the cortisol in circulation and is a non-functional member of the family of serine protease inhibitors (serpins) with an exposed elastase sensitive reactive centre loop (RCL). The RCL can be cleaved by human neutrophil elastase, released from activated neutrophils, and can also be cleaved at nearby site(s) by elastase released by Pseudomonas aeruginosa, and at two further sites, also within the RCL, by bovine chymotrypsin. Cleavage of the RCL results in a conformational change accompanied by a marked decrease in affinity for cortisol and hence its release at the site of proteolysis...
April 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28410411/hepatitis-c-virus-impairs-natural-killer-cell-activity-via-viral-serine-protease-ns3
#6
Chang Mo Yang, Joo Chun Yoon, Jeon Han Park, Jae Myun Lee
Hepatitis C virus (HCV) infection is characterized by a high frequency of chronic cases owing to the impairment of innate and adaptive immune responses. The modulation of natural killer (NK) cell functions by HCV leads to an impaired innate immune response. However, the underling mechanisms and roles of HCV proteins in this immune evasion are controversial, especially in the early phase of HCV infection. To investigate the role of HCV nonstructural proteins especially NS3 in the impairment of NK functions, NK cells were isolated from the PBMCs by negative selection...
2017: PloS One
https://www.readbyqxmd.com/read/28406338/increased-kallistatin-levels-in-patients-with-obesity-and-prediabetes-compared-to-normal-glucose-tolerance
#7
Antoaneta Gateva, Yavor Assyov, Tsvetelina Velikova, Zdravko Kamenov
PURPOSE: Kallistatin is a member of serine protease inhibitors (SERPIN) family, which has various functions such as regulation of cardiovascular function and blood vessels development. Its levels are elevated in patients with type 1 and type 2 diabetes with chronic diabetic complications. The aim of the present study was to compare serum kallistatin levels between obese subjects with prediabetes and with normal glucose tolerance. METHODS: In this study we included 80 subjects at mean age of 50...
May 2017: Endocrine Research
https://www.readbyqxmd.com/read/28406289/phylogenomic-analysis-of-the-microviridin-biosynthetic-pathway-coupled-with-targeted-chemoenzymatic-synthesis-yields-potent-protease-inhibitors
#8
Muhammad N Ahmed, Emmanuel Reyna González, Bianca Schmid, Vincent Wiebach, Roderich Suessmuth, Elke Dittmann, David P Fewer
Natural products and their semi-synthetic derivatives are an important source of drugs for the pharmaceutical industry. Bacteria are prolific producers of natural products and encode a vast diversity of natural product biosynthetic gene clusters. However, much of this diversity is inaccessible to natural product discovery. Here we use a combination of phylogenomic analysis of the microviridin biosynthetic pathway and chemo-enzymatic synthesis of bioinformatically predicted microviridins to yield new protease inhibitors...
April 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28405681/maspin-suppresses-growth-proliferation-and-invasion-in-cutaneous-squamous-cell-carcinoma-cells
#9
Hong Zhu, Qing Mao, Weiwei Liu, Zhenhai Yang, Xiaoqing Jian, Le Qu, Chundi He
Cutaneous squamous cell carcinoma (cSCC) is a common malignant tumor. Mammary serine protease inhibitor (Maspin), a member of serpin family, has been reported as a tumor suppressor in various carcinomas. In this study, we detected the expression level of Maspin in cSCC tissues by real-time PCR and western blotting, and found that Maspin was downregulated in the cSCC tissues compared with the adjacent normal tissues. Moreover, Maspin was stably overexpressed in A431 cells, and CCK-8 assay, colony formation assay, Transwell assay, Hoechst staining and western blotting were carried out to detect the growth, proliferation, invasion, cell cycle and apoptosis of A431 cells...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28402100/structural-studies-revealed-active-site-distortions-of-human-furin-by-a-small-molecule-inhibitor
#10
Sven O Dahms, Guan-Sheng Jiao, Manuel E Than
Proprotein Convertases (PCs) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage. Their inhibition is a promising strategy for the treatment of several pathologies including cancer, atherosclerosis, hypercholesterolaemia, and infectious diseases. Here we present the first experimental complex of furin with a non substrate-like small molecule inhibitor, and the X-ray structure of the enzyme complexed to the small molecule inhibitor 1 at 1.9 Å resolution. Two molecules of inhibitor 1 were found to interact with furin...
April 12, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28394881/impact-of-ulinastatin-on-outcomes-in-acute-burns-patients
#11
S V Abhyankar, A M Vartak
Burns is a global health problem with significant morbidity and mortality. Ulinastatin, a serine protease inhibitor, has the potential to improve outcomes in burns. A retrospective comparative case note review analysis was performed to assess the impact of ulinastatin on the outcomes in acute burns patients. Acute burns patients, admitted to Masina hospital, Mumbai, from October 2012 to April 2015, who received ulinastatin, were identified from the hospital records. A similarly sized cohort of patients, admitted before the introduction of ulinastatin, was also identified...
April 3, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28387417/microscale-coiling-in-bis-imidazolium-supramolecular-hydrogel-fibres-induced-by-the-release-of-a-cationic-serine-protease-inhibitor
#12
David Limón, Claire Jiménez-Newman, Ana C Calpena, Arántzazu González-Campo, David B Amabilino, Lluïsa Pérez-García
Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.
April 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28374503/tryptase-potentiates-enteric-nerve-activation-by-histamine-and-serotonin-relevance-for-the-effects-of-mucosal-biopsy-supernatants-from-irritable-bowel-syndrome-patients
#13
D Ostertag, A Annahazi, D Krueger, K Michel, I E Demir, G O Ceyhan, F Zeller, M Schemann
BACKGROUND: We previously showed that mucosal biopsy supernatants from irritable bowel syndrome patients activated neurons despite low concentrations of tryptase, histamine, and serotonin which individually would not cause spike discharge. We studied the potentiating responses between these mediators on excitability of enteric neurons. METHODS: Calcium-imaging was performed using the calcium-sensitive dye Fluo-4 AM in human submucous plexus preparations from 45 individuals...
April 4, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28368394/inhibition-of-cyclooxygenase-2-mediated-matriptase-activation-contributes-to-the-suppression-of-prostate-cancer-cell-motility-and-metastasis
#14
C-J Ko, S-W Lan, Y-C Lu, T-S Cheng, P-F Lai, C-H Tsai, T-W Hsu, H-Y Lin, H-Y Shyu, S-R Wu, H-H Lin, P-W Hsiao, C-H Chen, H-P Huang, M-S Lee
Chronic inflammation plays an important role in cancer development and progression. Cyclooxygenases-2 (COX-2) is a key enzyme in generating prostaglandins causing inflammation, is often found to be overexpressed in prostate cancer (PCa) and is correlated with PCa cell invasion and metastasis. We aim to investigate the molecular mechanism of how COX-2 promotes PCa cell invasion and metastasis and to evaluate the effect of COX-2 inhibitors in a selected model of PCa progression. Our results showed that the expression of COX-2 and Interleukin 1β (IL-1β) was upregulated in highly invasive PCa cells and was correlated with the activated levels of membrane-anchored serine protease matriptase...
April 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28366787/manduca-sexta-hemolymph-protease-1-activated-by%C3%A2-an%C3%A2-unconventional-non-proteolytic-mechanism-mediates%C3%A2-immune%C3%A2-responses
#15
Yan He, Yang Wang, Fan Yang, Haobo Jiang
Tissue damage or pathogen invasion triggers the auto-proteolysis of an initiating serine protease (SP), rapidly leading to sequential cleavage activation of other cascade members to set off innate immune responses in insects. Recently, we presented evidence that Manduca sexta hemolymph protease-1 zymogen (proHP1) is a member of the SP system in this species, and may activate proHP6. HP6 stimulates melanization and induces antimicrobial peptide synthesis. Here we report that proHP1 adopts an active conformation (*) to carry out its function, without a requirement for proteolytic activation...
March 31, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28363953/avathrin-a-novel-thrombin-inhibitor-derived-from-a-multi-copy-precursor-in-the-salivary-glands-of-the-ixodid-tick-amblyomma-variegatum
#16
Janaki Krishnamoorthy Iyer, Cho Yeow Koh, Maria Kazimirova, Ladislav Roller, Chacko Jobichen, Kunchithapadam Swaminathan, Jun Mizuguchi, Sadaaki Iwanaga, Patricia A Nuttall, Mark Y Chan, R Manjunatha Kini
Tick saliva is a rich source of antihemostatic compounds. We amplified a cDNA from the salivary glands of the tropical bont tick (Amblyomma variegatum) using primers based on the variegin sequence, which we previously identified as a novel thrombin inhibitor from the same tick species. The transcript encodes a precursor protein comprising a signal peptide and 5 repeats of variegin-like sequences that could be processed into multiple short peptides. These peptides share 31 to 34% identity with variegin. Here, we structurally and functionally characterized one of these peptides named "avathrin...
March 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28362108/alpha1-antitrypsin-deficient-macrophages-have-increased-matriptase-mediated-proteolytic-activity
#17
Karina Krotova, George W Marek, Rejean L Wang, George Aslanidi, Brad E Hoffman, Nazli Khodayari, Farshid N Rouhani, Mark L Brantly
Alpha1-antitrypsin (AAT) deficiency-associated emphysema is largely attributed to insufficient inhibition of neutrophil elastase released from neutrophils. Correcting AAT levels by augmentation therapy only slows disease progression; the absence of full recovery indicates a more complex process of lung destruction. Because alveolar macrophages (Mɸ) express AAT, we propose that the expression and intracellular accumulation of mutated Z-AAT (the most common mutation is called Z) compromise Mɸ function and contribute to emphysema development...
March 31, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28360893/diversity-of-cultivable-protease-producing-bacteria-in-laizhou-bay-sediments-bohai-sea-china
#18
Yan Li, Chaoya Wu, Mingyang Zhou, En Tao Wang, Zhenpeng Zhang, Wei Liu, Jicai Ning, Zhihong Xie
Protease-producing bacteria are widespread in ocean sediments and play important roles in degrading sedimentary nitrogenous organic materials. However, the diversity of the bacteria and the proteases involved in such processes remain largely unknown especially for communities in enclosed sea bays. Here, we investigated the diversity of the extracellular protease-producing bacteria and their protease types in Laizhou Bay. A total of 121 bacterial isolates were obtained from sediment samples in 7 sites and their protease types were characterized...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28358031/serine-protease-sp105-activates-prophenoloxidase-in-asian-corn-borer-melanization-and-is-regulated-by-serpin-3
#19
Yuan Chu, Fang Hong, Qizhi Liu, Chunju An
Melanization reaction, resulting from the activation of prophenoloxidase, is a vital immune response in insects for encapsulating and killing the invasive organisms. Prophenoloxidase needs to be proteolytically activated by its upstream prophenoloxidase-activating protease (PAP) in melanization. Identification and characterization of PAPs facilitates the understanding of the molecular mechanisms involved in insect immunity. We here cloned a full-length cDNA for a serine protease, named as SP105, from Asian corn borer, Ostrinia furnacalis (Guenée)...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28356487/a-structural-and-functional-analogue-of-a-bowman-birk-type-protease-inhibitor-from-odorranaschmackeri
#20
Yuxin Wu, Qilin Long, Ying Xu, Shaodong Guo, Tianbao Chen, Lei Wang, Mei Zhou, Yingqi Zhang, Chris Shaw, Brian Walker
Frog skin secretions contain complex peptidomes and peptidic protease inhibitors are one of the biologically- and structurally-described groups of components. In this study, by use of molecular "shotgun" cloning and LC MS/MS fractionation sequencing, a novel Bowman Birk-type heptadecapeptide (AALKGCWTKSIPPKPCF-amide), named OSTI, with a canonical Cys(6)-Cys(16) disulfide bridge, was isolated and identified in Piebald Odorous Frog ( Odorrana schmackeri ) skin secretion. A synthetic replicate of OSTI exhibited trypsin inhibitory activity with a Ki value of 0...
March 29, 2017: Bioscience Reports
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