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"Multiple Chemical Sensitivities"

Alessandro Micarelli, Andrea Viziano, Giuseppe Genovesi, Ernesto Bruno, Fabrizio Ottaviani, Marco Alessandrini
Multiple chemical sensitivity (MCS) is a chronic disorder characterized by a variety of symptoms associated with the exposure to chemicals at a concentration below the toxic level. Previous studies have demonstrated peculiar responses in brain activity in these patients with respect to sensory stimuli while the association between chemical sensitivity and other environmental intolerances such as noise sensitivity has been questioned by researchers. In this study, a cohort of 18 MCS patients underwent transient-evoked otoacoustic emission (TEOAE) testing with and without contralateral suppression to evaluate the functionality of the medial olivocochlear (MOC) reflex involved in speech-in-noise sensitivity...
May 2016: Noise & Health
Pamela Reed Gibson, Sharon D Lockaby, Jenna Michele Bryant
In this paper, we summarize the results of an online survey of persons in the United States with chemical intolerance/multiple chemical sensitivity who sought help from mental health providers, including counselors, psychologists, psychiatrists, and others. Respondents reported on their most recent contact with a provider, describing reasons for the contact, accommodations requested and received, and suggestions for how the experience could be more helpful. Overall, though clients were accommodated in small ways, some received no accommodation, and many felt that the providers needed to be more knowledgeable regarding chemical intolerance...
2016: Journal of Multidisciplinary Healthcare
Takahiko Katoh, Yuki Fujiwara, Chihiro Nakashita, Xi Lu, Aya Hisada, Wataru Miyazaki, Kenichi Azuma, Mari Tanigawa, Iwao Uchiyama, Naoki Kunugita
Multiple chemical sensitivity (MCS) is an acquired chronic disorder characterized by nonspecific symptoms in multiple organ systems associated with exposure to low-level chemicals. Diagnosis of MCS can be difficult because of the inability to assess the causal relationship between exposure and symptoms. No standardized objective measures for the identification of MCS and no precise definition of this disorder have been established. Recent technological advances in mass spectrometry have significantly improved our capacity to obtain more data from each biological sample...
2016: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
V Pasta, V D'Orazi, L Ruggeri, M F Toni, P Urciuoli, G Tellan
Clinical practice sometimes brings to face with situations quite peculiar, potentially dangerous for the patient's life. In the great majority of cases, pathologies associated with each other (cardiovascular, respiratory, neurological), while in other cases we can treat rare diseases or syndromes. It's considered exceptional the simultaneous presence of "rare" pathologies in a single patient. This exceptionality has been a push to treat a patient as a "unique" asking for help to deeper studies of pharmacogenetics...
July 2015: Il Giornale di Chirurgia
Eva Lago Blanco, Jordi Puiguriguer Ferrando, Mónica Rodríguez Enríquez, Laura Agüero Gento, Joan Salvà Coll, Maria Rosa Pizà Portell
INTRODUCTION AND OBJECTIVE: Multiple chemical sensitivity (MCS) is a multisystem disorder of controversial etiology, affecting some subjects when exposed to chemicals at no harmful concentrations. The objective of this paper is to describe the epidemiological, clinical and psychological features of a sample of patients with MCS for further specific group treatment. PATIENS AND METHOD: Descriptive study of patients diagnosed with MCS in a toxicology unit. We administered the Quick Environmental Exposure and Sensitivity Inventory, the structured interview SCID-II, the anxiety scale HAS and the type A personality test, PCTA...
February 5, 2016: Medicina Clínica
Dominique Belpomme, Christine Campagnac, Philippe Irigaray
Much of the controversy over the causes of electro-hypersensitivity (EHS) and multiple chemical sensitivity (MCS) lies in the absence of both recognized clinical criteria and objective biomarkers for widely accepted diagnosis. Since 2009, we have prospectively investigated, clinically and biologically, 1216 consecutive EHS and/or MCS-self reporting cases, in an attempt to answer both questions. We report here our preliminary data, based on 727 evaluable of 839 enrolled cases: 521 (71.6%) were diagnosed with EHS, 52 (7...
2015: Reviews on Environmental Health
Thomas Meinertz Dantoft, Sine Skovbjerg, Linus Andersson, Anna-Sara Claeson, Nina Lind, Steven Nordin, Susanne Brix
BACKGROUND: Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances. Recent findings suggests that dysregulation of the immune system may play a role in MCS pathophysiology. OBJECTIVES: The aim of this study was to examine baseline and low dose n-butanol-induced upper airway inflammatory response profiles in MCS subjects versus healthy controls. METHOD: Eighteen participants with MCS and 18 age- and sex-matched healthy controls were enrolled in the study...
2015: PloS One
Zindel V Segal, Kathleen M Walsh
PURPOSE OF REVIEW: The article reviews the recent evidence for mindfulness-based cognitive therapy (MBCT) for patients with residual depressive symptoms or in remitted patients at increased risk for relapse. RECENT FINDINGS: Randomized controlled trials have shifted focus from comparing MBCT with treatment-as-usual to comparing MBCT against interventions. These studies have provided evidence for the efficacy of MBCT on par with maintenance antidepressant pharmacotherapy and leading to a relative reduction of risk on the order of 30-40%...
January 2016: Current Opinion in Psychiatry
Atsushi Mizukoshi, Kazukiyo Kumagai, Naomichi Yamamoto, Miyuki Noguchi, Kazuhiro Yoshiuchi, Hiroaki Kumano, Kou Sakabe, Yukio Yanagisawa
In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight multiple chemical sensitivity (MCS) patients using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, HF (high frequency), and LF (low frequency) to HF ratio compared with previous data from healthy subjects (Int...
October 2015: International Journal of Environmental Research and Public Health
Marco Alessandrini, Alessandro Micarelli, Agostino Chiaravalloti, Ernesto Bruno, Roberta Danieli, Mariangela Pierantozzi, Giuseppe Genovesi, Johanna Öberg, Marco Pagani, Orazio Schillaci
Multiple chemical sensitivity (MCS) patients usually react to odour compounds and the majority of neuroimaging studies assessed, especially at the cortical level, many olfactory-related correlates. The purpose of the present study was to depict sub-cortical metabolic changes during a neutral (NC) and pure (OC) olfactory stimulation by using a recently validated (18)F-2-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computer tomography procedure in 26 MCS and 11 healthy (HC) resting subjects undergoing a battery of clinical tests...
March 2016: Brain Topography
Cindy Sage
The 'informational content' of Earth's electromagnetic signaling is like a set of operating instructions for human life. These environmental cues are dynamic and involve exquisitely low inputs (intensities) of critical frequencies with which all life on Earth evolved. Circadian and other temporal biological rhythms depend on these fluctuating electromagnetic inputs to direct gene expression, cell communication and metabolism, neural development, brainwave activity, neural synchrony, a diversity of immune functions, sleep and wake cycles, behavior and cognition...
2015: Reviews on Environmental Health
Ghan-Shyam Lohiya, Sapna Lohiya, Sunita Lohiya, Vijay Krishna
Background. Scombrotoxinism is an acute toxin-induced illness caused primarily by bacterial synthesis of histamine in decomposed fish. Case Report. Immediately after taking 2-3 bites of cooked salmon, a clerical worker developed oral burning, urticaria, and asthma. In the emergency department, she was diagnosed with "allergies"; scombrotoxinism was never considered. She then developed wide-ranging symptoms (e.g., chronic fatigue, asthma, anxiety, multiple chemical sensitivity, and paresthesiae) and saw many specialists (in pulmonology, otorhinolaryngology, allergy, toxicology, neurology, psychology, and immunology)...
2015: Case Reports in Emergency Medicine
Christian Riise Hauge, Alice Rasmussen, Jacob Piet, Jens Peter Bonde, Claus Jensen, Antonia Sumbundu, Sine Skovbjerg
OBJECTIVE: Multiple chemical sensitivity (MCS) is a medically unexplained condition characterized by symptoms from multiple organ systems following the perception of common odorants. The condition can cause severe functional impairment for afflicted individuals. The aim of this study was to assess the effects of mindfulness-based cognitive therapy (MBCT) for individuals with MCS. METHODS: The intention-to-treat sample (ITT) included 69 individuals who had been randomized to either MBCT or treatment as usual (TAU)...
December 2015: Journal of Psychosomatic Research
Raúl Jesús Regal Ramos
No abstract text is available yet for this article.
October 2015: Semergen
Thomas M Dantoft, Linus Andersson, Steven Nordin, Sine Skovbjerg
Chemical intolerance (CI) is a term used to describe a condition in which the sufferer experiences a complex array of recurrent unspecific symptoms attributed to low-level chemical exposure that most people regard as unproblematic. Severe CI constitutes the distinguishing feature of multiple chemical sensitivity (MCS). The symptoms reported by CI subjects are manifold, involving symptoms from multiple organs systems. In severe cases of CI, the condition can cause considerable life-style limitations with severe social, occupational and economic consequences...
2015: Current Rheumatology Reviews
Linus Andersson, Anna-Sara Claeson, Thomas Meinertz Dantoft, Sine Skovbjerg, Nina Lind, Steven Nordin
PURPOSE: Multiple chemical sensitivity (MCS) is a prevalent medically unexplained symptom characterized by symptom reactions to everyday chemical exposure below hygienic thresholds. The aim of this study was to investigate the expressions of hyper-reactivity in MCS during whole-body exposure to low concentrations of the odorant n-butanol. METHODS: We exposed 18 participants with MCS and 18 non-ill controls to a low concentration of the odorant n-butanol using an exposure chamber...
January 2016: International Archives of Occupational and Environmental Health
Chiara De Luca, Agnese Gugliandolo, Carlo Calabrò, Monica Currò, Riccardo Ientile, Desanka Raskovic, Ludmila Korkina, Daniela Caccamo
Oxidative stress and inflammation play a pathogenetic role in idiopathic environmental intolerances (IEI), namely, multiple chemical sensitivity (MCS), fibromyalgia (FM), and chronic fatigue syndrome (CFS). Given the reported association of nitric oxide synthase (NOS) gene polymorphisms with inflammatory disorders, we aimed to investigate the distribution of NOS2A -2.5 kb (CCTTT) n as well as Ser608Leu and NOS3 -786T>C variants and their correlation with nitrite/nitrate levels, in a study cohort including 170 MCS, 108 suspected MCS (SMCS), 89 FM/CFS, and 196 healthy subjects...
2015: Mediators of Inflammation
Sine Skovbjerg, Karl Bang Christensen, Jeanette Frost Ebstrup, Allan Linneberg, Robert Zachariae, Jesper Elberling
OBJECTIVE: Chemical intolerance (CI) is characterised by negative health effects attributed to a heightened responsiveness to common airborne chemicals. This longitudinal study explored the hypothesised role of negative affect in the development and persistence of CI in a general population. METHODS: A general population sample aged 19 to 72 years was examined in 2006-2008 and again in 2011-2012. Longitudinal data on CI were analysed with the purpose of examining baseline negative affect as a risk factor for having developed CI at 5-year follow-up and for reporting persistent CI...
May 2015: Journal of Psychosomatic Research
Agostino Chiaravalloti, Marco Pagani, Alessandro Micarelli, Barbara Di Pietro, Giuseppe Genovesi, Marco Alessandrini, Orazio Schillaci
PURPOSE: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals. METHODS: Two (18)F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS)...
April 2015: European Journal of Nuclear Medicine and Molecular Imaging
Kenichi Azuma, Iwao Uchiyama, Mari Tanigawa, Ikuko Bamba, Michiyo Azuma, Hirohisa Takano, Toshikazu Yoshikawa, Kou Sakabe
OBJECTIVES: Multiple chemical sensitivity (MCS) is a chronic acquired disorder characterized by non-specific symptoms in multiple organ systems associated with exposure to odorous chemicals. We previously observed significant activations in the prefrontal cortex (PFC) during olfactory stimulation using several different odorants in patients with MCS by near-infrared spectroscopy (NIRS) imaging. We also observed that the patients with MCS did not adequately distinguish non-odorant in the late stage of the repeated olfactory stimulation test...
May 2015: Environmental Health and Preventive Medicine
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