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https://www.readbyqxmd.com/read/29778021/the-homing-of-human-umbilical-cord-derived-mesenchymal-stem-cells-and-the-subsequent-modulation-of-macrophage-polarization-in-type-2-diabetic-mice
#1
Yaqi Yin, Haojie Hao, Yu Cheng, Jieqing Gao, Jiejie Liu, Zongyan Xie, Qi Zhang, Li Zang, Weidong Han, Yiming Mu
Umbilical cord-derived mesenchymal stem cells (UC-MSCs), with both immunomodulatory and pro-regenerative properties, are promising for the treatment of type 2 diabetes mellitus (T2DM). As efficient cell therapy largely relies on appropriate homing to target tissues, knowing where and to what extent injected UC-MSCs have homed is critically important. However, bio-distribution data for UC-MSCs in T2DM subjects are extremely limited. Beneficial effects of UC-MSCs on T2DM subjects are associated with increased M2 macrophages, but no systemic evaluation of M2 macrophages has been performed in T2DM individuals...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29775645/mesenchymal-stromal-cells-induce-a-permissive-state-in-the-bone-marrow-that-enhances-g-csf-induced-hematopoietic-stem-cell-mobilization-in-mice
#2
Evert-Jan F M de Kruijf, Rob Zuijderduijn, Marjolein C Stip, Willem E Fibbe, Melissa van Pel
Mesenchymal stromal cells (MSC) support hematopoietic stem cells (HSC) in vivo and enhance HSC engraftment and hematopoietic recovery upon co-transplantation with HSC. These data have led to the hypothesis that MSC may impact the HSC niche, leading to changes in HSC retention and trafficking. We studied the effect of MSC administration on the HSC compartment in the bone marrow (BM) in mice. Following injection of MSC, HSC numbers in the BM were decreased coinciding with an increased cell cycle activity compared to PBS-injected controls...
May 15, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29774072/twist-promotes-tumor-metastasis-in-basal-like-breast-cancer-by-transcriptionally-upregulating-ror1
#3
Jingying Cao, Xin Wang, Tao Dai, Yuanzhong Wu, Meifang Zhang, Renxian Cao, Ruhua Zhang, Gang Wang, Rou Jiang, Binhua P Zhou, Jian Shi, Tiebang Kang
Rationale: Twist is a key transcription factor for induction of epithelial-mesenchymal transition (EMT), which promotes cell migration, invasion, and cancer metastasis, confers cancer cells with stem cell-like characteristics, and provides therapeutic resistance. However, the functional roles and targeted genes of Twist in EMT and cancer progression remain elusive. Methods: The potential targeted genes of Twist were identified from the global transcriptomes of T47D/Twist cells by microarray analysis. EMT phenotype was detected by western blotting and immunofluorescence of marker proteins...
2018: Theranostics
https://www.readbyqxmd.com/read/29773298/veno-venous-extracorporeal-membrane-oxygenation-bridged-living-donor-lung-transplantation-for-rapid-progressive-respiratory-failure-with-pleuroparenchymal-fibroelastosis-after-allogeneic-hematopoietic-stem-cell-transplantation
#4
Ayako Shimada, Jiro Terada, Kenji Tsushima, Yoshihisa Tateishi, Ryuzo Abe, Shigeto Oda, Motomu Kobayashi, Masaomi Yamane, Takahiro Oto, Koichiro Tatsumi
Cases of extracorporeal membrane oxygenation (ECMO) bridged lung transplantation (LTx) are rare in Japan because an allocation system to prioritize patients based on urgency remains to be established. For critically ill patients who cannot wait for a brain-dead donor LTx, ECMO bridge to living-donor LTx may be the only practical option. A 21-year-old woman with pleuroparenchymal fibroelastosis after hematopoietic stem cell transplantation was admitted to our hospital with rapidly progressive respiratory failure...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29772675/silencing-stem-cell-factor-gene-in-fibroblasts-to-regulate-paracrine-factor-productions-and-enhance-c-kit-expression-in-melanocytes-on-melanogenesis
#5
Pin-Hui Li, Li-Heng Liu, Cheng-Chung Chang, Rong Gao, Chung-Hang Leung, Dik-Lung Ma, Hui-Min David Wang
Melanogenesis is a complex physiological mechanism involving various paracrine factors. Skin cells such as keratinocytes, fibroblasts, and melanocytes communicate with one another through secreted regulators, thereby regulating the melanocytes' bio-functions. The stem cell factor (SCF) is a paracrine factor produced by fibroblasts, and its receptor, c-kit, is expressed on melanocytes. Binding of SCF to c-kit activates autophosphorylation and tyrosine kinase to switch on its signal transmission. SCF inhibition does not suppress fibroblast proliferation in MTT assay, and SCF silencing induced mRNA expressions of paracrine factor genes, HGF , NRG-1 , and CRH in qPCR results...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29769669/diverse-mechanisms-for-endogenous-regeneration-and-repair-in-mammalian-organs
#6
REVIEW
James M Wells, Fiona M Watt
Mammalian organs comprise an extraordinary diversity of cell and tissue types. Regenerative organs, such as the skin and gastrointestinal tract, use resident stem cells to maintain tissue function. Organs with a lower cellular turnover, such as the liver and lungs, mostly rely on proliferation of committed progenitor cells. In many organs, injury reveals the plasticity of both resident stem cells and differentiated cells. The ability of resident cells to maintain and repair organs diminishes with age, whereas, paradoxically, the risk of cancer increases...
May 2018: Nature
https://www.readbyqxmd.com/read/29765429/the-potentials-and-caveats-of-mesenchymal-stromal-cell-based-therapies-in-the-preterm-infant
#7
REVIEW
Judith Gronbach, Tayyab Shahzad, Sarah Radajewski, Cho-Ming Chao, Saverio Bellusci, Rory E Morty, Tobias Reicherzer, Harald Ehrhardt
Preponderance of proinflammatory signals is a characteristic feature of all acute and resulting long-term morbidities of the preterm infant. The proinflammatory actions are best characterized for bronchopulmonary dysplasia (BPD) which is the chronic lung disease of the preterm infant with lifelong restrictions of pulmonary function and severe consequences for psychomotor development and quality of life. Besides BPD, the immature brain, eye, and gut are also exposed to inflammatory injuries provoked by infection, mechanical ventilation, and oxygen toxicity...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765324/evodiamine-a-novel-notch3-methylation-stimulator-significantly-suppresses-lung-carcinogenesis-in-vitro-and-in-vivo
#8
Tao Su, Xia Yang, Jian-Hua Deng, Qiu-Ju Huang, Su-Chao Huang, Yan-Min Zhang, Hong-Ming Zheng, Ying Wang, Lin-Lin Lu, Zhong-Qiu Liu
Lung cancer is a leading cause of cancer-related deaths worldwide. NOTCH3 signaling is mainly expressed in non-small cell lung carcinoma (NSCLC), and has been proposed as a therapeutic target of NSCLC. While, few agents for preventing or treating NSCLC via targeting NOTCH3 signaling are used in modern clinical practice. Evodiamine (EVO), an alkaloid derived from Euodiae Fructus, possesses low toxicity and has long been shown to exert anti-lung cancer activity. However, the underlying anti-lung cancer mechanisms of EVO are not yet fully understood...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29764866/lrrc15-is-a-novel-mesenchymal-protein-and-stromal-target-for-antibody-drug-conjugates
#9
James W Purcell, Sonia G Tanlimco, Jonathan A Hickson, Melvin Fox, Mien Sho, Lisa Durkin, Tamar Uziel, Rick Powers, Kelly D Foster-Duke, Thomas McGonigal, Subashri Kumar, Josue Samayoa, Dong Zhang, Joann P Palma, Sasmita Mishra, Diane Hollenbaugh, Kurt Gish, Susan E Morgan-Lappe, Eric D Hsi, Debra T Chao
Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell type-specific protein markers. Using RNA expression profiling, we identified the membrane protein leucine rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29764837/il22-promotes-kras-mutant-lung-cancer-by-induction-of-a-pro-tumor-immune-response-and-protection-of-stemness-properties
#10
Nasim Khosravi, Mauricio S Caetano, Amber M Cumpian, Nese Unver, Cynthia De la Garza Ramos, Oscar Noble, Soudabeh Daliri, Belinda J Hernandez, Berenice A Gutierrez, Scott E Evans, Samir Hanash, Andrei M Alekseev, Yi Yang, Seon Hee Chang, Roza Nurieva, Humam Kadara, Jichao Chen, Edwin J Ostrin, Seyed Javad Moghaddam
Somatic KRAS mutations are the most common oncogenic variants in lung cancer and are associated with poor prognosis. Using a Kras-induced lung cancer mouse model, CC-LR, we previously showed a role for inflammation in lung tumorigenesis through activation of the NF-kB pathway, along with induction of interleukin 6 (IL6) and an IL17-producing CD4+ T-helper cell response. IL22 is an effector molecule secreted by CD4+ and γδ T cells that we previously found to be expressed in CC-LR mice. IL22 mostly signals through the STAT3 pathway and is thought to act exclusively on non-hematopoietic cells with basal IL22 receptor (IL22R) expression on epithelial cells...
May 15, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29760942/induction-of-chondrogenesis-of-human-placenta-derived-mesenchymal-stem-cells-via-heparin-grafted-human-fibroblast-derived-matrix
#11
Yong Kwan Noh, Ping Du, Avelino Dos Santos Da Costa, Kwideok Park
Background: Formation of mature and functional articular cartilage is still challenging in cartilage tissue engineering. This study investigates the potential of using heparin-grafted decellularized extracellular matrix (ECM) as a novel growth factor delivery platform towards human placenta-derived mesenchymal stem cells (hPMSCs) chondrogenic differentiation. Human fibroblast-derived extracellular matrix (hFDM) is naturally obtained from in vitro-cultured human lung fibroblasts via a mild decellularization process...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29760738/dental-mesenchymal-stem-stromal-cells-and-their-exosomes
#12
REVIEW
Peter Stanko, Ursula Altanerova, Jana Jakubechova, Vanda Repiska, Cestmir Altaner
Stem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. In this review, we intend to explore the properties of these cells with an emphasis on exosomes...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29756133/biology-of-teeth-and-implants-host-factors-pathology-regeneration-and-the-role-of-stem-cells
#13
F-Michael Eggert, Liran Levin
In chronic periodontitis and peri-implantitis, cells of the innate and adaptive immune systems are involved directly in the lesions within the tissues of the patient. Absence of a periodontal ligament around implants does not prevent a biologic process similar to that of periodontitis from affecting osseointegration. Our first focus is on factors in the biology of individuals that are responsible for the susceptibility of such individuals to chronic periodontitis and to peri-implantitis. Genetic factors are of significant importance in susceptibility to these diseases...
2018: Quintessence International
https://www.readbyqxmd.com/read/29755667/a-set-of-cancer-stem-cell-homing-peptides-associating-with-the-glycan-moieties-of-glycosphingolipids
#14
Yu-Hsiu Su, Tai-Yun Lin, Hung-Jen Liu, Chin-Kai Chuang
Cancer stem cells (CSCs) are currently believed to be involved in tumor metastasis and relapse. And treatments against CSCs are well concerned issues. Peptides targeting to mouse and human CSCs were screened from an M13 phage display library. The first subset of cancer stem cell homing peptides (CSC HPs), CSC HP-1 to -12, were screened with mouse EMT6 breast cancer stem cells. Among them, CSC HP-1, CSC HP-3, CSC HP-8, CSC HP-9, and CSC HP-10 can bind to mouse CT26 colon CSCs; CSC HP-1, CSC HP-2, CSC HP-3, and CSC HP-8 can bind to mouse Hepa1-6 liver CSCs; as well as CSC HP-1, CSC HP-2, CSC HP-3, CSC HP-8, CSC HP-9, CSC HP-10, and CSC HP-11 can bind to human PANC-1 pancreatic CSCs...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29755127/a-novel-long-non-coding-rna-linc-znf469-3-promotes-lung-metastasis-through-mir-574-5p-zeb1-axis-in-triple-negative-breast-cancer
#15
Po-Shun Wang, Cheng-Han Chou, Cheng-Han Lin, Yun-Chin Yao, Hui-Chuan Cheng, Hao-Yi Li, Yu-Chung Chuang, Chia-Ning Yang, Luo-Ping Ger, Yu-Chia Chen, Forn-Chia Lin, Tang-Long Shen, Michael Hsiao, Pei-Jung Lu
Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo...
May 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29752282/niche-mediated-bmp-smad-signaling-regulates-lung-alveolar-stem-cell-proliferation-and-differentiation
#16
Mei-I Chung, Melissa Bujnis, Christina E Barkauskas, Yoshihiko Kobayashi, Brigid L M Hogan
The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we explore its role in the alveolar region, where type 2 epithelial cells (AT2s) and Pdgfrα+ type 2-associated stromal cells (TASCs) are components of the stem cell niche. We use organoids and in vivo alveolar regrowth after pneumonectomy (PNX) - a process that requires proliferation of AT2s and differentiation into type 1 cells (AT1s)...
May 11, 2018: Development
https://www.readbyqxmd.com/read/29752040/mesenchymal-stem-cell-derived-microvesicles-alleviate-pulmonary-arterial-hypertension-by-regulating-renin-angiotensin-system
#17
Zhenjun Liu, Jinghu Liu, Mengyuan Xiao, Junxian Wang, Feng Yao, Weikai Zeng, Liqin Yu, Yuejie Guan, Wenyan Wei, Zijian Peng, Kunpeng Zhu, Jin Wang, Zhongyuan Yang, Jixin Zhong, Jianying Chen
In recent years, microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been proved to be able to improve the outcome of pulmonary arterial hypertension (PAH) in many respects, but the underlying mechanisms of it still remain unclear. Because the renin-angiotensin system (RAS) has been found to be closely related to PAH, the present study was designed to investigate whether the effect of MSC-derived MVs on PAH was correlated with RAS. MVs were isolated and purified from bone marrow MSCs. PAH rat models were established by a single intraperitoneal injection of 1% monocrotaline (MCT, 50 mg/Kg)...
March 15, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29749381/effect-of-bmi1-over-expression-on-gene-expression-in-adult-and-embryonic-murine-neural-stem-cells
#18
Mythily Ganapathi, Nathan C Boles, Carol Charniga, Steven Lotz, Melissa Campbell, Sally Temple, Randall H Morse
The ability of isolated neural stem cells (NSCs) to proliferate as neurospheres is indicative of their competence as stem cells, and depends critically on the polycomb group (PcG) member Bmi1: knockdown of Bmi1 results in defective proliferation and self-renewal of isolated NSCs, whereas overexpression of Bmi1 enhances these properties. Here we report genome-wide changes in gene expression in embryonic and adult NSCs (eNSCs and aNSCs) caused by overexpression of Bmi1. We find that genes whose expression is altered by perturbations in Bmi1 levels in NSCs are mostly distinct from those affected in other multipotent stem/progenitor cells, such as those from liver and lung, aside from a small core of common targets that is enriched for genes associated with cell migration and mobility...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29744913/cartilage-hair-hypoplasia-with-cutaneous-lymphomatoid-granulomatosis
#19
D Sathishkumar, J E Gach, M Ogboli, M Desai, T Cole, W Högler, J Motwani, A Norton, B Morland, I Colmenero
Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Simultaneously, she developed multiple indurated plaques involving her face, which had histological findings of granulomatous inflammation and EBV-associated low-grade lymphomatoid granulomatosis...
May 10, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29744876/flubendazole-elicits-anti-metastatic-effects-in-triple-negative-breast-cancer-via-stat3-inhibition
#20
Eunhye Oh, Yoon-Jae Kim, Hyunsook An, Daeil Sung, Tae-Min Cho, Lee Farrand, Seojin Jang, Jae Hong Seo, Ji Young Kim
Tumor metastasis remains the cause of 90% of cancer-related deaths. Cancer stem cells (CSC) are thought to be responsible for the aggressive and metastatic nature of triple-negative breast cancers (TNBC), and new therapeutic strategies are being devised to target them. Flubendazole (FLU) is a widely used anthelmintic agent that also exhibits anticancer activity in several cancer types. The aim of the present study was to characterize the mechanism of action of FLU on breast cancer stem cell (BCSC)-like properties and metastasis in TNBC...
May 9, 2018: International Journal of Cancer. Journal International du Cancer
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