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https://www.readbyqxmd.com/read/28918284/new-insights-into-human-female-reproductive-tract-development
#1
Stanley J Robboy, Takeshi Kurita, Laurence Baskin, Gerald R Cunha
We present a detailed review of the embryonic and fetal development of the human female reproductive tract utilizing specimens from the 5th through the 22nd gestational week. Hematoxylin and eosin (H&E) as well as immunohistochemical stains were used to study the development of the human uterine tube, endometrium, myometrium, uterine cervix and vagina. Our study revisits and updates the classical reports of Koff (1933) and Bulmer (1957) and presents new data on development of human vaginal epithelium. Koff proposed that the upper 4/5ths of the vagina is derived from Müllerian epithelium and the lower 1/5th derived from urogenital sinus epithelium, while Bulmer proposed that vaginal epithelium derives solely from urogenital sinus epithelium...
August 11, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28917901/polysaccharides-based-injectable-hydrogel-compositing-bio-glass-for-cranial-bone-repair
#2
Xiao Bai, Shaoyu Lü, Haidi Liu, Zhen Cao, Piao Ning, Zengqiang Wang, Chunmei Gao, Boli Ni, Dongyang Ma, Mingzhu Liu
Bone disease is a public health problem around the word, and it is urgent to develop novel tissue engineering scaffolds for the complicated cranial bone regeneration. The present work developed a novel triple crosslinked polysaccharides based injectable hydrogel to composite bio-glass (BG) for cranial bone repair. Dynamic mechanical analysis showed the storage modulus (G') of the hydrogel reached to ∼4000Pa. While after compositing BG, G' exceeded 4500Pa. The degradation behavior of the hydrogel is influenced by hydrogel composition, crosslinking methods and degradation environment...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917287/intraoperative-computed-tomography-in-cranial-neurosurgery
#3
REVIEW
Christian Schichor, Nicole Terpolilli, Jun Thorsteinsdottir, Jörg-Christian Tonn
The challenge for treating complex lesions with the aim of minimal surgery-related morbidity has generated an increasing demand for sophisticated intraoperative imaging modalities. Newest generations of intraoperative computed tomography (CT) scanners offer a multitude of hardware and software improvements resulting in higher image quality that further propagates its everyday usage in the interdisciplinary operative setting. This article describes workflow and applicability of intraoperative CT scanning in cranial neurosurgery, in subspecialties like skull base or vascular neurosurgery, and its advantages and limitations...
October 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28917250/emerging-technologies-in-stereotactic-body-radiotherapy
#4
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28914866/-extended-endoscopic-endonasal-posterior-transclival-approach-to-tumors-of-the-clival-region-and-ventral-posterior-cranial-fossa-part-1-topographic-and-anatomical-features-of-the-clivus-and-adjacent-structures
#5
A N Shkarubo, K V Koval', G F Dobrovol'skiy, M A Shkarubo, V V Karnaukhov, B A Kadashev, D N Andreev, I V Chernov, O A Gadzhieva, O Yu Aleshkina, E A Anisimova, P L Kalinin, M A Kutin, D V Fomichev, O I Sharipov, D B Ismailov, E S Selivanov
OBJECTIVE: to describe the main topographic and anatomical features of the clival region and its adjacent structures for improvement and optimization of the extended endoscopic endonasal posterior (transclival) approach for resection of tumors of the clival region and ventral posterior cranial fossa. MATERIAL AND METHODS: We performed a craniometric study of 125 human skulls and a topographic anatomical study of heads of 25 cadavers, the arterial and venous bed of which was stained with colored silicone (the staining technique was developed by the authors) to visualize bed features and individual variability...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28904458/can-transcranial-color-doppler-spectral-signatures-be-a-novel-biomarker-for-monitoring-cerebrovascular-autoregulation-and-intracranial-pressure-a-speculative-synthesis
#6
Sandhya Mangalore, Kotresh, Rakshith Srinivasa, Alangar Sathyaranjandas Hegde, Rangashetty Srinivasa
BACKGROUND: Trans Cranial Colour Doppler (TCCD) has been extensively used in various neurological and neurosurgical conditions causing severe raise in the intracranial pressure (ICP). MATERIAL AND METHOD: Our study explores the sequential evolution of TCCD flow pattern by correlating with pupillary reactivity, Glasgow coma scale (GCS), and imaging. Our cohort consisted of thirty patients with ten patients in each subgroup admitted to the neuro-Intensive Care Unit (NICU) for various neurological and neurosurgical causes...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28904453/hospital-based-retrospective-study-of-cryptococcal-meningitis-in-a-large-cohort-from-india
#7
Karkal Ravishankar Naik, Aralikatte Onkarappa Saroja, Darshan Kiran Doshi
BACKGROUND: Cryptococcal meningitis is an important and a fatal neuroinfection. Early diagnosis and treatment is of utmost importance in reducing morbidity and mortality. MATERIALS AND METHODS: Data of patients with laboratory-confirmed cryptococcal meningitis seen in tertiary care hospital were reviewed. Details of demographic profile, clinical data, laboratory parameters, complications, and in-hospital mortality were studied. RESULTS: Among 97 patients with cryptococcal meningitis (79 men, 18 women), 88 were HIV-positive, two were diabetic, and seven were sporadic...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28895136/the-evolution-of-hominoid-cranial-diversity-a-quantitative-genetic-approach
#8
Lauren Schroeder, Noreen von Cramon-Taubadel
Hominoid cranial evolution is characterized by substantial phenotypic diversity, yet the cause of this variability has rarely been explored. Quantitative genetic techniques for investigating evolutionary processes underlying morphological divergence are dependent on the availability of good ancestral models, a problem in hominoids where the fossil record is fragmentary and poorly understood. Here, we use a maximum likelihood approach based on a Brownian motion model of evolutionary change to estimate nested hypothetical ancestral forms from 15 extant hominoid taxa...
September 12, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28893644/high-bone-mass-due-to-novel-lrp5-and-amer1-mutations
#9
Alice Costantini, Päivi Kekäläinen, Riikka E Mäkitie, Outi Mäkitie
WNT signaling is a key regulator of bone metabolism and its increased or decreased activity leads to skeletal disorders. Here we describe two patients with high bone mass (HBM) caused by novel mutations in two different WNT pathway components. The first patient is a 53-year-old male with HBM. He was diagnosed at adult age based on significantly increased bone mineral density (BMD). He has undergone several surgeries due to excessive bone in ear canals, bilateral jaw exostoses and mandibular tori. Radiographs show severe cortical thickening of cranial and long bones...
September 8, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28890040/risk-of-deep-vein-thrombosis-in-neurosurgery-state-of-the-art-on-prophylaxis-protocols-and-best-clinical-practices
#10
REVIEW
Mario Ganau, Lara Prisco, Helene Cebula, Julien Todeschi, Houssem Abid, Gianfranco Ligarotti, Raoul Pop, Francois Proust, Salvatore Chibbaro
OBJECTIVE: To analytically discuss some protocols in Deep vein thrombosis (DVT)/pulmonary Embolism (PE) prophylaxis currently use in Neurosurgical Departments around the world. DATA SOURCES: Analysis of the prophylaxis protocols in the English literature: An analytical and narrative review of literature concerning DVT prophylaxis protocols in Neurosurgery have been conducted by a PubMed search (back to 1978). DATA EXTRACTION: 80 abstracts were reviewed, and 74 articles were extracted...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28890030/corpus-callosal-lipoma-extending-as-nasal-encephalocoel-cranial-lipomeningocoel
#11
Abhidha Shah, Survendra Rai, Atul Goel
A hitherto unreported case is presented wherein a 2year old child had a 'cranial lipomeningocoel' or a 'nasal lipo-encephalocoel'. The child presented with a growing mass in the base of the nose. Investigations revealed that the nasal mass was a lipoma that was an extension of intracranial lipoma. The intracranial component extended up to corpus callosum. Resection of the extracranial extension and basal reconstruction resulted in cosmetic recovery.
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28889128/hemorrhage-detection-and-incidence-during-magnetic-resonance-guided-deep-brain-stimulator-implantations
#12
Alastair J Martin, Philip A Starr, Jill L Ostrem, Paul S Larson
BACKGROUND/AIMS: Intraoperative magnetic resonance imaging (iMRI) is increasingly used to implant deep brain stimulator (DBS) electrodes. The approach has the advantages of a high targeting accuracy, minimization of brain penetrations, and allowance of implantation under general anesthesia. The hemorrhagic complications of iMRI-guided DBS implantation have not been studied in a large series. We report on the incidence and characteristics of hemorrhage during these procedures. METHODS: Hemorrhage incidence was assessed in a series of 231 iMRI procedures (374 electrodes implanted)...
September 9, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28888393/hypertrophic-osteoarthropathy-in-a-young-adult-male-from-berber-sudan-2nd-3rd-century-ce
#13
M Binder, M Saad
Hypertrophic osteoarthropathy (HOA) is a pathological condition characterised by extensive periosteal new bone formation (NBF) on the diaphyses of the long bones, metacarpal and metatarsal bones. In modern clinical contexts, the secondary form of the disease is common and most often occurs secondary to intra-thoracic cancer and other forms of chronic pulmonary disease. Paleopathological evidence for HOA on the other hand has only occasionally been reported. Here we report a young adult male from the Meriotic cemetery at Berber in Sudan (2nd-3rd century CE) displaying widespread NBF on the diaphyses of the upper and lower limb bones, metacarpal and metatarsal bones, as well as the pelvis and scapulae...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28887277/single-step-resection-of-an-intraosseous-meningioma-and-cranial-reconstruction-technical-note
#14
C E Broeckx, T J J Maal, R D Vreeken, R R M Bos, M Ter Laan
OBJECTIVE: Simultaneous tumour resection and cranial reconstruction can be a challenging task. Surgical navigation is an indispensible tool in making this single-step procedure possible. In this case report we describe a new technique for this procedure to ensure a precise resection and optimal fit of the implant in a patient with an intraosseous meningioma. METHODS: We generated a 3D model of the patients skull based on a CT-scan and created a digital 'resection line' object using 3D Studio Max 2016 software...
September 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28885697/second-look-arthroscopic-findings-after-cora-based-leveling-osteotomy
#15
Barbara Vasquez, Don Hulse, Brian Beale, Sharon Kerwin, Chad Andrews, Brian W Saunders
OBJECTIVE: To describe the arthroscopic appearance of intra-articular structures mid-term (9 months) and long-term (>12 months) after CORA-based leveling osteotomy (CBLO). STUDY DESIGN: Case series. ANIMALS: Dogs (n = 41) with second-look arthroscopy of the stifle after CBLO for treatment of a cranial cruciate ligament (CCL) deficiency. Both stifles were re-evaluated (stifles n = 42) in 1 dog. METHODS: Medical records of dogs that had second-look arthroscopy after CBLO were reviewed...
September 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28885438/a-volumetric-and-craniometric-analysis-of-cranial-base-differences-in-unicoronal-craniosynostosis
#16
Daniel M Mazzaferro, Ari M Wes, Sanjay Naran, Scott P Bartlett, Jesse A Taylor
BACKGROUND: The authors hypothesized that patients with unicoronal craniosynostosis (UCS) have deviation of the vault, cranial base, and face resulting in significant differences in skull base morphology and segmental cranial vault volume relative to nonaffected controls. METHODS: Unicoronal craniosynostosis patients were collected from the authors' IRB-approved, prospective, craniofacial registry; controls were from a trauma registry. Mimics software was used to compare those with UCS to controls for a series of standardized craniometric angles and distances...
September 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28885117/the-interperiosteodural-concept-applied-to-the-jugular-foramen-and-its-compartmentalization
#17
Florian Bernard, Ilyess Zemmoura, Jean Philippe Cottier, Henri-Dominique Fournier, Louis-Marie Terrier, Stéphane Velut
OBJECTIVE The dura mater is made of 2 layers: the endosteal layer (outer layer), which is firmly attached to the bone, and the meningeal layer (inner layer), which directly covers the brain and spinal cord. These 2 dural layers join together in most parts of the skull base and cranial convexity, and separate into the orbital and perisellar compartments or into the spinal epidural space to form the extradural neural axis compartment (EDNAC). The EDNAC contains fat and/or venous blood. The aim of this dissection study was to anatomically verify the concept of the EDNAC by focusing on the dural layers surrounding the jugular foramen area...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28882584/prophylactic-cranial-irradiation-pci-vs-active-mri-surveillance-for-small-cell-lung-cancer-the-case-for-equipoise
#18
REVIEW
Chad G Rusthoven, Brian D Kavanagh
Prophylactic cranial irradiation (PCI) for small-cell lung cancer (SCLC) offers a consistent reduction in the incidence of brain metastases (BM), at the cost of measurable toxicity to neurocognitive function and quality of life in the setting of characteristic pathologic changes to the brain. The sequelae of PCI have historically been justified by the perception of an overall survival (OS) advantage specific to SCLC. This rationale has now been challenged by a randomized trial in extensive-stage SCLC demonstrating equivalent progression-free survival and a trend toward improved OS with PCI omission in the context of modern MRI staging, surveillance, and salvage therapy...
September 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28882369/3d-printed-tcp-based-scaffold-incorporating-vegf-loaded-plga-microspheres-for-craniofacial-tissue-engineering
#19
F Fahimipour, M Rasoulianboroujeni, E Dashtimoghadam, K Khoshroo, M Tahriri, F Bastami, D Lobner, L Tayebi
OBJECTIVE: Vascularization is a critical process during bone regeneration/repair and the lack of tissue vascularization is recognized as a major challenge in applying bone tissue engineering methods for cranial and maxillofacial surgeries. The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/β-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model. METHODS: The paste, composed of (VEGF-loaded PLGA)-containing gelatin/alginate/β-TCP in water, was loaded into standard Nordson cartridges and promptly employed for printing the scaffolds...
September 4, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28876393/a-new-saurolophine-hadrosaurid-dinosauria-ornithopoda-from-the-upper-cretaceous-of-shandong-china
#20
Jialiang Zhang, Xiaolin Wang, Qiang Wang, Shunxing Jiang, Xin Cheng, Ning Li, Rui Qiu
A new saurolophine hadrosaurid, Laiyangosaurus youngi gen. et sp. nov. is described and phylogenetically analyzed based on several cranial elements from the Jingangkou Formation, Wangshi Group, Upper Cretaceous of Laiyang, Shandong, China. Laiyangosaurus youngi differs from other members of the saurolophine clade on the basis of a number of autapomorphies, including a prominent and narrow ridge on the lateral side of the nasal which forms the posterodorsal and posterior margin of the circumnasal depression, a primary ridge that runs along most of the maxillary tooth row that is slightly deflected posteriorly, a retroarticular process of the surangular that is dorsolateroposteriorlly recurved, and orbital margins that are wider than the infratemporal margins of the jugal...
August 31, 2017: Anais da Academia Brasileira de Ciências
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