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https://www.readbyqxmd.com/read/29453207/hippocampal-ripple-oscillations-and-inhibition-first-network-models-frequency-dynamics-and-response-to-gaba-modulators
#1
José R Donoso, Dietmar Schmitz, Nikolaus Maier, Richard Kempter
Hippocampal ripples are involved in memory consolidation, but the mechanisms underlying their generation remain unclear. Models relying on interneuron networks in the CA1 region disagree on the predominant source of excitation to interneurons: either 'direct', via the Schaffer collaterals that provide feedforward input from CA3 to CA1, or 'indirect', via the local pyramidal cells in CA1, which are embedded in a recurrent excitatory-inhibitory network. Here, we used physiologically constrained computational models of basket-cell networks to investigate how they respond to different conditions of transient, noisy excitation...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29451501/transitions-in-physiological-coupling-between-heartbeat-and-pulse-across-sleep-stages
#2
Qianli D Y Ma, Changjuan Ji, Huanhuan Xie, Kai Yin, Zhen Ma, Chunhua Bian
The aim of this study is to investigate the coupling behavior between heartbeat and pulse of blood flow at different sleep stages, and to explore the feasibility of using this coupling strength for automatic sleep staging.
 Approach: The electrocardiogram (ECG) and photoplethysmography (PPG) signals are recorded during sleep, and R-wave-to-R-wave intervals (RRI) and Pulse-to-Pulse intervals (PPI) are extracted respectively. The detrended cross-correlation analysis (DCCA) is applied to quantify long-range cross correlations between the RRIs and PPIs across sleep stages...
February 16, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29449429/heterogeneous-origins-of-human-sleep-spindles-in-different-cortical-layers
#3
Donald J Hagler, Istvan Ulbert, Lucia Wittner, Lorand Erőss, Joseph R Madsen, Orrin Devinsky, Werner Doyle, Daniel Fabo, Sydney S Cash, Eric Halgren
Sleep spindles are a cardinal feature in human NREM sleep and may be important for memory consolidation. We studied the intracortical organization of spindles in men and women by recording spontaneous sleep spindles from different cortical layers using linear microelectrode arrays. Two patterns of spindle generation were identified using visual inspection, and confirmed with factor analysis. Spindles (10-16Hz) were largest and most common in upper and middle channels, with limited involvement of deep channels...
February 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29438803/sleep-state-dependence-of-optogenetically-evoked-responses-in-neuronal-nitric-oxide-synthase-positive-cells-of-the-cerebral-cortex
#4
Dmitry Gerashchenko, Michelle A Schmidt, Mark R Zielinski, Michele E Moore, Jonathan P Wisor
Slow-wave activity (SWA) in the electroencephalogram during slow-wave sleep (SWS) varies as a function of sleep-wake history. A putative sleep-active population of neuronal nitric oxide synthase (nNOS)-containing interneurons in the cerebral cortex, defined as such by the expression of Fos in animals euthanized after protracted deep sleep, may be a local regulator of SWA. We investigated whether electrophysiological responses to activation of these cells are consistent with their role of a local regulator of SWA...
February 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29422509/identifying-phase-amplitude-coupling-in-cyclic-alternating-pattern-using-masking-signals
#5
Chien-Hung Yeh, Wenbin Shi
Judiciously classifying phase-A subtypes in cyclic alternating pattern (CAP) is critical for investigating sleep dynamics. Phase-amplitude coupling (PAC), one of the representative forms of neural rhythmic interaction, is defined as the amplitude of high-frequency activities modulated by the phase of low-frequency oscillations. To examine PACs under more or less synchronized conditions, we propose a nonlinear approach, named the masking phase-amplitude coupling (MPAC), to quantify physiological interactions between high (α/lowβ) and low (δ) frequency bands...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29419680/mir-664a-3p-expression-in-patients-with-obstructive-sleep-apnea-a-potential-marker-of-atherosclerosis
#6
Kun Li, Zhiting Chen, Yanwen Qin, Yongxiang Wei
The early prediction of atherosclerosis (AS) is important in the management of obstructive sleep apnea patients (OSA). MicroRNA (miRNA) plays a vital role in the evolution of OSA and AS. Its differential expression may therefore serve as a diagnostic and prognostic biomarker of AS in OSA. The aim of this study was to identify specific serum miRNAs that could serve as a novel screening signature of AS in OSA patients. The specificity and sensitivity of these miRNAs in the early diagnosis of AS in OSA patients were then determined...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29414594/changes-in-sleep-patterns-after-vagus-nerve-stimulation-deep-brain-stimulation-or-epilepsy-surgery-systematic-review-of-the-literature
#7
REVIEW
Óscar Romero-Osorio, Sebastián Gil-Tamayo, Daniel Nariño, Diego Rosselli
PURPOSE: Perform a systematic review of the literature on the effects of vagus nerve stimulation (VNS), deep brain stimulation (DBS) and epilepsy surgery in subjective and objective sleep parameters. METHODS: We performed a literature search in the main medical databases: Medline, Embase, Cochrane, DARE and LILACS, looking for studies that evaluated the effects of VNS, DBS or epilepsy surgery on sleep parameters. In all, 36 studies, coming from 11 countries, including reviews, cohort studies, case series and case reports were included...
January 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29384860/bilateral-subthalamic-deep-brain-stimulation-initial-impact-on-nonmotor-and-motor-symptoms-in-parkinson-s-disease-an-open-prospective-single-institution-study
#8
Sandra Kurcova, Jan Bardon, Miroslav Vastik, Marketa Vecerkova, Monika Frolova, Lenka Hvizdosova, Martin Nevrly, Katerina Mensikova, Pavel Otruba, David Krahulik, Egon Kurca, Stefan Sivak, Jana Zapletalova, Petr Kanovsky
Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains.Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up.This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29379037/detection-of-time-frequency-and-direction-resolved-communication-within-brain-networks
#9
Barry Crouch, Linda Sommerlade, Peter Veselcic, Gernot Riedel, Björn Schelter, Bettina Platt
Electroencephalography (EEG) records fast-changing neuronal signalling and communication and thus can offer a deep understanding of cognitive processes. However, traditional data analyses which employ the Fast-Fourier Transform (FFT) have been of limited use as they do not allow time- and frequency-resolved tracking of brain activity and detection of directional connectivity. Here, we applied advanced qEEG tools using autoregressive (AR) modelling, alongside traditional approaches, to murine data sets from common research scenarios: (a) the effect of age on resting EEG; (b) drug actions on non-rapid eye movement (NREM) sleep EEG (pharmaco-EEG); and (c) dynamic EEG profiles during correct vs incorrect spontaneous alternation responses in the Y-maze...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378970/landau-ginzburg-theory-of-cortex-dynamics-scale-free-avalanches-emerge-at-the-edge-of-synchronization
#10
Serena di Santo, Pablo Villegas, Raffaella Burioni, Miguel A Muñoz
Understanding the origin, nature, and functional significance of complex patterns of neural activity, as recorded by diverse electrophysiological and neuroimaging techniques, is a central challenge in neuroscience. Such patterns include collective oscillations emerging out of neural synchronization as well as highly heterogeneous outbursts of activity interspersed by periods of quiescence, called "neuronal avalanches." Much debate has been generated about the possible scale invariance or criticality of such avalanches and its relevance for brain function...
January 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29358069/pupil-size-coupling-to-cortical-states-protects-the-stability-of-deep-sleep-via-parasympathetic-modulation
#11
Özge Yüzgeç, Mario Prsa, Robert Zimmermann, Daniel Huber
During wakefulness, pupil diameter can reflect changes in attention, vigilance, and cortical states. How pupil size relates to cortical activity during sleep, however, remains unknown. Pupillometry during natural sleep is inherently challenging since the eyelids are usually closed. Here, we present a novel head-fixed sleep paradigm in combination with infrared back-illumination pupillometry (iBip) allowing robust tracking of pupil diameter in sleeping mice. We found that pupil size can be used as a reliable indicator of sleep states and that cortical activity becomes tightly coupled to pupil size fluctuations during non-rapid eye movement (NREM) sleep...
January 11, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29332107/the-sleep-architecture-of-saudi-arabian-patients-with-kleine-levin-syndrome
#12
Saad M Al Shareef, Aljohara S Almeneessier, Omeima Hammad, Richard M Smith, Ahmed S BaHammam
To establish baseline sleep architecture during an acute attack of Kleine-Levin syndrome (KLS) in a cohort of Saudi Arabian KLS patients and compare these characteristics with other published cohorts. Methods: This was a retrospective cohort study of the polysomnographic characteristics of 10 typical symptomatic Saudi Arabian KLS patients attending the University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia between 2002 and 2015. Data were captured by nocturnal polysomnography during an acute attack of hypersomnia and compared with other published cohorts identified via a systematic literature search...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29306367/how-deep-to-sleep-for-procedural-echocardiography
#13
EDITORIAL
Alan C Finley, Roman Sniecinski
No abstract text is available yet for this article.
January 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29305874/an-erp-study-of-multidimensional-source-retrieval-in-depression
#14
Elyssa M Barrick, Daniel G Dillon
We collected event-related potentials (ERPs) from 24 unmedicated adults with Major Depressive Disorder (MDD) and 24 controls during source memory retrieval. Words were encoded on the left or right during animacy and mobility judgments. Mobility judgments were slower than animacy judgments, suggesting deeper encoding. Participants then recalled the encoding judgment (Question cue) and position (Side cue) for each word. Depressed adults, but not controls, showed better accuracy for words from the mobility task presented under the Question vs...
January 3, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29304420/local-changes-in-computational-non-rapid-eye-movement-sleep-depth-in-infants
#15
Anna-Liisa Satomaa, Outi Saarenpää-Heikkilä, Eero Huupponen, Turkka Kirjavainen, Juhani Heinonen, Sari-Leena Himanen
OBJECTIVE: Deep NREM sleep and its hallmark EEG phenomenon slow wave activity (SWA) are under homeostatic control in adults. SWA is also locally regulated as it increases in the brain areas that have been used intensively. Moreover, in children, SWA is a marker of cortical maturation. In the present study the local properties of NREM sleep depth were evaluated using the quantitative mean frequency method. We aimed to study if age is related to NREM sleep depth in young infants. In addition, we studied if young infants have local differences in their NREM sleep...
October 16, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29304185/high-body-mass-index-is-a-risk-factor-for-difficult-deep-sedation-in-percutaneous-mitral-valve-repair
#16
Katharina Hellhammer, Shazia Afzal, Renate Tigges, Maximilian Spieker, Tienush Rassaf, Tobias Zeus, Ralf Westenfeld, Malte Kelm, Patrick Horn
BACKGROUND: The safety and efficacy of deep sedation (DS) in MitraClip® procedures have been shown previously. However, clinical experience demonstrates that in some patients DS is difficult to achieve. We hypothesize that some patient characteristics can predict difficult DS. METHODS: We prospectively analysed 69 patients undergoing MitraClip® procedures using DS. Application of DS was graded as simple (group 1) or difficult (group 2) depending on a cumulative score based on one point for each of the following criteria: decrease in oxygen saturation, retention of carbon dioxide, disruptive body movements, and the need for catecholamines...
2018: PloS One
https://www.readbyqxmd.com/read/29303070/is-there-a-role-for-lifestyle-interventions-in-obsessive-compulsive-and-related-disorders
#17
Leonardo F Fontenelle, Julliana N Quintas, Murat Yücel
Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunately, the application of these treatments in milder forms of illness and subclinical samples, which affect a substantial portion of the population, is not justifiable by their costs (e.g. cognitive-behavioral therapy) and/or potential for side effects (serotonin-reuptake inhibitors associated sexual side effects)...
January 4, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29277652/transient-synchronization-of-hippocampo-striato-thalamo-cortical-networks-during-sleep-spindle-oscillations-induces-motor-memory-consolidation
#18
Arnaud Boutin, Basile Pinsard, Arnaud Boré, Julie Carrier, Stuart M Fogel, Julien Doyon
Sleep benefits motor memory consolidation. This mnemonic process is thought to be mediated by thalamo-cortical spindle activity during NREM-stage2 sleep episodes as well as changes in striatal and hippocampal activity. However, direct experimental evidence supporting the contribution of such sleep-dependent physiological mechanisms to motor memory consolidation in humans is lacking. In the present study, we combined EEG and fMRI sleep recordings following practice of a motor sequence learning (MSL) task to determine whether spindle oscillations support sleep-dependent motor memory consolidation by transiently synchronizing and coordinating specialized cortical and subcortical networks...
December 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/29246267/autonomic-nervous-system-functioning-related-to-nocturnal-sleep-in-patients-with-chronic-fatigue-syndrome-compared-to-tired-controls
#19
Maija Orjatsalo, Anniina Alakuijala, Markku Partinen
STUDY OBJECTIVES: Autonomic nervous system (ANS) dysfunction is common in chronic fatigue syndrome (CFS). One of the main complaints in CFS is unrefreshing sleep. We aimed to study the nocturnal cardiac ANS in different sleep stages in patients filling the 2015 Institute of Medicine CFS diagnostic criteria. METHODS: In this case series study, the nocturnal heart rate variability and blood pressure (BP) variables in polysomnography were studied in groups of patients with CFS (n = 8) and tired controls (n = 8) aged 16-49 years...
December 13, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29235907/a-validation-study-of-fitbit-charge-2%C3%A2-compared-with-polysomnography-in-adults
#20
Massimiliano de Zambotti, Aimee Goldstone, Stephanie Claudatos, Ian M Colrain, Fiona C Baker
We evaluated the performance of a consumer multi-sensory wristband (Fitbit Charge 2™), against polysomnography (PSG) in measuring sleep/wake state and sleep stage composition in healthy adults. In-lab PSG and Fitbit Charge 2™ data were obtained from a single overnight recording at the SRI Human Sleep Research Laboratory in 44 adults (19-61 years; 26 women; 25 Caucasian). Participants were screened to be free from mental and medical conditions. Presence of sleep disorders was evaluated with clinical PSG...
December 13, 2017: Chronobiology International
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