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https://www.readbyqxmd.com/read/29911288/a-circadian-rhythm-in-both-complement-cascade-comc-activation-and-sphingosine-1-phosphate-s1p-levels-in-human-peripheral-blood-supports-a-role-for-the-comc-s1p-axis-in-circadian-changes-in-the-number-of-stem-cells-circulating-in-peripheral-blood
#1
Marta Budkowska, Ewa Ostrycharz, Adrianna Wojtowicz, Zuzanna Marcinowska, Jarosław Woźniak, Mariusz Z Ratajczak, Barbara Dołęgowska
The number of hematopoietic stem/progenitor cells (HSPCs) circulating in peripheral blood (PB) is regulated by a circadian rhythm, and more HSPCs circulate in PB in the morning hours than at night. Different mechanisms have been proposed that might regulate this process, including changes in tonus of β-adrenergic innervation of bone marrow (BM) tissue. Our group reported that in mice circadian changes in the number of HSPCs circulating in PB correlates with diurnal activation of the complement cascade (ComC) and that the mice deficient in C5 component of ComC (C5-KO mice) do not show circadian changes in the number of circulating HSPCs in PB...
June 17, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29908300/acute-and-chronic-escitalopram-alter-eeg-gamma-oscillations-differently-relevance-to-therapeutic-effects
#2
Noémi Papp, Szilvia Vas, Emese Bogáthy, Zita Kátai, Diána Kostyalik, György Bagdy
Brain oscillations in the gamma frequency band of the electroencephalogram (EEG) have been implicated in several sensory and cognitive processes, and have also been associated with numerous neuropsychiatric disorders, including depression. The widely prescribed selective serotonin reuptake inhibitors (SSRIs), similarly to other antidepressants, are known to produce markedly different effects on sleep and behavioral measures with acute and chronic administration. Although there are studies examining the acute effect of escitalopram on slower (<30 Hz) oscillations, we hardly could find any data about the effect of the drug on higher-frequency EEG oscillations (>30 Hz) in different sleep-wake stages, particularly comparing the acute and chronic effects of the drug concerning gamma oscillations...
June 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29904334/sleep-disorders-associated-with-alzheimer-s-disease-a-perspective
#3
REVIEW
Anna Brzecka, Jerzy Leszek, Ghulam Md Ashraf, Maria Ejma, Marco F Ávila-Rodriguez, Nagendra S Yarla, Vadim V Tarasov, Vladimir N Chubarev, Anna N Samsonova, George E Barreto, Gjumrakch Aliev
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29903598/trial-protocol-cognitive-functional-therapy-compared-with-combined-manual-therapy-and-motor-control-exercise-for-people-with-non-specific-chronic-low-back-pain-protocol-for-a-randomised-controlled-trial
#4
Fabiana Terra Cunha Belache, Cíntia Pereira de Souza, Jessica Fernandez, Julia Castro, Paula Dos Santos Ferreira, Elizana Rodrigues de Sousa Rosa, Nathalia Cristina Gimenez de Araújo, Felipe José Jandre Reis, Renato Santos de Almeida, Leandro Alberto Calazans Nogueira, Luís Cláudio Lemos Correia, Ney Meziat-Filho
INTRODUCTION: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise...
June 11, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29887129/the-impact-of-subthalamic-deep-brain-stimulation-on-polysomnographic-sleep-pattern-in-patients-with-parkinson-s-disease-preliminary-report
#5
Jarosław Dulski, Michał Schinwelski, Agnieszka Konkel, Karol Grabowski, Witold Libionka, Piotr Wąż, Sitek E J, Jarosław Sławek
AIM OF THE STUDY: We present the preliminary results of the study focused on the impact of subthalamic deep brain stimulation (DBS-STN) on sleep and other non-motor symptoms (NMS). MATERIALS AND METHODS: Ten patients with advanced PD, underwent two-night polysomnography (PSG) mean 1.1 week before surgery and 6.2 months post DBS programming. NMS were assessed with a set of scales before surgery and 6 months and 12 months following DBS programming. RESULTS: Contrary to previous studies, we noted deterioration of sleep pattern in the follow-up PSG...
June 1, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29884069/physical-activity-and-related-psychosocial-outcomes-from-a-pilot-randomized-trial-of-an-interactive-voice-response-system-supported-intervention-in-the-deep-south
#6
Dori Pekmezi, Cole Ainsworth, Taylor Holly, Victoria Williams, Rodney Joseph, Kaiying Wang, Laura Q Rogers, Bess Marcus, Renee Desmond, Wendy Demark-Wahnefried
BACKGROUND: Physical activity exerts cancer-protective effects, yet most Americans are inactive, especially in the South, where cancer incidence rates are generally higher. Telephone-based approaches can help overcome physical activity intervention barriers in this region (literacy, costs, lack of transportation/technology, distance from facilities) and can be automated via interactive voice response (IVR) systems for improved reach and cost-effectiveness. AIMS: To evaluate the Deep South IVR-supported Active Lifestyle (DIAL) intervention...
June 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29878472/sleep-disorders-in-the-elderly-a-growing-challenge
#7
REVIEW
Kamalesh K Gulia, Velayudhan Mohan Kumar
In contrast to newborns, who spend 16-20 h in sleep each day, adults need only about sleep daily. However, many elderly may struggle to obtain those 8 h in one block. In addition to changes in sleep duration, sleep patterns change as age progresses. Like the physical changes that occur during old age, an alteration in sleep pattern is also a part of the normal ageing process. As people age, they tend to have a harder time falling asleep and more trouble staying asleep. Older people spend more time in the lighter stages of sleep than in deep sleep...
May 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29867419/in-home-sleep-recordings-in-military-veterans-with-posttraumatic-stress-disorder-reveal-less-rem-and-deep-sleep-1-hz
#8
Julie A Onton, Scott C Matthews, Dae Y Kang, Todd P Coleman
Veterans with posttraumatic stress disorder (PTSD) often report suboptimal sleep quality, often described as lack of restfulness for unknown reasons. These experiences are sometimes difficult to objectively quantify in sleep lab assessments. Here, we used a streamlined sleep assessment tool to record in-home 2-channel electroencephalogram (EEG) with concurrent collection of electrodermal activity (EDA) and acceleration. Data from a single forehead channel were transformed into a whole-night spectrogram, and sleep stages were classified using a fully automated algorithm...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29859364/do-diurnal-cortisol-levels-mediate-the-association-between-sleep-disturbances-and-cognitive-impairment
#9
José Haba-Rubio, Sami Ouanes, Yannick Franc, Pedro Marques-Vidal, Gerard Waeber, Peter Vollenweider, Armin von Gunten, Martin Preisig, Christine Kuehner, Enrique Castelao, Raphaël Heinzer, Julius Popp
Previous research found an association between sleep disturbances and cognitive deficits on the one hand, and between increased cortisol levels and poor cognitive performance on the other hand. We hypothesized that cortisol may, at least partially, mediate the link between sleep disturbances and cognitive impairment (CI). We analyzed data from 440 nondemented subjects aged ≥65 years (72.4 ± 4.5 years old, 55.7% women) participating at the population-based CoLaus/PsyCoLaus study, who underwent cognitive evaluation, complete polysomnography and cortisol measures during the day...
May 30, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29859261/standing-sentinel-during-human-sleep-continued-evaluation-of-environmental-stimuli-in-the-absence-of-consciousness
#10
Christine Blume, Renata Del Giudice, Malgorzata Wislowska, Dominik P J Heib, Manuel Schabus
While it is a well-established finding that subject's own names (SON) or familiar voices are salient during wakefulness, we here investigated processing of environmental stimuli during sleep including deep N3 and REM sleep. Besides the effects of sleep depth we investigated how sleep-specific EEG patterns (i.e. sleep spindles and slow oscillations [SOs]) relate to stimulus processing. Using 256-channel EEG we studied processing of auditory stimuli by means of event-related oscillatory responses (de-/synchronisation, ERD/ERS) and potentials (ERPs) in N = 17 healthy sleepers...
May 30, 2018: NeuroImage
https://www.readbyqxmd.com/read/29845108/changes-in-parkinson-s-disease-sleep-symptoms-and-daytime-somnolence-after-bilateral-subthalamic-deep-brain-stimulation-in-parkinson-s-disease
#11
Siddharth Kharkar, Jonathan Richard Ellenbogen, Michael Samuel, Alexandra Rizos, Monty Silverdale, K Ray Chaudhuri, Keyoumars Ashkan
INTRODUCTION: Deep brain stimulation (DBS) markedly improves motor function in advanced Parkinson's disease (PD), but its effect on sleep is less clear. PATIENTS AND METHODS: Forty PD patients who had subthalamic DBS (STN-DBS) were identified from an on-going non-motor naturalistic longitudinal study (NILS). All patients were followed up for at least 6 months, 26 patients had a 1 year follow-up. A total PDSS score of 100 or less, a score in any PDSS-item of 6 or less, and a Epworth score of 10 or more were classified as being significant...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29803760/prolonged-partial-obstruction-during-sleep-is-a-nrem-phenomenon
#12
Sari-Leena Himanen, Lauri Martikkala, Saramia Sulkamo, Antti Rutanen, Eero Huupponen, Mirja Tenhunen, Tiia Saunamäki
OBJECTIVE: Prolonged partial obstruction (PPO) is a common finding in sleep studies. Although not verified, it seems to emerge in deep sleep. We study the effect of PPO on sleep architecture or sleep electroencephalography (EEG) frequency. METHODS: Fifteen OSA patients, 15 PPO + OSA patients and 15 healthy subjects underwent a polysomnography. PPO was detected from Emfit mattress signal. Visual sleep parameters and median NREM sleep frequency of the EEG channels were evaluated...
May 24, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29799622/an-evaluation-of-efficacy-and-safety-of-commonly-prescribed-drugs-and-effect-of-these-drugs-on-quality-of-sleep-in-patients-suffering-from-zoster-associated-pain
#13
Mithilesh K Nayak, Jigar D Kapadia, Chetna K Desai, Mira K Desai, Bela J Shah
This observational, prospective, single-center study was conducted to evaluate the efficacy and safety of commonly prescribed drugs for zoster-associated pain and their impact on quality of sleep at a tertiary care hospital in western India. Patients ≥18 years of age, newly diagnosed with zoster-associated pain were evaluated on days 0, 7, 14, 30, 60, 90, 120, 150, and 180 or until resolution of pain, whichever was earlier, using the Wong Baker FACES Pain Rating Scale, Neuropathic Pain Scale, and Insomnia Severity Index for intensity of pain, quality of pain, and quality of sleep, respectively...
May 25, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29799524/author-correction-deep-sleep-maintains-learning-efficiency-of-the-human-brain
#14
Sara Fattinger, Toon T de Beukelaar, Kathy L Ruddy, Carina Volk, Natalie C Heyse, Joshua A Herbst, Richard H R Hahnloser, Nicole Wenderoth, Reto Huber
This corrects the article DOI: 10.1038/ncomms15405.
May 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29798363/-an-association-between-obstructive-sleep-apnea-hypopnea-syndrome-and-deep-vein-thrombosis-and-pulmonary-embolism
#15
REVIEW
L Li, G H Jin, J Q Lang, N Cui
OSAHS is a kind of the sleep-related breathing disorder, with lack of oxygen. OSAHS can induce many kinds of cardiovascular system diseases. Deep vein thrombosis and pulmonary embolism (deep vein thrombosis and/or pulmonary embolism, DVT and PE) is caused by deep vein thrombosis embolism pulmonary artery trunk or branch pulmonary disorder, potentially lethal diseases of the cardiovascular system. In recent years, researchers have found that OSAHS may have something to do with DVT-PE. So in this review, the relationship was summarized between OSAHS and DVT-PE in epidemiology, pathophysiology, assessment and treatment measures...
August 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29794342/multiclass-classification-of-obstructive-sleep-apnea-hypopnea-based-on-a-convolutional-neural-network-from-a-single-lead-electrocardiogram
#16
Erdenebayar Urtnasan, Jong-Uk Park, Kyoung-Joung Lee
OBJECTIVE: In this paper, we propose a convolutional neural network (CNN)-based deep learning architecture for multiclass classification of obstructive sleep apnea and hypopnea (OSAH) using single-lead electrocardiogram (ECG) recordings. OSAH is the most common sleep-related breathing disorder. Many subjects who suffer from OSAH remain undiagnosed; thus, early detection of OSAH is important. APPROACH: In this study, automatic classification of three classes-normal, hypopnea, and apnea-based on a CNN is performed...
May 24, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29789087/individual-differences-in-adaptability-to-isolated-confined-and-extreme-environments
#17
Paul T Bartone, Gerald P Krueger, Jocelyn V Bartone
INTRODUCTION: Future deep space missions will expose astronauts to more intense stressors than previously encountered. Isolation will be greater and more prolonged, living and work areas more confined, and communications and resupply channels to Earth longer and less reliable. Astronauts will need to function more autonomously, with less guidance and support from Earth. Thus, it is important to select and train astronauts who can adapt and function effectively under extreme and variable conditions...
June 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29782141/in-situ-assembly-of-well-dispersed-ag-nanoparticles-throughout-electrospun-alginate-nanofibers-for-monitoring-human-breath-smart-fabrics
#18
Jun Zhang, Xiao-Xiong Wang, Bin Zhang, Seeram Ramakrishna, Miao Yu, Jian-Wei Ma, Yun-Ze Long
Alginate nanofibers assembled with sliver nanoparticles throughout the whole nanofiber were fabricated by three steps including electrospinning of Na-alginate nanofibers, ion exchange between the sodium and silver ions, and in situ reduction of silver nanoparticles. The content, distribution and size of the nanoparticles are controllable by tuning reaction conditions. Ag/alginate nanofibers exhibit good humidity sensitivity in a wide humidity range from ambient RH (20%) to 85% RH. Interestingly, these humidity sensors can be attached to a 3M-9001V mask for monitoring human breath during exercise and emotion changes, and this smart exhibits accurate and continuous human-breath tracking no matter how fast or slow as well as how deep or shallow...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29775401/electroencephalographic-signals-during-anesthesia-recorded-from-surface-and-depth-electrodes
#19
Ville Jäntti, Tuomo Ylinen, Narayan Puthanmadam Subramaniyam, Kotoe Kamata, Arvi Yli-Hankala, Pasi Kauppinen, Eila Sonkajärvi
Purpose - Anesthesiologists have increasingly started to use EEG based indexes to estimate the level and type of unconsciousness. However, the physiology and biophysics are poorly understood in anesthesiological literature. Methods - EEG was recorded from electrodes on the surface of head, including scalp, as well as DBS (deep brain stimulation) electrodes implanted deep in the brain. Mathematical modeling with a realistic head model was performed to create illustrative images of the sensitivity of electrode montages...
May 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29762755/obstructive-sleep-apnea-during-rem-sleep-is-associated-with-early-signs-of-atherosclerosis-in-women
#20
Mirjam Ljunggren, Eva Lindberg, Karl A Franklin, Patrik Öhagen, Marita Larsson, Jenny Theorell-Haglöw, Tord Naessén
Study Objectives: While obstructive sleep apnea (OSA) is associated with overall cardiovascular disease and mortality, the association with atherosclerotic cardiovascular disease is less clear, especially in women. Recently, it has been suggested that OSA during REM sleep, associated with long apneas and deep desaturations, could have severe cardio-metabolic consequences. The aim of this study was to investigate whether OSA during REM sleep is associated with early signs of atherosclerosis in a population-based sample of women...
May 14, 2018: Sleep
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