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https://www.readbyqxmd.com/read/29221784/assessment-of-intervention-related-changes-in-non-rapid-eye-movement-sleep-depth-importance-of-sleep-depth%C3%A2-changes-within-stage-2
#1
Sultan Qanash, Eleni Giannouli, Magdy Younes
OBJECTIVES: Depth of sleep within non-rapid-eye-movement (non-REM) stage-2 (N2-depth) varies from being nearly similar to stage-1 to nearly similar to stage-3. Differences in N2-depth are not captured by conventional indices of sleep depth (N1-N3 times, arousal/awakening index) when comparing sleep depth under different conditions. Magnitude of changes in N2-depth in the same individual under different experimental conditions, and the importance of measuring these changes are unknown...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29208538/sleep-related-painful-erections-a-meta-analysis-on-the-pathophysiology-and-risks-and-benefits-of-medical-treatments
#2
REVIEW
Sanne Vreugdenhil, Alida Cornelia Weidenaar, Igle Jan de Jong, Mels Frank van Driel
BACKGROUND: Patients with sleep-related painful erections (SRPEs) have frequent awakenings from deep penile pain during nocturnal erections. This results in severe sleep deprivation. AIM: To review the current literature on SRPEs and discuss the pathophysiologic theories and risks and benefits of medical treatments. METHODS: PubMed was searched using the terms sleep-related painful erections, nocturnal priapism, treatment, and sleep-related erections...
December 2, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29198306/sleep-architecture-in-children-with-common-phenotype-of-obstructive-sleep-apnea
#3
Peter Durdik, Anna Sujanska, Stanislava Suroviakova, Melania Evangelisti, Peter Banovcin, Maria Pia Villa
STUDY OBJECTIVES: In children, the effect of the common phenotype of obstructive sleep apnea (OSA) on sleep architecture is not adequately documented. The aim of this study was to evaluate sleep architecture in a pediatric population with the common phenotype of OSA. METHODS: The prospective cross-sectional study included 116 children in the age range of 3 to 8 years with suspected OSA and 51 healthy children. All children underwent standard overnight in-laboratory video polysomnography...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29190336/slow-waves-in-cortical-slices-how-spontaneous-activity-is-shaped-by-laminar-structure
#4
Cristiano Capone, Beatriz Rebollo, Alberto Muñoz, Xavi Illa, Paolo Del Giudice, Maria V Sanchez-Vives, Maurizio Mattia
Cortical slow oscillations (SO) of neural activity spontaneously emerge and propagate during deep sleep and anesthesia and are also expressed in isolated brain slices and cortical slabs. We lack full understanding of how SO integrate the different structural levels underlying local excitability of cell assemblies and their mutual interaction. Here, we focus on ongoing slow waves (SWs) in cortical slices reconstructed from a 16-electrode array designed to probe the neuronal activity at multiple spatial scales...
November 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29160176/impact-of-bedding-volume-on-physiological-and-behavioural-parameters-in-laboratory-mice
#5
Jennifer Freymann, Ping-Ping Tsai, Helge D Stelzer, Reinhard Mischke, Hansjoachim Hackbarth
The standard housing temperature in animal facilities is substantially below the lower critical temperature of mice. This does not only endanger animal welfare, it can also jeopardize scientific research as cold stress has a major impact on mouse physiology. There is some evidence that deep bedding, comparable to nesting material, can help mice to reduce heat loss. Whenever changes are applied to the cage environment, the potential impact on experimental results, including variation, needs to be assessed. An increased variation can result in a conflict between reduction and refinement, when more animals are needed for significance due to the housing design...
December 2017: Laboratory Animals
https://www.readbyqxmd.com/read/29122706/mid-to-long-term-outcomes-of-laparoscopic-sleeve-gastrectomy-in-indian-population-3-7-year-results-a-retrospective-cohort-study
#6
Harshit Garg, Sandeep Aggarwal, Mahesh Chandra Misra, Pratyusha Priyadarshini, Ashish Swami, Lokesh Kashyap, Richa Jaiswal
INTRODUCTION: Few studies have addressed the mid to long term impact of Laparoscopic Sleeve Gastrectomy (LSG) on weight loss and obesity associated co-morbidities, particularly in Indian population. The aim of this study is to assess the efficacy of LSG in morbid obesity over 3-7 years follow up. MATERIALS AND METHODS: Data of all patients who underwent LSG between January 2008 and March 2015 and completed their at least 1 year follow up till March 2016 was retrospectively reviewed using a prospectively collected database...
November 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29121293/brain-functional-connectivity-differentiates-dexmedetomidine-from-propofol-and-natural-sleep
#7
P Guldenmund, A Vanhaudenhuyse, R D Sanders, J Sleigh, M A Bruno, A Demertzi, M A Bahri, O Jaquet, J Sanfilippo, K Baquero, M Boly, J F Brichant, S Laureys, V Bonhomme
Background: We used functional connectivity measures from brain resting state functional magnetic resonance imaging to identify human neural correlates of sedation with dexmedetomidine or propofol and their similarities with natural sleep. Methods: Connectivity within the resting state networks that are proposed to sustain consciousness generation was compared between deep non-rapid-eye-movement (N3) sleep, dexmedetomidine sedation, and propofol sedation in volunteers who became unresponsive to verbal command...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29108303/anesthetic-dreaming-anesthesia-awareness-and-patient-satisfaction-after-deep-sedation-with-propofol-target-controlled-infusion-a-prospective-cohort-study-of-patients-undergoing-day-case-breast-surgery
#8
Marco Cascella, Roberta Fusco, Domenico Caliendo, Vincenza Granata, Domenico Carbone, Maria Rosaria Muzio, Giuseppe Laurelli, Stefano Greggi, Francesca Falcone, Cira Antonietta Forte, Arturo Cuomo
Background: Anesthetic dreaming and anesthesia awareness are well distinct phenomena. Although the incidence of intraoperative awareness is more common among patients who reported a dream after surgery, the exact correlation between the two phenomena remains an unsolved rebus. The main purpose of this study was to investigate anesthetic dreaming, anesthesia awareness and psychological consequences eventually occurred under deep sedation. Intraoperative dreaming experiences were correlated with dream features in natural sleep...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099314/outcomes-in-super-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy
#9
Vitish Singla, Sandeep Aggarwal, Harshit Garg, Lokesh Kashyap, Dilip R Shende, Samagra Agarwal
BACKGROUND: Super obese patients remain a challenge for management because of large liver size resulting in decreased work space and associated comorbidities. OBJECTIVES: To study outcomes in super obese patients undergoing Laparoscopic sleeve gastrectomy (LSG). METHODS: Retrospective data of 123 patients undergoing LSG from January 2008 to March 2015 were analyzed prospectively. RESULTS: Mean age and body mass index (BMI) of 123 patients (± 2 standard deviation [SD]) were 39...
November 3, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29077804/neuropsychological-and-neuropsychiatric-features-of-idiopathic-and-dyt1-dystonia-and-the-impact-of-medical-and-surgical-treatment
#10
Marjan Jahanshahi
Dystonia is a hyperkinetic movement disorder, characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. Executive dysfunction is a feature of cognitive function in idiopathic and DYT1 dystonia. Psychiatric morbidity is increased in dystonia, and depression, anxiety, obsessive compulsive disorders are the most common disorders. Sleep problems and pain are also frequently experienced. Evidence suggest that mood and anxiety disorders are intrinsic to the neurobiology of dystonia, but also that psychiatric co-morbidity can be secondary to pain experience and the psychosocial functioning and quality of life of the patients...
November 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29073146/unified-thalamic-model-generates-multiple-distinct-oscillations-with-state-dependent-entrainment-by-stimulation
#11
Guoshi Li, Craig S Henriquez, Flavio Fröhlich
The thalamus plays a critical role in the genesis of thalamocortical oscillations, yet the underlying mechanisms remain elusive. To understand whether the isolated thalamus can generate multiple distinct oscillations, we developed a biophysical thalamic model to test the hypothesis that generation of and transition between distinct thalamic oscillations can be explained as a function of neuromodulation by acetylcholine (ACh) and norepinephrine (NE) and afferent synaptic excitation. Indeed, the model exhibited four distinct thalamic rhythms (delta, sleep spindle, alpha and gamma oscillations) that span the physiological states corresponding to different arousal levels from deep sleep to focused attention...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29066083/sleep-related-painful-erections-a-case-series-of-24-patients-regarding-diagnostics-and-treatment-options
#12
Sanne Vreugdenhil, Alida Cornelia Weidenaar, Igle Jan de Jong, Mels Frank van Driel
BACKGROUND: Patients with sleep-related painful erections (SRPEs) have deep penile pain during nocturnal erection that wakes them up and disturbs their nights of sleep. This rare parasomnia is poorly recognized by general practitioners and by urologists and sexologists. AIM: To gain more insight into diagnostics and therapeutic options. METHODS: Data from a series of 24 consecutive patients who presented with SRPEs at the outpatient clinic from 1996 to 2015 were retrospectively analyzed...
December 2017: Sexual Medicine
https://www.readbyqxmd.com/read/29063076/restless-legs-syndrome-secondary-to-pontine-infarction-clinical-analysis-of-five-cases
#13
Hou-Zhen Tuo, Ze-Long Tian, Yi-Nong Cui, Xiao-Yang Ma, Chun-Ling Xu, Hong-Yan Bi, Li-Yan Zhang, Yong-Bo Zhang, Wei-Dong Le, William Ondo
OBJECTIVE: Pontine infarction is a common type of stroke in the cerebral deep structures, resulting from occlusion of small penetrating arteries, may manifest as hemi-paralysis, hemi-sensory deficit, ataxia, vertigo, and bulbar dysfunction, but patients presenting with restless legs syndrome (RLS) are extremely rare. Herein, we reported five cases with RLS as a major manifestation of pontine infarction. METHODS: Five cases of pontine infarction related RLS were collected from July 2013 to February 2016...
September 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29061551/an-international-study-on-the-determinants-of-poor-sleep-amongst-15-000-users-of-connected-devices
#14
Guy Fagherazzi, Douae El Fatouhi, Alice Bellicha, Amin El Gareh, Aurélie Affret, Courtney Dow, Lidia Delrieu, Matthieu Vegreville, Alexis Normand, Jean-Michel Oppert, Gianluca Severi
BACKGROUND: Sleep is a modifiable lifestyle factor that can be a target for efficient intervention studies to improve the quality of life and decrease the risk or burden of some chronic conditions. Knowing the profiles of individuals with poor sleep patterns is therefore a prerequisite. Wearable devices have recently opened new areas in medical research as potential efficient tools to measure lifestyle factors such as sleep quantity and quality. OBJECTIVES: The goal of our research is to identify the determinants of poor sleep based on data from a large population of users of connected devices...
October 23, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29060552/optimized-automatic-sleep-stage-classification-using-the-normalized-mutual-information-feature-selection-nmifs-method
#15
Dongrae Cho, Boreom Lee
Sleep is a very important physiological phenomenon for recovery of physical and mental fatigue. Recently, there has been a lot of interest in the quality of sleep and the research is actively under way. In particular, it is important to have a repetitive and regular sleep cycle for good sleep. However, it takes a lot of time to determine sleep stages using physiological signals by experts. In this study, we constructed an optimized classifier based on normalized mutual information feature selection (NMIFS) and kernel based extreme learning machine (K-ELM), and total 4 sleep stages (Awake, weak sleep (stage1+stage2), deep sleep(stage3+stage4) and rapid eye movement (REM)) were automatically classified...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054675/evidence-of-fatigue-disordered-sleep-and-peripheral-inflammation-but-not-increased-brain-tspo-expression-in-seasonal-allergy-a-11-c-pbr28-pet-study
#16
Sandra Tamm, Simon Cervenka, Anton Forsberg, Johanna Estelius, Johan Grunewald, Pär Gyllfors, Bianka Karshikoff, Eva Kosek, Jon Lampa, Catarina Lensmar, Victoria Strand, Torbjörn Åkerstedt, Christer Halldin, Martin Ingvar, Caroline Olgart Höglund, Mats Lekander
Allergy is associated with non-specific symptoms such as fatigue, sleep problems and impaired cognition. One explanation could be that the allergic inflammatory state includes activation of immune cells in the brain, but this hypothesis has not been tested in humans. The aim of the present study was therefore to investigate seasonal changes in the glial cell marker translocator protein (TSPO), and to relate this to peripheral inflammation, fatigue and sleep, in allergy. We examined 18 patients with severe seasonal allergy, and 13 healthy subjects in and out-of pollen season using positron emission tomography (n = 15/13) and the TSPO radioligand [(11)C]PBR28...
October 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29049073/postoperative-outcomes-in-obstructive-sleep-apnea-patients-undergoing-cardiac-surgery-a-systematic-review-and-meta-analysis-of-comparative-studies
#17
Mahesh Nagappa, George Ho, Jayadeep Patra, Jean Wong, Mandeep Singh, Roop Kaw, Davy Cheng, Frances Chung
BACKGROUND: Obstructive sleep apnea (OSA) is a common comorbidity in patients undergoing cardiac surgery and may predispose patients to postoperative complications. The purpose of this meta-analysis is to determine the evidence of postoperative complications associated with OSA patients undergoing cardiac surgery. METHODS: A literature search of Cochrane Database of Systematic Reviews, Medline, Medline In-process, Web of Science, Scopus, EMBASE, Cochrane Central Register of Controlled Trials, and CINAHL until October 2016 was performed...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29046178/a-psychiatric-formulary-for-long-duration-spaceflight
#18
Eric Friedman, Brian Bui
Behavioral health is essential for the safety, well-being, and performance of crewmembers in both human spaceflight and Antarctic exploration. Over the past five decades, psychiatric issues have been documented in orbital spaceflight. In Antarctica, literature suggests up to 5% of wintering crewmembers could meet criteria for a psychiatric illness, including mood disorders, stressor-related disorders, sleep-wake disorders, and substance-related disorders. Experience from these settings indicates that psychiatric disorders on deep space missions must be anticipated...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29037144/trypanosoma-cruzi-specific-mrna-amplification-by-in-vitro-transcription-improves-parasite-transcriptomics-in-host-parasite-rna-mixtures
#19
Rafael Luis Kessler, Daniela Parada Pavoni, Marco Aurelio Krieger, Christian Macagnan Probst
BACKGROUND: Trypanosomatids are a group of protozoan parasites that includes the etiologic agents of important human illnesses as Chagas disease, sleeping sickness and leishmaniasis. These parasites have a significant distinction from other eukaryotes concerning mRNA structure, since all mature mRNAs have an identical species-specific sequence of 39 nucleotides at the 5' extremity, named spliced leader (SL). Considering this peculiar aspect of trypanosomatid mRNA, the aim of the present work was to develop a Trypanosoma cruzi specific in vitro transcription (IVT) linear mRNA amplification method in order to improve parasite transcriptomics analyses...
October 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29018561/disturbed-eeg-sleep-paranoid-cognition-and-somatic-symptoms-identify-veterans-with-post-traumatic-stress-disorder
#20
Harvey Moldofsky, Lorne Rothman, Robert Kleinman, Shawn G Rhind, J Donald Richardson
BACKGROUND: Chronic post-traumatic stress disorder (PTSD) behavioural symptoms and medically unexplainable somatic symptoms are reported to occur following the stressful experience of military combatants in war zones. AIMS: To determine the contribution of disordered EEG sleep physiology in those military combatants who have unexplainable physical symptoms and PTSD behavioural difficulties following war-zone exposure. METHOD: This case-controlled study compared 59 veterans with chronic sleep disturbance with 39 veterans with DSM-IV and clinician-administered PTSD Scale diagnosed PTSD who were unresponsive to pharmacological and psychological treatments...
November 2016: BJPsych Open
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