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https://www.readbyqxmd.com/read/28098351/the-elicitation-of-steady-state-visual-evoked-potentials-during-sleep
#1
James J S Norton, Stephen Umunna, Timothy Bretl
This study confirmed the hypothesis that it is possible to elicit SSVEPs through closed eyelids during NREM sleep. To test this hypothesis, SSVEP amplitudes were measured in eight subjects across two conditions of stimulation (stimulation on and stimulation off) and three brain states (waking, light sleep, and deep sleep). Results showed a significant interaction between stimulation and brain state. In particular, EEG activity at the frequency of stimulation was higher during both light sleep and deep sleep in the stimulation on condition than in the stimulation off condition...
January 18, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28096225/not-so-patchy-story-of-attempted-suicide%C3%A2-leading-to-24%C3%A2-hours-of-deep-sleep-and-survival
#2
Adam Joseph Trist, Hardeep Sahota, Lucy Williams
Here, we present a somewhat unusual suicide attempt where, despite an unbelievable overdose with transdermal fentanyl patches, the patient survived. The patient-a woman aged 70 years, who has suffered from chronic back pain despite starting transdermal fentanyl patches in 2007. The unconventional method of attempted suicide was based on online research into deaths from fentanyl patch toxicity. She had gradually accumulated 100 µg fentanyl patches from repeat prescriptions, applying 14 patches with fatal intent, alongside 2 45 mg mirtazapine tablets, and concurrent therapeutic doses of tramadol and morphine sulfate oral solution...
January 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28095968/catathrenia-nocturnal-groaning-a-social-media-survey-and-state-of-the-art-review
#3
Jose Alonso, Macario Camacho, Dinesh K Chhetri, Christian Guilleminault, Soroush Zaghi
STUDY OBJECTIVES: Catathrenia is an underrecognized nocturnal vocalization phenomenon that can be a source of perplexity to patients, bed partners, and medical providers. Catathrenia is distinct from both sleep talking (a parasomnia with loud talking during sleep) and snoring (noise due to vibration of upper airway soft tissues related to variations in airway resistance). The objective of this review is to provide an evidence-based resource to help the practitioner reliably evaluate and manage patients with this condition...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28093029/low-doses-of-mirtazapine-or-quetiapine-for-transient-insomnia-a-randomised-double-blind-cross-over-placebo-controlled-trial
#4
Julie Karsten, Loes A Hagenauw, Jeanine Kamphuis, Marike Lancel
Low doses of the antidepressant mirtazapine or the neuroleptic quetiapine are often prescribed off-label for insomnia. However, studies on the effects on sleep and hangover effects the following day are scarce. In this randomised, double-blind, cross-over, placebo-controlled trial, the influence of 7.5 mg mirtazapine and 50 mg quetiapine on both normal sleep and sleep disturbed by acoustic stress (traffic noise) as a model for transient insomnia was assessed. Additionally, hangover effects on next-day alertness and cognitive functioning were examined...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28092583/deep-learning-and-insomnia-assisting-clinicians-with-their-diagnosis
#5
Mostafa Shahin, Beena Ahmed, Sana Tmar-Ben Hamida, Fathima Mulaffer, Martin Glos, Thomas Penzel
Effective sleep analysis is hampered by the lack of automated tools catering for disordered sleep patterns and cumbersome monitoring hardware. In this paper, we apply deep learning on a set of 57 EEG features extracted from a maximum of two EEG channels to accurately differentiate between patients with insomnia or controls with no sleep complaints. We investigated two different approaches to achieve this. The first approach used EEG data from the whole sleep recording irrespective of the sleep stage (stage-independent classification), while the second used only EEG data from insomnia-impacted specific sleep stages (stage-dependent classification)...
January 9, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28079877/genome-wide-transposon-screening-and-quantitative-insertion-site-sequencing-for-cancer-gene-discovery-in-mice
#6
Mathias J Friedrich, Lena Rad, Iraad F Bronner, Alexander Strong, Wei Wang, Julia Weber, Matthew Mayho, Hannes Ponstingl, Thomas Engleitner, Carolyn Grove, Anja Pfaus, Dieter Saur, Juan Cadiñanos, Michael A Quail, George S Vassiliou, Pentao Liu, Allan Bradley, Roland Rad
Transposon-mediated forward genetics screening in mice has emerged as a powerful tool for cancer gene discovery. It pinpoints cancer drivers that are difficult to find with other approaches, thus complementing the sequencing-based census of human cancer genes. We describe here a large series of mouse lines for insertional mutagenesis that are compatible with two transposon systems, PiggyBac and Sleeping Beauty, and give guidance on the use of different engineered transposon variants for constitutive or tissue-specific cancer gene discovery screening...
February 2017: Nature Protocols
https://www.readbyqxmd.com/read/28065487/the-effect-of-unilateral-subthalamic-nucleus-deep-brain-stimulation-on-depression-in-parkinson-s-disease
#7
Elizabeth L Birchall, Harrison C Walker, Gary Cutter, Stephanie Guthrie, Allen Joop, Raima A Memon, Ray L Watts, David G Standaert, Amy W Amara
BACKGROUND: Depression is common in Parkinson's disease (PD) and adversely affects quality of life. Both unilateral and bilateral subthalamic (STN) deep brain stimulation (DBS) effectively treat the motor symptoms of PD, but questions remain regarding the impact of unilateral STN DBS on non-motor symptoms, such as depression. METHODS: We report changes in depression, as measured by the Hamilton Depression Rating Scale (HAMD-17), in 50 consecutive PD patients who underwent unilateral STN DBS...
December 27, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/28053819/thalamic-atrophy-contributes-to-low-slow-wave-sleep-in-neuromyelitis-optica-spectrum-disorder
#8
Lei Su, Yujuan Han, Rong Xue, Kristofer Wood, Fu-Dong Shi, Yaou Liu, Ying Fu
Slow wave sleep abnormality has been reported in neuromyelitis optica spectrum disorder (NMOSD), but mechanism for such abnormality is unknown. To determine the structural defects in the brain that account for the decrease of slow wave sleep in NMOSD patients. Thirty-three NMOSD patients and 18 matched healthy controls (HC) were enrolled. Polysomnography was used to monitor slow wave sleep and three-dimensional T1-weighted MRIs were obtained to assess the alterations of grey matter volume. The percentage of deep slow wave sleep decreased in 93% NMOSD patients...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28045886/the-effects-of-kangaroo-care-on-the-sleep-and-wake-states-of-preterm-infants
#9
Farideh Bastani, Nahid Rajai, Zahra Farsi, Heidelise Als
BACKGROUND: Developing interventions that improve deep sleep and quit awake is important to improve the quality of care that is provided to preterm infants. PURPOSE: The aim of this study was to compare the effects of kangaroo care and in-arms-holding on the sleep and wake states of preterm infants. METHODS: A randomized controlled trial design was employed in 2011-2012. Seventy-two stable preterm infants with gestational ages of 32-37 weeks and their mothers were recruited from the neonatal intensive care unit of Valiasr Hospital in Tehran, Iran...
December 29, 2016: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28045036/speed-hysteresis-and-noise-shaping-of-traveling-fronts-in-neural-fields-role-of-local-circuitry-and-nonlocal-connectivity
#10
Cristiano Capone, Maurizio Mattia
Neural field models are powerful tools to investigate the richness of spatiotemporal activity patterns like waves and bumps, emerging from the cerebral cortex. Understanding how spontaneous and evoked activity is related to the structure of underlying networks is of central interest to unfold how information is processed by these systems. Here we focus on the interplay between local properties like input-output gain function and recurrent synaptic self-excitation of cortical modules, and nonlocal intermodular synaptic couplings yielding to define a multiscale neural field...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28040430/association-of-obstructive-sleep-apnea-with-episodic-memory-and-cerebral-microvascular-pathology-a-preliminary-study
#11
Nancy A Kerner, Steven P Roose, Gregory H Pelton, Adam Ciarleglio, Jennifer Scodes, Cody Lentz, Joel R Sneed, D P Devanand
OBJECTIVES: To evaluate the impact of obstructive sleep apnea (OSA) on neurocognitive function and brain morphology in older adults with depression and cognitive impairment. METHODS: We prospectively screened OSA with the STOP-Bang questionnaire in the last 25 patients enrolled into the Donepezil Treatment of Cognitive Impairment and Depression (DOTCODE) trial. High and low probability of OSA were defined as a STOP-Bang score of ≥5 (h-OSA) and of <5 (l-OSA), respectively...
November 17, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28039311/sleep-characteristics-and-cognitive-impairment-in-the-general-population-the-hypnolaus-study
#12
José Haba-Rubio, Helena Marti-Soler, Nadia Tobback, Daniela Andries, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, Armin von Gunten, Martin Preisig, Enrique Castelao, Mehdi Tafti, Raphaël Heinzer, Julius Popp
OBJECTIVE: To assess the association between sleep structure and cognitive impairment in the general population. METHODS: Data stemmed from 580 participants aged >65 years of the population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using validated questionnaires), and a complete polysomnography at home...
December 30, 2016: Neurology
https://www.readbyqxmd.com/read/28026732/-spontaneous-tendon-ruptures-in-the-rheumatoid-hand
#13
J Pech, D Veigl, M Vlček
A spontaneous tendon rupture is a direct consequence of rheumatoid inflammation and can appear without any noticeable impact, often during sleep. The patient then presents with inability to flex or extend metacarpophalageal or interphalangeal joints. Multiple ruptures resulting in impaired function of several fingers can also occur and markedly limit the hand's grip strength. A tear may arise from either mechanical injury to the tendon along its course over bone or connective tissues, or by biochemical action of lysosomal enzymes, released during the inflammation process, on the connective tissue of the tendon...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28011172/wake-sleep-and-cardiovascular-regulatory-changes-in-rats-made-obese-by-a-high-fat-diet
#14
Marco Luppi, Abed A Al-Jahmany, Flavia Del Vecchio, Matteo Cerri, Alessia Di Cristoforo, Timna Hitrec, Davide Martelli, Emanuele Perez, Giovanni Zamboni, Roberto Amici
Obesity is known to be associated with alterations in wake-sleep (WS) architecture and cardiovascular parameters. This study was aimed at assessing the possible influence of diet-induced obesity (DIO) on sleep homeostasis and on the WS state-dependent levels of arterial pressure (AP) and heart rate in the rat. Two groups of age-matched Sprague-Dawley rats were fed either a high-fat hypercaloric diet, leading to DIO, or a normocaloric standard diet (lean controls) for 8 weeks. While under general anesthesia, animals were implanted with instrumentation for the recording of electroencephalogram, electromyogram, arterial pressure, and deep brain temperature...
December 21, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28003693/all-india-difficult-airway-association-2016-guidelines-for-the-management-of-anticipated-difficult-extubation
#15
Pankaj Kundra, Rakesh Garg, Apeksh Patwa, Syed Moied Ahmed, Venkateswaran Ramkumar, Amit Shah, Jigeeshu Vasishtha Divatia, Sumalatha Radhakrishna Shetty, Ubaradka S Raveendra, Jeson R Doctor, Dilip K Pawar, Ramesh Singaravelu, Sabyasachi Das, Sheila Nainan Myatra
Extubation has an important role in optimal patient recovery in the perioperative period. The All India Difficult Airway Association (AIDAA) reiterates that extubation is as important as intubation and requires proper planning. AIDAA has formulated an algorithm based on the current evidence, member survey and expert opinion to incorporate all patients of difficult extubation for a successful extubation. The algorithm is not designed for a routine extubation in a normal airway without any associated comorbidity...
December 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27973741/clicking-the-brain-into-deep-sleep-commentary-on-weigenand-et%C3%A2-al-2016
#16
Maurice Göldi, Thomas Schreiner
Slow-wave sleep (SWS) has been ascribed to play a key role in memory consolidation processes (Rasch & Born, 2013). One of the most salient features of SWS is the elevated occurrence of slow oscillations (< 1 Hz). Slow oscillations (SOs) are generated in thalamic and neocortical circuits and comprise alterations between periods of increased excitability (up-states) and hyperpolarized neural silence (down-states) (Contreras & Steriade, 1995). This alternating neural activity spreads throughout the neocortex and also affects other brain regions amongst others the hippocampus (Contreras et al...
December 14, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27966421/-acute-mackerel-induced-sleep-in-a-young-researcher
#17
Mette Calundann Noer
Sleeping disorders are common and they are associated with substantial psychological and physical strain in those affected. We report a case of sudden onset of deep sleep in a 29-year-old Danish woman just after intake of mackerel in tomato sauce. There were no abnormal findings in the physical examination and no suspicion of underlying neurological disease. We hypothesize that the observed association between mackerel intake and deep sleep is causal and we suggest that more research is conducted in order to establish the potential of mackerel in treatment of sleeping disorders...
December 12, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27965558/visualization-of-whole-night-sleep-eeg-from-2-channel-mobile-recording-device-reveals-distinct-deep-sleep-stages-with-differential-electrodermal-activity
#18
Julie A Onton, Dae Y Kang, Todd P Coleman
Brain activity during sleep is a powerful marker of overall health, but sleep lab testing is prohibitively expensive and only indicated for major sleep disorders. This report demonstrates that mobile 2-channel in-home electroencephalogram (EEG) recording devices provided sufficient information to detect and visualize sleep EEG. Displaying whole-night sleep EEG in a spectral display allowed for quick assessment of general sleep stability, cycle lengths, stage lengths, dominant frequencies and other indices of sleep quality...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27938925/oximetry-in-obese-children-with-sleep-disordered-breathing
#19
Melania Evangelisti, Hanaa Shafiek, Jole Rabasco, Martina Forlani, Marilisa Montesano, Mario Barreto, Stijn Verhulst, Maria Pia Villa
BACKGROUND: Obesity is an important risk factor for obstructive sleep apnea syndrome (OSAS), and obese children with OSAS have frequently shown oxygen desaturations when compared with normal-weight children. The aim of our study was to investigate the oximetry characteristics in children with obesity and sleep-disordered breathing (SDB). METHODS: Children referred for suspected OSAS were enrolled in the study. All children underwent sleep clinical record (SCR), pulse oximetry, and polysomnography (PSG)...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27922922/a-sleep-hygiene-and-relaxation-intervention-for-children-with-acute-lymphoblastic-leukemia-a-pilot-randomized-controlled-trial
#20
Sue Zupanec, Heather Jones, Lyndsey McRae, Efrosini Papaconstantinou, Julie Weston, Robyn Stremler
BACKGROUND: Sleep disturbance and fatigue are common and distressing pediatric cancer-related outcomes. Sleep hygiene education and relaxation techniques are recommended to improve sleep in healthy children and adult cancer survivors. No studies have tested these interventions to improve sleep and fatigue for children with acute lymphoblastic leukemia (ALL) in the home setting. OBJECTIVES: The aim of this study is to establish the feasibility and acceptability of a sleep hygiene and relaxation intervention to improve sleep and fatigue for children receiving maintenance chemotherapy for ALL...
December 30, 2016: Cancer Nursing
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