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https://www.readbyqxmd.com/read/28807495/the-colorful-spectrum-of-tourette-syndrome-and-its-medical-surgical-and-behavioral-therapies
#1
Jan Roth
Tourette syndrome (TS) is a common neuropsychiatric disorder, more common in males than females, with onset before age 18. TS is characterized by multiple motor tics and one or more vocal/phonic tics, persisting for more than a year. Tics are unvoluntary, abrupt, rapid, repetitive, but non-rhythmic movements or sounds (vocalizations). They are preceded by an inner urge. Tics can be temporarily suppressed, but this leads to a powerful re-emergence. The performance of tics results in immediate but transient relief...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28805564/deep-brain-stimulation-and-nonmotor-symptoms
#2
Elliot Hogg, Jeffrey Wertheimer, Sarah Graner, Michele Tagliati
Deep brain stimulation (DBS) is currently the treatment of choice for advanced Parkinson's disease (PD). Several brain targets, including the subthalamic nucleus and the globus pallidus internus, have been successfully employed, with excellent motor outcomes. Despite less established knowledge, DBS may be a powerful tool for managing a wide variety of nonmotor symptoms (NMS) in PD patients, either directly or indirectly due to motor benefit or reduction of dopaminergic drug load. After an assessment of global nonmotor outcomes of DBS, as measured by currently available clinical scales and questionnaires, this chapter will address DBS effects on four main NMS categories: neurobehavioral, including cognitive and neuropsychiatric symptoms, autonomic dysfunction, including orthostatic hypotension, constipation, and urinary dysfunction, sleep disturbances, including insomnia, REM sleep behavior disorder, and restless leg syndrome, to conclude with sensory symptoms, mainly focusing on pain...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28790302/formation-and-suppression-of-acoustic-memories-during-human-sleep
#3
Thomas Andrillon, Daniel Pressnitzer, Damien Léger, Sid Kouider
Sleep and memory are deeply related, but the nature of the neuroplastic processes induced by sleep remains unclear. Here, we report that memory traces can be both formed or suppressed during sleep, depending on sleep phase. We played samples of acoustic noise to sleeping human listeners. Repeated exposure to a novel noise during Rapid Eye Movements (REM) or light non-REM (NREM) sleep leads to improvements in behavioral performance upon awakening. Strikingly, the same exposure during deep NREM sleep leads to impaired performance upon awakening...
August 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28777724/active-inference-curiosity-and-insight
#4
Karl J Friston, Marco Lin, Christopher D Frith, Giovanni Pezzulo, J Allan Hobson, Sasha Ondobaka
This article offers a formal account of curiosity and insight in terms of active (Bayesian) inference. It deals with the dual problem of inferring states of the world and learning its statistical structure. In contrast to current trends in machine learning (e.g., deep learning), we focus on how people attain insight and understanding using just a handful of observations, which are solicited through curious behavior. We use simulations of abstract rule learning and approximate Bayesian inference to show that minimizing (expected) variational free energy leads to active sampling of novel contingencies...
August 4, 2017: Neural Computation
https://www.readbyqxmd.com/read/28767471/high-flow-nasal-oxygen-in-patient-with-obstructive-sleep-apnea-undergoing-awake-craniotomy-a-case-report
#5
Jaclyn W M Wong, Amy H S Kong, Sau Yee Lam, Peter Y M Woo
Patients with obstructive sleep apnea are frequently considered unsuitable candidates for awake craniotomy due to anticipated problems with oxygenation, ventilation, and a potentially difficult airway. At present, only a handful of such accounts exist in the literature. Our report describes the novel use of high-flow nasal oxygen therapy for a patient with moderate obstructive sleep apnea who underwent an awake craniotomy under deep sedation. The intraoperative application of high-flow nasal oxygen therapy achieved satisfactory oxygenation, maintained the partial carbon dioxide pressure within a reasonable range even during periods of deep sedation, permitted responsive patient monitoring during mapping, and provided excellent patient and surgeon satisfaction...
August 1, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28754605/train-hard-sleep-well-perceived-training-load-sleep-quantity-and-sleep-stage-distribution-in-elite-level-athletes
#6
Melanie Knufinke, Arne Nieuwenhuys, Sabine A E Geurts, Els I S Møst, Kamiel Maase, Maarten H Moen, Anton M L Coenen, Michiel A J Kompier
OBJECTIVES: Sleep is essential for recovery and performance in elite athletes. While it is generally assumed that exercise benefits sleep, high training load may jeopardize sleep and hence limit adequate recovery. To examine this, the current study assessed objective sleep quantity and sleep stage distributions in elite athletes and calculated their association with perceived training load. DESIGN: Mixed-methods. METHODS: Perceived training load, actigraphy and one-channel EEG recordings were collected among 98 elite athletes during 7 consecutive days of regular training...
July 12, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28726308/the-collateral-venous-system-in-late-pregnancy-a-systematic-review-of-the-literature
#7
REVIEW
Aimee Humphries, Peter Stone, S Ali Mirjalili
INTRODUCTION: Recent literature has reported an association between maternal supine sleep position and stillbirth during late pregnancy. In this position the gravid uterus almost completely obstructs the inferior vena cava. A small number of women experience supine hypotension, thought to be due in part to inadequate collateral venous circulation. The aim of this paper is to review the literature describing the anatomy of the collateral venous system and in particular the azygos system, the abdominal portion of which has not been well studied...
July 20, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28725706/the-effect-of-deep-brain-stimulation-on-the-non-motor-symptoms-of-parkinson-s-disease-a-critical-review-of-the-current-evidence
#8
REVIEW
Mónica M Kurtis, Thadshani Rajah, Luisa F Delgado, Haidar S Dafsari
The benefit of deep brain stimulation (DBS) in controlling the motor symptoms of Parkinson's disease is well established, however, the impact on the non-motor symptoms (NMS) remains to be elucidated, although the growing investigative efforts are promising. This article reviews the reported data and considers the level of evidence available with regard to the effect of DBS on NMS total burden and on the cognitive, neuropsychiatric, sleep, pain, dysautonomic, and weight domains. Multiple case series suggest that DBS improves the burden of NMS by reducing prevalence, intensity, and non-motor fluctuations...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28715343/deep-belief-networks-for-electroencephalography-a-review-of-recent-contributions-and-future-outlooks
#9
Faezeh Movahedi, James L Coyle, Ervin Sejdic
Deep learning, a relatively new branch of machine learning, has been investigated for use in a variety of biomedical applications. Deep learning algorithms have been used to analyze different physiological signals and gain a better understanding of human physiology for automated diagnosis of abnormal conditions. In this manuscript, we provide an overview of deep learning approaches with a focus on deep belief networks in electroencephalography applications. We investigate the state of- the-art algorithms for deep belief networks and then cover the application of these algorithms and their performances in electroencephalographic applications...
July 14, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28702729/improvement-of-the-night-sleep-quality-by-electrocutaneous-subthreshold-stimulation-synchronized-with-the-slow-wave-sleep
#10
Yu V Gulyaev, A S Bugaev, P A Indursky, V M Shakhnarovich, V V Dementienko
Changes in sleep characteristics were studied under the non-wake-up stimulation with current pulses of less than 1 μA on average, applied to the palmar surface skin receptors during Δ-sleep. A significant increase in duration of the first and second cycles of deep sleep has been found, as well as a shorter latent period before the Δ-sleep onset and a longer time of the rapid sleep (REM phase). The sleep structure improvement was accompanied by the reduced reactive anxiety and depression and an increase in subjective physical efficiency...
May 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/28690583/correlating-interictal-spikes-with-sigma-and-delta-dynamics-during-non-rapid-eye-movement-sleep
#11
Frédéric Zubler, Annalisa Rubino, Giorgio Lo Russo, Kaspar Schindler, Lino Nobili
Interictal spikes (IS) are one of the major hallmarks of epilepsy. Understanding the factors promoting or suppressing IS would increase our comprehension of epilepsy and possibly open new avenues for therapy. Sleep strongly influences epileptic activity, and the modulatory effects of the different sleep stages on IS have been studied for decades. However, several aspects are still disputed, in particular the role of sleep spindles and slow waves in the activation of IS during Non-REM sleep. Here, we correlate the rate of IS with quantitative measures derived from stereo-EEG during one Non-REM cycle in 10 patients suffering from drug-resistant epilepsy due to type 2 focal cortical dysplasia...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28690232/-progress-in-sleep-disordered-breathing-in-idiopathic-pulmonary-fibrosis
#12
Ying Zhou, Runxu Song, Danbei Diwu, Yixin Wan
Idiopathic pulmonary fibrosis (IPF) is one of the most common idiopathic interstitial pneumonia. The main symptoms for IPF are dry cough and exertional shortness of breath, which is worsen gradually with the development of pulmonary fibrosis. Patients with IPF often suffer from sleep disordered breathing (SDB). Sleep architecture for these patients including the sleep efficiency, deep sleep, rapid eye movement sleep and arousal index, are changed, which seriously affects the quality of life. In the absence of effective therapies, optimizing the quality of life may become a major therapeutic target for IPF...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28680342/residual-effects-of-eszopiclone-and-placebo-in-healthy-elderly-subjects-a-randomized-double-blind-study
#13
Jun Takahashi, Takashi Kanbayashi, Sachiko Ito Uemura, Youhei Sagawa, Kou Tsutsui, Yuya Takahashi, Yuki Omori, Aya Imanishi, Masahiro Takeshima, Masahiro Satake, Tetsuo Shimizu
Next-day residual effects are a common problem with current hypnotics. The purpose of the present study was to evaluate the residual effects of eszopiclone on the physical and cognitive functions of healthy elderly people in the early morning and the day following drug administration. Four men and six women aged 63-72 years were administered eszopiclone 1 mg or placebo in a randomized, double-blind and crossover design. Measures of objective parameters and subjective ratings were obtained at 4:00, 6:00, and every 2 h from 6:00 to 16:00 hours...
2017: Sleep and Biological Rhythms
https://www.readbyqxmd.com/read/28679286/local-differences-in-computational-sleep-depth-parameters-in-healthy-school-aged-children
#14
Sari-Leena Himanen, Eero Huupponen, Marjukka Jussila, Anna-Maria Lapinlampi, Outi Saarenpää-Heikkilä
OBJECTIVE: Slow wave sleep in children reflects several processes, such as sleep pressure, synaptic density, and cortical maturation. Deep sleep in children is abundant and our aim was to discover whether examining electroencephalography (EEG) mean frequency would help separate these processes. METHODS: Sleep EEG of 28 generally healthy 7- to 11-year-old children (14 first graders, 14 third graders, 14 girls, 14 boys) was analyzed. Median non-rapid eye movement (NREM) sleep EEG frequency (median sleep depth, in Hz) and the amount of computational deep sleep using the thresholds of 2 Hz and 4 Hz (DS2% and DS4%, respectively) were calculated from the frontopolar, central, and occipital EEG derivations...
July 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28678710/deepsleepnet-a-model-for-automatic-sleep-stage-scoring-based-on-raw-single-channel-eeg
#15
Akara Supratak, Hao Dong, Chao Wu, Yike Guo
The present study proposes a deep learning model, named DeepSleepNet, for automatic sleep stage scoring based on raw single-channel EEG. Most of the existing methods rely on hand-engineered features which require prior knowledge of sleep analysis. Only a few of them encode the temporal information such as transition rules, which is important for identifying the next sleep stages, into the extracted features. In the proposed model, we utilize Convolutional Neural Networks to extract timeinvariant features, and bidirectional-Long Short-Term Memory to learn transition rules among sleep stages automatically from EEG epochs...
June 28, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28674771/a-review-of-the-physiology-of-a-survival-expert-of-big-freeze-deep-snow-and-an-empty-stomach-the-boreal-raccoon-dog-nyctereutes-procyonoides
#16
REVIEW
Anne-Mari Mustonen, Petteri Nieminen
The raccoon dog (Nyctereutes procyonoides) is an invasive canid originating from eastern Asia. Here, we review its physiological adaptations to wintering, with an emphasis on northern Europe, where the raccoon dog spends the coldest part of the year in winter sleep. The timing of physiological changes related to wintering is connected to photoperiod by melatonin. In preparation to winter, raccoon dogs display autumnal hyperphagia and fattening probably regulated by the interaction of several peptide hormones...
July 4, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28661013/pain-associated-with-pressure-injury-a-qualitative-study-of-community-based-home-dwelling-individuals
#17
Debra Jackson, Lisa Durrant, Emily Bishop, Helen Walthall, Ria Betteridge, Sarah Gardner, Wendy Coulton, Marie Hutchinson, Stephen Neville, Patricia M Davidson, Kim Usher
AIMS: To provide deep insights into the pain associated with pressure injuries in home-dwelling individuals using narrative accounts. BACKGROUND: Pressure injuries or pressure ulcers are burdensome and costly. Prevalence data, surveys and systematic reviews demonstrate that pain associated with pressure injury is widespread, but voices of home-dwelling patients have remained largely unheard. DESIGN: Concurrent mixed methods case study of a UK community of approximately 50,000 adults...
June 29, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28642284/excitation-of-gabaergic-neurons-in-the-bed-nucleus-of-the-stria-terminalis-triggers-immediate-transition-from-non-rapid-eye-movement-sleep-to-wakefulness-in-mice
#18
Shota Kodani, Shingo Soya, Takeshi Sakurai
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To determine whether the extended amygdala plays a role in sleep-wakefulness regulation, we examined the effects of optogenetic and pharmacogenetic excitation of GABAergic neurons in the bed nucleus of the stria terminalis (GABA(BNST) neurons). Acute optogenetic excitation of these cells during nonrapid eye movement (NREM) sleep resulted in an immediate state transition to wakefulness, whereas stimulation during REM sleep showed no effect on sleep-wakefulness states in male mice...
July 26, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28635658/asperentin-b-a-new-inhibitor-of-the-protein-tyrosine-phosphatase-1b
#19
Jutta Wiese, Hülya Aldemir, Rolf Schmaljohann, Tobias A M Gulder, Johannes F Imhoff
In the frame of studies on secondary metabolites produced by fungi from deep-sea environments we have investigated inhibitors of enzymes playing key roles in signaling cascades of biochemical pathways relevant for the treatment of diseases. Here we report on a new inhibitor of the human protein tyrosine phosphatase 1B (PTP1B), a target in the signaling pathway of insulin. A new asperentin analog is produced by an Aspergillussydowii strain isolated from the sediment of the deep Mediterranean Sea. Asperentin B (1) contains an additional phenolic hydroxy function at C-6 and exhibits an IC50 value against PTP1B of 2 μM in vitro, which is six times stronger than the positive control, suramin...
June 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28634363/long-term-health-outcomes-in-patients-with-prader-willi-syndrome-a-nationwide-cohort-study-in-denmark
#20
E Hedgeman, S P Ulrichsen, S Carter, N C Kreher, K P Malobisky, M M Braun, J Fryzek, M S Olsen
BACKGROUND: Prader-Willi syndrome (PWS) is a rare congenital disease that affects growth, sexual development, cognitive function and behavior. Individuals exhibit food preoccupation and hyperphagia, which may lead to obesity with premature morbidity and mortality. The aim of this work was to evaluate the risk of venous thromboembolisms (VTE), myocardial infarction, pulmonary hypertension, sleep apnea, depression, anxiety and all-cause mortality among persons with PWS as compared to an age- and sex-matched general population cohort...
June 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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