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https://www.readbyqxmd.com/read/29677539/fibromyalgia-and-nutrition-therapeutic-possibilities
#1
REVIEW
Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Jan Aaseth
Fibromyalgia (FM) is a complex chronic condition of unknown etiology, characterized by deep and widespread pain, sleep problems, cognitive impairment, fatigue, and other well-known functional symptoms. Recently, it has been proposed that an imbalance of nutritive components, including essential metal ions and vitamins, might play a critical role in the development of FM. Muscle pain has been associated with deficiencies in amino acids, magnesium, selenium, vitamins B and D, as well as with the harmful effects of heavy metals, such as mercury, cadmium, and lead...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29652699/impact-of-the-glymphatic-system-on-the-kinetic-and-distribution-of-gadodiamide-in-the-rat-brain-observations-by-dynamic-mri-and-effect-of-circadian-rhythm-on-tissue-gadolinium-concentrations
#2
Toshiaki Taoka, Gregor Jost, Thomas Frenzel, Shinji Naganawa, Hubertus Pietsch
OBJECTIVES: The glymphatic system is a recently hypothesized waste clearance system of the brain in which perivascular space constitutes a pathway similar to the lymphatic system in other body regions. Sleep and anesthesia are reported to influence the activity of the glymphatic system. Because rats are nocturnal animals, the glymphatic system is expected to be more active during the day. We attempted to elucidate the influence of the glymphatic system for intravenously injected gadodiamide in the rat brain by 2 experiments...
April 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29624144/pilot-study-of-intracranial-venous-physiology-in-craniosynostosis
#3
Martijn J Cornelissen, Robbin de Goederen, Priya Doerga, Iris Cuperus, Marie-Lise van Veelen, Maarten Lequin, Paul Govaert, Irene M J Mathijssen, Jeroen Dudink, Robert C Tasker
OBJECTIVE In addition to craniocerebral disproportion, other factors, such as Chiari malformation type I, obstructive sleep apnea, and venous outflow obstruction, are considered to have a role in the occurrence of intracranial hypertension in craniosynostosis. This pilot study examined cerebral venous flow velocity to better characterize the complex intracranial venous physiology of craniosynostosis. METHODS The authors performed a prospective cohort study of craniosynostosis patients (n = 34) referred to a single national (tertiary) craniofacial unit...
April 6, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29605589/patients-perceptions-of-sleep-in-a-critical-care-unit
#4
L Carrera-Hernández, E Aizpitarte-Pejenaute, N Zugazagoitia-Ciarrusta, R Goñi-Viguria
INTRODUCTION AND OBJECTIVES: Patients' sleep can be disturbed during their stay in an Intensive Care Unit. Many factors can explain this disturbance, both within the ICU environment and caused by patients' illnesses. There is evidence that patients' sleep can be improved within ICUs. The aim of this study is to describe patientś perceptions of a night's sleep and develop a care plan that promotes a night's sleep. METHODOLOGY: A prospective descriptive study was performed in the ICU of a training hospital...
March 28, 2018: Enfermería Intensiva
https://www.readbyqxmd.com/read/29599709/caffeine-and-modafinil-ameliorate-the-neuroinflammation-and-anxious-behavior-in-rats-during-sleep-deprivation-by-inhibiting-the-microglia-activation
#5
Meetu Wadhwa, Garima Chauhan, Koustav Roy, Surajit Sahu, Satyanarayan Deep, Vishal Jain, Krishna Kishore, Koushik Ray, Lalan Thakur, Usha Panjwani
Background : Sleep deprivation (SD) plagues modern society due to the professional demands. It prevails in patients with mood and neuroinflammatory disorders. Although growing evidence suggests the improvement in the cognitive performance by psychostimulants during sleep-deprived conditions, the impending involved mechanism is rarely studied. Thus, we hypothesized that mood and inflammatory changes might be due to the glial cells activation induced modulation of the inflammatory cytokines during SD, which could be improved by administering psychostimulants...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29598896/effects-of-hammock-positioning-in-behavioral-status-vital-signs-and-pain-in-preterms-a-case-series-study
#6
Valdecira Rodrigues de Jesus, Pricila Mara Novais de Oliveira, Vivian Mara Gonçalves de Oliveira Azevedo
BACKGROUND: The hammock positioning within the incubators simulates the intrauterine environment, however, there is little evidence of its benefits and possible risks. OBJECTIVES: The aim of this study was to assess the effects of hammock positioning on behavioral status, vital signs, and pain in very low birth weight preterm newborns. METHODS: This is a quasi-experimental/case series study in which premature infants (<1500g) were positioned in supine for one hour in a hammock...
March 15, 2018: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29581380/effects-of-ageing-on-cortical-neural-dynamics-and-local-sleep-homeostasis-in-mice
#7
Laura E McKillop, Simon P Fisher, Nanyi Cui, Stuart N Peirson, Russell G Foster, Keith A Wafford, Vladyslav V Vyazovskiy
Healthy ageing is associated with marked effects on sleep, including its daily amount and architecture, as well as the specific electroencephalogram (EEG) oscillations. Neither the neurophysiological underpinnings, nor the biological significance of these changes are understood, and crucially the question remains whether ageing is associated with reduced sleep need or a diminished capacity to generate sufficient sleep. Here we tested the hypothesis that ageing may affect local cortical networks, disrupting the capacity to generate and sustain sleep oscillations, and with it the local homeostatic response to sleep loss...
March 26, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29576872/pfo-closure-in-high-risk-patient-with-paradoxical-arterial-embolism-deep-vein-thrombosis-pulmonary-embolism-and-factor-v-leiden-genetic-mutation
#8
A Parikh, T P Vacek
Occurrence of paradoxical arterial embolism may cause the first symptoms in patients with a coexisting hypercoagulable state and patent foramen ovale (PFO). This can result in significant morbidity and mortality depending on the location of the embolism. The risks and benefits of closure of small PFOs have not been well elucidated in prior studies. We describe a patient with a history of Factor V Leiden heterozygosity who presented with left arm pain secondary to arterial embolism. The patient was a 51-year-old male who initially presented to the emergency department after awaking from sleep with progressive, severe, burning left arm pain...
March 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29557546/whole-brain-mapping-of-direct-inputs-to-and-axonal-projections-from-gabaergic-neurons-in-the-parafacial-zone
#9
Yun-Ting Su, Meng-Yang Gu, Xi Chu, Xiang Feng, Yan-Qin Yu
The GABAergic neurons in the parafacial zone (PZ) play an important role in sleep-wake regulation and have been identified as part of a sleep-promoting center in the brainstem, but the long-range connections mediating this function remain poorly characterized. Here, we performed whole-brain mapping of both the inputs and outputs of the GABAergic neurons in the PZ of the mouse brain. We used the modified rabies virus EnvA-ΔG-DsRed combined with a Cre/loxP gene-expression strategy to map the direct monosynaptic inputs to the GABAergic neurons in the PZ, and found that they receive inputs mainly from the hypothalamic area, zona incerta, and parasubthalamic nucleus in the hypothalamus; the substantia nigra, pars reticulata and deep mesencephalic nucleus in the midbrain; and the intermediate reticular nucleus and medial vestibular nucleus (parvocellular part) in the pons and medulla...
March 20, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29549733/combining-deep-residual-neural-network-features-with-supervised-machine-learning-algorithms-to-classify-diverse-food-image-datasets
#10
Patrick McAllister, Huiru Zheng, Raymond Bond, Anne Moorhead
Obesity is increasing worldwide and can cause many chronic conditions such as type-2 diabetes, heart disease, sleep apnea, and some cancers. Monitoring dietary intake through food logging is a key method to maintain a healthy lifestyle to prevent and manage obesity. Computer vision methods have been applied to food logging to automate image classification for monitoring dietary intake. In this work we applied pretrained ResNet-152 and GoogleNet convolutional neural networks (CNNs), initially trained using ImageNet Large Scale Visual Recognition Challenge (ILSVRC) dataset with MatConvNet package, to extract features from food image datasets; Food 5K, Food-11, RawFooT-DB, and Food-101...
February 17, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29523391/value-of-ictal-and-interictal-epileptiform-discharges-and-high-frequency-oscillations-for-delineating-the-epileptogenic-zone-in-patients-with-focal-cortical-dysplasia
#11
C Cuello-Oderiz, N von Ellenrieder, R Sankhe, A Olivier, J Hall, F Dubeau, J Gotman
OBJECTIVES: There are different neurophysiological markers of the Epileptogenic Zone (EZ), but their sensitivity and specificity for the EZ is not known in Focal Cortical Dysplasia (FCD) patients. METHODS: We studied patients with FCD who underwent stereoelectroencephalography (SEEG) and surgery. We marked in the SEEG: (a) typical and atypical interictal epileptiform patterns, (b) ictal onset patterns, and (c) rates of ripples (80-250 Hz) and fast ripples (FRs) (>250 Hz)...
February 22, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29498771/single-unit-activity-of-periaqueductal-gray-and-deep-mesencephalic-nucleus-neurons-involved-in-sleep-stage-switching-in-the-mouse
#12
K Sakai
A total of 668 single units were recorded in the mouse periaqueductal gray (PAG) and adjacent deep mesencephalic nucleus (DpMe) in order to determine their role in the switching of sleep-wake states, i.e. wakefulness (W), slow-wave sleep (SWS), and paradoxical (or rapid eye movement) sleep (PS) in general, and, in particular, to determine whether PS-on and PS-off neurons involved in PS state switching are present in these structures and to identify neuronal substrates for the SWS-PS switching mediated by DpMe neurons...
March 2, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29492547/are-slow-waves-of-intracranial-pressure-suppressed-by-general-anaesthesia
#13
Despina Afroditi Lalou, Marek Czosnyka, Joseph Donnelly, Andrea Lavinio, John D Pickard, Matthew Garnett, Zofia Czosnyka
OBJECTIVES: Slow waves of intracranial pressure (ICP) are spontaneous oscillations with a frequency of 0.3-4 cycles/min. They are often associated with pathological conditions, following vasomotor activity in the cranial enclosure. This study quantifies the effects of general anaesthesia (GA) on the magnitude of B-waves compared with natural sleep and the conscious state. MATERIALS AND METHODS: Four groups of 30 patients each were formed to assess the magnitude of slow waves...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29486170/timing-of-eating-in-adults-across-the-weight-spectrum-metabolic-factors-and-potential-circadian-mechanisms
#14
Kelly C Allison, Namni Goel
Timing of eating is recognized as a significant contributor to body weight regulation. Disruption of sleep-wake cycles from a predominantly diurnal (daytime) to a delayed (evening) lifestyle leads to altered circadian rhythms and metabolic dysfunction. This article reviews current evidence for timed and delayed eating in individuals of normal weight and those with overweight or obesity: some findings indicate a benefit of eating earlier in the daytime on weight and/or metabolic outcomes, although the findings have not been uniformly consistent, and more rigorous and longer-duration studies are needed...
February 24, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29479862/positive-association-of-plasma-leptin-with-sleep-quality-in-obese-type-2-diabetes-patients
#15
Tomoe Hirota, Tomoaki Morioka, Koichiro Yoda, Norikazu Toi, Noriyuki Hayashi, Saori Maruo, Yuko Yamazaki, Masafumi Kurajoh, Koka Motoyama, Shinsuke Yamada, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba
AIMS/INTRODUCTION: Poor sleep quality is associated with obesity and diabetes. The adipocyte-derived hormone, leptin, was recently shown to underlie the link between abnormal sleep and obesity. We aimed to investigate the association between leptin and sleep quality in type 2 diabetes patients. MATERIALS AND METHODS: In the present cross-sectional study, we studied 182 type 2 diabetes patients, among whom 113 were diagnosed with obesity (body mass index ≥25 kg/m2 )...
February 26, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29464512/feasibility-of-continuous-sedation-monitoring-in-critically-ill-intensive-care-unit-patients-using-the-neurosense-wav-cns-index
#16
Nicholas West, Paul B McBeth, Sonia M Brodie, Klaske van Heusden, Sarah Sunderland, Guy A Dumont, Donald E G Griesdale, J Mark Ansermino, Matthias Görges
Sedation in the intensive care unit (ICU) is challenging, as both over- and under-sedation are detrimental. Current methods of assessment, such as the Richmond Agitation Sedation Scale (RASS), are measured intermittently and rely on patients' behavioral response to stimulation, which may interrupt sleep/rest. A non-stimulating method for continuous sedation monitoring may be beneficial and allow more frequent assessment. Processed electroencephalography (EEG) monitors have not been routinely adopted in the ICU...
February 20, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29462275/excitation-of-cortical-nnos-nk1r-neurons-by-hypocretin-1-is-independent-of-sleep-homeostasis
#17
Rhîannan H Williams, Sarah W Black, Alexia M Thomas, Juliette Piquet, Bruno Cauli, Thomas S Kilduff
We have proposed that cortical nNOS/NK1R interneurons have a role in sleep homeostasis. The hypocretins (orexins) are wake-promoting neuropeptides and hypocretin/orexin (Hcrt) neurons project to the cortex. Hcrt peptides affect deep layer cortical neurons, and Hcrt receptor 1 (Hcrtr1; Ox1r) mRNA is expressed in cortical nNOS/NK1R cells. Therefore, we investigated whether Hcrt neuron stimulation affects cingulate cortex nNOS/NK1R neurons. Bath application of HCRT1/orexin-A evoked an inward current and membrane depolarization in most nNOS/NK1R cells which persisted in tetrodotoxin; optogenetic stimulation of Hcrt terminals expressing channelrhodopsin-2 confirmed these results, and pharmacological studies determined that HCRTR1 mediated these responses...
February 16, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29458748/does-continuous-positive-airway-pressure-treatment-affect-autonomic-nervous-system-in-patients-with-severe-obstructive-sleep-apnea
#18
Francesca Izzi, Fabio Placidi, Claudio Liguori, Benedetta Lauretti, Girolama A Marfia, Antonio Pisani, Nicola B Mercuri, Camilla Rocchi
OBJECTIVE: This study is aimed at evaluating whether Continuous Positive Airway Pressure treatment (CPAP) may affect autonomic nervous system (ANS) in male patients with severe obstructive sleep apnea (OSAS). METHODS: We compared autonomic symptoms of de novo severe OSAS patients, OSAS patients on chronic CPAP treatment and healthy controls, using the Scales for Outcome in Parkinson disease-Autonomic (SCOPA-AUT) questionnaire. All groups underwent cardiovascular function tests including head-up tilt test (HUTT), Valsalva maneuver, deep breathing, hand grip and cold face tests...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29453207/hippocampal-ripple-oscillations-and-inhibition-first-network-models-frequency-dynamics-and-response-to-gaba-modulators
#19
José R Donoso, Dietmar Schmitz, Nikolaus Maier, Richard Kempter
Hippocampal ripples are involved in memory consolidation, but the mechanisms underlying their generation remain unclear. Models relying on interneuron networks in the CA1 region disagree on the predominant source of excitation to interneurons: either 'direct', via the Schaffer collaterals that provide feedforward input from CA3 to CA1, or 'indirect', via the local pyramidal cells in CA1, which are embedded in a recurrent excitatory-inhibitory network. Here, we used physiologically constrained computational models of basket-cell networks to investigate how they respond to different conditions of transient, noisy excitation...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29451501/transitions-in-physiological-coupling-between-heartbeat-and-pulse-across-sleep-stages
#20
Qianli D Y Ma, Changjuan Ji, Huanhuan Xie, Kai Yin, Zhen Ma, Chunhua Bian
The aim of this study is to investigate the coupling behavior between heartbeat and pulse of blood flow at different sleep stages, and to explore the feasibility of using this coupling strength for automatic sleep staging.&#13; Approach: The electrocardiogram (ECG) and photoplethysmography (PPG) signals are recorded during sleep, and R-wave-to-R-wave intervals (RRI) and Pulse-to-Pulse intervals (PPI) are extracted respectively. The detrended cross-correlation analysis (DCCA) is applied to quantify long-range cross correlations between the RRIs and PPIs across sleep stages...
February 16, 2018: Physiological Measurement
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