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Multiple Chemical Sensitivities

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https://www.readbyqxmd.com/read/28330782/preparative-two-dimensional-separations-involving-liquid-liquid-chromatography
#1
Léa Marlot, Karine Faure
The increasing performances of analytical techniques, especially two-dimensional liquid chromatography hyphenated with highly sensitive detectors, allow discovery of new targeted compounds in highly complex samples, whether biomarkers in environmental effluents, natural metabolomes in natural products or unknown impurities in synthetic chemical process. While structural identification can usually be achieved through mass spectrometry and databases, it can be useful to confirm the potential structure via NMR analysis and/or to obtain standard reference material for quantitative purposes, incentive for the production of μg to mg of new target compounds...
March 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28326907/skin-sensitizers-in-cosmetics-and-beyond-potential-multiple-mechanisms-of-action-and-importance-of-t-cell-assays-for-in-vitro-screening
#2
Stanislav Vukmanović, Nakissa Sadrieh
Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity (DTH) reaction induced by repeated contact with sensitizers. The ability of a chemical to act as a sensitizer has most frequently been tested in animals. As the use of animals for these purposes is gradually and globally being phased out, there is a need for reliable in vitro surrogate assays. Currently proposed in vitro assays are designed to test four key events of the adverse outcome pathway (AOP) involving covalent modification of self-proteins by sensitizers (haptenation) and presentation of new antigens (hapten/carrier complexes) to the immune system...
March 22, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28323368/biotic-interactions-modify-multiple-stressor-effects-on-juvenile-brown-trout-in-an-experimental-stream-food-web
#3
Andreas Bruder, Romana K Salis, Peter E Jones, Christoph D Matthaei
Agricultural land use results in multiple stressors affecting stream ecosystems. Flow reduction due to water abstraction, elevated levels of nutrients and chemical contaminants are common agricultural stressors worldwide. Concurrently, stream ecosystems are also increasingly affected by climate change. Interactions among multiple co-occurring stressors result in biological responses that cannot be predicted from single-stressor effects (i.e. synergisms and antagonisms). At the ecosystem level, multiple-stressor effects can be further modified by biotic interactions (e...
March 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28316094/predicting-herbicide-mixture-effects-on-multiple-algal-species-using-mixture-toxicity-models
#4
Takashi Nagai
The validity of the application of mixture toxicity models, concentration addition (CA) and independent action (IA), to species sensitivity distribution (SSD) for calculation of multi-substance potentially affected fraction (msPAF) was examined in laboratory experiments. Toxicity assays of herbicide mixtures using 5 species of periphytic algae were conducted. Two mixture experiments were designed: a mixture of 5 herbicides with similar mode of action (MoA) and a mixture of 5 herbicides with dissimilar MoA, corresponding to the assumptions of the CA and IA models, respectively...
March 18, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28299695/development-of-novel-piezoelectric-biosensor-using-pzt-ceramic-resonator-for-detection-of-cancer-markers
#5
Li Su, Chi-Chun Fong, Pik-Yuan Cheung, Mengsu Yang
A novel biosensor based on piezoelectric ceramic resonator was developed for direct detection of cancer markers in the study. For the first time, a commercially available PZT ceramic resonator with high resonance frequency was utilized as transducer for a piezoelectric biosensor. A dual ceramic resonators scheme was designed wherein two ceramic resonators were connected in parallel: one resonator was used as the sensing unit and the other as the control unit. This arrangement minimizes environmental influences including temperature fluctuation, while achieving the required frequency stability for biosensing applications...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28295128/medically-unexplained-physical-symptoms-mups-among-adults-in-canada-comorbidity-health-care-use-and-employment
#6
Jungwee Park, Heather Gilmour
Based on data from the 2014 Canadian Community Health Survey and the 2012 Canadian Community Health Survey-Mental Health, this study provides estimates of the prevalence of medically unexplained physical symptoms (MUPS) in the household population aged 25 or older. MUPS are examined in relation to sociodemographic characteristics, physical and mental comorbidity, health care use and unmet needs, labour force participation and productivity. In 2014, 5.5% of Canadian adults-an estimated 1.3 million - reported having chronic fatigue syndrome (1...
March 15, 2017: Health Reports
https://www.readbyqxmd.com/read/28286422/hypersensitivity-pneumonitis-a-complex-lung-disease
#7
REVIEW
Gian Galeazzo Riario Sforza, Androula Marinou
Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitium, due to a delayed allergic reaction. Such reaction is secondary to a repeated and prolonged inhalation of different types of organic dusts or other substances to which the patient is sensitized and hyper responsive, primarily consisting of organic dusts of animal or vegetable origin, more rarely from chemicals...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28283271/multiple-chemical-sensitivity-genotypic-characterization-nutritional-status-and-quality-of-life-in-52-patients
#8
Viviana Loria-Kohen, Helena Marcos-Pasero, Rocío de la Iglesia, Elena Aguilar-Aguilar, Isabel Espinosa-Salinas, Jesús Herranz, Ana Ramírez de Molina, Guillermo Reglero
BACKGROUND AND OBJECTIVES: Multiple chemical sensitivity (MCS) is a chronic, multisystem syndrome of unknown etiology. The aim of the present study was to describe the nutritional status and quality of life of patients suffering from MCS, as well as to identify potential polymorphisms associated with this illness. PATIENTS AND METHODS: A cross-sectional, descriptive study was performed on patients with a diagnosis of MCS. Data on anthropometric and body composition variables, hand muscle strength and quality of life were collected...
March 7, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28279161/methylated-site-display-msd-aflp-a-sensitive-and-affordable-method-for-analysis-of-cpg-methylation-profiles
#9
Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Hisaka Kurita, Chiharu Tohyama, Seiichiroh Ohsako
BACKGROUND: It has been pointed out that environmental factors or chemicals can cause diseases that are developmental in origin. To detect abnormal epigenetic alterations in DNA methylation, convenient and cost-effective methods are required for such research, in which multiple samples are processed simultaneously. We here present methylated site display (MSD), a unique technique for the preparation of DNA libraries. By combining it with amplified fragment length polymorphism (AFLP) analysis, we developed a new method, MSD-AFLP...
March 9, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28275316/cohort-description-the-danish-study-of-functional-disorders
#10
Thomas Meinertz Dantoft, Jeanette Frost Ebstrup, Allan Linneberg, Sine Skovbjerg, Anja Lykke Madsen, Jesper Mehlsen, Louise Brinth, Lene Falgaard Eplov, Tina Wisbech Carstensen, Andreas Schroder, Per Klausen Fink, Erik Lykke Mortensen, Torben Hansen, Oluf Pedersen, Torben Jørgensen
The Danish study of Functional Disorders (DanFunD) cohort was initiated to outline the epidemiology of functional somatic syndromes (FSS) and is the first larger coordinated epidemiological study focusing exclusively on FSS. FSS are prevalent in all medical settings and can be defined as syndromes that, after appropriate medical assessment, cannot be explained in terms of a conventional medical or surgical disease. FSS are frequent and the clinical importance varies from vague symptoms to extreme disability...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28271209/tgf-%C3%AE-1-impairs-mechanosensation-of-human-osteoblasts-via-hdac6-mediated-shortening-and-distortion-of-primary-cilia
#11
Sabrina Ehnert, Vrinda Sreekumar, Romina H Aspera-Werz, Sahar O Sajadian, Elke Wintermeyer, Gunther H Sandmann, Christian Bahrs, Jan G Hengstler, Patricio Godoy, Andreas K Nussler
Transforming growth factor β (TGF-β) is a critical regulator of bone density owing to its multiple effects on cell growth and differentiation. Recently, we have shown that TGF-β1 effectively blocks bone morphogenetic protein (BMP) induced maturation of osteoblasts by upregulating histone deacetylase (HDAC) activity. The current study aimed at investigating the effect of rhTGF-β1 treatment on the expression of specific HDACs and their cellular effects, e.g., microtubule structures (primary cilia) and mechanosensation...
March 7, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28270582/bacteria-getting-into-shape-genetic-determinants-of-e-%C3%A2-coli-morphology
#12
Shawn French, Jean-Philippe Côté, Jonathan M Stokes, Ray Truant, Eric D Brown
Perturbation of cellular processes is a prevailing approach to understanding biology. To better understand the complicated biology that defines bacterial shape, a sensitive, high-content platform was developed to detect multiple morphological defect phenotypes using microscopy. We examined morphological phenotypes across the Escherichia coli K-12 deletion (Keio) collection at the mid-exponential growth phase, revealing 111 deletions perturbing shape. Interestingly, 64% of these were uncharacterized mutants, illustrating the complex nature of shape maintenance and regulation in bacteria...
March 7, 2017: MBio
https://www.readbyqxmd.com/read/28265985/analytical-determination-of-auxins-and-cytokinins
#13
Petre I Dobrev, Klára Hoyerová, Jan Petrášek
Parallel determination of auxin and cytokinin levels within plant organs and tissues represents an invaluable tool for studies of their physiological effects and mutual interactions. Thanks to their different chemical structures, auxins, cytokinins and their metabolites are often determined separately, using specialized procedures of sample purification, extraction, and quantification. However, recent progress in the sensitivity of analytical methods of liquid chromatography coupled to mass spectrometry (LC-MS) allows parallel analysis of multiple compounds...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28263844/a-high-throughput-bioluminescent-assay-to-monitor-the-deamidation-of-asparagine-and-isomerization-of-aspartate-residues-in-therapeutic-proteins-and-antibodies
#14
Kevin Hsiao, Juliano Alves, Rushikesh Patel, Monica Adams, Vishal Nashine, Said Goueli
Since the introduction of Herceptin and Rituximab in 1986 therapeutic antibodies have gained tremendous momentum in treatment of broad range of several diseases such as cancer and inflammation. Selection of the clinical candidate mAb usually starts with large-scale in vitro screening and profiling of multiple mAbs to identify candidates that show high in vitro or in vivo activity, and thus it is necessarily to identify and eliminate potentially unstable mAbs during the lead selection process. Antibodies undergo a variety of degradation reactions which may result in compromised bioactivity and safety profile...
March 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28262728/chemical-or-genetic-pin1-inhibition-exerts-potent-anticancer-activity-against-hepatocellular-carcinoma-by-blocking-multiple-cancer-driving-pathways
#15
Xin-Hua Liao, Arina Li Zhang, Min Zheng, Mei-Qing Li, Champ Peng Chen, Huijuan Xu, Qing-Song Chu, Dayun Yang, Wenxian Lu, Ting-Fen Tsai, Hekun Liu, Xiao Zhen Zhou, Kun Ping Lu
Hepatocellular carcinoma (HCC) is one of the most prevalent and malignant cancers with high inter- and intra-tumor heterogeneity. A central common signaling mechanism in cancer is proline-directed phosphorylation, which is further regulated by the unique proline isomerase Pin1. Pin1 is prevalently overexpressed in human cancers including ~70% of HCC, and promotes tumorigenesis by activating multiple cancer-driving pathways. However, it was challenging to evaluate the significance of targeting Pin1 in cancer treatment until the recent identification of all-trans retinoic acid (ATRA) as a Pin1 inhibitor...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259582/development-of-passive-samplers-for-in-situ-measurement-of-pyrethroid-insecticides-in-surface-water
#16
Jiaying Xue, Chunyang Liao, Jie Wang, Zachary Cryder, Tianbo Xu, Fengmao Liu, Jay Gan
Pyrethroid insecticides are widely used in urban environments, and their occurrence has been recently associated with aquatic toxicity in urban surface streams. Synthetic pyrethroids are strongly hydrophobic compounds, highlighting the importance of the freely dissolved concentration (Cfree), rather than the total chemical concentration, for better prediction of potential effects in aquatic ecosystems. The goal of this study was to develop a simple, robust and field-applicable passive sampling methodology that may be used for in situ monitoring of trace levels of pyrethroids in surface water...
March 1, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28258661/polymerization-mode-of-self-adhesive-dual-cured-dental-resin-cements-light-cured-through-various-restorative-materials
#17
Ji Suk Shim, Jeong Kyung Kang, Nayansi Jha, Jae Jun Ryu
OBJECTIVE: The aim of this study was to investigate the polymerization mode of self-adhesive, dual-cured resin cements light-cured through overlying materials with different degree of translucency by measuring the degree of conversion (DC). MATERIALS AND METHODS: Three kinds of self-adhesive, dual-cured resin cements (G-CEM LinkAce(TM) , Maxcem Elite(TM) , and BisCem(®) ) were light-cured through three different restorative materials that included porcelain-fused metal (PFM), zirconia, and lithium disilicate...
March 4, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28252167/prediction-of-phosphorylation-sites-based-on-the-integration-of-multiple-classifiers
#18
R Z Han, D Wang, Y H Chen, L K Dong, Y L Fan
Phosphorylation is an important part of post-translational modifications of proteins, and is essential for many biological activities. Phosphorylation and dephosphorylation can regulate signal transduction, gene expression, and cell cycle regulation in many cellular processes. Phosphorylation is extremely important for both basic research and drug discovery to rapidly and correctly identify the attributes of a new protein phosphorylation sites. Moreover, abnormal phosphorylation can be used as a key medical feature related to a disease in some cases...
February 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28248487/practical-stereochemistry
#19
Richard M Kellogg
The relationship between fundamental and applied is often uneasy, particularly in modern political climates. A familiar political view, aimed negatively at the scientific community, is that the former is a waste of money whereas the latter gives value for investment. The answer that fundamental is required as the basis for practical suffers from the fact that the timelines between fundamental and practical are often long and the routes contorted and unexpected. This has been my experience. In this Account, examples are given from the research in which I have been involved wherein quite fundamental considerations have led to various applications...
March 1, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28248097/assessing-model-characterization-of-single-source-secondary-pollutant-impacts-using-2013-senex-field-study-measurements
#20
Kirk R Baker, Matthew C Woody
Aircraft measurements made downwind from specific coal fired power plants during the 2013 Southeast Nexus field campaign provide a unique opportunity to evaluate single source photochemical model predictions of both O3 and secondary PM2.5 species. The model did well at predicting downwind plume placement. The model shows similar patterns of an increasing fraction of PM2.5 sulfate ion to the sum of SO2 and PM2.5 sulfate ion by distance from the source compared with ambient based estimates. The model was less consistent in capturing downwind ambient based trends in conversion of NOX to NOY from these sources...
March 1, 2017: Environmental Science & Technology
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