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Multiple Chemical Sensitivities

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https://www.readbyqxmd.com/read/28812353/dopamine-incorporated-dual-bioactive-electroactive-shape-memory-polyurethane-elastomers-with-physiological-shape-recovery-temperature-high-stretchability-and-enhanced-c2c12-myogenic-differentiation
#1
Xin Zhao, Ruonan Dong, Baolin Guo, Peter X Ma
Soft tissue engineering needs elastic biomaterials not only mimicking the elasticity of soft tissue but also possessing multiple bioactivity to promote cell adhesion, proliferation and differentiation, which still remains ongoing challenges. Herein, we synthesized a series of dopamine-incorporated dual bioactive electroactive shape memory polyurethane elastomers by combining the properties of elastomeric poly(citric acid-co-polycaprolactone) (CA-PCL) polyurethane elastomer, bioactive dopamine (DA) and electroactive aniline hexamer (AH)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28796633/developing-the-regulatory-utility-of-the-exposome-mapping-exposures-for-risk-assessment-through-lifestage-exposome-snapshots-lens
#2
Rachel M Shaffer, Marissa N Smith, Elaine M Faustman
BACKGROUND: Exposome-related efforts aim to document the totality of human exposures across the lifecourse. This field has advanced rapidly in recent years but lacks practical application to risk assessment, particularly for children's health. OBJECTIVES: Our objective was to apply the exposome to children's health risk assessment by introducing the concept of Lifestage Exposome Snapshots (LEnS). Case studies are presented to illustrate the value of the framework...
August 7, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28780855/direct-surface-and-droplet-microsampling-for-electrospray-ionization-mass-spectrometry-analysis-with-an-integrated-dual-probe-microfluidic-chip
#3
Cong-Min Huang, Ying Zhu, Di-Qiong Jin, Ryan T Kelly, Qun Fang
Ambient mass spectrometry (MS) has revolutionized the way of MS analysis and broadened its application in various fields. This paper describes the use of microfluidic techniques to simplify the setup and improve the functions of ambient MS by integrating the sampling probe, electrospray emitter probe, and online mixer on a single glass microchip. Two types of sampling probes, including a parallel-channel probe and a U-shaped channel probe, were designed for dry-spot and liquid-phase droplet samples, respectively...
August 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28770050/resource-allocation-tradeoffs-in-caddisflies-facing-multiple-stressors
#4
Francisco Correa-Araneda, Ana Basaguren, Roberto T Abdala-Díaz, Alan Mosele Tonin, Luz Boyero
The replacement of native forests by exotic tree monocultures, such as those of Eucalyptus, decreases the quality of leaf litter inputs to streams and often reduces riparian cover, which can elevate water temperature. The combined effects of these stressors on the survival and performance of detritivores may be important, as detritivore species loss leads to reduced litter breakdown, a key ecosystem process. Potential loss of cased caddisfly larvae is of particular concern because they are the predominant detritivores in many streams, they are sensitive to warming, and they expend energy on building and carrying their cases, which may be an added burden under times of stress...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28769919/cellular-response-to-ciprofloxacin-in-low-level-quinolone-resistant-escherichia-coli
#5
Jesús Machuca, Esther Recacha, Alejandra Briales, Paula Díaz-de-Alba, Jesús Blazquez, Álvaro Pascual, José-Manuel Rodríguez-Martínez
Bactericidal activity of quinolones has been related to a combination of DNA fragmentation, reactive oxygen species (ROS) production and programmed cell death (PCD) systems. The underlying molecular systems responsible for reducing bactericidal effect during antimicrobial therapy in low-level quinolone resistance (LLQR) phenotypes need to be clarified. To do this and also define possible new antimicrobial targets, the transcriptome profile of isogenic Escherichia coli harboring quinolone resistance mechanisms in the presence of a clinical relevant concentration of ciprofloxacin was evaluated...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28767220/engineering-intracellularly-retained-gaussia-luciferase-reporters-for-improved-biosensing-and-molecular-imaging-applications
#6
Shuchi Gaur, Aarohi Bhargava-Shah, Sharon Hori, Rayhaneh Afjei, Thillai V Sekar, Sanjiv S Gambhir, Tarik F Massoud, Ramasamy Paulmurugan
Gaussia luciferase (GLUC) is a bioluminescent reporter protein of increasing importance. As a secretory protein, it has increased sensitivity in vitro and in vivo (∼20 000-fold, and ∼1000-fold, respectively) over its competitor, secreted alkaline phosphatase. Unfortunately, this same advantageous secretory nature of GLUC limits its usefulness for many other possible intracellular applications, e.g., imaging signaling pathways in intact cells, in vivo imaging, and in developing molecular imaging biosensors to study protein-protein interactions and protein folding...
August 10, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28766982/serum-met-5-enkephalin-levels-are-reduced-in-multiple-sclerosis-and-restored-by-low-dose-naltrexone
#7
Michael D Ludwig, Ian S Zagon, Patricia J McLaughlin
Low-dose naltrexone is a widely used off-label therapeutic prescribed for a variety of immune-related disorders. The mechanism underlying low-dose naltrexone's efficacy for fatigue, Crohn's disease, fibromyalgia, and multiple sclerosis is, in part, intermittent blockade of opioid receptors followed by upregulation of endogenous opioids. Short, intermittent blockade by naltrexone specifically blocks the opioid growth factor receptor resulting in biofeedback events that increase production of the endogenous opioid growth factor (OGF) (chemically termed [Met(5)]-enkephalin) facilitating interactions between opioid growth factor and opioid growth factor receptor that ultimately, result in inhibited cell proliferation...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28761264/a-case-report-of-verruca-vulgaris-on-basis-of-alopecia-areata-successfully-treated-with-diphenylcyclopropenone
#8
Tugba Kevser Uzuncakmak, Mahmut Can Koska, Ayşe Serap Karadağ, Necmettin Akdeniz
Alopecia areata is an autoimmune skin disease which is usually characterized by patchy hair loss in effected regions. Diagnosis usually based on clinical findings and main treatment options include topical, intralesional, systemic corticosteroids, and topical immunotherapy. Verruca vulgaris is an infectious disease caused by human papillomavirus which is usually characterized by well-marginated hyperkeratotic papules or plaques. There are several treatment modalities such as physical and chemical destruction and topical immunotherapy...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28758600/current-strategies-to-improve-the-target-of-cell-penetrating-peptides-used-for-antitumor-therapeutics
#9
Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He, Peng Zhang
Cell penetrating peptides (CPPs) equipped with a high penetrating ability are used as a promising tool to gain access to the cell interior, cross the cell membrane and deliver bioactive small or macromolecular cargos into the cytoplasm or nucleus. The superiority of wide range of applications, high transport efficiency and low biological toxicity make them particularly desirable in laboratory or clinical studies. Previous studies have shown that their non-selectivity and reaction with proteins in plasma hamper their application for tumor therapy, which might adversely affect the treatment effect and even induce some side effects...
July 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28752760/binary-nanoparticle-graphene-hybrid-structure-based-highly-sensitive-biosensing-platform-for-norovirus-like-particle-detection
#10
Jaewook Lee, Kenshin Takemura, Chika Nozaki Kato, Tetsuro Suzuki, Enoch Y Park
Nanoparticle (NP)-decorated carbon nanotubes or graphenes (GRPs) have attracted attention because of their synergic properties such as enhanced electrical conductivity, magneto-optical effect, and plasmon resonance energy transfer. These hybrid carbon nanomaterials are widely used in sensing platforms to monitor target biomolecules, gases, and chemicals. In this study, binary nanoparticles, specifically gold (Au)/magnetic nanoparticle (MNP)-decorated graphenes (GRPs), were applied in a virus-sensing platform...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748460/principles-and-methods-of-immunohistochemistry
#11
José A Ramos-Vara
Immunohistochemical techniques detect antigens in tissue sections by means of immunological and chemical reactions. This technique is highly sensitive and specific and can detect a wide variety of antigens in multiple animal species. This chapter reviews common immunohistochemical methods used in the characterization of normal and pathologic tissue and the reagents used. Pretreatments such as blocking steps for endogenous activities and antigen retrieval are included. Standard procedures on formalin-fixed, paraffin-embedded tissues as well as method standardization for new antibodies and troubleshooting are emphasized...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28745043/ehrlich-reaction-evoked-multiple-spectral-resonances-and-gold-nanoparticle-hotspots-for-raman-detection-of-plant-hormone
#12
Fangyuan Wang, Xiaoling Gu, Chunchen Zheng, Fang Dong, Liying Zhang, Yueqing Cai, Zhengyi You, Junhui You, Shuhu Du, Zhongping Zhang
Surface-enhanced Raman scattering (SERS) by use of noble metal nanoparticles has become a powerful tool to determine a low-concentration target by unique spectral fingerprints, but it is still limited to the Raman-inactive and nonresonant biomolecules such as amine acids, proteins, and hormones. Here, we report an Ehrlich reaction based derivative strategy in combination with gold nanoparticles (Au NPs) hotspots for the selective detection of indole-like plant hormones by SERS spectroscopy. Ehrlich reaction of p-(dimethylamino)benzaldehyde (PDAB) with the indole ring chemically transformed plant hormone indole-3-butyric acid (IBA) into a Raman-active and resonant derivative with an extended π-conjugated system in the form of a cation, which produced a new absorption band at 626 nm...
August 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28741638/-19-f-cest-imaging-probes-for-metal-ion-detection
#13
Qiaoli Peng, Yaping Yuan, Huaibin Zhang, Shaowei Bo, Yu Li, Shizhen Chen, Zhigang Yang, Xin Zhou, Zhong-Xing Jiang
For detecting metal ions with (19)F chemical exchange saturation transfer magnetic resonance imaging ((19)F CEST MRI), a class of novel fluorinated chelators with diverse fluorine contents and chelation properties were conveniently synthesized on gram scales. Among them, a DTPA-derived chelator with high sensitivity and selectivity was identified as a novel (19)F CEST imaging probe for simultaneously detecting multiple metal ions.
August 2, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28741290/biochemical-characterization-of-lysine-acetylation-of-tyrosyl-trna-synthetase-in-escherichia-coli
#14
Sumana Venkat, Caroline Gregory, Qinglei Gan, Chenguang Fan
Aminoacyl-tRNA synthetases (AARSs) play essential roles in protein synthesis. As a member of the AARS family, the tyrosyl-tRNA synthetase (TyrRS) in Escherichia coli has been shown to be acetylated at multiple lysine residues by proteomic studies. However, these putative acetylation targets have not been biochemically characterized yet. In this study, we applied the genetic code expansion strategy to site-specifically incorporate Nε-acetyl-L-lysine into selected positions of TyrRS for in vitro characterization...
July 24, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28740546/a-paper-based-device-for-performing-loop-mediated-isothermal-amplification-with-real-time-simultaneous-detection-of-multiple-dna-targets
#15
Youngung Seok, Hyou-Arm Joung, Ju-Young Byun, Hyo-Sung Jeon, Su Jeong Shin, Sanghyo Kim, Young-Beom Shin, Hyung Soo Han, Min-Gon Kim
Paper-based diagnostic devices have many advantages as a one of the multiple diagnostic test platforms for point-of-care (POC) testing because they have simplicity, portability, and cost-effectiveness. However, despite high sensitivity and specificity of nucleic acid testing (NAT), the development of NAT based on a paper platform has not progressed as much as the others because various specific conditions for nucleic acid amplification reactions such as pH, buffer components, and temperature, inhibitions from technical differences of paper-based device...
2017: Theranostics
https://www.readbyqxmd.com/read/28736875/assessment-of-unilateral-ureter-obstruction-with-multi-parametric-mri
#16
Feng Wang, Keiko Takahashi, Hua Li, Zhongliang Zu, Ke Li, Junzhong Xu, Raymond C Harris, Takamune Takahashi, John C Gore
PURPOSE: Quantitative multi-parametric MRI (mpMRI) methods may allow the assessment of renal injury and function in a sensitive and objective manner. This study aimed to evaluate an array of MRI methods that exploit endogenous contrasts including relaxation rates, pool size ratio (PSR) derived from quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST), nuclear Overhauser enhancement (NOE), and apparent diffusion coefficient (ADC) for their sensitivity and specificity in detecting abnormal features associated with kidney disease in a murine model of unilateral ureter obstruction (UUO)...
July 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28728787/prenatal-co-exposure-to-manganese-and-depression-and-24-months-neurodevelopment
#17
Teresa Verenice Muñoz-Rocha, Marcela Tamayo Y Ortiz, Martín Romero, Ivan Pantic, Lourdes Schnaas, David Bellinger, Birgit Claus-Henn, Rosalind Wright, Robert O Wright, Mara Téllez-Rojo
BACKGROUND: Normal prenatal neurodevelopment follows stages that are potentially influenced by both chemical and psychosocial environments. Exposure to elevated manganese during this critically vulnerable period has been found to be neurotoxic. Independently, maternal prenatal depression has been associated with subsequent neurodevelopmental decrements in children. The association between child neurodevelopment and prenatal co-exposure to manganese and maternal depression has not been sufficiently studied...
July 17, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28726292/-in-visibility-online-the-benefits-of-online-patient-forums-for-people-with-a-hidden-illness-the-case-of-multiple-chemical-sensitivities-mcs
#18
Tarryn Phillips, Tyson Rees
Sufferers of medically unexplained conditions that are not observable in the clinic can experience multiple layers of invisibility: a lack of biomedical diagnosis; legal skepticism; political disinterest; and a loss of their prior social identity. For those with environmental sensitivities, this is compounded by literal hiddenness due to often being housebound. Drawing on an online survey of people with multiple chemical sensitivity, this article examines how the everyday experience of invisibility is mitigated by engaging with other patients online...
July 20, 2017: Medical Anthropology Quarterly
https://www.readbyqxmd.com/read/28724415/identification-and-characterization-of-the-antiplasmodial-activity-of-hsp90-inhibitors
#19
Claribel Murillo-Solano, Chunmin Dong, Cecilia G Sanchez, Juan C Pizarro
BACKGROUND: The recent reduction in mortality due to malaria is being threatened by the appearance of Plasmodium falciparum parasites that are resistant to artemisinin in Southeast Asia. To limit the impact of resistant parasites and their spread across the world, there is a need to validate anti-malarial drug targets and identify new leads that will serve as foundations for future drug development programmes targeting malaria. Towards that end, the antiplasmodial potential of several Hsp90 inhibitors was characterized...
July 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28723170/highly-efficient-multiple-anchored-fluorescent-probe-for-the-detection-of-aniline-vapor-based-on-synergistic-effect-chemical-reaction-and-pet
#20
Zinuo Jiao, Yu Zhang, Wei Xu, Xiangtao Zhang, Haibo Jiang, Pengcheng Wu, Yanyan Fu, Qingguo He, Huimin Cao, Jiangong Cheng
A multiple-anchored fluorescent probe ((((hexane-1,6-diylbis(2,7-bis(4-formyl)-phenyl)-9H-fluorine-9,9-diyl))-bis(hexane-6,1-diyl))-bis(9H-carbazole-9,3,6-triyl))-tetrakis(benzene-4,1-diyl))-tetraformyl-(8FP-2F) with eight aldehyde groups was designed and synthesized. The molecule has four branches and highly twisted structure. Furthermore, it tends to self-assemble into nanospheres, which is beneficial for gaseous analyte penetration and high fluorescence quantum efficiency. Among gaseous analytes, detection of aniline vapor is extraordinarily important in the control of environmental issues and human diseases...
May 26, 2017: ACS Sensors
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