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Multiple Chemical Sensitivities

B Alex Merrick, Justin S Chang, Dhiral P Phadke, Meredith A Bostrom, Ruchir R Shah, Xinguo Wang, Oksana Gordon, Garron M Wright
The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1), for 90 days prior to liver tumor onset. Among >1,000 differentially expressed transcripts, several novel, unannotated Cufflinks-assembled transcripts, or HAfTs (Hepatic Aflatoxin Transcripts) were found. We hypothesized PCR-cloning and RACE (rapid amplification of cDNA ends) could further HAfT identification. Sanger data was obtained for 6 transcripts by PCR and 16 transcripts by 5'- and 3'-RACE...
2018: PloS One
Christopher P Leonetti, Craig M Butt, Heather M Stapleton
Brominated flame retardants (BFRs) have been shown to disrupt thyroid hormone (TH) homeostasis through multiple mechanisms, including inhibition of enzymes that regulate intracellular levels of THs, such as sulfotransferases (SULTs). The placenta plays a critical role in helping to maintain TH levels during fetal development and expresses SULTs. This is concerning given that disruption of TH regulation within the placenta could potentially harm the developing fetus. In this study, we investigated the effects of two polybrominated diphenyl ethers (PBDEs), two hydroxylated PBDEs, and 2,4,6-tribromophenol (2,4,6-TBP) on TH SULT activity in a choriocarcinoma placenta cell line (BeWo)...
December 28, 2017: Chemosphere
Anne Steinemann
OBJECTIVE: To assess the prevalence of multiple chemical sensitivities (MCS), its co-occurrence with asthma and fragrance sensitivity, and effects from exposure to fragranced consumer products. METHODS: A nationally representative cross-sectional population-based sample of adult Americans (n = 1,137) was surveyed in June 2016. RESULTS: Among the population, 12.8% report medically diagnosed MCS and 25.9% report chemical sensitivity. Of those with MCS, 86...
January 11, 2018: Journal of Occupational and Environmental Medicine
Thomas C Richardson, Shibin Mathew, Joseph E Candiello, Saik K Goh, Prashant N Kumta, Ipsita Banerjee
Human embryonic stem cells (hESC)-derived functional cells hold great promise for regenerative cell therapy. Currently approved strategies for clinical translation requires the isolation of the hESCs-derived cells in materials allowing transfer of reagents but preventing integration with the host. However, hESC fate is known to be sensitive to its local microenvironment, both chemical and physical. Given the complexity of hESC response to environmental parameters, it will be important to evaluate the cell response to multiple combinatorial perturbations...
January 5, 2018: Biotechnology Journal
Melin J Khandekar, Alexander S Banks, Dina Laznik-Bogoslavski, James P White, Jang Hyun Choi, Lawrence Kazak, James C Lo, Paul Cohen, Kwok-Kin Wong, Theodore M Kamenecka, Patrick R Griffin, Bruce M Spiegelman
The peroxisome-proliferator receptor-γ (PPARγ) is expressed in multiple cancer types. Recently, our group has shown that PPARγ is phosphorylated on serine 273 (S273), which selectively modulates the transcriptional program controlled by this protein. PPARγ ligands, including thiazolidinediones (TZDs), block S273 phosphorylation. This activity is chemically separable from the canonical activation of the receptor by agonist ligands and, importantly, these noncanonical agonist ligands do not cause some of the known side effects of TZDs...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
Eileen McNeely, Steven J Staffa, Irina Mordukhovich, Brent Coull
BACKGROUND: Flight attendants at Alaska Airlines reported health symptoms after the introduction of new uniforms in 2011. The airline replaced the uniforms in 2014 without acknowledging harm. To understand possible uniform-related health effects, we analyzed self-reported health symptoms in crew who participated in the Harvard Flight Attendant Health Study between 2007 and 2015, the period before, during, and after the introduction of new uniforms. METHODS: We calculated a standardized prevalence of respiratory, dermatological and allergic symptoms at baseline, as well as during and after uniform changes in 684 flight attendants with a varying number of surveys completed across each time point...
January 3, 2018: BMC Public Health
Sivakumar Prasanth Kumar, Prakash C Jha
Numerous caspase-3 drug discovery projects were found to have relied on single receptor as the template to recognize most promising small molecule candidates using docking approach. Alternatively, some researchers were contingent upon ligand-based alignment to build up an empirical relationship between ligand functional groups and caspase-3 inhibitory activity quantitatively. To connect both caspase-3 receptor details and its inhibitors chemical functionalities, we developed multi-pharmacophore model based on flexible (conformations unrestricted or flexible during pharmacophore mapping), dock (conformations obtained using FlexX docking method) and crystal (extracted from multiple caspase-3-ligand complexes from PDB repository) conformations of query ligands...
January 1, 2018: Combinatorial Chemistry & High Throughput Screening
Devaraj Manoj, K Theyagarajan, Duraisamy Saravanakumar, Sellappan Senthilkumar, Kathavarayan Thenmozhi
An aldehyde functionalized ionic liquid, (3-(3-formyl-4-hydroxybenzyl)-3-methylimidazolium hexafluorophosphate) (CHO-IL) has been employed herein as a multiple host platform for the covalent immobilization of mediator as well as enzyme. The CHO-IL was immobilized on electrochemically reduced graphene oxide (ERGO) through the π-π stacking of hydroxybenzyl and imidazolium groups with ERGO and subjected to further covalent attachment of Azure A (Azu-A) mediator or glucose oxidase (GOx) enzyme. Electroactive, water soluble organic dye Azu-A was effectively immobilized to the host IL through simple Schiff base reaction...
December 21, 2017: Biosensors & Bioelectronics
Alex Henning, Nandhini Swaminathan, Yonathan Vaknin, Titel Jurca, Klimentiy Anatoliy Shimanovich, Gil Shalev, Yossi Rosenwaks
The ability to control surface-analyte interaction allows tailoring chemical sensor sensitivity to specific target molecules. Adjusting the bias of the shallow p-n junctions in the electrostatically-formed nanowire (EFN) chemical sensor, a multiple gate transistor with an exposed top dielectric layer, allows tuning of the fringing electric field strength (from 0.5×107 to 2.5×107 V/m) above the EFN surface. Herein, we report that the magnitude and distribution of this fringing electric field correlate with the intrinsic sensor response to volatile organic compounds...
December 26, 2017: ACS Sensors
Izumi Yonekawa, Katsuya Mutoh, Yoichi Kobayashi, Jiro Abe
Light-selective multiple photochromic systems are important for advanced photoswitches of chemical reactions and biological activities. While UV light has been frequently utilized to induce photochromic reactions, visible light is energetically acceptable to avoid undesired reactions. However, many of the reported multi-photochromic systems still rely on UV light to induce at least a part of photochromic reactions. Here, we designed a bi-photochromic molecule showing intensity-dependent multiple coloration with a visible light source by incorporating two T-type photochromic units; a colored positive and a colorless negative photochromophores in a molecule...
December 23, 2017: Journal of the American Chemical Society
Karan Kumar Gupta, R M Kadam, N S Dhoble, S P Lochab, S J Dhoble
The present paper reports on the γ-ray and C6+ ion beam induced effect on the structural and luminescence properties of Eu doped LiNaSO4 phosphors synthesized via wet the chemical method. The material was irradiated by 60Co and 137Cs γ-rays and 75 MeV C6+ ions in a fluence range varying from 2 × 1010 to 1 × 1012 ion per cm2. The ion induced modified properties were investigated using X-ray diffraction (XRD), micro-Raman spectroscopy, photoluminescence (PL), thermoluminescence (TL) and electron paramagnetic resonance (EPR) studies...
December 20, 2017: Physical Chemistry Chemical Physics: PCCP
Yong Heo, Sang-Hoon Kim, Seok-Ki Lee, Hyoung-Ah Kim
Multiple chemical sensitivity (MCS), an acquired disorder with multiple recurrent symptoms, has been studied for its association with diverse environmental factors. The present study investigated the factors associated with the self-reported prevalence of MCS in public facility workers and the general population in Korea. The Quick Environmental Exposure Sensitivity Inventory (QEESI) questionnaire was obtained from public facility workers (N=530) and the general population (N=500) to determine the prevalence of MCS and the degree of its risk...
2017: Journal of UOEH
Jia-Kai Zeng, Yuan-Yuan Li, Tian-Ming Wang, Jie Zhong, Jia-Sheng Wu, Ping Liu, Hua Zhang, Yue-Ming Ma
A rapid, sensitive, and accurate UPLC-MS/MS method was developed for the simultaneous quantification of components of Huangqi decoction (HQD), such as calycosin-7-O-β-D-glucoside, calycosin-glucuronide, liquiritin, formononetin-glucuronide, isoliquiritin, liquiritigenin, ononin, calycosin, isoliquiritigenin, formononetin, glycyrrhizic acid, astragaloside IV, cycloastragenol, and glycyrrhetinic acid, in rat plasma. After plasma samples were extracted by protein precipitation, chromatographic separation was performed with a C18 column, using a gradient of methanol and 0...
December 15, 2017: Biomedical Chromatography: BMC
Jake Pawlowski, Ian Carrick, Igor A Kaltashov
Profiling of complex proteins by means of mass spectrometry (MS) frequently requires that certain chemical modifications of their covalent structure (e.g., reduction of disulfide bonds) be carried out prior to the MS or MS/MS analysis. Traditionally, these chemical reactions take place in the off-line mode to allow the excess reagents (the majority of which interfere with the MS measurements and degrade the analytical signal) to be removed from the protein solution prior to MS measurements. In addition to a significant increase in the analysis time, chemical reactions may result in a partial or full loss of the protein if the modifications adversely affect its stability, e...
December 14, 2017: Analytical Chemistry
Sean Yu, Pranav Joshi, Yi Ju Park, Kyeong-Nam Yu, Moo-Yeal Lee
Layer-by-layer cell printing is useful in mimicking layered tissue structures inside the human body and has great potential for being a promising tool in the field of tissue engineering, regenerative medicine, and drug discovery. However, imaging human cells cultured in multiple hydrogel layers in 3D-printed tissue constructs is challenging as the cells are not in a single focal plane. Although confocal microscopy could be a potential solution for this issue, it compromises the throughput which is a key factor in rapidly screening drug efficacy and toxicity in pharmaceutical industries...
December 14, 2017: Biotechnology Progress
Kathryn Lee, Markus Lankers, Oliver Valet
Raw materials need to be of a certain quality with respect to physical and chemical composition. They also need to have no contaminants, including particles, because these could indicate raw material impurities or contaminate the product. Particle identification allows determination of process conditions that caused them and whether the quality of the final product is acceptable. Particles may appear to the eye to be very different things than they actually are. They may be coated with the raw material and may consist of several components; therefore, chemical and elemental analyses are required for accuracy in proper identification and definitive information about their source...
January 1, 2017: Applied Spectroscopy
Ludi Wang, Wei Yang, Siyang Wu, Shuyao Wang, Chen Kang, Xiaoli Ma, Yingfei Li, Chuan Li
Isochamaejasmin, neochamaejasmin A, and daphnoretin derived from Stellera chamaejasme L. are important because of their reported anti-cancer properties. In this study, a sensitive UPLC-MS/MS method for the determination of isochamaejasmin, neochamaejasmin A, and daphnoretin in rat plasma was developed. The analyte and IS were separated on an Acquity UPLC HSS T3 column (100 × 2.1 mm, 1.8μm) using gradient elution with the mobile phase of aqueous solution (methanol/water, 1:99, v/v, containing 1 mM formic acid) and organic solution (methanol/water, 99:1, v/v, containing 1 mM formic acid) at a flow rate of 0...
December 12, 2017: Biomedical Chromatography: BMC
A Kotnala, S Senthilkumari, N Halder, A Kumar, T Velpandian
PURPOSE: To develop a microwave assisted method for the rapid synthesis of A2E and also to develop a method to quantify N-retinylidene-N-retinylethanolamine(A2E), all-trans retinal dimer (ATRD), A2-glycerophospho ethanolamine (A2GPE), dihydropyridine phosphatidyl ethanolamine (A2DHPE) and monofuran A2E (MFA2E) in age matched retina. METHODS: The development of microwave assisted synthesis of A2E, its purification and characterization for its utility in quantification in human retina...
November 26, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Gabriel Beikircher, Walter Pulverer, Manuela Hofner, Christa Noehammer, Andreas Weinhaeusel
DNA methylation is a chemically stable key-player in epigenetics. In the vertebrate genome the 5-methyl cytosine (5mC) has been found almost exclusively in the CpG dinucleotide context. CpG dinucleotides are enriched in CpG islands very frequently located within or close to gene promoters. Analyses of DNA methylation changes in human diagnostics have been conducted classically using methylation-sensitive restriction enzymes (MSRE). Since the discovery of bisulfite conversion-based sequencing and PCR assays, MSRE-based PCR assays have been less frequently used, although especially in the field of cancer epigenetics MSRE-based genome-wide discovery and targeted screening applications have been and are still performed successfully...
2018: Methods in Molecular Biology
Wei-Ming Cheng, Yu-Hua Fan, Alex T L Lin
BACKGROUND: The aim of the study was to identify the impact of non-bladder co-morbid conditions on the urodynamic characteristics of patients with bladder pain syndrome/interstitial cystitis. METHODS: Patients with bladder pain syndrome/interstitial cystitis completed the screening questionnaires for chronic fatigue syndrome, irritable bowel syndrome, fibromyalgia, temporo-mandibular disorders, multiple chemical sensitivities, tension/migraine headache, and localized myofascial pain disorder...
December 6, 2017: Journal of the Chinese Medical Association: JCMA
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