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https://www.readbyqxmd.com/read/27688156/mesenchymal-stem-cells-in-the-treatment-of-chronic-lung-disease
#1
Sophie Wecht, Mauricio Rojas
Mesenchymal stem cells (MSCs) are a populace of non-haematopoietic multipotent stromal cells, which have the ability to differentiate into tissue derived from a single germ layer. MSCs have been isolated from various sites, including adipose tissue, skeletal muscle, synovium, spleen, thymus, lung and amniotic fluid, but are most often isolated from bone marrow. MSCs have several valuable functions that make them a promising therapeutic option in the field of regenerative medicine, including the secretion of anti-inflammatory cytokines and growth factors, the migration of cells to the site of injury when administered and the ability to 'rescue' cells through the transfer of functional mitochondria...
November 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27687213/facilitators-and-barriers-to-the-use-of-standing-orders-for-vaccination-in-obstetrics-and-gynecology-settings
#2
Juliana G Barnard, Amanda F Dempsey, Sarah E Brewer, Jennifer Pyrzanowski, Sara E Mazzoni, Sean T O'Leary
BACKGROUND: Many young and middle-aged women receive their primary health care from their obstetrician-gynecologists. A recent change to vaccination recommendations during pregnancy has forced the integration of new clinical processes at obstetrician-gynecology practices. Evidence-based best practices for vaccination delivery include the establishment of vaccination standing orders. OBJECTIVES: As part of an intervention to increase adoption of evidence-based vaccination strategies for women in safety-net and private obstetrician-gynecology settings, we conducted a qualitative study to identify the facilitators and barriers experienced by obstetrician-gynecology sites when establishing vaccination standing orders...
September 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27565747/perspectives-on-global-health-amongst-obstetrician-gynecologists-a-national-survey
#3
Sarah Rae Easter, Greta B Raglan, Sarah E Little, Jay Schulkin, Julian N Robinson
OBJECTIVE: To characterize contemporary attitudes toward global health amongst board-certified obstetricians-gynecologists (Ob-Gyns) in the US. METHODS: A questionnaire was mailed to members of the American College of Obstetricians and Gynecologists. Respondents were stratified by interest and experience in global health and group differences were reported. RESULTS: A total of 202 of 400 (50.5%) surveys were completed; and 67.3% (n = 136) of respondents expressed an interest in global health while 25...
August 25, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27513777/a-new-method-of-directing-endoscope-pathway-in-single-nostril-transpheoidal-approach-for-safety-by-using-volume-rendering-with-thin-section-computed-tomographic-image
#4
Xiangliang Liu, Xiao Chen, Yiheng Wang, Wei Ji, Wenchao Zhao, Shuai Yang, Li Li, Zhen Wang, Xinyu Xu, Mingcheng Yuan, Wei Li, Youqiong Li
OBJECTIVE: This study aims to locate important structures surrounding the sella node and measure the distances and angles between signalized points by using both three-dimensional reconstruction technique and volume-rendering. These distances and angles can provide more accurate reference for surgeries in pituitary adenomas. METHODS: Ninty volunteers' skulls were scanned and thin-section computed tomographic images were displayed. The highest point of saddle node on double sides were marked as point A (right) and A1 (left), the highest point of posterior Clinton process on double side as B (right) and B1 (left)...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27381525/syndecan-4-enhances-pdgf-bb-activity-in-diabetic-wound-healing
#5
Subhamoy Das, Marjan Majid, Aaron B Baker
UNLABELLED: Non-healing ulcers are a common consequence of long-term diabetes and severe peripheral vascular disease. These non-healing wounds are a major source of morbidity in patients with diabetes and place a heavy financial burden on the healthcare system. Growth factor therapies are an attractive strategy for enhancing wound closure in non-healing wounds but have only achieved mixed results in clinical trials. Platelet derived growth factor-BB (PDGF-BB) is the only currently approved growth factor therapy for non-healing wounds...
September 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27275804/ensuring-access-to-safe-legal-abortion-in-an-increasingly-complex-regulatory-environment
#6
Maureen Paul, Mary E Norton
Restrictions on access to abortion in the United States have reached proportions unprecedented since the nationwide legalization of abortion in 1973. Although some restrictions aim to discourage women from having abortions, many others impede access by affecting the timeliness, affordability, or availability of services. Evidence indicates that these restrictions do not increase abortion safety; rather, they create logistic barriers for women seeking abortion, and they have the greatest effect on women with the fewest resources...
July 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27107397/reliability-of-office-based-narrow-band-imaging-guided-flexible-laryngoscopic-tissue-samplings
#7
Catherine Chang, Wan-Ni Lin, Li-Jen Hsin, Li-Ang Lee, Chien-Yu Lin, Hsueh-Yu Li, Chun-Ta Liao, Tuan-Jen Fang
OBJECTIVES/HYPOTHESIS: Direct suspension laryngoscopic biopsy performed under general anesthesia is the conventional management for obtaining pathological diagnosis for neoplasms of the larynx, oropharynx, and hypopharynx. Since the development of distal chip laryngoscopy and digital imaging systems, transnasal flexible laryngoscopy tissue sampling has gained popularity as an office-based procedure. Additional assessment with narrow-band imaging (NBI) can help to increase the diagnostic yield...
April 23, 2016: Laryngoscope
https://www.readbyqxmd.com/read/26971682/cardiopulmonary-and-histological-characterization-of-an-acute-rat-lung-injury-model-demonstrating-safety-of-mesenchymal-stromal-cell-infusion
#8
Rudolf K Braun, Jill M Koch, Timothy A Hacker, David Pegelow, Jaehyup Kim, Amish N Raval, Eric G Schmuck, Denise J Schwahn, Derek J Hei, John M Centanni, Marlowe Eldridge, Peiman Hematti
BACKGROUND AIMS: In the field of cellular therapy, potential cell entrapment in the lungs following intravenous administration in a compromised or injured pulmonary system is an important concern that requires further investigation. We developed a rat model of inflammatory and fibrotic lung disease to mimic the human clinical condition of obliterative bronchiolitis (OB) and evaluate the safety of intravenous infusion of mesenchymal stromal cells (MSCs). This model was used to obtain appropriate safety information and functional characterization to support the translation of an ex vivo-generated cellular product into human clinical trials...
April 2016: Cytotherapy
https://www.readbyqxmd.com/read/26949324/survey-of-obstetrics-and-gynecology-residents-regarding-pneumococcal-vaccination-in-pregnancy-education-knowledge-and-barriers-to-vaccination
#9
Emily E Fay, Kara K Hoppe, Jay Schulkin, Linda O Eckert
OBJECTIVE: The 23-valent pneumococcal vaccine is recommended for adults over 65 years of age and younger adults with certain medical conditions. The Centers for Disease Control and Prevention (CDC) state insufficient evidence to recommend routine pneumococcal vaccination during pregnancy, but the vaccine is indicated for pregnant women with certain medical conditions. We designed this project to gauge obstetrics and gynecology (OB/GYN) resident knowledge of maternal pneumococcal vaccination...
2016: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26945939/robotic-partial-nephrectomy-during-pregnancy-case-report-and-special-considerations
#10
Daniel Ramirez, Matthew J Maurice, Catherine Seager, Georges-Pascal Haber
OBJECTIVE: To report a case of robotic partial nephrectomy (RPN) during pregnancy and review the existing literature on the topic. METHODS: A 35-year-old asymptomatic pregnant woman at 20 weeks gestation was found to have a large mass in the right kidney during routine anatomic ultrasound for fetal assessment. Magnetic resonance imaging demonstrated a 7.5 cm right upper-pole solid-enhancing renal mass, concerning for malignancy, without evidence of local extension or metastases...
June 2016: Urology
https://www.readbyqxmd.com/read/26942392/committee-opinion-no-657-the-obstetric-and-gynecologic-hospitalist
#11
(no author information available yet)
The term "hospitalist" refers to physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities may include patient care, teaching, research, and inpatient leadership. The American College of Obstetricians and Gynecologists supports the continued development and study of the obstetric and gynecologic (ob-gyn) hospitalist model as one potential approach to improve patient safety and professional satisfaction across delivery settings. Effective patient handoffs, updates on progress, and clear follow-up instructions between ob-gyn hospitalists and patients, nurses, and other health care providers are vital to maintaining patient safety...
February 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26942385/committee-opinion-no-657-summary-the-obstetric-and-gynecologic-hospitalist
#12
REVIEW
(no author information available yet)
The term "hospitalist" refers to physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities may include patient care, teaching, research, and inpatient leadership. The American College of Obstetricians and Gynecologists supports the continued development and study of the obstetric and gynecologic (ob-gyn) hospitalist model as one potential approach to improve patient safety and professional satisfaction across delivery settings. Effective patient handoffs, updates on progress, and clear follow-up instructions between ob-gyn hospitalists and patients, nurses, and other health care providers are vital to maintaining patient safety...
February 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26928154/integrase-inhibitors-in-late-pregnancy-and-rapid-hiv-viral-load-reduction
#13
Lisa Rahangdale, Jordan Cates, JoNell Potter, Martina L Badell, Dominika Seidman, Emilly S Miller, Jenell S Coleman, Gweneth B Lazenby, Judy Levison, William R Short, Sigal Yawetz, Andrea Ciaranello, Elizabeth Livingston, Lunthita Duthely, Bassam H Rimawi, Jean R Anderson, Elizabeth M Stringer
BACKGROUND: Minimizing time to HIV viral suppression is critical in pregnancy. Integrase strand transfer inhibitors (INSTIs), like raltegravir, are known to rapidly suppress plasma HIV RNA in nonpregnant adults. There are limited data in pregnant women. OBJECTIVE: We describe time to clinically relevant reduction in HIV RNA in pregnant women using INSTI-containing and non-INSTI-containing antiretroviral therapy (ART) options. STUDY DESIGN: We conducted a retrospective cohort study of pregnant HIV-infected women in the United States from 2009 through 2015...
March 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26818406/interchangeability-safety-and-efficacy-of-modified-release-drug-formulations-in-the-usa-the-case-of-opioid-and-other-nervous-system-drugs
#14
Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, Richard Hansen
BACKGROUND AND OBJECTIVES: Modified-release drugs may provide clinical advantages compared to immediate-release forms and improve convenience to the patient and health outcomes. Concerns have been raised regarding interchangeability, efficacy, and safety of modified-release formulations. This study analyses all US Food and Drug Administration (FDA)-approved modified-release formulations and market trends, and illustrates how bioequivalence and safety of generic modified-release products compare to their respective brand name drugs and other generic drugs with different formulation design characteristics...
April 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/26597558/organizational-behavior-a-brief-overview-and-safety-orientation
#15
REVIEW
Mary J Waller
Organizational Behavior (OB) is a discipline of social science that seeks explanations for human behavior in organizations. OB draws on core disciplines such as psychology, sociology, anthropology, economics, communication, and law to create and investigate multilevel explanations of why people engage in particular behaviors, and which behaviors under which circumstances lead to better outcomes in organizations. Created using an applied or pragmatic lens and tested with a wide range of both quantitative and qualitative methodologies, most OB theories and research have direct implications for managers and for other organizational participants...
December 2015: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/26577995/characterization-and-evaluation-of-a-folic-acid-receptor-targeted-cyclodextrin-complex-as-an-anticancer-drug-delivery-system
#16
Jiaojiao Xu, Beihua Xu, Dan Shou, Fuhua Qin, Yong Xu, Ying Hu
To improve the water solubility and tumor targeting ability of docetaxel (DTX), and thus enhance the drug's antitumor efficacy and safety, a novel folate receptor (FR)-targeted cyclodextrin drug delivery vehicle (FA-CD) was successfully synthesized. The synthesis of the designed cyclodextrin was confirmed by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR), and differential scanning calorimetry (DSC). The in vitro cytotoxicity was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the results showed that no significant differences (p>0...
February 15, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26562703/evaluating-quality-of-care-for-sexually-transmitted-infections-in-different-clinical-settings
#17
Shwetha Sequeira, Jake R Morgan, Maura Fagan, Katherine K Hsu, Mari-Lynn Drainoni
BACKGROUND: We examined quality of care across different clinical settings within a large safety-net hospital in Massachusetts for patients presenting with penile discharge/dysuria or vaginal discharge. METHODS: Using a modified Delphi approach, a list of sex-specific sexually transmitted infection (STI) quality measures, covering 7 domains of clinical care (history, examination, laboratory testing, assessment, treatment, additional screening, counseling), was selected as standard of care by a panel of 5 STI experts representing emergency department (ED), obstetrics/gynecology (Ob/Gyn), family medicine (FM), primary care (PC), and infectious disease...
December 2015: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/26366799/first-assessment-of-short-term-efficacy-of-er-yag-laser-treatment-on-stress-urinary-incontinence-in-women-prospective-cohort-study
#18
N Fistonić, I Fistonić, A Lukanovič, Š Findri Guštek, I Sorta Bilajac Turina, D Franić
OBJECTIVES: This is the first assessment of efficacy and safety of the Er:YAG laser in the treatment of stress urinary incontinence. The aim of this study was to assess the short-term outcome of a non-invasive laser treatment for mild-to-severe stages of this condition and to check its applicability in different body mass index and age groups. METHODS: A prospective cohort, single-center study at the Ob/Gyn Clinic, Zagreb, Croatia recruited a consecutive sample of 73 female patients suffering from stress urinary incontinence...
2015: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/26333641/organizing-an-effective-obstetric-gynecologic-hospitalist-program
#19
REVIEW
Christopher Swain, Mark Simon, Brian Monks
The thoughtful development and implementation of a comprehensive obstetric/gynecologic (OB/GYN) hospitalist program can result in a cost-effective practice model that provides increased value through a wide variety of services. The continuous on-site availability of an OB/GYN specialist affords many benefits to patients, hospitals, and practicing physicians. A well-implemented and effective OB/GYN hospitalist program will be associated with many different service line improvements for hospitals. Such programs increase patient safety, promote risk reduction, and improve clinical outcomes, while enriching the quality of life of obstetricians and gynecologists...
September 2015: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/26333640/obstetrics-hospitalists-risk-management-implications
#20
REVIEW
Larry Veltman
The concept of having an in-house obstetrician (serving as an obstetrics [OB] hospitalist) available 24 hours a day, 7 days a week provides a safety net for OB events that many need immediate intervention for a successful outcome. A key precept of risk management, that of loss prevention, fits perfectly with the addition of an OB hospitalist role in the perinatal department. Inherent in the role of OB hospitalists are the patient safety and risk management principles of improved communication, enhanced readiness, and immediate availability...
September 2015: Obstetrics and Gynecology Clinics of North America
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