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https://www.readbyqxmd.com/read/29062587/one-week-glucose-control-via-zero-order-release-kinetics-from-an-injectable-depot-of-glucagon-like-peptide-1-fused-to-a-thermosensitive-biopolymer
#1
Kelli M Luginbuhl, Jeffrey L Schaal, Bret Umstead, Eric M Mastria, Xinghai Li, Samagya Banskota, Susan Arnold, Mark Feinglos, David D'Alessio, Ashutosh Chilkoti
Stimulation of the glucagon-like peptide-1 (GLP1) receptor is a useful treatment strategy for type 2 diabetes because of pleiotropic effects, including the regulation of islet hormones and the induction of satiety. However, the native ligand for the GLP1 receptor has a short half-live owing to enzymatic inactivation and rapid clearance. Here, we show that a subcutaneous depot formed after a single injection of GLP1 recombinantly fused to a thermosensitive elastin-like polypeptide results in zero-order release kinetics and circulation times of up to 10 days in mice and 17 days in monkeys...
2017: Nature biomedical engineering
https://www.readbyqxmd.com/read/29057457/differential-effects-of-selective-agonists-of-neuromedin-u1-and-2-receptors-in-obese-and-diabetic-mice
#2
Hiroaki Nagai, Tomoko Kaisho, Kotaro Yokoyama, Tomoko Asakawa, Hisashi Fujita, Kouta Matsumiya, Jiro Noguchi, Kazue Tsuchimori, Naoki Nishizawa, Yoko Kanematsu-Yamaki, Katsuko Dote, Hiroshi Inooka, Jun-Ichi Sakamoto, Tetsuya Ohtaki, Taiji Asami, Shiro Takekawa
BACKGROUND AND PURPOSE: Neuromedin U (NMU) may be a novel target for obesity treatment owing to its anorectic and energy expenditure enhancing effects. Although two receptors, NMU1 and NMU2, are both responsible for the NMU-mediated anti-obesity effects, the receptor agonist with the most appropriate profiles for treating obesity and diabetes in terms of efficacy and safety is as yet unknown. Thus, we developed and evaluated novel NMU1/2 receptor-selective agonists. EXPERIMENTAL APPROACH: Efficacy and safety were assessed in mice with diet-induced obesity (DIO) and those with leptin-deficient diabetes (ob/ob) through repeated peripheral administration of selective agonists to NMU1 (NMU-6102) and NMU2 (NMU-2084), along with NMU1/2 non-selective agonists (NMU-0002 and NMU-6014)...
October 22, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28922318/vaccination-during-pregnancy-first-line-of-defense-for-expecting-mothers-and-vulnerable-young-infants
#3
Casidhe-Nicole Bethancourt, Tiffany L Wang, Joseph A Bocchini
PURPOSE OF REVIEW: Maternal vaccination is a well-tolerated and effective way to protect mothers, their developing fetuses, and their young infants from infectious diseases. Although influenza vaccine and diphtheria, tetanus, and acellular pertussis (Tdap) vaccine are recommended for all pregnant women, uptake rates in the United States remain low. This review will focus on the rationale, scientific evidence, and perceptions of vaccination during pregnancy. RECENT FINDINGS: Recent studies show that administration of influenza and Tdap vaccines during pregnancy is well tolerated and provides protection to the pregnant woman, her fetus, and young infant...
December 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28826807/building-a-collaboration-between-a-children-s-hospital-and-an-early-childhood-education-and-social-services-center
#4
Donna O'Malley, Briana A Woods-Jaeger, M Denise Dowd
To address toxic stress among children growing up in poverty, an innovative collaboration was developed between a community center, Operation Breakthrough (OB), and a tertiary care children's hospital, Children's Mercy Hospital (CMH). OB started as a day care center but has expanded and developed ways to provide shelter, safety, food, employment, education and health care. CMH is a traditional academic children's hospital that, in recent years, has been looking for ways to better address the social determinants of health...
August 17, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28770341/prenatal-depression-screening-and-antidepressant-prescription-obstetrician-gynecologists-practices-opinions-and-interpretation-of-evidence
#5
Laura H Taouk, Kristen A Matteson, Lauren M Stark, Jay Schulkin
Obstetrician-gynecologists (ob-gyns) are well-positioned to detect symptoms of perinatal depression; however, little is known about how ob-gyns respond. The purpose of this study was to evaluate ob-gyns' beliefs and practices related to prenatal depression screening and antidepressant prescription during pregnancy. A larger survey on prenatal medication was developed at the American College of Obstetricians and Gynecologists (ACOG) and distributed to a sample of 1000 Fellows. The overall response rate was 37...
August 2, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28688814/proceedings-beyond-ultrasound-first-forum-on-improving-the-quality-of-ultrasound-imaging-in-obstetrics-and-gynecology
#6
Beryl R Benacerraf, Katherine K Minton, Carol B Benson, Bryann S Bromley, Brian D Coley, Peter M Doubilet, Wesley Lee, Samuel H Maslak, John S Pellerito, James J Perez, Eric Savitsky, Norman A Scarborough, Joseph Wax, Alfred Z Abuhamad
The Beyond Ultrasound First Forum was conceived to increase awareness that the quality of obstetric and gynecologic ultrasound can be improved, and is inconsistent throughout the country, likely due to multiple factors, including the lack of a standardized curriculum and competency assessment in ultrasound teaching. The forum brought together representatives from many professional associations; the imaging community including radiology, obstetrics and gynecology, and emergency medicine among others; in addition to government agencies, insurers, industry, and others with common interest in obstetric and gynecologic ultrasound...
July 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28594650/impact-of-an-obstetrical-hospitalist-program-on-the-safety-events-in-a-mid-sized-obstetrical-unit
#7
Julie Z Decesare, Suzanne Y Bush, Ashley N Morton
OBJECTIVE: Because internal medicine hospitalist programs were developed to address issues in medicine such as a need to improve quality, improve efficiency, and decrease healthcare cost, obstetrical (OB) hospitalist models were developed to address needs specific to the obstetrics and gynecology field. Our objective was to compare outcomes measured by occurrence of safety events before and after implementation of an OB hospitalist program in a mid-sized OB unit. METHODS: From July 2012 to September 2014, 11 safety events occurred on the labor and delivery floor...
June 8, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28391383/percutaneous-radiofrequency-ablation-for-spinal-osteoid-osteoma-and-osteoblastoma
#8
Ben Wang, Song Bo Han, Liang Jiang, Hui Shu Yuan, Chen Liu, Bin Zhu, Zhong Jun Liu, Xiao Guang Liu
PURPOSES: We sought to verify the efficacy and safety of RFA in spinal OO and osteoblastomas (OB) (Enneking Stage 2, S2). METHODS: We retrospectively reviewed patients treated in our hospital. Surgical resection was indicated for Enneking Stage 3 OB. RFA indications for spinal OO and OB (S2) were no neurological deficits, complete bone cortex around the lesion on computed tomography (CT), and cerebrospinal fluid between a lesion and the spinal cord/nerve root on magnetic resonance imaging...
July 2017: European Spine Journal
https://www.readbyqxmd.com/read/28346353/intake-and-dietary-food-sources-of-fibre-in-spain-differences-with-regard-to-the-prevalence-of-excess-body-weight-and-abdominal-obesity-in-adults-of-the-anibes-study
#9
Liliana G González-Rodríguez, José Miguel Perea Sánchez, Javier Aranceta-Bartrina, Ángel Gil, Marcela González-Gross, Lluis Serra-Majem, Gregorio Varela-Moreiras, Rosa M Ortega
The aim was to study the intake and food sources of fibre in a representative sample of Spanish adults and to analyse its association with excess body weight and abdominal obesity. A sample of 1655 adults (18-64 years) from the ANIBES ("Anthropometric data, macronutrients and micronutrients intake, practice of physical activity, socioeconomic data and lifestyles") cross-sectional study was analysed. Fibre intake and dietary food sources were determined by using a three-day dietary record. Misreporters were identified using the protocol of the European Food Safety Authority...
March 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28261407/factors-influencing-residency-program-selection-by-medical-students-pursuing-obstetrics-and-gynecology
#10
Meredith J Alston, Torri D Metz, Russell Fothergill, Amy Meg Autry, Sarah A Wagner, Amanda A Allshouse, Alyssa Stephenson-Famy
BACKGROUND : Little is known about the factors that influence medical student selection of obstetrics and gynecology (ob-gyn) residency programs. OBJECTIVE : We assessed the factors influencing residency program selection by fourth-year medical students pursuing ob-gyn training. METHODS : A voluntary, anonymous, 19-question survey of residency selection factors was distributed to all fourth-year medical students interviewing at 1 of 5 academic ob-gyn departments for a residency position during the 2013-2014 interview season...
February 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28235465/ovarian-reserve-testing-a-user-s-guide
#11
REVIEW
Reshef Tal, David B Seifer
Ovarian reserve is a complex clinical phenomenon influenced by age, genetics, and environmental variables. Although it is challenging to predict the rate of an individual's ovarian reserve decline, clinicians are often asked for advice about fertility potential and/or recommendations regarding the pursuit of fertility treatment options. The purpose of this review is to summarize the state-of-the-art of ovarian reserve testing, providing a guide for the obstetrician/gynecologist generalist and reproductive endocrinologist...
August 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27986230/barriers-to-global-health-training-in-obstetrics-and-gynecology
#12
Rachel Pope, Maria Shaker, Prakash Ganesh, Margaret Larkins-Pettigrew, Stephanie Deter Pickett
BACKGROUND: The Lancet Commission on Global Surgery includes obstetrics and gynecology as an area needing international strengthening in low- and middle-income countries. Despite interest, a majority of participants in US residency programs graduate with little exposure to global health or preparation to work abroad. OBJECTIVE: The aim of this study was to determine the level of interest of obstetrics and gynecology (Ob/Gyn) residents in gaining global health training and to identify perceived barriers to receiving training...
July 2016: Annals of Global Health
https://www.readbyqxmd.com/read/27688156/mesenchymal-stem-cells-in-the-treatment-of-chronic-lung-disease
#13
REVIEW
Sophie Wecht, Mauricio Rojas
Mesenchymal stem cells (MSCs) are a populace of non-haematopoietic multipotent stromal cells, which have the ability to differentiate into tissue derived from a single germ layer. MSCs have been isolated from various sites, including adipose tissue, skeletal muscle, synovium, spleen, thymus, lung and amniotic fluid, but are most often isolated from bone marrow. MSCs have several valuable functions that make them a promising therapeutic option in the field of regenerative medicine, including the secretion of anti-inflammatory cytokines and growth factors, the migration of cells to the site of injury when administered and the ability to 'rescue' cells through the transfer of functional mitochondria...
November 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27687213/facilitators-and-barriers-to-the-use-of-standing-orders-for-vaccination-in-obstetrics-and-gynecology-settings
#14
Juliana G Barnard, Amanda F Dempsey, Sarah E Brewer, Jennifer Pyrzanowski, Sara E Mazzoni, Sean T O'Leary
BACKGROUND: Many young and middle-aged women receive their primary health care from their obstetrician-gynecologists. A recent change to vaccination recommendations during pregnancy has forced the integration of new clinical processes at obstetrician-gynecology practices. Evidence-based best practices for vaccination delivery include the establishment of vaccination standing orders. OBJECTIVES: As part of an intervention to increase adoption of evidence-based vaccination strategies for women in safety-net and private obstetrician-gynecology settings, we conducted a qualitative study to identify the facilitators and barriers experienced by obstetrician-gynecology sites when establishing vaccination standing orders...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27565747/perspectives-on-global-health-amongst-obstetrician-gynecologists-a-national-survey
#15
Sarah Rae Easter, Greta B Raglan, Sarah E Little, Jay Schulkin, Julian N Robinson
OBJECTIVE: To characterize contemporary attitudes toward global health amongst board-certified obstetricians-gynecologists (Ob-Gyns) in the US. METHODS: A questionnaire was mailed to members of the American College of Obstetricians and Gynecologists. Respondents were stratified by interest and experience in global health and group differences were reported. RESULTS: A total of 202 of 400 (50.5%) surveys were completed; and 67.3% (n = 136) of respondents expressed an interest in global health while 25...
August 25, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27513777/a-new-method-of-directing-endoscope-pathway-in-single-nostril-transpheoidal-approach-for-safety-by-using-volume-rendering-with-thin-section-computed-tomographic-image
#16
Xiangliang Liu, Xiao Chen, Yiheng Wang, Wei Ji, Wenchao Zhao, Shuai Yang, Li Li, Zhen Wang, Xinyu Xu, Mingcheng Yuan, Wei Li, Youqiong Li
OBJECTIVE: This study aims to locate important structures surrounding the sella node and measure the distances and angles between signalized points by using both three-dimensional reconstruction technique and volume-rendering. These distances and angles can provide more accurate reference for surgeries in pituitary adenomas. METHODS: Ninty volunteers' skulls were scanned and thin-section computed tomographic images were displayed. The highest point of saddle node on double sides were marked as point A (right) and A1 (left), the highest point of posterior Clinton process on double side as B (right) and B1 (left)...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27381525/syndecan-4-enhances-pdgf-bb-activity-in-diabetic-wound-healing
#17
Subhamoy Das, Marjan Majid, Aaron B Baker
UNLABELLED: Non-healing ulcers are a common consequence of long-term diabetes and severe peripheral vascular disease. These non-healing wounds are a major source of morbidity in patients with diabetes and place a heavy financial burden on the healthcare system. Growth factor therapies are an attractive strategy for enhancing wound closure in non-healing wounds but have only achieved mixed results in clinical trials. Platelet derived growth factor-BB (PDGF-BB) is the only currently approved growth factor therapy for non-healing wounds...
September 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27275804/ensuring-access-to-safe-legal-abortion-in-an-increasingly-complex-regulatory-environment
#18
Maureen Paul, Mary E Norton
Restrictions on access to abortion in the United States have reached proportions unprecedented since the nationwide legalization of abortion in 1973. Although some restrictions aim to discourage women from having abortions, many others impede access by affecting the timeliness, affordability, or availability of services. Evidence indicates that these restrictions do not increase abortion safety; rather, they create logistic barriers for women seeking abortion, and they have the greatest effect on women with the fewest resources...
July 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27107397/reliability-of-office-based-narrow-band-imaging-guided-flexible-laryngoscopic-tissue-samplings
#19
Catherine Chang, Wan-Ni Lin, Li-Jen Hsin, Li-Ang Lee, Chien-Yu Lin, Hsueh-Yu Li, Chun-Ta Liao, Tuan-Jen Fang
OBJECTIVES/HYPOTHESIS: Direct suspension laryngoscopic biopsy performed under general anesthesia is the conventional management for obtaining pathological diagnosis for neoplasms of the larynx, oropharynx, and hypopharynx. Since the development of distal chip laryngoscopy and digital imaging systems, transnasal flexible laryngoscopy tissue sampling has gained popularity as an office-based procedure. Additional assessment with narrow-band imaging (NBI) can help to increase the diagnostic yield...
December 2016: Laryngoscope
https://www.readbyqxmd.com/read/26971682/cardiopulmonary-and-histological-characterization-of-an-acute-rat-lung-injury-model-demonstrating-safety-of-mesenchymal-stromal-cell-infusion
#20
Rudolf K Braun, Jill M Koch, Timothy A Hacker, David Pegelow, Jaehyup Kim, Amish N Raval, Eric G Schmuck, Denise J Schwahn, Derek J Hei, John M Centanni, Marlowe Eldridge, Peiman Hematti
BACKGROUND AIMS: In the field of cellular therapy, potential cell entrapment in the lungs following intravenous administration in a compromised or injured pulmonary system is an important concern that requires further investigation. We developed a rat model of inflammatory and fibrotic lung disease to mimic the human clinical condition of obliterative bronchiolitis (OB) and evaluate the safety of intravenous infusion of mesenchymal stromal cells (MSCs). This model was used to obtain appropriate safety information and functional characterization to support the translation of an ex vivo-generated cellular product into human clinical trials...
April 2016: Cytotherapy
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