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Applying wisdom

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https://www.readbyqxmd.com/read/28444384/e-science-technologies-in-a-workflow-for-personalized-medicine-using-cancer-screening-as-a-case-study
#1
Ola Spjuth, Andreas Karlsson, Mark Clements, Keith Humphreys, Emma Ivansson, Jim Dowling, Martin Eklund, Alexandra Jauhiainen, Kamila Czene, Henrik Grönberg, Pär Sparén, Fredrik Wiklund, Abbas Cheddad, Þorgerður Pálsdóttir, Mattias Rantalainen, Linda Abrahamsson, Erwin Laure, Jan-Eric Litton, Juni Palmgren
Objective: We provide an e-Science perspective on the workflow from risk factor discovery and classification of disease to evaluation of personalized intervention programs. As case studies, we use personalized prostate and breast cancer screenings. Materials and Methods: We describe an e-Science initiative in Sweden, e-Science for Cancer Prevention and Control (eCPC), which supports biomarker discovery and offers decision support for personalized intervention strategies...
April 21, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28341637/the-tax-exclusion-for-employer-sponsored-insurance-is-not-regressive-but-what-is-it
#2
Joseph White
Conventional wisdom says that the tax exclusion for employer-sponsored health insurance (ESI) is "regressive and therefore unfair." Yet, by the standard definition of regressive tax policy, the conventional view is almost certainly false. It confuses the absolute size of the tax exclusion with its proportional effect on income. The error results from paying attention only to the marginal tax rate applied to ESI benefits as a portion of income, and ignoring the fact that benefits are normally a much larger share of income for people with lower wages...
March 24, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28332881/an-individualized-approach-to-the-evaluation-and-management-of-primary-aldosteronism
#3
Anand Vaidya, Carl D Malchoff, Richard J Auchus
OBJECTIVE: With the increased emphasis on personalized and individualized medicine, the American Association of Clinical Endocrinologists Adrenal Scientific Committee has developed a series of articles to update members on personalized medicine as it applies to adrenal diseases. METHODS: Synthesis of literature review, guidelines from professional societies, and personal experience. RESULTS: Since Conn described primary aldosteronism (PA) over 60 years ago, debate has raged about the prevalence of PA in the hypertensive population, the wisdom of broadly screening for PA, and prudent approach to the evaluation and management of these patients...
March 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28328870/the-effect-of-early-life-experience-environment-and-genetic-factors-on-spontaneous-home-cage-aggression-related-wounding-in-male-c57bl-6-mice
#4
Brianna N Gaskill, Aurora M Stottler, Joseph P Garner, Christina W Winnicker, Guy B Mulder, Kathleen R Pritchett-Corning
Aggression is a major welfare issue in mice, particularly when mice unfamiliar to each other are first placed in cages, as happens on receipt from a vendor, and following cage cleaning. Injuries from aggression are the second leading cause of unplanned euthanasia in mice, following ulcerative dermatitis. Commonly employed strategies for reducing aggression-related injury are largely anecdotal, and may even be counterproductive. Here we report a series of experiments testing potential explanations and interventions for post-shipping aggression-related injuries in C57BL/6 mice...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328209/multidk-a-multiple-descriptor-multiple-kernel-approach-for-molecular-discovery-and-its-application-to-organic-flow-battery-electrolytes
#5
Sungjin Kim, Adrián Jinich, Alán Aspuru-Guzik
We propose a multiple descriptor multiple kernel (MultiDK) method for efficient molecular discovery using machine learning. We show that the MultiDK method improves both the speed and accuracy of molecular property prediction. We apply the method to the discovery of electrolyte molecules for aqueous redox flow batteries. Using multiple-type-as opposed to single-type-descriptors, we obtain more relevant features for machine learning. Following the principle of "wisdom of the crowds", the combination of multiple-type descriptors significantly boosts prediction performance...
April 24, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28253883/systematic-development-and-implementation-of-interventions-to-optimise-health-literacy-and-access-ophelia
#6
Alison Beauchamp, Roy W Batterham, Sarity Dodson, Brad Astbury, Gerald R Elsworth, Crystal McPhee, Jeanine Jacobson, Rachelle Buchbinder, Richard H Osborne
BACKGROUND: The need for healthcare strengthening to enhance equity is critical, requiring systematic approaches that focus on those experiencing lesser access and outcomes. This project developed and tested the Ophelia (OPtimising HEalth LIteracy and Access) approach for co-design of interventions to improve health literacy and equity of access. Eight principles guided this development: Outcomes focused; Equity driven, Needs diagnosis, Co-design, Driven by local wisdom, Sustainable, Responsive and Systematically applied...
March 3, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28245078/identification-of-huoshan-shihu-fengdou-comparative-authentication-of-the-daodi-herb-dendrobium-huoshanense-and-its-related-species-by-macroscopic-and-microscopic-features
#7
Yujiao Zhao, Bangxing Han, Huasheng Peng, Xiao Wang, Shanshan Chu, Jun Dai, Daiyin Peng
"Huoshan shihu," derived from Dendrobium huoshanense, is a well-known, valuable, and rare Daodi herb. Because of its higher price and scarce resources, its related species D. officinale and D. moniliforme are usually presented as "Huoshan shihu" for sale. Fengdou, the processed form of D. huoshanense, its identification is particularly important. To effectively identify Fengdou of D. huoshanense and protect the Daodi herb, the morphological and microscopic characteristics of the stems of three Dendrobium species were examined...
February 28, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28167340/knowledge-and-power-in-policy-making-for-child-survival-in-niger
#8
Sarah L Dalglish, Daniela C Rodríguez, Abdoutan Harouna, Pamela J Surkan
Calls to enhance the use of scientific evidence in international health and development policy have increased in recent years; however, analytic frameworks for understanding evidence use focus narrowly on scientific research and were created using data and observations nearly exclusively from Western countries. We examine processes of health policy development in a case study of Niger, a low-income West African country that adopted integrated community case management of childhood illness (iCCM) beginning in 2007, resulting in measurable declines in child mortality...
January 30, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28144974/thinking-about-the-patient-s-wishes-practical-wisdom-of-discharge-planning-nurses-in-assisting-surrogate-decision-making
#9
Yoko Kageyama, Midori Asano
BACKGROUND: The accelerating trend towards shorter hospital stays in Japan has made modes of decision-making essential for effective patient transition from the hospital to recuperation in the regional community, and the ageing of the population has brought a rise in surrogate decision-making by the families of patients lacking decision-making ('self-decision') capacity. AIM: To verbalise and elucidate the practical wisdom of discharge planning nurses by focusing on the perceptions and judgements, they apply in practice and describing their methodology in concrete terms...
January 31, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28128245/a-solution-to-the-single-question-crowd-wisdom-problem
#10
Dražen Prelec, H Sebastian Seung, John McCoy
Once considered provocative, the notion that the wisdom of the crowd is superior to any individual has become itself a piece of crowd wisdom, leading to speculation that online voting may soon put credentialed experts out of business. Recent applications include political and economic forecasting, evaluating nuclear safety, public policy, the quality of chemical probes, and possible responses to a restless volcano. Algorithms for extracting wisdom from the crowd are typically based on a democratic voting procedure...
January 25, 2017: Nature
https://www.readbyqxmd.com/read/28116438/-comparison-of-minimally-invasive-extraction-and-traditional-method-in-the-extraction-of-impacted-mandibular-third-molar
#11
Fang Xu, Hui-Xia Zhang
PURPOSE: To compare minimally invasive extraction and traditional method in the extraction of impacted mandibular third molar. METHODS: One hundred and sixty patients with impacted mandibular third molar were equally divided into two groups. Patients in the experimental group were treated with minimally invasive extraction, using implant machine and luxator, while patients in the control group were treated with traditional methods including use of orthodox chisel...
October 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28090681/excess-of-exercise-increases-the-risk-of-atrial-fibrillation
#12
REVIEW
A Müssigbrodt, A Weber, J Mandrola, Y van Belle, S Richter, M Döring, A Arya, P Sommer, A Bollmann, G Hindricks
An interesting and still not well-understood example for old medical wisdom "Sola dosis facit venenum" is the increased prevalence of atrial fibrillation (AF) in athletes. Numerous studies have shown a fourfold to eightfold increased risk of AF in athletes compared to the normal population. Analysis of the existing data suggests a dose-dependent effect of exercise. Moderate exercise seems to have a protective effect and decreases the risk of AF, whereas excessive exercise seems to increase the risk of AF. The described cases illustrate clinical manifestations within the spectrum of AF in elderly athletes, that is, exercise-induced AF, vagal AF, chronic AF, and atrial flutter...
January 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28057049/combined-use-of-the-consolidated-framework-for-implementation-research-cfir-and-the-theoretical-domains-framework-tdf-a-systematic-review
#13
REVIEW
Sarah A Birken, Byron J Powell, Justin Presseau, M Alexis Kirk, Fabiana Lorencatto, Natalie J Gould, Christopher M Shea, Bryan J Weiner, Jill J Francis, Yan Yu, Emily Haines, Laura J Damschroder
BACKGROUND: Over 60 implementation frameworks exist. Using multiple frameworks may help researchers to address multiple study purposes, levels, and degrees of theoretical heritage and operationalizability; however, using multiple frameworks may result in unnecessary complexity and redundancy if doing so does not address study needs. The Consolidated Framework for Implementation Research (CFIR) and the Theoretical Domains Framework (TDF) are both well-operationalized, multi-level implementation determinant frameworks derived from theory...
January 5, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28056403/being-smart-about-writing-smart-objectives
#14
May Britt Bjerke, Ralph Renger
This article challenges the conventional wisdom in mainstream evaluation regarding the process for developing specific, measurable, attainable, relevant, and time-bound (SMART) objectives. The article notes several advantages of mainstreaming the SMART method including program capacity building and being able to independently monitor progress toward process and outcome objectives. It is argued the one size fits all approach for writing SMART objectives is misleading. The context in which the evaluation is conducted is a key deciding factor in how and when the SMART criteria should be applied...
December 23, 2016: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28046240/we-h-brc-05-catastrophic-error-metrics-for-radiation-therapy
#15
S Murphy, J Molloy
PURPOSE: Intuitive evaluation of complex radiotherapy treatments is impractical, while data transfer anomalies create the potential for catastrophic treatment delivery errors. Contrary to prevailing wisdom, logical scrutiny can be applied to patient-specific machine settings. Such tests can be automated, applied at the point of treatment delivery and can be dissociated from prior states of the treatment plan, potentially revealing errors introduced early in the process. METHODS: Analytical metrics were formulated for conventional and intensity modulated RT (IMRT) treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27975042/predictive-values-derived-from-lower-wisdom-teeth-developmental-stages-on-orthopantomograms-to-calculate-the-chronological-age-in-adolescence-and-young-adults-as-a-prerequisite-to-obtain-age-adjusted-informed-patient-consent-prior-to-elective-surgical-procedures
#16
Reinhard E Friedrich, Kirsten Schmidt, András Treszl, Jan F Kersten
Introduction: Surgical procedures require informed patient consent, which is mandatory prior to any procedure. These requirements apply in particular to elective surgical procedures. The communication with the patient about the procedure has to be comprehensive and based on mutual understanding. Furthermore, the informed consent has to take into account whether a patient is of legal age. As a result of large-scale migration, there are eventually patients planned for medical procedures, whose chronological age can't be assessed reliably by physical inspection alone...
2016: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/27879112/machine-learning-of-swimming-data-via-wisdom-of-crowd-and-regression-analysis
#17
Jiang Xie, Junfu Xu, Celine Nie, Qing Nie
Every performance, in an officially sanctioned meet, by a registered USA swimmer is recorded into an online database with times dating back to 1980. For the first time, statistical analysis and machine learning methods are systematically applied to 4,022,631 swim records. In this study, we investigate performance features for all strokes as a function of age and gender. The variances in performance of males and females for different ages and strokes were studied, and the correlations of performances for different ages were estimated using the Pearson correlation...
April 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27873413/six-degrees-of-separation-the-small-world-of-medical-education
#18
Wolf E Hautz, Gert Krummrey, Aristomenis Exadaktylos, Stefanie C Hautz
CONTEXT: Conventional wisdom has it that everyone on earth is on average only six steps away from knowing any other person through 'a friend of a friend'. On a local level, however, many people experience that most of their acquaintances know each other. It is thus hard to imagine how such a highly clustered group could be so well connected to the rest of the world. In this paper, we investigate how co-authorship connects scholars in medical education and whether the six degrees of separation hypothesis also applies to the network of authors in the field...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27853292/toward-an-understanding-of-wisdom-in-nursing
#19
Susan A Matney, Kay Avant, Nancy Staggers
As nurses, we seek to better understand how to gain nursing ‘wisdom’ and apply this wisdom in our daily practice. Yet the concept and experience of ‘wisdom in nursing practice’ has not been well defined. This article addresses wisdom-in-action for nursing practice. We briefly describe nursing theory, review the wisdom literature as presented in various disciplines, and identify characteristics of wisdom by analyzing four models of wisdom from other disciplines. We also present the ten antecedents of wisdom and the ten characteristics of wisdom identified in our analysis of the wisdom literature, discuss and summarize these antecedents, and conclude that understanding these ten antecedents and the ten characteristics of wisdom-in-action can both help nurses demonstrate wisdom as they provide nursing care and teach new nurses the process of becoming wise in nursing practice...
October 30, 2015: Online Journal of Issues in Nursing
https://www.readbyqxmd.com/read/27754975/combining-regression-and-mean-comparisons-to-identify-the-time-course-of-changes-in-neuromuscular-responses-during-the-process-of-fatigue
#20
Cory M Smith, Terry J Housh, Nathaniel D M Jenkins, Ethan C Hill, Kristen C Cochrane, Amelia A Miramonti, Richard J Schmidt, Glen O Johnson
The purposes of the present study were to apply a unique method for the identification of the time course of changes in neuromuscular responses and to infer the motor unit activation strategies used to maintain force during a fatiguing, intermittent isometric workbout. Eleven men performed 50, 6 s intermittent isometric muscle actions of the leg extensors, each separated by 2 s of rest at 60% maximal voluntary isometric contraction (MVIC). Electromyographic (EMG) and mechanomyographic (MMG) amplitude (root mean square; RMS) and frequency (mean power frequency; MPF) were obtained from the vastus lateralis (VL) every 5 of the 50 repetitions and normalized as a percent of the initial repetition...
October 18, 2016: Physiological Measurement
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