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https://www.readbyqxmd.com/read/29130584/long-term-outcomes-after-reirradiation-in-nasopharyngeal-carcinoma-with-intensity-modulated-radiotherapy-a-meta-analysis
#1
REVIEW
Yiat Horng Leong, Yu Yang Soon, Khai Mun Lee, Lea Choung Wong, Ivan Weng Keong Tham, Francis Cho Hao Ho
BACKGROUND: The purpose of this clinical review was to summate the published data for the long-term outcomes of reirradiation with intensity-modulated radiotherapy (IMRT) for locally recurrent nasopharyngeal carcinoma (NPC). METHODS: We searched biomedical literature databases for eligible studies published from January 2005 to September 2016. Outcomes of interests were 5-year local failure-free survival, distant failure-free survival, overall survival (OS), and toxicities...
November 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29128197/reirradiation-of-gliomas-under-stereotactic-conditions-prognostic-factors-for-survival-without-relapse-or-side-effects-a-retrospective-study-at-tours-regional-university-hospital-france
#2
S Lévy, S Chapet, N Scher, K Debbi, A Ruffier, G Bernadou, Y Pointreau, G Calais
PURPOSE: To search for factors correlated with relapse-free survival following stereotactic reirradiation in patients with recurrent glioma following radiochemotherapy and evaluate tolerance to this treatment. PATIENTS AND METHODS: Initial radiotherapy was given according to the protocol of Stupp and al. Reirradiation was performed using the CyberKnife(®) system. Patients could have had surgical resection initially and at the time of recurrence. We analysed 13 patients treated between July 2010 and September 2014...
November 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29114615/risk-of-carotid-blowout-after-reirradiation-with-particle-therapy
#3
Jon Espen Dale, Silvia Molinelli, Elisa Ciurlia, Mario Ciocca, Maria Bonora, Viviana Vitolo, Alfredo Mirandola, Stefania Russo, Roberto Orecchia, Olav Dahl, Piero Fossati
Purpose: Carotid blowout (CB) is a serious complication in retreatment of neoplasms in the head and neck (H&N) region. Rates seem to increase in hypofractionated or accelerated hyperfractionated regimens. In this study, we investigate the CB rate and the cumulative doses received by the carotid artery (CA) in a cohort of patients who were reirradiated at CNAO with particle therapy in the H&N region. Methods and materials: The dosimetric information, medical records, and tumor characteristics of 96 patients were analyzed...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114606/estimating-prognosis-at-the-time-of-repeat-whole-brain-radiation-therapy-for-multiple-brain-metastases-the-reirradiation-score
#4
Natalie Logie, Rachel B Jimenez, Natalie Pulenzas, Kelly Linden, Denise Ciafone, Sunita Ghosh, Yuhui Xu, Shilo Lefresne, Erin Wong, Christina H Son, Helen A Shih, William W Wong, Scott Tyldesley, Kristopher Dennis, Edward Chow, Alysa M Fairchild
Purpose: Whole brain radiation therapy (WBRT) remains the standard of care for patients with multiple brain metastases, but more than half of treated patients will develop intracranial progression. Because there is no clear consensus on the optimal therapeutic approach, a prognostic index would be helpful to guide treatment options at progression. We explored whether the recursive partitioning analysis (RPA) score prior to repeat WBRT is predictive of survival. Methods and materials: This multi-institutional pooled analysis included patients with 2 or more brain metastases from any solid primary tumor that was treated with 2 courses of WBRT...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29102648/investigating-the-effect-of-reirradiation-or-systemic-therapy-in-patients-with-glioblastoma-after-tumor-progression-a-secondary-analysis-of-nrg-oncology-radiation-therapy-oncology-group-trial-0525
#5
Wenyin Shi, Molly Scannell Bryan, Mark R Gilbert, Minesh P Mehta, Deborah T Blumenthal, Paul D Brown, Egils Valeinis, Kirsten Hopkins, Luis Souhami, David W Andrews, Tzahala Tzuk-Shina, Steve P Howard, Emad F Youssef, Nathalie Lessard, James J Dignam, Maria Werner-Wasik
PURPOSE: To determine the impact on overall survival with different salvage therapies, including no treatment, reirradiation, systemic therapy, or radiation and systemic therapy, in participants of a phase 3 clinical trial evaluating dose-dense versus standard-dose temozolomide for patients with newly diagnosed glioblastoma. METHODS AND MATERIALS: This analysis of patients from Trial RTOG 0525 investigated the effect of reirradiation or systemic treatment after tumor progression...
September 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29080990/reirradiation-of-skull-base-tumors-with-advanced-highly-conformal-techniques
#6
REVIEW
Jennifer C Ho, Jack Phan
PURPOSE OF REVIEW: Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancements, such as image-guided radiation therapy (IGRT), intensity-modulated radiation therapy (IMRT), particle therapy, and stereotactic radiation therapy (SRT), are attractive for skull base reirradiation...
October 28, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/29057779/reirradiation
#7
Ryoong-Jin Oh
No abstract text is available yet for this article.
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29029888/reirradiation-using-permanent-interstitial-brachytherapy-a-potentially-durable-technique-for-salvaging-recurrent-pelvic-malignancies
#8
Jonathan Feddock, Dennis Cheek, Cole Steber, Jason Edwards, Stacey Slone, Wei Luo, Marcus Randall
PURPOSE: To present a time-to-failure (TTF) analysis for all patients treated with permanent interstitial brachytherapy (PIB) at our institution, with additional analyses to correlate successful reirradiation and to identify the frequency of severe grade 3 to 4 toxicity. METHODS AND MATERIALS: Forty-two previously irradiated patients received curative or palliative intent PIB for a recurrent pelvic malignancy between January 2009 and August 2016. Minimum follow-up was 6 months after the PIB procedure...
August 26, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29029887/long-term-clinical-safety-of-high-dose-proton-radiation-therapy-delivered-with-pencil-beam-scanning-technique-for-extracranial-chordomas-and-chondrosarcomas-in-adult-patients-clinical-evidence-of-spinal-cord-tolerance
#9
Sonja Stieb, James W Snider, Lorenzo Placidi, Ulrike Kliebsch, Anthony J Lomax, Ralf A Schneider, Damien C Weber
PURPOSE: To assess the radiation dose tolerance of the spinal cord by reviewing our institutional experience regarding the incidence of radiation-induced spinal cord toxicity after high-dose pencil beam scanning proton therapy (PBSPT). METHODS AND MATERIALS: Seventy-six patients (median age 53 years; range, 23-79 years) treated for spinal chordoma (n=55) or chondrosarcoma (n=21) met the following criteria and were retrospectively analyzed: PBSPT only, no reirradiation or concomitant chemotherapy, maximum dose (Dmax) to the spinal cord of ≥45 Gy(relative biological effectiveness [RBE]), ≥18 years of age, and follow-up of ≥12 months...
September 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28990255/role-of-surgery-in-the-treatment-of-osteoradionecrosis-and-its-complications-after-radiotherapy-for-nasopharyngeal-carcinoma
#10
Wen Bo Huang, Stanley Thian Sze Wong, Jimmy Yu Wai Chan
BACKGROUND: The purpose of this study was to review the efficacy of surgery for patients with osteoradionecrosis (ORN) after radiotherapy for nasopharyngeal carcinoma (NPC). METHODS: Between 2000 and 2016, we identified 162 patients with skull base ORN, among which 58 patients required surgery. A retrospective medical chart review was performed and the indications and results of surgical interventions were recorded. RESULTS: All surgeries were performed for the treatment of secondary complications of ORN, including central nervous system (CNS) infection (48...
October 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28974415/hypofractionated-stereotactic-radiation-therapy-to-the-resection-bed-for-intracranial-metastases
#11
Audrey Keller, Mélanie Doré, Hélène Cebula, François Thillays, François Proust, Ioana Darié, Stéphane-André Martin, Gregory Delpon, François Lefebvre, Georges Noël, Delphine Antoni
PURPOSE: To retrospectively report the outcomes of a large multicenter cohort of patients treated with surgery and hypofractionated stereotactic radiation therapy (HFSRT) to the resection cavities of brain metastases (BMs). METHODS AND MATERIALS: Between March 2008 and February 2015, 181 patients with no prior whole-brain radiation therapy (WBRT) were treated by HFSRT to the surgical bed of BM at the dose of 33 Gy (3 × 11 Gy). The primary endpoint was local control...
August 19, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28943681/robust-treatment-comparison-based-on-utilities-of-semi-competing-risks-in-non-small-cell-lung-cancer
#12
Thomas A Murray, Peter F Thall, Ying Yuan, Sarah McAvoy, Daniel R Gomez
A design is presented for a randomized clinical trial comparing two second-line treatments, chemotherapy versus chemotherapy plus reirradiation, for treatment of recurrent non-small-cell lung cancer. The central research question is whether the potential efficacy benefit that adding reirradiation to chemotherapy may provide justifies its potential for increasing the risk of toxicity. The design uses two co-primary outcomes: time to disease progression or death, and time to severe toxicity. Because patients may be given an active third-line treatment at disease progression that confounds second-line treatment effects on toxicity and survival following disease progression, for the purpose of this comparative study follow-up ends at disease progression or death...
2017: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/28941560/systematic-assessment-of-clinical-outcomes-and-toxicities-of-proton-radiotherapy-for-reirradiation
#13
REVIEW
Vivek Verma, Jean-Claude M Rwigema, Robert S Malyapa, William F Regine, Charles B Simone
Reirradiation (reRT) for locoregional recurrences poses unique challenges and risks; re-treatment using proton beam radiotherapy (PBT) could prove advantageous. Assessing clinical outcomes and toxicity profiles, this systematic review comprehensively evaluated available evidence regarding PBT reRT. Fourteen original investigations across central nervous system (CNS) (n=6), head/neck (H&N) (n=4), lung (n=2), and gastrointestinal (n=2) malignancies were analyzed. PBT for recurrent uveal melanoma achieved 5-year eye retention of 55%; for chordomas, reRT afforded a 2-year local control and overall survival (OS) of 85% and 80%, respectively...
October 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28939070/patient-oriented-toxicity-endpoints-after-head-and-neck-reirradiation-with-intensity-modulated-radiation-therapy
#14
Danielle N Margalit, Jonathan D Schoenfeld, Bhupendra Rawal, Robert I Haddad, Paul J Catalano, Laura A Goguen, Nicole G Chau, Guilherme Rabinowits, Jochen H Lorch, Donald J Annino, Roy B Tishler
OBJECTIVES: To characterize specific serious toxicities of reRT with intensity modulated radiation therapy (IMRT) for squamous cell carcinoma of the head and neck (SCCHN) and identify treatment-related predictors of toxicity for patient counseling and decision-making. MATERIALS/METHODS: 75 consecutive patients with recurrent or 2nd primary SCCHN received reRT from 8/2004-02/2013. All patients had prior definitive or postoperative RT. Objective endpoints of "serious toxicity" were defined as: hospitalization during reRT, tracheotomy after reRT, hemorrhage, soft tissue complication requiring operative intervention, or other CTCAE grade ≥4 toxicity...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28917253/re-irradiation-with-stereotactic-body-radiation-therapy-sbrt
#15
Morten Høyer
Stereotactic body radiation therapy (SBRT) is a potential treatment option for patients who develop a relapse within or marginal to a previously irradiated volume, but it seems underused because of sparse knowledge on the efficacy and morbidity related to the treatment. Normal tissues often recover some of the damage caused by the primary radiotherapy with time, but the kinetics of recovery is not clearly described in the literature. There is a growing number of publications on SBRT reirradiation, but the literature consists mainly of retrospective cohort studies...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28903447/locoregionally-recurrent-head-and-neck-squamous-cell-carcinoma-incidence-survival-prognostic-factors-and-treatment-outcomes
#16
Jer-Hwa Chang, Chia-Che Wu, Kevin Sheng-Po Yuan, Alexander T H Wu, Szu-Yuan Wu
PURPOSE: For locoregionally recurrent head and neck squamous cell carcinoma (HNSCC), appropriate therapeutic decisions remain unclear. We examined the treatment outcomes of a national cohort to determine suitable treatments for and prognostic factors in patients with locoregionally recurrent HNSCCs at different stages and sites. PATIENTS AND METHODS: We analyzed data of >20-year-old patients with HNSCC at American Joint Committee on Cancer clinical stages I-IV without metastasis from Taiwan National Health Insurance and cancer registry databases...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28899556/a-multi-institutional-comparison-of-sbrt-and-imrt-for-definitive-reirradiation-of-recurrent-or-second-primary-head-and-neck-cancer
#17
John A Vargo, Matthew C Ward, Jimmy J Caudell, Nadeem Riaz, Neal E Dunlap, Derek Isrow, Sara J Zakem, Joshua Dault, Musaddiq J Awan, Kristin A Higgins, Comron Hassanadeh, Jonathan J Beitler, Chandana A Reddy, Samuel Marcrom, Drexell H Boggs, James A Bonner, Min Yao, Mitchell Machtay, Farzan Siddiqui, Andy M Trotti, Nancy Y Lee, Shlomo A Koyfman, Robert L Ferris, Dwight E Heron
PURPOSE: Two modern methods of reirradiation, intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), are established for patients with recurrent or second primary squamous cell carcinoma of the head and neck (rSCCHN). We performed a retrospective multi-institutional analysis to compare methods. METHODS AND MATERIALS: Data from patients with unresectable rSCCHN previously irradiated to ≥40 Gy who underwent reirradiation with IMRT or SBRT were collected from 8 institutions...
April 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28894694/evaluation-of-partial-breast-reirradiation-with-intraoperative-radiotherapy-after-prior-thoracic-radiation-a-single-institution-report-of-outcomes-and-toxicity
#18
Christine Chin, Priya Jadeja, Bret Taback, David P Horowitz, Sheldon M Feldman, Richard Ha, Eileen P Connolly
INTRODUCTION: Mastectomy is the current standard of care for ipsilateral breast tumor recurrences after prior whole breast irradiation (WBI). We report our single-institution experience with breast-conserving surgery (BCS) followed by intraoperative radiotherapy (IORT) as an alternative to salvage mastectomy for new or recurrent breast cancers that develop in the setting of prior thoracic radiation. METHODS: We performed an IRB-approved retrospective review of patients treated with breast IORT between September 2013 and November 2016...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28890817/proton-beam-reirradiation-for-locally-recurrent-pancreatic-adenocarcinoma
#19
Pamela J Boimel, Abigail T Berman, Jonathan Li, Smith Apisarnthanarax, Stefan Both, Kristi Lelionis, Gary L Larson, Ursina Teitelbaum, John N Lukens, Edgar Ben-Josef, James M Metz, John P Plastaras
BACKGROUND: Local recurrence following definitive treatment for pancreatic adenocarcinoma is common and can be associated with significant morbidity and mortality. Retreatment options for these patients are limited. Proton beam reirradiation (PRT) may limit dose and toxicity to previously irradiated normal tissues in patients without evidence of metastatic disease. METHODS: Between 8/2010-2/2015, 15 patients with isolated, locally-recurrent pancreatic cancer were treated with PRT...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890088/management-of-local-relapse-after-prostate-cancer-radiotherapy-surgery-or-radiotherapy
#20
REVIEW
C Hennequin, J-M Hannoun-Lévi, F Rozet
Isolated local relapse after prostate cancer radiotherapy corresponds to 40% of biochemical failure. The management of these relapses is not well defined. Several strategies are available including surgery, high-intensity focused ultrasounds (HIFU), cryotherapy and reirradiation. Radical prostatectomy is the historical approach; biochemical control is obtained in 50 to 80% at 5 year. However, morbidity is higher after irradiation than as a first line treatment. Some limited series of HIFU and cryotherapy have been published with interesting results, but again the risk of urinary and rectal toxicity is high...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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