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https://www.readbyqxmd.com/read/28721885/nrg-oncology-radiation-therapy-oncology-group-study-1014-1-year-toxicity-report-from-a-phase-2-study-of-repeat-breast-preserving-surgery-and-3-dimensional-conformal-partial-breast-reirradiation-for-in-breast-recurrence
#1
Douglas W Arthur, Kathryn A Winter, Henry M Kuerer, Bruce G Haffty, Laurie W Cuttino, Dorin A Todor, Nicole L Simone, Shelly B Hayes, Wendy A Woodward, Beryl McCormick, Randi J Cohen, Walter M Sahijdak, Daniel J Canaday, Doris R Brown, Adam D Currey, Christine M Fisher, Reshma Jagsi, Julia White
PURPOSE: To determine the associated toxicity, tolerance, and safety of partial-breast reirradiation. METHODS AND MATERIALS: Eligibility criteria included in-breast recurrence occurring >1 year after whole-breast irradiation, <3 cm, unifocal, and resected with negative margins. Partial-breast reirradiation was targeted to the surgical cavity plus 1.5 cm; a prescription dose of 45 Gy in 1.5 Gy twice daily for 30 treatments was used. The primary objective was to evaluate the rate of grade ≥3 treatment-related skin, fibrosis, and/or breast pain adverse events (AEs), occurring ≤1 year from re-treatment completion...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28708043/reirradiation-spine-stereotactic-body-radiation-therapy-for-spinal-metastases-systematic-review
#2
Sten Myrehaug, Arjun Sahgal, Motohiro Hayashi, Marc Levivier, Lijun Ma, Roberto Martinez, Ian Paddick, Jean Régis, Samuel Ryu, Ben Slotman, Antonio De Salles
OBJECTIVE Spinal metastases that recur after conventional palliative radiotherapy have historically been difficult to manage due to concerns of spinal cord toxicity in the retreatment setting. Spine stereotactic body radiation therapy (SBRT), also known as stereotactic radiosurgery, is emerging as an effective and safe means of delivering ablative doses to these recurrent tumors. The authors performed a systematic review of the literature to determine the clinical efficacy and safety of spine SBRT specific to previously irradiated spinal metastases...
July 14, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28697854/a-prospective-study-of-proton-reirradiation-for-recurrent-and-secondary-soft-tissue-sarcoma
#3
David M Guttmann, Melissa A Frick, Ruben Carmona, Curtiland Deville, William P Levin, Abigail T Berman, Chidambaram Chinniah, Stephen M Hahn, John P Plastaras, Charles B Simone
BACKGROUND AND PURPOSE: Proton reirradiation for sarcoma has not been previously described. We hypothesized that this strategy would provide favorable toxicity and survival outcomes. MATERIAL AND METHODS: Patients with soft tissue sarcoma in a previously-irradiated field were enrolled on a prospective trial of proton reirradiation. The primary endpoint was provider-reported acute toxicity. Secondary endpoints included late toxicities, local control, and overall survival...
July 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28673511/reirradiation-of-the-spine-with-stereotactic-radiosurgery-efficacy-and-toxicity
#4
David Boyce-Fappiano, Erinma Elibe, Bo Zhao, M Salim Siddiqui, Ian Lee, Jack Rock, Samuel Ryu, Farzan Siddiqui
PURPOSE: To determine the potential benefits and adverse effects associated with reirradiating the spinal cord when at least 1 course of radiation therapy (RT) is stereotactic radiosurgery (SRS). METHODS AND MATERIALS: This institutional review board-approved retrospective review included 162 patients (237 reirradiated spine lesions). All patients received SRS at our institution between 2001 and 2013. Electronic medical records were reviewed for clinical exams and radiologic tests (computed tomography/magnetic resonance imaging)...
May 25, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28666902/intensity-modulated-radiation-therapy-with-pulsed-reduced-dose-rate-as-a-reirradiation-strategy-for-recurrent-central-nervous-system-tumors-an-institutional-series-and-literature-review
#5
Erin S Murphy, Kevin Rogacki, Andrew Godley, Peng Qi, Chandana A Reddy, Manmeet S Ahluwalia, David M Peereboom, Glen H Stevens, Jennifer S Yu, Rupesh Kotecha, John H Suh, Samuel T Chao
BACKGROUND: Pulsed reduced dose rate (PRDR) is a reirradiation technique that potentially overcomes volume and dose limitations in the setting of previous radiation therapy for recurrent central nervous system (CNS) tumors. Intensity modulated radiation therapy (IMRT) has not yet been reported as a PRDR delivery technique. We reviewed our IMRT PRDR outcomes and toxicity and reviewed the literature of available PRDR series for CNS reirradiation. METHODS AND MATERIALS: A total of 24 patients with recurrent brain tumors received PRDR reirradiation between August 2012 and December 2014...
April 12, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28663716/reirradiation-with-imrt-for-recurrent-head-and-neck-cancer-a-single-institutional-report-on-disease-control-survival-and-toxicity
#6
Parveen Ahlawat, Sheh Rawat, Anjali Kakria, Bharti Devnani, Inderjit Kaur Wahi, David K Simson
AIM: To study and explores the feasibility and efficacy of re-irradiation (Re-RT) for locally recurrent head and neck cancer (HNC) and second primary (SP) malignancies. BACKGROUND: The most common form of treatment failure after radiotherapy (RT) for HNC is loco-regional recurrence (LRR), and around 20-50% of patients develop LRR. Re-irradiation (Re-RT) has been the primary standard of care in the last decade for unresectable locally recurrent/SP HNC. MATERIALS AND METHODS: It was a retrospective analysis in which we reviewed the medical records of 51 consecutive patients who had received Re-RT to the head and neck region at our institute between 2006 and 2015...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28623436/high-dose-rate-brachytherapy-as-salvage-modality-for-locally-recurrent-prostate-cancer-after-definitive-radiotherapy-a%C3%A2-systematic-review
#7
REVIEW
Georgios Chatzikonstantinou, Nikolaos Zamboglou, Claus Rödel, Eleni Zoga, Iosif Strouthos, Saeed Ahmed Butt, Nikolaos Tselis
PURPOSE: To review the current status of interstitial high-dose-rate brachytherapy as a salvage modality (sHDR BRT) for locally recurrent prostate cancer after definitive radiotherapy (RT). MATERIALS AND METHODS: A literature search was performed in PubMed using "high-dose-rate, brachytherapy, prostate cancer, salvage" as search terms. In all, 51 search results published between 2000 and 2016 were identified. Data tables were generated and summary descriptions created...
June 16, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28587057/safety-and-efficacy-of-stereotactic-ablative-radiation-therapy-for-renal-cell-carcinoma-extracranial-metastases
#8
Chiachien Jake Wang, Alana Christie, Mu-Han Lin, Matthew Jung, Derek Weix, Lorel Huelsmann, Kristin Kuhn, Jeffrey Meyer, Neil Desai, D W Nathan Kim, Ivan Pedrosa, Vitaly Margulis, Jeffrey Cadeddu, Arthur Sagalowsky, Jeffrey Gahan, Aaron Laine, Xian-Jin Xie, Hak Choy, James Brugarolas, Robert Timmerman, Raquibul Hannan
PURPOSE: Renal cell carcinoma is refractory to conventional radiation therapy but responds to higher doses per fraction. However, the dosimetric data and clinical factors affecting local control (LC) are largely unknown. We aimed to evaluate the safety and efficacy of stereotactic ablative radiation therapy (SAbR) for extracranial renal cell carcinoma metastases. METHODS AND MATERIALS: We reviewed 175 metastatic lesions from 84 patients treated with SAbR between 2005 and 2015...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28587056/tolerance-of-the-brachial-plexus-to-high-dose-reirradiation
#9
Allen M Chen, Taeko Yoshizaki, Maria A Velez, Argin G Mikaeilian, Sophia Hsu, Minsong Cao
PURPOSE: To study the tolerance of the brachial plexus to high doses of radiation exceeding historically accepted limits by analyzing human subjects treated with reirradiation for recurrent tumors of the head and neck. METHODS AND MATERIALS: Data from 43 patients who were confirmed to have received overlapping dose to the brachial plexus after review of radiation treatment plans from the initial and reirradiation courses were used to model the tolerance of this normal tissue structure...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28586972/reirradiation-of-thoracic-cancers-with-intensity-modulated-proton-therapy
#10
J C Ho, Q N Nguyen, H Li, P K Allen, X Zhang, X R Zhu, D R Gomez, S H Lin, M T Gillin, R U Komaki, Z Liao, S M Hahn, J Y Chang
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28566248/-prognostic-factors-for-head-and-neck-cancer-reirradiation-a-systematic-review
#11
REVIEW
T Ohnleiter, P Truntzer, D Antoni, S Guihard, A-M Elgard, G Noël
PURPOSE: To specify the effectiveness of head and neck cancer reirradiation and make a synthesis of prognostic factors established by published series of patients. MATERIALS AND METHODS: Original series of external reirradiation of head and neck cancer with at least ten patients were sought in Medline database. RESULTS: Exclusive reirradiation with or without concurrent chemotherapy offers 11 months of median overall survival, versus 6 months for chemotherapy alone, and 20 to 40% of the patients are still alive two years after treatment...
June 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28551390/potential-abscopal-response-to-dual-checkpoint-blockade-in-rcc-after-reirradiation-using-dose-painting-sbrt
#12
Quincey LaPlant, Carl Deselm, Natalie A Lockney, James Hsieh, Yoshiya Yamada
No abstract text is available yet for this article.
April 18, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28536486/emerging-indications-for-fractionated-gamma-knife-radiosurgery
#13
Emory McTyre, Corbin A Helis, Michael Farris, Lisa Wilkins, Darrell Sloan, William H Hinson, J Daniel Bourland, William A Dezarn, Michael T Munley, Kounosuke Watabe, Fei Xing, Adrian W Laxton, Stephen B Tatter, Michael D Chan
BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree of dose conformality and precision. There are, however, certain situations wherein the dose conformality of GKRS is desired, but single session treatment is contraindicated. In these situations, a traditional pin-based GKRS head frame cannot be used, as it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients with fractionated GKRS using a relocatable, noninvasive immobilization system...
February 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28529895/special-topics-in-immunotherapy-and-radiation-therapy-reirradiation-and-palliation
#14
REVIEW
Tracey Evans, Christine Ciunci, Lauren Hertan, Daniel Gomez
Immunotherapy has revolutionized the treatment of non-small cell lung cancer (NSCLC). However, thus far, its use has only been established in patients with advanced disease either as first-line therapy in selected patients or following chemotherapy. What is not yet known is how best to incorporate radiation with immunotherapy agents. Many patients with advanced disease can benefit from palliative radiation, but the combination of radiation with immunotherapy has the potential to increase the toxicity of both modalities...
April 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28489796/leptomeningeal-metastasis-of-poorly-differentiated-uterine-cervical-adenosquamous-carcinoma-following-reirradiation-to-metastatic-vertebrae-a-case-report
#15
Yueh-Feng Lu, Vai Hong Fong, Wen-Yih Wu, Li-Ying Wang, Chen-Hsi Hsieh
RATIONALE: Leptomeningeal metastasis from cervical adenosquamous carcinoma is extremely rare especially after radiotherapy for vertebral metastasis. PATIENT CONCERNS: A 52-year-old woman with International Federation of Gynecology and Obstetrics (FIGO) stage IIB adenosquamous carcinoma of cervix presented with bilateral lower limbs weakening after 2 courses radiotherapy to thoracic vertebral metastases. DIAGNOSES: Initial spine magnetic resonance imaging (MRI) showed no obvious nerve compression, and radiation myelopathy was suspected by the clinician...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28472925/registration-error-of-the-liver-ct-using-deformable-image-registration-of-mim-maestro-and-velocity-ai
#16
Nobuyoshi Fukumitsu, Kazunori Nitta, Toshiyuki Terunuma, Toshiyuki Okumura, Haruko Numajiri, Yoshiko Oshiro, Kayoko Ohnishi, Masashi Mizumoto, Teruhito Aihara, Hitoshi Ishikawa, Koji Tsuboi, Hideyuki Sakurai
BACKGROUND: Understanding the irradiated area and dose correctly is important for the reirradiation of organs that deform after irradiation, such as the liver. We investigated the spatial registration error using the deformable image registration (DIR) software products MIM Maestro (MIM) and Velocity AI (Velocity). METHODS: Image registration of pretreatment computed tomography (CT) and posttreatment CT was performed in 24 patients with liver tumors. All the patients received proton beam therapy, and the follow-up period was 4-14 (median: 10) months...
May 4, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28466154/spinal-cord-constraints-in-the-era-of-high-precision-radiotherapy-retrospective-analysis-of-62%C3%A2-spinal-paraspinal-lesions-with-possible-infringements-of-spinal-cord-constraints-within-a%C3%A2-minimal-volume
#17
Sebastian Zschaeck, Peter Wust, Reinhold Graf, Waldemar Wlodarczyk, Reinhard Schild, Alexander Henry Thieme, Mirko Weihrauch, Volker Budach, Pirus Ghadjar
OBJECTIVE: Current constraints aim to minimize the risk of radiation myelitis by the use of restrictive maximal spinal cord doses, commonly 50 Gy. However, several studies suggested that a dose-volume effect could exist. Based on these observations, we evaluated patients receiving potentially excessive doses to the spinal cord within minimal volumes. PATIENTS AND METHODS: Patients receiving radiotherapy between June 2010 and May 2015 using the Novalis(TM) (Varian, Palo Alto, CA, USA; Brainlab, Heimstetten, Germany) radiosurgery system were retrospectively analyzed...
May 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28463159/thermal-skin-damage-during-reirradiation-and-hyperthermia-is-time-temperature-dependent
#18
Akke Bakker, M Willemijn Kolff, Rebecca Holman, Caspar M van Leeuwen, Linda Korshuize-van Straten, Rianne de Kroon-Oldenhof, Coen R N Rasch, Geertjan van Tienhoven, Hans Crezee
PURPOSE: To investigate the relationship of thermal skin damage (TSD) to time-temperature isoeffect levels for patients with breast cancer recurrence treated with reirradiation plus hyperthermia (reRT + HT), and to investigate whether the treatment history of previous treatments (scar tissue) is a risk factor for TSD. METHODS AND MATERIALS: In this observational study, temperature characteristics of hyperthermia sessions were analyzed in 262 patients with recurrent breast cancer treated in the AMC between 2010 and 2014 with reirradiation and weekly hyperthermia for 1 hour...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28457741/commissioning-of-applicator-guided-stereotactic-body-radiation-therapy-boost-with-high-dose-rate-brachytherapy-for-advanced-cervical-cancer-using-radiochromic-film-dosimetry
#19
Saad Aldelaijan, Shada Wadi-Ramahi, Ahmad Nobah, Belal Moftah, Slobodan Devic, Noha Jastaniyah
PURPOSE: To describe an EBT3 GAFCHROMIC film-based dosimetry method to be used in commissioning of a combined HDR brachytherapy (HDRB) and stereotactic body radiation therapy (SBRT) boost for treatment of advanced cervical cancer involving extensive residual disease after external beam treatment. METHODS AND MATERIALS: A cube phantom was designed to firmly fit an intrauterine tandem applicator and EBT3 radiochromic film pieces. A high-risk clinical target volume (CTVHR, Total) was contoured with an extended arm at one side...
April 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28452680/contemporary-radiooncological-management-of-bone-metastases-from-breast-cancer-factors-associated-with-prescription-of-different-fractionation-regimens-short-or-long-course-in-a-rural-part-of-north-norway-with-long-travel-distance
#20
Carsten Nieder, Astrid Dalhaug, Ellinor Haukland, Bård Mannsåker, Adam Pawinski
The aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases from breast cancer. This retrospective study (2007-2014) included 118 Norwegian female patients. All patients received guideline-conform systemic therapy including bone-targeting agents. Median survival was 12...
2017: International Journal of Circumpolar Health
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