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https://www.readbyqxmd.com/read/28749423/distinct-mechanisms-of-biotic-and-chemical-elicitors-enable-additive-elicitation-of-the-anticancer-phytoalexin-glyceollin-i
#1
Kelli Farrell, Md Asraful Jahan, Nik Kovinich
Phytoalexins are metabolites biosynthesized in plants in response to pathogen, environmental, and chemical stresses that often have potent bioactivities, rendering them promising for use as therapeutics or scaffolds for pharmaceutical development. Glyceollin I is an isoflavonoid phytoalexin from soybean that exhibits potent anticancer activities and is not economical to synthesize. Here, we tested a range of source tissues from soybean, in addition to chemical and biotic elicitors, to understand how to enhance the bioproduction of glyceollin I...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28749318/probabilistic-linkage-to-enhance-deterministic-algorithms-and-reduce-data-linkage-errors-in-hospital-administrative-data
#2
Gareth Hagger-Johnson, Katie Harron, Harvey Goldstein, Robert Aldridge, Ruth Gilbert
 BACKGROUND: The pseudonymisation algorithm used to link together episodes of care belonging to the same patients in England (HESID) has never undergone any formal evaluation, to determine the extent of data linkage error. OBJECTIVE: To quantify improvements in linkage accuracy from adding probabilistic linkage to existing deterministic HESID algorithms. METHODS: Inpatient admissions to NHS hospitals in England (Hospital Episode Statistics, HES) over 17 years (1998 to 2015) for a sample of patients (born 13/28th of months in 1992/1998/2005/2012)...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749105/compensation-for-asbestos-related-diseases-in-japan-utilization-of-standard-classifications-of-industry-and-occupations
#3
Kittisak Sawanyawisuth, Sugio Furuya, Eun-Kee Park, Jun-Pyo Myong, Juan Pablo Ramos-Bonilla, Odgerel Chimed Ochir, Ken Takahashi
Background: Asbestos-related diseases (ARD) are occupational hazards with high mortality rates. To identify asbestos exposure by previous occupation is the main issue for ARD compensation for workers. This study aimed to identify risk groups by applying standard classifications of industries and occupations to a national database of compensated ARD victims in Japan. Methods: We identified occupations that carry a risk of asbestos exposure according to the International Standard Industrial Classification of All Economic Activities (ISIC)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749065/concise-review-the-high-cost-of-high-tech-medicine-planning-ahead-for-market-access
#4
REVIEW
Dawn Driscoll, Stephanie Farnia, Panos Kefalas, Richard T Maziarz
Cellular therapies and other regenerative medicines are emerging as potentially transformative additions to modern medicine, but likely at a staggering financial cost. Public health care systems' budgets are already strained by growing and aging populations, and many private insurer's budgets are equally stretched. The current systems that most payers employ to manage their cash flow are not structured to absorb a sudden onslaught of very expensive prescriptions for a large portion of their covered population...
August 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28749051/genomic-justice-and-imagined-communities
#5
Ernesto Schwartz-Marin
In this issue of the Hastings Center Report, Maya Sabatello and Paul Appelbaum explore the assumptions about community embedded in the U.S. Precision Medicine Initiative, which aims to recruit donor-partners who reflect the United States' racial and ethnic diversity. As Sabatello and Appelbaum discuss, the initiative is like other national biobanking efforts in bringing to life an imagined genetic community in need of critical attention, and given the public-private forms of partnership at the heart of the PMI, such efforts could become avenues to deepen existing inequalities rather than to alleviate them...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28749046/pot-economical-total-synthesis-of-estradiol-methyl-ether-through-the-use-of-an-organocatalyst
#6
Yujiro Hayashi, Seitaro Koshino, Kanna Ojima, Eunsang Kwon
Enantioselective total synthesis of estradiol methyl ether has been accomplished in a pot economical manner using five reaction vessels with four purifications. The key reaction is diphenylprolinol silyl ether mediated domino Michael/aldol reaction to afford bicyclo[4.3.0]nonane derivatives with A, C and D rings of steroids as a single isomer with excellent enantioselectivity. Six reactions such as oxidation, hydrogenation, formation of acid chloride, Friedel-Crafts reaction, deprotection and reduction can be carried out in the last one-pot sequence...
July 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28749043/transcriptome-profiling-reveals-the-immune-response-of-goose-t-cells-under-selenium-stimuli
#7
Nan Cao, Wanyan Li, Bingxin Li, Yunbo Tian, Danning Xu
The goose is an economically important poultry species and a principal natural host of avian viruses. This study aimed to determine the effects of selenium on the immune response of geese. Under selenium stimulation, gene expression profiling was investigated using transcriptome sequencing. The selenoproteins were promoted by selenium stimulation, while the heat shock proteins, interleukin and interferons were mainly down-regulated. After comparison, 2228 differentially expressed genes were primarily involved in immune and environmental response, and infectious disease and genetic information processing related pathways were identified...
July 27, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28748762/post-cardiovascular-surgery-atrial-fibrillation-biomarkers-determining-prognosis
#8
Olivia Manfrini, Edina Cenko, Beatrice Ricci, Raffaele Bugiardini
New onset of atrial fibrillation (AF) after cardiovascular surgery is associated with increased risk of complications and length of hospital stay. Identification of patients at high risk of post cardiovascular surgery AF may help to act with preventive strategies having clinical and economic relevance. Many factors such as cardiac remodelling, changes in atrial pressure, surgery trauma, inflammation, oxidative stress, and sympathetic/parasympathetic activation have been implicated in the development of post cardiovascular surgery...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748721/real-world-costs-and-outcomes-in-metastatic-renal-cell-carcinoma-patients-treated-by-targeted-therapies-a-cohort-study-from-the-french-health-insurance-database
#9
Rana Maroun, Laetitia Fleury, Gaelle Nachbaur, Franck Maunoury, Jean-Louis Vanhille, Isabelle Durand-Zaleski
OBJECTIVES: The objective of this study was to describe treatment patterns, survival, healthcare use and costs in patients with metastatic renal cell carcinoma (mRCC) in a real-world setting. RESEARCH DESIGN AND METHODS: We used the National Health Insurance (NHI) claims database for the Ile-de-France region to perform a retrospective cohort analysis of patients with mRCC treated by a first-line targeted therapy. Treatment naïve patients were identified combining the 10(th) revision of the International Classification of Diseases (ICD-10) codes (C64 & C77-C79) and a first prescription of targeted therapies...
July 27, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28748551/identification-of-a-dimeric-kdg-aldolase-from-agrobacterium-tumefaciens
#10
Tatiana P Soares da Costa, Madhvi Patel, Sebastien Desbois, Ruchi Gupta, Pierre Faou, Matthew A Perugini
Agrobacterium tumefaciens is a Gram-negative bacterium and causative agent of Crown Gall disease that infects a variety of economically-important plants. The annotated A. tumefaciens genome contains 10 putative dapA genes, which code for dihydrodipicolinate synthase (DHDPS). However, we have recently demonstrated that only one of these genes (dapA7) encodes a functional DHDPS. The function of the other nine putative dapA genes is yet to be determined. Here, we demonstrate using bioinformatics that the product of the dapA5 gene (DapA5) possesses all the catalytic residues canonical to 2-keto-3-deoxygluconate (KDG) aldolase, which is a class I aldolase involved in glucose metabolism...
July 27, 2017: Proteins
https://www.readbyqxmd.com/read/28748541/reliable-assessment-of-the-incidence-of-childhood-autoimmune-hemolytic-anemia
#11
Nathalie Aladjidi, Marthe-Aline Jutand, Cyrielle Beaubois, Helder Fernandes, Julien Jeanpetit, Gaelle Coureau, Véronique Gilleron, Aude Kostrzewa, Pierre Lauroua, Michel Jeanne, Rodolphe Thiébaut, Thierry Leblanc, Guy Leverger, Yves Perel
BACKGROUND: Childhood autoimmune hemolytic anemia (AIHA) is a rare and severe disease characterized by hemolysis and positive direct antiglobulin test (DAT). Few epidemiologic indicators are available for the pediatric population. The objective of our study was to reliably estimate the number of AIHA cases in the French Aquitaine region and the incidence of AIHA in patients under 18 years old. PROCEDURE: In this retrospective study, the capture-recapture method and log-linear model were used for the period 2000-2008 in the Aquitaine region from the following three data sources for the diagnosis of AIHA: the OBS'CEREVANCE database cohort, positive DAT collected from the regional blood bank database, and the French medico-economic information system...
July 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28748450/replicating-health-economic-models-firm-foundations-or-a-house-of-cards
#12
Inigo Bermejo, Paul Tappenden, Ji-Hee Youn
Health economic evaluation is a framework for the comparative analysis of the incremental health gains and costs associated with competing decision alternatives. The process of developing health economic models is usually complex, financially expensive and time-consuming. For these reasons, model development is sometimes based on previous model-based analyses; this endeavour is usually referred to as model replication. Such model replication activity may involve the comprehensive reproduction of an existing model or 'borrowing' all or part of a previously developed model structure...
July 26, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28748387/costs-of-fragility-hip-fractures-globally-a-systematic-review-and-meta-regression-analysis
#13
REVIEW
S Williamson, F Landeiro, T McConnell, L Fulford-Smith, M K Javaid, A Judge, J Leal
Purpose This study was conducted in order to systematically review the costs of hip fractures globally and identify drivers of differences in costs. Methods A systematic review was conducted to identify studies reporting patient level fragility hip fracture costs between 1990 and 2015. We extracted data on the participants and costs from these studies. Cost data concerning the index hospitalisation were pooled, and a meta-regression was used to examine its potential drivers. We also pooled data on the first-year costs following hip fracture and considered healthcare, social care as well as other cost categories if reported by studies...
July 26, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28748308/smoking-health-related-quality-of-life-and-economic-evaluation
#14
Ángel López-Nicolás, Marta Trapero-Bertran, Celia Muñoz
BACKGROUND AND AIMS: The economic evaluation of tobacco control policies requires the adoption of assumptions about the impact of changes in smoking status on health-related quality of life (HRQoL). Estimates for such impacts are necessary for different populations. This paper aims to test whether smoking status has an independent effect on HRQoL over and above the effect derived from the increased likelihood of suffering a tobacco related disease, and to calculate utility values for the Spanish population...
July 26, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28748176/global-epidemiology-of-dengue-outbreaks-in-1990-2015-a-systematic-review-and-meta-analysis
#15
Congcong Guo, Zixing Zhou, Zihao Wen, Yumei Liu, Chengli Zeng, Di Xiao, Meiling Ou, Yajing Han, Shiqi Huang, Dandan Liu, Xiaohong Ye, Xiaoqian Zou, Jing Wu, Huanyu Wang, Eddy Y Zeng, Chunxia Jing, Guang Yang
Dengue is an arthropod-borne infectious disease caused by dengue virus (DENV) infection and transmitted by Aedes mosquitoes. Approximately 50-100 million people are infected with DENV each year, resulting in a high economic burden on both governments and individuals. Here, we conducted a systematic review and meta-analysis to summarize information regarding the epidemiology, clinical characteristics, and serotype distribution and risk factors for global dengue outbreaks occurring from 1990 to 2015. We searched the PubMed, Embase and Web of Science databases through December 2016 using the term "dengue outbreak...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28748149/the-prognostic-value-of-residual-coronary-stenoses-after-functionally-complete-revascularisation
#16
EDITORIAL
Dennis T L Wong
Fractional flow reserve (FFR) has become the gold standard for functional assessment of coronary artery stenosis. Studies have confirmed the superiority of FFR guided percutaneous coronary intervention (PCI) compared to angiography guided PCI. Due to the high cost of FFR, it is not economically viable for FFR to be incorporated into every routine invasive coronary angiography. As a result, visual estimation of diameter stenosis on invasive coronary angiography still remains the cornerstone for decision making regarding revascularisation treatment for patients...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28748096/unemployment-and-hiv-mortality-in-the-countries-of-the-organisation-for-economic-co-operation-and-development-1981-2009
#17
Mahiben Maruthappu, Charlie Zhou, Callum Williams, Thomas Zeltner, Rifat Atun
OBJECTIVES: To determine an association between unemployment rates and human immunodeficiency virus (HIV) mortality in the Organisation for Economic Co-operation and Development (OECD). DESIGN: Multivariate regression analysis. PARTICIPANTS: OECD member states. SETTING: OECD. MAIN OUTCOME MEASURES: World Health Organization HIV mortality. RESULTS: Between 1981 and 2009, a 1% increase in unemployment was associated with an increase in HIV mortality in the OECD (coefficient for men 0...
July 2017: JRSM Open
https://www.readbyqxmd.com/read/28748079/oxidative-stability-of-chilled-broiler-breast-meat-as-affected-by%C3%A2-dietary-supplementation-with-rosemary-rosmarinus-officinalis-l-powder-and-vitamin-e
#18
Hossein Rostami, Alireza Seidavi, Mohammad Dadashbeiki, Yadollah Asadpour, João Simões, Vito Laudadio, Chrysostomos Milis, Vincenzo Tufarelli
The aim of the present study was to evaluate the effect of rosemary (Rosmarinus officinalis L.) powder and vitamin E, as feed additives combined at different levels, on oxidative stability of broiler meat up to 14th day after chilling. A total of 270 1-day-old male chicks of Ross 308 strain were randomly assigned to nine dietary groups with three replicates having 10 birds each. Diets were supplemented with 0, 0.5, or 1.0% of rosemary (R) powder and 0, 100, or 200 mg/kg of vitamin E (alpha-tocopherol acetate; VitE) according to the following treatments: T1 - control basal diet (0R + 0VitE); T2 - 0R + 100VitE; T3 - 0R + 200VitE; T4 - 0...
July 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28748063/field-application-of-the-micro-biological-survey-method-for-the-assessment-of-the-microbiological-safety-of-different-water-sources-in-horn-of-africa-and-the-evaluation-of-the-effectiveness-of-moringa-oleifera-in-drinking-water-purification
#19
Francesca Losito, Alyexandra Arienzo, Daniela Somma, Lorenza Murgia, Ottavia Stalio, Paolo Zuppi, Elisabetta Rossi, Giovanni Antonini
Water monitoring requires expensive instrumentations and skilled technicians. In developing Countries as Africa, the severe economic restrictions and lack of technology make water safety monitoring approaches applied in developed Countries, still not sustainable. The need to develop new methods that are suitable, affordable, and sustainable in the African context is urgent. The simple, economic and rapid Micro Biological Survey (MBS) method does not require an equipped laboratory nor special instruments and skilled technicians, but it can be very useful for routine water analysis...
June 23, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28748061/host-molecular-factors-and-viral-genotypes-in-the-mother-to-child-hiv-1-transmission-in-sub-saharan-africa
#20
REVIEW
Linda Chapdeleine M Mouafo, Béatrice Dambaya, Nicole N Ngoufack, Céline N Nkenfou
Maternal viral load and immune status, timing and route of delivery, viral subtype, and host genetics are known to influence the transmission, acquisition and disease progression of human immunodeficiency virus-1 (HIV-1) infection. This review summarizes the findings from published works on host molecular factors and virus genotypes affecting mother to child transmission (MTCT) in Africa and identifies the gaps that need to be addressed in future research. Articles in PubMed, Google and AIDSearch and relevant conference abstracts publications were searched...
June 23, 2017: Journal of Public Health in Africa
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