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https://www.readbyqxmd.com/read/28733085/functional-consequences-of-chemically-induced-%C3%AE-arrestin-binding-to-chemokine-receptors-cxcr4-and-ccr5-in-the-absence-of-ligand-stimulation
#1
Marcel Liebick, Sarah Henze, Viola Vogt, Martin Oppermann
Chemokine receptor signaling is a tightly regulated process which was for a long time exclusively attributed to heterotrimeric G proteins. β-Arrestins constitute a separable signaling arm from classical heterotrimeric G proteins, in addition to their well-established roles in receptor desensitization and endocytosis. In order to clearly dissect β-arrestin- from G protein-dependent effects we forced the recruitment of β-arrestin to CXCR4 and CCR5 independently of agonist-promoted receptor activation through chemically-induced dimerization...
July 18, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28731729/surveillance-snapshot-norovirus-outbreaks-among-military-forces-2008-2016
#2
(no author information available yet)
No abstract text is available yet for this article.
July 2017: MSMR
https://www.readbyqxmd.com/read/28731727/incidence-of-gastrointestinal-infections-among-u-s-active-component-service-members-stationed-in-the-u-s-compared-to-u-s-civilians-2012-2014
#3
Sarah E Hill, Daniela E Poss, Stic Harris
Gastrointestinal (GI) infections in the U.S. Armed Forces have consistently been among the most frequent disease and non-battle injury diagnoses. A retrospective analysis of surveillance data categorized as GI infections among active component service members during 2012-2014 was performed. During the study period, 99% of inpatient and outpatient GI encounters were reported as nonspecific GI infection (13,331 cases per 100,000 people), leaving only a small percentage of cases attributed to specific causes. The five most common organisms associated with GI infections were Campylobacter (10...
July 2017: MSMR
https://www.readbyqxmd.com/read/28731726/age-period-cohort-analysis-of-colorectal-cancer-service-members-aged-20-59-years-active-component-u-s-armed-forces-1997-2016
#4
Shauna Stahlman, Alexis Oetting
In the U.S. general population, incidence of colorectal cancer appears to be increasing in younger age groups since the mid-1980s. The objective of this report was to better understand the time-varying elements (age, period, and birth cohort effects) in the epidemiology of colorectal cancer among the active component of the U.S. Armed Forces. During 1997-2016, there were 1,108 incident cases of colorectal cancer among service members aged 20-59 years, corresponding to an overall incidence rate of 4.3 per 100,000 person-years (p-yrs)...
July 2017: MSMR
https://www.readbyqxmd.com/read/28731725/skin-and-soft-tissue-infections-active-component-u-s-armed-forces-2013-2016
#5
Shauna Stahlman, Valerie F Williams, Gi-Taik Oh, Eugene V Millar, Jason W Bennett
During the 4-year surveillance period, there were 282,571 incident cases of skin and soft tissue infection (SSTI) among active component U.S. military members diagnosed in inpatient or outpatient settings, corresponding to an overall incidence of 558.2 per 10,000 person-years (p-yrs). An additional 10,904 cases occurred in theater of operations (460.0 per 10,000 p-yrs). Approximately half (49.4%) were classified as "other SSTI" (e.g., folliculitis, impetigo); 45.9% were cellulitis/abscess; 4.6% were carbuncles/furuncles; and 0...
July 2017: MSMR
https://www.readbyqxmd.com/read/28730946/contribution-of-upper-limb-muscles-to-two-different-gripping-styles-in-elite-indoor-tug-of-war-athletes
#6
Wen-Tzu Tang, Wei-Chih Liao, Hsin-Min Lee
To investigate characteristic upper limb muscle use between two common tug of war (TOW) gripping styles, 20 elite athletes from two high school TOW teams were recruited. Under conditioned attack pulling (with 90% maximal force) on a tug machine, participants used their own habitual gripping style to pull for five 15-s trials. Force and kinematic measurements showed a significantly better force performance and higher centre-of-gravity tilting angle with the gripping style one than with the gripping style two (GS2) (both p < 0...
July 21, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28729058/impacts-of-sensation-perception-and-motor-abilities-of-the-ipsilesional-upper-limb-on-hand-functions-in-unilateral-stroke-quantifications-from-biomechanical-and-functional-perspectives
#7
Hsiu-Yun Hsu, Chia-Wen Ke, Ta-Shen Kuan, Hsiu-Ching Yang, Ching-Liang Tsai, Li-Chieh Kuo
BACKGROUND: The presence of subtle losses in hand dexterity after stroke impacts the regaining of independence with regard to activities of daily living. Therefore, awareness of ipsilesional upper extremity (UE) function may be of importance when drafting a comprehensive rehabilitation program. However, current hand function tests seem to be unable to identify asymptomatic UE impairments. OBJECTIVES: To assess the motor coordination as well as the sensory-perception of an ipsilesional UE using biomechanical analysis of performance-oriented tasks and conducting a Manual Tactile Test (MTT)...
July 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28718329/assessment-of-forearm-rotational-control-using-4-upper-extremity-immobilization-constructs
#8
Ayesha M Rahman, Nicole Montero-Lopez, Richard M Hinds, Michael Gottschalk, Eitan Melamed, John T Capo
BACKGROUND: Forearm immobilization techniques are commonly used to manage distal radius, scaphoid, and metacarpal fractures. The purpose of our study was to compare the degree of rotational immobilization provided by a sugar-tong splint (STS), short arm cast (SAC), Munster cast (MC), and long arm cast (LAC) at the level of the distal radioulnar joint (DRUJ), carpus, and metacarpals. METHODS: Seven cadaveric upper extremity specimens were mounted to a custom jig with the ulnohumeral joint fixated in 90° of flexion...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28717729/middle-eastern-conflicts-implications-for-refugee-health-in-the-european-union-and-middle-eastern-host-countries
#9
Michael Silbermann, Michel Daher, Rejin Kebudi, Omar Nimri, Mazin Al-Jadiry, Lea Baider
Until very recently, health care in conflict settings was based on a model developed in the second half of the twentieth century. Things have changed, and present civil wars, such as those that are currently taking place in the Middle East, do not address the complexity of the ongoing armed conflicts in countries such as Syria, Iraq, and Afghanistan. These conflicts have caused a significant increase in the number of refugees in the region, as well as in Europe. Hundreds of thousands of refugees succeed in settling in mid- and north-European countries, and their health issues are becoming of great importance...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717628/does-combined-strength-training-and-local-vibration-improve-isometric-maximum-force-a-pilot-study
#10
Ruben Goebel, Monoem Haddad, Heinz Kleinöder, Zengyuan Yue, Thomas Heinen, Joachim Mester
BACKGROUND: The aim of the study was to determine whether a combination of strength training (ST) and local vibration (LV) improved the isometric maximum force of arm flexor muscles. ST was applied to the left arm of the subjects; LV was applied to the right arm of the same subjects. The main aim was to examine the effect of LV during a dumbbell biceps curl (Scott Curl) on isometric maximum force of the opposite muscle among the same subjects. It is hypothesized, that the intervention with LV produces a greater gain in isometric force of the arm flexors than ST...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28713744/access-osteotomy-in-the-maxillofacial-skeleton
#11
REVIEW
K Kamalpathey, Maj Gen N K Sahoo, Col P K Chattopadhyay, Maj Yuvraj Issar
Surgical accesses for the facial skeleton are based on the concept of modular osteotomies. Various techniques and combination of osteotomies facilitate access to the most inaccessible tumors of craniomaxillofacial region. Most appropriate surgical access is determined by considering size, location, extension of the tumor, and experience of the surgical team. These are primarily used for tumors in the nasopharynx or the skull base. The aim of this paper is to review surgical accesses that aid in removal of inaccessible tumors of craniomaxillofacial region with series of cases operated in the Department of Oral and Maxillofacial Surgery, Armed Forces Medical College, Pune, India, between July 2008 and June 2010...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713231/grip-force-and-3d-push-pull-force-estimation-based-on-semg-and-grnn
#12
Changcheng Wu, Hong Zeng, Aiguo Song, Baoguo Xu
The estimation of the grip force and the 3D push-pull force (push and pull force in the three dimension space) from the electromyogram (EMG) signal is of great importance in the dexterous control of the EMG prosthetic hand. In this paper, an action force estimation method which is based on the eight channels of the surface EMG (sEMG) and the Generalized Regression Neural Network (GRNN) is proposed to meet the requirements of the force control of the intelligent EMG prosthetic hand. Firstly, the experimental platform, the acquisition of the sEMG, the feature extraction of the sEMG and the construction of GRNN are described...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28711473/interaction-of-reelin-and-stress-on-immobility-in-the-forced-swim-test-but-not-dopamine-mediated-locomotor-hyperactivity-or-prepulse-inhibition-disruption-relevance-to-psychotic-and-mood-disorders
#13
Michael J Notaras, Billie Vivian, Carey Wilson, Maarten van den Buuse
RATIONALE: Psychotic disorders, such as schizophrenia, as well as some mood disorders, such as bipolar disorder, have been suggested to share common biological risk factors. One such factor is reelin, a large extracellular matrix glycoprotein that regulates neuronal migration during development as well as numerous activity-dependent processes in the adult brain. The current study sought to evaluate whether a history of stress exposure interacts with endogenous reelin levels to modify behavioural endophenotypes of relevance to psychotic and mood disorders...
July 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28711419/-barriers-to-treatment-seeking-among-german-veterans-expert-interviews
#14
Stefan Siegel, Heinrich Rau, Simone Dors, Loni Brants, Michaela Börner, Manuel Mahnke, Peter L Zimmermann, Gerd Willmund, Andreas Ströhle
BACKGROUND: The number of service members of the German armed forces suffering from deployment-related mental health problems is increasing. However, less than 50 % seek professional help, and there is little knowledge about barriers to treatment-seeking. METHODS: The article presents data gathered by the Delphi technique combined with focus groups from 55 health service experts regarding the evaluated barriers to treatment-seeking among German veterans. FINDINGS: According to the interviewed experts, major contextual barriers to treatment-seeking include: 1) intimidating processes and structures, 2) actual stigmatization and discrimination, and 3) deficits in supply...
July 12, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28707422/description-of-d-glucosamine-immobilization-kinetics-onto-poly-lactic-acid-surface-via-a-multistep-physicochemical-approach-for-preparation-of-novel-active-biomaterials
#15
Ahmed E Swilem, Marian Lehocký, Petr Humpolíček, Zdenka Kucekova, Igor Novák, Matej Mičušík, Hassan A Abdel-Rehim, El-Sayed A Hegazy, Ashraf A Hamed, Jaroslav Kousal
Poly(lactic acid) (PLA) has shown much success in the preparation of tissue engineering scaffolds as it can be fabricated with a tailored architecture. However, the PLA surface has drawbacks including the lack of biofunctional motifs which are essential for high affinity to biological cells. Therefore, this study describes a multistep physicochemical approach for the immobilization of D-glucosamine (GlcN), a naturally occurring monosaccharide having many biological functions, on the PLA surface aiming at enhancing the cell proliferation activity...
July 13, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28702814/evaluating-the-impact-of-varied-compliance-to-lung-cancer-screening-recommendations-using-a-microsimulation-model
#16
Summer S Han, S Ayca Erdogan, Iakovos Toumazis, Ann Leung, Sylvia K Plevritis
BACKGROUND: The US preventive services task force (USPSTF) recently recommended that individuals aged 55-80 with heavy smoking history be annually screened by low-dose computed tomography (LDCT), thereby extending the stopping age from 74 to 80 compared to the national lung screening trial (NLST) entry criterion. This decision was made partly with model-based analyses from cancer intervention and surveillance modeling network (CISNET), which assumed perfect compliance to screening. METHODS: As part of CISNET, we developed a microsimulation model for lung cancer (LC) screening and calibrated and validated it using data from NLST and the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO), respectively...
July 12, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28701936/an-adaptation-induced-repulsion-illusion-in-tactile-spatial-perception
#17
Lux Li, Arielle Chan, Shah M Iqbal, Daniel Goldreich
Following focal sensory adaptation, the perceived separation between visual stimuli that straddle the adapted region is often exaggerated. For instance, in the tilt aftereffect illusion, adaptation to tilted lines causes subsequently viewed lines with nearby orientations to be perceptually repelled from the adapted orientation. Repulsion illusions in the nonvisual senses have been less studied. Here, we investigated whether adaptation induces a repulsion illusion in tactile spatial perception. In a two-interval forced-choice task, participants compared the perceived separation between two point-stimuli applied on the forearms successively...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28701169/comparison-between-semg-and-force-as-control-interfaces-to-support-planar-arm-movements-in-adults-with-duchenne-a-feasibility-study
#18
Joan Lobo-Prat, Kostas Nizamis, Mariska M H P Janssen, Arvid Q L Keemink, Peter H Veltink, Bart F J M Koopman, Arno H A Stienen
BACKGROUND: Adults with Duchenne muscular dystrophy (DMD) can benefit from devices that actively support their arm function. A critical component of such devices is the control interface as it is responsible for the human-machine interaction. Our previous work indicated that surface electromyography (sEMG) and force-based control with active gravity and joint-stiffness compensation were feasible solutions for the support of elbow movements (one degree of freedom). In this paper, we extend the evaluation of sEMG- and force-based control interfaces to simultaneous and proportional control of planar arm movements (two degrees of freedom)...
July 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28699195/model-based-meta-analysis-on-the-efficacy-of-pharmacological-treatments-for-idiopathic-pulmonary-fibrosis
#19
Phyllis Chan, Leon Bax, Chunlin Chen, Nancy Zhang, Shu-Pang Huang, Holly Soares, Glenn Rosen, Malaz AbuTarif
Recently the FDA approved the first two drugs (pirfenidone and nintedanib) indicated for the treatment of idiopathic pulmonary fibrosis (IPF). The purpose of this analysis was to leverage publicly available data to quantify comparative efficacy of compounds that are approved or in development. An analysis-ready database was developed, and the analysis dataset is composed of summary-level data from 43 arms in 20 trials, with treatment durations ranging from 8 to 104 weeks. A hierarchical multivariable regression model with non-parametric placebo estimation was used to fit the longitudinal profile of change from baseline of percent predicted forced vital capacity (%predicted FVC) data...
July 11, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28694097/behavioural-pharmacology-of-the-%C3%AE-5-gabaa-receptor-antagonist-s44819-enhancement-and-remediation-of-cognitive-performance-in-preclinical-models
#20
István Gacsályi, Krisztina Móricz, Gábor Gigler, János Wellmann, Katalin Nagy, István Ling, József Barkóczy, József Haller, Jeremy J Lambert, Gábor Szénási, Michael Spedding, Ferenc A Antoni
Previous work has shown that S44819 is a novel GABAA receptor (GABAAR) antagonist, which is selective for extrasynaptic GABAARs incorporating the α5 subunit (α5-GABAARs). The present study reports on the preclinical neuropsychopharmacological profile of S44819. Significantly, no sedative or pro-convulsive side effects of S44819 were found at doses up to 30 mg/kg i.p. Object recognition (OR) memory in intact mice was enhanced by S44819 (0.3 mg/kg p.o.) given before the acquisition trial. Mice treated with phencyclidine for two weeks and tested six days after the cessation of treatment failed to show OR memory...
July 8, 2017: Neuropharmacology
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