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https://www.readbyqxmd.com/read/29774220/serum-matrix-metalloproteinase-3-in-detecting-remitting-seronegative-symmetrical-synovitis-with-pitting-edema-syndrome-a-case-report
#1
Tsuneaki Kenzaka, Ken Goda
We report a case of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in a 71-year-old woman. She referred to our hospital with finger stiffness, edema of both hands and feet, pain of bilateral shoulder, wrist, metacarpophalangeal, proximal interphalangeal, and ankle joints. Rheumatoid factor was negative, human leukocyte antigen -B7 antigen was positive. Moreover, matrix metalloproteinase 3 (MMP-3) was high. She was diagnosed with RS3PE syndrome, and treatment with prednisolone (15 mg/d) was started...
May 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29763252/charcot-foot-clinical-clues-diagnostic-strategies-and-treatment-principles
#2
Valerie S Marmolejo, Jonathan F Arnold, Mario Ponticello, Charles A Anderson
Acute Charcot neuroarthropathy of the foot and ankle is often difficult to diagnose because of limited findings in the patient history, physical examination, imaging, and laboratory studies. Delay in treatment results in the development of rigid foot and ankle deformities, increasing the risk of ulceration, infection, and major lower extremity amputation. Acute Charcot neuroarthropathy should be suspected in any patient 40 years or older with obesity and peripheral neuropathy who presents with an acutely swollen foot following minimal or no recalled trauma and who reports minimal to no pain, particularly if radiography and laboratory markers of infection are normal...
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29762056/fracture-of-ankle-mri-using-opposed-phase-imaging-obtained-from-turbo-spin-echo-modified-dixon-image-shows-improved-sensitivity
#3
Jin Hee You, In Hwan Kim, Jinwoo Hwang, Hye Sun Lee, Eun Hae Park
OBJECTIVE: To evaluate if opposed-phase (OP) imaging obtained from the turbo spin echo (TSE) modified Dixon (mDixon) technique can increase the sensitivity of magnetic resonance imaging (MRI) for diagnosing ankle fractures. METHODS: This study included 95 CT-confirmed ankle fractures with additional MRI of the ankle using a TSE modified Dixon technique. Two groups of images were analyzed independently: Group 1 - imaging group without OP imaging; Group 2 - imaging group with OP imaging...
May 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29761026/conservative-management-of-nivolumab-induced-pericardial-effusion-a-case-report-and-review-of-literature
#4
Shagufta Shaheen, Hamid Mirshahidi, Gayathri Nagaraj, Chung-Tsen Hsueh
Background: Nivolumab is an immune checkpoint inhibitor targeting programmed death-1 protein and has been approved for the treatment of multiple advanced malignancies. Adverse effects of immune checkpoint inhibitors are distinct from conventional cytotoxic chemotherapy and can be life-threatening if left unrecognized. Here, we present a case of nivolumab-induced pericardial effusion successfully managed with high-dose corticosteroids. Case presentation: A 70-year-old Caucasian female with a history of 50-pack-year cigarette smoking was diagnosed of recurrent adenocarcinoma of lung after initial surgery...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29743920/electroacupuncture-alleviates-pain-responses-and-inflammation-in-a-rat-model-of-acute-gout-arthritis
#5
Wenxin Chai, Yan Tai, Xiaomei Shao, Yi Liang, Guo-Qing Zheng, Ping Wang, Jianqiao Fang, Boyi Liu
Acute gout arthritis is one of the most painful inflammatory conditions. Treatments for gout pain are limited to colchicine, nonsteroidal anti-inflammatory drugs, and corticosteroids, which oftentimes result in severe adverse effects. Electroacupuncture (EA) has been proved to be effective in relieving many inflammatory pain conditions with few side effects. Here, we aim to investigate the therapeutic potentials of EA on pain and inflammation of a rat model of acute gout arthritis and underlying mechanisms...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29709007/chikungunya-virus-infection-in-aruba-diagnosis-clinical-features-and-predictors-of-post-chikungunya-chronic-polyarthralgia
#6
Ralph Huits, Jaclyn De Kort, Riemsdijk Van Den Berg, Luis Chong, Achilleas Tsoumanis, Kaat Eggermont, Koen Bartholomeeusen, Kevin K Ariën, Jan Jacobs, Marjan Van Esbroeck, Emmanuel Bottieau, Lieselotte Cnops
BACKGROUND: Chikungunya virus (CHIKV) emerged in Aruba for the first time in 2014. We studied the clinical presentation of acute CHIKV infection and the contribution of serologic and molecular assays to its diagnosis. In a cohort of confirmed CHIKV cases, we analysed the frequency, duration and predictors of post-chikungunya chronic polyarthralgia (pCHIK-CPA), defined as joint pains lasting longer than 6 weeks or longer than 1 year. METHODOLOGY: Patient sera obtained within 10 days of symptom onset were tested for CHIKV, using an indirect immunofluorescence test for the detection of CHIKV-specific Immunoglobulin M (IgM) and post-hoc, by reverse-transcription polymerase chain reaction (RT-PCR)...
2018: PloS One
https://www.readbyqxmd.com/read/29687409/a-1470-nm-laser-combined-with-foam-sclerotherapy-in-day-surgery-a-better-choice-for-lower-limb-varicose-veins
#7
Xing Zhang, Xin Wang, Cheng Gao, Jinbao Qin, Haiguang Zhao, Weimin Li, Xinwu Lu
Day surgery is being more and more adopted by clinicians. Higher wavelength lasers give patients better experience than lower wavelength lasers, which makes it more suitable for day surgery. This study compares the short- and mid-term efficacy, postoperative morbidity, and patient satisfaction of "1470-nm endovenous laser ablation (EVLA) combining foam sclerotherapy in day surgery" with "810-nm EVLA with high ligation combining foam sclerotherapy in hospital surgery" on great saphenous vein (GSV) insufficiency postoperatively...
April 23, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29670797/recurrent-migratory-transient-bone-marrow-edema-of-the-knees-associated-with-low-vitamin-d-and-systemic-low-bone-mineral-density-a-case-report-and-literature-review
#8
Omar Alsaed, Mohammad Hammoudeh
Transient bone marrow edema (TBME) is a self-limiting disease characterized by joint pain with localized bone marrow edema by MRI and has been reported in many case series and case reports. It is well known that joints of the lower extremity including hips, knees, ankles, and feet are the classical sites for TBME. Many theories have been proposed for the pathogenesis of TBME. Systemic osteopenia and vitamin D deficiency is one of the theories that have been suggested in the last few years. In this case report, we present a middle-aged male patient, who presented with 4 attacks of TBME in both knees between September 2016 and August 2017...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29657213/reactive-perforating-collagenosis-an-important-differential-diagnosis-in-hemodialysis-patients
#9
Ayan Kumar Dey
This is a case report of a 68-year-old hypertensive, diabetic woman who was on regular thrice weekly hemodialysis (HD). She presented with gradually worsening left lower limb pain and swelling. Clinical examination revealed significant edema over the left calf and ankle joint with significant calf tenderness. Extensive workup including magnetic resonance imaging of the lower limb and venous Doppler failed to show any significant abnormality. In view of developing papular lesions over the area, skin biopsy was performed, which finally confirmed reactive perforating collagenosis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29597050/did-fr%C3%A3-d%C3%A3-ric-chopin-die-from-heart-failure
#10
Antonio Perciaccante, Philippe Charlier, Camilla Negri, Alessia Coralli, Otto Appenzeller, Raffaella Bianucci
On October 17, 1849, Poland's greatest composer, Frédéric Chopin (1810-1849) died aged 39. His cause of death remains unknown. An investigation of the documental sources was performed to reconstruct the medical history of the artist. Since his earliest years, his life had been dominated by poor health. Recurrent episodes of cough, fever, headaches, lymphadenopathy- a series of symptoms that may be attributed to viral respiratory infections- manifested in his teens. Later in life, he had chest pain, hemoptysis, hematemesis, neuralgia, and arthralgia...
May 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29587801/effects-of-dangguixu-san-on-acute-lateral-ankle-sprain-study-protocol-for-a-randomized-controlled-trial
#11
Jae-Hong Kim, Eun-Yong Lee, Myung-Rae Cho, Cham-Kyul Lee, Ji-Hyun Cho
BACKGROUND: Ankle sprain is a common musculoskeletal injury. In Korean medicine, blood stasis is thought to be the main cause of pain and swelling in patients with ankle sprain. Dangguixu-san (DS), a herbal extract, is widely used in Korean medicine for the treatment of traumatic ecchymosis and pain by promoting blood circulation and relieving blood stasis. However, the effects of DS on ankle sprain have not been evaluated in a randomized clinical trial. Here, we describe the protocol for a randomized controlled trial that will evaluate the efficacy and safety of DS for the treatment of ankle sprain...
March 27, 2018: Trials
https://www.readbyqxmd.com/read/29575818/collagen-induced-arthritis-as-an-animal-model-of-rheumatoid-cachexia
#12
Paulo V G Alabarse, Priscila S Lora, Jordana M S Silva, Rafaela C E Santo, Eduarda C Freitas, Mayara S de Oliveira, Andrelise S Almeida, Mônica Immig, Vivian O N Teixeira, Lidiane I Filippin, Ricardo M Xavier
BACKGROUND: Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia-without loss of fat mass and body weight-for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia...
March 25, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29560002/a-rare-case-of-eosinophilic-granulomatosis-with-polyangiitis-associated-with-cryoglobulinemia-presenting-with-a-bullous-skin-eruption-of-the-lower-limbs
#13
D D K Abeyaratne, C Liyanapathirana, C L Fonseka, P W M C S B Wijekoon
Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is an antineutrophil cytoplasmic antibody- (ANCA-) associated small vessel vasculitis with multisystem involvement. It is characterized with asthma, eosinophilia, and renal and peripheral nervous system involvement. However, EGPA presenting with bullous skin eruption is an uncommon dermatological manifestation. We report a rare case of EGPA overlapped with mixed essential cryoglobulinemia presenting with a bullous skin eruption...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29512362/long-haul-flights-edema-and-thrombotic-events-prevention-with-stockings-and-pycnogenol%C3%A2-supplementation-lonflit-registry-study
#14
Gianni Belcaro, Umberto Cornelli, Mark Dugall, Morio Hosoi, Roberto Cotellese, Beatrice Feragalli
BACKGROUND: This registry study evaluated the effects of Pycnogenol® on edema and thrombotic complications in long-haul flights; jet lag was also evaluated. METHODS: Four hundred and fifty subjects at different risk levels for thrombosis, flying in economy class twice a week for more than 8 hours, were included; 295 completed the registry study and were subdivided in 3 groups according to their risk level - low, moderate, or high. The high-risk group also received Aspirin®...
April 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29503136/foot-and-ankle-osteoid-osteomas
#15
Volkan Gurkan, Ozgur Erdogan
Foot and ankle osteoid osteomas (OOs) are often cancellous or subperiosteal and rarely present with a periosteal reaction. Additionally, the large number of disorders included in the differential diagnosis and the nonspecific findings on radiographs complicate the diagnosis. We performed a manual search of the senior surgeon's hospitals' operating room records for the terms "benign bone tumor," "foot," "ankle," and "osteoid osteoma" from January 2003 until December 2014...
March 2, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29487249/predictors-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-patients-with-chronic-obstructive-pulmonary-disease-from-a-tertiary-care-center-in-india
#16
Irfan Ismail Ayub, Abdul Majeed Arshad, Prathipa Sekar, Natraj Manimaran, Dhanasekar Thangaswamy, Chandrasekar Chockalingam
Background: There is dearth of literature on asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) in India. The aim was to compare clinical characteristics between patients with ACOS and non-ACOS COPD and to identify clinical predictors of ACOS in patients with COPD. Methods: We conducted a retrospective study by reviewing data collected from patients performing spirometry at our hospital. Those with postbronchodilator FEV1 /FVC <70% were included in the study...
March 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29486726/concurrent-methicillin-resistant-staphylococcus-aureus-septicemia-and-pyomyositis-in-a-patient-with-dengue-hemorrhagic-fever-a-case-report
#17
N D B Ehelepola, R K G M Rajapaksha, D M U B Dhanapala, T D K Thennekoon, S Ponnamperuma
BACKGROUND: Concurrent presence of dengue hemorrhagic fever (DHF), tropical pyomyositis and septicemia due to methicillin-resistant Staphylococcus aureus (MRSA) in a previously healthy person has never been reported. These three conditions even individually are potentially fatal. "Here we describe a case of a patient contracting dengue and developing DHF along with concurrent pyomyositis likely to be due to MRSA, leading to MRSA septicemia with abscesses formed by MRSA". CASE PRESENTATION: A 44-year old previously healthy Sinhalese man presented on day 3 of the illness with fever, headache, arthralgia and myalgia and watery loose stools...
February 27, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29484236/efficacy-of-the-stretch-band-ankle-traction-technique-in-the-treatment-of-pediatric-patients-with-acute-ankle-sprains-a-randomized-control-trial
#18
Kathryn Iammarino, James Marrie, Mitchell Selhorst, Linda P Lowes
Background: Ankle injuries account for up to 40% of all sport related injuries. These injuries can result in weeks to months of missed sport or work. The PRICE (Protection, Rest, Ice, Compression, Elevation) treatment is standard care for most acute ankle sprains. Recently, early mobilization in adults has been shown to decrease time off from sport or work, and the likelihood of developing chronic instability. To date, no research has been performed assessing the effectiveness of early mobilization in pediatric patients (<18 years)...
February 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29476376/regenerative-treatment-of-osteochondral-lesions-of-distal-tibial-plafond
#19
Matteo Baldassarri, Luca Perazzo, Marco Ricciarelli, Simone Natali, Francesca Vannini, Roberto Buda
OBJECTIVES: Osteochondral lesions of the distal tibial plafond (OLTP) are rare and far less common than osteochondral lesions of the talus. Literature data do not report clinical records with significant number of cases and follow-up. The aim of our study was to evaluate clinical and MRI outcomes following arthroscopic treatment of distal tibia osteochondral lesions and to report our results with treating these rare lesions. METHODS: Between October 2010 and November 2011, a consecutive series of 27 patients, 15 males and 12 females, were treated arthroscopically with the one-step BMDCT for OLTPs...
February 23, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29472747/lercanidipine-in-the-management-of-hypertension-an-update
#20
REVIEW
Guido Grassi, Nicolàs R Robles, Gino Seravalle, Francesco Fici
Calcium channel blockers (CCBs), particularly dihydropyridine-CCBs, (DHP-CCBs), have an established role in antihypertensive therapy, either as monotherapy or in combination with other antihypertensive drugs. Two hundred and fifty-one papers published in PubMed in English between January 1, 1990, and October 31, 2016, were identified using the keyword "lercanidipine." Lercanidipine is a lipophilic third-generation DHP-CCB, characterized by high vascular selectivity and persistence in the smooth muscle cell membranes...
October 2017: Journal of Pharmacology & Pharmacotherapeutics
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