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https://www.readbyqxmd.com/read/29344052/manidipine-an-antihypertensive-drug-with-positive-effects-on-metabolic-parameters-and-adrenergic-tone-in-patients-with-diabetes
#1
REVIEW
Margarita SaizSatjes, Francisco Javier Martinez-Martin
Antihypertensive treatment of patients with diabetes should include those drugs with a positive effect on metabolic parameters. Most patients with diabetes require at least two antihypertensive agents. Combining a dihydropyridine calcium channel blocker with a renin-angiotensin-aldosterone system inhibitor is a rational approach. However, not all dihydropyridines are equal with respect to their effects on metabolic parameters. Thus, manidipine exerts a positive effect on insulin resistance. However, this effect has not been observed with amlodipine...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29305041/arthroscopic-treatment-of-osteochondral-lesions-of-the-talus-using-juvenile-articular-cartilage-allograft-and-autologous-bone-marrow-aspirate-concentration
#2
Bridget A DeSandis, Amgad M Haleem, Carolyn M Sofka, Martin J O'Malley, Mark C Drakos
Juvenile allogenic chondrocyte implantation (JACI; DeNovo NT Natural Tissue Graft®; Zimmer, Warsaw, IN) with autologous bone marrow aspirate concentrate (BMAC) is a relatively new all-arthroscopic procedure for treating critical-size osteochondral lesions (OCLs) of the talus. Few studies have investigated the clinical and radiographic outcomes of this procedure. We collected the clinical and radiographic outcomes of patients who had undergone JACI-BMAC for talar OCLs to assess treatment efficacy and cartilage repair tissue quality using magnetic resonance imaging (MRI)...
January 2, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29244676/severe-metal-hypersensitivity-following-internal-fixation-of-an-ankle-fracture-a-case-report
#3
Bradley M Kruckeberg, Taylor J Ridley, Lee M Reichel
CASE: A 67-year-old woman underwent internal fixation of an ankle fracture. Ten days postoperatively, the patient developed systemic hives, difficulty breathing, and oral swelling. At 8 weeks postoperatively, the hardware was removed because of a suspected metal hypersensitivity. Despite experiencing perioral edema and difficulty breathing after the hardware removal, she had complete resolution of the symptoms at the 2-week, 6-week, and 12-month follow-up appointments. CONCLUSION: Hypersensitivities to metal-based implants can develop and cause local and systemic reactions...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29237099/calcium-channel-blockers-for-primary-and-secondary-raynaud-s-phenomenon
#4
REVIEW
Fadumo Rirash, Paul C Tingey, Sarah E Harding, Lara J Maxwell, Elizabeth Tanjong Ghogomu, George A Wells, Peter Tugwell, Janet Pope
BACKGROUND: Raynaud's phenomenon is a vasospastic disease characterized by digital pallor, cyanosis, and extremity pain. Primary Raynaud's phenomenon is not associated with underlying disease, but secondary Raynaud's phenomenon is associated with connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease. Calcium channel blockers promote vasodilation and are commonly used when drug treatment for Raynaud's phenomenon is required...
December 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29230289/accessory-anterolateral-talar-facet-impingement-with-tibialis-spastic-varus-foot
#5
Toshinori Kurashige
In recent years, some authors have reported accessory anterolateral talar facet impingement with flatfoot including peroneal spastic flatfoot. Conversely, to our knowledge, no case report has been published about accessory anterolateral talar facet impingement with tibialis spastic varus foot. We report the first case in a 22-year-old man with intellectual disability, bilateral cleft hands and type 1 diabetes mellitus. Since spraining his left ankle over a year earlier, he experienced left sinus tarsi pain while standing and walking...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29219020/correlation-of-mri-appearance-of-autologous-chondrocyte-implantation-in-the-ankle-with-clinical-outcome
#6
Keith W Chan, Richard D Ferkel, Brian Kern, Sarah S Chan, Gregory R Applegate
The objective of this study was to characterize magnetic resonance imaging (MRI) findings and correlate with clinical results in patients who underwent autologous chondrocyte implantation (ACI) of osteochondral lesions of the talus (OLT). METHODS: Twenty-four grafts were evaluated at a mean 65.8 months after ACI for OLT. MRI was performed on a 1.5-T GE scanner using multiple sequences. Graft appearance was compared with preoperative MRI and evaluated for 6 criteria: defect fill, surface regularity, signal pattern, bone marrow edema, subchondral plate irregularity, and presence of cystic lesions...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29192804/hecogenin-exhibits-anti-arthritic-activity-in-rats-through-suppression-of-pro-inflammatory-cytokines-in-complete-freund-s-adjuvant-induced-arthritis
#7
Deepa K Ingawale, Snehal S Patel
Hecogenin is a steroidal sapogenin isolated from the leaves of Agave genus species that plays an important role in the treatment of a variety of inflammatory diseases. The aim of the present study was to evaluate the anti-arthritic activity of hecogenin in Complete Freund's adjuvant-induced arthritis in rats. The hecogenin (40 µl of 50 µg/kg, orally) and hecogenin + fluticasone (40 µl of 25 µg/kg, each, orally) was tested against Complete Freund's adjuvant-induced arthritis in rats by evaluating various parameters such as paw volume, arthritic score, joint diameter, spleen weight, thymus weight, haematological and biochemical parameters and pro-inflammatory cytokines...
December 1, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29184288/a-new-model-of-skeletal-muscle-atrophy-induced-by-immobilization-using-a-hook-and-loop-fastener-in-mice
#8
Masahiro Aihara, Noboru Hirose, Wakana Katsuta, Fumiaki Saito, Hitoshi Maruyama, Hiroki Hagiwara
[Purpose] To study muscle atrophy, the muscle atrophy model mice have been used frequently. In particular, cast immobilization is the most common method to induce muscle atrophy. However, it is time consuming and often causes adverse events including skin injury, edema, and necrosis. The present study, we developed a hook-and-loop fastener (Velcro) immobilization method as a new, simple, and less invasive approach to induce muscle atrophy. [Subjects and Methods] Mice were bandaged in the knee joint extension and ankle plantar extension position...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29181207/mycoplasma-pneumonia-an-unrecognized-cause-of-fever-of-unknown-origin-in-an-adult
#9
Fatima Ali-Ahmed, Alexandra Halalau
A 26-year-old female was admitted for fever of unknown origin (FUO), headaches, left ankle edema, and a lower extremity rash consistent with erythema nodosum. She had no respiratory symptoms or family history of autoimmune diseases. A chest X-ray was negative for pneumonia or hilar adenopathy. Extensive autoimmune workup was negative. A chest, abdomen, and pelvis computed tomography scan was unremarkable and laboratory studies revealed no source of infection. On hospital day 5, the patient developed a mild productive cough...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29144772/subchondral-bone-degradation-after-microfracture-for-osteochondral-lesions-of-the-talus-an-mri-analysis
#10
Yoshiharu Shimozono, Max Coale, Youichi Yasui, Amanda O'Halloran, Timothy W Deyer, John G Kennedy
BACKGROUND: Microfracture is the most common cartilage-reparative procedure for the treatment of osteochondral lesions of the talus (OLTs). Damage to the subchondral bone (SCB) during microfracture may irreversibly change the joint-loading support of the ankle, leading to reparative fibrocartilage degradation over time. PURPOSE: To investigate the morphological change in the SCB after microfracture for OLT by developing a novel magnetic resonance imaging (MRI) scoring system specifically for evaluating the SCB...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29142816/unilateral-pulmonary-edema-in-a-patient-with-worsening-tricuspid-valve-regurgitation-a-secret-inside-pulmonary-veins
#11
Elvira Resciniti, Ilaria Caso, Iside Scarfò, Giuseppe Di Pasquale, Giovanni La Canna
We present the case of a 69-year-old patient who was referred to the Department of Echocardiography for surgical treatment of severe tricuspid valve regurgitation (TVR) with advanced congestive heart failure. In 2013 the patient underwent unsuccessful percutaneous ablation for permanent atrial fibrillation. In 2015, following numerous episodes of atrial fibrillation and congestive heart failure with left pleural effusion, the patient was admitted to another center. A transthoracic echocardiogram showed severe TVR and moderate precapillary pulmonary hypertension, confirmed at right cardiac catheterization...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29126038/magnetic-resonance-imaging-findings-of-chronic-plantar-fasciitis-before-and-after-extracorporeal-shock-wave-therapy
#12
Masahiro Maki, Kazuya Ikoma, Masamitsu Kido, Yusuke Hara, Koshiro Sawada, Suzuyo Ohashi, Toshikazu Kubo
INTRODUCTION: The objective of this study is to examine the relationships between treatment outcome and changes in magnetic resonance (MR) imaging findings after extracorporeal shock wave therapy (ESWT) for chronic plantar fasciitis. METHODS: The subjects were 23 feet of 23 patients of refractory plantar fasciitis. The mean age was 53.7 years. The thickness of the plantar fascia (PF) and findings of a high-signal intensity area (HSIA) inside the PF, edema around the PF, and bone marrow edema (BME) of the calcaneus were investigated on MR images...
December 2017: Foot
https://www.readbyqxmd.com/read/28989069/the-role-of-biomarkers-in-dilated-cardiomyopathy-assessment-of-clinical-severity-and-reverse-remodeling
#13
Sandra Amorim, Manuel Campelo, Brenda Moura, Elisabete Martins, João Rodrigues, Isaac Barroso, Margarida Faria, Tiago Guimarães, Filipe Macedo, José Silva-Cardoso, Maria Júlia Maciel
INTRODUCTION: Biomarkers in dilated cardiomyopathy (DCM) reflect various pathobiological processes, including neurohormonal activation, oxidative stress, matrix remodeling, myocyte injury and myocyte stretch. We assessed the role of biomarkers in clinical and echocardiographic parameters and in left ventricular (LV) reverse remodeling (LVRR). METHODS: In this prospective study of 50 DCM patients (28 men, aged 59±10 years) with LV ejection fraction (LVEF) <40%, LVRR was defined as an increase of >10 U in LVEF after optimal medical therapy...
October 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28987656/meta-analysis-of-dual-energy-computed-tomography-virtual-non-calcium-imaging-to-detect-bone-marrow-edema
#14
Mou Li, Yali Qu, Bin Song
OBJECTIVE: This meta-analysis aimed to evaluate the accuracy of dual-energy CT (DECT) virtual non-calcium (VNC) imaging for the detection of bone marrow edema (BME). METHODS: A systematic literature search up to March 2017 was performed to find relevant original studies. Two reviewers independently selected studies, assessed literature quality, and extracted data. Pooled sensitivity, specificity, area under receiver operating characteristic (AUROC) curve, and other measures of DECT accuracy for detecting BME were calculated using random effects models...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28979581/anterior-incision-offloading-for-primary-and-revision-total-ankle-replacement-a-comparative-analysis-of-two-techniques
#15
Andrew D Elliott, Thomas S Roukis
BACKGROUND: There exists a high risk of post-operative complications with primary and revision total ankle replacement surgery. Delayed wound healing of the anterior incision is common. The reason for this is multi-factorial and, to date, most of the research has focused on predisposing factors involving the patients themselves. Only recently have researchers begun to look at the post-operative dressing as a possible consideration when trying to prevent incision wound healing complications...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28945059/tissue-dielectric-constant-and-circumference-measurement-in-the-follow-up-of-treatment-related-changes-in-lower-limb-lymphedema
#16
Alper Tugral, Tuomas Viren, Yesim Bakar
BACKGROUND: Lymphedema of lower limbs is a chronic condition that requires life-long management. Therapeutic effect of Complex Decongestive Physiotherapy (CDP) is most often followed by circumference measurements (CM). However, the CM measurements are not specific to interstitial tissue fluid and have problems in sensitivity and objectivity. The aim of present study was to evaluate the therapeutic effect of CDP with a new tissue water specific measurement technique, in patients with lower limb lymphedema (LLL)...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28926599/experimental-colitis-delays-and-reduces-the-severity-of-collagen-induced-arthritis-in-mice
#17
Julie Hablot, Laurent Peyrin-Biroulet, Tunay Kokten, Reine El Omar, Patrick Netter, Claire Bastien, Jean-Yves Jouzeau, Harry Sokol, David Moulin
Amongst extraintestinal manifestations (EIM) occurring in IBD patients, rheumatologic manifestations are the most frequent. Understanding the relationships between arthritis and colitis is a prerequisite to improving the management of these patients. Microbiota of patients with IBD or rheumatologic diseases, like spondyloarthritis (SpA) is modified compared to healthy individual. Thus, we have evaluated the impact of colitis in the development of arthritis in mice and we have analyzed microbiota changes. Collagen-induced arthritis (CIA) was induced at day 0 in DBA1 mice exposed or not to Dextran Sodium Sulfate (DSS) to induce colitis between day 14 and day 21...
2017: PloS One
https://www.readbyqxmd.com/read/28780841/-mri-anatomy-and-injury-of-the-lateral-collateral-ligaments-of-ankle
#18
Z H Qian, Y Liu, R J Bai, H L Zhan, H Zhang, Y X Li, B D Wu
Objective: To explore the MRI features of the lateral collateral ligament injuries of the ankle and determine the value MRI in diagnosing the ligament injuries of the ankle. Methods: The study was reviewed and approved by an institutional review board of hospital. Retrospective analysised 10 healthy volunteers and 26 ankle injury cases underwent surgery since January 2013 to September 2016, the MR imaging findings of patients were compared with volunteers' and operative documents, to analysis the MRI feature of the ligament injuries of the ankle...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28777906/can-amputation-be-prevented-in-diabetic-foot-interdisciplinary-approach-to-diabetic-foot-a-case-report
#19
Ali Erdal Gunes, Maide Cimsit
Diabetic foot ulcers may result in loss of an extremity and may even lead to mortality. The use of comprehensive foot care programs which include early screening and evaluation of problems, foot care education, preventive therapy and referral to specialists has been shown to reduce amputation rates by 49-85 [percent]. A 51-year-old woman with Type 2 diabetes under surveillance for nine months was referred from the emergency department. She presented with an entirely inflamed right foot with ulcer covering two-thirds proximal of the foot for 30 days' duration...
March 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28754008/combination-therapy-of-peg-hm-3-and-methotrexate-retards-adjuvant-induced-arthritis
#20
Jingchao Hao, Xiaodong Wu, Sarra Setrerrahmane, Kun Qian, Yueying Hou, Liting Yu, Chenyu Lin, Qianqian Wu, Hanmei Xu
At present, the early phenomenon of inflammatory angiogenesis is rarely studied in Rheumatoid arthritis (RA). Previous research found that PEG-HM-3, an integrin inhibitor, possessed anti-angiogenesis and anti-rheumatic activity. In this study, the advantages of inhibiting angiogenesis and immune cell adhesion and migration, as well as the benefits of anti-arthritis effects, were evaluated using a combination of PEG-HM-3 and methotrexate (MTX). In vitro, spleen cell proliferation and the levels of tumor necrosis factor α (TNF-α) in macrophage supernatant were assessed...
July 21, 2017: International Journal of Molecular Sciences
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