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https://www.readbyqxmd.com/read/28699722/antinociceptive-anti-inflammatory-and-antiarthritic-activities-of-bungarus-fasciatus-venom-in-experimental-animal-models
#1
Susmita Ghosh, Partha Pratim Saha, Subir C Dasgupta, Antony Gomes
Pain and inflammation are intimately associated with rheumatoid arthritis, a growing bone-joint related problem of the modern society. Though several therapeutic managements are available for arthritis, their side effects not only limit their use, but also advocate the quest for natural therapies. In this study, we explored the antinociceptive, anti-inflammatory and antiarthritic activities of Bungarus fasciatus venom (BFV) in experimental animal models. Rheumatoid arthritis was induced by Freund’s complete adjuvant (FCA) in male Wistar albino rats...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28682141/response-to-letter-regarding-high-prevalence-of-vitamin-d-deficiency-in-patients-with-bone-marrow-edema-syndrome-of-the-foot-and-ankle
#2
Konstantin Horas
No abstract text is available yet for this article.
July 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28676830/nyctanthes-arbor-tristis-ameliorated-fca-induced-experimental-arthritis-a-comparative-study-among-different-extracts
#3
Maliha Uroos, Zaigham Abbas, Shumaila Sattar, Nigarish Umer, Arham Shabbir, Shafiq-Ur-Rehman, Ahsan Sharif
Nyctanthes arbor-tristis (NAT) is commonly used traditionally for the treatment of rheumatism and inflammatory diseases. Current study evaluates the antiarthritic potential of NAT using Freund's adjuvant-induced arthritic rat model. Treatments with methanolic, ethyl acetate, and n-hexane extracts were continued for consecutive 20 days. Macroscopic arthritic scoring and water displacement plethysmometry were used to evaluate arthritic development. Hematological and biochemical parameters were investigated and ankle joints were processed for histopathological evaluation...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28667873/new-arylpyrazoline-coumarins-synthesis-and-anti-inflammatory-activity
#4
Liu Zeng Chen, Wei Wei Sun, Li Bo, Jie Quan Wang, Cheng Xiu, Wen Jian Tang, Jing Bo Shi, Hai Pin Zhou, Xin Hua Liu
To develop new anti-inflammatory agents with improved pharmaceutical profiles, a series of new phenyl-pyrazoline-coumarin derivatives (4a∼4m) were designed and synthesized. Compounds 4a and 4b were determined by X-ray crystallography. All of the compounds have been screened for their anti-inflammatory activity characterized by evaluating their inhibition against LPS-induced IL-6 release. Among them, compound 4m showed the highest anti-inflammatory activity with inhibiting IL-6, TNF-α and nitric oxide (NO) production lipopolysaccharide (LPS)-stimulated...
June 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28664488/radiologic-findings-for-prediction-of-rehabilitation-outcomes-in-patients-with-chronic-symptomatic-os-subfibulare
#5
Beom Suk Kim, Sungmin Woo, Jae Young Kim, Chankue Park
OBJECTIVE: To retrospectively evaluate the radiologic findings for predicting rehabilitation outcomes in patients with chronic symptomatic os subfibulare. MATERIALS AND METHODS: 38 patients with chronic lateral ankle pain and os subfibulare underwent a standardized rehabilitation program. Rehabilitation outcome was evaluated after ≥3 months of intervention as the following: good response group (n = 20) without the need for further treatment and poor response group (n = 18) who underwent surgery after rehabilitation...
June 29, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28634696/prominent-midfoot-involvement-in-children-with-enthesitis-related-arthritis-category-of-juvenile-idiopathic-arthritis
#6
Sanat Phatak, Namita Mohindra, Abhishek Zanwar, Amita Aggarwal
Foot involvement is common in juvenile idiopathic arthritis (JIA) but is often unrecognized and difficult to treat. This study was done to assess clinical and radiological involvement of the feet and its impact on function in Indian children with enthesitis-related arthritis (ERA). We enrolled consecutive children with ERA with disease duration of less than 5 years. All patients underwent clinical examination of the feet and filled the juvenile arthritis foot index (JAFI) questionnaire. Ultrasound (US) of foot joints and entheses and extremity magnetic resonance imaging (MRI) scan of one foot were done...
August 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28632507/tibialis-posterior-tenosynovitis-a-unique-musculoskeletal-manifestation-of-gout
#7
Peter Shupper, Todd P Stitik
Extra-articular manifestations of gout can present in several ways, including tenosynovitis. We present a rare case of acute tibialis posterior gouty tenosynovitis. An 82-year-old man with a history of well-controlled gout presented with acute onset of left ankle pain, occurring without inciting event. The medial ankle was slightly erythematous with moderate dorsal-medial swelling and mild dorsal-lateral swelling, with severe tenderness to palpation over the medial retro-malleolar region. Range of motion and manual muscle testing were pain limited throughout...
June 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28624992/compression-therapy-after-ankle-fracture-surgery-a-systematic-review
#8
REVIEW
R Winge, L Bayer, H Gottlieb, C Ryge
PURPOSE: The main purpose of this systematic review was to investigate the effect of compression treatment on the perioperative course of ankle fractures and describe its effect on edema, pain, ankle joint mobility, wound healing complication, length of stay (LOS) and time to surgery (TTS). The aim was to suggest a recommendation to clinicians considering implementing compression therapy in the standard care of the ankle fracture patient, based on the existing literature. METHODS: We conducted a systematic search of literature including studies concerning adult patients with unstable ankle fractures undergoing surgery, testing either intermittent pneumatic compression, compression bandage and/or compression stocking and reporting its effect on edema, pain, ankle joint mobility, wound healing complication, LOS and TTS...
June 17, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28603855/stress-fractures-of-the-calcaneus-diagnosed-by-sonography-report-of-8-cases
#9
Stefano Bianchi, Dien Hung Luong
We present a retrospective review of 8 patients (6 women and 2 men, with an age range of 46-80 years; mean age, 60.2 years) in whom sonography was used to diagnose a calcaneal stress fracture. Sonography was performed because of a clinical suspicion of soft tissue injuries. Two patients were first assessed by standard radiography; for the remaining patients, sonography was the first imaging technique used. Patients were subsequently examined by magnetic resonance imaging, except for 1 patient in whom the diagnosis was made only on a clinical-sonographic correlation...
June 12, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28551052/fresh-osteochondral-allotransplants-outcomes-failures-and-future-developments
#10
M Tschon, F Veronesi, S Giannini, M Fini
Osteochondral allografts are used to treat many different conditions as acute traumatic large-sized lesions, degenerative osteoarthritis, osteochondritis dissecans, avascular necrosis or in case of failure of previous procedures particularly in young patients for whom primary prosthesis is not desirable. Fresh allografts present the advantage of having mature viable hyaline cartilage, not causing donor morbidity, allowing the restoration of even large defects in a single surgical session. Conversely, they could account for risks of disease transmission, immunologic reactions, and for limited availability...
May 11, 2017: Injury
https://www.readbyqxmd.com/read/28533627/reduced-foot-pain-after-spasticity-control-with-alcohol-block-in-a-patient-with-chronic-hemiparetic-stroke-a-case-report
#11
Min Cheol Chang
[Purpose] This study report a case of a patient with hemiparetic stroke who showed significantly reduced foot pain when ankle spasticity was reduced using nerve and motor point blocks with 20% ethyl alcohol. [Subject and Methods] A 58-year-old woman with left hemiparesis following intracranial hemorrhage five years previously presented with pain in the left fifth metatarsal head for two years (numeric rating scale[NRS]: 8). Erythema and edema were observed on the lateral aspect of the head of the fifth metatarsal bone...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28504809/effect-of-lymphedema-treatment-for-management-of-acute-pilon-fractures
#12
John M Whatley, James A Lalonde, Craig C Greene, Kevin B Riche, Danielle M Tatum
Pilon fractures are high-energy injuries that often result in considerable edema and compromise of the soft tissue envelope of the ankle. These injuries are typically staged with an external fixator until the soft tissue is amenable for definitive fixation. This study was conducted to determine the effects of lymphedema treatment for the management of pilon fractures. Patients who underwent open reduction and internal fixation of pilon fractures between 2007 and 2014 at the authors' level II trauma center were identified by Current Procedural Terminology codes indicative of placement of an external fixator (20690) and open reduction and internal fixation of a pilon fracture (27826, 27827, or 27828)...
July 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/28480735/letter-regarding-high-prevalence-of-vitamin-d-deficiency-in-patients-with-bone-marrow-edema-syndrome-of-the-foot-and-ankle
#13
Andrzej Boszczyk
No abstract text is available yet for this article.
July 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28465773/treatment-patterns-and-outcomes-in-patients-with-varicose-veins
#14
Rajiv Mallick, Aditya Raju, Chelsey Campbell, Rashad Carlton, David Wright, Kimberly Boswell, Michael Eaddy
BACKGROUND: Approximately 24% of adults in the United States have visible varicose veins, and an estimated 6% have evidence of advanced chronic venous disease. The majority of individuals with varicose veins seek treatment because of symptoms, such as aching, throbbing, fatigue, pruritus, ankle swelling, and tenderness, rather than cosmetic reasons. Furthermore, varicose veins are a manifestation of chronic venous insufficiency, which can progress to leg pain, leg edema, chronic skin changes, and nonhealing ulcers...
November 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/28454202/-new-developments-in-compression-treatment
#15
Stefanie Reich-Schupke, Kerstin Protz, Joachim Dissemond, Eberhard Rabe
Patients with peripheral arterial occlusive disease who show an ankle arterial pressure of minimum 60 mmHg can be decongested by use of special padded bandages. Afterwards, medical compression stockings (class 1) with high strength and less elasticity are recommended. Mobile patients seem to benefit from progressive compression therapy with highest pressure above the calf. Compression after uncomplicated interventions of varicose veins or spider veins tends to be modified to a short and excentric compression in patients without risk factors...
May 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28454064/withaferin-a-a-steroidal-lactone-encapsulated-mannose-decorated-liposomes-ameliorates-rheumatoid-arthritis-by-intriguing-the-macrophage-repolarization-in-adjuvant-induced-arthritic-rats
#16
Farhath Sultana, Manoj Kumar Neog, MahaboobKhan Rasool
In order to develop a better therapeutic approach for the treatment of rheumatoid arthritis (RA), withaferin-A; a steroidal lactone incorporated with mannosylated liposomes (ML-WA) was administered to adjuvant induced arthritic rats in intent to target the synovial macrophages. The confocal microscopy studies showed a successful internalization of ML-WA in the primarily isolated synovial macrophages. Consequently, targeting synovial macrophages via ML-WA reduced the oxidative stress (ROS and NO), and paw edema, however, a progressive gain in the body weight was observed in AIA rats...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28444097/chronic-polyarthritis-as-the-first-manifestation-of-childhood-systemic-polyarteritis-nodosa
#17
Glaucia Vanessa Novak, Koken Hayashi, Kohei Sampa, Yosuke Okumura, Gabriela Ribeiro Viola Ferreira, Clovis Artur Silva
Arthritis has been reported as an acute pattern, generally evanescent with oligoarthritis, mostly affecting knees and ankles in childhood systemic polyarteritis nodosa. However, chronic polyarthritis with morning stiffness mimicking juvenile idiopathic arthritis has not been reported. We describe the case of a 4-year old girl who had additive and chronic polyarthritis with edema, tenderness, pain on motion and morning stiffness for 2 months. After 45 days, she also presented painful subcutaneous nodules and erythematous-violaceous lesions in the extensor region of upper and lower limbs...
January 2017: Einstein
https://www.readbyqxmd.com/read/28438383/remitting-seronegative-symmetrical-synovitis-with-pitting-edema-rs3pe-syndrome-induced-by-nivolumab
#18
Marie-Léa Gauci, Barouyr Baroudjian, Pauline Laly, Isabelle Madelaine, Laetitia Da Meda, Laetitia Vercellino, Martine Bagot, Frédéric Lioté, Cécile Pages, Céleste Lebbé
INTRODUCTION: A new articular syndrome described as immunrelated side effect of immunotherapy: PD-1 inhibitors have revolutionized the treatment of advanced melanoma but are responsible for immune-related toxicity. We report a case of remitting seronegative symetrical synovitis with pitting edema (RS3PE) syndrome induced by nivolumab. CASE REPORT: A 80 year-old man with stage IV BRAF-wild type and NRAS exon 2-mutated melanoma was treated first line by nivolumab 3mg/kg every 2 weeks...
March 8, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28386571/the-broken-ring-of-fire-a-new-radiological-sign-as-predictor-of-syndesmosis-injury
#19
James Calder, Adam Mitchell, Adam Lomax, Moez S Ballal, John Grice, Niek van Dijk, Justin Lee
BACKGROUND: Subcircumferential periosteal edema above the ankle joint is frequently present on magnetic resonance imaging (MRI) with syndesmosis injuries but has not been previously reported. Fluid height within the interosseous membrane also has not previously been shown to be associated with syndesmosis injury severity. PURPOSE: To investigate whether a new sign on MRI and measurement of the length of fluid within the interosseous membrane above the ankle may be used to enable identification of a syndesmosis injury and allow differentiation from lateral ligament injury...
March 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28357106/persistent-arthralgia-vomiting-and-hypercalcemia-as-the-initial-manifestations-of-hyperthyroidism-a-case-report
#20
Jingfang Liu, Xulei Tang, Jianguo Cheng, Xiaomei Yang, Yan Wang
A 53-year-old woman presented with persistent edema and pain of the metacarpophalangeal and proximal interphalangeal joints and the wrist, knee and ankle joints, with more recent intermittent nausea and vomiting. Treatment for rheumatoid arthritis and osteoarthritis was ineffective. No clinical manifestations typical of hyperthyroidism were observed. The results of the thyroid function tests were as follows: Thyroid-stimulating hormone, 0.003 µIU/ml; triiodothyronine (T3), 4.44 ng/ml;, thyroxine (T4) >30 µg/dl; free T3, 14...
February 2017: Molecular and Clinical Oncology
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