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https://www.readbyqxmd.com/read/29902847/-experimental-study-on-nasal-mucosa-injury-and-repair-induced-by-nasal-decongestants-in-guinea-pigs
#1
Y N Wang, H T Wang
Objective: To observe the process of nasal mucosa injury and repair induced by nasal decongestants in guinea pigs Methods: Sixty-five male guinea pigs were randomly divided into 4groups by digital random method.The guinea pigs in Group A (20 guinea pigs)were treated with 2 sprays of 0.1% Naphazoline 6 times a day for 2 weeks; Group B (20 guinea pigs)with 2 drops of 1% Ephedrine 6 times a day for 2 weeks; Group C(20 guinea pigs) with 2 sprays of Naphazolin hydrochloride and Chlorphenamine Maleate Nasal Spray 8 times a day for 2 weeks...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29895875/lymphedema-techniques-to-manage-edema-after-sci-a-retrospective-analysis
#2
Rebecca Hammad, Catherine Furbish, W Mark Sweatman, Edelle C Field-Fote
STUDY DESIGN: Retrospective analysis of treatment data for a cohort of clients with spinal cord injury (SCI) who received therapy for management of edema. OBJECTIVE: To evaluate the safety, feasibility, and benefit of a modified lymphedema treatment approach for treatment of chronic lower extremity edema in persons with SCI. SETTING: A specialty rehabilitation hospital in Atlanta, GA, USA. METHODS: Certified lymphedema therapists with experience in SCI rehabilitation modified standard complete decongestive therapy (CDT) techniques to accommodate sensory and motor impairments and ensure skin safety...
June 12, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29894349/anesthetic-considerations-for-a-patient-with-chronic-systemic-capillary-leak-syndrome-a-case-report
#3
Resham Datta, Jason K Panchamia
Systemic capillary leak syndrome (SCLS) is an idiopathic vascular hyperpermeability that leads to profound hypotension, hypoalbuminemia, and hemoconcentration. Sixty years since its inauguration into literature, SCLS is still elusive, underdiagnosed, and profoundly dangerous. Few authors have documented anesthetic implications of classical acute SCLS, a form with complete recovery between exacerbations. However, minimal information is available about chronic SCLS, continuous generalized edema with or without exacerbations...
June 11, 2018: A&A practice
https://www.readbyqxmd.com/read/29891833/x-linked-dilated-cardiomyopathy-presenting-as-acute-rhabdomyolysis-and-presumed-epstein-barr-virus-induced-viral-myocarditis-a-case-report
#4
Jacques A J Malherbe, Sue Davel
BACKGROUND Rhabdomyolysis and primary dilated cardiomyopathies without skeletal muscle weakness are rare features of X-linked dystrophinopathies. We report a rare case of an X-linked dilated cardiomyopathy (XLDCM) presenting with acute rhabdomyolysis and myocarditis. We illustrate the confounding diagnostic influence of a reactivated, persistent EBV myocarditis as the presumed cause for this patient's XLDCM. CASE REPORT A 23-year-old Australian man presented with acute rhabdomyolysis and elevated creatine kinase (CK) levels...
June 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29891070/toxic-induced-cerebellar-syndrome-from-the-fetal-period-to-the-elderly
#5
Mario Manto, Gaetano Perrotta
The cerebellum is a brain region which is particularly susceptible to intoxication. Clinical presentation is heterogeneous. It is often considered that elderly patients and patients presenting pre-existing structural lesions of the posterior fossa are particularly at risk of developing a toxic-induced cerebellar syndrome (TOICS). However, TOICS may occur at any age, including in utero. Indeed, the cerebellum is highly vulnerable during neurodevelopment. Amongst cerebellotoxic agents, ethanol is the most commonly implicated...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29888010/dasatinib-induced-pulmonary-arterial-hypertension-treated-with-upfront-combination-therapy
#6
Makoto Nishimori, Tomoyuki Honjo, Kenji Kaihotsu, Naohiko Sone, Sachiko Yoshikawa, Junichi Imanishi, Kazuhiko Nakayama, Noriaki Emoto, Masanori Iwahashi
Pulmonary arterial hypertension (PAH) is a rare complication of dasatinib that was approved as a first-line therapy for chronic myelocytic leukemia (CML). A 24-year-old man presenting dyspnea at rest and leg edema was admitted to our hospital. He had been diagnosed with CML and prescribed dasatinib for 4 years. Chest X-ray showed significant bilateral pleural effusion and heart enlargement. Echocardiography revealed interventricular septal compression and elevated peak tricuspid regurgitation pressure gradient of 66...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29885366/increased-phosphorylation-of-enos-in-nasal-polyps-of-chronic-rhinosinusitis-patients-can-be-diminished-by-1-8-cineol
#7
Michael Koennecke, Frederick Benecke, Anja Masche, Robert Linke, Karl-Ludwig Bruchhage, Ralph Pries, Ludger Klimek, Barbara Wollenberg
INTRODUCTION: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a significant health problem, but the pathogenesis remains unclear to date. Nitric oxide (NO) has known airway modulating functions. Therefore, we investigated nitric oxide production to determine the role of eNOS in nasal polyps, with additional analysis of the effect of the monoterpene oxide 1,8-cineol on the possible regulation of eNOS signaling and thus NO production. METHODS: We determined eNOS expression, as well as regulatory and effector proteins like NOSTRIN and CASP8, using whole genome microarray, immunohistochemistry and western blot...
June 6, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29883362/morphological-and-crystal-chemical-characteristic-of-pan%C3%B1-reatic-lithiasis
#8
Oleksandr V Kravets, Ihor A Danilenko, Olga M Smorodska, Artem M Piddubnyi, Inna-Margaryta S Zakorko, Sergei N Danilchenko, Roman A Moskalenko, Mykola G Kononenko, Anatolii M Romaniuk
OBJECTIVE: Introduction: Information on chemical and phase composition of pancreoliths is limited and discrepant. There are reports, that pancreoliths are composed by calcium, phosphate, calcium carbonate or combination of calcium with fatty acids The aim of the work is studying of structural characteristics of pancreatoliths in 5 clinical cases. PATIENTS AND METHODS: Materials and methods: Morphological and crystal-chemical study of five cases of pathological biomineralization in the pancreas were conducted in the work...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29880317/characteristics-of-laryngopharyngeal-reflux-in-patients-with-chronic-otitis-media
#9
Honglei Han, Qiuping Lv
OBJECTIVE: To summarize the characteristics of laryngopharyngeal reflux (LPR) in patients with chronic otitis media. METHODS: This was a prospective study in which 31 patients with chronic otitis media were enrolled. General patient information, reflux symptom index (RSI), reflux finding scores (RFSs), and Ryan scores were summarized. RESULTS: Most (29/31, 93.5%) patients had a negative RSI (RSI ≤ 13). The most common symptoms of these patients were throat clearing (22/31, 71...
May 22, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29879127/weight-estimation-for-children-aged-6-to-59-months-in-limited-resource-settings-a-proposal-for-a-tape-using-height-and-mid-upper-arm-circumference
#10
Mark E Ralston, Mark A Myatt
IMPORTANCE: A simple, reliable tool for rapid estimation of weight in children would be useful in limited-resource settings where current weight estimation tools are not reliable, nearly all global under-five mortality occurs, severe acute malnutrition is a significant contributor in approximately one-third of under-five mortality, and a weight scale may not be immediately available to healthcare professionals including first-response providers. OBJECTIVE: To test the accuracy and precision of an existing weight estimation tool based on patient height and mid-upper arm circumference (MUAC) in children between six months and five years of age in low-to-middle income countries...
2018: PloS One
https://www.readbyqxmd.com/read/29877106/polysaccharides-from-citrus-grandis-associate-with-luteolin-relieves-chronic-pharyngitis-by-anti-inflammatory-via-suppressing-nf-%C3%AE%C2%BAb-pathway-and-the-polarization-of-m1-macrophages
#11
Xiumei Chen, Yongfeng Lai, Xicheng Song, Jinying Wu, Li Wang, Hua Zhang, Zhonglu Liu, Yan Wang
Chronic pharyngitis is characterized as a common inflammation of the pharyngeal mucosa, and anti-inflammatory medications are the common treatment to relieve it. Polysacharides of Citrus grandis L. Osbeck (PCG) and luteolin have been reported to have anti-inflammatory activities. In this study, the protective effects of PCG and luteolin on chronic pharyngitis are evaluated and the underlying mechanisms are explored. PCG and luteolin are administrated to animal models with granuloma, ear edema and chronic pharyngitis and the effects of PCG and luteolin on disease severity are evaluated...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29876144/subconjunctival-exposure-to-carbopol-causes-chronic-histiocytic-inflammatory-response-in-rabbits
#12
Lauren A Dalvin, Diva R Salomão, Raymond Iezzi, Andrew J Barkmeier
Purpose: We recently reported a clinical association between surgical exposure to the ophthalmic lubricant GenTeal gel and postoperative subconjunctival necrotizing granulomatous inflammation. We used a rabbit model to test our hypothesis that subconjunctival exposure to the carbopol 980 component is responsible for inciting chronic inflammation. Methods: Of eight adult wild-type Dutch belted rabbits, 16 eyes received subconjunctival injections of the following: hydroxypropyl methylcellulose (HPMC) 0...
May 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29874834/pathophysiological-mechanisms-of-chronic-venous-disease-and-implications-for-venoactive-drug-therapy
#13
REVIEW
Armando Mansilha, Joel Sousa
Chronic venous disease (CVD) is a common pathology, with significant physical and psychological impacts for patients and high economic costs for national healthcare systems. Throughout the last decades, several risk factors for this condition have been identified, but only recently, have the roles of inflammation and endothelial dysfunction been properly assessed. Although still incompletely understood, current knowledge of the pathophysiological mechanisms of CVD reveals several potential targets and strategies for therapeutic intervention, some of which are addressable by currently available venoactive drugs...
June 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29871770/morphological-and-ultrastructural-changes-in-the-placenta-of-the-diabetic-pregnant-egyptian-women
#14
Nabila Yousef Abdelhalim, Mohammed Hany Shehata, Hanan Nabih Gadallah, Walaa Mohamed Sayed, Aref Ali Othman
Diabetes mellitus (DM) is a chronic metabolic disease in which the body fails to produce enough insulin or increased tissue resistance to insulin. The diabetes may have profound effects on placental development and function. This study was designed to detect the placental changes in pregnancy associated with DM comparing these changes with normal placenta. The study was carried out on sixty full-term placentae; divided into three equal groups; control group (group I): placentae of normal pregnancy, uncontrolled diabetes (group II): placentae from pregnant women whose blood glucose is poorly controlled during pregnancy...
June 2, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29870437/anatomic-considerations-in-thyroid-eye-disease
#15
Jonathan J Dutton
PURPOSE: To review and summarize the clinical findings in thyroid eye disease (TED) related to the unique anatomical structures of the eyelids and orbit. METHODS: A PubMed search was performed searching for anatomical relationships between eyelid and orbital anatomy and the clinical findings of TED. RESULTS: The major clinical findings associated with TED are varied. They typically involve both the eyelid and the orbit. In the eyelid, usual findings include upper eyelid retraction, contour abnormalities, eyelid edema, prolapsed orbital fat, conjunctival injection and chemosis, caruncular edema, and meibomian gland dysfunction...
May 10, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29867576/rho-kinase-inhibition-ameliorates-dasatinib-induced-endothelial-dysfunction-and-pulmonary-hypertension
#16
Csilla Fazakas, Chandran Nagaraj, Diana Zabini, Attila G Végh, Leigh M Marsh, Imola Wilhelm, István A Krizbai, Horst Olschewski, Andrea Olschewski, Zoltán Bálint
The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even pulmonary arterial hypertension. To understand how dasatinib causes endothelial dysfunction we examined the effects of clinically relevant concentrations of dasatinib on both human pulmonary arterial macro- and microvascular endothelial cells (ECs). The effects of dasatinib was compared to imatinib and nilotinib, two other clinically used BCR/Abl kinase inhibitors that do not inhibit Src...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29857972/balloon-pulmonary-angioplasty-for-inoperable-patients-with-chronic-thromboembolic-pulmonary-hypertension-observational-study-in-a-referral-unit
#17
Maite Velázquez, Agustín Albarrán, Ignacio Hernández, M Jesús López-Gude, Fernando Sarnago, Roberto Martín, Fernando Arribas, Pilar Escribano
INTRODUCTION AND OBJECTIVES: Balloon pulmonary angioplasty (BPA) for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) is becoming widely accepted. Procedural refinement has reduced complications. Our primary objective was to analyze the results and complications of the first national BPA program. METHODS: Observational, prospective series that included all consecutive BPA procedures in inoperable CTEPH patients between May 2013 and February 2017 performed at a single institution...
May 29, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29851143/antiarrhythmic-effect-linked-to-melatonin-cardiorenal-protection-involves-at-1-reduction-and-hsp70-vdr-increase
#18
Natalia Jorgelina Prado, Mariana Casarotto, Juan Pablo Calvo, Luciana Mazzei, Amira Zulma Ponce Zumino, Isabel Mercedes García, Fernando Darío Cuello-Carrión, Miguel Walter Fornés, León Ferder, Emiliano Raúl Diez, Walter Manucha
Lethal ventricular arrhythmias increase in patients with chronic kidney disease that suffer an acute coronary event. Chronic kidney disease induces myocardial remodeling, oxidative stress, and arrhythmogenesis. A manifestation of the relationship between kidney and heart is the concomitant reduction in vitamin D receptor (VDR) and the increase in angiotensin II receptor type 1 (AT1 ). Melatonin has renal and cardiac protective actions. One potential mechanism is the increase of the heat shock protein 70 (Hsp70) -an antioxidant factor-...
May 31, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29846987/high-power-and-short-duration-ablation-for-pulmonary-vein-isolation-safety-efficacy-and-long-term-durability
#19
Michael Barkagan, Fernando M Contreras-Valdes, Eran Leshem, Alfred E Buxton, Hiroshi Nakagawa, Elad Anter
INTRODUCTION: PV reconnection is often the result of catheter instability and tissue edema. High-power short-duration (HP-SD) ablation strategies have been shown to improve atrial linear continuity in acute pre-clinical models. This study compares the safety, efficacy and long-term durability of HP-SD ablation with conventional ablation. METHODS AND RESULTS: In 6 swine, 2 ablation lines were performed anterior and posterior to the crista terminalis, in the smooth and trabeculated right atrium, respectively; and the right superior PV was isolated...
May 30, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29807724/an-outbreak-of-hemolytic-uremic-syndrome-in-southern-romania-during-2015-2016-epidemiologic-clinical-laboratory-microbiologic-therapeutic-and-outcome-characteristics
#20
Mihaela Balgradean, Anca Croitoru, Eugene Leibovitz
BACKGROUND AND AIMS: To describe the epidemiologic, clinical, microbiological, therapeutic and outcome characteristics of a HUS outbreak occurring in southern Romania from 2015 to 2016. METHODS: We retrospectively collected data from the medical records of all HUS cases hospitalized at the pediatric nephrology department of Marie Curie Children's Hospital of Bucharest, Romania. RESULTS: There were 32 HUS cases (19 girls/13 boys, 87.6% <2 years), all associated with diarrhea (bloody in 13, 40...
May 8, 2018: Pediatrics and Neonatology
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