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Chronic edema

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https://www.readbyqxmd.com/read/29456949/clarithromycin-in-the-management-of-chronic-rhinosinusitis-preliminary-results-of-a-possible-its-new-use
#1
F Sireci, R Speciale, S Gallina, R Sorrentino, F R Canevari
The aim of this study is to evaluate the efficacy and safety of prolonged therapy with low-dose clarithromycin in patients with chronic rhinosinusitis with polyps (CRSwP) after endoscopic sinus surgery (ESS). A total of 10 patients with CRSwP were identified and subjected to bilateral ESS. In post-operative patients they were treated with nasal wash with saline solution and steroid sprays (beclomethasone). During follow-up, after 30-40 days after the operation (M = 35.4 SD = +4.33), patients reported a worsening of symptoms with onset of nasal obstruction; reduction/loss of smell; headache; onset of viscous secretions and therefore all patients continued therapy with saline nasal irrigation, topical steroid therapy and started macrolide (clarithromycin 500 mg/pill: 1 pill/day for 3 days a week for 1 month)...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456816/anti-inflammatory-activity-and-chemical-composition-of-pycnocycla-bashagardiana-fruit-s-essential-oil-in-animal-models
#2
Fatemeh Jahandar, Jinous Asgarpanah, Parvaneh Najafizadeh, Zahra Mousavi
Objectives: Pycnocycla bashagardiana is an endemic species found only in Iran. Due to the presence of myristicin as the major component of the fruit's oil we were prompted to assess the antinociceptive and anti-inflammatory properties of P. bashagardiana fruit's essential oil (PBFEO). Materials and Methods: The analgesic activities of PBFEO (100, 200, and 400 mg/kg, IP) were studied by hot-plate and formalin tests in mice. Control and standard groups received vehicle and morphine (5 mg/kg, IP), respectively...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29455725/anti-inflammatory-effect-of-external-use-of-escin-on-cutaneous-inflammation-possible-involvement-of-glucocorticoids-receptor
#3
Shu-Qi Zhao, Shi-Qiang Xu, Jing Cheng, Xiao-Lu Cao, Ying Zhang, Wei-Ping Zhou, Yan-Juan Huang, Jun Wang, Xia-Min Hu
Escin, as an internally applied anti-inflammatory agent, has been widely used in the treatment of inflammation and edema resulting from trauma or operation in the clinic. However, the effect of its external use on cutaneous inflammation and edema remains unexplored. In the present study, the anti-inflammatory and anti-edematous effects of external use of escin were studied in carrageenan-induced paw edema and histamine-induced capillary permeability in rats, paraxylene-induced ear swelling in mice, and cotton pellet-induced granuloma in rats...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29451512/-antegrade-and-retrograde-approach-through-the-venous-graft-for-treating-a-chronic-total-occlusion-in-a-patient-with-acute-coronary-syndrome-complicated-by-pulmonary-edema
#4
Francesco Gallo, Matteo Tebaldi, Carlo Tumscitz
Percutaneous treatment of chronic total occlusions (CTO) is one of the major challenges in contemporary interventional cardiology. These lesions are identified in 15% to 30% of all patients referred for coronary angiography. Percutaneous coronary intervention (PCI) of CTOs is technically challenging and requires familiarity with advanced interventional techniques as well as specialty equipment. The choice of strategy and materials is based on clinical features and coronary anatomy; the correct choice is essential to improve the success probability...
January 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29449520/-a-case-of-hypertrophic-pachymeningitis-with-symptomatic-venous-congestion-due-to-sinus-stenosis
#5
Sho Umegaki, Shin-Ichiro Osawa, Kensuke Kimura, Toshimi Okushima, Nobuhisa Yajima, Tsuyoshi Kawamura, Teiji Tominaga
We report a patient with hypertrophic pachymeningitis and symptomatic stenosis of the superior sagittal sinus. A 71-year-old man presented with right hemiparesis, sensory-dominant aphasia, and right hemispatial neglect that had been worsening over 2 weeks. Computed tomography showed isodense crescent-shaped lesions deforming the surface of the left cerebral hemisphere, mimicking a subdural hematoma with atypical perifocal edema in the left parietal lobe. Magnetic resonance imaging showed diffuse thickening of the dura mater with contrast enhancement of his left cerebral hemisphere...
February 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29432067/community-based-treatment-for-chronic-edema-an-effective-service-model
#6
Christine J Moffatt, Debra C Doherty, Peter J Franks, Peter S Mortimer
BACKGROUND: Chronic edema care is patchy and of variable quality internationally. This study was undertaken to develop and evaluate a system of care that would provide for patients within a geographical area of London (Wandsworth), United Kingdom. METHODS AND RESULTS: A prospective cohort design with intervention of a new service design following a 6-month baseline period. Patients were identified through health professionals. A stratified random sample was drawn from all patients and an implementation strategy developed...
February 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29423395/plasma-prekallikrein-its-role-in-hereditary-angioedema-and-health-and-disease
#7
REVIEW
Alvin H Schmaier
Plasma prekallikrein (PK) has a critical role in acute attacks of hereditary angioedema (HAE). Unlike C1 inhibitor, its levels fall during HAE attacks with resultant cleaved high-molecular-weight kininogen. Cleavage of high-molecular-weight kininogen liberates bradykinin, the major biologic peptide that promotes the edema. How prekallikrein initially becomes activated in acute attacks of HAE is not known. PK itself is negatively associated with cardiovascular disease. High prekallikrein is associated with accelerated vascular disease in diabetes and polymorphisms of prekallikrein that reduce high-molecular-weight kininogen binding are associated with protection from cardiovascular events...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29422811/duodenal-amyloidosis-secondary-to-ulcerative-colitis
#8
Seung Woon Park, Sam Ryong Jee, Ji Hyun Kim, Sang Heon Lee, Jin Won Hwang, Ji Geon Jang, Dong Woo Lee, Sang Yong Seol
Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinal diseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old male patient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29422758/localized-trichiasis-causing-focal-full-thickness-corneal-edema-endothelial-cell-loss-and-corneal-scarring-requiring-penetrating-keratoplasty
#9
Tiffany Sara Liu, Seth Meskin
The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Specular microscopy showed diffuse endothelial cell loss. He was treated with topical steroids and acyclovir with epilation of lashes. Anterior chamber paracentesis was negative for varicella-zoster virus, cytomegalovirus, and herpes simplex virus...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29420160/mito-tempo-prevents-nicotine-induced-exacerbation-of-ischemic-brain-damage
#10
Chun Li, Hong Sun, Guodong Xu, Kimberly D McCarter, Jiyu Li, William G Mayhan
Nicotine may contribute to the pathogenesis of cerebrovascular disease via the generation of reactive oxygen species (ROS). Overproduction of ROS leads to brain damage by intensifying post-ischemic inflammation. Our goal was to determine the effect of Mito-Tempo, a mitochondria-targeted antioxidant, on ischemic brain damage and post-ischemic inflammation during chronic exposure to nicotine. Male Sprague-Dawley rats were divided into four groups: control, nicotine, Mito-Tempo-treated control, and Mito-Tempo-treated nicotine...
February 8, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29414503/ileo-ileal-fistula-with-severe-malnutrition-caused-by-strangulated-ileus-surgery-while-preserving-ischemic-ileum-a-case-report
#11
Satoshi Nishiwada, Shinji Nakamura, Tetsuya Tanaka, Yuki Kirihataya, Daiki Nezu, Nobuhiro Sawa, Naoki Fujita, Haruka Ikegami, Atsushi Yoshimura
INTRODUCTION: Entero-enteric fistulas are rare complications that occur in patients with inflammatory bowel disease and other intestinal diseases. In this report, we present an ileo-ileal fistula accompanied by severe malnutrition caused by strangulated ileus surgery while preserving the ischemic ileum in a very elderly patient. CASE PRESENTATION: A 90-year-old woman underwent emergency surgery without bowel resection for strangulated ileus in another hospital. Minor abdominal pain and slight fever persisted after surgery...
January 27, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29411715/evaluation-of-fractioned-nitric-oxide-in-chronic-cough-patients
#12
Y Yildiz, M Igde
INTRODUCTION: Cough exceeding 3-8 weeks was defined as chronic cough in various guides. Asthma is the most common cause of chronic-specific cough. Causes other than asthma include prolonged bacterial bronchitis and upper airway cough syndrome (UACS). Nitric oxide (NO) causes vascular smooth muscle relaxation, bronchodilation, and oxidant effects via its metabolite, peroxynitrite. An increase in NO results in inflammation, vasodilatation, and bronchial edema. MATERIALS AND METHODS: The study group included 90 patients aged 6-17 years selected from individuals presenting to the Pediatric Immunology and Allergic Diseases Clinic with cough persisting for 4 weeks and 30 other patients representing to the control group...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29411336/central-sleep-apnea-with-cheyne-stokes-breathing-in-heart-failure-from-research-to-clinical-practice-and-beyond
#13
K Terziyski, A Draganova
Characterized by periodic crescendo-decrescendo pattern of breathing alternating with central apneas, Central sleep apnea (CSA) with Cheyne-Stokes Breathing represents a highly prevalent, yet underdiagnosed comorbidity in chronic heart failure (CHF). A diverse body of evidence demonstrates increased morbidity and mortality in the presence of CSB. CSB has been described in both CHF patients with preserved and reduced ejection fraction, regardless of drug treatment. Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29408167/predicting-cardiogenic-pulmonary-edema-in-heart-failure-patients-by-using-an-n-terminal-pro-b-type-natriuretic-peptide-nt-pro-bnp-based-score
#14
Xin-Yi Liu, Ya-Ting Huang, Min-Yu Lai, John Chen, Tung-Wei Chu, Pei-Kwei Tasy, Chih-Chung Shiao
BACKGROUND: Cardiogenic pulmonary edema (CPE) is a life-threatening emergency necessitating aggressive management. We conducted this study to test the hypothesis that a combination of N-terminal pro-b-type natriuretic peptide (NT-pro-BNP) and some relevant clinical factors may provide better predictability for CPE in heart failure (HF) patients. METHODS: This retrospective study enrolled adult HF patients hospitalized during January 2011 to December 2013. After determining the independent predictors for the occurrence of CPE, a novel NT-pro BNP-based diagnostic score for predicting CPE was established...
January 27, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29407737/enhancing-the-fathead-minnow-fish-embryo-toxicity-test-optimizing-embryo-production-and-assessing-the-utility-of-additional-test-endpoints
#15
Kyle S Roush, Julie C Krzykwa, Jacob A Malmquist, Dane A Stephens, Marlo K Sellin Jeffries
The fathead minnow fish embryo toxicity (FET) test has been identified as a potential alternative to toxicity test methods that utilize older fish. However, several challenges have been identified with the fathead minnow FET test, including: 1) difficulties in obtaining appropriately-staged embryos for FET test initiation, 2) a paucity of data comparing fathead minnow FET test performance to the fathead minnow larval growth and survival (LGS) test and 3) a lack of sublethal endpoints that could be used to estimate chronic toxicity and/or predict adverse effects...
February 1, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29407089/basal-functional-status-predicts-one-year-mortality-after-a-heart-failure-hospitalization-in-elderly-patients-the-rica-prospective-study
#16
David Chivite, Francesc Formiga, Xavier Corbella, Alicia Conde-Martel, Óscar Aramburu, Margarita Carrera, Melitón Francisco Dávila, José Pérez-Silvestre, Luis Manzano, Manuel Montero-Pérez-Barquero
BACKGROUND: Dependence for basic activities of the daily living (ADL) relates to adverse outcomes in elderly acute heart failure (AHF) patients. METHODS: We evaluated patients ≥75years admitted because of AHF, divided according to preadmission Barthel Index (BI) category: severe (BI 0-60), moderate (BI 61-90) and slight dependence or independence for basic ADL (BI 91-100). We compared their baseline characteristics and used logistic regression models to determine whether a BI≤60 confers higher one-year mortality risk...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29406237/a-68-year-old-man-with-chronic-myelogenous-leukemia-and-a-large-unilateral-pleural-effusion
#17
Adam Alter, Neal Chaisson, Sudipto Mukherjee, Thomas Gildea
A 68-year-old man with chronic myelogenous leukemia presents for evaluation of 2 months of dyspnea with exertion. He denies cough, fever, chest pain, weight gain, orthopnea, and edema. Since diagnosis of chronic myelogenous leukemia 5 years ago, he has been treated with dasatinib, with recent BCR-ABL1 assay showing no detectable disease in the peripheral blood. Medical history also includes hyperlipidemia, prostate enlargement, and hypothyroidism, but no prior heart or lung disease. Born in the Middle East, he immigrated to the United States 30 years ago and is working as a physician...
February 2018: Chest
https://www.readbyqxmd.com/read/29394119/safety-and-efficacy-of-intravitreal-dexamethasone-implant-for-refractory-uveitic-macular-edema-in-adults-and-children
#18
Dhanashree Ratra, Atanu Barh, Manideepa Banerjee, Vineet Ratra, Jyotirmay Biswas
PURPOSE: To assess safety and efficacy of intravitreal dexamethasone (DEX) implant in refractory uveitic macular edema (ME). METHODS: We retrospectively analyzed medical records of patients with nonresponsive ME secondary to chronic, noninfectious intermediate or posterior uveitis, treated with intravitreal DEX implants. RESULTS: A total of 42 eyes of 34 patients (aged 6-67 years) received 56 implants. Mean follow-up was 19.2 ± 2.2 months after DEX implant...
February 2, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29392288/persistent-macular-thickening-following-intravitreous-aflibercept-bevacizumab-or-ranibizumab-for-central-involved-diabetic-macular-edema-with-vision-impairment-a-secondary-analysis-of-a-randomized-clinical-trial
#19
Neil M Bressler, Wesley T Beaulieu, Adam R Glassman, Kevin J Blinder, Susan B Bressler, Lee M Jampol, Michele Melia, John A Wells
Importance: Prevalence of persistent central-involved diabetic macular edema (DME) through 24 weeks of anti-vascular endothelial growth factor therapy and its longer-term outcomes may be relevant to treatment. Objective: To assess outcomes of DME persisting at least 24 weeks after randomization to treatment with 2.0-mg aflibercept, 1.25-mg bevacizumab, or 0.3-mg ranibizumab. Design, Setting, and Participants: Post hoc analyses of a clinical trial, DRCR...
February 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29388467/emerging-therapeutics-in-pulmonary-hypertension
#20
Matthew K Hensley, Andrea Levine, Mark T Gladwin, Yen-Chun Lai
Pulmonary hypertension (PH) is a progressive and often fatal illness presenting with nonspecific symptoms of dyspnea, lower extremity edema, and exercise intolerance. Pathologically, endothelial dysfunction leads to abnormal intimal and smooth muscle proliferation along with reduced apoptosis, resulting in increased pulmonary vascular resistance (PVR) and elevated pulmonary pressures. PH is subdivided into five WHO groups based on the disease pathology and specific cause. While there are FDA-approved medications for the treatment of pulmonary arterial hypertension (PAH, Group 1 PH), as well as for chronic thromboembolic pulmonary hypertension (CTEPH, Group 4 PH), the morbidity and mortality remain high...
February 1, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
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