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https://www.readbyqxmd.com/read/29684510/the-rodent-tibia-fracture-model-a-critical-review-and-comparison-with-the-complex-regional-pain-syndrome-literature
#1
REVIEW
Frank Birklein, Alaa Ibrahim, Tanja Schlereth, Wade S Kingery
Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth) and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified as the primary source of cutaneous cytokines and NGF...
April 20, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#2
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
April 23, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29682579/glomerular-filtration-rate-and-or-ratio-of-urine-albumin-to-creatinine-as-markers-for-diabetic-retinopathy-a-ten-year-follow-up-study
#3
Pedro Romero-Aroca, Marc Baget-Bernaldiz, Raul Navarro-Gil, Antonio Moreno-Ribas, Aida Valls-Mateu, Ramon Sagarra-Alamo, Joan F Barrot-De La Puente, Xavier Mundet-Tuduri
Aims: To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods: A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Results: Annual incidence of any-DR was 8.21 ± 0...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29682525/blood-brain-barrier-damage-as-the-starting-point-of-leukoaraiosis-caused-by-cerebral-chronic-hypoperfusion-and-its-involved-mechanisms-effect-of-agrin-and-aquaporin-4
#4
Jing Huang, Junwen Li, Chao Feng, Xi Huang, Liping Wong, Xueyuan Liu, Zhiyu Nie, Gangming Xi
White matter lesion (WML) is popular in the patients aged over 65. Brain edema and blood-brain barrier (BBB) dysfunction due to cerebral chronic hypoperfusion (CCH) contributed to WML. Preserving astrocyte polarity is vital for BBB integrity. In our experiment, CCH model is established by bilateral carotid arteries occlusion (2VO). Leukoaraiosis was verified by fiber density stain, and brain edema was evaluated using brain water content measuring. The expressions of agrin and aquaporin-4 (AQP4) were evaluated, as well as the integrity of BBB...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682370/fatal-pneumococcus-sepsis-after-treatment-of-late-antibody-mediated-kidney-graft-rejection
#5
Gunilla Einecke, Jan Hinrich Bräsen, Nils Hanke, Hermann Haller, Anke Schwarz
Antibody-mediated rejection (ABMR) is a major cause of late renal allograft dysfunction and graft loss. Risks and benefits of treatment of late ABMR have not been evaluated in randomized clinical trials. We report on a 35-year-old patient with deterioration in renal function and progressive proteinuria 15 years after transplantation. Recurrent infections after a splenectomy following traumatic splenic rupture 3 years earlier had led to reduction of immunosuppression. Renal transplant biopsy showed glomerular double contours, 40% fibrosis/tubular atrophy, peritubular capillaritis, and positive C4d staining indicating chronic-active ABMR...
2018: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29681980/anti-helicobacter-pylori-and-anti-inflammatory-effects-and-constituent-analysis-of-modified-xiaochaihutang-for-the-treatment-of-chronic-gastritis-and-gastric-ulcer
#6
Xin Chen, Lijuan Hu, Huanhuan Wu, Wei Liu, Shuhe Chen, Aijun Zhou, Yanwen Liu
Chronic gastritis and gastric ulcers are prevalent throughout the world and are considered to be a global health problem. Modified Xiaochaihutang (MXCHT) prescription is broadly used in traditional medicine hospital for the treatment of gastritis. In order to assess the anti- Helicobacter pylori (H. pylori) effect of MXCHT, agar diffusion method in vitro and fluid dilution method for the minimal inhibitory concentration (MIC) were established. The anti-inflammatory effects were then evaluated using mouse ear edema model and rat paw edema model...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681836/secondary-angle-closure-due-to-crystalline-lens-dislocation-in-a-patient-with-atopic-dermatitis-and-chronic-eye-rubbing
#7
Justin Kuiper, Mark Slabaugh
Purpose: To report an unusual case of ectopia lentis and angle closure in a patient with chronic eye rubbing. Methods: A 57-year-old male with a history of poorly controlled atopic dermatitis presented with right eye pain, decreased vision, and an intraocular pressure (IOP) of 55 mm Hg. He had no past history of ocular disease and no reported history of trauma. He did report a history of chronic eye rubbing. Results: Best corrected visual acuity was hand motions...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29680356/influence-of-myocardial-hemorrhage-on-staging-of-reperfused-myocardial-infarctions-with-t-2-cardiac-magnetic-resonance-imaging-insights-into-the-dependence-on-infarction-type-with-ex-vivo-validation
#8
Guan Wang, Hsin-Jung Yang, Avinash Kali, Ivan Cokic, Richard Tang, Guoxi Xie, Qi Yang, Joseph Francis, Songbai Li, Rohan Dharmakumar
OBJECTIVES: This study sought to determine whether T2 cardiac magnetic resonance (CMR) can stage both hemorrhagic and nonhemorrhagic myocardial infarctions (MIs). BACKGROUND: CMR-based staging of MI with or without contrast agents relies on the resolution of T2 elevations in the chronic phase, but whether this approach can be used to stage both hemorrhagic and nonhemorrhagic MIs is unclear. METHODS: Hemorrhagic (n = 15) and nonhemorrhagic (n = 9) MIs were created in dogs...
April 14, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29680269/hplc-profile-and-antiedematogenic-activity-of-ximenia-americana-l-olacaceae-in-mice-models-of-skin-inflammation
#9
Bruno Anderson Fernandes da Silva, Roger Henrique Sousa da Costa, Cícera Norma Fernandes, Laura Hévila Inocêncio Leite, Jaime Ribeiro-Filho, Tatiana Rodrigues Garcia, Henrique Douglas Melo Coutinho, Almir Gonçalves Wanderley, Irwin Rose Alencar de Menezes
The aim of this study was to evaluate the anti-edematogenic activity of X. americana L. (HEXA) hydroethanolic extract in ear edema models (acute and chronic) induced by croton oil and by different phlogistic agents (arachidonic acid, capsaicin, phenol and histamine), identifying the possible anti-edematogenic mechanism. HEXA demonstrated a significant anti-edematogenic effect at concentrations of 100-500 μg/ear in ear edema induced by croton oil with higher inhibition of edema of 39.37. However, the concentrations of 100 and 200 μg/ear were taken as a standard, demonstrating the effect in the chronic model induced by croton oil with inhibition of 61...
April 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29679159/notch-1-sirna-and-methotrexate-towards-a-multifunctional-approach-in-rhematoid-arthritis-management-a-nanomedicine-approach
#10
Guang Zhao, Haifei Zhang
PURPOSE: Rheumatoid arthritis (RA) is a chronic inflammatory disease and Notch pathway plays a pivotal role in synoviocytes involved in progression of RA. METHODS: Herein, we have designed a self-assembled polymeric micelles based on polycaprolactone-polyethylene glycol (PCL-PEG) and polyethylenimine-polyethylene glycol (PEI-PEG) was prepared and loaded with methotrexate and Notch-1 siRNA for the effective treatment of rheumatoid arthritis. RESULTS: The MTX/siRNA-loaded polymeric micelles (siM-PM) showed appreciable cellular uptake in Raw264...
April 20, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29669665/diagnosis-pathogenesis-and-treatment-of-chronic-spontaneous-urticaria
#11
Allen P Kaplan
BACKGROUND: Chronic Spontaneous Urticaria (CSU) is an endogenous disorder that is strongly associated with autoimmunity, particularly with immunoglobulin G (IgG) antibody to the alpha subunit of the IgE receptor seen in 35-40% of patients. Basophils and cutaneous mast cells can be activated and lead to a late-phase-like perivascular infiltration about small venules and hive formation. METHODS: Review of current literature. RESULTS: Antibody to thyroid antigens are seen in 25% of patients; a small fraction of these may be clinically hypothyroid (Hashimoto's Thyroiditis)...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29663141/tacrolimus-loaded-peg-cholecalciferol-based-micelles-for-treatment-of-ocular-inflammation
#12
Shallu Kutlehria, Imran Vhora, Arvind Bagde, Nusrat Chowdhury, Gautam Behl, Ketan Patel, Mandip Singh
PURPOSE: Poor corneal permeability, nasolacrimal drainage and requirement of chronic administration are major drawbacks of existing therapies for ocular inflammation. Hence, we designed topical micelles of PEG2000 conjugated with cholecalciferol (PEGCCF). METHODS: Integrin targeted tacrolimus loaded PEGCCF micelles (TTM) were prepared by solvent diffusion evaporation method and characterized for particle size, osmolality, encapsulation efficiency and drug loading...
April 16, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29662323/investigation-of-chronic-efficacy-and-safety-profile-of-two-potential-anti-inflammatory-bipyrazole-based-compounds-in-experimental-animals
#13
Souraya Domiati, Mohammed Mehanna, Hanan Ragab, Hania Nakkash Chmaisse, Ahmed El Mallah
Purpose: Although nonsteroidal anti-inflammatory drugs are widely used to treat a variety of disorders, their administration is associated with gastrointestinal side effects, acute kidney injury and liver enzymes' elevation. Accordingly, researchers are encouraged to create novel agents with better safety profile. The aim of the current study was to evaluate the chronic efficacy and safety profile of two compounds previously proven to have acceptable acute anti-inflammatory and analgesic activities...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29644905/histopathology-in-chronic-rhinosinusitis-varies-with-sinus-culture
#14
Ashley L Heilingoetter, Bobby Tajudeen, Hannah N Kuhar, Paolo Gattuso, Ritu Ghai, Mahboobeh Mahdavinia, Pete S Batra
Background Structured histopathology reporting facilitates better understanding of the underlying pathophysiologic mechanisms of chronic rhinosinusitis. The microbiology of chronic rhinosinusitis has been studied extensively; however, distinct histopathologic changes associated with bacteria isolated in chronic rhinosinusitis are largely unknown. Objective The goal of this study is to better understand the relationship between culturable bacteria and histopathology in chronic rhinosinusitis. Methods A structured histopathology report was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery in a group of patients with chronic rhinosinusitis refractory to medical therapy...
March 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29644035/appendiceal-intussusception-in-the-setting-of-ulcerative-colitis
#15
Paul R Burchard, Alan A Thomay
Appendiceal intussusception is a very rare condition with an estimated incidence of 0.01%. Most cases present in adults with chronic waxing and waning of symptoms over a period of weeks to months. We report a case of a 39-year-old Caucasian female with a 5-week history of worsening right-sided abdominal pain. Computed tomography revealed cecal thickening without visualization of the appendix. A colonoscopy revealed mild diffuse erythema and edema in the ascending colon as well as a mass within the lumen of the cecum...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29628609/management-of-chronic-deep-vein-thrombosis-in-women
#16
REVIEW
Rulon L Hardman
Chronic deep vein thrombosis (DVT) affects hundreds of thousands of women in the United States. Chronic DVT can lead to pain, edema, venous ulcers, and varicosities. While there are limited data regarding the management of chronic DVT, several interventional radiology groups aggressively treat chronic DVT to aid patient symptom resolution. Recanalization of occluded veins and venous stenting re-establishes deep vein flow and decreases venous hypertension.
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29628470/a-rare-case-of-rush-progression-of-purulent-pericarditis-by-escherichia-coli-in-a-patient-with-malignant-lymphoma
#17
Shunpei Horii, Hirotaka Yada, Kei Ito, Ayumu Osaki, Atsushi Sato, Toyokazu Kimura, Risako Yasuda, Takumi Toya, Takayuki Namba, Nobuyuki Masaki, Takeshi Adachi
Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. We report an old male case of purulent pericarditis by Escherichia coli. He came to our hospital suffering from leg edema for 3 months. Echocardiography revealed the large amount of pericardial effusion, and he was admitted to test the cause of pericardial effusion without high fever, tachycardia, and shock vital signs...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29627656/design-synthesis-and-evaluation-of-some-pyrazolo-3-4-d-pyrimidines-as-anti-inflammatory-agents
#18
Gina N Tageldin, Salwa M Fahmy, Hayam M Ashour, Mounir A Khalil, Rasha A Nassra, Ibrahim M Labouta
New pyrazolo[3,4-d]pyrimidines substituted with various functionalities or attached to a substituted pyrazole ring through different linkages were synthesized. The synthesized compounds were evaluated for their anti-inflammatory activity using in vitro COX-1/COX-2 inhibition assay and in vivo formalin induced paw edema and cotton pellet-induced granuloma assays. Results revealed that compounds 17b and 18 possessed COX-1/COX-2 selectivity indices higher than diclofenac sodium and celecoxib. However, compounds 16a,b exhibited selectivity indices higher than diclofenac sodium and nearly equivalent to celecoxib, whereas, 9b displayed selectivity index comparable to diclofenac sodium...
April 3, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29626002/evaluating-off-label-uses-of-acetazolamide
#19
REVIEW
Megan A Van Berkel, Jessica L Elefritz
PURPOSE: Current off-label uses of acetazolamide in hospitalized patients are reviewed. SUMMARY: Acetazolamide is a carbonic anhydrase inhibitor typically used for indications including epilepsy, glaucoma, edema, and altitude sickness but it may be prescribed in hospitalized patients for off-label indications. It inhibits carbonic anhydrase, which leads to reduced hydrogen ion secretion in the proximal renal tubule, resulting in increased bicarbonate and cation excretion and causing urinary alkalization and diuresis...
April 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29625716/-ocular-manifestations-in-beh%C3%A3-et-s-disease
#20
A-C Desbois, C Terrada, P Cacoub, B Bodaghi, D Saadoun
Ocular disease in Behçet's disease is frequent and may be associated with a poor functional prognosis. Uveitis is the most common ocular manifestation in Behçet's disease and represents a diagnostic criterion of the disease. The ocular involvement is inaugural of the disease in 20% of the cases or may develop 2 to 3 years after the beginning of the extraocular signs. The risk of blindness at 5 years is in the order of 15 to 25%, mainly due to macular involvement or retinal vasculitis. Uveitis may be anterior, intermediate, posterior or panuveitis...
April 3, 2018: La Revue de Médecine Interne
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