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https://www.readbyqxmd.com/read/28319576/microscopic-heterotopic-extraovarian-sex-cord-stromal-proliferations-expanding-the-histologic-spectrum
#1
Aisling Longworth, Raji Ganesan, Adrian K H Yoong, Lynn Hirschowitz
Microscopic, heterotopic extraovarian sex cord-stromal proliferations have only recently been reported in the literature. We describe the largest series to date, of 30 cases of microscopic, incidentally detected, heterotopic extraovarian sex cord-stromal proliferation, in women aged 25-79 yr who had undergone surgery for a range of benign and malignant gynecologic conditions. In 14 patients the foci of proliferation comprised ovarian cortical stroma, in some cases with an ovarian fibroma-like appearance. Ten cases of adenofibroma and cystadenofibroma were also identified, including 1 Brenner adenofibroma; 2 cases comprised both ovarian cortical stroma and serous cystadenofibroma; 4 cases showed sex cord proliferation resembling microscopic adult granulosa cell tumors...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28319575/foxl2-mutation-status-in-granulosa-theca-cell-tumors-of-the-ovary
#2
Amber Nolan, Nancy M Joseph, Ankur R Sangoi, Joseph Rabban, Charles Zaloudek, Karuna Garg
Ovarian sex-cord stromal tumors that have between 10% and 50% granulosa cells in a prominent fibrothecomatous background have been referred to as granulosa theca cell tumors or mixed granulosa theca cell tumors. The classification and prognosis of these tumors is not clear. Most adult granulosa cell tumors of the ovary harbor a mutation in the FOXL2 gene, whereas fibromas and thecomas lack this mutation. The aim of our study was to assess the FOXL2 mutation status of ovarian granulosa theca cell tumors and to correlate the mutation status with morphologic and clinical characteristics...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28318171/-chondromyxoid-fibroma-of-the-mandible-a-case-report
#3
Zhou Ying, Zhang Zhihui, Sun Xiaojuan
Chondromyxoid fibroma (CMF) is a rare benign bone tumor. This tumor mostly affects the long bones of the appendicular skeleton but rarely grows in the craniofacial region. In this article, a case of CMF of the mandible was presented to enhance our understanding of CMF. Its clinical manifestations, imaging characteristics, and treatment methods were discussed by analyzing the related literature.
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28316917/a-comparative-study-of-syndecan-1-expression-in-different-odontogenic-tumors
#4
Shahroo Etemad-Moghadam, Mojgan Alaeddini
BACKGROUND: Expression of various cellular/molecular factors change during the course of tumor formation from odontogenic tissues of the tooth germ. Evaluation of these factors can help provide a better perception of the tumorigenesis and biologic behavior of odontogenic tumors (OTs). Syndecan-1 is a heparan sulfate proteoglycan which has not been extensively investigated in these lesions. The objective of the present study was to assess the immunohistochemical expression of CD138 in adenomatoid odontogenic tumor (AOT), ameloblastic fibroma (AF) and odontogenic myxoma (OM) and to compare it with ameloblastoma and keratocystic odontogenic tumor (KCOT)...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28299276/unusually-large-sized-peripheral-ossifying-fibroma
#5
Reena Rachel John, Saravanan Kandasamy, Narendran Achuthan
Fibrous growths in the gingiva with the histopathological presence of calcifications are a common occurrence in the oral cavity. These lesions can be neoplastic in nature with either odontogenic or non odontogenic origin or they can be reactive lesions. This is a case report of an unusual presentation of peripheral ossifying fibroma , unusual because of its abnormally large size with review of literature.
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28292370/psammomatoid-juvenile-ossifying-fibroma-of-mandible-in-a-41-year-male-patient
#6
Betina Chandolia, Manas Bajpai
Juvenile ossifying fibroma (JOF) is a rare fibro-osseous neoplasm that develops among the craniofacial bones at an early age; and in majority of patients, it is diagnosed in the first or second decade of life. We present a case in 41-year male patient having it in the left anterior mandibular region. Peripheral eosinophilic areas resembling psammomatoid bodies along with other features impelled the diagnosis of psammomatoid ossifying fibroma. However, the term juvenile seems to be losing impact with the patients showing such features in old age...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28291396/mandibular-reconstruction-by-using-a-liquid-nitrogen-treated-autograft-in-a-dog-with-an-oral-tumor
#7
Yasuhiko Okamura, Kazuki Heishima, Tomoki Motegi, Jun Sasaki, Masanobu Goryo, Hideji Nishida, Hiroyuki Tsuchiya, Masaaki Katayama, Yuji Uzuka
A 10 yr old intact female German shepherd dog presented with a large peripheral odontogenic fibroma and malignant melanoma on her lower jaw. The tumor was resected with a unilateral subtotal rostral hemimandibulectomy. After the mandible was removed, it was devitalized intraoperatively by freezing it in liquid nitrogen. It was subsequently reimplanted. New bone tissue formed in the gap between the frozen bone and the host bone. The regenerated bone contained osteocytes, osteoblasts, and blood vessels. The cosmetic appearance of the dog was preserved...
March 14, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28289810/non-odontogenic-tumors-of-the-facial-bones-in-children-and-adolescents-role-of-multiparametric-imaging
#8
REVIEW
Minerva Becker, Salvatore Stefanelli, Anne-Laure Rougemont, Pierre Alexandre Poletti, Laura Merlini
Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of these lesions. Although rare, pediatric tumors arising in the facial bones comprise a wide spectrum of benign and malignant lesions of osteogenic, fibrogenic, hematopoietic, neurogenic, or epithelial origin...
March 13, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28289785/-incidental-findings-in-musculoskeletal-radiology
#9
F Wünnemann, C Rehnitz, M-A Weber
BACKGROUND: Increasing numbers of conventional X‑rays, computed tomography and magnetic resonance imaging in the inpatient, outpatient and scientific routine leads to an increasing number of incidental findings. The correct interpretation of these incidental findings with respect to the relevance and the evaluation concerning further work-up is an important task of radiologists. OBJECTIVE: Description of common incidental findings in musculoskeletal imaging and their clinical classification...
March 13, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28288139/mice-deleted-for-cell-division-cycle-73-gene-develop-parathyroid-and-uterine-tumours-model-for-the-hyperparathyroidism-jaw-tumour-syndrome
#10
G V Walls, M Stevenson, K E Lines, P J Newey, A A C Reed, M R Bowl, J Jeyabalan, B Harding, K J Bradley, S Manek, J Chen, P Wang, B O Williams, B T Teh, R V Thakker
The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malignant neoplasms. HPT-JT is caused by mutations of the cell division cycle 73 (CDC73) gene, located on chromosome 1q31.2 and encodes a 531 amino acid protein, parafibromin. To facilitate in vivo studies of Cdc73 in tumourigenesis we generated conventional (Cdc73(+/-)) and conditional parathyroid-specific (Cdc73(+/L)/PTH-Cre and Cdc73(L/L)/PTH-Cre) mouse models...
March 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28282537/a-large-solitary-fibroma-of-the-deep-compartment-of-the-sole
#11
T H Lui
A 50-year-old lady presented with a right foot mass and pain for 1year. Magnetic resonance imaging showed a 3.9×3.2×5cm mass on plantar side of the forefoot deep to the major flexor tendons and plantar aponeurosis and inferior to 1st-4th metatarsals. The mass extended dorsally through the intermetatarsal space to the foot dorsum. Ultrasound guided biopsy was performed, which confirmed it was a fibroma. This case was further complicated by pathological fracture of the 3rd metatarsal. It was resected through a dorsal incision and surgical dislocation of the 2nd and 3rd tarsometatarsal joints...
December 7, 2016: Foot
https://www.readbyqxmd.com/read/28272664/desmoplastic-fibroblastoma-in-maxillary-alveolar-bone-mimicking-an-odontogenic-lesion-a-novel-case-report-with-review-of-literature
#12
Zohreh Jaafari-Ashkavandi, Mehdi Yasamin Shirazi, Sepideh Assar
Desmoplastic fibroblastoma (Collagenous fibroma) is a rare benign soft tissue tumor that disseminates widely and can be intramuscular or subcutaneously. There are seven reported cases in the oral cavity so far. We reported a novel case of collagenous fibroma that has been found in the anterior part of maxilla in a 58-year-old woman as an intraosseous radiolucent lesion that has been discovered during routine radiography. Histopathologically, spindle and stellate-shaped fibroblasts in a collagen-rich stroma as well as binucleated and multinucleated fibroblasts with prominent nucleoli were seen...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28266050/cutaneous-dermal-non-neural-granular-cell-tumor-is-a-granular-cell-dermal-root-sheath-fibroma
#13
Angel Fernandez-Flores, David S Cassarino, Erica Riveiro-Falkenbach, José Luis Rodriguez-Peralto, Maria Teresa Fernandez-Figueras, Carlos Monteagudo
Dermal non-neural granular cell tumor (NNGCT) was first described in 1991 as an S100-negative polypoid non-melanocytic tumor. Although originally introduced in the literature as a primary cutaneous tumor, it was later emphasized that such qualification could not be held until the line of differentiation was clarified. It was also demonstrated that not all cases were polypoid. In the current study we try to further characterize this entity by presenting five cases of NNGCT. As expected, not all of them were polypoid...
March 7, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28255973/chondromyxoid-fibroma-of-the-skull-base-our-experience-with-an-elusive-disease
#14
Giancarlo D'Andrea, Alessandro Pesce, Guido Trasimeni, Venceslao Wierzbicki, Veronica Picotti, Alessandra Serraino, Riccardo Caruso
Chondromyxoid fibroma (CMF) is an extremely rare lesion of the skull base. This histologic type typically predilects metaphysis of the long bones. It is locally invasive/infiltrative, and this tendency is more concerning in the skull base, where a radical resection is often technically impossible because of the presence of vital neurovascular structures. We present a case of a 19-year-old woman who presented with a sudden onset of right facial weakness, progressively worsening to a severe disfiguring motor weakness...
March 2, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28252593/-the-recurrent-laryngeal-fibroma
#15
V M Svistushkin, S V Starostina, E B Rakunova
No abstract text is available yet for this article.
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28252420/metaphyseal-cortical-defect-and-tumor-like-processes-of-long-bones-a-literature-review-and-own-observations
#16
N Lysenko, Ye Sharmazanova, I Voronzhev, A Sorochan, Yu Kolomiychenko
Metaphyseal cortical defect (metaphyseal fibrous defect, cortical fibrous defect) of the long bones is a quite common variant of the bone structure's pathologic changes. The cortical defects and similar to their tumor-like processes (non-ossifying fibroma, benign fibrous histiocytoma etc.) are characterized by particular qualities of the clinical symptoms and radiologic signs. The aim of this article is to analyze a known literature data about cortical fibrous defects of long bones and similar to their tumor-like processes and present results of our own observations...
January 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28250723/ulipristal-acetate-before-high-complexity-endoscopic-hysteroscopic-laparoscopic-myomectomy-a-mini-review
#17
REVIEW
Włodzimierz Baranowski
Uterine myomas (fibromas, leiomyomas) are the most common tumours in women, and their clinical signs and symptoms are presented by 25-40% of patients with these benign tumours. According to current guidelines, the armamentarium for myoma management consists of: medical therapy (GnRH, SPRMs), non-surgical alternatives including uterine artery embolisation (UAE), vaginal temporary occlusion of uterine arteries using clamp-like device or MRgFUS technique, and surgical treatment (including minimally invasive techniques)...
December 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28246495/accuracy-of-transvaginal-ultrasonography-compared-to-endometrial-biopsy-for-the-etiological-diagnosis-of-abnormal-perimenopausal-bleeding
#18
Renata Nicula, Doru Diculescu, Codruţa Claudia Lencu, Răzvan Ciortea, Carmen Elena Bucuri, Ioana Adriana Oltean, Ioana Alexandra Trif, Dan Mihu
BACKGROUND AND AIMS: Perimenopause is marked by clinical manifestations which disturb everyday life and which may also hide a pathomorphological, more precisely endometrial, substrate. An accurate early diagnosis established by accessible, non-invasive methods is very important for the therapeutic management. METHOD: The study included 103 patients aged between 41.5-55.11 years, divided into 3 age groups: 40-44 years (n=10), 45-49 years (n=54) and ≥50 years (n=39)...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28245242/assessing-and-managing-wounds-of-buruli-ulcer-patients-at-the-primary-and-secondary-health-care-levels-in-ghana
#19
Naa Okaikor Addison, Stefanie Pfau, Eric Koka, Samuel Yaw Aboagye, Grace Kpeli, Gerd Pluschke, Dorothy Yeboah-Manu, Thomas Junghanss
BACKGROUND: Beyond Mycobacterium ulcerans-specific therapy, sound general wound management is required for successful management of Buruli ulcer (BU) patients which places them among the large and diverse group of patients in poor countries with a broken skin barrier. METHODS: Clinically BU suspicious patients were enrolled between October 2013 and August 2015 at a primary health care (PHC) center and a municipal hospital, secondary health care (SHC) center in Ghana...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28235628/denosumab-treated-giant-cell-tumor-of-bone-its-histologic-spectrum-and-potential-diagnostic-pitfalls
#20
Pablo Daniel Roitman, Federico Jauk, Germán Luis Farfalli, José Ignacio Albergo, Luis Alberto Aponte-Tinao
Giant cell tumor of bone (GCT) is a locally aggressive, rarely metastasizing primary bone neoplasm that occurs most frequently in the epiphysis of long bones of young adults. It is composed of round, oval or elongated mononuclear cells admixed with osteoclast-like giant cells that express receptor activator of nuclear factor- қB (RANK). The mononuclear stromal cells express RANK ligand (RANKL), a mediator of osteoclast activation. Denosumab, a monoclonal antibody that inhibits RANKL reducing tumor-associated bone lysis, has been used to treat selected cases of GCT...
February 21, 2017: Human Pathology
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