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https://www.readbyqxmd.com/read/29152441/trabecular-variant-juvenile-ossifying-fibroma-of-the-maxilla
#1
Ashwan Paranthaman, Vandana Shenoy, Senthil Kumar, Laavanya Marimuthu, Sakthivel Velusubbiah, Shonali Vijayaraj
Juvenile ossifying fibroma (JOF) is a benign, bone-forming neoplasm occurring primarily in children and adolescents. JOF is an aggressive variant of ossifying fibroma of the jaw with a variable clinical behavior and a high tendency for recurrence. Early detection and prompt treatment are required to treat JOF successfully. This case report describes JOF in a 13-year-old girl presenting with a year-long, gradually progressive swelling on the right side of her face with typical clinical, radiological, and histopathological features...
September 14, 2017: Curēus
https://www.readbyqxmd.com/read/29151945/clinicopathological-characteristics-and-prognosis-of-ossifying-fibroma-in-the-jaws-of-children-a-retrospective-study
#2
Ying Liu, Xiao-Feng Shan, Xue-Sheng Guo, Shang Xie, Zhi-Gang Cai
BACKGROUND: Ossifying fibroma in the jaws is a benign tumor and easily recurs in children, of which the treatment methods and prognosis still remain controversial. In this study, we aimed to review the clinicopathological characteristics, treatment, and prognosis of ossifying fibroma in the jaws of children, and offer recommendations for clinical decision-making. METHODS: A retrospective study was carried out on patients below the age of 18 years with ossifying fibroma in the jaws. Patients with complete clinical, pathological, and radiological records were included and followed-up...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29140884/ovarian-sex-cord-stromal-tumors-with-melanin-pigment-report-of-a-previously-undescribed-phenomenon
#3
Jennifer Taylor, W Glenn McCluggage
We report 2 ovarian sex cord-stromal tumors, a luteinized adult granulosa cell tumor and a cellular fibroma, with melanin pigment. These occurred in 44 and 61-yr-old patients, respectively. As far as we are aware, melanin pigment has not been described previously in an ovarian sex cord-stromal tumor, although it has been reported in a testicular Sertoli cell tumor. We review ovarian neoplasms containing melanin pigment.
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29132723/ovarian-sex-cord-stromal-tumours-and-their-mimics
#4
REVIEW
Robert H Young
Sex cord-stromal tumours of the ovary include many of the most morphologically intriguing ovarian neoplasms and albeit many of them are rare, they factor into the differential diagnosis more often than their frequency might suggest. The most common malignant form, the adult granulosa cell tumour, may grossly simulate various surface epithelial neoplasms. Microscopically, confusion with endometrioid carcinoma may occur because the cords and microfollicles of the granulosa cell tumour may be mimicked by endometrioid carcinoma and the latter may have pale nuclei with nuclear grooves...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29112653/long-term-results-for-expectant-management-of-ultrasonographically-diagnosed-benign-ovarian-teratomas
#5
M Angela Pascual, Betlem Graupera, Cristina Pedrero, Ignacio Rodriguez, Silvia Ajossa, Stefano Guerriero, Juan Luis Alcázar
OBJECTIVE: To assess the natural history of ultrasonographically diagnosed benign ovarian teratomas in asymptomatic women. METHODS: We conducted a retrospective observational cohort study of 408 women (mean age 36.6 years, range 14-81 years) diagnosed as having an ovarian teratoma by transvaginal ultrasonography (except eight who only had a transabdominal study done) between January 2003 and December 2013 at a single tertiary care institution. Six hundred thirteen women were diagnosed with ovarian teratoma of whom 205 were promptly treated surgically, leaving 408 patients followed conservatively with follow-up scans at 3 and 6 months from diagnosis and then yearly...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29110035/-new-aspects-on-giant-cell-tumor-of-bone
#6
REVIEW
J Lüke, M Hasenfratz, P Möller, T F E Barth
A giant cell tumor of bone (GCTB) is one of the giant cell-rich lesions of bone and has to be differentiated from non-ossifying fibroma, aneurysmatic bone cyst, chondroblastoma, "brown tumor" and osteosarcoma containing giant cells. A hallmark of GCTB is the presence of the distinct histone 3 (H3F3A) mutation G34W and its detection either by sequencing methods or using immunohistochemistry with a novel antibody against this mutational site. Worrisome is the fact that under denosumab therapy a histological change of the lesions can be seen and there are first reports of sarcomas arising after therapy...
November 6, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29109321/epidemiological-and-clinicopathological-analysis-of-92-odontogenic-tumors-a-5-year-retrospective-study
#7
Ipsita Sharma, Deepa Venkatesh, Geetanjali Bawa, Syed Vaseemuddin, Amit Joseph, Jimmy K Sangtani
INTRODUCTION: Odontogenic tumors (OTs) are a heterogeneous group of lesions that are derived from odontogenic apparatus comprised of odontogenic epithelium, ectomesenchyme, and/ or mesenchymal elements. The OTs show marked geographical variation. This study was conducted to analyze the epidemiology and clinicopathological presentation of OTs based on age, sex, and site. MATERIALS AND METHODS: This study was conducted in Department of Oral Pathology and Microbiology...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29106748/solitary-fibrous-tumor-of-the-female-genital-tract-a-clinicopathologic-analysis-of-25-cases
#8
Eric J Yang, Brooke E Howitt, Christopher Dm Fletcher, Marisa R Nucci
AIMS: Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm of fibroblastic origin, first described as a tumor of the pleura and now well established at extrapleural sites. However, SFT in the female genital tract is rare and therefore not fully characterized. MATERIAL AND RESULTS: We describe a series of 25 SFTs arising throughout the gynecologic tract, including vulva (14 cases), vagina (1), cervix (1), uterus (6), ovary (2) and fallopian tube (1)...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29099370/metachronous-ameloblastic-fibro-odontoma-and-dentigerous-cyst-in-the-posterior-mandible
#9
Mário Rodrigues de Melo Filho, Sabina Pena Borges Pêgo, Claudio Marcelo Cardoso, Breno Amaral Rocha, Hercílio Martelli-Júnior, Isadora Luana Flores, Luis Antônio Nogueira Dos Santos, Livia Máris Ribeiro Paranaiba
An ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor with histologic features of an ameloblastic fibroma in conjunction with the presence of dentin and enamel. It usually appears as a well-circumscribed radiolucency with radiopaque foci and slow growth and is commonly seen in children and young adults. A 13-year-old boy presented with an asymptomatic swelling in the posterior right region of the mandible and the right ascending ramus. The clinical, imaging, and histopathologic findings confirmed the diagnosis of an AFO...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29090469/multiple-epidermolytic-acanthomas-mimicking-condyloma-a-retrospective-study-of-8-cases
#10
Tsung-Ju Lee, Yu-Hung Wu
BACKGROUND: Epidermolytic acanthoma (EA) is an uncommon benign cutaneous lesion. Multiple epidermolytic acanthomas (multiple EAs) are rarely reported. METHODS: We retrospectively identified patients diagnosed with multiple EAs between 2005 and 2017 from our dermatopathology database and analyzed their clinical, pathological, and immunohistochemical features. We also evaluated the association of multiple EAs with human papillomavirus (HPV) infection. RESULTS: In total, eight patients (average age 51 years; 3 : 1 male predominance) with multiple EAs were found...
October 31, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29081852/the-aetiology-of-the-non-ossifying-fibroma-of-the-distal-femur-and-its-relationship-to-the-surrounding-soft-tissues
#11
A Goldin, D A Muzykewicz, J Dwek, S J Mubarak
PURPOSE: We aim to retrospectively evaluate patients with non-ossifying fibroma (NOF) of the distal femur by radiographs, CT and MRI, and to provide a theory describing the reasoning for the distal femur NOF's location and aetiology. METHODS: Charts of patients with NOFs between 2003 and 2014 were retrospectively reviewed. Inclusion criteria encompassed a diagnosis of NOF of the distal femur by imaging, and histologically, if available. Radiographs, CT and MRI were used to characterise the relationship of the NOF lesions with the surrounding soft tissues...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29079239/osteochondroma-of-the-cuboid-a-case-report
#12
Jeffrey M Whitaker, Grace C Craig, Sadie Winship
Osteochondromas are common benign exostoses with <1% of pedal occurrences. Several cases of osteochondromas have been previously reported in the foot and ankle but none from the cuboid. In the present study, we report a case of osteochondroma originating from the cuboid in a 29-year-old male patient. The patient presented with an aching and shooting pain to his left foot that had progressed during the course of 3 years. Originally diagnosed as a fibroma, the patient had undergone cortisone injections that did not help with his symptoms...
November 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29074442/conservative-management-of-an-atypical-intra-sinusal-ossifying-fibroma-associated-to-an-aneurysmal-bone-cyst
#13
R Saad, J-C Lutz, S Riehm, L Marcellin, C-I Gros, F Bornert
Ossifying fibroma (OF) is a benign fibro-osseous lesion mainly occurring in young adults and seems to originate from the periodontal ligament. Aneurysmal bone cyst (ABC) is a benign intraosseous lesion characterized by blood-filled spaces of various sizes. These two lesions can specifically affect the jaws and are commonly described in the literature. However, few cases describing an association of OF and ABC have been reported in the literature, especially in the maxillary sinus. We report the case of a 40-year-old male patient affected with an asymptomatic lesion with a dual component of OF and ABC laying in the maxillary sinus...
October 24, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29068068/late-stage-nodular-erythema-elevatum-diutinum-mimicking-sclerotic-fibroma
#14
Kevin Y Shi, Travis Vandergriff
Erythema elevatum diutinum (EED) is a rare, cutaneous vasculitis of uncertain origins. EED can present clinically as chronic bilateral, symmetrical, periarticular papules, plaques, and nodules. We report here an unusual case of EED presenting as multiple, densely fibrosing nodules on the feet of a 60 year-old HIV positive woman. The initial evaluation of the patient was complicated by the strong histologic resemblance of multiple lesions to sclerotic fibroma (SF), a cutaneous manifestation of Cowden disease...
October 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29067964/reconstruction-of-tibial-nonossifying-fibroma-accompanying-with-undetected-ewing-s-sarcoma-by-ilizarov-method
#15
Xue-Hui Liu, Ge Sun, Chang-Gui Tong, Zhi-Hong Tong, Hai-Dong Liang
No abstract text is available yet for this article.
November 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29062253/gorlin-goltz-syndrome
#16
Betül Şereflican, Bengü Tuman, Murat Şereflican, Sıddıka Halıcıoğlu, Gülzade Özyalvaçlı, Seval Bayrak
Gorlin-Goltz syndrome is a rare multisystemic disease inherited in an autosomal dominant pattern. It is characterized by numerous basal cell carcinoma of the skin, jaw cysts, and skeletal anomalies such as frontal bossing, vertebral anomalies, palmoplantar pits, and falx cerebri calcification. There is a tendency to tumors including medullablastoma, fibroma, rabdomyoma, leiomyosarcoma etc.. The diagnosis is based on major and minor clinical and radiologic criteria. Early diagnosis and treatment are of utmost importance in reducing the severity of long-term sequelae of this syndrome...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29049491/dermal-hyperneury-and-multiple-sclerotic-fibromas-in-multiple-endocrine-neoplasia-type-2a-syndrome
#17
Victoria Alegría-Landa, Margarita Jo-Velasco, Mercedes Robledo, Luis Requena
Importance: Multiple endocrine neoplasia type 2 (MEN 2) syndrome is an autosomal dominant, hereditary cancer disorder caused by germline mutations in the RET (formerly MEN2A, MEN2B) proto-oncogene located on chromosomal band 10q11.21. Two distinct clinical forms have been described as the following phenotypes: multiple endocrine neoplasia type 2A (MEN 2A) and multiple endocrine neoplasia type 2B (MEN 2B) syndromes. The common and necessary nexus that defines these 2 phenotypes is the presence of medullary thyroid carcinoma (MTC)...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29040582/cdc73-related-disorders-clinical-manifestations-and-case-detection-in-primary-hyperparathyroidism
#18
Karin van der Tuin, Carli M J Tops, Muriel A Adank, Jan-Maarten Cobben, Neveen A T Hamdy, Marjolijn C Jongmans, Fred H Menko, Bernadette P M van Nesselrooij, Romana T Netea-Maier, Jan C Oosterwijk, Gerlof D Valk, Bruce H R Wolffenbuttel, Frederik J Hes, Hans Morreau
Context: Heterozygous pathogenic germline variants in CDC73 predispose to the development of primary hyperparathyroidism (pHPT), and less frequently, ossifying fibroma of the jaw and renal and uterine tumors. Clinical information on CDC73-related disorders has so far been limited to small case series. Objective: To assess the clinical manifestations and penetrance in CDC73-related disorders and to improve case detection in pHPT. Design: Nationwide retrospective Dutch cohort study...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29039452/molecular-analysis-of-keratocystic-odontogenic-tumor-cell-lines-derived-from-sporadic-and-basal-cell-nevus-syndrome-patients
#19
Kazuma Noguchi, Keiko Wakai, Tohru Kiyono, Mutsuki Kawabe, Kyohei Yoshikawa, Tomoko Hashimoto-Tamaoki, Hiromitsu Kishimoto, Yoshiro Nakano
Keratocystic odontogenic tumor (KCOT) is a benign tumor often associated with basal cell nevus syndrome (BCNS). Mutations in Patched 1 (PTCH1), the Hedgehog (Hh) receptor, are responsible for BCNS. BCNS is distinguished by morphological anomalies and predisposition to benign and malignant tumors, including medulloblastoma, basal cell carcinoma, KCOT and ovarian fibromas. Among these tumors, KCOT is the least well studied because a suitable model system is not available for its investigation. To enable KCOT to be studied, we established two KCOT cell lines, one from a BCNS case (designated as iKCOT1) and one from a sporadic KCOT case (designated as sKCOT1)...
October 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29032608/microrna-profiling-reveals-dysregulated-micrornas-and-their-target-gene-regulatory-networks-in-cemento-ossifying-fibroma
#20
Thaís Dos Santos Fontes Pereira, João Artur Ricieri Brito, André Luiz Sena Guimarães, Carolina Cavaliéri Gomes, Júlio Cesar Tanos de Lacerda, Wagner Henriques de Castro, Roney Santos Coimbra, Marina Gonçalves Diniz, Ricardo Santiago Gomez
BACKGROUND: Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis, and its treatment results in morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis...
October 15, 2017: Journal of Oral Pathology & Medicine
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