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Mona Ebadian, Luigi Citarella, Damian Collins, Salvador Diaz-Cano, Lucia Pozo-Garcia
The dermoscopic features of solitary storiform collagenomas (sclerotic fibromas) have not been described previously, as these are rare cutaneous soft tissue tumors. The presence of multiple lesions is considered a marker of Cowden syndrome. They can also present as single firm cutaneous nodules. We present an unusual single nodule with distinct dermoscopic and histologic features.
April 2018: Dermatology Practical & Conceptual
Mirjana Bakić, Marina Ratković, Branka Gledović, Balsa Vujović, Danilo Radunović, Vera Babić, Vladimir Prelević
Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). There are two different genetic loci responsible for TS: 9q34 (TSC1-hamartin) and 16p13...
April 2018: Acta Dermatovenerologica Croatica: ADC
S S Padala, M A Kiresur, A Ananthaneni, V S Guduru, H K Puneeth, B Bhavana
Toto bodies are eosinophilic structures that resemble the cells of the superficial cell layer of the oral epithelium. Toto bodies commonly are associated with inflammatory gingival and other mucosal lesions including pyogenic granuloma, irritational fibroma, epulis fissuratum, peripheral giant cell granuloma and inflammatory hyperplastic gingivitis. We evaluated staining characteristics of Toto bodies to establish their origin and to identify their significance in lesions. We investigated pyogenic granuloma, fibroma and leukoplakia with epithelium that exhibited Toto bodies after hematoxylin and eosin (staining...
May 21, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
JoonGoon Kim, MoonHyung You, YeonWoong Kim, DongHoon Shin, JongSoo Choi
No abstract text is available yet for this article.
May 20, 2018: Breast Journal
Do-Youn Kim, Oh Hyeong Lee, Gyeong Cheol Choi, Jin Hee Cho
Juvenile psammomatoid ossifying fibroma (JPOF) is a rare tumor that occurs in maxillary sinus or orbit. Complete removal is required due to the aggressive and locally destructive nature. It is hard to distinguish from psammomatoid meningioma in cranial lesion and to remove completely. The authors are presenting a case of 26-year-old male with JPOF on skull base and report this case with review of literature.
May 14, 2018: Journal of Craniofacial Surgery
Jing Ju, Nan Wang, Jiali Wang, Fanrong Wu, Jinfang Ge, Feihu Chen
Background: 4-Amino-2-trifluoromethyl-phenyl retinate (ATPR), a novel retinoid derivative, inhibits proliferation and induces differentiation in many cancer cells. In this study, the inhibitory effects of ATPR on the proliferation, invasion, and migration of breast cancer (BC) cells, and the relationship between ATPR and the expression of the intracellular lipid-binding proteins CRABP2 and FABP5 were investigated. Methods: CRABP2 and FABP5 expression was evaluated in infiltrating breast-infiltrating ductal carcinoma(BIDC) and benign breast fibroma (BBF) by immunohistochemistry and in MCF-7, MDA-MB-231, MDA-MB-435, and MDA-MB-453 cells by immunofluorescence...
2018: Drug Design, Development and Therapy
Amir Ala Aghbali, Ayshin Akbarzadeh, Maryam Kouhsoltani
Background: Many studies have reported that macrophages and eosinophils are involved in the pathogenesis of several diseases. To the best of our knowledge, this is the first study comparing macrophages and eosinophils in oral reactive lesions. Aims: In this study, we aimed to determine the contribution of macrophages and eosinophils to the pathogenesis of oral reactive lesions and the relationships between these biomarkers and the diverse histopathologic features...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Kamile Leonardi Dutra, Lunardo Longo, Liliane Janete Grando, Elena Riet Correa Rivero
INTRODUCTION: Reactive hyperplastic lesions develop in response to a chronic injury simulating an exuberant tissue repair response. They represent some of the most common oral lesions including inflammatory fibrous hyperplasia, oral pyogenic granuloma, giant cell fibroma, peripheral ossifying fibroma, and peripheral giant cell lesions. OBJECTIVE: The incidence of those lesions was investigated in an oral pathology service, and the clinical characteristics, associated etiological factors, concordance between the clinical and histopathological diagnostic was determined...
April 17, 2018: Brazilian Journal of Otorhinolaryngology
Tanjala T Gipson
BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results in tumor growth in various organs. TSC can affect the kidneys in the form of renal angiomyolipomas and cysts that can lead to chronic kidney disease. CASE PRESENTATION: A 38-year-old woman was referred to Kennedy Krieger Institute for comprehensive TSC management. Before referral, the patient had gone most of her life without a definite diagnosis of TSC despite visually-prominent signs such as forehead plaques, facial angiofibromas, and ungual fibromas...
April 27, 2018: Clinical Nephrology
Jong Woong Park, Hyun Guy Kang, Kwun Mook Lim, June Hyuk Kim, Han Soo Kim
CASE: A 23-year-old soldier was diagnosed with a calcaneal desmoplastic fibroma. Limb-salvage surgery using a 3-dimensionally (3D) printed personalized implant made from a titanium alloy was planned. The implant had a mesh-style surface for free tendon suture, and the joint surface was smooth to preserve the subtalar joint. The implant had 3 hollow posts in case of future transarticular immobilization. At the last follow-up, the implant was painless and stable, and the patient could walk normally without support...
April 25, 2018: JBJS Case Connector
Anjali Mathur, Ankit Seth, Leela Pant
Ovarian fibroma with minor sex cord element (MSCE) is a rare tumor. The increased estrogen production due to the presence of MSCE and/or luteinized thecal cells within fibroma can be a risk factor for endometrial hyperplasia or carcinoma.
April 2018: Indian Journal of Pathology & Microbiology
Akshay Gopinathan Nair, Hemal Kenia, Indumati Gopinathan, Siddharth V Mehta, Vinod C Mehta
A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in "feather-stitched" or storiform pattern were seen. Immunohistochemically, the cells stained negatively for CD-34 and S-100 and focal positivity was seen for vimentin. Based on the morphology and immunochemical staining, a diagnosis of corneal fibroma was made...
May 2018: Indian Journal of Ophthalmology
Shilpa Rao, Bevinahalli N Nandeesh, Arimappamagan Arivazhagan, Aliasgar V Moiyadi, T Chickabasaviah Yasha
Psammomatoid juvenile ossifying fibroma (PJOF), a variant of juvenile ossifying fibroma (JOF), is a locally aggressive neoplasm of the children and young adults. This entity has predilection for the sinonasal region. It forms a differential diagnosis for many bone neoplasms. We report three cases of PJOF, in young patients whose biopsy showed the presence of psammomatoid bodies in a cellular fibrous stroma. The diagnosis of JOF indicates requirement of extensive surgery due to its locally aggressive nature.
October 2017: Journal of Pediatric Neurosciences
Ana-Carolina Vasconcelos, Ana-Paula Gomes, Sandra Tarquinio, Eduardo Abduch-Rodrigues, Ricardo Mesquita, Karine Silva
Collagenous fibroma, also known as desmoplastic fibroblastoma, is a rare benign slow growing tumor particularly uncommon in the oral cavity. The aim of this study was to analyze the clinical and histopathological features of an oral collagenous fibroma as well as to compare this data with those reported in an English-literature review. The thirteenth case of collagenous fibroma in the oral cavity and the first to present clinically as a bilateral mass was described. A 48-years-old female patient was referred to a School of Dentistry, complaining about an asymptomatic swelling on the hard palate, lasting around ten years...
January 2018: Journal of Clinical and Experimental Dentistry
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, Sung Won Kim
OBJECTIVE: To examine the utility of an endoscopic transseptal approach and the creation of a bilateral nasoseptal flap using a two-nostrils/four-hands technique in patients with challenging skull-base tumors. METHODS: The medical records of patients operated on via an endoscopic transseptal approach between 2009 and 2017 were retrospectively reviewed. Two patients with ossifying fibroma, two with orbital hemangioma, two with trigeminal nerve schwannoma, and one patient each with juvenile angiofibroma, meningioma, and myxofibrosarcoma were included in the study...
April 9, 2018: World Neurosurgery
Naba Pallab Chetia, Aritra Bidyananda, Munin Borgohain
Chondromyxoid fibroma is a benign bone tumour accounting for less than 1% of all primary bone tumours. It usually affects the metaphyseal region of long bones in the first or second decade of life. It rarely occurs in scapula. We present a case of 29 year old female with biopsy proven Chondromyxoid fibroma of left scapula. She underwent wide marginal excision by partial scapulectomy with preservation of glenoid. Post operatively she has stable shoulder joint with normal range of movement & no recurrence on regular follow up...
March 2018: Journal of Clinical Orthopaedics and Trauma
Blake E Cohen, Naveen S Murthy, Gavin A McKenzie
The purpose of this series is to review the appearance of plantar fibromatosis with high-resolution ultrasonography (US) and highlight a new imaging sign termed the "comb sign." A retrospective study was performed for patients with a clinical diagnosis of plantar fibromatosis. Charts of 43 patients (age range, 26-77 years; mean age, 54 years) were reviewed to gather patient demographics and symptoms. Several US characteristics were evaluated with emphasis on any new imaging features. A total of 57 plantar fibromas in 43 patients were examined...
March 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Kamil M Amer, Sana Mohamed, Rami Amer, Ahmed Chaudhry, Brian Winters, John A Abraham
Although certainly not the first line treatment for plantar fibromas, surgical resection is a treatment option for some patients with have failed exhaustive non-surgical treatment. The use of topical Mitomycin C has been recently shown to reduce the recurrence rate of other fibrous lesions. The purpose of this study was to determine the impact of topical application of Mitomycin C on recurrence rate of plantar fibromas. A retrospective analysis was done from a prospectively gathered database with a total 50 consecutive patients over a 16-month study period...
March 30, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Masaya Kawaguchi, Hiroki Kato, Tatsuhiko Miyazaki, Keizo Kato, Daijiro Hatakeyama, Keisuke Mizuta, Mitsuhiro Aoki, Masayuki Matsuo
OBJECTIVES: The current study aimed to assess CT and MRI characteristics of histological subtypes of head and neck ossifying fibroma (OF). METHODS: 12 patients with histopathologically-proven head and neck OF were included in this study. Lesions were pathologically classified into three histological subtypes: eight cement-OFs (COFs), three juvenile psammomatoid OFs (JPOFs), and one juvenile trabecular OF (JTOF). All patients underwent CT examination, while seven also underwent MRI...
April 11, 2018: Dento Maxillo Facial Radiology
Nicolas Macagno, Kevin Caselles, Sébastien Aubert, Virginie Audard, Anne Gomez-Brouchet, Christine Galant, Jean-Marc Guinebretière, Marie Karanian, Frédérique Larousserie, Béatrice Marie, Gonzague de Pinieux, Corinne Bouvier
The infiltration by numerous osteoclastic giant cells is a frequent finding in bone tumors and pseudo-tumors. Pathologists must integrate clinical and radiological data to achieve a correct diagnosis in bone pathology. Benign giant-cell rich lesions of bone encompass giant cell tumor of bone, aneurysmal bone cyst, chondroblastoma, brown tumor and fibrous cortical defect/non-ossifying fibroma. Amongst malignant neoplasms, variants of conventional osteosarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma and bone metastasis must be discussed...
March 23, 2018: Annales de Pathologie
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