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https://www.readbyqxmd.com/read/27922234/long-term-azithromycin-therapy-in-patients-with-cystic-fibrosis
#1
Nagehan Emiralioğlu, Zeynelabidin Öztürk, Ebru Yalçın, Deniz Doğru, Uğur Özçelik, Nural Kiper
Inflammation is a central contributor to the pathogenesis of cystic fibrosis (CF) pulmonary disease; so limiting the excessive production of inflammatory mediators represents a major therapeutic strategy for slowing the decline in lung function and improving survival. The macrolide antibiotic azithromycin (AZM) has anti-inflammatory properties and immunomodulatory effects that may be beneficial in CF. The aim of this study was to document the long term use of AZM effect on pulmonary function, nutritional status and number of pulmonary exacerbations in patients with CF...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27870227/aspergillosis-and-the-role-of-mucins-in-cystic-fibrosis
#2
REVIEW
Abigail C Cowley, David J Thornton, David W Denning, Alexander Horsley
The prevalence of aspergillosis in CF patients has until recently been underestimated, but increasing evidence suggests that it may play an important role in the progression of CF lung disease. In healthy airways, Aspergillus fumigatus can be efficiently removed from the lung by mechanisms such as mucociliary clearance and cough. However, these mechanisms are defective in CF, allowing pathogens such as A. fumigatus to germinate and establish chronic infections within the airways. The precise means by which A...
November 21, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27740723/respiratory-syncytial-virus-hospitalization-and-mortality-systematic-review-and-meta-analysis
#3
Renato T Stein, Louis J Bont, Heather Zar, Fernando P Polack, Caroline Park, Ami Claxton, Gerald Borok, Yekaterina Butylkova, Colleen Wegzyn
BACKGROUND: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. METHODS: Systematic literature review and meta-analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV-ARI and death. RESULTS: Five thousand two hundred and seventy-four references were identified...
October 14, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27735179/pediatric-pulmonology
#4
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Clinical Privilege White Paper
https://www.readbyqxmd.com/read/27717243/differences-in-gene-mutations-between-chinese-and-caucasian-cystic-fibrosis-patients
#5
Baoying Zheng, Ling Cao
Cystic fibrosis (CF) is rarely seen in Asian populations. We diagnosed two CF cases. One of them had a novel mutation c.870-1G>C in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. There have been 38 Chinese CF patients reported in literature from 1974 until the present (2016), 25 different mutations were identified. Only one of these mutations (R553X) is in the Caucasian CF screening panel. The mutations identified in Chinese CF patients are very different from the common Caucasian gene mutations...
October 7, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27583409/new-guidelines-for-managing-pulmonary-hypertension-what-the-pediatrician-needs-to-know
#6
Steven H Abman
PURPOSE OF REVIEW: Pediatric pulmonary vascular disease contributes to morbidities and death in diverse clinical settings, ranging from idiopathic or heritable forms of pediatric arterial hypertension, congenital heart disease, developmental lung disorders, chronic lung disease, left heart disease, sickle cell disease, oncologic disease, and systemic disorders. Despite its impact on the clinical courses in so many diseases, information is limited on how to best approach the diagnosis and evaluation of pediatric pulmonary hypertension...
October 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27566421/progress-in-pediatrics-in-2015-choices-in-allergy-endocrinology-gastroenterology-genetics-haematology-infectious-diseases-neonatology-nephrology-neurology-nutrition-oncology-and-pulmonology
#7
EDITORIAL
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Virginia Mirra, Sergio Bernasconi
This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature...
August 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27451588/respiratory-tuberculosis-in-children-and-adolescents-assessment-of-radiological-severity-pattern-and-age-related-changes-within-two-decades
#8
Maria T A Buzan, Carmen Monica Pop, Mihaela Raduta, Monika Eichinger, Claus Peter Heussel
INTRODUCTION: Despite the global decline of tuberculosis (TB), the annual risk of TB infection in children from developing countries remains high. Giving the global and regional epidemiological context in the past 20 years and a recent classification, dividing childhood TB into severe and non-severe disease, our aim was to find possible differences regarding disease severity in the pediatric population, as assessed by chest radiography (CXR) over 2 decades. MATERIALS AND METHOD: A retrospective analysis of CXRs from newly confirmed respiratory TB patients was performed at the Pediatric Pulmonology Department of a tertiary-care university hospital that acts as a referral TB center in Transylvania...
October 2015: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/27434480/management-of-obstructive-sleep-apnea-in-children-a-practical-approach
#9
Kevin D Pereira, Cindy K Jon, Peter Szmuk, Rande H Lazar, Ron B Mitchell
The management of sleep disordered breathing (SDB) in children differs between institutions, and there is a need for an updated review of current practice. Literature was reviewed using the PubMed database from 1995 to 2015 by four tertiary care providers experienced in the management of children with SDB. Articles were selected for clinical applicability, strength of evidence, and practicality for practicing clinicians. Fifty-five articles were identified by tertiary care providers in pediatric anesthesiology, pediatric pulmonology, sleep medicine, and pediatric otolaryngology...
July 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27383929/evaluating-bronchodilator-response-in-pediatric-patients-with-post-infectious-bronchiolitis-obliterans-use-of-different-criteria-for-identifying-airway-reversibility
#10
Rita Mattiello, Paula Cristina Vidal, Edgar Enrique Sarria, Paulo Márcio Pitrez, Renato Tetelbom Stein, Helena Teresinha Mocelin, Gilberto Bueno Fischer, Marcus Herbert Jones, Leonardo Araújo Pinto
OBJECTIVE: Post-infectious bronchiolitis obliterans (PIBO) is a clinical entity that has been classified as constrictive, fixed obstruction of the lumen by fibrotic tissue. However, recent studies using impulse oscillometry have reported bronchodilator responses in PIBO patients. The objective of this study was to evaluate bronchodilator responses in pediatric PIBO patients, comparing different criteria to define the response. METHODS: We evaluated pediatric patients diagnosed with PIBO and treated at one of two pediatric pulmonology outpatient clinics in the city of Porto Alegre, Brazil...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27370268/diagnosis-and-management-of-asthma-statement-on-the-2015-gina-guidelines
#11
Fritz Horak, Daniel Doberer, Ernst Eber, Elisabeth Horak, Wolfgang Pohl, Josef Riedler, Zsolt Szépfalusi, Felix Wantke, Angela Zacharasiewicz, Michael Studnicka
This statement was written by a group of pulmonologists and pediatric pulmonologists belonging to the corresponding professional associations ÖGP (Austrian Society for Pulmonology) and ÖGKJ (Austrian Society for pediatric and adolescent medicine) to provide a concise overview of the latest updates in the 2015 GINA Guidelines and to include aspects that are specific to Austria.
August 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27311742/the-success-of-the-different-eradication-therapy-regimens-for-pseudomonas-aeruginosa-in-cystic-fibrosis
#12
N Emiralioglu, E Yalcin, A Meral, B Sener, D Dogru, U Ozcelik, N Kiper
WHAT IS KNOWN AND OBJECTIVE: Antibiotic therapy aimed at eradicating Pseudomonas aeruginosa (Pa), and improved regimens to treat chronic Pa infection have played a major role in increasing the median survival of patients with cystic fibrosis (CF). However, different clinical centres use varying eradication regimens. The aim of this study was to evaluate the efficacy of multiple eradication treatments against initial Pa infection and to determine the factors affecting the treatment success...
August 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27284755/inhaled-corticosteroid-related-adrenal-suppression-detected-by-poor-growth-and-reversed-with-ciclesonide
#13
Brian S Liddell, John M Oberlin, Daniel P Hsu
INTRODUCTION: This case series intends to highlight the association between decreased linear growth velocity and adrenal suppression in patients receiving inhaled corticosteroids for asthma. A potential treatment option is also discussed. Adrenal suppression secondary to inhaled corticosteroids has previously been reported and is often under recognized. A decrease in linear height velocity has also been associated with inhaled corticosteroids. However a decrease in height velocity has not been shown to predict adrenal suppression...
June 10, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27257988/an-18-year-old-man-with-recurrent-pneumothorax-since-he-was-10-year-old
#14
Meral Demir, Nazan Çobanoğlu
An 18-year-old male patient was referred to the department of pediatric pulmonology with a history of recurrent pneumothorax. Initial pneumothorax occurred at the age of 10. Following diagnosis of congenital lobar emphysema, he had five episodes of pneumothorax and subsequently underwent right-lower lobe anterobasal segmentectomy. Based on thoracic computed tomography (CT) and clinical manifestation, Birt-Hogg-Dube (BHD) syndrome was suspected and confirmed following genetic testing. BHD syndrome is a rare tumor predisposition syndrome first described in 1977...
December 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27238183/standards-for-diagnosis-and-care-of-patients-with-inherited-alpha-1-antitrypsin-deficiency-recommendations-of-the-polish-respiratory-society-polish-society-of-pediatric-pulmonology-and-polish-society-of-pediatric-gastroenterology
#15
Joanna Chorostowska-Wynimko, Agnieszka Bakuła, Marek Kulus, Paweł Kuca, Ewa Niżankowska-Mogilnicka, Marek Sanak, Piotr Socha, Paweł Śliwiński
No abstract text is available yet for this article.
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/27171478/pediatric-pulmonology-year-in-review-2015-part-4
#16
REVIEW
Adrienne P Savant, Susanna A McColley
In this article, we highlight cystic fibrosis (CF) research published in Pediatric Pulmonology during 2015. Articles from other journals that reflect similar themes, and those of special importance, are also included. Pediatr Pulmonol. 2016;51:754-765. © 2016 Wiley Periodicals, Inc.
July 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27148701/pediatric-pulmonology-year-in-review-2015-part-2
#17
REVIEW
Jean-Paul Praud
Pediatric Pulmonology covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review (Part 2) covers articles on sleep-disordered breathing. Pediatr Pulmonol. 2016;51:740-746. © 2016 Wiley Periodicals, Inc...
July 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27124279/pediatric-pulmonology-year-in-review-2015-part-1
#18
REVIEW
Richard Auten, Jurgen Schwarze, Clement Ren, Stephanie Davis, Terry L Noah
Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection. Pediatr Pulmonol. 2016;51:733-739...
July 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27105321/pediatric-pulmonology-year-in-review-2015-part-3
#19
REVIEW
David J Birnkrant, Ozge Yilmaz, Thomas Nicolai, Jane B Black, Maroun J Mhanna, Terry L Noah
Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review (Part 3) covers articles on asthma, diagnostic testing/endoscopy, respiratory complications of neuromuscular disorders, and rare lung diseases...
July 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27093355/pediatric-pulmonology-with-thin-phenotyping-and-deep-genotyping-knowledge-is-power
#20
David N Cornfield
No abstract text is available yet for this article.
June 2016: Current Opinion in Pediatrics
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