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https://www.readbyqxmd.com/read/27890785/genomic-characterization-of-dysplastic-nevi-unveils-implications-for-diagnosis-of-melanoma
#1
Rachel D Melamed, Iraz T Aydin, Geena Susan Rajan, Robert Phelps, David N Silvers, Kevin J Emmett, Georg Brunner, Raul Rabadan, Julide Tok Celebi
A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes that are in a senescent-like state, but with occasional malignant transformation events. To portray the mutational repertoire of dysplastic nevi in patients with the dysplastic nevus syndrome, and to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), followed by a targeted gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42)...
November 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27847790/synchronous-primary-anorectal-melanoma-and-sigmoid-adenocarcinoma
#2
Inju Cho, Kyung Jong Kim, Sung-Chul Lim
A primary anorectal malignant melanoma is a rare tumor. Moreover, cases involving a synchronous anorectal melanoma and colon adenocarcinoma are extremely rare. The authors report a case of a synchronous anorectal melanoma and sigmoid adenocarcinoma in an 84-year-old man. The regions of the anorectal melanoma showed melanocytic nevi in the adjacent mucosa of the anal canal and rectum. A dysplastic nevus was also identified in the anal mucosa. This case demonstrates that an anorectal melanoma can arise from pre-existing anorectal melanocytic lesions...
October 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/27824229/agminated-congenital-hairy-dysplastic-nevus
#3
Betul Tas, Funda A Saydam, Idris Ersin, Aysel Cağlar
No abstract text is available yet for this article.
December 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27648381/solitary-mastocytoma-presenting-in-an-adult-report-and-literature-review-of-adult-onset-solitary-cutaneous-mastocytoma-with-recommendations-for-evaluation-and-treatment
#4
REVIEW
Philip R Cohen
BACKGROUND: Mastocytosis is either cutaneous (with skin-limited proliferation of mast cells) or systemic (with mast cells in extracutaneous sites). The onset of solitary mastocytoma in an adult is rare. PURPOSE: A woman with the new onset of solitary mastocytoma is described. The clinical features of patients with adult-onset solitary mastocytoma are summarized. Recommendations for the evaluation and treatment of individuals with adult-onset solitary mastocytoma are proposed...
July 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27617734/agminated-melanocytic-nevus-status-post-dabrafenib-therapy-for-metastatic-melanoma
#5
Alfredo Agulló, Brian Hinds, Raquel Santesteban, Josune Mitxelena Mitxelena, Ignacio Yanguas
Agminated melanocytic nevus is an uncommon type of mole, characterized by a local group of macular or papular pigmented lesions, well demarcated, without a common pigmented background. This pattern has also been associated with Spitz nevi, dysplastic melanocytic nevi, and non-melanocytic lesions.We describe the onset of an acquired agminated melanocytic nevus after dabrafenib treatment. Our case highlights paradoxical MAPK activation in the setting of single-agent BRAF blockade and underscores the importance of characterizing the diverse side effects of selective BRAF inhibitors...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27551173/dermatological-findings-in-turkish-paediatric-haematology-oncology-patients
#6
Umit Uksal, Pinar Ozturk, Emine Colgecen, Nazan Taslidere, Turkan Patiroglu, Mehmet Akif Ozdemir, Yasemin Altuner Torun, Murat Borlu
OBJECTIVE: Diagnoses of skin, mucosae, hair and nail manifestations in malignant diseases are often challenging because of life-threatening drug reactions, opportunistic infections or skin involvement of primary processes. Description of morphology, configuration and distribution of lesions is important in order to differentiate the self-healing eruptions from serious side effects of chemotherapy. There are case reports from Turkey including dermatological manifestations of malignancies and case series in adult patients but there are no published large group studies assessing all manifestations in children...
June 2016: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/27542070/reexamining-the-threshold-for-reexcision-of-histologically-transected-dysplastic-nevi
#7
Nathaniel H Fleming, Barbara M Egbert, Jinah Kim, Susan M Swetter
Importance: Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN). Objective: To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised with negative margins. Design, Setting, and Participants: Retrospective cohort study of mixed referral and community patients from an academic pigmented lesion clinic and dermatology clinics of the affiliated Veteran Affairs medical center with biopsy-confirmed DN with positive histologic margins diagnosed from May 15, 1991, to July 8, 2015, and followed up through May 30, 2016...
August 17, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27465047/-melanoma-questions-and-answers-development-and-evaluation-of-a-psycho-educational-resource-for-people-with-a-history-of-melanoma
#8
Nadine A Kasparian, Shab Mireskandari, Phyllis N Butow, Mbathio Dieng, Anne E Cust, Bettina Meiser, Kristine Barlow-Stewart, Scott Menzies, Graham J Mann
PURPOSE: People with melanoma often report pervasive fears about cancer recurrence, unmet information needs, and difficulties accessing psychological care. Interventions addressing the supportive care needs of people with melanoma are rare, and needs are often overlooked. The study evaluated a newly developed, evidence-based, psycho-educational resource for people with melanoma. METHODS: The evaluation study comprised three groups: adults at high risk of new primary disease due to multiple previous melanomas or one melanoma and dysplastic nevus syndrome (DNS), adults at moderate risk due to one previous melanoma and no DNS, and health professionals involved in melanoma care...
July 27, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27444088/erythematous-violaceous-macule-on-the-chest-in-a-patient-with-dysplastic-nevus-syndrome
#9
Nancy Rivas-Tolosa, Onofre Sanmartín, Víctor Traves, Carlos Guillén, Eduardo Nagore
No abstract text is available yet for this article.
August 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27178687/cutaneous-manifestations-of-genitourinary-malignancy
#10
REVIEW
Derek Raghavan
Genitourinary cancers are associated with a range of cutaneous syndromes, which can reflect direct metastatic spread, non-metastatic manifestations of malignancy or the consequences of treatment. More than 220,000 new cases of prostate cancer occur each year in the United States, and thus the associations with cutaneous involvement are quite well documented-rare metastatic spread, vasculitic and hemorrhagic syndromes. Cancers of the bladder and kidney may be associated with direct cutaneous metastases, vasculitic syndromes, hereditary leiomyomatosis, and other familial syndromes...
June 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27149137/meyerson-phenomenon-as-a-component-of-melanoma-in-situ
#11
Engin Sezer, Emel Özturk Durmaz, Emel Çetin, Sedef Şahin
Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a banal melanocytic nevus. Herein, we describe an unusual case with MP representing an eczematized response to a melanoma in situ and review the literature covering this entity. A 56-year-old man presented with a 6-month history of a pruritic, pigmented lesion on the trunk. The patient had no other significant medical history and no notable family history of similar lesions...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27149135/knowledge-about-ultraviolet-radiation-hazards-and-tanning-behavior-of-cosmetology-and-medical-students
#12
Ewelina Bogumiła Zuba, Wojciech Francuzik, Przemysław Malicki, Agnieszka Osmola-Mańkowska, Dorota Jenerowicz
Dear Editor, Ultraviolet (UV) radiation is a well-known physical hazard responsible for photoaging, photoallergic, and phototoxic reactions as well as carcinogenesis, including life-threatening melanomas (1,2). Overexposure to both natural and artificial UV radiation is a public health concern. 30% of cancers diagnosed worldwide are skin cancers. Approximately three million non-melanoma skin cancers and 132 000 new cases of melanomas are diagnosed globally each year (3). Sunburns, especially in childhood, are a very important risk factor for melanomas...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27001787/nevus-flammeus-associated-with-dysplastic-nevi-and-lichen-sclerosus-the-first-report-in-the-medical-literature
#13
G Maximov, A Chokoeva, S Philipov, J Cardoso, G Ivanov, U Wollina, G Tchernev
We describe a rare case of a 28 year-old male patient presenting with pruritus and increased sensitivity of the prepuce accompanied by erythematous confluent papules, unilateral nevus flammeus (NF) along almost the whole length of the right lower limb and two dysplastic nevi (DN), one located on the mid back and the other on the medial border of the right fifth toe, the latter coinciding with the NF. A biopsy of the prepuce revealed lichen sclerosus et atrophicus (LSA). Mental health assessment revealed anxiety disorder and predisposition to panic attacks...
February 2016: Georgian Medical News
https://www.readbyqxmd.com/read/26914472/large-acquired-nevus-or-dysplastic-nevus-what-s-in-the-name-of-a-nevus
#14
Rainer Hofmann-Wellenhof, Ashfaq A Marghoob, Iris Zalaudek
No abstract text is available yet for this article.
June 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/26719659/dysplastic-nevus-with-eruptive-melanocytic-lesions-that-developed-during-nilotinib-therapy-for-chronic-myeloid-leukemia
#15
Joo Hyun Lee, Jin Hee Kang, Baik Kee Cho, Hyun Jeong Park
No abstract text is available yet for this article.
December 2015: Annals of Dermatology
https://www.readbyqxmd.com/read/26713207/fiber-bundle-microendoscopy-with-sub-diffuse-reflectance-spectroscopy-and-intensity-mapping-for-multimodal-optical-biopsy-of-stratified-epithelium
#16
Gage J Greening, Haley M James, Amy J Powless, Joshua A Hutcheson, Mary K Dierks, Narasimhan Rajaram, Timothy J Muldoon
Early detection of structural or functional changes in dysplastic epithelia may be crucial for improving long-term patient care. Recent work has explored myriad non-invasive or minimally invasive "optical biopsy" techniques for diagnosing early dysplasia, such as high-resolution microendoscopy, a method to resolve sub-cellular features of apical epithelia, as well as broadband sub-diffuse reflectance spectroscopy, a method that evaluates bulk health of a small volume of tissue. We present a multimodal fiber-based microendoscopy technique that combines high-resolution microendoscopy, broadband (450-750 nm) sub-diffuse reflectance spectroscopy (sDRS) at two discrete source-detector separations (374 and 730 μm), and sub-diffuse reflectance intensity mapping (sDRIM) using a 635 nm laser...
December 1, 2015: Biomedical Optics Express
https://www.readbyqxmd.com/read/26645459/update-on-thin-melanoma-outcome-of-an-international-workshop
#17
Daniela Mihic-Probst, Chris Shea, Lyn Duncan, Arnaud de la Fouchardiere, Gilles Landman, Jennifer Landsberg, Joost ven den Oord, Lori Lowe, Martin G Cook, Sook Jung Yun, Loren Clarke, Jane Messina, David E Elder, Raymond L Barnhill
The following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated nevi, inflamed and regressing nevi, and dysplastic nevi. Histologic criteria for this analysis were discussed and the importance of clinico-pathologic correlation, especially in acral sites, was emphasized...
January 2016: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/26476911/atypical-spitz-tumor-of-uncertain-biologic-potential-with-inopportune-localization-in-a-7-year-old-boy
#18
LETTER
Nedeljka Glavan, Gordana Zamolo, Miljenko Katunarić, Nives Jonjić
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/26430487/impact-of-guidance-provided-by-a-multispectral-digital-skin-lesion-analysis-device-following-dermoscopy-on-decisions-to-biopsy-atypical-melanocytic-lesions
#19
Richard R Winkelmann, Jane Yoo, Natalie Tucker, Richard White, Darrell S Rigel
OBJECTIVE: To determine how a multispectral digital skin lesion analysis (MSDSLA) device data affects the biopsy performance of dermatologists and non-dermatologist practitioners following clinical and dermoscopic pigmented lesion evaluation. DESIGN: MSDSLA employs near infrared light to image and analyze pigmented skin lesions. MSDSLA generates a "classifier score" based on morphological disorganization. Using a logistical regression model, 1) a probability of being melanoma and, 2) a probability of being melanoma, atypical melanocytic hyperplasia, or a high grade dysplastic nevus is computed...
September 2015: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/26297393/oral-melanocytic-nevi-a-clinicopathologic-study-of-100-cases
#20
Leticia Ferreira, Bruno Jham, Rouba Assi, Allison Readinger, Harvey P Kessler
OBJECTIVE: The purpose of this study was to evaluate the clinical and histopathologic features of oral melanocytic nevi (OMN). STUDY DESIGN: One hundred cases of OMN were retrieved from the files of two oral pathology services, and the data were analyzed with regard to histologic type and clinical features. RESULTS: Intramucosal nevus was the most common type (61%), followed by common blue nevus (23%), compound nevus (7%), and junctional nevus (3%)...
September 2015: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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