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Beta 2 microglobulin

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https://www.readbyqxmd.com/read/29221492/elevated-serum-%C3%AE-2-microglobulin-in-individuals-coinfected-with-hepatitis-b-and-hepatitis-d-virus-in-a-rural-settings-in-southwest-nigeria
#1
Lawrence Ehis Okoror, Ayodele Oluwaseun Ajayi, Oluwaseun Benjamin Ijalana
OBJECTIVE: Coinfection of hepatitis B virus (HBV) with hepatitis D virus (HDV) has being reported to increase severity of progression to hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Beta microglobulin (2βM) which is present on the surfaces of blood cells in acceptable levels is a tumor marker which may become elevated in disease conditions. This study hence observed the prevalence of HBV and HDV coinfection in a rural population and their 2βM concentration. RESULTS: Of the 368 samples, 66 (17...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29214761/clinicopathological-characteristics-of-hyperdiploidy-with-high-risk-cytogenetics-in-multiple-myeloma
#2
Naery Yang, Yeung Chul Mun, Chu Myong Seong, Hee Jin Huh, Jungwon Huh
In multiple myeloma (MM), hyperdiploidy (HD) is known to impart longer overall survival. However, it is unclear whether coexistent HD ameliorates the adverse effects of known high-risk cytogenetics in MM patients. To address this issue, we investigated the clinicopathological characteristics of HD with high-risk cytogenetics in MM. Ninety-seven patients with MM were included in the study. For metaphase cytogenetics (MC), unstimulated cells from bone marrow aspirates were cultured for either 24 or 48 hours. To detect HD by interphase fluorescence in situ hybridization (iFISH), we assessed trisomies of chromosomes 5, 7, 9, 11, 15, and 17...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29206983/cytogenetic-profiling-of-myelomas-association-with-complete-blood-count-study-of-180-patients
#3
Anil Tarigopula, Vani Chandrashekar, Perumal Govindasamy
Objectives: To analyze the most common primary and secondary cytogenetic events in myelomas using a probe panel designed in our laboratory, and to associate those events with hematological and biochemical findings. Methods: Blood specimens from patients diagnosed with myeloma were processed to determine complete blood count and levels of albumin, creatinine, and beta-2 microglobulin. We evaluated bone-marrow specimens for plasma-cell percentage by light microscopy and for cytogenetic abnormalities by fluorescence in situ hybridization (FISH)...
December 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29186592/beta-2-microglobulin-clearance-in-high-flux-dialysis-and-convective-dialysis-modalities-a-meta-analysis-of-published-studies
#4
Maria-Eleni Roumelioti, Gregory Trietley, Thomas D Nolin, Yue-Harn Ng, Zhi Xu, Ahmed Alaini, Rocio Figueroa, Mark L Unruh, Christos P Argyropoulos
Background: Recent meta-analyses suggest that higher removal of beta-2 microglobulin (β2M) with either high-flux (HFD) dialysis or hemodiafiltration (HDF) may be associated with decreased total and cardiovascular mortality in dialysis patients. However, there are limited data about the performance of high flux dialyzers and/or convective therapies in removing β2M. Methods: This is a random effects meta-analysis and meta-regression of data extracted from randomized controlled trials and observational studies in hemodialysis, hemofiltration and HDF regarding the efficiency of high flux dialyzers to remove β2M...
November 27, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29161752/prenatal-megacystis-is-prediction-of-outcome-and-renal%C3%A2-function-possible
#5
Regina Tschannen, Rita Gobet, Josef Wisser
Objective To assess prenatal prognostic criteria for fetuses with megacystis in order to counsel parents. Methods In a retrospective observational study at a single tertiary referral center, we assessed the clinical course of 53 fetuses with megacystis cared for at the Department of Obstetrics of the University Hospital Zurich between 1995 and 2008 and followed them up for 2 to 12 years. We determined fetal karyotype, amniotic fluid volume and fetal urinary biochemistry as prenatal prognostic factors...
November 21, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29119483/low-level-laser-therapy-for-xerostomia-in-primary-sj%C3%A3-gren-s-syndrome-a-randomized-trial
#6
Tania Fidelix, Adriano Czapkowski, Sergio Azjen, Adagmar Andriolo, Pedro Horvath Neto, Virgínia Trevisani
To evaluate the effectiveness of low-level laser therapy (LLLT) in the treatment of xerostomia in primary Sjögren's syndrome (SS), a randomized clinical trial of patients with dry mouth symptoms associated with primary SS receiving care at a university hospital was conducted. Sixty-six patients were randomly assigned with a 1:1 allocation ratio to receive LLLT (laser group, n = 33) or placebo treatment (placebo group, n = 33). Patients in the laser group received LLLT twice a week for 6 weeks, for a total of 12 treatment sessions...
November 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29110585/cell-free-dna-levels-and-correlation-to-stage-and-outcome-following-treatment-of-locally-advanced-rectal-cancer
#7
Anders Kindberg Boysen, Yvonne Wettergren, Boe Sandahl Sorensen, Helena Taflin, Bengt Gustavson, Karen-Lise Garm Spindler
Accurate staging of rectal cancer remains essential for optimal patient selection for combined modality treatment, including radiotherapy, chemotherapy and surgery. We aimed at examining the correlation of cell free DNA with the pathologic stage and subsequent risk of recurrence for patients with locally advanced rectal cancer undergoing preoperative chemoradiation. We examined 75 patients with locally advanced rectal cancer receiving preoperative chemoradiation. Blood samples for translational use were drawn prior to rectal surgery...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29108452/comparative-study-of-radioprotective-effects-of-selenium-nanoparticles-and-sodium-selenite-in-irradiation-induced-nephropathy-of-mice-model
#8
Masoumeh Karami, Siamak Asri-Rezaie, Banafshe Dormanesh, Ali Nazarizadeh
PURPOSE: The current study was undertaken to evaluate radioprotective effects of selenium nanoparticles in irradiation induced nephropathy of mice model compared to sodium selenite. MATERIALS AND METHODS: Forty-five mice were divided into 3 major groups including control, selenium nanoparticle and sodium selenite. Each major group was further subdivided into 3 more groups receiving various doses of 0, 2 and 8 Gy gamma irradiation. Both of the supplements were administered intraperitoneally with the dose of 0...
November 7, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29070816/resistance-to-checkpoint-blockade-therapy-through-inactivation-of-antigen-presentation
#9
Moshe Sade-Feldman, Yunxin J Jiao, Jonathan H Chen, Michael S Rooney, Michal Barzily-Rokni, Jean-Pierre Eliane, Stacey L Bjorgaard, Marc R Hammond, Hans Vitzthum, Shauna M Blackmon, Dennie T Frederick, Mehlika Hazar-Rethinam, Brandon A Nadres, Emily E Van Seventer, Sachet A Shukla, Keren Yizhak, John P Ray, Daniel Rosebrock, Dimitri Livitz, Viktor Adalsteinsson, Gad Getz, Lyn M Duncan, Bo Li, Ryan B Corcoran, Donald P Lawrence, Anat Stemmer-Rachamimov, Genevieve M Boland, Dan A Landau, Keith T Flaherty, Ryan J Sullivan, Nir Hacohen
Treatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance to these agents remain incompletely characterized and have yet to be validated in large cohorts. By analyzing longitudinal tumor biopsies from 17 metastatic melanoma patients treated with CPB therapies, we observed point mutations, deletions or loss of heterozygosity (LOH) in beta-2-microglobulin (B2M), an essential component of MHC class I antigen presentation, in 29...
October 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/29051524/the-international-staging-system-improves-the-ipi-risk-stratification-in-patients-with-diffuse-large-b-cell-lymphoma-treated-with-r-chop
#10
Xiaolei Wei, Xiaoxiao Hao, Lizhi Zhou, Qi Wei, Yuankun Zhang, Weimin Huang, Jialin Song, Ru Feng, Yongqiang Wei
The international staging system (ISS), based on serum beta-2 microglobulin and albumin, is used to predict survival in multiple myeloma, but its prognostic significance in diffuse large B-cell lymphoma (DLBCL) remains unknown. Herein, we retrospectively analyzed 215 de novo DLBCL patients. According to ISS, there were 90 of 215 (41.9%) patients in stage I, 98 of 215 (45.6%) in stage II and 27 of 215 (12.6%) in stage III group. Patients with ISS stage II/III showed shorter overall survival (OS) and event free survival (EFS) than those with stage I treated with R-CHOP (p = 0...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29016645/spontaneous-variability-of-pre-dialysis-concentrations-of-uremic-toxins-over-time-in-stable-hemodialysis-patients
#11
Sunny Eloot, Wim Van Biesen, Sanne Roels, Willem Delrue, Eva Schepers, Annemieke Dhondt, Raymond Vanholder, Griet Glorieux
BACKGROUND AND AIM: Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points. The reliability of these studies however entirely depends on how representative these cross-sectional concentrations are. We therefore investigated the variability of predialysis concentrations of uremic toxins over time. METHODS: Prospectively collected predialysis serum samples of the midweek session of week 0, 1, 2, 3, 4, 8, 12, and 16 were analyzed for a panel of uremic toxins in stable chronic HD patients (N = 18) while maintaining dialyzer type and dialysis mode during the study period...
2017: PloS One
https://www.readbyqxmd.com/read/28992939/kidney-function-bone-mineral-metabolism-markers-and-future-risk-of-peripheral-artery-disease
#12
Chao Yang, Lucia Kwak, Shoshana H Ballew, Pranav S Garimella, Bernard G Jaar, Aaron R Folsom, Gerardo Heiss, Elizabeth Selvin, Pamela L Lutsey, Josef Coresh, Kunihiro Matsushita
BACKGROUND AND AIMS: Reduced kidney function is a risk factor for lower-extremity peripheral artery disease (PAD). However, the associations of novel filtration markers with PAD are yet to be quantified. Moreover, little is known on whether bone-mineral metabolism (BMM) markers are related to incident PAD beyond kidney function. METHODS: Using data from 12,472 participants at baseline (1990-1992) of the Atherosclerosis Risk in Communities (ARIC) study, we comprehensively quantified the associations of kidney related markers with incident PAD (defined as hospitalizations with diagnosis of lower-extremity atherosclerosis, revascularization, or amputation)...
September 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28987956/determination-of-stable-reference-genes-for-rt-qpcr-expression-data-in-mechanistic-pain-studies-on-pig-dorsal-root-ganglia-and-spinal-cord
#13
Dale A Sandercock, Jennifer E Coe, Pierpaolo Di Giminiani, Sandra A Edwards
RNA expression levels for genes of interest must be normalised with appropriate reference or "housekeeping" genes that are stably expressed across samples and treatments. This study determined the most stable reference genes from a panel of 6 porcine candidate genes: beta actin (ACTB), beta-2-microglobulin (B2M), eukaryotic elongation factor 1 gamma-like protein (eEF-1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), succinate dehydrogenase complex subunit A (SDHA), Ubiquitin C (UBC) in sacral dorsal root ganglia and spinal cord samples collected from 16 tail docked pigs (2/3rds of tail amputated) 1, 4, 8 and 16weeks after tail injury (4 pigs/time point)...
October 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28980060/phase-i-study-of-a-chloroquine-gemcitabine-combination-in-patients-with-metastatic-or-unresectable-pancreatic-cancer
#14
Panagiotis Samaras, Marina Tusup, Thi Dan Linh Nguyen-Kim, Burkhardt Seifert, Helga Bachmann, Roger von Moos, Alexander Knuth, Steve Pascolo
PURPOSE: Following a previously published pre-clinical validation, this phase I study evaluated the safety, maximum tolerated dose, anti-tumour activity and immune status of a gemcitabine-chloroquine combination as a first- or late-line treatment in patients with metastatic or unresectable pancreatic cancer. METHODS: In this 3 + 3 dose escalation study, patients received a single weekly standard dose of intravenous gemcitabine, followed by single weekly oral intake of 100, 200 or 300 mg of chloroquine...
October 4, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28979155/role-of-serum-cystatin-c-and-beta-2-microglobulin-as-early-markers-of-renal-dysfunction-in-children-with-beta-thalassemia-major
#15
Ola Galal Behairy, Eman Rateb Abd Almonaem, Neveen Tawfik Abed, Omima M Abdel Haiea, Rasha M Zakaria, Rania I AbdEllaty, Effat H Asr, Amira Ibrahim Mansour, Amira Mn Abdelrahman, Hoda A Elhady
BACKGROUND: Although advancements have been made in the management of thalassemic patients, many unrecognized complications have emerged, such as renal abnormalities. AIM: To measure serum levels of cystatin-C and β-2 microglobulin in children with beta-thalassemia major (β-TM) and investigate their significance as early markers of glomerular and tubular dysfunctions. SUBJECTS AND METHODS: The study was performed on 70 children with (β-TM) and 20 apparently healthy children matched for age and sex as a control group...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28962515/corrigendum-to-serum-beta-2-microglobulin-levels-for-predicting-acute-kidney-injury-complicating-aortic-valve-replacement-interact-cardiovasc-thorac-surg-25-2017-533-540-doi-10-1093-icvts-ivx198
#16
Marta Zaleska-Kociecka, Anna Skrobisz, Izabela Wojtkowska, Maciej Grabowski, Maciej Dabrowski, Krzysztof Kusmierski, Katarzyna Piotrowska, Jacek Imiela, Janina Stepinska
No abstract text is available yet for this article.
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28962501/serum-beta-2-microglobulin-levels-for-predicting-acute-kidney-injury-complicating-aortic-valve-replacement
#17
Marta Zaleska-Kociecka, Anna Skrobisz, Izabela Wojtkowska, Maciej Grabowski, Maciej Dabrowski, Krzysztof Kusmierski, Katarzyna Piotrowska, Jacek Imiela, Janina Stepinska
OBJECTIVES: Acute kidney injury complicating both transcatheter and surgical aortic valve replacement is associated with high rates of morbidity and mortality. The aim of this study was to investigate the role of serum beta 2 (β2) microglobulin, cystatin C and neutrophil gelatinase-associated lipocalin levels in detecting periprocedural acute kidney injury. METHODS: Eighty consecutive patients who were 70 years of age or older and who were having surgical (n = 40) or transcatheter (n = 40) aortic valve replacement were recruited in a prospective study...
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28936029/silicon-nanoporous-membranes-as-a-rigorous-platform-for-validation-of-biomolecular-transport-models
#18
Benjamin J Feinberg, Jeff C Hsiao, Jaehyun Park, Andrew L Zydney, William H Fissell, Shuvo Roy
Microelectromechanical systems (MEMS), a technology that resulted from significant innovation in semiconductor fabrication, have recently been applied to the development of silicon nanopore membranes (SNM). In contrast to membranes fabricated from polymeric materials, SNM exhibit slit-shaped pores, monodisperse pore size, constant surface porosity, zero pore overlap, and sub-micron thickness. This development in membrane fabrication is applied herein for the validation of the XDLVO (extended Derjaguin, Landau, Verwey, and Overbeek) theory of membrane transport within the context of hemofiltration...
August 15, 2017: Journal of Membrane Science
https://www.readbyqxmd.com/read/28910787/middle-molecule-uremic-toxins-and-outcomes-in-chronic-kidney-disease
#19
Ziad A Massy, Sophie Liabeuf
In patients with chronic kidney disease (CKD), uremic toxins constitute a specific nontraditional risk factor. Research in this field started in the early 1990s, and a growing body of preclinical and epidemiological evidence suggests that elevated levels of uremic toxins are associated with poor outcomes in a CKD setting. The present review focuses on a specific class of uremic toxins (the "middle molecules"), which includes well-known candidates like beta-2 microglobulin and fibroblast growth factor 23. Here, we summarize the epidemiological evidence linking the middle-molecule uremic toxin (and especially the larger ones) with hard clinical end points...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28882602/neurosurgical-aspects-of-dialysis-related-spinal-amyloidosis-report-of-three-cases-and-a-review-of-the-literature
#20
M Dalolio, F Lucarella, P Rampini, G P Bulfamante, S Aldea, P Graveleau, S Gaillard, P Scarone
BACKGROUND AND PURPOSE: Osteoarticular manifestations of beta-2 microglobulin amyloidosis are often diagnosed in long-term dialyzed patients. However, spinal involvement is rare (10-25% of patients), and generally not associated with neurological deterioration. Compression of the spinal cord or roots is extremely rare, and probably under-recognized. METHODS: The authors describe three cases of spinal stenosis presenting with neurological signs in long-term dialyzed patients, prospectively collected over 2 years in two different institutions and treated by surgical decompression...
September 4, 2017: Neuro-Chirurgie
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