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Beta 2 microglobulin

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https://www.readbyqxmd.com/read/29602711/tenofovir-disoproxil-fumarate-co-administered-with-lopinavir-ritonavir-is-strongly-associated-with-tubular-damage-and-chronic-kidney-disease
#1
Daisuke Mizushima, Dung Thi Hoai Nguyen, Dung Thi Nguyen, Shoko Matsumoto, Junko Tanuma, Hiroyuki Gatanaga, Nguyen Vu Trung, Nguyen van Kinh, Shinichi Oka
BACKGROUD: With expanding antiretroviral therapy (ART) in a resource-limited setting, the use of second line ART with ritonavir boosted lopinavir (LPV/r) is increasing. However, little is known regarding the renal safety of tenofovir (TDF) co-administered with LPV/r. METHODS: In total 1382 HIV-infected patients were enrolled and data were recorded twice (October 2014 and 2015) in Vietnam. Tubular dysfunction (TD) was defined as urinary beta 2 microglobulin (β2MG) > 1000 μg/L at both timepoints or increase in β2MG by > 2000 μg/L...
March 27, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29575245/long-term-renal-tubular-damage-in-intrauterine-growth-restricted-rats
#2
Yayoi Murano, Hiromichi Shoji, Taichi Hara, Ikeda Naho, Amane Endo, Naoto Nishizaki, Toshiaki Shimizu
BACKGROUND: Several investigations have shown an association between intrauterine growth restriction (IUGR) and increased risk for renal diseases or hypertension in the later stages of life. However, mainly glomerular dysfunction is reported and limited information is available to link IUGR with renal tubular damage. The aim of this study was to investigate urinary markers of tubular damage in a rat model of IUGR induced by bilateral uterine artery ligation. METHODS: Pregnant Sprague-Dawley rats underwent bilateral uterine artery ligation, and sham surgeries were performed for the control group...
March 25, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29573958/beta-2-microglobulin-and-the-severity-of-coronary-stenosis-in-patients-with-acute-coronary-syndrome
#3
Chenglong Zhang, Fengjuan Li, Tianyi Long, Fei Li, Liming Peng, Ke Xia, Ran Jing, Qiying Xie, Tianlun Yang
BACKGROUND: Previous studies have shown that beta 2-microglobulin (B2M) could predict all-cause mortality and cardiovascular mortality in various groups of people. However, the relationship between B2M and severity of coronary stenosis in patients with acute coronary syndrome has not been established. METHODS: We enrolled 872 consecutive patients admitted with acute coronary syndrome in our study. All participants underwent coronary angiography examination or stent implantation after admission...
March 5, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29571109/yucca-schidigera-extract-modulates-the-lead-induced-oxidative-damage-nephropathy-and-altered-inflammatory-response-and-glucose-homeostasis-in-japanese-quails
#4
Mayada R Farag, Mahmoud Alagawany, Mohamed E Abd El-Hack, Sabry A A El-Sayed, Sarah Y A Ahmed, Dalia H Samak
The present study was conducted to explore the toxic effects of lead (Pb) on the physiological responses of Japanese quails and to investigate the potential modulatory role of Yucca schidigera extract (YSE) against these effects. 360 mature Japanese quails (at 2 months of age) were used and the experiment was lasted for 8 weeks. The birds were divided into six equal groups as follow: control (basal diet, BD), BD+Pb (100 mg/kg diet), BD+YSE (100 mg/kg diet), BD+YSE (200 mg/kg diet), BD+Pb (100 mg/kg diet) +YSE (100 mg/kg diet) and BD+ Pb (100 mg/kg diet) + YSE (200 mg/kg diet)...
March 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29552435/plasmacytoma-of-the-skull-base-a-rare-tumor
#5
Abhilasha Siyag, Tej P Soni, Anil K Gupta, Lalit M Sharma, Naresh Jakhotia, Shantanu Sharma
Plasmacytoma of the skull-base is a rare entity. Differential diagnosis includes chordoma, osteosarcoma, carcinoma nasopharynx, meningioma, metastatic carcinoma, lymphoma, and multiple myeloma. Accurate and precise diagnosis is extremely important for plasmacytoma of the skull-base as its treatment and prognosis is different from other skull-base lesions. A 41-year-old man presented with concerns of headache, diplopia, and left eye strabismus. A magnetic resonance image (MRI) of his brain showed a large expansile mass measuring 51 mm involving the clivus and central skull-base...
January 15, 2018: Curēus
https://www.readbyqxmd.com/read/29549883/severe-abdominal-pain-and-diarrhea-unusual-multiple-myeloma-presentation-with-a-severe-prognosis-a-case-report
#6
Douglas A Salguero, Pamela A Barletta, Willaim Sierraalta
BACKGROUND: Multiple myeloma is a hematologic disease with high mortality rates all over the world. The diagnosis has always been challenging since the first case was reported in 1844. For that reason the diagnostic criteria have evolved over years to include the features of the disease more comprehensively. Unusual presentations are infrequent and a diagnostic challenge. For this reason we report this rare case in which diarrhea and abdominal pain were the initial presenting symptoms of multiple myeloma with a plasmacytoma...
March 18, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29513304/a-prognostic-score-for-survival-in-patients-older-than-65-years-with-diffuse-large-b-cell-lymphoma
#7
Myrna Candelaria, Nancy Reynoso-Noverón, Mayra Ponce, Rodrigo Castillo-Llanos, Diana Nolasco-Medina, David Cantú-De-Leon
Background: Available prognosis scores for patients with diffuse large B-cell lymphoma (DLBCL) included a limited number of patients ≥ 65 years of age, and most of them did not include comorbidities. Here, we propose a prognostic score for overall survival (OS) for this group of patients. Materials and Methods: Patients ≥ 65 years with DLBCL treated at a single national reference center were included. Clinical features including comorbidities and biochemical parameters were analyzed...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29499887/assessment-of-kidney-function-in-patients-with-cancer
#8
REVIEW
Verônica Torres da Costa E Silva, Elerson C Costalonga, Fernanda O Coelho, Renato A Caires, Emmanuel A Burdmann
Cancer patients are living longer. The sequelae of cancer treatment and the role of comorbid conditions present before the diagnosis, such as CKD, have been increasingly recognized. The interface between CKD and cancer is multifaceted. CKD is frequently observed in patients with cancer, and cancer treatment contributes to CKD development and progression. In addition, CKD has been recognized as an important risk factor for cancer development and reduced specific cancer survival. In this context, an accurate evaluation of the glomerular filtration rate (GFR) during oncologic treatment is pivotal and is used to define surgery strategies, program prophylactic management of contrasted examinations, make decisions on cisplatin eligibility, and adjust drug prescriptions, particularly chemotherapy agents...
January 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29486722/study-protocol-rationale-and-design-of-the-community-based-prospective-cohort-study-of-kidney-function-and-diabetes-in-rural-new-mexico-the-compass-study
#9
Antonin Jaros, Hafiz A Sroya, Venita K Wolfe, Vikas Ghai, Maria-Eleni Roumelioti, Kamran Shaffi, Kai Wang, Vernon Shane Pankratz, Mark L Unruh, Christos Argyropoulos
BACKGROUND: Rural areas in the state of New Mexico have been the "ground-zero" for the epidemic of diabetic Chronic Kidney Disease (CKD) in the United States. However, there is limited research about risk factors of diabetic CKD in this area and scarce data regarding the performance of emerging markers of renal filtration and epigenetic biomarkers of renal function and diabetes in this area with its unique ethnic/racial population. We designed the COMPASS study as a community-based program in rural New Mexico aiming to screen for CKD and to discover CKD-related translational biomarkers...
February 27, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29465367/proprotein-convertase-enzyme-furin-is-upregulated-in-primary-sj%C3%A3-gren-s-syndrome
#10
Noora Ranta, Atte Valli, Anna Grönholm, Olli Silvennoinen, Pia Isomäki, Marko Pesu, Marja Pertovaara
OBJECTIVES: The proprotein convertase enzyme FURIN is a critical regulator of the anti-inflammatory TGFβ-1 cytokine and peripheral immune tolerance. In T cells, FURIN is co-regulated with IFN-γ and thus highly expressed in T helper 1 type cells. Previous studies have demonstrated that FURIN is upregulated in inflammatory conditions, including atherosclerosis, rheumatoid arthritis and systemic lupus erythematosus. Here, we evaluated the levels of FURIN in the plasma and peripheral blood mononuclear cells (PBMCs) of patients with primary Sjögren's syndrome (pSS) and in healthy controls...
February 21, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29461232/nephropathy-in-early-rheumatoid-arthritis-patients-does-a-significant-risk-exist
#11
D Rekalov, A Prytkova, R Kulynych, G Protsenko, V Protsenko
Objective of the study layed in assessment of the pathophysiological relation between cell-mediated immunity (tumor necrosis factor-alpha (TNF-α) inflammatory cytokine) activation and renal dysfunction in the patients with early rheumatoid arthritis. We analyzed the data from 35 early rheumatoid arthritis (RA) patients of average age of 50,71±2,25 years (ranged 18-76 years, 80% of women) with 9,21±0,43 months mean duration of the disease by the time of the study initiation. Urine and blood tests were performed to verify the main indicators of kidney function and inflammation cytokines significant interaction...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29451067/combined-detection-of-umcp-1-and-utweak-for-rapid-discrimination-of-severe-lupus-nephritis
#12
X W Dong, Z H Zheng, J Ding, X Luo, Z Q Li, Y Li, M Y Rong, Y L Fu, J H Shi, L C Yu, Z B Wu, P Zhu
Reliable markers for the rapid discrimination of severe renal damage remain a vital concern for lupus nephritis (LN). To determine a better tool for kidney damage detection, the present study compared the evaluation ability of novel urinary cytokines and chemokines (namely urinary monocyte chemoattractant protein 1 (uMCP-1), tumor necrosis factor-like weak inducer of apoptosis (uTWEAK)) with traditional serum or urinary markers (namely urinary alpha 1-microgrobulin (uα1-MG), beta 2-microglobulin (uβ2-MG) and serum complement C3 (C3), complement C4 (C4), creatinine (Cr), blood urea nitrogen (BUN) and cystatin C (Cys C)) in discriminating LN renal damage...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29427355/rituximab-cladribine-and-cyclophosphamide-rcc-induction-with-rituximab-maintenance-in-chronic-lymphocytic-leukemia-palg-cll4-ml21283-trial
#13
Tadeusz Robak, Jerzy Blonski, Aleksander Bartłomiej Skotnicki, Magdalena Piotrowska, Tomasz Wróbel, Justyna Rybka, Janusz Kłoczko, Łukasz Bołkun, Bożena Katarzyna Budziszewska, Urszula Walczak, Anatoly Uss, Marta Fidecka, Piotr Smolewski
OBJECTIVES: PALG CLL4 is the first, randomized, phase IIIb study with cladribine, cyclophosphamide and rituximab (RCC) induction and subsequent maintenance with rituximab in previously untreated chronic lymphocytic leukemia (CLL) patients. METHODS: The induction treatment consisted of six RCC cycles regimen. Patients with complete response (CR) or partial response (PR) after an induction phase were randomized into a maintenance arm with rituximab or an observational arm...
February 10, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29425954/slit-pores-preferred-over-cylindrical-pores-for-high-selectivity-in-biomolecular-filtration
#14
Benjamin J Feinberg, Jeff C Hsiao, Jaehyun Park, Andrew L Zydney, William H Fissell, Shuvo Roy
Microelectromechanical systems (MEMS) have enabled the fabrication of silicon nanopore membranes (SNM) with uniform non-overlapping "slit shaped" pores. The application of SNM has been suggested for high selectivity of biomolecules in a variety of medical filtration applications. The aim of this study was to rigorously quantify the differences in sieving between slit pore SNM and more commonly modeled cylindrical pore membranes, including effects of the extended Derjaguin, Landau, Verwey, and Overbeek (XDLVO) interactions...
December 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29417568/n-terminal-b-type-natriuretic-peptide-nt-probnp-is-associated-with-disease-severity-in-multiple-myeloma
#15
Noemi Pavo, Anna Cho, Raphael Wurm, Guido Strunk, Maria Krauth, Hermine Agis, Martin Hülsmann
BACKGROUND: Elevated levels of cardiovascular markers including N-terminal B-type natriuretic peptide (NT-proBNP) have been shown to be associated with disease severity and mortality in an unselected population of cancer patients without cardiac disease. The aim of the present study was to investigate whether NT-proBNP levels are related to disease severity in multiple myeloma (MM) and to assess the natural course of NT-proBNP levels throughout disease progression. MATERIALS AND METHODS: We retrospectively analyzed a total of 118 patients with MM, who were followed-up routinely...
February 8, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29403496/recent-advances-in-targeting-cd8-t-cell-immunity-for-more-effective-cancer-immunotherapy
#16
REVIEW
Aurélie Durgeau, Yasemin Virk, Stéphanie Corgnac, Fathia Mami-Chouaib
Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and programmed cell death (PD)-1. In this context, anti-CTLA-4 and anti-PD-1 monoclonal antibodies have demonstrated survival benefits in numerous cancers, including melanoma and non-small-cell lung carcinoma. PD-1-expressing CD8+ T lymphocytes appear to play a major role in the response to these immune checkpoint inhibitors (ICI). Cytotoxic T lymphocytes (CTL) eliminate malignant cells through recognition by the T-cell receptor (TCR) of specific antigenic peptides presented on the surface of cancer cells by major histocompatibility complex class I/beta-2-microglobulin complexes, and through killing of target cells, mainly by releasing the content of secretory lysosomes containing perforin and granzyme B...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29392554/cystatin-c-is-a-gender-neutral-glomerular-filtration-rate-biomarker-in-patients-with-cirrhosis
#17
Ayse L Mindikoglu, Antone R Opekun, William E Mitch, Laurence S Magder, Robert H Christenson, Thomas C Dowling, Matthew R Weir, Stephen L Seliger, Charles D Howell, Jean-Pierre Raufman, Abbas Rana, John A Goss, Saira A Khaderi, John M Vierling
BACKGROUND: Lower serum Cr levels in women as compared to men result in underestimation of renal dysfunction and lower model for end-stage liver disease-sodium scores leading to reduced access to liver transplantation in women compared to men with comparable hepatic dysfunction. AIM: The aim of this study was to determine the gender differences in serum Cr, cystatin C, and other endogenous glomerular filtration rate (GFR) biomarkers, measured and estimated GFR, Cr clearance, and Cr production rates...
February 1, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29388463/endogenous-markers-for-kidney-function-in-children-a-review
#18
Emil den Bakker, Reinoud J B J Gemke, Arend Bökenkamp
Although glomerular filtration rate (GFR) in children can be measured using a gold-standard technique following injection of an exogenous marker, this invasive and cumbersome technique is not widely available and GFR is commonly estimated using serum levels of endogenous markers. Creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin are well-established endogenous markers of kidney function. These markers differ in site of production and effects of diet and medication, as well as renal-tubular handling and extra-renal elimination...
February 1, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29377394/platelet-predominate-gene-expression-and-reticulated-platelets-in-non-valvular-atrial-fibrillation-effect-of-pulmonary-veins-isolation
#19
Waldemar E Wysokinski, Alfonso Tafur, Yanhong Wu, Naser Ammash, Samuel J Asirvatham, Izabela Gosk-Bierska, Diane E Grill, Joshua P Slusser, Jozef Mruk, Robert D McBane
INTRODUCTION: Reticulated platelet (RP) content is increased in non-valvular atrial fibrillation (NVAF). The purpose of this study was to determine if platelet content, morphology and RP proportion are modulated by platelet genes. METHODS AND RESULTS: Expression of 6 platelet-predominate genes impacting platelet formation and release, platelet count and RP content were assessed in NVAF patients before and 3-4 months after pulmonary veins isolation (PVI) and compared to normal sinus rhythm (NSR) controls...
January 29, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29373876/prognostic-value-of-il-10-and-its-relationship-with-disease-stage-in-iranian-patients-with-multiple-myeloma
#20
Ramin Shekarriz, Ghasem Janbabaei, Saeed Abedian Kenari
Background: Several studies have demonstrated roles of interleukins in the pathogenesis of multiple myeloma (MM). Objective: Here we considered correlations among serum levels of IL-10, stage of disease and clinical laboratory disease markers in Iranian MM patients to investigate whether the interleukin might have prognostic significance. Materials and Methods: In this cross-sectional study, a total of 60 subjects (40 patients and 20 controls) were recruited. After preliminary laboratory tests, disease stage was evaluated and serum levels of IL-10 were measured using an enzymelinked immunosorbent assay (ELISA)...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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