keyword
https://read.qxmd.com/read/38527598/exposure-to-the-antineoplastic-ifosfamide-alters-molecular-pathways-related-to-cardiovascular-function-increases-heart-rate-and-induces-hyperactivity-in-zebrafish-danio-rerio
#21
JOURNAL ARTICLE
Cole D English, Kira J Kazi, Isaac Konig, Emma Ivantsova, Christopher L Souders Ii, Christopher J Martyniuk
Ifosfamide is an alkylating antineoplastic drug used in chemotherapy, but it is also detected in wastewater. Here, the objectives were to (1) determine teratogenic, cardiotoxic, and mitochondrial toxicity potential of ifosfamide exposure; (2) elucidate mechanisms of toxicity; (3) characterize exposure effects on larval behavior. Survival rate, hatch rate, and morphological deformity incidence were not different amongst treatments following exposure levels up to 1000µg/L ifosfamide over 7 days. RNA-seq reveled 231 and 93 differentially expressed transcripts in larvae exposed to 1µg/L and 100µg/L ifosfamide respectively...
March 23, 2024: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/38526584/pharmacological-articles-in-the-german-magazine-die-zeit-the-time-content-adequacy-and-comprehensibility
#22
JOURNAL ARTICLE
Laura Sophie Böger, Roland Seifert
The German weekly magazine DIE ZEIT (THE TIME) reaches more than one million readers per issue, mainly from high-income social classes. Pharmacological content is frequent in DIE ZEIT. As it therefore reaches many people who generally have no in-depth knowledge of pharmacology, it can be assumed that DIE ZEIT is an important primary source of information. It should be its task to depict the drugs widely used by the population and to present them correctly and comprehensibly. This study analyzes 71 articles from 2012 to 2022 in terms of form, content, and comprehensibility...
March 25, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38526363/-a-case-of-right-heart-failure-when-it-is-not-pulmonary-embolism
#23
JOURNAL ARTICLE
Enrico Tadiello, Emma Zimelli, Giulia Urbani, Tommaso Hinna Danesi, Daniela Reghellin, Claudio Bilato
A 66-year-old patient with recent instrumental findings (echocardiogram, cardiac magnetic resonance imaging) of right ventricular failure was hospitalized due to worsening signs and symptoms of right heart failure, while waiting for diagnostic definition. Pulmonary computed tomography angiography revealed findings compatible with bilateral pulmonary thromboembolism involving the main pulmonary artery. Anticoagulant therapy was initiated with initial benefit, partial relief of symptoms, and moderate improvement in right ventricular function...
April 2024: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/38526360/-multidistrict-atherosclerotic-disease-epidemiological-and-clinical-framework
#24
JOURNAL ARTICLE
Stefania Angela Di Fusco, Maurizio Giuseppe Abrignani, Antonio Francesco Amico, Fabiana Lucà, Gian Francesco Mureddu, Roberto Ceravolo, Pier Luigi Temporelli, Vincenzo Acerbo, Vito Altamura, Danilo Baccino, Giulio Binaghi, Giulia Bugani, Arturo Cesaro, Francesco Ciccirillo, Sara Cocozza, Paola D'Errigo, Mirko Di Martino, Concetta Di Nora, Luca Fileti, Vincenzo Lopriore, Alessandro Maloberti, Francesco Monitillo, Michele Massimo Gulizia, Massimo Grimaldi, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi
Atherosclerosis is a systemic disease that can involve different arterial districts. Traditionally, the focus of cardiologists has been on the diagnosis and treatment of atherosclerotic coronary artery disease (CAD). However, atherosclerosis localization in other districts is increasingly common and is associated with an increased risk of CAD and, more generally, of adverse cardiovascular events. Although the term peripheral arterial disease (PAD) commonly refers to the localization of atherosclerotic disease in the arterial districts of the lower limbs, in this document, in accordance with the European Society of Cardiology guidelines, the term PAD will be used for all the locations of atherosclerotic disease excluding coronary and aortic ones...
April 2024: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/38525771/exploring-brain-and-heart-interactions-during-electroconvulsive-therapy-with-point-of-care-ultrasound
#25
JOURNAL ARTICLE
Marvin G Chang, Tracy A Barbour, Edward A Bittner
BACKGROUND: Electroconvulsive therapy (ECT) is a procedure commonly used to treat a number of severe psychiatric disorders, including pharmacologic refractory depression, mania, and catatonia by purposefully inducing a generalized seizure that results in significant hemodynamic changes as a result of an initial transient parasympathetic response that is followed by a marked sympathetic response from a surge in catecholamine release. While the physiologic response of ECT on classic hemodynamic parameters such as heart rate and blood pressure has been described in the literature, real-time visualization of cardiac function using point-of-care ultrasound (POCUS) during ECT has never been reported...
March 22, 2024: Medical Sciences: Open Access Journal
https://read.qxmd.com/read/38523810/editorial-asics-structure-function-and-pharmacology-part-ii
#26
EDITORIAL
Enrique Soto, Candice Askwith
No abstract text is available yet for this article.
2024: Frontiers in Physiology
https://read.qxmd.com/read/38523030/advancing-immunosuppression-in-liver-transplantation-a-narrative-review
#27
REVIEW
Samuele Iesari, Francesca Laura Nava, Ilaria Elena Zais, Laurent Coubeau, Mariano Ferraresso, Evaldo Favi, Jan Lerut
Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation (LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, de novo cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solid-organ transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT...
March 16, 2024: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38522762/blockade-of-endothelial-adenosine-receptor-2a-suppresses-atherosclerosis-in-vivo-through-inhibiting-creb-alk5-mediated-endothelial-to-mesenchymal-transition
#28
JOURNAL ARTICLE
Yongfeng Cai, Yaqi Zhou, Qiuhua Yang, Jiean Xu, Qingen Da, Qian Ma, Dingwei Zhao, Tammy Lu, Ha Won Kim, David Fulton, Xuejun Jiang, Neal L Weintraub, Kunzhe Dong, Suowen Xu, Mei Hong, Zhiping Liu, Yuqing Huo
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and morbidity and mortality rates continue to rise. Atherosclerosis constitutes the principal etiology of CVDs. Endothelial injury, inflammation, and dysfunction are the initiating factors of atherosclerosis. Recently, we reported that endothelial adenosine receptor 2A (ADORA2A), a G protein-coupled receptor (GPCR), plays critical roles in neovascularization disease and cerebrovascular disease. However, the precise role of endothelial ADORA2A in atherosclerosis is still not fully understood...
March 22, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38522637/functional-mitral-regurgitation-and-heart-failure-with-preserved-ejection-fraction-clinical-implications-and-management
#29
REVIEW
M Riccardi, M Cikes, M Adamo, M Pagnesi, C M Lombardi, S D Solomon, M Metra, R M Inciardi
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and associated with worse cardiovascular outcomes. The pathophysiology of HFpEF mostly relies on the development of elevated left ventricle filling pressure, diastolic dysfunction, atrial dilatation and impairment. This dynamic process may eventually lead to the development of functional mitral regurgitation, characterized by mitral annular dilatation and consequent leaflet remodelling, in the context of preserved left ventricular ejection fraction...
March 22, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38522319/recent-advances-in-the-therapeutic-potential-of-nobiletin-against-respiratory-diseases
#30
REVIEW
Yanqin Qin, Jingfan Yang, Haibo Li, Jiansheng Li
BACKGROUND: Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been demonstrated to exert the effects of anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic and improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role in respiratory diseases (RDs) treatment. OBJECTIVE: This review aimed to investigate the therapeutic potential of nobiletin against RDs, such as lung cancer, COPD, pulmonary fibrosis, asthma, pulmonary infection, acute lung injury, coronavirus disease 2019, and pulmonary arterial hypertension...
March 1, 2024: Phytomedicine
https://read.qxmd.com/read/38518995/human-recombinant-relaxin-2-serelaxin-regulates-the-proteome-lipidome-lipid-metabolism-and-inflammatory-profile-of-rat-visceral-adipose-tissue
#31
JOURNAL ARTICLE
Alana Aragón-Herrera, Sandra Feijóo-Bandín, Xocas Vázquez-Abuín, Laura Anido-Varela, Sandra Moraña-Fernández, Susana B Bravo, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Javier García-Seara, José Seijas, Diego Rodríguez-Penas, Daniele Bani, Oreste Gualillo, José Ramón González-Juanatey, Francisca Lago
Recombinant human relaxin-2 (serelaxin) has been widely proven as a novel drug with myriad effects at different cardiovascular levels, which support its potential therapeutic efficacy in several cardiovascular diseases (CVD). Considering these effects, together with the influence of relaxin-2 on adipocyte physiology and adipokine secretion, and the connection between visceral adipose tissue (VAT) dysfunction and the development of CVD, we could hypothesize that relaxin-2 may regulate VAT metabolism. Our objective was to evaluate the impact of a 2-week serelaxin treatment on the proteome and lipidome of VAT from Sprague-Dawley rats...
March 20, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38518887/how-to-assess-non-responsiveness-to-vasodilator-stress
#32
JOURNAL ARTICLE
Phillip Lim, Vikram Agarwal, Krishna K Patel
Myocardial perfusion imaging (MPI) is a powerful tool for the functional assessment of ischemia in patients with suspected or known coronary artery disease (CAD). Given that the diagnostic accuracy and prognostic value of MPI and post-test management are highly dependent on achieving an adequate stress vasodilatory response, it is critical to identify those who may not have adequately responded to vasodilator pharmacological stress agents such as adenosine, dipyridamole, and regadenoson. Caffeine, a potent inhibitor of the adenosine receptor, is a compound that can affect vasodilatory hemodynamics, result in false negative studies, and potentially alter management in cases of inaccurate test results...
March 20, 2024: Journal of Nuclear Cardiology
https://read.qxmd.com/read/38517253/ultra-early-hemostatic-therapy-for-acute-intracerebral-hemorrhage-an-updated-review
#33
JOURNAL ARTICLE
Michael Fortunato, Galadu Subah, Anish D Thomas, Bridget Nolan, Monica Mureb, Anaz Uddin, Kiran Upadhyay, Jonathan V Ogulnick, Nitesh Damodara, Colleen Bond, Chirag D Gandhi, Stephan A Mayer, Fawaz Al-Mufti
Intracerebral hemorrhage (ICH) is the second most common type of stroke, accounting for approximately 10-20% of all strokes, and is linked to severe neurological disability and death. Since the most accurate predictor of outcome in patients with ICH is hematoma volume, there is a great need for pharmacologic therapy that can reduce hematoma expansion and resultant mass effect and edema. This is especially critical within the ultra-early window of 3-4 hours after the presentation. Hemostatic therapies are exceptionally important for those patients taking antiplatelet or anticoagulant medications to reverse the effects of these medications and therefore prevent hematoma expansion...
March 21, 2024: Cardiology in Review
https://read.qxmd.com/read/38517229/a-cell-atlas-of-thoracic-aortic-perivascular-adipose-tissue-a-focus-on-mechanotransducers
#34
JOURNAL ARTICLE
Janice M Thompson, Stephanie W Watts, Leah Terrian, G Andres Contreras, Cheryl Rockwell, C Javier Rendon, Emma Wabel, Lizbeth Lockwood, Sudin Bhattacharya, Rance Nault
Perivascular adipose tissue (PVAT) is increasingly recognized for its function in mechanotransduction. However, major gaps remain in our understanding of the cells present in PVAT, as well as how different cells contribute to mechanotransduction. We hypothesized that snRNA seq would reveal expression of mechanotransducers, and test one (PIEZO1) to illustrate the expression and functional agreement between single-nuclei RNA sequencing (snRNAseq) and physiological measurements. To contrast two brown tissues, subscapular brown adipose tissue (BAT) was also examined...
March 22, 2024: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38517201/review-article-upper-gastrointestinal-bleeding-review-of-current-evidence-and-implications-for-management
#35
REVIEW
Dennis L Shung, Loren Laine
BACKGROUND: Acute upper gastrointestinal bleeding (UGIB) is a common emergency requiring hospital-based care. Advances in care across pre-endoscopic, endoscopic and post-endoscopic phases have led to improvements in clinical outcomes. AIMS: To provide a detailed, evidence-based update on major aspects of care across pre-endoscopic, endoscopic and post-endoscopic phases. METHODS: We performed a structured bibliographic database search for each topic...
March 22, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38516524/growing-concerns-about-using-hypoxia-inducible-factor-prolyl-hydroxylase-inhibitors-for-the-treatment-of-renal-anemia
#36
REVIEW
Takeshi Nakanishi, Takahiro Kuragano
Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have emerged as a novel therapeutic class for treating anemia in patients with chronic kidney disease. Small molecule analogs of α-ketoglutarate (AKG), an essential substrate for 2-oxoglutarate-dependent dioxygenases (2-OGDDs), including prolyl hydroxylase domain proteins (PHDs), inhibit PHDs pharmacologically and thereby prevent HIF degradation. HIF stabilization alleviates anemia through several stimulatory effects on erythropoiesis, but it also affects the expression of many anemia-unrelated genes whose protein products exert important functions in vivo ...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38515856/article-review-brazilin-as-potential-anticancer-agent
#37
REVIEW
Callista Najla Raptania, Syifa Zakia, Alistia Ilmiah Fahira, Riezki Amalia
Brazilin is the main compound in Caesalpinia sappan and Haematoxylum braziletto , which is identified as a homoisoflavonoid based on its molecular structure. These plants are traditionally used as an anti-inflammatory to treat fever, hemorrhage, rheumatism, skin problems, diabetes, and cardiovascular diseases. Recently, brazilin has increased its interest in cancer studies. Several findings have shown that brazilin has cytotoxic effects on colorectal cancer, breast cancer, lung cancer, multiple myeloma, osteosarcoma, cervical cancer, bladder carcinoma, also other cancers, along with numerous facts about its possible mechanisms that will be discussed...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38515851/validity-and-reliability-of-the-romanian-version-of-the-hill-bone-compliance-to-high-blood-pressure-therapy-scale
#38
JOURNAL ARTICLE
Răzvan-Nicolae Rusu, Radu Sebastian Gavril, Daniela Carmen Ababei, Ioana Macadan, Andrei Ciobîcă, Camelia Nicolae, Răducu Ionuț Popescu, Walther Bild, Veronica Bild
Romania is considered a country with high cardiovascular risk, arterial hypertension and its complications accounting for about 60% of total deaths. The management of high blood pressure often involves a combination of both therapeutic regimens as well as lifestyle changes, to which patients have to be adherent. In order to assess patients adherence to professionals' recommendations, validated tools are needed. The aim of our study was to translate, culturally adapt and validate the Hill-Bone Compliance to High Blood Pressure Therapy Scale into Romanian...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38513826/perivascular-fat-tissue-and-vascular-aging-a-sword-and-a-shield
#39
REVIEW
Yan Wang, Xianmin Wang, Yang Chen, Yuelin Zhang, Xianjie Zhen, Siyu Tao, Jinfang Dou, Peng Li, Guangjian Jiang
The understanding of the function of perivascular adipose tissue (PVAT) in vascular aging has significantly changed due to the increasing amount of information regarding its biology. Adipose tissue surrounding blood vessels is increasingly recognized as a key regulator of vascular disorders. It has significant endocrine and paracrine effects on the vasculature and is mediated by the production of a variety of bioactive chemicals. It also participates in a number of pathological regulatory processes, including oxidative stress, immunological inflammation, lipid metabolism, vasoconstriction, and dilation...
March 19, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38513341/synthetic-approaches-and-clinical-application-of-small-molecule-inhibitors-of-sodium-dependent-glucose-transporters-2-for-the-treatment-of-type-2-diabetes-mellitus
#40
REVIEW
Tong Xie, Li-Jie Zhao
Sodium-dependent glucose transporters 2 (SGLT2) inhibitors are a class of small-molecule drugs that have gained significant attention in recent years for their potential clinical applications in the treatment of type 2 diabetes mellitus (T2DM). These inhibitors function by obstructing the kidneys' ability to reabsorb glucose, resulting in a rise in the excretion of glucose in urine (UGE) and subsequently lowering blood glucose levels. Several SGLT2 inhibitors, such as Dapagliflozin, Canagliflozin, and Empagliflozin, have been approved by regulatory authorities and are currently available for clinical use...
March 18, 2024: European Journal of Medicinal Chemistry
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